• Murthy, Srinivas

    Titles

    Investigator, BC Children's Hospital
    Clinical Assistant Professor, Department of Pediatrics, University of British Columbia

    Degrees / Designations

    MD, CM

    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-2778
    Fax
    Lab Phone
    Mailing Address

    Division of Critical Care 
    BC Children's Hospital
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Acute infections
    • Health services research
    • International health
    Summary

    Infections in children are still a major cause of early morbidity and mortality throughout the world, despite the advances made in preventive care. Infections are often a reason for children to become critically ill, and often occur in the critically ill child. My research focuses upon stemming this burden through optimizing their management in a variety of settings. Additionally, the ability of various settings and healthcare systems to cost-effectively manage critically ill children, especially those with infection, is an area of focus.

    Current Projects
    Biomarkers in pediatric sepsis

    Being able to stratify children with severe sepsis, so as to better triage their care and predict their outcome, is a long‐standing challenge. I am investigating the role of a panel of novel biomarkers, detected in blood, in predicting the outcome of children. This will be of tremendous help for research purposes, for front‐line providers assessing the severity of illness, and for improving the understanding of the mechanism of the complex septic reaction.

    Selected Publications

    Austin S, Murthy S, Wunsch H, Adhikari NK, Karir V, Rowan K, Jacob ST, Salluh J, Bozza F, Du B, An Y, Lee B, Wu F, Oppong C, Venkataraman R, Velayutham V, Angus DC; Variation in acute care burden and supply across diverse urban settings. Intesive Care Medicine (in press)

    Srinivas Murthy, Neill Adhikari. ATS reports: Global Health Care of the Critically Ill. Annals of the American Thoracic Society. 2013 10(5):509-513

    Srinivas Murthy, Keystone J, Kissoon N. Lethal Infections of Developing Countries. Critical Care Clinics 2013 July, 29 (3): 485-507

    Dos Santos C, Murthy S, Hu P, Shan Y, Haitsma JJ, Mei SHJ, Stewart DJ, Liles WC. Network Analysis of Transcriptional Responses Induced by Systemic Administration of Bone Marrow Derived Mesenchymal Cells in Polymicrobial Sepsis. American Journal of Pathology 2012 Nov;181(5):1681-92

    Bourgeois, F, Murthy S, Ioannidis J, Mandl K. Pediatric versus Adult Drug Trials for Conditions with High Pediatric Disease Burden: Analysis of Registered Trials, 2006-2011. Pediatrics 2012 Aug;130(2):285-92.

    Srinivas Murthy, Wunsch H. International Comparisons in Critical Care: Lessons Learned. Critical Care 2012 Apr; 16:218

    Srinivas Murthy, Xing K, Liles WC, Singh J. Clinical Utility of Biomarkers of Endothelial Activation in Sepsis - A Systematic Review. Critical Care 2012:16 R7

    Grants
    • 2011 University of Toronto Elizabeth Arbuthnot Dyson Fellowship
    • 2011 University of Toronto Joseph M. West Family Memorial Fund Fellowship

    Honours & Awards
    Research Group Members