• Broady, Raewyn

    Titles

    Affiliate Investigator, BC Children's Hospital
    Clinical Associate Professor, Division of Hematology, Department of Medicine, Faculty of Medicine, University of British Columbia

    Degrees / Designations
    MBChB, FRACP, FRPCA, FRCPC
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-4763
    Fax
    604-875-4863
    Lab Phone
    Assistant
    Joanna Faulks
    Assistant Phone
    604-875-5320
    Mailing Address

    Vancouver General Hospital, 10th Floor
    2775 Laurel Street
    Vancouver, BC V5Z 1M9

    Affiliate Websites
    Research Areas
    • Transplantation tolerance
    • T regulatory cells 
    Summary

    Graft versus host disease (GvHD) is a life-threatening complication that occurs in a majority of patients undergoing a bone marrow transplants from an alternative donor. GvHD occurs when donor T cells recognize host tissues as foreign.  My research is understanding how a special subset of T cells, named T regulatory cells (Tregs), can control this process. A long term goal is to generate Tregs in the laboratory for use as a cellular therapy to prevent GvHD.

    Current Projects
    • Studying tissue derived Tregs from patients with GvHD
    • Developing biomarkers to predict which patients will develop GvHD
    • Developing methods to use Tregs as a cellular therapy 
    Selected Publications

    Broady, R & Levings MK. Graft-versus-host disease: suppression by statins. Nat Med. 2008 Nov;14(11):1155-6. PMID: 18989280.

    Allan, SE., Broady, R., Gregori, S., Himmel, ME, Locke, N., Roncarolo, MG, Bacchetta, R. and Levings, MK. CD4+ T regulatory cells: towards therapy for human diseases. Immunological Reviews. 2008, 223:391-421. PMID: 18613849.

    Broady, R., Yu, J. and Levings. ATG-induced expression of FOXP3 in human CD4(+) T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells. Blood. 2009 Dec 3;114(24):5003-5006. PMID: 19822903.

    Crome SQ, Clive B, Wang AY, Kang CY, Chow V, Yu J, Lai A, Ghalmary A, Broady R & Levings M. The inflammatory effects of ex vivo human T helper 17 cells are suppressed by T regulatory cells. Journal of Immunology, 2010 185(6). PMID: 20720207.

    Broady, R., Yu, J, Chow, V. Tantiworiwat, A., Kang, C., Berg, K.B., Martinka, M., Ghoreishi, M., Dutz, J., and Levings, M.K. Cutaneous GVHD is associated with the expansion of tissue localised Th1 and not Th17 cells. Blood Dec 2010: 116(25):5748-51. PMID: 20864580.

    Yu R, Broady R, Huang Y, Wang Y, Yu J, Gao M, Levings M, Wei S, Zhang S, Xu A, Su M, Dutz J, Zhang X, Zhou Y. Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin. PLoS One. 2012;7(12):e51040.doi10.1371/journal.pone.0051040. Epub 2012 Dec 10. PMID: 23251420

    Grants

    Canadian Institutes of Health Research Operating Grant: The role of FOXP3 and IL-1-family cytokines in regulating CD4+ T cell subsets in healthy humans, and in patients with chronic skin inflammation. Co-applicant   (2013-2016)

    Leukemia & Lymphoma Society of Canada: The effect of ATG on immune reconstitution post HSCT. Principal Applicant (2013-2015) 

    Canadian Cancer Society Research Institute Innovative Grant: Generation of antigen specific T regulatory cells to treat GVHD post allogeneicstem cell transplant. Principal Applicant (2013-2015)

    Canadian Institutes of Health Research Operating Grant: Molecular and Cellular Biology of Th17 cells in health and disease. Co-applicant (2009 - 2013) 

    Galloway Leukemia Research Seed Funding, University of British Columbia: The impact of Regulatory T cells on Graft versus Leukemia responses.  Prinicpal Applicant. (2010-2012)

    Canadian Institutes of Health Research Operating Grant: Biomarkers in chronic GVHD.  Co-applicant (2009- 2012)  

    Honours & Awards

    Academic Enhancement Fund Award,  2008 – 2010

    VCHRI Global Collaboration Research Award,  2007

    ”In it for life” Mentored Clinician Scientist Award,  2005-2007

    Amgen Travelling Scholarship Research Award,  2002

    Associazione di Paolo Belli Borsa di Studio,  2001

    Research Group Members
    • Jessica Huang
    • Katherine MacDonald
    • Nicholas Dawson