Gabriela Ana Horvath

Investigator, BC Children's Hospital

Neurotransmitters are chemicals synthesized inside the brain cells (neuron). Signals from the neuron travel out a thread-like extension called the axon, which connects to the next brain cell through a gap (synapse). There are the target neurons waiting for the signal.

There are many neurotransmitters in the brain. Serotonin, dopamine, acetylcholine are three of them.

Serotonin's role in the body has been associated mainly with mood, but it has major roles in temperature regulation, pain perception, sleep regulation, gut function (irritable bowel syndrome), major vessel constriction and relaxation, blood pressure control, and even neurodegenerative disorders like ALS have been associated with serotonin.

Dopamine is a neurotransmitter involved in motor function, behaviour, and cognition.

Acetylcholine functions both in the brain and peripheral neurons as a neuromodulator, it regulates gut function, sensory and autonomic nervous system, and sleep.

My major research is to define some of these neurotransmitters' involvement in disease.

Academic Affiliations

  • Clinical Associate Professor, Division of Biochemical Genetics, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Neurodevelopmental and Neurological Disorders; Rare Diseases

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Grants

Dravet Foundation Canada, Drug response on intraneuronal Ca2+ signaling in neuronal IPScells in Dravet syndrome, $25,000 (Aug 2024- Sep 2025)

RDMM Network, Exploring the mechanism of Ca2+ signaling in neuronal IPScells in Dravet syndrome, $30,000 (Mar 2025- Feb 2026)

Dystonia Medical Research Foundation Canada, Validation of a clinical and deep learning-based tool for recognition, assessment, and monitoring of complex movement disorders, $9,000 (Sep 2024-Aug 2025)

BC Children’s Hospital Foundation, Characterization of CSF metabolome in patients with secondary neurotransmitter deficiencies, $10,000 (Aug 2024- Jul 2025)

Honours & Awards

“Excellence in Research Mentorship”, award from the Neurology residents, awarded at the Annual Neurology Resident Research Day, in 2015, 2016, 2017

Clinical Investigator Program, two year scholarship awarded (July 2008 to June 2010)

Laura MacRae Award 2007 (awarded to outstanding graduate student in the Dept. of Pediatrics, UBC, by the College of Physicians and Surgeons of British Columbia, June 2007

Rookie of the Year 2007, (awarded by the Pediatric Residents, UBC, at the Annual Graduation and Awards Dinner), June 2007.

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