Overview

There is increasing evidence to suggest that intestinal inflammation affects the organization and function of the intestinal nervous system, which controls how our intestine works. As a result, changes in nerve function may alter how the inestine works, worsen inflammation and aggravate the symptoms in IBD. In our studies we are examining the nerve-intestinal lining responses to inflammation in animal models if IBD and in our children with IBD. We will determine what nerve changes occur in assoications with intestinal inflammation, how these changes affectr the function of the intestinal lining cells and whether these changes persist. We will also examine the potential benfit of probiotics (living non-harmful bacteria).

We are also examining the effects of maternal dietary fat on intestinal lining cells (which protect the host from harmful dietary agents and infectious organisms) and on the intestinal immune response in young offspring.

Publications

Adalimumab vs Infliximab in Luminal Pediatric Crohn's Disease: Comparable Outcomes in a Prospective Multicenter Cohort Study
American Journal of Gastroenterology
Jennifer C. deBruyn and Hien Q. Huynh and Anne M. Griffiths and Kevan Jacobson and David Mack and Colette Deslandres and Wael El-Matary and Anthony R. Otley and Peter C. Church and Sally Lawrence and Eytan Wine and Mary Sherlock and Jeffrey Critch and Eric I. Benchimol and Prévost Jantchou and Mohsin Rashid and Matthew W. Carroll and Kevin Bax and Amanda Ricciuto and Nicholas Carman and Thomas D. Walters
DOI: 10.14309/ajg.0000000000002552
03/2024

Forecasting the Incidence and Prevalence of Inflammatory Bowel Disease: A Canadian Nationwide Analysis
American Journal of Gastroenterology
Stephanie Coward and Eric I. Benchimol and Charles N. Bernstein and Antonio Avina-Zubieta and Alain Bitton and Matthew W. Carroll and Yungsong Cui and Frank Hoentjen and Lindsay Hracs and Kevan Jacobson and Jennifer L. Jones and James King and M. Ellen Kuenzig and Na Lu and Wael El-Matary and Sanjay K. Murthy and Zoann Nugent and Anthony R. Otley and Remo Panaccione and Juan Nicolás Peña-Sánchez and Harminder Singh and Laura E. Targownik and Dominic White and Joseph W. Windsor and Gilaad G. Kaplan
DOI: 10.14309/ajg.0000000000002687
03/2024

Insights Into Inflammatory Bowel Disease and Effects of Dietary Fatty Acid Intake With a Focus on Polyunsaturated Fatty Acids Using Preclinical Models
Journal of the Canadian Association of Gastroenterology
Matthew Smyth and Genelle Lunken and Kevan Jacobson
DOI: 10.1093/jcag/gwad058
02/2024

Health Services Utilization and Specialist Care in Pediatric Inflammatory Bowel Disease: A Multiprovince Population-Based Cohort Study
Inflammatory Bowel Diseases
M Ellen Kuenzig and Alain Bitton and Matthew W Carroll and Anthony R Otley and Harminder Singh and Gilaad G Kaplan and Therese A Stukel and David R Mack and Kevan Jacobson and Anne M Griffiths and Wael El-Matary and Laura E Targownik and Geoffrey C Nguyen and Jennifer L Jones and Sanjay K Murthy and Charles N Bernstein and Lisa M Lix and Juan Nicolás Peña-Sánchez and Trevor J B Dummer and Sarah Spruin and Stephen G Fung and Zoann Nugent and Stephanie Coward and Yunsong Cui and Janie Coulombe and Christopher Filliter and Eric I Benchimol
DOI: 10.1093/ibd/izae010
02/2024

A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial
Journal of Crohn's and Colitis
Natasha Haskey and Mehrbod Estaki and Jiayu Ye and Rachel K Shim and Sunny Singh and Levinus A Dieleman and Kevan Jacobson and Deanna L Gibson
DOI: 10.1093/ecco-jcc/jjad073
11/2023

Outcomes following acute severe colitis at initial presentation: a multi-centre prospective paediatric cohort study
Jasbir dhaliwal and Dominique Tertigas and Nicholas Carman and Hien Huynh and Wael El-Matary and Jeffrey Critch and Mike Surette and Kevan Jacobson and Aleixo Muise and Jennifer deBruyn and Anne Griffiths and Eytan Wine and Bruce Vallance and Sally Lawrence and Anthony Otley and Mohsin Rashid and Thomas Walters and David Mack and Amanda Ricciuto and Eric Benchimol and Peter Church and Colette Deslandres and Matthew Carroll
DOI: 10.1093/ecco-jcc/jjad143
08/2023

Highly Sensitive, Flow Cytometry-Based Measurement of Intestinal Permeability in Models of Experimental Colitis
Cellular and Molecular Gastroenterology and Hepatology
Tsai, K. and Ma, C. and Han, X. and Allaire, J. and Healey, G.R. and Crowley, S.M. and Yu, H. and Jacobson, K. and Xia, L. and Priatel, J.J. and Vallance, B.A.
DOI: 10.1016/j.jcmgh.2022.10.004
2023

Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives
Gastroenterology
DOI: 10.1053/j.gastro.2023.05.032
2023

Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease
World Journal of Gastroenterology
DOI: 10.3748/wjg.v29.i23.3688
2023

Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis
Gut
DOI: 10.1136/gutjnl-2022-328421
2023

User testing to inform modification of the MyHealthyGut digital health application in inflammatory bowel disease
medRxiv
DOI: 10.1101/2023.03.23.23287648
2023

Inflammatory Bowel Disease Among Canadian Children: Comparison Between Children of Non-European Descent and Children of European Descent
Inflammatory Bowel Diseases
DOI: 10.1093/ibd/izac276
2023

Anti-Integrin avß6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis
Gastroenterology
DOI: 10.1053/j.gastro.2022.12.042
2023

Transition Readiness in Youth with Inflammatory Bowel Disease
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2023.113403
2023

User testing to modify the MyHealthyGut digital health application for inflammatory bowel disease
Digital Health
DOI: 10.1177/20552076231203664
2023

Antibody response to the BNT162b2 SARS-CoV-2 vaccine in paediatric patients with inflammatory bowel disease treated with anti-TNF therapy
Gut
Zahra Jama Shire and Frederic Reicherz and Sally Lawrence and Harjeev Sudan and Liam Golding and Abdelilah Majdoubi and Paul N Levett and Pascal M Lavoie and Kevan Jacobson
DOI: 10.1136/gutjnl-2021-326196
09/2022

Canadian Consensus Statements on the Transition of Adolescents and Young Adults with Inflammatory Bowel Disease from Pediatric to Adult Care: A Collaborative Initiative Between the Canadian IBD Transition Network and Crohn’s and Colitis Canada
Journal of the Canadian Association of Gastroenterology
Nancy Fu and Natasha Bollegala and Kevan Jacobson and Karen I Kroeker and Karen Frost and Waqqas Afif and Wael El-Matary and Sharyle A Fowler and Anne M Griffiths and Hien Q Huynh and Prévost Jantchou and Ahmer Karimuddin and Geoffrey C Nguyen and Anthony R Otley and Christina Pears and Cynthia H Seow and Alene Toulany and Claudia Tersigni and Joanne Tignanelli and John K Marshall and Monica Boctor and Tawnya Hansen and Chandni Pattni and Andrew Wong and Eric I Benchimol
DOI: 10.1093/jcag/gwab050
06/2022

Pediatric Endoscopy Quality Improvement Network Pediatric Endoscopy Reporting Elements: A Joint NASPGHAN/ESPGHAN Guideline
Journal of Pediatric Gastroenterology and Nutrition
Walsh, C.M. and Lightdale, J.R. and Fishman, D.S. and Furlano, R.I. and Mamula, P. and Gillett, P.M. and Narula, P. and Hojsak, I. and Oliva, S. and Homan, M. and Riley, M.R. and Huynh, H.Q. and Rosh, J.R. and Jacobson, K. and Tavares, M. and Leibowitz, I.H. and Utterson, E.C. and Croft, N.M. and Mack, D.R. and Brill, H. and Liu, Q.Y. and Bontems, P. and Lerner, D.G. and Amil-Dias, J. and Kramer, R.E. and Otley, A.R. and Ambartsumyan, L. and Connan, V. and McCreath, G.A. and Thomson, M.A.
DOI: 10.1097/MPG.0000000000003266
2022

Hospitalization with Clostridioides difficile in Pediatric Inflammatory Bowel Disease: A Population-Based Study
Journal of Pediatric Gastroenterology and Nutrition
Kuenzig, M.E. and Benchimol, E.I. and Bernstein, C.N. and Bitton, A. and Carroll, M.W. and Griffiths, A.M. and Kaplan, G.G. and Nguyen, G.C. and Otley, A.R. and Stukel, T.A. and Dummer, T.J.B. and El-Matary, W. and Jacobson, K. and Jones, J.L. and Lix, L.M. and Mack, D.R. and Murthy, S.K. and Pe{\~n}a-S{\'a}nchez, J.-N. and Targownik, L.E. and Fung, S.G. and Spruin, S. and Coward, S. and Cui, Y. and Filliter, C. and Nugent, Z. and Siddiq, S. and Singh, H.
DOI: 10.1097/MPG.0000000000003489
2022

Optimized Infliximab Induction Predicts Better Long-Term Clinical and Biomarker Outcomes Compared to Standard Induction Dosing
Journal of Pediatric Gastroenterology and Nutrition
Lawrence, S. and Faytrouni, F. and Harris, R.E. and Irvine, M. and Carrion, E. and Scott, G. and Clarke, B. and Garrick, V. and Curtis, L. and Gervais, L. and Tayler, R. and Riou, M. and Hansen, R. and Jacobson, K. and Russell, R.K.
DOI: 10.1097/MPG.0000000000003587
2022

Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation
Gastroenterology
Turpin, W. and Dong, M. and Sasson, G. and Raygoza Garay, J.A. and Espin-Garcia, O. and Lee, S.-H. and Neustaeter, A. and Smith, M.I. and Leibovitzh, H. and Guttman, D.S. and Goethel, A. and Griffiths, A.M. and Huynh, H.Q. and Dieleman, L.A. and Panaccione, R. and Steinhart, A.H. and Silverberg, M.S. and Aumais, G. and Jacobson, K. and Mack, D. and Murthy, S.K. and Marshall, J.K. and Bernstein, C.N. and Abreu, M.T. and Moayyedi, P. and Paterson, A.D. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and McGrath, J. and Otley, A. and Panancionne, R. and Baldassano, R. and Hedin, C. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Murthy, S. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C. and Xu, W.
DOI: 10.1053/j.gastro.2022.05.037
2022

Progression to Anti-TNF Treatment in Very Early Onset Inflammatory Bowel Disease Patients
Journal of Pediatric Gastroenterology and Nutrition
Eindor-Abarbanel, A. and Meleady, L. and Lawrence, S. and Hamilton, Z. and Krikler, G. and Lakhani, A. and Zhang, Q. and Jacobson, K.
DOI: 10.1097/MPG.0000000000003551
2022

Indirect and Out-of-Pocket Disease-associated Costs in Pediatric Inflammatory Bowel Disease: A Cross-sectional Analysis
Journal of Pediatric Gastroenterology and Nutrition
El-Matary, W. and Witt, J. and Bernstein, C.N. and Jacobson, K. and Mack, D. and Otley, A. and Walters, T.D. and Huynh, H.Q. and Debruyn, J. and Griffiths, A.M. and Benchimol, E.I.
DOI: 10.1097/MPG.0000000000003545
2022

Knowledge and practice of pediatricians regarding childhood constipation in the Arab world: results from a multicenter survey
BMC Pediatrics
Hasosah, M. and Haleem, A. and Jacobson, K. and Alshemmeri, B. and Alenazi, A. and Badei, A.A. and Massoud, P.
DOI: 10.1186/s12887-022-03536-3
2022

Dietary adherence to the Mediterranean diet pattern in a randomized clinical trial of patients with quiescent ulcerative colitis
Frontiers in Nutrition
Haskey, N. and Shim, R.C.K. and Davidson-Hunt, A. and Ye, J. and Singh, S. and Dieleman, L.A. and Jacobson, K. and Ghosh, S. and Gibson, D.L.
DOI: 10.3389/fnut.2022.1080156
2022

Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn's Disease
Gastroenterology
Leibovitzh, H. and Lee, S.-H. and Xue, M. and Raygoza Garay, J.A. and Hernandez-Rocha, C. and Madsen, K.L. and Meddings, J.B. and Guttman, D.S. and Espin-Garcia, O. and Smith, M.I. and Goethel, A. and Griffiths, A.M. and Moayyedi, P. and Steinhart, A.H. and Panaccione, R. and Huynh, H.Q. and Jacobson, K. and Aumais, G. and Mack, D.R. and Abreu, M.T. and Bernstein, C.N. and Marshall, J.K. and Turner, D. and Xu, W. and Turpin, W. and Croitoru, K.
DOI: 10.1053/j.gastro.2022.07.004
2022

The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study
Journal of Crohn's and Colitis
Dhaliwal, J. and Carroll, M.W. and Debruyn, J.C. and Ricciuto, A. and Benchimol, E.I. and Lawrence, S. and Sherlock, M. and El-Matary, W. and Brill, H. and Church, P. and Wine, E. and Carman, N. and Muise, A. and Huynh, H. and Mack, D.R. and Walters, T.D. and Griffiths, A.M. and Jacobson, K.
DOI: 10.1093/ecco-jcc/jjab143
2022

Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopy Facilities: A Joint NASPGHAN/ESPGHAN Guideline
Journal of Pediatric Gastroenterology and Nutrition
Lightdale, J.R. and Walsh, C.M. and Narula, P. and Utterson, E.C. and Tavares, M. and Rosh, J.R. and Riley, M.R. and Oliva, S. and Mamula, P. and Mack, D.R. and Liu, Q.Y. and Lerner, D.G. and Leibowitz, I.H. and Jacobson, K. and Huynh, H.Q. and Homan, M. and Hojsak, I. and Gillett, P.M. and Furlano, R.I. and Fishman, D.S. and Croft, N.M. and Brill, H. and Bontems, P. and Amil-Dias, J. and Kramer, R.E. and Ambartsumyan, L. and Otley, A.R. and McCreath, G.A. and Connan, V. and Thomson, M.A.
DOI: 10.1097/MPG.0000000000003263
2022

Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopists and Endoscopists in Training: A Joint NASPGHAN/ESPGHAN Guideline
Journal of Pediatric Gastroenterology and Nutrition
Walsh, C.M. and Lightdale, J.R. and Leibowitz, I.H. and Lerner, D.G. and Liu, Q.Y. and Mack, D.R. and Mamula, P. and Narula, P. and Oliva, S. and Riley, M.R. and Rosh, J.R. and Tavares, M. and Utterson, E.C. and Amil-Dias, J. and Bontems, P. and Brill, H. and Croft, N.M. and Fishman, D.S. and Furlano, R.I. and Gillett, P.M. and Hojsak, I. and Homan, M. and Huynh, H.Q. and Jacobson, K. and Ambartsumyan, L. and Otley, A.R. and Kramer, R.E. and McCreath, G.A. and Connan, V. and Thomson, M.A.
DOI: 10.1097/MPG.0000000000003265
2022

Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopic Procedures: A Joint NASPGHAN/ESPGHAN Guideline
Journal of Pediatric Gastroenterology and Nutrition
Lightdale, J.R. and Walsh, C.M. and Oliva, S. and Jacobson, K. and Huynh, H.Q. and Homan, M. and Hojsak, I. and Gillett, P.M. and Furlano, R.I. and Fishman, D.S. and Croft, N.M. and Brill, H. and Bontems, P. and Amil-Dias, J. and Utterson, E.C. and Tavares, M. and Rosh, J.R. and Riley, M.R. and Narula, P. and Mamula, P. and Mack, D.R. and Liu, Q.Y. and Lerner, D.G. and Leibowitz, I.H. and Otley, A.R. and Kramer, R.E. and Ambartsumyan, L. and Connan, V. and McCreath, G.A. and Thomson, M.A.
DOI: 10.1097/MPG.0000000000003264
2022

Overview of the Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopy: A Joint NASPGHAN/ESPGHAN Guideline
Journal of Pediatric Gastroenterology and Nutrition
Walsh, C.M. and Lightdale, J.R. and Mack, D.R. and Amil-Dias, J. and Bontems, P. and Brill, H. and Croft, N.M. and Fishman, D.S. and Furlano, R.I. and Gillett, P.M. and Hojsak, I. and Homan, M. and Huynh, H.Q. and Jacobson, K. and Leibowitz, I.H. and Lerner, D.G. and Liu, Q.Y. and Mamula, P. and Narula, P. and Oliva, S. and Riley, M.R. and Rosh, J.R. and Tavares, M. and Utterson, E.C. and Ambartsumyan, L. and Otley, A.R. and Kramer, R.E. and Connan, V. and McCreath, G.A. and Thomson, M.A.
DOI: 10.1097/MPG.0000000000003262
2022

Pediatric Quality of Life InventoryTM version 4.0 short form generic core scale across pediatric populations review data
Data in Brief
Matthew Smyth and Kevan Jacobson
DOI: 10.1016/j.dib.2021.107599
12/2021

Therapeutic Advances in Gut Microbiome Modulation in Patients with Inflammatory Bowel Disease from Pediatrics to Adulthood
International Journal of Molecular Sciences
Adi Eindor- Abarbanel and Genelle R. Healey and Kevan Jacobson
DOI: 10.3390/ijms222212506
11/2021

Diagnostic Delay Is Associated With Complicated Disease and Growth Impairment in Paediatric Crohn’s Disease
Journal of Crohn's and Colitis
Amanda Ricciuto and David R Mack and Hien Q Huynh and Kevan Jacobson and Anthony R Otley and Jennifer deBruyn and Wael El-Matary and Colette Deslandres and Mary E Sherlock and Jeffrey N Critch and Kevin Bax and Prevost Jantchou and Ernest G Seidman and Nicholas Carman and Mohsin Rashid and Aleixo Muise and Eytan Wine and Matthew W Carroll and Sally Lawrence and Johan Van Limbergen and Eric I Benchimol and Thomas D Walters and Anne M Griffiths and Peter C Church
DOI: 10.1093/ecco-jcc/jjaa197
03/2021

Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis
International Journal of Infectious Diseases
Boyan K. Tsankov and Joannie M. Allaire and Michael A. Irvine and Alison A. Lopez and Laura J. Sauvé and Bruce A. Vallance and Kevan Jacobson
DOI: 10.1016/j.ijid.2020.11.163
02/2021

Comparing Health Administrative and Clinical Registry Data: Trends in Incidence and Prevalence of Pediatric Inflammatory Bowel Disease in British Columbia
Clinical Epidemiology
Justin M Chan and Matthew W Carroll and Matthew Smyth and Zachary Hamilton and Dewey Evans and Kimberlyn McGrail and Eric I Benchimol and Kevan Jacobson
DOI: 10.2147/CLEP.S292546
02/2021

AN INULIN-TYPE FRUCTAN ENRICHED EXCLUSIVE ENTERAL NUTRITION FORMULA SUPPRESSES COLITIS THROUGH GUT MICROBIOME MODULATION AND PROMOTING EXPANSION OF ANTI-INFLAMMATORY T CELL SUBSETS
Genelle R. Healey and Kevin Tsai and Daniel J. Lisko and Laura Cook and Bruce A. Vallance and Kevan Jacobson
DOI: 10.1101/2021.02.02.429403
02/2021

Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk
Gastroenterology
Lee, S.-H. and Turpin, W. and Espin-Garcia, O. and Raygoza Garay, J.A. and Smith, M.I. and Leibovitzh, H. and Goethel, A. and Turner, D. and Mack, D. and Deslandres, C. and Cino, M. and Aumais, G. and Panaccione, R. and Jacobson, K. and Bitton, A. and Steinhart, A.H. and Huynh, H.Q. and Princen, F. and Moayyedi, P. and Griffiths, A.M. and Silverberg, M.S. and Paterson, A.D. and Xu, W. and Croitoru, K.
DOI: 10.1053/j.gastro.2021.07.009
2021

Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis
Cellular and Molecular Gastroenterology and Hepatology
Genelle R. Lunken and Kevin Tsai and Alana Schick and Daniel J. Lisko and Laura Cook and Bruce A. Vallance and Kevan Jacobson
DOI: 10.1016/j.jcmgh.2021.06.011
2021

Harnessing Big Data to Optimize an Algorithm for Rapid Diagnosis of Pulmonary Tuberculosis in a Real-World Setting
Frontiers in Cellular and Infection Microbiology
Peng, J. and Song, J. and Wang, F. and Zuo, P. and Lu, Y. and Liu, W. and Tian, L. and Chen, Z. and Zhu, Y. and Wang, X. and Shen, N. and Wang, X. and Wu, S. and Yu, Q. and Vallance, B.A. and Jacobson, K. and Sun, Z. and Yu, H.B.
DOI: 10.3389/fcimb.2021.650163
2021

Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients
Frontiers in Physiology
Power, N. and Turpin, W. and Espin-Garcia, O. and Smith, M.I. and Croitoru, K. and Abreu, M. and Beck, P. and Bernstein, C. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R.
DOI: 10.3389/fphys.2021.645303
2021

Early Serum Infliximab Levels in Pediatric Ulcerative Colitis
Frontiers in Pediatrics
deBruyn, J.C.C. and Jacobson, K. and El-Matary, W. and Wine, E. and Carroll, M.W. and Goedhart, C. and Panaccione, R. and Wrobel, I.T. and Huynh, H.Q.
DOI: 10.3389/fped.2021.668978
2021

Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells
Proceedings of the National Academy of Sciences of the United States of America
Yu, H.B. and Yang, H. and Allaire, J.M. and Ma, C. and Graef, F.A. and Mortha, A. and Liang, Q. and Bosman, E.S. and Reid, G.S. and Waschek, J.A. and Osborne, L.C. and Sokol, H. and Vallance, B.A. and Jacobson, K.
DOI: 10.1073/pnas.2106634118
2021

Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
Gastroenterology
Galipeau, H.J. and Caminero, A. and Turpin, W. and Bermudez-Brito, M. and Santiago, A. and Libertucci, J. and Constante, M. and Raygoza Garay, J.A. and Rueda, G. and Armstrong, S. and Clarizio, A. and Smith, M.I. and Surette, M.G. and Bercik, P. and Beck, P. and Bernstein, C. and Croitoru, K. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Verdu, E.F.
DOI: 10.1053/j.gastro.2020.12.004
2021

E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis
Nature Cell Biology
Patankar, J.V. and Müller, T.M. and Kantham, S. and Acera, M.G. and Mascia, F. and Scheibe, K. and Mahapatro, M. and Heichler, C. and Yu, Y. and Li, W. and Ruder, B. and Günther, C. and Leppkes, M. and Mathew, M.J. and Wirtz, S. and Neufert, C. and Kühl, A.A. and Paquette, J. and Jacobson, K. and Atreya, R. and Zundler, S. and Neurath, M.F. and Young, R.N. and Becker, C.
DOI: 10.1038/s41556-021-00708-8
2021

Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection
PLoS Pathogens
Graef, F.A. and Celiberto, L.S. and Allaire, J.M. and Kuan, M.T.Y. and Bosman, E.S. and Crowley, S.M. and Yang, H. and Chan, J.H. and Stahl, M. and Yu, H. and Quin, C. and Gibson, D.L. and Verdu, E.F. and Jacobson, K. and Vallance, B.A.
DOI: 10.1371/journal.ppat.1009719
2021

Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids
Scientific Reports
Allaire, J.M. and Poon, A. and Crowley, S.M. and Han, X. and Sharafian, Z. and Moore, N. and Stahl, M. and Bressler, B. and Lavoie, P.M. and Jacobson, K. and Li, X. and Vallance, B.A.
DOI: 10.1038/s41598-021-87592-2
2021

Inflammatory Bowel Disease Increases the Risk of Venous Thromboembolism in Children: A Population-Based Matched Cohort Study
Journal of Crohn's & colitis
Kuenzig, M.E. and Bitton, A. and Carroll, M.W. and Kaplan, G.G. and Otley, A.R. and Singh, H. and Nguyen, G.C. and Griffiths, A.M. and Stukel, T.A. and Targownik, L.E. and Jones, J.L. and Murthy, S.K. and McCurdy, J.D. and Bernstein, C.N. and Lix, L.M. and Peña-Sánchez, J.N. and Mack, D.R. and Jacobson, K. and El-Matary, W. and Dummer, T.J.B. and Fung, S.G. and Spruin, S. and Nugent, Z. and Tanyingoh, D. and Cui, Y. and Filliter, C. and Coward, S. and Siddiq, S. and Benchimol, E.I.
DOI: 10.1093/ecco-jcc/jjab113
2021

Cross-Sectional Analysis of Quality of Life in Pediatric Patients with Inflammatory Bowel Disease in British Columbia, Canada
Journal of Pediatrics
Smyth, M. and Chan, J. and Evans, K. and Penner, C. and Lakhani, A. and Newlove, T. and Jacobson, K.
DOI: 10.1016/j.jpeds.2021.07.036
2021

Interleukin-37 Regulates Innate Immune Signaling in Human and Mouse Colonic Organoids
Allaire J and Poon A and Crowley S and Han X and Moore N and Stahl M and Bressler B and Jacobson K and Li X and Vallance B
DOI: 10.21203/rs.3.rs-126899/v1
12/2020

Fiber and Prebiotic Interventions in Pediatric Inflammatory Bowel Disease: What Role Does the Gut Microbiome Play?
Nutrients
Genelle R. Healey and Larissa S. Celiberto and Soo Min Lee and Kevan Jacobson
DOI: 10.3390/nu12103204
10/2020

Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2.
Frontiers in medicine
Peng J and Lu Y and Song J and Vallance BA and Jacobson K and Yu HB and Sun Z
DOI: 10.3389/fmed.2020.549860
PubMed: 33043036
09/2020

Increased Intestinal Permeability is Associated with Later Development of Crohn's Disease.
Gastroenterology
Turpin W and Lee SH and Raygoza Garay JA and Madsen KL and Meddings JB and Bedrani L and Power N and Espin-Garcia O and Xu W and Smith MI and Griffiths AM and Moayyedi P and Turner D and CCC GEM Project Research Consortium
DOI: 10.1053/j.gastro.2020.08.005
PubMed: 32791132
08/2020

Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation
Journal of Crohn's and Colitis
William D Rees and Martin Stahl and Kevan Jacobson and Brian Bressler and Laura M Sly and Bruce A Vallance and Theodore S Steiner
DOI: 10.1093/ecco-jcc/jjz194
07/2020

Discontinuation of Immunosuppressive Medications in Children with Inflammatory Bowel Disease on Combination Therapy.
Journal of pediatric gastroenterology and nutrition
El-Matary W and Carroll MW and deBruyn JC and Huynh H and Wine E and Lawrence S and Chandrakumar A and Morel T and Jacobson K
DOI: 10.1097/mpg.0000000000002857
PubMed: 32740529
07/2020

High body mass index is not associated with increased treatment failure in infliximab treated pediatric patients with inflammatory bowel disease
JGH Open
Isaac Rodin and Justin Chan and Laura Meleady and Clare Hii and Sally Lawrence and Kevan Jacobson
DOI: 10.1002/jgh3.12277
06/2020

Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network
Journal of Crohn's and Colitis
J Dhaliwal and T D Walters and D R Mack and H Q Huynh and K Jacobson and A R Otley and J Debruyn and W El-Matary and C Deslandres and M E Sherlock and J N Critch and K Bax and E Seidman and P Jantchou and A Ricciuto and M Rashid and A M Muise and E Wine and M Carroll and S Lawrence and J Van Limbergen and E I Benchimol and P Church and A M Griffiths
DOI: 10.1093/ecco-jcc/jjz106
05/2020

398 THE GEM PROJECT: IDENTIFICATION OF A SERUM PROTEOMIC SIGNATURE ASSOCIATED WITH RISK OF FUTURE CROHN'S DISEASE ONSET IN A COHORT OF HEALTHY AT-RISK INDIVIDUALS
Gastroenterology
Juan Antonio Raygoza Garay and Williams Turpin and Michelle I. Smith and Ashleigh Goethel and Hien Q. Huynh and Anne M. Griffiths and Dan Turner and A. Hillary Steinhart and Ernest G. Seidman and David R. Mack and Kevan Jacobson and Mark Ropeleski and Maria Cino and Guy L. Aumais and Remo Panaccione and Colette Deslandres and Iwona Wrobel and Jonas Halfvarson and Kenneth Croitoru
DOI: 10.1016/s0016-5085(20)30864-7
05/2020

135 THE GEM PROJECT: DIETARY PATTERNS ARE ASSOCIATED WITH MICROBIOME COMPOSITION AND INTESTINAL INFLAMMATION IN HEALHY FIRST-DEGREE RELATIVES OF CROHN'S DISEASE PATIENTS
Gastroenterology
Gila Sasson and Williams Turpin and Juan Antonio Raygoza Garay and Namita Power and Michelle I. Smith and David S. Guttman and Sun-Ho Lee and Anne M. Griffiths and Hien Q. Huynh and Levinus A. Dieleman and Remo Panaccione and A. Hillary Steinhart and Mark S. Silverberg and Guy L. Aumais and Ernest G. Seidman and Kevan Jacobson and David R. Mack and Sanjay K. Murthy and John K. Marshall and Maria T. Abreu and Paul Moayyedi and Kenneth Croitoru
DOI: 10.1016/s0016-5085(20)30749-6
05/2020

Su1980 THE GEM PROJECT: IMPAIRED GUT BARRIER FUNCTION IS ASSOCIATED WITH FUTURE DEVELOPMENT OF CROHN'S DISEASE EVEN IN THE PRESENCE OR ABSCENCE OF PRECLINICAL INFLAMMATION IN ASYMPTOMATIC FIRST-DEGREE RELATIVES OF CROHN'S PATIENTS
Gastroenterology
Sun-Ho Lee and Williams Turpin and Juan Antonio Raygoza Garay and Karen Madsen and Jon Meddings and Larbi Bedrani and Namita Power and Wei Xu and Michelle I. Smith and Anne M. Griffiths and Paul Moayyedi and Dan Turner and Ernest G. Seidman and A. Hillary Steinhart and John K. Marshall and Kevan Jacobson and David R. Mack and Hien Q. Huynh and Charles N. Bernstein and Andrew Paterson and Kenneth Croitoru
DOI: 10.1016/s0016-5085(20)32506-3
05/2020

Mo1132 TLR4 SIGNALING PROTECTS THE INTESTINAL EPITHELIUM FROM TNFa DRIVEN CELL DEATH AND BARRIER DISRUPTION DURING SALMONELLA TYPHIMURIUM INDUCED COLITIS
Gastroenterology
Qin Yu and Kevin Tsai and Shauna M. Crowley and Caixia Ma and Dean Tian and Kevan Jacobson and Bruce Vallance
DOI: 10.1016/s0016-5085(20)32673-1
05/2020

A26 PEDIATRIC-ONSET INFLAMMATORY BOWEL DISEASE INCREASES THE RISK OF VENOUS THROMBOEMBOLISM: A CANGIEC POPULATION-BASED STUDY
Journal of the Canadian Association of Gastroenterology
E Kuenzig and H Singh and A Bitton and G G Kaplan and M W Carroll and A Otley and T A Stukel and S Spruin and Z Nugent and D Tanyingoh and Y Cui and C Filliter and S Coward and A Griffiths and D Mack and K Jacobson and G C Nguyen and L Targownik and W El-Matary and E I Benchimol
DOI: 10.1093/jcag/gwz047.025
02/2020

A202 DYSREGULATED ENDOPLASMIC RETICULUM STRESS PATHWAYS IN COLON-DERIVED ENTEROIDS FROM INFLAMMATORY BOWEL DISEASE PATIENTS DRIVE DC MATURATION LEADING TO A PRO-INFLAMMATORY PHENOTYPE
Journal of the Canadian Association of Gastroenterology
W D Rees and M Stahl and K Jacobson and B Bressler and L M Sly and B Vallance and T Steiner
DOI: 10.1093/jcag/gwz047.201
02/2020

A65 VARIATION IN THE CARE OF CHILDREN WITH INFLAMMATORY BOWEL DISEASE: A CANGIEC POPULATION-BASED STUDY
Journal of the Canadian Association of Gastroenterology
E Kuenzig and H Singh and A Bitton and G G Kaplan and M W Carroll and A Otley and T A Stukel and S Spruin and A Griffiths and D Mack and K Jacobson and G C Nguyen and L Targownik and W El-Matary and S Nasiri and E I Benchimol
DOI: 10.1093/jcag/gwz047.064
02/2020

A171 MAGNETIC RESONANCE IMAGING IN CHILDREN WITH EARLY ONSET INFLAMMATORY BOWEL DISEASE- A RETROSPECTIVE COHORT STUDY
Journal of the Canadian Association of Gastroenterology
A Eindor and L Meleady and A Lakhani and S Lawrence and G Krikler and Z Hamilton and K Jacobson
DOI: 10.1093/jcag/gwz047.170
02/2020

P552 Withdrawal of immunomodulator medications (IM) in children with inflammatory bowel disease on combination therapy of IM and biologics
Journal of Crohn's and Colitis
A Chandrakumar and M Carroll and J deBruyn and K Jacobson and H Huynh and E Wine and S Lawrence and W El-Matary
DOI: 10.1093/ecco-jcc/jjz203.680
01/2020

P587 Adalimumab in pediatric Crohn’s disease: A long-term multi-centre real-world experience
Journal of Crohn's and Colitis
S Lawrence and H Huynh and W El-Matary and J DeBruyn and M Carroll and E Wine and J Chan and K Jacobson
DOI: 10.1093/ecco-jcc/jjz203.715
01/2020

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts
Gut Microbes
Yang, H. and Mirsepasi-Lauridsen, H.C. and Struve, C. and Allaire, J.M. and Sivignon, A. and Vogl, W. and Bosman, E.S. and Ma, C. and Fotovati, A. and Reid, G.S. and Li, X. and Petersen, A.M. and Gouin, S.G. and Barnich, N. and Jacobson, K. and Yu, H.B. and Krogfelt, K.A. and Vallance, B.A.
DOI: 10.1080/19490976.2020.1847976
2020

A dose-response and meta-analysis of phytosterols consumption on liver enzymes: Evidence from randomized clinical trials
Nutrition and Food Science
Tajik, S. and Jacobson, K. and Talaei, S. and Kord-Varkaneh, H. and Noormohammadi, Z. and Salehi-Sahlabadi, A. and Pezeshki, M. and Rahmani, J. and Hekmatdoost, A.
DOI: 10.1108/NFS-06-2019-0182
2020

In Reply to (Meta-analysis on obesity and risk of inflammatory bowel disease: re-analysis is needed)
Obesity Reviews
Rahmani, J. and Kord Varkaneh, H. and Hekmatdoost, A. and Thompson, J. and Clark, C. and Salehisahlabadi, A. and Day, A.S. and Jacobson, K.
DOI: 10.1111/obr.12956
2020

Discontinuation of Immunosuppressive Medications in Children with Inflammatory Bowel Disease on Combination Therapy
Journal of Pediatric Gastroenterology and Nutrition
DOI: 10.1097/MPG.0000000000002857
2020

Enteroids derived from inflammatory bowel disease patients display dysregulated endoplasmic reticulum stress pathways, leading to differential inflammatory responses and dendritic cell maturation
Journal of Crohn's and Colitis
Rees, W.D. and Stahl, M. and Jacobson, K. and Bressler, B. and Sly, L.M. and Vallance, B.A. and Steiner, T.S.
DOI: 10.1093/ECCO-JCC/JJZ194
2020

Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn’s disease subjects
BMC Medical Genetics
Turpin, W. and Bedrani, L. and Espin-Garcia, O. and Xu, W. and Silverberg, M.S. and Smith, M.I. and Garay, J.A.R. and Lee, S.-H. and Guttman, D.S. and Griffiths, A. and Moayyedi, P. and Panaccione, R. and Huynh, H. and Steinhart, H.A. and Aumais, G. and Dieleman, L.A. and Turner, D. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Feagan, B. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Seidman, E. and Silverberg, M. and Stadnyk, A. and Steinhart, A.H. and Surette, M. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Baldassano, R. and Griffiths, A.M. and Hedin, C. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Murthy, S. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Ropeleski, M. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C. and Snapper, S. and Paterson, A.D. and Croitoru, K.
DOI: 10.1186/s12881-020-01115-w
2020

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells
Gastroenterology
Laura Cook and Martin Stahl and Xiao Han and Aisha Nazli and Katherine N. MacDonald and May Q. Wong and Kevin Tsai and Sara Dizzell and Kevan Jacobson and Brian Bressler and Charu Kaushic and Bruce A. Vallance and Theodore S. Steiner and Megan K. Levings
DOI: 10.1053/j.gastro.2019.09.002
12/2019

Capsule Endoscopy Complements Magnetic Resonance Enterography and Endoscopy in Evaluating Small Bowel Crohn's Disease.
Journal of the Canadian Association of Gastroenterology
Prichard DO and Hamilton Z and Savage T and Smyth M and Penner C and Lakhani A and Carroll MW and Al Sarkhy A and Lemberg DA and Enns R and Jamieson D and Jacobson K
DOI: 10.1093/jcag/gwz028
PubMed: 33241181
09/2019

Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data
Gastroenterology
Stephanie Coward and Fiona Clement and Eric I. Benchimol and Charles N. Bernstein and J. Antonio Avina-Zubieta and Alain Bitton and Mathew W. Carroll and Glen Hazlewood and Kevan Jacobson and Susan Jelinski and Rob Deardon and Jennifer L. Jones and M. Ellen Kuenzig and Desmond Leddin and Kerry A. McBrien and Sanjay K. Murthy and Geoffrey C. Nguyen and Anthony R. Otley and Remo Panaccione and Ali Rezaie and Greg Rosenfeld and Juan Nicolás Peña-Sánchez and Harminder Singh and Laura E. Targownik and Gilaad G. Kaplan
DOI: 10.1053/j.gastro.2019.01.002
04/2019

Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients
World Journal of Gastroenterology
Foster, A.J. and Smyth, M. and Lakhani, A. and Jung, B. and Brant, R.F. and Jacobson, K.
DOI: 10.3748/wjg.v25.i10.1266
2019

Higher postinduction infliximab serum trough levels are associated with healing of fistulizing perianal Crohn's disease in children
Inflammatory Bowel Diseases
El-Matary, W. and Walters, T.D. and Huynh, H.Q. and Debruyn, J. and MacK, D.R. and Jacobson, K. and Sherlock, M.E. and Church, P. and Wine, E. and Carroll, M.W. and Benchimol, E.I. and Lawrence, S. and Griffiths, A.M.
DOI: 10.1093/ibd/izy217
2019

Clinical disease activity and endoscopic severity correlate poorly in children newly diagnosed with Crohn's disease
Gastrointestinal Endoscopy
Carman, N. and Tomalty, D. and Church, P.C. and Mack, D.R. and Benchimol, E.I. and Otley, A.R. and Jacobson, K. and Huynh, H.Q. and DeBruyn, J.C. and El-Matary, W. and Sherlock, M. and Van Limbergen, J. and Griffiths, A.M. and Walters, T.D.
DOI: 10.1016/j.gie.2018.09.025
2019

Body mass index and risk of inflammatory bowel disease: A systematic review and dose-response meta-analysis of cohort studies of over a million participants
Obesity Reviews
Rahmani, J. and Kord-Varkaneh, H. and Hekmatdoost, A. and Thompson, J. and Clark, C. and Salehisahlabadi, A. and Day, A.S. and Jacobson, K.
DOI: 10.1111/obr.12875
2019

Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease
Inflammatory Bowel Diseases
Turpin, W. and Espin-Garcia, O. and Bedrani, L. and Madsen, K. and Meddings, J.B. and Raygoza Garay, J.A. and Silverberg, M.S. and Smith, M.I. and Griffiths, A.M. and Moayyedi, P. and Marshall, J.K. and Mack, D. and Seidman, E.G. and Ropeleski, M. and Feagan, B.G. and Jacobson, K. and Turner, D. and Walters, T. and Paterson, A.D. and Xu, W. and Croitoru, K.
DOI: 10.1093/ibd/izz116
2019

Management of Paediatric Patients with Medically Refractory Crohn's Disease Using Ustekinumab: A Multi-Centred Cohort Study
Journal of Crohn's and Colitis
Chavannes, M. and Martinez-Vinson, C. and Hart, L. and Kaniki, N. and Chao, C.-Y. and Lawrence, S. and Jacobson, K. and Hugot, J.-P. and Viala, J. and Deslandres, C. and Jantchou, P. and Seidman, E.G.
DOI: 10.1093/ecco-jcc/jjy206
2019

Rural and urban disparities in the care of Canadian patients with inflammatory bowel disease: a population-based study
Clinical Epidemiology
DOI: 10.2147/clep.s178056
11/2018

The Muc2 mucin coats murine Paneth cell granules and facilitates their content release and dispersion
American Journal of Physiology-Gastrointestinal and Liver Physiology
Martin Stahl and Sarah Tremblay and Marinieve Montero and Wayne Vogl and Lijun Xia and Kevan Jacobson and Alfredo Menendez and Bruce A. Vallance
DOI: 10.1152/ajpgi.00264.2017
08/2018

Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome
Immunology
Larissa S. Celiberto and Franziska A. Graef and Genelle R. Healey and Else S. Bosman and Kevan Jacobson and Laura M. Sly and Bruce A. Vallance
DOI: 10.1111/imm.12939
05/2018

Dietary patterns and risk of ulcerative colitis: a case-control study
Journal of Human Nutrition and Dietetics
S. Rashvand and M. Behrooz and M. Samsamikor and K. Jacobson and A. Hekmatdoost
DOI: 10.1111/jhn.12544
02/2018

Rural and urban disparities in the care of canadian patients with inflammatory bowel disease: A population-based study
Clinical Epidemiology
Benchimol, E.I. and Kuenzig, M.E. and Bernstein, C.N. and Nguyen, G.C. and Guttmann, A. and Jones, J.L. and Potter, B.K. and Targownik, L.E. and Catley, C.A. and Nugent, Z.J. and Tanyingoh, D. and Mojaverian, N. and Underwood, F.E. and Siddiq, S. and Otley, A.R. and Bitton, A. and Carroll, M.W. and Debruyn, J.C. and Dummer, T.J.B. and El-Matary, W. and Griffiths, A.M. and Jacobson, K. and Leddin, D. and Lix, L.M. and Mack, D.R. and Murthy, S.K. and Peña-Sánchez, J.N. and Singh, H. and Kaplan, G.G.
DOI: 10.2147/CLEP.S178056
2018

Long-term Outcomes of Infliximab Use for Pediatric Crohn Disease: A Canadian Multicenter Clinical Practice Experience
Journal of Pediatric Gastroenterology and Nutrition
DeBruyn, J.C. and Jacobson, K. and El-Matary, W. and Carroll, M. and Wine, E. and Wrobel, I. and Van Woudenberg, M. and Huynh, H.Q.
DOI: 10.1097/MPG.0000000000001672
2018

Frontline defenders: Goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease
American Journal of Physiology - Gastrointestinal and Liver Physiology
Allaire, J.M. and Morampudi, V. and Crowley, S.M. and Stahl, M. and Yu, H. and Bhullar, K. and Knodler, L.A. and Bressler, B. and Jacobson, K. and Vallance, B.A.
DOI: 10.1152/ajpgi.00181.2017
2018

Concomitant Therapy with Immunomodulator Enhances Infliximab Durability in Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Julianna Cheng and Zachary Hamilton and Matthew Smyth and Collin Barker and David Israel and Kevan Jacobson
DOI: 10.1097/mib.0000000000001212
10/2017

Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome.
Applied and environmental microbiology
Peixoto RJM and Alves ES and Wang M and Ferreira RBR and Granato A and Han J and Gill H and Jacobson K and Lobo LA and Domingues RMCP and Borchers CH and Davies JE and Finlay BB and Antunes LCM
DOI: 10.1128/aem.01148-17
PubMed: 28754707
07/2017

Rural and Urban Residence During Early Life is Associated with Risk of Inflammatory Bowel Disease: A Population-Based Inception and Birth Cohort Study
The American Journal of Gastroenterology
DOI: 10.1038/ajg.2017.208
PubMed: 28741616
07/2017

Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.
The American journal of gastroenterology
Benchimol EI and Bernstein CN and Bitton A and Carroll MW and Singh H and Otley AR and Vutcovici M and El-Matary W and Nguyen GC and Griffiths AM and Mack DR and Jacobson K and Kaplan GG
DOI: 10.1038/ajg.2017.97
PubMed: 28417994
07/2017

Long-term Outcomes of Infliximab use for Pediatric Crohn's disease
Journal of Pediatric Gastroenterology and Nutrition
Jennifer C. deBruyn and Kevan Jacobson and Wael El-Matary and Matthew Carroll and Eytan Wine and Iwona Wrobel and Mariel Van Woudenberg and Hien Q. Huynh
DOI: 10.1097/mpg.0000000000001672
06/2017

Ulcerative Colitis-Associated Escherichia Coli Colonize the Intestinal Mucosa of Susceptible Host and Promote Colitis via Hemolysin Production
Gastroenterology
Hengameh Chloé Mirsepasi-Lauridsen and Hyungjun Yang and Else Bosman and Carsten Struve and Hongbing Yu and Xiujuan Wu and Caixia Ma and Abbas Fotovati and Andreas M. Petersen and Kevan Jacobson and Karen A. Krogfelt and Bruce Vallance
DOI: 10.1016/s0016-5085(17)32838-x
04/2017

Capsule Endoscopy Complements Magnetic Resonance Enterography and Ileo-Colonoscopy in the Evaluation of Suspected Small Bowel Crohn’s Disease in Pediatric Patients
Gastroenterology
David O. Prichard and Zachary Hamilton and Thomas Savage and Matthew Smyth and Carlie Penner and Alam Lakhani and Matthew Carroll and Ahmed A. Alsarkhy and Daniel Lemberg and Robert A. Enns and Robert J. Prosser and Daniel Jamieson and Kevan Jacobson
DOI: 10.1016/s0016-5085(17)32196-0
04/2017

The Prevalence and Predictors of Anti-TNF Failure in a Population based Sample of Persons with IBD
Gastroenterology
Laura E. Targownik and Charles N. Bernstein and Harminder Singh and Aruni Tennakoon and Stella leung and Zoann Nugent and Lisa Lix and Kevan Jacobson and Juan-Nicolas Pena-Sanchez and Gilaad Kaplan
DOI: 10.1016/s0016-5085(17)31463-4
04/2017

Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development.
Scientific reports
Bhinder G and Allaire JM and Garcia C and Lau JT and Chan JM and Ryz NR and Bosman ES and Graef FA and Crowley SM and Celiberto LS and Berkmann JC and Dyer RA and Jacobson K and Vallance BA
DOI: 10.1038/srep45274
PubMed: 28349941
03/2017

Tricellular Tight Junction Protein Tricellulin Is Targeted by the Enteropathogenic Escherichia coli Effector EspG1, Leading to Epithelial Barrier Disruption.
Infection and immunity
Morampudi V and Graef FA and Stahl M and Dalwadi U and Conlin VS and Huang T and Vallance BA and Yu HB and Jacobson K
DOI: 10.1128/iai.00700-16
PubMed: 27795363
01/2017

Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease
World Journal of Gastroenterology
Nancy Fu and Kevan Jacobson and Andrew Round and Kathi Evans and Hong Qian and Brian Bressler
DOI: 10.3748/wjg.v23.i29.5405
2017

Allied Health Professional Support in Pediatric Inflammatory Bowel Disease: A Survey from the Canadian Children Inflammatory Bowel Disease Network - A Joint Partnership of CIHR and the CH.I.L.D. Foundation
Canadian Journal of Gastroenterology and Hepatology
El-Matary, W. and Benchimol, E.I. and MacK, D. and Huynh, H.Q. and Critch, J. and Otley, A. and Deslandres, C. and Jacobson, K. and Debruyn, J. and Carroll, M.W. and Wine, E. and Van Limbergen, J. and Sherlock, M. and Bax, K. and Lawrence, S. and Seidman, E. and Issenman, R. and Walters, T.D. and Church, P. and Griffiths, A.M.
DOI: 10.1155/2017/3676474
2017

Tricellular tight junction protein tricellulin is targeted by the enteropathogenic Escherichia coli effector EspG1, leading to epithelial barrier disruption
Infection and Immunity
Morampudi, V. and Graef, F.A. and Stahl, M. and Dalwadi, U. and Conlin, V.S. and Huang, T. and Vallance, B.A. and Yu, H.B. and Jacobson, K.
DOI: 10.1128/IAI.00700-16
2017

Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome
Applied and Environmental Microbiology
Peixoto, R.J.M. and Alves, E.S. and Wang, M. and Ferreira, R.B.R. and Granato, A. and Han, J. and Gill, H. and Jacobson, K. and Lobo, L.A. and Domingues, R.M.C.P. and Borchers, C.H. and Davies, J.E. and Brett Finlay, B. and Antunes, L.C.M.
DOI: 10.1128/AEM.01148-17
2017

Concomitant Therapy with Immunomodulator Enhances Infliximab Durability in Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Cheng, J. and Hamilton, Z. and Smyth, M. and Barker, C. and Israel, D. and Jacobson, K.
DOI: 10.1097/MIB.0000000000001212
2017

Pneumocystis jirovecii pneumonia in pediatric inflammatory bowel disease: A case report and literature review
Frontiers in Pediatrics
Lawrence, S.J. and Sadarangani, M. and Jacobson, K.
DOI: 10.3389/fped.2017.00161
2017

Association of host genome with intestinal microbial composition in a large healthy cohort
Nature Genetics
Williams Turpin and GEM Project Research Consortium and Osvaldo Espin-Garcia and Wei Xu and Mark S Silverberg and David Kevans and Michelle I Smith and David S Guttman and Anne Griffiths and Remo Panaccione and Anthony Otley and Lizhen Xu and Konstantin Shestopaloff and Gabriel Moreno-Hagelsieb and Andrew D Paterson and Kenneth Croitoru
DOI: 10.1038/ng.3693
10/2016

The goblet cell-derived mediator RELM-ß drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.
Mucosal Immunology
Morampudi V and Dalwadi U and Bhinder G and Sham HP and Gill SK and Chan J and Bergstrom KS and Huang T and Ma C and Jacobson K and Gibson DL and Vallance BA
DOI: 10.1038/mi.2015.140
PubMed: 26813339
09/2016

Pediatric Inflammatory Bowel Disease Among South Asians Living in British Columbia, Canada
Inflammatory Bowel Diseases
Matthew W. Carroll and Zachary Hamilton and Hira Gill and Jonathan Simkin and Matthew Smyth and Victor Espinosa and Brian Bressler and Kevan Jacobson
DOI: 10.1097/mib.0000000000000651
02/2016

Activity of SHIP, Which Prevents Expression of Interleukin 1ß, Is Reduced in Patients With Crohn's Disease.
Gastroenterology
Ngoh EN and Weisser SB and Lo Y and Kozicky LK and Jen R and Brugger HK and Menzies SC and McLarren KW and Nackiewicz D and van Rooijen N and Jacobson K and Ehses JA and Turvey SE and Sly LM
DOI: 10.1053/j.gastro.2015.09.049
PubMed: 26481854
02/2016

Pediatric Inflammatory Bowel Disease among South Asians Living in British Columbia, Canada: A Distinct Clinical Phenotype
Inflammatory Bowel Diseases
Carroll, M.W. and Hamilton, Z. and Gill, H. and Simkin, J. and Smyth, M. and Espinosa, V. and Bressler, B. and Jacobson, K.
DOI: 10.1097/MIB.0000000000000651
2016

Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis.
American journal of physiology. Gastrointestinal and liver physiology
Ryz NR and Lochner A and Bhullar K and Ma C and Huang T and Bhinder G and Bosman E and Wu X and Innis SM and Jacobson K and Vallance BA
DOI: 10.1152/ajpgi.00006.2015
PubMed: 26336925
11/2015

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.
Genes and immunity
Ngoh EN and Brugger HK and Monajemi M and Menzies SC and Hirschfeld AF and Del Bel KL and Jacobson K and Lavoie PM and Turvey SE and Sly LM
DOI: 10.1038/gene.2015.30
PubMed: 26226011
10/2015

Mo1791 Ulcerative Colitis-Associated Escherichia coli Colonize the Ileum and Cecum of Infected Mice by Adhering to the Intestinal Epithelium
Gastroenterology
Hengameh Chloé Lauridsen and Hyungjun Yang and Else Bosman and Hongbing Yu and Xiujuan Wu and Caixia Ma and Carsten Struve and Andreas M. Petersen and Karen A. Krogfelt and Kevan Jacobson and Bruce Vallance
DOI: 10.1016/s0016-5085(15)32421-5
04/2015

Vasoactive intestinal peptide prevents PKCe-induced intestinal epithelial barrier disruption during EPEC infection.
American journal of physiology. Gastrointestinal and liver physiology
Morampudi V and Conlin VS and Dalwadi U and Wu X and Marshall KC and Nguyen C and Vallance BA and Jacobson K
DOI: 10.1152/ajpgi.00195.2014
PubMed: 25501546
03/2015

Maternal exposure to fish oil primes offspring to harbor intestinal pathobionts associated with altered immune cell balance
Gut Microbes
DL Gibson and SK Gill and K Brown and N Tasnim and S Ghosh and S Innis and K Jacobson
DOI: 10.1080/19490976.2014.997610
01/2015

Treatment Profile of Pediatric Inflammatory Bowel Disease in Saudi Arabia: Issues in Treatment Adherence
Advances in Pharmacology and Pharmacy
Mohammed Hasosah and Mohammed El Mouzan and Omar Saadah and Khalid Al-Saleem and Abdulrahman Al-Hussaini and Ali Al Mehaidib and Badr Al Saleem and Khalid Alquair and Kevan Jacobson
DOI: 10.13189/app.2015.030402
2015

Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice
PLoS ONE
Wu, X. and Conlin, V.S. and Morampudi, V. and Ryz, N.R. and Nasser, Y. and Bhinder, G. and Bergstrom, K.S. and Yu, H.B. and Waterhouse, C.C.M. and Buchan, A.M.J. and Popescu, O.E. and Gibson, W.T. and Waschek, J.A. and Vallance, B.A. and Jacobson, K.
DOI: 10.1371/journal.pone.0125225
2015

Prevalence and risk factors of helicobacter pylori infection in saudi children: A three-year prospective controlled study
Helicobacter
Hasosah, M. and Satti, M. and Shehzad, A. and Alsahafi, A. and Sukkar, G. and Alzaben, A. and Sunaid, A. and Ahmed, A. and Althubiti, S. and Mufti, A. and Jacobson, K.
DOI: 10.1111/hel.12172
2015

P-057A: Detecting inflammation in pediatric inflammatory bowel disease: the role of fecal calprotectin and its impact on management
Journal of Crohn's and Colitis
A.J. Foster and K. Jacobson
DOI: 10.1016/s1873-9946(14)50074-8
09/2014

C reactive protein as a predictor of response to infliximab in pediatric Crohn’s disease
Journal of Crohn's and Colitis
DOI: 10.1016/s1873-9946(14)50084-0
09/2014

Antivirulence activity of the human gut metabolome.
mBio
Antunes LC and McDonald JA and Schroeter K and Carlucci C and Ferreira RB and Wang M and Yurist-Doutsch S and Hira G and Jacobson K and Davies J and Allen-Vercoe E and Finlay BB
DOI: 10.1128/mbio.01183-14
PubMed: 25073640
07/2014

Intestinal Epithelium-Specific MyD88 Signaling Impacts Host Susceptibility to Infectious Colitis by Promoting Protective Goblet Cell and Antimicrobial Responses
Infection and Immunity
Ganive Bhinder and Martin Stahl and Ho Pan Sham and Shauna M. Crowley and Vijay Morampudi and Udit Dalwadi and Caixia Ma and Kevan Jacobson and Bruce A. Vallance
DOI: 10.1128/iai.02045-14
06/2014

Tu1195 The Influence of Adolescent Transition Clinics on the Attitudes and Beliefs in Medicine in Patients With Inflammatory Bowel Disease
Gastroenterology
Nancy Fu and Kevan Jacobson and Andrew M. Round and Kathi Evans and Hong Qian and Brian Bressler
DOI: 10.1016/s0016-5085(14)62816-x
05/2014

25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study.
The Journal of pediatrics
Wingate KE and Jacobson K and Issenman R and Carroll M and Barker C and Israel D and Brill H and Weiler H and Barr SI and Li W and Lyon MR and Green TJ
DOI: 10.1016/j.jpeds.2013.11.071
PubMed: 24423431
04/2014

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Journal of Visualized Experiments
Vijay Morampudi and Ganive Bhinder and Xiujuan Wu and Chuanbin Dai and Ho Pan Sham and Bruce A. Vallance and Kevan Jacobson
DOI: 10.3791/51297
02/2014

Role of Omega-6 and Omega-3 Fatty Acids in Inflammatory Bowel Disease
Pharma-Nutrition
Kevan Jacobson and Philip C. Calder
DOI: 10.1007/978-3-319-06151-1_5
2014

Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses
Infection and Immunity
Bhinder, G. and Stahl, M. and Sham, H.P. and Crowley, S.M. and Morampudi, V. and Dalwadi, U. and Ma, C. and Jacobson, K. and Vallance, B.A.
DOI: 10.1128/IAI.02045-14
2014

Antivirulence activity of the human gut metabolome
mBio
Caetano M. Antunes, L. and McDonald, J.A.K. and Schroeter, K. and Carlucci, C. and Ferreira, R.B.R. and Wang, M. and Yurist-Doutsch, S. and Hira, G. and Jacobson, K. and Davies, J. and Allen-Vercoe, E. and Brett Finlay, B.
DOI: 10.1128/mBio.01183-14
2014

P-136 Attainment of Steroid-Free Clinical Remission and Normal Growth Among Canadian Children with Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Walters Thomas and Benchimol Eric and Jacobson Kevan and El-Matary Wael and Deslandres Colette and Huynh Hien and Church Peter and Carroll Matthew and Wine Eytan and Mack David and Griffiths Anne
DOI: 10.1097/01.mib.0000456870.74875.ed
2014

Pediatric inflammatory bowel disease in the western region of Saudi Arabia. A retrospective analysis.
Saudi Medical Journal
Hasosah MY and Sukkar GA and Alsahafi AF and Kutbi SY and Alzabn AA and Jacobson K
PubMed: 23756933
06/2013

925e Altered intestinal epithelial homeostasis in mice with a target mutation in the gene encoding vasoactive intestinal peptide (VIP)
Gastroenterology
Xiujuan Wu and Kevan Jacobson
DOI: 10.1016/s0016-5085(13)60583-1
05/2013

Dietary oils modify the host immune response and colonic tissue damage following Citrobacter rodentium infection in mice
American Journal of Physiology-Gastrointestinal and Liver Physiology
Azita Hekmatdoost and Xiujuan Wu and Vijay Morampudi and Sheila M. Innis and Kevan Jacobson
DOI: 10.1152/ajpgi.00292.2012
05/2013

The Relationship Between Common IBD-Associated Risk Alleles and Intestinal Permeability in a Cohort of Healthy First Degree Relatives of Individuals With Crohn's Disease
Gastroenterology
DOI: 10.1016/s0016-5085(13)63107-8
05/2013

Inflammatory Bowel Disease in the Pediatric South Asian Population of British Columbia, Canada: A Distinct and Severe Phenotype
Gastroenterology
DOI: 10.1016/s0016-5085(13)62389-6
05/2013

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis
Journal of Visualized Experiments
Ganive Bhinder and Ho Pan Sham and Justin M. Chan and Vijay Morampudi and Kevan Jacobson and Bruce A. Vallance
DOI: 10.3791/50222
02/2013

Magnetic Resonance Imaging of the Perineum in Pediatric Patients with Inflammatory Bowel Disease
Canadian Journal of Gastroenterology
Douglas H Jamieson and Peter Shipman and Kevan Jacobson
DOI: 10.1155/2013/624141
2013

Clinical nutrition knowledge of gastroenterology fellows: is there anything omitted?
Acta medica Iranica
Eslamian G and Jacobson K and Hekmatdoost A
PubMed: 24338195
2013

Changing incidence of inflammatory bowel disease: Environmental influences and lessons learnt from the South Asian population
Frontiers in Pediatrics
Foster, A. and Jacobson, K.
DOI: 10.3389/fped.2013.00034
2013

Pediatric inflammatory bowel disease in the western region of Saudi Arabia. A retrospective analysis
Saudi Medical Journal
Hasosah, M.Y. and Sukkar, G.A. and Alsahafi, A.F. and Kutbi, S.Y. and Alzabn, A.A. and Jacobson, K.
2013

The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis.
Journal of visualized experiments : JoVE
Bhinder, G. and Sham, H.P. and Chan, J.M. and Morampudi, V. and Jacobson, K. and Vallance, B.A.
2013

Clinical nutrition knowledge of gastroenterology fellows: Is there anything omitted?
Acta Medica Iranica
Eslamian, G. and Jacobson, K. and Hekmatdoost, A.
2013

Clinical nutrition knowledge of gastroenterology fellows: is there anything omitted?
Acta medica Iranica
Eslamian G and Jacobson K and Hekmatdoost A
PubMed: 24338195
2013

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses.
American journal of physiology. Gastrointestinal and liver physiology
Ryz NR and Patterson SJ and Zhang Y and Ma C and Huang T and Bhinder G and Wu X and Chan J and Glesby A and Sham HP and Dutz JP and Levings MK and Jacobson K and Vallance BA
DOI: 10.1152/ajpgi.00320.2012
PubMed: 23019194
12/2012

Gastroesophageal Reflux Disease in Children and Adolescents
Pediatric Drugs
Matthew W. Carroll and Kevan Jacobson
DOI: 10.2165/11594360-000000000-00000
04/2012

Transient appearance of GPI-deficient population in a patient with azathioprine-associated bone marrow aplasia
Annals of Hematology
Arwa Z. Al Riyami and Kevan Jacobson and Jason Ford and Bakul I. Dalal
DOI: 10.1007/s00277-012-1449-7
04/2012

Perinatal cytomegalovirus hepatitis in Saudi infants: A case series
Saudi Journal of Gastroenterology
MohammedY Hasosah and AbdulfattahW Al-Amri and AshrafF Alsahafi and KhaledJ Alghamdi and SuzaneY Kutbi and GhassanA Sukkar and Kevan Jacobson
DOI: 10.4103/1319-3767.96461
2012

Seroconversion of hepatitis B envelope antigen (HBeAg) by entecavir in a child with chronic hepatitis B
Saudi Journal of Gastroenterology
Hasosah, M.Y. and Ghandourah, H.S. and Alsahafi, A.F. and Sukkar, G. and Jacobson, K.
DOI: 10.4103/1319-3767.96465
2012

Helicobacter pylori in First Nations and recent immigrant populations in Canada
Canadian Journal of Gastroenterology
Jones, N.L. and Chiba, N. and Fallone, C. and Thomson, A. and Hunt, R. and Jacobson, K. and Goodman, K.
DOI: 10.1155/2012/174529
2012

Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative Colitis
Clinical Gastroenterology and Hepatology
DOI: 10.1016/j.cgh.2011.11.026
2012

SHIP-Deficient Mice Develop Spontaneous Intestinal Inflammation and Arginase-Dependent Fibrosis
The American Journal of Pathology
Keith W. McLarren and Alexandra E. Cole and Shelley B. Weisser and Nicole S. Voglmaier and Victoria S. Conlin and Kevan Jacobson and Oana Popescu and Jean-Luc Boucher and Laura M. Sly
DOI: 10.1016/j.ajpath.2011.03.018
07/2011

Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection
Case Reports in Gastrointestinal Medicine
Mohammed Hasosah and Abdullah Baothman and Mohamed Satti and Suzanne Kutbi and Khaled Alghamdi and Kevan Jacobson
DOI: 10.1155/2011/945752
2011

Loss of Single Immunoglobulin Interlukin-1 Receptor-Related Molecule Leads to Enhanced Colonic Polyposis in Apcmin Mice
Gastroenterology
Hui Xiao and Weiguo Yin and Mohammed A. Khan and Muhammet F. Gulen and Hang Zhou and Ho Pan Sham and Kevan Jacobson and Bruce A. Vallance and Xiaoxia Li
DOI: 10.1053/j.gastro.2010.04.043
08/2010

Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats
American Journal of Physiology-Gastrointestinal and Liver Physiology
Sheila M. Innis and Chuanbin Dai and Xiujuan Wu and Alison M. J. Buchan and Kevan Jacobson
DOI: 10.1152/ajpgi.00258.2010
2010

Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis.
American journal of physiology. Gastrointestinal and liver physiology
Conlin VS and Wu X and Nguyen C and Dai C and Vallance BA and Buchan AM and Boyer L and Jacobson K
DOI: 10.1152/ajpgi.90551.2008
PubMed: 19661153
10/2009

Esophageal candidiasis in an immunocompetent girl
World Journal of Pediatrics
Mohammed Yahya Hasosah and Mahmmod Showail and Ashraf Al-sahafi and Mohammed Satti and Kevan Jacobson
DOI: 10.1007/s12519-009-0031-4
05/2009

Persistent elevated tissue-transglutaminase in cystic fibrosis.
Journal of paediatrics and child health
Hasosah M and Davidson G and Jacobson K
DOI: 10.1111/j.1440-1754.2009.01477.x
PubMed: 19426374
04/2009

Canadian Association of Gastroenterology Clinical Practice Guidelines: The Use of Tumour Necrosis Factor-Alpha Antagonist Therapy in Crohn’s Disease
Canadian Journal of Gastroenterology
Daniel C Sadowski and Charles N Bernstein and Alain Bitton and Ken Croitoru and Richard N Fedorak and Anne Griffiths and the CAG Crohn’s Consensus Group
DOI: 10.1155/2009/201430
2009

Dietary Lipids in Early Development and Intestinal Inflammatory Disease
Nutrition Reviews
Sheila M. Innis and Kevan Jacobson
DOI: 10.1111/j.1753-4887.2007.tb00361.x
06/2008

Response to Dr. Rashid and Colleagues
The American Journal of Gastroenterology
Vered Pinsk and Kevan Jacobson
DOI: 10.1111/j.1572-0241.2007.01562_4.x
01/2008

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors.
American journal of physiology. Gastrointestinal and liver physiology
Wu X and Vallance BA and Boyer L and Bergstrom KS and Walker J and Madsen K and O'Kusky JR and Buchan AM and Jacobson K
DOI: 10.1152/ajpgi.00173.2007
PubMed: 18032474
01/2008

Helicobacter PyloriInfection in Canadian and Related Arctic Aboriginal Populations
Canadian Journal of Gastroenterology
Karen J Goodman and Kevan Jacobson and Sander Veldhuyzen van Zanten
DOI: 10.1155/2008/258610
2008

Low prevalence of Helicobacter pylori infection in Canadian children: A cross-sectional analysis
Canadian Journal of Gastroenterology
Segal, I. and Otley, A. and Issenman, R. and Armstrong, D. and Espinosa, V. and Cawdron, R. and Morshed, M.G. and Jacobson, K.
DOI: 10.1155/2008/410176
2008

The effect of dietary oils on cecal microflora in experimental colitis in mice
Indian Journal of Gastroenterology
Hekmatdoost, A. and Feizabadi, M.M. and Djazayery, A. and Mirshafiey, A. and Eshraghian, M.R. and Yeganeh, S.M. and Sedaghat, R. and Jacobson, K.
2008

Improvement in Biomarkers of Bone Formation During Infliximab Therapy in Pediatric Crohn's Disease: Results of the REACH Study
Clinical Gastroenterology and Hepatology
Meena Thayu and Mary B. Leonard and Jeffrey S. Hyams and Wallace V. Crandall and Subra Kugathasan and Anthony R. Otley and Allan Olson and Jewel Johanns and Colleen W. Marano and Robert B. Heuschkel and Gigi Veereman–Wauters and Anne M. Griffiths and Robert N. Baldassano
DOI: 10.1016/j.cgh.2008.07.010
2008

The effect of dietary oils on cecal microflora in experimental colitis in mice.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Hekmatdoost A and Feizabadi MM and Djazayery A and Mirshafiey A and Eshraghian MR and Yeganeh SM and Sedaghat R and Jacobson K
PubMed: 19112187
2008

Surgical intervention in children with Crohn's disease.
International journal of colorectal disease
Leonor R and Jacobson K and Pinsk V and Webber E and Lemberg DA
DOI: 10.1007/s00384-007-0281-3
PubMed: 17530264
09/2007

Differential responses of VIPergic and nitrergic neurons in paediatric patients with Crohn's disease
Autonomic Neuroscience
Lee Boyer and Dolar Sidpra and Gareth Jevon and Alison M. Buchan and Kevan Jacobson
DOI: 10.1016/j.autneu.2007.03.001
07/2007

Inflammatory Bowel Disease in the South Asian Pediatric Population of British Columbia
The American Journal of Gastroenterology
Vared Pinsk and Daniel A. Lemberg and Karan Grewal and Collin C. Barker and Richard A. Schreiber and Kevan Jacobson
DOI: 10.1111/j.1572-0241.2007.01124.x
05/2007

Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohn’s Disease in Children
Gastroenterology
Jeffrey Hyams and Wallace Crandall and Subra Kugathasan and Anne Griffiths and Allan Olson and Jewel Johanns and Grace Liu and Suzanne Travers and Robert Heuschkel and James Markowitz and Stanley Cohen and Harland Winter and Gigi Veereman–Wauters and George Ferry and Robert Baldassano
DOI: 10.1053/j.gastro.2006.12.003
03/2007

Pediatric Gastroenterology – are you Kidding?
Canadian Journal of Gastroenterology
Kevan Jacobson and Paul C Adams
DOI: 10.1155/2007/823540
2007

Canadian pediatric gastroenterology workforce: Current status, concerns and future projections
Canadian Journal of Gastroenterology
Morinville, V. and Drouin, ?. and Lévesque, D. and Espinosa, V.M. and Jacobson, K.
DOI: 10.1155/2007/292054
2007

Dietary lipids and intestinal inflammatory disease
The Journal of Pediatrics
Sheila M. Innis and Vered Pinsk and Kevan Jacobson
DOI: 10.1016/j.jpeds.2006.06.058
11/2006

UPPER GASTROINTESTINAL BIOPSIES AND PEDIATRIC CROHN'S DISEASE
Journal of Pediatric Gastroenterology and Nutrition
Mohammed Hasosah and Anne Gomez and Gareth Jevon and Kevan Jacobson
DOI: 10.1097/00005176-200610000-00160
10/2006

Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map).
Cellular microbiology
Ma C and Wickham ME and Guttman JA and Deng W and Walker J and Madsen KL and Jacobson K and Vogl WA and Finlay BB and Vallance BA
DOI: 10.1111/j.1462-5822.2006.00741.x
PubMed: 16759225
10/2006

The Congenital Intrahepatic Arterioportal Fistula Syndrome
Journal of Pediatric Gastroenterology and Nutrition
Seamus P. Norton and Kevan Jacobson and Stanley P. Moroz and Gordon Culham and Vicky Ng and Justine Turner and Philip John
DOI: 10.1097/01.mpg.0000221890.13630.ad
08/2006

Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat
Autonomic Neuroscience
Paul R. Saunders and Paula Miceli and Bruce A. Vallance and Lu Wang and Sarah Pinto and Gervais Tougas and Markad Kamath and Kevan Jacobson
DOI: 10.1016/j.autneu.2005.12.002
01/2006

A Randomized Trial of Yoga for Adolescents with Irritable Bowel Syndrome
Pain Research and Management
Leora Kuttner and Christine T Chambers and Janine Hardial and David M Israel and Kevan Jacobson and Kathy Evans
DOI: 10.1155/2006/731628
2006

Clinical Quiz
Journal of Pediatric Gastroenterology and Nutrition
T G Lokesh Babu and Kevan Jacobson
DOI: 10.1097/01.mpg.0000147132.59353.b9
11/2005

THE CHANGING PATTERN OF PEDIATRIC IBD AT BRITISH COLUMBIA CHILDRENS HOSPITAL
Journal of Pediatric Gastroenterology and Nutrition
Vered Pinsk and Daniel A Lemberg and Collin Barker and Richard Schreiber and David M Israel and Kevan Jacobson
DOI: 10.1097/01.mpg.0000182024.84053.a4
10/2005

Pediatric Inflammatory Bowel Disease: The British Columbia Experience
Journal of Pediatric Gastroenterology and Nutrition
DOI: 10.1097/01.mpg.0000182025.84053.ed
10/2005

Positron Emission Tomography in the Investigation of Pediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases
Daniel A Lemberg and Robert M Issenman and Ruth Cawdron and Tim Green and John Mernagh and Stephen J Skehan and Claude Nahmias and Kevan Jacobson
DOI: 10.1097/01.mib.0000172810.49619.cb
08/2005

Endoscopic Hemostasis in a Neonate with a Bleeding Duodenal Ulcer
Journal of Pediatric Gastroenterology and Nutrition
T G Lokesh Babu and Kevan Jacobson and Min Phang and Mark R Riley and Collin C Barker
DOI: 10.1097/01.mpg.0000173602.39271.ff
08/2005

Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet
American Journal of Physiology-Gastrointestinal and Liver Physiology
Kevan Jacobson and Harmeet Mundra and Sheila M. Innis
DOI: 10.1152/ajpgi.00459.2004
07/2005

Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
Bourke B and Ceponis P and Chiba N and Czinn S and Ferraro R and Fischbach L and Gold B and Hyunh H and Jacobson K and Jones NL and Koletzko S and Lebel S and Moayyedi P and Ridell R and Canadian Helicobacter Study Group
PubMed: 16010300
07/2005

Myenteric plexus injury and apoptosis in experimental colitis
Autonomic Neuroscience
Lee Boyer and Mehran Ghoreishi and Valerie Templeman and Bruce A. Vallance and Alison M. Buchan and Gareth Jevon and Kevan Jacobson
DOI: 10.1016/j.autneu.2004.10.006
01/2005

The Changing Prevalence of Helicobacter Pylori Infection in Canadian Children: Should Screening Be Performed in High-Risk Children?
Canadian Journal of Gastroenterology
Kevan Jacobson
DOI: 10.1155/2005/840909
2005

Positron emission tomography in the investigation of pediatric inflammatory bowel disease
Inflammatory Bowel Diseases
Lemberg, D.A. and Issenman, R.M. and Cawdron, R. and Green, T. and Mernagh, J. and Skehan, S.J. and Nahmias, C. and Jacobson, K.
DOI: 10.1097/01.MIB.0000172810.49619.cb
2005

Clinical quiz
Journal of Pediatric Gastroenterology and Nutrition
Babu, T.G.L. and Jacobson, K.
DOI: 10.1097/01.MPG.0000147132.59353.B9
2005

Erratum: Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents - An evidence-based evaluation (Canadian Journal of Gastroenterology (2005) vol. 19 (7) (399-408))
Canadian Journal of Gastroenterology
Jones, N.L. and Sherman, P. and Fallone, C.A. and Bourke, B. and Ceponis, P. and Chiba, N. and Czinn, S. and Ferraro, R. and Fischbach, L. and Gold, B. and Hyunh, H. and Jacobson, K. and Jones, N. and Koletzko, S. and Lebel, S. and Moayyedi, P. and Ridell, R. and Sherman, P. and van Zanten, S. and Beck, I. and Best, L. and Boland, M. and Bursey, F. and Chaun, H. and Cooper, G. and Craig, B. and Creuzenet, C. and Critch, J. and Govender, K. and Hassall, E. and Kaplan, A. and Keelan, M. and Noad, G. and Robertson, M. and Smith, L. and Stein, M. and Taylor, D. and Walters, T. and Persaud, R. and Whitaker, S. and Woodland, R.
2005

Intramural esophageal hematoma (IEH).
Journal of pediatric gastroenterology and nutrition
Lokesh Babu, T.G. and Jacobson, K.
2005

Canadian Helicobacter Study Group Consensus Conference: Update on the Approach to Helicobacter Pylori Infection in Children and Adolescents – an Evidence-Based Evaluation
Canadian Journal of Gastroenterology
Nicola L Jones and Philip Sherman and Carlo A Fallone and Nigel Flook and Fiona Smaill and Sander Veldhuyzen van Zanten and Richard Hunt and Alan Thomson and Canadian Helicobacter Study Group
DOI: 10.1155/2005/390932
2005

Cytomegalovirus-Associated Hemophagocytic Syndrome in a Child With Crohn Disease Receiving Azathioprine
Journal of Pediatric Gastroenterology and Nutrition
T. G. Lokesh Babu and Dana Boctor and Alyson Davey and Mason C. Bond and Kevan Jacobson
DOI: 10.1097/00005176-200410000-00020
10/2004

Say Goodbye and Say Hello: The Transition from Pediatric to Adult Gastroenterology
Canadian Journal of Gastroenterology
Jorge L Pinzon and Kevan Jacobson and John Reiss
DOI: 10.1155/2004/474232
2004

Canadian Helicobacter Study Group consensus conference: Update on the management of Helicobacter pylori - An evidence-based evaluation of six topics relevant to clinical outcomes in patients evaluated for H pylori infection
Canadian Journal of Gastroenterology
Hunt, R. and Fallone, C. and Hunt, R. and Fallone, C. and van Zanten, S.V. and Sherman, P. and Smaill, F. and Flook, N. and Thomson, A. and Armstrong, D. and Barkun, A. and Boland, M. and Bosworth, T. and Bourdages, R. and Bridges, R. and Buchan, A. and Bursey, F. and Chaun, H. and Chiba, N. and Chlebo, J. and Cooper, G. and Craig, B. and Deslandres, C. and DeVinney, R. and Erickson, L. and Fallone, C. and Fischbach, L. and Flook, N. and Govender, K. and Hunt, R. and Jacobson, K. and Jones, N. and Klompus, S. and Leduc, N. and Lin, F. and Louw, J. and McCammon, R. and Meddings, J. and Nevin, K. and Noad, G. and Ponich, T. and Serrar, J. and Sherman, P. and Smith, L. and Smith, W. and Spenard, J. and Stein, M. and Streutker, C. and Thomson, P. and Whittaker, S. and Williams, N. and Woodland, R.
DOI: 10.1155/2004/326767
2004

Curcumin attenuates DNB-induced murine colitis.
American journal of physiology. Gastrointestinal and liver physiology
Salh B and Assi K and Templeman V and Parhar K and Owen D and Gómez-Muñoz A and Jacobson K
DOI: 10.1152/ajpgi.00449.2002
PubMed: 12637253
07/2003

Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium.
Infection and immunity
Vallance BA and Deng W and Jacobson K and Finlay BB
DOI: 10.1128/iai.71.6.3443-3453.2003
PubMed: 12761129
06/2003

Comparison of Multidetector CT and Barium Studies of the Small Bowel: Inflammatory Bowel Disease in Children
American Journal of Roentgenology
DOI: 10.2214/ajr.180.5.1801211
05/2003

Esophageal Crohn Disease in Children: A Clinical Spectrum
Journal of Pediatric Gastroenterology and Nutrition
Kannan Ramaswamy and Kevan Jacobson and Gareth Jevon and David Israel
DOI: 10.1097/00005176-200304000-00006
04/2003

Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats
Autonomic Neuroscience
P.C Miceli and K Jacobson
DOI: 10.1016/s1566-0702(03)00023-7
04/2003

Neutrophil granulocytes mediate enteric nervous system injury in a murine model of colitis
Gastroenterology
Kevan Jacobson and Lee C. Boyer and Mehran Ghoreishi and Valerie Templeman and Bruce A. Vallance and Gareth Jevon
DOI: 10.1016/s0016-5085(03)81636-0
04/2003

Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats
Autonomic Neuroscience: Basic and Clinical
Miceli, P.C. and Jacobson, K.
DOI: 10.1016/S1566-0702(03)00023-7
2003

Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium
Infection and Immunity
Vallance, B.A. and Deng, W. and Jacobson, K. and Finlay, B.B.
DOI: 10.1128/IAI.71.6.3443-3453.2003
2003

Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice.
Infection and immunity
Vallance BA and Deng W and De Grado M and Chan C and Jacobson K and Finlay BB
DOI: 10.1128/iai.70.11.6424-6435.2002
PubMed: 12379723
11/2002

Etiology of dyspepsia: implications for empirical therapy
Canadian Journal of Gastroenterology
09/2002

Evidence-based feeding practice guidelines for very-low birth weight infants
Advances in Neonatal Care
DOI: 10.1053/adnc.2002.31511
02/2002

A matched cohort study of feeding practice guidelines for infants weighing less than 1,500g
Advances in Neonatal Care
DOI: 10.1053/adnc.2002.31510
02/2002

Epstein-Barr Virus Infection in Transplant Recipients: Sumary of a Workshop on Surveillance, Prevention and Treatment
Canadian Journal of Infectious Diseases
Upton Allen and Caroline Alfieri and Jutta Preiksaitis and Atul Humar and Dorothy Moore and Bruce Tapiero and Raymond Tellier and Michael Green and Dele Davies and Diane Hébert and Sheila Weitzman and Martin Petric and Kevan Jacobson and Canadian PTLD Workshop Group #x2013; 1999
DOI: 10.1155/2002/634318
2002

Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen Citrobacter rodentium in infected mice
Infection and Immunity
Vallance, B.A. and Deng, W. and De Grado, M. and Chan, C. and Jacobson, K. and Finlay, B.B.
DOI: 10.1128/IAI.70.11.6424-6435.2002
2002

The changing face of celiac disease
Paediatrics & Child Health
Rameeta Lad and Kevan Jacobson
DOI: 10.1093/pch/6.9.644
11/2001

INFECTIOUS DIARRHEA IN CHILDREN
Gastroenterology Clinics of North America
Kannan Ramaswamy and Kevan Jacobson
DOI: 10.1016/s0889-8553(05)70201-6
09/2001

Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system
Gastroenterology
Jan D. Huizinga and Irene Berezin and Kanishka Sircar and Bryan Hewlett and Graeme Donnelly and Premysl Bercik and Catherine Ross and Talal Algofi and Peter Fitzgerald and Tara Der and Robert H. Riddell and Stephen M. Collins and Kevan Jacobson
DOI: 10.1053/gast.2001.21200
02/2001

Gastric Acid Secretory Response inHelicobacter pylori-Positive Patients with Duodenal Ulcer Disease
Canadian Journal of Gastroenterology
Kevan Jacobson and Naoki Chiba and Ying Chen and Miguel Barrientos and Cindy James and Robert H Riddell and Richard H Hunt
DOI: 10.1155/2001/764615
2001

Infectious diarrhea in children
Gastroenterology Clinics of North America
Ramaswamy, K. and Jacobson, K.
DOI: 10.1016/S0889-8553(05)70201-6
2001

Autonomic nervous system (ANS) dysfunction exacerbates inflammation in dextran sulfate (DSS) model of ulcerative colitis
Gastroenterology
Paula C. Miceli and Paul Saunders and Veljko Djuric and Kevan Jacobson
DOI: 10.1016/s0016-5085(00)85665-6
04/2000

Stress reactivation colitis and the role of the autonomic nervous system (ANS)
Gastroenterology
Paul Saunders and Markad Kamath and Kevan Jacobson
DOI: 10.1016/s0016-5085(00)85664-4
04/2000

An Unusual Cause of Recurrent Pancreatitis: Duodenal Duplication Cyst
Canadian Journal of Gastroenterology
Rameeta J Lad and Peter Fitzgerald and Kevan Jacobson
DOI: 10.1155/2000/152809
2000

Omeprazole for treatment of chronic erosive esophagitis in children: A multicenter study of efficacy, safety, tolerability and dose requirements
The Journal of Pediatrics
Eric Hassall and David Israel and Ross Shepherd and Michael Radke and Agneta Dalväg and Birgitta Sköld and Ola Junghard and Per Lundborg
DOI: 10.1067/mpd.2000.109607
2000

18F-fluorodeoxyglucose positron tomography in diagnosis of paediatric inflammatory bowel disease
The Lancet
Robert Issenman and John Mernagh and Claude Nahmias and Kevan Jacobson and Stephen J Skehan
DOI: 10.1016/s0140-6736(99)80021-x
09/1999

CanadianHelicobacterStudy Group Consensus Conference on the Approach toHelicobacter PyloriInfection in Children and Adolescents
Canadian Journal of Gastroenterology
P Sherman and E Hassall and RH Hunt and CA Fallone and S Veldhuyzen van Zanten and ABR Thomson and Canadian Helicobacter Study Group
DOI: 10.1155/1999/934285
1999

18F-fluorodeoxyglucose positron tomography in diagnosis of paediatric inflammatory bowel disease
Lancet
Skehan, S.J. and Issenman, R. and Mernagh, J. and Nahmias, C. and Jacobson, K.
DOI: 10.1016/S0140-6736(99)80021-X
1999

Neuroimmune mechanisms in a rat model of stress-induced reactivation of experimental colitis
Gastroenterology
P.C. Miceli and B.A. Vallance and K. Jacobson
DOI: 10.1016/s0016-5085(98)84227-3
04/1998

Neuro-modulation of stress-induced reactivation of experimental colitis
Gastroenterology
DOI: 10.1016/s0016-5085(98)84734-3
04/1998

Patients’ Diets and Preferences in a Pediatric Population with Inflammatory Bowel Disease
Canadian Journal of Gastroenterology
Timothy J Green and Robert M Issenman and Kevan Jacobson
DOI: 10.1155/1998/928706
1998

The mechanism of altered neural function in a rat model of acute colitis.
Gastroenterology
Jacobson K and McHugh K and Collins SM
DOI: 10.1016/s0016-5085(97)70230-0
PubMed: 8978354
01/1997

The mechanism of altered neural function in a rat model of acute colitis
Gastroenterology
Jacobson, K. and McHugh, K. and Collins, S.M.
DOI: 10.1016/S0016-5085(97)70230-0
1997

Positron emission tomography in pediatric inflammatory bowel disease: 40
Journal of Pediatric Gastroenterology and Nutrition
Jacobson, K. and Issenman, R.M. and Radoja, C. and Green, T. and Mernagh, J.R. and Nahmias, C.
DOI: 10.1097/00005176-199710000-00057
1997

Previous inflammation alters the response of the rat colon to stress
Gastroenterology
SM Collins and K McHugh and K Jacobson and I Khan and R Riddell and K Murase and HP Weingarten
DOI: 10.1016/s0016-5085(96)70012-4
1996

Previous inflammation alters the response of the rat colon to stress
Gastroenterology
Collins, S.M. and McHugh, K. and Jacobson, K. and Khan, I. and Riddell, R. and Murase, K. and Weingarten, H.P.
DOI: 10.1016/S0016-5085(96)70012-4
1996

Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat
Gastroenterology
Kevan Jacobson and Kevin McHugh and Stephen M. Collins
DOI: 10.1016/0016-5085(95)90378-x
09/1995

The selective beneficial effects of nitric oxide inhibition in experimental colitis.
The American journal of physiology
Hogaboam CM and Jacobson K and Collins SM and Blennerhassett MG
PubMed: 7537457
04/1995

The selective beneficial effects of nitric oxide inhibition in experimental colitis
American Journal of Physiology - Gastrointestinal and Liver Physiology
Hogaboam, C.M. and Jacobson, K. and Collins, S.M. and Blennerhassett, M.G.
DOI: 10.1152/ajpgi.1995.268.4.g673
1995

Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat
Gastroenterology
Jacobson, K. and McHugh, K. and Collins, S.M.
DOI: 10.1016/0016-5085(95)90378-X
1995

Interpreting abnormalities in routine liver biochemistry
Canadian Family Physician
1992

Research

Current projects
Epidemiology of paediatric IBD

Current Projects
Examining the role of maternal dietary lipid in modulating epithelial barrier function and intestinal immune response of the young offspring to chemically induced colitis

Current Projects
Determining the effect of intestinal inflammation on neuro-epithelial function in animal models of IBD

Honours & Awards

Canadian Children Inflammatory Bowel Disease Network, CIHR and CH.I.L.D Foundation – 2013

Research Group Members

Seerit Boparai, Research Assistant
Justin Chan, Graduate Research Assistant
Osho Chandra, Research Assistant
Karman Gill, Research Assistant
Hannah Kullmann, Research Assistant (co-op student)
Mielle Michaux, Medical Geographer
Olga Radivojevic, Clinical Research Coordinator
Hongbing Yu, Research Associate