• Van Allen, Margot I.


    Investigator, BC Children's Hospital
    Professor, Department of Medical Genetics, University of British Columbia

    Degrees / Designations
    M.Sc., MD
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Lab Phone
    Mailing Address

    Provincial Medical Genetics Program
    BC Children's Hospital and BC Women's Hospital & Health Centre
    Room C234
    4500 Oak Street
    Vancouver, BC V6H 3N1

    Affiliate Websites
    Research Areas
    • Etiology, pathogenesis, prevention and epidemiology of congenital anomalies
    • Neural tube defects
    • Craniofacial disorders
    • Limb abnormalities
    • Multiple congenital anomaly disorders (syndromes)

    I study birth defects, their causes, the natural history of the disorders, and how to prevent them. Based on clinical studies and practice experience I develop guidelines for practice management for treatment and prevention of birth defects and multiple congenital anomaly disorders (also called syndromes).

    Current Projects

    I am evaluating the impact of folic acid food fortification and tablet supplementation on the prevention of neural tube defects in BC and, in collaboration with others, in Canada.

    I am collaborating with my colleagues providing clinical patient material for molecular and cytogenetic studies.

    Selected Publications
    De Wals P, Van Allen M, Lowry R, Evans J, Van den Hof MC, Crowley M, Tairou F, Uh SH, Sibbald B, Zimmer P, Fernandez B, Lee NS, Niyonsenga T.: Impact of folic acid food fortification on the birth prevalence of lipomyelomeningocele in Canada. Birth Defects Research Part A: Clinical and Molecular Teratology. 82(2):106-109, 2008

    Tyson C, Qiao Y, Harvard C, Liu X, Arbour L, Bernier FP, McGillivray B, Farrell SA, Chudley AE, Clarke L, Gibson W, Dyack S, McLeod R, Costa T, Van Allen MI, Yong S-L, Graham GE, MacLeod P, Patel MS, Hurlburt J, Holden JJA, Lewis SME, Rajcan-Separovic E.: Submicroscopic deletions of 11q24-25 in individuals without Jacobsen syndrome: re-examination of the critical region by high-resolution array-CGH. Molecular Cytogenetics. 2008 Nov 11;1:23.

    Lopez E, Van Allen MI:  Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype.  Teratology, in press.

    Koochek M, Harvard C, Hildebrand MJ, Van Allen M, Wingert H, Mickelson E, Holden JJA, Rajcan-Separovic E, Lewis MES:  15q duplication associated with autism in a multiplex family with a familial cryptic translocation t(14;15)(q11.2;q13.3) detected using array CGH.  Clinical Genetics, in press.

    Tyson C, Harvard C, Locker R, Friedman JM, Langlois S, Lewis MES, Van Allen M, Somerville, Arbour L, Clarke L, McGillivray B, Yong S-L, Siegel-Bartelt J, Rajcan-Separovic E:  Submicroscopic deletions and duplications in individuals with intellectual disability detected by array-CGH.  Am J Med Genetics, in press.

    T Philipp, W Feichtinger, MI Van Allen, E Separovic, A Reiner, DK Kalousek.  Abnormal embryonic development diagnosed embryoscopically in early intrauterine deaths after in vitro fertilization:  A preliminary report of 23 cases.  Fertility and Sterility 82(5): 1337-1342, 2004.


    DA Stevenson, TM Anay, J Clayton-Smith, BD Hall, MI Van Allen, EH Zackai, G Frank, CL Cericuzio.  Unexpected death and critical illness in Prader-Willi syndrome:  report of ten individuals.  Am J Med Genet 124A(2):158-164, 2004.

    MI Van Allen, C McCourt, NS Lee.  Major health advances:  Folic acid for primary prevention of neural tube anomalies.  Ottawa, Ontario:  Minister of public works and government services of Canada.  2002.

    MI Van Allen, C McCourt, NS Lee.  Sante avant la grossess:  L’acide folique pour la prevention primaire des anomalies du tube neural.  Ottawa, Ontario:  Ministre des Travaux publics et Services gouvernment au Canada.  2002 (No de cat.  H39-607/2002F).

    Aubertin G, Cripps S, Coleman G, McGillivray B, Yong LS, Van Allen M, Shaw D, Arbour L.  Prenatal diagnosis of apparently isolated unilateral multicystic kidney:  implications for counselling and management.  Prenatal Diagnosis 22:388-394, 2002.

    Ford B, Rupps R, Lirenman D, Van Allen MI, Farquharson D, Lyons C, Friedman MJ.  Renal-coloboma syndrome:  Prenatal detection and clinical spectrum in a large family.  Am J Med Genetics 99:137-141,  2001.

    Ho NC, Francomano CA, Van Allen M:  Jeune Asphyxiating Thoracic Dystrophy and Short-Rib Polydactyly Type III (Verma-Naumoff) are variants of the same disorder.  Am J Med Genet 90(4): 310-314, 2000.

    Honours & Awards

    Fulbright Scholar, Council of International Exchange of Scholars, USA –1995-96

    W.D. Wilson Visiting Scholar, Ernest Oppenheimer Trust Fund, University of the North, South Africa – 1995-96

    Award for Outstanding Achievement by an Investigator (biannual award), BC Research Institute for Child and Family Health – 1996

    Research Group Members