• Provençal, Nadine

    Titles

    Investigator, BC Children's Hospital
    Assistant Professor, Faculty of Health Sciences, Simon Fraser University

    Degrees / Designations

    Ph.D.

    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Origins of Child Health and Disease Research Group
    Phone
    778-782-5171
    Fax
    Lab Phone
    Mailing Address

    BC Children's Hospital
    Room A4 - 193
    950 West 28th Avenue
    Vancouver, BC V5Z 4H4

    Affiliate Websites
    Research Areas
    • Epigenomics
    • Biological embedding of early life exposures
    • Genes and environment interactions
    • Developmental trajectories of health and diseases
    • Stress hormones regulation of gene expression
    • Behavioral and psychiatric disorders
    • Child development 
    Summary
    Current Projects
    Selected Publications

    Piyasena C, Cartier J, Provençal N, Wiechmann T, Khulan B, Sunderasan R, Menon G, Seckl JR, Reynolds RM, Binder EB, Drake AJ. Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants. Front Endocrinol, Dec 2016, 15;7:158.

    Laura Hack, Alec Dick and Nadine Provençal. Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine. Environmental Epigenetics. Aug 2016, 2 (3): dvw016.

    Nadine Provençal and Elisabeth B Binder. The effects of early life stress on the epigenome: From the womb to adulthood and even before. Experimental Neurology, June 2015, 268:10-20.

    Nadine Provençal and Elisabeth B Binder. The neurobiological effects of stress as contributors to psychiatric disorders: focus on epigenetics. Current Opinion in Neurobiology, February 2015, 30:31-37.

    Nadine Provençal, Linda Booij and Richard E. Tremblay. The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity. Journal of Experimental Biology, January 2015, 218(Pt 1):123-33.

    Renaud Massart, Matthew J. Suderman, Nadine Provençal, Cao Yi, Angela Ruggiero, Allyson J. Bennett, Peter J. Pierre, David P. Friedman, Stephen Suomi and Moshe Szyf. Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation. Neuroscience, May 2014, 268:139-48

    Nadine Provençal, Matthew J. Suderman, Claire Guillemin, Dongsha Wang, Frank Vitaro, Sylvana M. Côté, Michael Hallett, Richard E. Tremblay and Moshe Szyf. Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells. PLoS One, April 2014, 9(4): e89839.

    Nadine Provençal, Matthew J. Suderman, Dongsha Wang, Doretta Caramaschi, Frank Vitaro, Sylvana M. Côté, Michael Hallett, Richard E. Tremblay and Moshe Szyf. Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression. PLoS One, August 2013, 8(8): e71691.

    Nadine Provençal, Matthew J. Suderman, Claire Guillemin, Dongsha Wang, Angela Ruggiero, Allyson J. Bennett, Peter J. Pierre, David P. Friedman, Sylvana M. Côté, Michael Hallett, Richard E. Tremblay, Stephen J. Suomi and Moshe Szyf. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. Journal of Neurosiences, 2012, Oct 31;32(44):15626-42.

    Dongsha Wang, Moshe Szyf, Chawki Benkelfat, Nadine Provençal, Gustavo Turecki, Doretta Caramaschi, Sylvana M. Côté, Frank Vitaro, Richard E. Tremblay and Linda Booij. Epigenetic biomarkers in blood cells for physical aggression and the serotonin pathway. PLoS One, June 2012;7(6):e39501.

    Full list of publications can be found here.

    Grants

    Brain & Behavior Research Foundation: NARSAD Young Investigator Grant  2017-2019

    Bell Grant: Access to the Signature Biobank 2015-2016 

    Honours & Awards

    Fellowship Award, Canadian Institute of Health Research (CIHR) 2015-2017

    Richard Todd Award, International Society of Psychiatric Genetics 2014

    Research Group Members