• Rakic, Bojana

    Titles

    Investigator, BC Children's Hospital
    Clinical Assistant Professor, Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia
    Biochemical Geneticist, Newborn Screening and Biochemical Genetics Labs,
    Department of Pathology & Lab Medicine, BC Children’s Hospital

    Degrees / Designations

    PhD, FCCMG

    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-3633
    Fax
    Lab Phone
    Mailing Address

    BC Children's Hospital
    4480 Oak Street, Room 2F3
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Clinical application of mass spectrometry for diagnosing inborn errors of metabolism
    • Case investigation of novel genes implicated in inborn errors of metabolism
    Summary

    My research focuses on clinical applications of mass spectrometry, including the development of plasma and urine amino acid methods for diagnosis of inborn errors of metabolism. 

    I am actively involved in the validation of new technologies and assays for use in biochemical genetics and newborn screening laboratories.

    Current Projects
    Selected Publications
    Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Ye XC, Zhang LH, Bhavsar AP, Lee JJ, Drögemöller BI, Abdelsayed M, Alfadhel M, Armstrong L, Baumgartner MR, Burda P, Connolly MB, Cameron J, Demos M, Dewan T, Dionne J, Evans AM, Friedman JM, Garber I, Lewis S, Ling J, Mandal R, Mattman A, McKinnon M, Michoulas A, Metzger D, Ogunbayo OA, Rakic B, Rozmus J, Ruben P, Sayson B, Santra S, Schultz KR, Selby K, Shekel P, Sirrs S, Skrypnyk C, Superti-Furga A, Turvey SE, Van Allen MI, Wishart D, Wu J, Wu J, Zafeiriou D, Kluijtmans L, Wevers RA, Eydoux P, Lehman AM, Vallance H, Stockler-Ipsiroglu S, Sinclair G, Wasserman WW, van Karnebeek CD. Exome Sequencing and the Management of Neurometabolic Disorders. N Engl J Med. 2016 Jun 9;374(23):2246-55. PMID: 27276562

    Rakic B, Rao FV, Freimann K, Wakarchuk WW, Strynadka NCJ, Withers SG. Structure-based Mutagenic Analysis of Mechanism and Substrate Specificity in Mammalian Glycosyltransferases: Porcine ST3Gal-I. Glycobiology. 2013 May;23(5):536-45. PMID: 23300007

    Lin LY, Rakic B, Chiu CP, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis. J Biol Chem. 2011 Oct 28;286(43):37237-48. PMID: 21880735

    Rao FV, Rich JR, Rakić B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC. Structural insight into mammalian sialyltransferases. Nat Struct Mol Biol. 2009 Nov;16(11):1186-8. PMID: 19820709

    Lee HJ, Rakić B, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic characterizations of the polysialic acid O-acetyltransferase OatWY from Neisseria meningitidis. J Biol Chem. 2009 Sep 4;284(36):24501-11. PMID: 19525232

    Rakic B, Withers SG. Recent developments in glycoside synthesis with glycosynthases and thioglycoligases. Australian Journal of Chemistry 62: 510-520, 2009. PMID: 19525232

    Lorello GR, Legault MC, Rakić B, Bisgaard K, Pezacki JP. Synthesis and bioorthogonal coupling chemistry of a novel cyclopentenone-containing unnatural tyrosine analogue. Bioorg Chem. 2008 Apr;36(2):105-11. PMID: 18272199  

    Nandy JP, Rakic B, Sarma BV, Babu N, Lefrance M, Enright GD, Leek DM, Daniel K, Sabourin LA, Arya P. Benzofuran-derived cyclic beta-amino acid scaffold for building a diverse set of flavonoid-like probes and the discovery of a cell motility inhibitor. Org Lett. 2008 Mar 20;10(6):1143-6. PMID: 18302395

    Rakic B, Clarke J, Tremblay TL, Taylor J, Schreiber K, Nelson KM, Abrams SR, Pezacki JP. A small-molecule probe for hepatitis C virus replication that blocks protein folding. Chem Biol. 2006 Oct;13(10):1051-60. PMID: 17052609

    Rakić B, Brûlotte M, Rouleau Y, Bélanger S, Pezacki JP. Bleomycin is a potent small-molecule inhibitor of hepatitis C virus replication. Chembiochem. 2006 Sep;7(9):1330-3. PMID: 16888741

    Rakic B, Sagan SM, Noestheden M, Bélanger S, Nan X, Evans CL, Xie XS, Pezacki JP. Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication. Chem Biol. 2006 Jan;13(1):23-30. PMID: 16426968

    Grants

    Rare Disease Foundation and BC Children’s Hospital Foundation (BCCHF): GBA2 validation, $3500. Coinvestigator: Dr. Gabriella Horvath

    Rare Diseases: Models and Mechanisms Network: N-Acetylneuraminate pyruvate lyase (NPL) deficiency Functional validation in mouse, $20,000. Conivestigators: Dr. Clara van Karnebeek and Dr. Alexey Pshezhetsky

    Honours & Awards
    2014 - Linda Stevens Memorial Fund Garrod Conference Travel Award 2014

    2009-2012 - NSERC Postdoctoral Fellowship

    2005 - Pfizer Award for Outstanding Achievement, Bio-Organic Gordon Research Conference

    2005 - Best Graduate Student Oral Presentation, Biological/Medicinal section, CSC Conference

    2004 - Tito Scaiano International Student Award for Academic Excellence

    2001 - Best Chemistry Student Award, Office of the Rector, University of Belgrade
      

    2001 - Student of the Generation Award, Department of Chemistry, University of Belgrade

    Research Group Members