Projects

Current projects

2019: Q19-06 Cough and cold products containing opioids: Prescribing and patient utilization patterns in the pediatric population – SEARCH/PREVENT (status: ongoing)

2016: Q16-10 SEARCH – Domperidone and lactation – SEARCH/PREVENT (status: ongoing)

2014: Q14-02c Direct oral anticoagulants for the treatment of venous thromboembolic events –SEARCH/PREVENT (status: ongoing)

2013: Q13-05 Optimizing chronic hepatitis C treatment – SEARCH/PREVENT (status: ongoing)

2010: Q10-11 5-HT3 antagonists and cardiac safety – SEARCH/PREVENT (status: ongoing)

Completed projects

2012: Inhaled corticosteroid use in children and in pregnancy – SEARCH

Smy L; Shaw K; Amstutz U; Staub M; Chaudhry S; Smith A; Carleton B; Koren G. Assessment of Hair Cortisol as a Potential Biomarker for Possible Adrenal Suppression due to Inhaled Corticosteroid Use in Children with Asthma: A Retrospective Observational Study. Clin Biochem. 2018 Jun;56:26-32. PMID: 29673814 10.1016/j.clinbiochem.2018.04.006 Journal Article

Smy L; Shaw K; Amstutz U; Smith A; Berger H; Carleton B; Koren G. Hair cortisol as a hypothalamic-pituitary-adrenal axis biomarker in pregnant women with asthma: a retrospective observational study. BMC Pregnancy Childbirth. 2016 Jul 20;16(1):176. PMID 27440139 10.1186/s12884-016-0962-4 Journal Article

Smy L; Shaw K; Smith A; Evan R; Uum SV; Rieder M; Carleton B; Koren G. Hair cortisol as a novel biomarker of HPA suppression by inhaled corticosteroids in children. Pediatr Res. 2015 Jul;78(1):44-7. PMID: 25790275. 10.1038/pr.2015.60 Journal Article

2013: Pharmacogenomic predictors of statin‐induced myopathy – PREVENT

DeGorter MK, Rommel G Tirona, Schwarz UI, Choi YH, Dresser GK, Suskin N, Myers K, Zou GY, Iwuchukwu O, Wei WQ, Wilke RA, Hegele RA, Kim RB. Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care. Circ Cardiovasc Genet. 2013 Aug;6(4):400-8. PMID: 23876492. 10.1161/CIRCGENETICS.113.000099 Journal Article

2015: Pharmacogenomic markers of anthracycline‐induced heart failure in children – SEARCH

Scott E; Hasbullah JS; Ross CJD; Carleton BC. Reducing anthracycline-induced cardiotoxicity through pharmacogenetics. Pharmacogenomics. 2018 Oct;19(15):1147-1150. PMID: 30213233 10.2217/pgs-2018-0124 Journal Article

Aminkeng F; Ross CJD; Rassekh SR; Hwang S; Rieder MJ; Bhavsar AP; Smith A; Sanatani S; Gelmon KA; Bernstein D; Hayden MR; Amstutz U; Carleton BC; CPNDS Clinical Practice Recommendations Group. Recommendations for Genetic Testing to Reduce the Incidence of Anthracycline-induced Cardiotoxicity. Br J Clin Pharmacol. 2016 Sep;82(3):683-95. PMID: 27197003 10.1111/bcp.13008 Journal Article

Aminkeng F; Bhavsar AP; Visscher H; Rassekh SR; Li Y; Lee JW; Brunham LR; Caron HN; van Dalen EC; Kremer LC; van der Pal HJ; Amstutz U; Rieder MJ; Bernstein D; Carleton BC; Hayden MR; Ross CJD; The Canadian Pharmacogenomics Networks for Drug Safety Consortium. A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer. Nat Genet. 2015 Sep;47(9):1079-84. PMID: 26237429 10.1038/ng.3374 Journal Article

Visscher H; Ross CJD; Rassekh SR; Barhdadi A; Dubé MP; Sandor GS; Caron HN; van Dalen EC; Kremer LC; van der Pal HJ; Brown AMK; Rogers PC; Phillips MS; Rieder MJ; Carleton BC; Hayden MR. Canadian Pharmacogenomics Network for Drug Safety Consortium. Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children. J Clin Oncol. 2012 May;30(1):1422-8. PMID: 21900104 10.1200/JCO.2010.34.3467 Journal Article

Visscher H; Rassekh SR; Sandor GS; Caron HN; van Dalen EC; Kremer LC; van der Pal HJ; Rogers PC; Rieder MJ; Carleton BC; Hayden MR; Ross CJ. The CPNDS Consortium. Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children. Pharmacogenomics. 2015 Jul;16(10):1065-76. PMID: 26230641 10.2217/pgs.15.61 Journal Article

Visscher H; Ross CJD; Rassekh SR; Sandor GS; Caron HN; van Dalen EC; Kremer LC; van der Pal HJ; Rogers PC; Rieder MJ; Carleton BC; Hayden MR. The CPNDS Consortium. Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children. Pediatr Blood Cancer. 2013 Aug;60(8):1375-81. PMID: 23441093 10.1002/pbc.24505 Journal Article

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We believe there’s nothing we can’t do with your support. It can take years to turn scientific breakthrough into new interventions and treatments. Funding helps speed the pace of change. When given the resources, we can bring transformative therapies – and hope – out of the laboratory and into the clinic to save and improve children’s lives.