My clinical research takes place at the Oak Tree Clinic, where a multidisciplinary team provides care to HIV+ women, their partners, and their children, both uninfected and HIV infected. We coordinate a Canadian surveillance program of mother-to-child HIV transmission. In uninfected children born to seropositive mothers, we investigate the potential effects of exposure to anti-HIV drugs during prenatal life on their long term health. In collaboration with a UBC laboratory, we study maternal, placental and infant blood cells for markers of premature aging or mutations.
In children and adolescents living with HIV in BC, we investigate long term effects of HIV infection and the potential effects of medications on bone health and bone acquisition. We participate in multicentre studies, evaluating the response to the HPV vaccine in HIV+ girls and women, or the effectiveness of fish-oil (omega-3) supplements in the treatment of medication-associated high lipids in HIV+ children.
Health Care Provider Utilization and Cost of an mHealth Intervention in Vulnerable People Living With HIV in Vancouver, Canada: Prospective Study
JMIR mHealth and uHealth
Blood Mitochondrial DNA Content in HIV-Exposed Uninfected Children with Autism Spectrum Disorder
Matthew Budd and Kristina Calli and Lindy Samson and Jennifer Bowes and Anthony Hsieh and John Forbes and Ari Bitnun and Joel Singer and Fatima Kakkar and Ariane Alimenti and Evelyn Maan and M. Lewis and Carole Gentile and Hélène Côté and Jason Brophy
Mobile Text Messaging to Improve Medication Adherence and Viral Load in a Vulnerable Canadian Population Living With Human Immunodeficiency Virus: A Repeated Measures Study
Journal of Medical Internet Research
Elizabeth King and Karen Kinvig and Jonathan Steif and Annie Q Qiu and Evelyn J Maan and Arianne YK Albert and Neora Pick and Ariane Alimenti and Mary H Kestler and Deborah M Money and Richard T Lester and Melanie Caroline Margaret Murray
Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living with HIV
The Pediatric Infectious Disease Journal
Jason Brophy and Ari Bitnun and Ariane Alimenti and Normand Lapointe and Lindy Samson and Stanley Read and Christos Karatzios and Simon Dobson and Erin Moses and Sandra Blitz and Nancy-Grace Lipsky and Gina Ogilvie and Sharon Walmsley and Janet Raboud and Deborah Money
Leukocyte Telomere Length at Birth and During the Early Life of Children Exposed to but Uninfected With HIV After In Utero Exposure to Antiretrovirals
The Journal of Infectious Diseases
Abhinav Ajaykumar and Hugo Soudeyns and Fatima Kakkar and Jason Brophy and Ari Bitnun and Ariane Alimenti and Arianne Y K Albert and Deborah M Money and Hélène C F Côté and Neora Pick and Melanie Murray and Patricia Janssen and Joel Singer and Normand Lapointe and Jerilynn Prior and Michael Silverman and Mary Lou Smith and CIHR Team in Cellular Aging and HIV Comorbidities in Women and Children
HIV viral suppression results in higher antibody responses in HIV-positive women vaccinated with the quadrivalent human papillomavirus vaccine
Deborah M. Money and Erin Moses and Sandra Blitz and Shannon M. Vandriel and Nancy Lipsky and Sharon L. Walmsley and Mona Loutfy and Sylvie Trottier and Fiona Smaill and Mark H. Yudin and Marina Klein and Marianne Harris and Jeffrey Cohen and Wendy Wobeser and Ari Bitnun and Normand Lapointe and Lindy Samson and Jason Brophy and Christos Karatzios and Gina Ogilvie and François Coutlée and Janet Raboud and Ariane Alimenti and Simon Dobson and Catherine Hankins and Janet Hill and Mel Krajden and Jessica McAlpine and Neora Pick and Joel Singer and Sarah Stone and Marcie Summers and Darrell Tan and Laura Vicol and Julie van Schalkwyk
Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary
Journal of Obstetrics and Gynaecology Canada
Deborah Money and Karen Tulloch and Isabelle Boucoiran and Sheila Caddy and Mark H. Yudin and Victoria Allen and Celine Bouchard and Marc Boucher and Isabelle Boucoiran and Sheila Caddy and Eliana Castillo and Heather Gottlieb and V. Logan Kennedy and Deborah Money and Kellie Murphy and Gina Ogilvie and Caroline Paquet and Julie van Schalkwyk and Ariane Alimenti and Neora Pick
Prevention of Vertical HIV Transmission and Management of the HIV-Exposed Infant in Canada in 2014
Canadian Journal of Infectious Diseases and Medical Microbiology
Ari Bitnun and Jason Brophy and Lindy Samson and Ariane Alimenti and Fatima Kakkar and Valerie Lamarre and Dorothy Moore and Christos Karatzios and Sandra Seigel and Laura Sauve and Wendy Vaudry and Mark H Yudin and Deborah Money
Leukocyte Telomere Length in HIV-Infected Pregnant Women Treated With Antiretroviral Drugs During Pregnancy and Their Uninfected Infants
JAIDS Journal of Acquired Immune Deficiency Syndromes
Tuhina Imam and Marissa H. J. Jitratkosol and Hugo Soudeyns and Beheroze Sattha and Izabelle Gadawski and Evelyn Maan and John C. Forbes and Ariane Alimenti and Normand Lapointe and Valerie Lamarre and Deborah M. Money and Hélène C. F. Côté
Leukocyte Telomere Length in HIV-Infected and HIV-Exposed Uninfected Children: Shorter Telomeres with Uncontrolled HIV Viremia
Hélène C. F. Côté and Hugo Soudeyns and Anona Thorne and Ariane Alimenti and Valérie Lamarre and Evelyn J. Maan and Beheroze Sattha and Joel Singer and Normand Lapointe and Deborah M. Money and John Forbes and the CIHR Emerging Team in HIV therapy and aging (CARMA)
A national review of vertical HIV transmission
John C. Forbes and Ariane M. Alimenti and Joel Singer and Jason C. Brophy and Ari Bitnun and Lindy M. Samson and Deborah M. Money and Terry C.K. Lee and Normand D. Lapointe and Stanley E. Read
Blood mitochondrial DNA mutations in HIV-infected women and their infants exposed to HAART during pregnancy
Marissa H.J. Jitratkosol and Beheroze Sattha and Evelyn J. Maan and Izabelle Gadawski and P. Richard Harrigan and John C. Forbes and Ariane Alimenti and Julie van Schalkwyk and Deborah M. Money and Hélène C.F. Côté
Somatic AgC/TgG mitochondrial DNA mutations in HIV-infected pregnant women and their infants exposed to HIV antiretroviral therapy during pregnancy
Marissa Jitratkosol and Beheroze Sattha and Izabelle Gadawski and Evelyn Maan and R. Richard Harrigan and Ariane Alimenti and John Forbes and Deborah Money and Hélène C.F. Côté¿
Evaluation of an Emergency Prevention Program for Mother to Child Transmission of HIV in British Columbia
Journal of Obstetrics and Gynaecology Canada
Sarah J. Saunders and Laura E. Weingarten and Evelyn Maan and Tessa Chaworth-Musters and John C. Forbes and Ariane Alimenti and Jill Mahy and David R. Burdge and Julie van Schalkwyk and Gloria Tsang and Carlo Quaia and Robert S. Hogg and Deborah M. Money
Perinatal Exposure to Antiretroviral Therapy Is Associated with Increased Blood Mitochondrial DNA Levels and Decreased Mitochondrial Gene Expression in Infants
The Journal of Infectious Diseases
Hélène C. F. Côté and Janet Raboud and Ari Bitnun and Ariane Alimenti and Deborah M. Money and Evelyn Maan and Adriana Costei and Izabelle Gadawski and Christina Diong and Stanley Read and Sandy Shen and P. Richard Harrigan and David R. Burdge and Susan M. King and John C. Forbes
Growing up: Perspectives of children, families and service providers regarding the needs of older children with perinatally-acquired HIV
S. J. Fielden and L. Sheckter and G. E. Chapman and A. Alimenti and J. C. Forbes and S. Sheps and S. Cadell and J. C. Frankish
A Prospective Controlled Study of Neurodevelopment in HIV-Uninfected Children Exposed to Combination Antiretroviral Drugs in Pregnancy
A. Alimenti and J. C. Forbes and T. F. Oberlander and D. M. Money and R. E. Grunau and M. P. Papsdorf and E. Maan and L. J. Cole and D. R. Burdge
Lactic acidemia in human immunodeficiency virus-uninfected infants exposed to perinatal antiretroviral therapy
The Pediatric Infectious Disease Journal
ARIANE ALIMENTI and DAVID R. BURDGE and GINA S. OGILVIE and DEBORAH M. MONEY and JOHN C. FORBES
Cardiac and autonomic evaluation in a pediatric population with human immunodeficiency virus
D. Plein and G. Van Camp and B. Cosyns and A. Alimenti and J. Levy and J.-L. Vandenbossche
Detection of virus in vertically exposed HIV-antibody-negative children
M-L Newell and D Dunn and C Peckham and A De Maria and A Ferrazin and A De Rossi and C Giaquinto and J Levy and A Alimenti and A Ehrnst and A-B Bohlin and R Ljung
Quantitation of HIV-1 in whole blood of infected children
Ariane Alimenti and Katherine Luzuriaga and John L. Sullivan and Chantal Van den Borre and Georges Zissis and Jack Levy
Diagnosis of Vertical Human Immunodeficiency Virus Type 1 Infection byWhole Blood Culture
Journal of Infectious Diseases
A. Alimenti and M. O'Neill and J. L. Sullivan and K. Luzuriaga
LONG TERM HEALTH OUTCOMES OF HIV UNINFECTED CHILDREN BORN TO HIV INFECTED MOTHERS
This study explores the accessibility of the BC cohort and examines the longer term health outcomes of HIV negative children exposed to antiretroviral therapy perinatally using a health questionnaire and by contact with their past or current health care professionals.
At the end of this pilot project, based on study outcomes, we will develop and implement a comprehensive and outcome oriented study exploring:
• the incidence of poor health outcomes such as growth abnormalities, susceptibility to infection, admissions to hospital, significant developmental disorders, poor scholastic performance, interaction with law enforcement, etc. in ARV exposed children compared to a age, sex and socio-economic status (parental education, household income and first 3 digits of postal code) matched control population;
• the association between length and type of ARV exposure and specific poor health outcomes;
• a comparison with the health outcomes of uninfected ARV exposed children from BC and three other pediatric HIV referral centres in Canada.
We hypothesize that, compared to all British Columbian children, HIV-uninfected, ARV exposed children will have a higher frequency of poor health outcomes such as described above. Enrolment is 95% complete. This pilot of British Columbia HIV/ARV exposed children is largely hypothesis generating and will guide the development of a larger multi-centred project.
CANADIAN PERINATAL HIV SURVEILLANCE PROGRAM (CPHSP)
in collaboration with the Canadian HIV Trials Network (CTN) and Public Health Agency of Canada (PHAC).
This web-based database collects data from 21 pediatric sites covering all Canadian provinces and territories. The program generates descriptive data annually on:
A. HIV exposed children:
• the number of infants born to HIV positive women in Canada
• demographic, geographic and risk factor parameters of mother-infant pairs
• the use of antiretroviral therapy (ART) in pregnancy (proportion of HIV+ pregnant women receiving ART, type and duration of ART in mother and infant)
• the rate of mother-to-child HIV transmission
• infant outcomes (mortality)
B. HIV infected children:
•the number of known perinatally infected infants and children followed at the centres
•annual update on their clinical status, immune status and mortality
IS THE BONE HEALTH OF HIV INFECTED CHILDREN AND ADOLESCENTS COMPROMISED?
A substudy of CARMA, the CIHR emerging team grant "Mechanism of aging following exposure to HIV antiretroviral drugs."
Both HIV and the antiretrovirals are suspected to affect the acquisition of bone mass, raising concerns about bone strength and fracture risk.
We have completed year 1 of this 3-year longitudinal study involving HIV infected children in BC (approximately 30). The objectives are to:
a. Determine whether HIV infected children have low bone mass compared to a healthy local population, using DXA (Dual-Energy X-ray Absorptiometry)
b. Assess bone strength using pQCT (peripheral quantitative computed tomography, a novel scanning technology
c. Determine the role of calcium and vitamin D intake, physical activity, muscle power, severity of disease and HIV medications on bone mass and bone strength.
Results are compared to an existing group of healthy BC children.
This study will set the basis for a multicentre study and for clinical guidelines for assessment and intervention.