• Nadel, Helen

    Titles

    Investigator, BC Children's Hospital 
    Pediatric Radiologist, BC Children's Hospital
    Associate Professor, Department of Radiology, University of British Columbia

    Degrees / Designations

    MD

    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-3034
    Fax
    Lab Phone
    Mailing Address

    Department of Radiology, BC Children's Hospital
    Room 1K19
    4480 Oak St
    Vancouver, BC, V6H 3V4

    Affiliate Websites
    Research Areas
    • Pediatrics
    • Pediatric Radiology
    • Nuclear Medicine
    • Hybrid Imaging
    • PET/CT
    • Cancer
    Summary

    My research looks at how diagnostic imaging studies can help doctors determine which areas of their bodies are involved with a specific disease. Then, after they treat the disease, they can use the same imaging studies to find out how well their treatment has done to irradiate the disease.

    Current Projects

    Review of a 12 year experience of diagnostic optimized PET/CT in pediatrics. We have chosen to perform our PET/CT studies with low dose CT techniques and after the injection of intravenous contrast enhancement. This allows the patient to have a complete 'one stop' diagnostic study for mainly tumor evaluation that includes an optimized cross-sectional imaging study. This obviates the need for a second body imaging cross-sectional study. We are reviewing our solid tumor experience to determine the added value of this approach. In addition, part of this evaluation will determine the radiation savings of using lower dose CT parameters and what potential pitfalls there may be for using this technique.

    In our pediatric lymphoma patients, we are seeking to validate FDG-PET/CT for tumor response assessment in intermediate grade disease and its value in response-adapted therapy. I am also looking at a subset of sarcoma patients to determine the validity of using PET/CT and the timing of studies as a surrogate marker for histologic tumor response.

    The use of I-123 mlBG optimized SPECT/CT in neuroblastoma. This study evaluates the use of optimized diagnostic CT with mIBG SPECT studies to determine if there is better localization and increased sensitivity and specificity of lesion detection using this hybrid technique.

    Validation of the use of DXA to determine fracture risk in children on steroids as part of Canadian longitudinal STOPP study as well as looking at value of DXA in children with chronic disease.

    Selected Publications

    Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G, Kager L, Kuehne T, Lau C,Letson GD, Meyer J, Meyers P, Morris C, Mottl H, Nadel H, Nagarajan R, Randal RL, Schomberg P, Schwarz R, Teot LA, Sydes MR, Bernstein M; on behalf of the EURAMOS collaborators. EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment. Ann Oncol. 2014 Nov 24. pii: mdu526. [Epub ahead of print] PubMed PMID: 25421877.

    Ma J, Siminoski K, Alos N, Halton J, Ho J, Lentle B, Matzinger M, Shenouda N, Atkinson S, Barr R, Cabral DA, Couch R, Cummings EA, Fernandez CV, Grant RM, Rodd C, Sbrocchi AM, Scharke M, Rauch F, Ward LM; Canadian STOPP Consortium. The choice of normative pediatric reference database changes spine bone mineral density Z-scores but not the relationship between bone mineral density and prevalent vertebral fractures. J Clin Endocrinol Metab. 2015 Mar;100(3):1018-27. doi: 10.1210/jc.2014-3096. Epub 2014 Dec 11. PubMed PMID: 25494661; PubMedCentral PMCID: PMC4519277.

    Jaremko JL, Siminoski K, Firth GB, Matzinger MA, Shenouda N, Konji VN, Roth J, Sbrocchi AM, Reed MH, O'Brien MK, Nadel H, McKillop S, Kloiber R, Dubois J, Coblentz C, Charron M, Ward LM; Canadian STOPP Consortium National Pediatric Bone Health Working Group. Common normal variants of pediatric vertebral development that mimic fractures: a pictorial review from a national longitudinal bone health study. Pediatr Radiol. 2015 Apr;45(4):593-605. doi: 10.1007/s00247-014-3210-y.Epub 2015 Apr 1. PubMed PMID: 25828359; PubMed Central PMCID: PMC4519278.

    Bielack SS, Smeland S, Whelan JS, Marin N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Letson GD, Teot LA, Goorin A, Baumhoer D, Kager L, Werner M, Lau CC, Sundby Hall K, Gelderblom H, Meyers P, Gorlick R, Windhager R, Helmke K, Eriksson M, Hoogerbrugge PM, Schomberg P, Tunn PU, Kühne T, Jürgens H, van den Berg H, Böhling T, Picton S, Renard M, Reichardt P, Gerss J, Butterfass-Bahloul T, Morris C, Hogendoorn PC, Seddon B, Calaminus G, Michelagnoli M, Dhooge C, Sydes MR, Bernstein M; EURAMOS-1 investigators. Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial. J Clin Oncol. 2015 Jul 10;33(20):2279-87. doi: 10.1200/JCO.2014.60.0734. Epub 2015 Jun 1. PubMed PMID: 26033801; PubMed Central PMCID: PMC4486345.

    LeBlanc CM, Ma J, Taljaard M, Roth J, Scuccimarri R, Miettunen P, Lang B,Huber AM, Houghton K, Jaremko JL, Ho J, Shenouda N, Matzinger MA, Lentle B, Stein R, Sbrocchi AM, Oen K, Rodd C, Jurencak R, Cummings EA, Couch R, Cabral DA,Atkinson S, Alos N, Rauch F, Siminoski K, Ward LM; Canadian STeroid- AssociatedOsteoporosis in Pediatric Population (STOPP) Consortium. Incident Vertebral Fractures and Risk Factors in the First Three Years Following Glucocorticoid Initiation Among Pediatric Patients With Rheumatic Disorders. J Bone Miner Res. 2015 Sep;30(9):1667-75. doi: 10.1002/jbmr.2511. Epub 2015 May 26. PubMed PMID: 25801315; PubMed Central PMCID: PMC4556451.

    Teoh CW, Nadel H, Armstrong K, Harris KC, White CT. Peritoneal-pericardial communication in an adolescent on peritoneal dialysis. Pediatr Nephrol. 2016 Jan;31(1):153-6. 2015 Sep 19. [Epub ahead of print] PubMed PMID: 26386589.

     De Palma D, Nadel HR, Bar-Sever Z. Skeletal scintigraphy with SPECT/CT in benign pediatric bone conditions. Clinical and Translational Imaging. 2016:1-11. doi:10.1007/s40336-016-0169-8.

    Moghbel M, Kostakoglu L, Zukotynski K, Chen DL, Nadel H, Niederkohr RD, Mittra ES. Response Assessment Criteria and their Applications in Lymphoma: Part 1. J Nucl Med. 2016 Apr 28. pii: jnumed.115.166280. [Epub ahead of print] PubMed PMID:27127227.

    Foran AE, Nadel HR, Lee AF, Savage KJ, Deyell RJ. Nivolumab in the Treatment of Refractory Pediatric Hodgkin Lymphoma. J Pediatr Hematol Oncol. 2016 Nov 10.[Epub ahead of print] PubMed PMID: 27841828.

    Moghbel MC, Mittra E, Gallamini A, Niederkohr R, Chen DL, Zukotynski K, Nadel H, Kostakoglu L. Response Assessment Criteria and Their Applications in Lymphoma:Part 2. J Nucl Med. 2017 Jan;58(1):13-22. doi: 10.2967/jnumed.116.184242. Review.PubMed PMID: 27879369.

    Grants

    2013-2014     Using imaging to reduce chemotherapy side-effects in children and adolescents with cancer. BC Children's Hospital Telethon Grant Award.     $28,561 (C)

    2014     Subaward for diagnostic imaging. Children's Oncology Group. National Cancer Institute, National Institutes of Health.   $4,800 (C)

    2015     Subaward for diagnostic imaging. Children's Oncology Group. National Cancer Institute, National Institutes of Health.   $4,800 (C)

    2016    Subaward for diagnostic imaging. Children's Oncology Group. National Cancer Institute, National Institutes of Health.   $4,800 (C)

    2016     Role of [18F] FDG PET/CT in the staging of pediatric malignant germ cell tumours. Rare Disease Foundation. $3,500 (C)

    Honours & Awards

    Recipient, 1993-1994 Teaching Excellence Award, University of British Columbia Nuclear Medicine Residency Training Program.

    Recipient, 1999-2000 with the other 7 pediatric radiologists at BCCH of UBC Radiology Residency Award for Excellence in Teaching.

    Recipient, 2001 with the other 7 pediatric radiologists at BCCH of Wyeth Excellence in Teaching Award, the most valuable teaching service award, by the Department of Pediatrics, UBC. The award is presented to the teaching service (Radiology), voted by Fourth Year Medical Students as the most valuable educational experience.

    Preliminary Experience Using PET-CT in Pediatric Bone and Soft Tissue Tumors H Nadel , AT Byrne, M Webber, C. Senger, R. Rassekh, K Brown, won best poster at the 6th European Association of Pediatric Nuclear Medicine, Platja d’Aro, Spain, May 2008

    Pediatric Chest X-ray Findings Guide Wise Choices for Secondary Investigation. Naoya Shatani, medical student, Co-authors Drs Bray, Nadel and Potts, won First Place for Educational Exhibits Contest, Canadian Association of Radiologists Annual Meeting, Montreal, PQ, April 2016

    Not Just Nodes! Imaging Review of the Pulmonary Manifestations of Pediatric Lymphoma and Lymphoma-like Disorders, Liang, T, Nadel HR, Bray H, RSNA 2016 Educational Exhibit Certificate of Merit

    Mickey (Cardiff) Williams Distinguished Service Award Western Regional Society of Nuclear Medicine and Molecular Imaging. Presented at the 39th Annual Western Regional Meeting Society of Nuclear Medicine and Molecular Imaging, Seattle, Washington, October 31, 2014

    Research Group Members

    Rebecca Eyell, Pediatric Oncologist 
    Jim Potts, Research Coordinator, Pediatric Radiology