• Eddy, Allison

    Investigator, BC Children's Hospital
    Head, Department of Pediatrics, University of British Columbia

    Professor, Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University of British Columbia

    Degrees / Designations
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Lab Phone
    Mailing Address
    BC Children's Hospital
    Room 2D15
    4500 Oak Street

    Vancouver, BC V6H 3N1

    Affiliate Websites
    Research Areas
    • Kidney fibrosis
    • Extracellular matrix
    • Macrophages
    • Myofibroblasts
    • Mannose receptors

    Chronic kidney disease (CKD) is a significant and growing public health problem. It is currently estimated that 13% of the adult population has CKD and it confers a 5-fold increased risk of premature cardiovascular disease and death. Those who survive long enough eventually require renal replacement therapy with dialysis or a kidney transplant. Many of the risk factors for CKD begin in childhood. a patient develops CKD, the pathological changes that worsen dysfunction are similar in all kidney diseases, and are characterized by a process of ongoing scarring or fibrosis. Despite tremendous progress in our understanding of the causes and consequences of CKD, effective therapies are unknown. Using experimental models of CKD, our studies are designed to investigate how specific cells and molecules mediate kidney fibrosis, with the ultimate goal of translating our findings into new human therapies.

    Current Projects
    Selected Publications

    López-Guisa JM, Cai X, Collins SJ, Yamaguchi I, Okamura DM, Bugge TH, Isacke CM, Emson CL, Turner SM, Shankland SJ, Eddy AA. Mannose receptor 2 attenuate renal fibrosis. JASN 23:236-51, 2012. Cover photograph. PMID: 22095946

    Yamaguchi I, Tchao BN, Burger ML, Yamada M, Hyodo T, Giampietro C and Eddy AA. Vascular endothelial cadherin modulates renal interstitial fibrosis. Nephron Exp Nephrol 25;120:e20-e31, 2011. PMID: 22126970

    Eddy AA, Okamura DM, Yamaguchi I, López-Guisa JM. Investigating mechanisms of chronic kidney disease in mouse models. Pediatr Nephrol 2011 June 22 [Epub ahead of print]. PMID: 21695449

    Eddy AA. Scarping fibrosis. UMODulating renal fibrosis. Nature Medicine 17:553-555, 2011. PMID: 21546974

    Lopez-Guisa JM, Rassa AC, Cai X, Collins SJ, Eddy AA. Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease. Am J Physiol Renal Physiol 300:F1244-F1254, 2011. PMID: 21270094

    Okamura DM, Pasichnyk K, Lopez-Guisa JM, Collins S., Hsu DK, Liu F-T, Eddy AA. Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis. Am J Physiol Renal Physiol 300:F245-253, 2011. PMID: 20962111

    Zhang G, Kernan KA, Thomas A, Collins S, Song Y, Li L, LeBoeuf R, and Eddy AA. Fibroblast nicotinic receptor α binds urokinase and promotes renal fibrosis. J Biol Chem, 284:29050-64, 2009. PMID: 19690163

    Okamura DM, Pennathur S, Koelsch K, Lopez-Guisa JM, Collins SJ, Febbraio M, Heinecke J, Eddy AA. CD36 is regulates oxidative stress and inflammation in hypercholesterolemic chronic kidney disease. J Am Soc Nephrol 20:495-505, 2009. PMID: 19211715

    Ricardo S, van Goor H, Eddy AA. Macrophage diversity in renal injury and repair. J Clin Invest 118:3522-30, 2008. PMID: 18982158

    Zhang G, Collins SJ, Cai X, López-Guisa JM, Degen JL, Shvil Y, Eddy AA: Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: Role of plasmin-activated signals. J Am Soc Nephrol 18:846-859, 2007. Cover photograph. PMID: 17267741


    Basic science:
    P50 DK044757 (Fogo PI). NIH/NIDDK, "Fibrotic Sequelae of Childhood Renal Disease" George M. O'Brien Pediatric Kidney Research Center, $86,000 current year. (2007–2012: renewal under review). Dr. Eddy is the PI for project #4: "Role of renal tubular scavenger proteins in progressive kidney disease".

    N/A (Okamura PI, Eddy Co-PI). Cystinosis Research Foundation, "Elucidating the Role of Cystinosin-Deficient Macrophages in Nephropathic Cystinosis", $218,966/2 years. (2011-2013). The goal of this project is to investigate the hypothesis that cystinosin deficiency leads to macrophage dysfunction that contributes to the pathogenesis of chronic kidney disease.

    Casey Lee Ball Foundation (Eddy PI). "Identification of small molecules that enhance Mrc2-dependent collagen degradation as a novel therapy for chronic kidney disease", $55,177.(2011-2012). The primary goal of this proposal is screen a large panel of small molecules for their ability to induce expression on the Mrc2 collagen receptor.

    R01 DK54500 (Eddy PI). NIH/NIDDK, "Molecular Mechanisms in Renal Interstitial Fibrosis", $235,000. (1999-2010). The major goal of this project is to elucidate the role of protease inhibitors in renal interstitial fibrosis.

    N/A (Eddy PI). Cystinosis Research Foundation, "Cysteamine Effects on Extracellular Matrix Accumulation in Chronic Kidney Disease", $242,916/3 years. (2008-2011). The goal of this project is to investigate the anti-fibrotic effects of therapeutic cysteamine in mouse chronic kidney disease models.

    Training Career Development:
    T32 DK07662 (Eddy PI). NIH/NRSA, Pediatric Nephrology Training Program, $274,895 current year. (2006-2016). The goal is to train academic pediatric nephrologists.

    K12 HD043376 (Stapleton PI). NIH/NICHD, Cellular and Molecular Biology of Development, $400,000 current year. (2003-2012). The goal is support career development of junior investigators who have recently completed Pediatric subspecialty training. Dr. Eddy was the Program Director until 03/16/2012.

    Clinical Research:
    Pilot and Feasibility Grant (Eddy PI). Washington Global Health Alliance, Impact of Kidney Dysfunction on Mortality Rates in Ugandan Children Hospitalized with Acute Infections. $75,000. (2007-2010). The goal of this project is to establish a mechanism to evaluate renal function for children admitted to Mulago hospital with pneumonia, malaria and gastroenteritis and to determine the impact of renal failure on acute mortality rates.

    Honours & Awards

    First recipient of The Robert O. Hickman Endowed Chair in Pediatric Nephrology, University of Washington (2007-2012).

    Deputy Editor JASN 2001-2007; Associate Editor Pediatric Nephrology (2009-present).

    Elected to the Council of the International Society of Pediatric Nephrology (1995-2001) and the International Society of Nephrology (2009-2015).

    Scientific Program Committee Co-chair for triannual congresses on the International Society of Pediatric Nephrology in 1989, 2011 and 2013.

    Research Group Members