• Hildebrand, Kyla J.

    Titles

    Investigator, BC Children's Hospital
    Clinical Assistant Professor, Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia

    Degrees / Designations

    MD, FRCPC, MScCH (HPTE)

    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    (604) 875-2118
    Fax
    (604) 875-3653
    Lab Phone
    Assistant
    Lisa Wilson
    Assistant Phone
    (604) 875-2118
    Mailing Address

    BC Children's Hospital
    Room 1C31B
    4480 Oak Street
    Vancouver, BC V5Z 4H4

    Affiliate Websites
    Research Areas
    • Food Allergy
    • Primary Immunodeficiency
    • Severe Asthma
    Summary

    My research interests are in the area of Allergy and Clinical Immunology. The immune system plays a critical role in protecting hosts from infection. Primary immunodeficiency encompasses a group of disorders whereby parts of the immune system may be defective or missing, often resulting in severe, invasive or recurrent infections, autoimmunity and malignancy. The genetic makeup of an individual and the response of the immune system to external environmental factors can result in allergic disorders and disease. There is a strong relationship between conditions such as asthma, food allergy and atopic dermatitis - all of which have an underlying immunological basis. My research aims to study these disorders and apply knowledge translation strategies to empower patients, families and their physicians.

    Current Projects

    The CHILD study: this study is a multicenter, multidisciplinary, longitudinal, population-based cohort study of 5000 children. The aim of the study is to test multiple hypotheses within the theme that specific environmental exposures along with genetic and immunological determinants, lead to pathophysiological allergic responses, and that clinical outcomes including asthma may be further modified by lung growth, hormonal and metabolic influences and psychosocial environment. Children were recruited from 4 cities in Canada, including Vancouver and are being followed prospectively.

    Certified Asthma Educator (CAE) Anaphylaxis Counseling Study: Several of my research projects involve studying the relationship between asthma, allergy and anaphylaxis. Many patients with severe asthma who require admission to intensive care units or repeated hospital admissions have underlying allergic triggers (environmental or food allergy). Poorly controlled asthma is a significant risk factor for anaphylaxis in this patient population. I am assessing the frequency of anaphylaxis counseling performed by a group of CAEs at BC Children’s Hospital and the outcomes associated with this counseling intervention. For patients living in remote areas of British Columbia, there is greater accessibility to CAEs in comparison to pediatric asthma/allergy specialists. There may be a role for curricular innovation to the CAE training programs across Canada to better serve this at-risk patient population.

    Epinephrine Autoinjector Study: Caregivers and patients in Pediatric Allergy Clinic often report that they are fearful of using an epinephrine autoinjector despite receiving education on indications for use and technique. Given that intramuscular epinephrine is the only medication that can reverse a potentially severe allergic reaction, it is very important that patients and caregivers possess not only the knowledge and ability to use epinephrine autoinjectors, but also have the confidence to administer the medication when clinically indicated. The goal of the Epinephrine Autoinjector study is to assess the impact of self or caregiver-administrated epinephrine in a medically supervised setting on the confidence of patient and/or caregivers for future use of epinephrine autoinjector.

    Selected Publications

    Grazioli S, Bennett M, Hildebrand KJ, Vallence H, Turvey SE, Junker A. Limitation of TREC-based newborn screening for Zap70 immunodeficiency.  Clinical Immunology. 2014; 153(1): 209-10. PMID: 24797280

    Hildebrand KJ, Atkinson A, Kitai I. Rifampin hypersensitivity in a 2 year old child with successful rapid oral desensitization. Pediatric Infectious Disease Journal 2014; 33(7): 787. PMID: 24918746

    Wong T, Yeung J, Hildebrand KJ, Junker AK, Turvey SE. Human Primary immunodeficiencies causing defects in innate immunity. Current Opinion in Allergy and Clinical Immunology. 2013 Dec;13(6): 607-13. PMID: 24126612 

    Grants
    Honours & Awards

    Royal College of Physicians and Surgeons Canada Fellowship for Studies in Medical Education (2010)

    Research Group Members