• Delisle, Marie-France

    Titles

    Investigator, BC Children's Hospital
    Clinical Associate Professor, Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of British Columbia

    Degrees / Designations
    MD, FRCSC
    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-3075
    Fax
    604-875-3864
    Lab Phone
    Assistant
    Kerrie Glover
    Assistant Phone
    604-875-3075
    Mailing Address

    BC Women's Hospital & Health Centre
    Room 1U3
    4500 Oak Street
    Vancouver, BC V6H 3N1

    Affiliate Websites
    Research Areas
    • Prenatal diagnosis 
    • Multifetal gestation 
    • Invasive procedures 
    • Clinical trials
    Summary

    Ultrasound and invasive procedures (amniocentesis, chorionic villous sampling) are used to establish the fetus’s well being. My main research interest is to address the aspects of this process. Can we be more precise in counselling when diagnosing specific fetal anomalies? What are the impacts of associated anomalies?

    There are unique aspects of the multiple pregnancy that need to be discussed at the time of the prenatal diagnosis counselling. I have reviewed the maternal and perinatal complications associated with triplet pregnancies at our institution, and amniocentesis for twin pregnancies. I have reviewed if we can use the level of amniotic fluid protein measured at the time of the amniocentesis to ensure that the procedure tested the two fetuses.

    I am also involved in multicenter clinical trials. We are reviewing the use of antenatal steroids for prevention of morbidity associated with prematurity. A recently compiled study assessed the impact of doing external cephalic version at an earlier time in gestation on the caesarean section rate. The results are being analyzed.

    Current Projects

    External Cephalic Version
    I have completed a study assessing the use of regional anesthesia at the time of external cephalic version. We hoped that this could increase the success rate of the procedure.

    Early External Cephalic Version II
    This is a multicenter trial. It will assess whether doing the procedure at an earlier time will ultimately decrease the caesarean section rate for term breech presentations.

    Amniocentesis for twin pregnancy
    We are reviewing our data to evaluate if the level of AFP in the fluid can help in proving that the two sacs were sampled.

    Selected Publications

    Murphy KE, Hannah ME, Willan AR, Hewson SA, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA; MACS Collaborative Group.: Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet. 2008 Dec 20;372(9656):2143-51.

    MF Delisle, L Brosseuk, RD Wilson.  Amniocentesis for twin pregnancies: is alpha-fetoprotein useful in confirming that the two sacs were sampled?  Fetal Diagn Ther 2007;22(3):221-5.

    P von Dadelszen, S Kives , MF Delisle, RD Wilson, R Joy, L Ainsworth et al. The association between early membranes rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabor rupture of membranes. Twin Research 2003; 6: 257-262.

    MW Bebbington, N Kent , K Lim, A Gagnon, MF Delisle, F Tessier, RD Wilson. A randomized Controlled Trial comparing two protocols for the use of misoprostol in mid-trimester pregnancy termination. Am J Obstet & Gynaecol 2002: 187:853-857.

    K Butt, A Gagnon, MF Delisle. Failure of Methotrexate and Internal Iliac Balloon Catheterization to manage Placenta Percreta. Obstet Gynecol 2002; 99: 981-982.

    D Bloomenthal, MF Delisle, F Tessier, P Tsang. Obstetric Implications of the Factor V Leiden Mutation: A Review. Am J Perin 2002; 19:37 -47.

    MF Delisle, F Valimohamed. D Money, MJ Douglas. Central Nervous System Complications of von Hippel-Lindau Disease and Pregnancy: Perinatal Considerations: Case report and Literature Review. J Matern-Fetal Med. 2002; 9: 242-247.

    K Mujaibel, A Benjamin, MF Delisle, K Williams. Lung Cancer in Pregnancy. Case report and review of the literature. J Maternal Fetal Medicine 2001; 10: 426-432.

    MF Delisle, RD Wilson . Invasive First Trimester Diagnosis: Early Amniocentesis. Seminars in Perinatology 1999;23: 414-423.

    Brown R, Gagnon R, Delisle MF. Insuffisance cervicale et cerclage cervical. J Obstet Gynaecol Can. 2016 Dec. PMID: 28063549 

    Grants
    Honours & Awards

    Award of Excellence for Contribution in Education, Education Services, Children’s & Women’s Heath Centre of British Columbia - May 2003

    National Faculty Award of Excellency in Resident Education, The Council of Resident Education In Obstetrics and Gynecology - June 2001

    Maternal-Fetal Medicine Research Award

    Research Group Members