• Al-Rawahi, Ghada

    Titles
    Medical Microbiologist

    Investigator, BC Children's Hospital
    Clinical Associate Professor, Medical Microbiology, Department of Pathology & Laboratory Medicine, Faculty of Medicine, UBC

    Degrees / Designations
    MD, DTM&H (London), D(ABMM), FRCPC
    Primary Area of Research
    Evidence to Innovation
    Secondary Area(s) of Research
    Phone
    604-875-2394
    Fax
    604-875-3777
    Lab Phone
    Mailing Address
    BC Children's Hospital
    Room 2G27
    4500 Oak Street

    Vancouver, BC V6H 3N1

    Affiliate Websites
    Research Areas
    • C. difficile infection in children particularly oncology 
    • Candidemia in children
    • Fungal infection in immunocompromised hosts

    Summary
    My current research is focused on Clostridium difficile infection in children with cancer. Clostridium difficile is a common bacterium in the human gut that usually does not cause infection but in certain circumstances can cause diarrhea. It is significant because it can easily spread from patient to patient in hospitals if infection prevention measures and environmental cleaning practices are suboptimal. We have noted that a higher proportion of oncology patients have this infection compared to other hospitalized patients. We aim to determine whether patients get the infection in hospital or if they come to the hospital with it. This information will help us understand the true burden of C. difficile infection in oncology and improve the quality of care provided to these patients.
    Current Projects

    Clostridium difficile in pediatric oncology

    • To determine the prevalence of C. difficile by PCR (toxin gene) in stools from pediatric oncology patients at admission to hospital 
    • To determine the true rate of health care associated C.  difficile infection and community-associated C.  difficile infection in pediatric oncology patients
    • Evaluate the evidence of patient to patient transmission based on typing of C. difficile isolates from pediatric oncology patients, using each patient as their own control
    Candidemia
    • Determine the epidemiology of candidemia in adults and children
    • Determine the incidence of mixed candidemia 
    • Determine the correlation of antifungal susceptibility with clinical outcome
    Selected Publications

    Hasan MR, Tan R, Al-Rawahi GN, Thomas E, Tilley P. Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction. Can J Infect Dis Med Microbiol. 2014 Jul;25(4):217-21. PMID: 25285127

    Himsworth CG, Miller RR, Montoya V, Hoang L, Romney MG, Al-Rawahi GN, Kerr T, Jardine CM, Patrick DM, Tang P, Weese JS. Carriage of methicillin-resistant Staphylococcus aureus by wild urban Norway rats (Rattus norvegicus). PLoS One. 2014 Feb 3;9(2):e87983. doi: 10.1371/journal.pone.0087983. eCollection 2014. PMID: 24498421

    Schutz PW, Fauth CT, Al-Rawahi GN, Pugash D, White VA, Stockler S, Dunham CP. Granulomatous herpes simplex encephalitis in an infant with multicystic encephalopathy: a distinct clinicopathologic entity? Pediatr Neurol. 2014 Apr;50(4):392-6. doi: 10.1016/j.pediatrneurol.2013.12.008. Epub 2013 Dec 14. PMID: 24485930

    Al-Rawahi GN, Roscoe DL. Ten-year review of candidemia in a Canadian tertiary care centre: Predominance of non-albicans Candida species. Can J Infect Dis Med Microbiol. 2013 Fall;24(3):e65-8. PMID: 24421833

    Abeer Al-Najjar, Ghada N. Al-Rawahi, Linda M. Hoang, Tobias R. Clostridium difficile Vertebral Osteomyelitis. Pediatr Infect Dis J. 2013 Sep;32(9):1030-2. doi: 10.1097/INF.0b013e318296b424. PMID: 23594589

    Hasan MR, Brunstein JD, Al-Rawahi G, Tan R, Thomas E, Tilley P. Optimal use of MRSASelect and PCR to maximize sensitivity and specificity of MRSA detection. Curr Microbiol. 2013 Jan;66(1):61-3. PMID: 23053488

    Hasan MR, Tan R, Al-Rawahi GN, Thomas E, Tilley P. Short-term stability of pathogen-specific nucleic acid targets in clinical samples. J Clin Microbiol. 2012 Dec;50(12):4147-50. PMID: 23052319

    Al-Rawahi GN, Dobson SR, Scheifele DW, Rassekh SR, Murphy JJ. Severe Genital Ulceration in an Acute Epstein-Barr Virus Infection. Pediatr Infect Dis J. 2011 Feb;30(2):176-8. PMID: 20736877

    K. A. Cox, G. Al-Rawahi, T. R. Kollmann. Anaerobic Brain Abscess following Chronic Suppurative Otitis Media in a Child from Uganda. Can J Infect Dis Med Microbiol Vol 20 No 3 Autumn 2009. PMID: 20808460

    Leung V, Al-Rawahi GN, Grant J, Fleckenstein L, Bowie W. Case report: failure of subcutaneous ivermectin in treating Strongyloides hyperinfection. Am J Trop Med Hyg. 2008 Dec;79(6):853-5. PMID: 19052292

    Al-Muharrmi Z, Al-Jabri AA, Al-Rawahi G, Scrimgeor EM, Al-Marhobi A. HIV-1 Viral Load After Leukodepletion. J Acquir Immune Defic Syndr. 2008 Jun 1;48(2):224-225. PMID: 18520683

    Luong ML, Békal S, C Vinh D, Lauzon D, Leung V, Al-Rawahi GN, Ng B, Burdz T, Bernard K. First Report and Characterization of Aurantimonas altamirensis in Clinical Samples. J Clin Microbiol. 2008 May 21. PMID: 18495852

    Al-Rawahi GN, Reynolds S, Porter SD, Forrester L, Kishi L, Chong, T, Bowie WR, Doyle PW. CMRSA-10 (USA-300) is the Predominant Strain among MRSA Strains Causing Skin and Soft Tissue Infections in Patients Presenting to the Emergency Department of a Tertiary Care Hospital, Vancouver, BC, Canada. J Emerg Med. 2008 Mar 4.

    Al-Rawahi GN, Schreader AG, Porter SD, Roscoe DL, Gustafson R, Bryce EA. Methicillin-Resistant Staphylococcus aureus Nasal Carriage among Injection Drug Users: Six Years Later. J Clin Microbiol. 2008 Feb;46(2):477-9. PMID: 18039800
    Grants

    BC Children's Hospital. Project: "Health-care associated C. difficile Infection in Pediatric Oncology." With S. Dobson. A. Al-Najjar, R. Deyell, E. Thomas, P. Tilley. 2013.

    BC Children's Hospital. Project: "Detection of toxigenic Clostridium difficile in Pediatrics: Evaluation of Four Different Methods." With P. Tilley. 2010.

     

     

    Honours & Awards
    Research Group Members