• Sandor, George

    Titles

    Investigator, BC Children's Hospital
    Professor Emeritus, Division of Cardiology, Department of Pediatrics, University of British Columbia

    Degrees / Designations
    MBchB, FRCPC
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2954
    Fax
    604-875-3463
    Lab Phone
    Assistant
    Leslie Gault
    Assistant Phone
    604-875-2295
    Mailing Address

    BC Children's Hospital
    Room 1F27
    4480 Oak Street
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Congenital heart disease
    • Echocardiography
    • Cardiac and vascular function
    Summary

    My area of research is congenital heart disease. The focus is a) the use of echocardiography to assess cardiac and vascular function with and without exercise and also b) fetal echocardiography.

    Current Projects

    Structure and function of the heart can be examined using ultrasound. My interest lies in using the latest ultrasound to characterize the heart’s ability to pump and to fill. This work attempts to accurately assess and diagnose abnormalities of function early, and to compare the results of different types of medical and surgical treatment to evaluate outcome. Our laboratory has been a pioneer in the simplification of non-invasive methods of assessing heart function and we have also developed a new technique to quantify the properties of the major blood vessels coming from the heart to see whether these are diseased or healthy. We are also examining the interaction of heart function with the properties of the blood vessels to see how efficient the heart and circulation are. These types of studies are of importance in patients who have some compromise of cardiac function, so that therapy may be optimised to enable the heart to work most efficiently.

    Our laboratory has devised a technique whereby the heart can be imaged with ultrasound during exercise and with this technique are able to obtain indexes of cardiac function, cardiac output and examine the heart muscle contractility using stage exercise. This technique is unique and has been extremely useful in assessing the cardiac reserve in patients for whom decisions have to be made with regard to surgery, continuing potentially cardiotoxic medications and assessing the effects of these. This has been found very helpful in situations where the examination of the heart at rest has not provided enough information about the potential heart to do exercise. In addition, this technique has been very helpful in unmasking a partial blockage in blood vessels whereby exercise increased the cardiac output and has demonstrated a significant degree of obstruction that is not apparent in the resting state. We have undertaken some of this work for the Adult Congenital Heart Disease Program.

    The antenatal diagnosis of congenital heart disease continues to develop and we have been one of the first centers to institute a fetal cardiac diagnosis program. This is unique in that it integrates perinatology and the fetal diagnosis program, which help in the management of these difficult situations. In addition to evaluating the accuracy of this technique, we have also examined issues of outcomes, population statistics and just as importantly, a qualitative study of such diagnoses. We have also started to use an adaptation of the technique of assessment of the vascular properties by ultrasound (alluded to in the previous paragraphs) to attempt to assess fetal circulatory health, and we hope that this test will give us further insights into placental insufficiency and perhaps an earlier diagnosis of such problems.

    Selected Publications

    Jackson CM, Sandor GGS, Lim K, Duncan WJ, Potts JE. Diagnosis of fetal ductus aneurysm, importance of the 3-vessel view. Ultrasound in Obstetrics and Gynecology (in press).
     
    Bradley TJ, Potts JE, de Souza A, Sandor GGS. Echo Doppler assessment of aortic stiffness and impedance in pediatric patients with Marfan syndrome. American Journal of Cardiology (in press).
     
    Dahlgren L, Lim K, Tessier F, Skoll A, Farquharson DF, Duncan WD, Sandor GGS. Is the Nuchal Index Increased in Fetuses with Congenital Structural Heart Defects. Fetal Diagnosis and Therapy (in press).
     
    Walmsley R, Hishitani T, Sandor GG, Lim K, Duncan W, Tessier F, Farquharson DF, Potts JE. Diagnosis and outcome of dextrocardia diagnosed in the fetus. AM J Cardiol. 2004 1;94(1):141-3.
     
    Wong KK, Sandor GG, Set SS. Isolated haemangioma of the tricuspid valve. Cardiol Young. 2004 Jun;14(3):324.
     
    Khoshhal S, Sandor GG, Duncan WJ. Pulmonary atresia with intact ventricular septum and antenatal left ventricular failure. Cardiol Youn. 2004 June;14(3):335-7.
     
    Barlow AJ, Ward C, Webber SA, Sinclair BG, Potts JE, Sandor GGS. Myocardial contractility in premature neonates with and without patent ductus arteriosus. Pediatr Cardiol. 2004 Mar-Apr;25(2):102-7. Epub 2003 Dec 04.
     
    Rempel GR, Cender LM, Lynam MJ, Sandor GG, Farquharson D. Parents’ perspectives on decision making after antenatal diagnosis of congenital heart disease. J Obstet Gynecol Neonatal Nurs. 2004 Jan-Feb;33(1):64-70.
     
    Sett SS, Mawson JB, Sandro GGS. Repair in Infancy of Right Aortic Arch with Aberrant Brachiocephalic Artery in the setting of a variant of the Hypoplastic Left Heart Syndrome. Cardiology in the Young. 2004;14:441-443.
     
    Sandor GGS, Hishitani T, Petty RE, Potts MT, De Souza A, De Souza E, Potts JE. A novel echo Doppler method of measuring the biophysical properties of the aorta in pediatric patients. J AM SOC Echo 2003;16; 745-750.

    Grants
    Honours & Awards
    Research Group Members

    Members of the Division of Cardiology and Cardiac Surgery

    • Dr. Guy Dumont - Department of Electrical Engineering, University of British Columbia (UBC)
    • Mandel Leung – Postgraduate MSc student, Department of Electrical Engineering, UBC

    Echocardiography Laboratory

     

    • Dr. James Potts – Clinical epidemiologist, Cardiac Sciences Program, BC Children’s Hospital
    • Astrid De Souza – MSc student, School of Kinetics, UBC

    Division of Maternal Fetal Medicine Ultrasound staff, including physicians and technical staff.