• Ipsiroglu, Osman

    Titles

    Investigator, BC Children's Hospital
    Clinical Associate Professor, Division of Developmental Paediatrics, Department of Pediatrics, Faculty of Medicine, University of British Columbia
    Adjunct Professor, Faculty of Science, Thompson Rivers University

    Degrees / Designations
    MD, FRCPC, PhD, MBA, MAS
    Primary Area of Research
    Brain, Behaviour & Development
    Secondary Area(s) of Research
    Phone
    604-453-8303
    Fax
    Lab Phone
    Assistant
    Mai Berger
    Assistant Phone
    604-453-8300, ext. 8408
    Mailing Address

    Sunny Hill Health Centre for Children
    Rm M-111
    3644 Slocan Street
    Vancouver, BC  V5M 3E8

    Affiliate Websites
    Research Areas

    Paediatric Sleep: Pathophysiology and treatment of sleep disorders; impact of sleep disorders on the developing brain; comprehensive functional sleep/wake behaviour assessments using qualitative and quantitative methdologies, including medical ethnography, therapeutic emplotment and the concept of ecologies; health care services management (adherence/compliance, decision making, ethics) in children with neurodevelopmental disabilities/disorders

    Summary

    Based on my interest in adherence research, socio-cultural aspects of medicine, child development and neurology (Ref# 1,2,3,4) I developed, in collaboration with medical anthropology and educational psychology, a comprehensive functional sleep/wake-behaviours assessment concept and began to transform physiological knowledge with questions of sleep health and management (Ref# 3,4,6,7).

    In collaboration with the Cognitive Systems Lab at UBC, I have developed a 'Virtual-Sleep-Lab', where Videosomnography is used for screening ‘visible’ and ‘recognizable’ sleep disorders in children with neurodevelopmental disabilities/disorders in their natural setting, at home (Ref# 8,9,10). Based on this research, the Inter. RLS Consensus Group has included children with NDD in their recent Consensus Statement.

    Current Projects

    NeuroDevNet "Better Days/Better Nights"

    SWAPPs 4KIDS with NDDs. Structured functional Sleep/Wake Behaviour assessment in children with neurodevelopmental disabilities/disorders & monitoring therapeutic interventions.

    Overview: Our team has developed a web app (sleep/wake behaviours App, SWAPP) to facilitate recognition, characterization and monitoring of sleep problems (SPs) and daytime sequelae in children and youth with neurodevelopmental disabilities (NDDs) [http://youtu.be/60Kx4jmU6Is]. The use of the SWAPP in clinical practice has created evidence for revisiting clinical practice guidelines and improving existing policies by highlighting the fundamental need, to recognize and appropriately treat sleep problems in most vulnerable populations. We collaborate with a network of multidisciplinary stakeholders, including non-governmental organizations (representing patients) and recently with decision makers to ensure rapid and sustainable implementation and policy change.

    Objectives of our research: Further development of the SWAPP and associated database. We are particularly interested in medication strategies, captured by the medication module for monitoring psychotropic drug prescriptions and behavioural / neurologic adverse drug reactions. A free downloadable smart-phone version of our SWAPP for caregivers and practitioners to (self-)assess / recognize the concept of challenging sleep / wake behaviours will be ready around fall 2015.

    Significance: At the end of the project we will have a series of validated and commercially available SWAPPs with patient driven self-assessment modules for participatory data collection on poorly understood challenging-disruptive sleep/wake behaviours. Patient and community tier input during all stages of development will result in effective implementation of the SWAPPs through knowledge translation activities in collaboration with non-governmental organizations.

    Selected Publications
    1. Stockler S , Moeslinger D , Herle M , Wimmer B & Ipsiroglu OS.:Cultural aspects in the management of inborn errors of metabolism. J. Inherit. Metab. Dis. 2012 November; 35(6).
    2. Jan JE , Bax MC , Owens JA , Ipsiroglu OS , Wasdell MB.: Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities. Eur. J. Paediatr. Neurol. 2012 September; 16(5).
    3. Jan JE , Asante KO , Conry JL , Fast DK , Bax MC , Ipsiroglu OS , Bredberg E, Loock CA , Wasdell MB.:  Sleep Health Issues for Children with FASD: Clinical Considerations. Int J Pediatr.: 2010 July; 2010.
    4. Jan JE, Owens JA , Weiss MD , Johnson KP , Wasdell MB , Freeman RD, Ipsiroglu OS.: Sleep hygiene for children with neurodevelopmental disabilities. Pediatrics. 2008 December; 122(6): 1343-50.
    5. Ipsiroglu OS , McKellin WH , Carey N , Loock C.: “They silently live in terror…” why sleep problems and night-time related quality-of-life are missed in children with a fetal alcohol spectrum disorder. Soc. Sci. Med. 2013 February; 79: 76-83.
    6. Ipsiroglu OS, Carey N, Collet JP, Fast D, Garden J, Jan JE, Kuttner L, Loock C, Lucyshyn J, Schlarb A, Witmans M.: De-medicalizing sleep: sleep assessment tools in the community setting for clients (patients) with FASD & prenatal substance exposure. NOFAS-UK: Fetal Alcohol Forum. 2012 June; 7: 33-41.
    7. Ipsiroglu OS, Jan JE, Freeman RD, Laswick A, Milner R, Mitton C, Wasdell MB, Wensley DF, McKellin WH.: How to approach pediatric sleep in British Columbia: a consensus paper. B. C. Med. J. 2009November; 50(9): 512-516.
    8. Ipsiroglu OS, Black A, Vilela-Barbosa A, Vatikiotis-Bateson E, McKellin W.:  Describing Restless Legs Syndrome (RLS) as a Cause of Circadian Rhythm Sleep Disorders (CRSD): Video Studies in the Home Setting: From Ethnography to Quantitative Analyses [abstract]. Sleep Med. September 2011; 12(Supplement 1): 582-83.  
    9. Ipsiroglu OS, Chan F, Vilela-Barbosa A, Black A, Garden J, Veer D, Jan JE, Vatikiotis-Bateson E.: Restless Legs Syndrome (RLS) in Children and Youth with Neurodevelopmental Conditions - a Clinically Missed Diagnosis Aggravating the Challenging Behaviour of Underlying Conditions? Sleep Med. September 2011; 12(Supplement 1): S119.
    10. Hung A, Chan F, Barbosa A, Vatikiotis-Bateson E, Black A, Maurer J, Jan JE, Ipsiroglu OS.: Differentiating restless legs syndrome (RLS) as a cause of circadian rhythm sleep disorders (CRSD): Video studies in the home setting – commercially available low cost equipment [abstract]. Somnology Sleep Research and Sleep Medicine. 2011; 15(1): 79.
    Grants
    • 2013/2014: Peter Wall Institute for Advanced Studies: Visiting Scholar Funding for Dr. Karen Spruyt, Vrije Universiteit, Brussels (together with Dr. Sylvia Stockler)
    • 2012: Peter Wall Institute for Advanced Studies: Phenotyping Sleep Behaviours Lessons from the Past, Directions for the Future (together with Dr. Bruce Carleton) 
    • 2009-2012: Canadian Institute of Health Research. Night waking reduction in Canadian infants: a randomized clinical trial of a parent based cognitive and behavioural  intervention in community health units. (Co-PI, PI: Dr. Wendy Hall)
    • 2008-2012: Victoria Foundation. Fetal alcohol syndrome disorders (FASD) & sleep disturbances: the  burden and interventions. A multidisciplinary approach. (PI, together with Dr. James Jan)
    Honours & Awards
    • 2011: Excellence in Education Award, Learning & Development BC Children's hospital & BC Women's Hospital & Health Care
    • 2008: Transcultural Paediatrics Award, German Society for Socialpaediatrics & Adolescent Medicine and Austrian Society of Paediatrics
    Research Group Members
    • Mai Berger (Co-op student, UBC)
    • Wais Darwish BA
    • Kirsten Graham BA
    • Amy Hung (Student of Medicine, UBC)
    • Les Matthews (Associate Professor, Kamloops, TRU)
    • Kelsey Timler BA (Project Coordinator)
    • Francesca Roth (SFU)
    • Alexandra Wagner (Student of Medicine, University of Salzburg, Austria)
    • Duncan Wong (Co-op student, UBC)