• Beasley, Clare

    Titles

    Investigator, BC Children's Hospital
    Associate Professor, Department of Psychiatry, Faculty of Medicine, University of British Columbia

    Degrees / Designations
    Primary Area of Research
    Brain, Behaviour & Development
    Secondary Area(s) of Research
    Phone
    604 875-2000 ext. 4723
    Fax
    Lab Phone
    Mailing Address

    BC Children's Hospital
    4480 Oak Street
    Room A3-115
    Vancouver, BC V6H 3N1

    Affiliate Websites
    Research Areas
    • Neuropathology of schizophrenia, bipolar disorder and major depressive disorder
    • White matter
    • Inflammation
    • Antipsychotic Drugs
    • Neurodevelopment
    • Proteomics
    • Histology
    Summary

    The major aim of my research is to identify changes in the brains of individuals with schizophrenia, bipolar disorder and major depressive disorder that may elucidate the etiology of these disorders and provide clues to novel treatments. Current projects focus on white matter pathology and inflammation. In addition, we study the effects of antipsychotic medications on the brain.

    Current Projects
    Selected Publications

    Andreazza AC, Barakauskas VE, Fazeli S, Feresten A, Shao L, Wei V, Wu CH, Barr AM, Beasley CL. Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum. Neurosci Lett. 2015 591:36-40. PMID: 25684243

    Hercher C, Chopra V, Beasley CL. Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder. J Psychiatry Neurosci. 2014 39(6):376-385. PMID: 24936776

    Feresten AH, Barakauskas V, Ypsilanti A, Barr AM, Beasley CL. Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness. Schizophr Res. 2013 150(1):252-257. PMID: 23911257

    Epp JR, Beasley CL, Galea LA. Increased hippocampal neurogenesis and p21 expression in depression: dependent on antidepressants, sex, age, and antipsychotic exposure. Neuropsychopharmacology. 2013 38(11):2297-2306. PMID: 23778854

    Barr AM, Wu CH, Wong C, Hercher C, Töpfer E, Boyda HN, Procyshyn RM, Honer WG, Beasley CL. Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats. Neuroscience. 2013 255:147-157. PMID: 24141179

    Vila-Rodriguez, F., Honer, W. G., Innis, S. M., Wellington, C. L., & Beasley, C. L. (2011). ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype. Journal of Psychiatry & Neuroscience : JPN, 36(1), 47-55. PMID: 20964956 

    Barakauskas, V. E., Ypsilanti, A. R., Barr, A. M., Innis, S. M., Honer, W. G., & Beasley, C. L. (2010). Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(4), 669-673. PMID: 20227455

    Barakauskas, V. E., Beasley, C. L., Barr, A. M., Ypsilanti, A. R., Li, H. Y., Thornton, A. E., Wong, H., Rosokija, G., Mann, J.J., Mancevski, B., Jakovski, Z., Davceva, N., Illevski, B., Dwork, A.J., Falkai, P., & Honer, W. G. (2010). A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. 
    Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 35(5), 1226-1238. PMID: 20072114

    Beasley, C. L., Honavar, M., Everall, I. P. & Cotter, D. (2009). Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder. 
    Schizophr Res., 115(2-3), 156-62. PMID: 19833481

    Beasley, C. L., Dwork, A. J., Rosoklija, G., Mann, J.J., Mancevski, B., Jakovski, Z., Davceva, N., Tait, A.R., Straus, S.K., & Honer, W.G. (2009). Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia.
    Schizophr Res., 109(1-3), 159-66. PMID: 19272755

    Pennington, K., Beasley, C. L., Dicker, P., Fagan, A., English, J., Pariante, C.M., Wait, R., Dunn, M.J., & Cotter, D.R. (2008). Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. 
    Mol Psychiatry., 13(12), 1102-17. PMID: 17938637

    Foster, R., Kandanearatchi, A., Beasley, C., Williams, B., Khan, N., Fagerhol, M.K., & Everall, I.P. (2006). Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: evidence for an inflammatory process?
     Eur J Neurosci., 24(12), 3561- 6. PMID: 17229104

    Beasley, C. L., Pennington, K., Behan, A., Wait, R., Dunn, M. J. & Cotter, D. (2006). Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes. 
    Proteomics, 6(11), 3414-25. PMID: 16637010

    Grants
    Honours & Awards
    Research Group Members