Overview

My clinical research takes place at the Oak Tree Clinic, where a multidisciplinary team provides care to HIV+ women, their partners, and their children, both uninfected and HIV infected. We coordinate a Canadian surveillance program of mother-to-child HIV transmission. In uninfected children born to seropositive mothers, we investigate the potential effects of exposure to anti-HIV drugs during prenatal life on their long term health. In collaboration with a UBC laboratory, we study maternal, placental and infant blood cells for markers of premature aging or mutations.

In children and adolescents living with HIV in BC, we investigate long term effects of HIV infection and the potential effects of medications on bone health and bone acquisition. We participate in multicentre studies, evaluating the response to the HPV vaccine in HIV+ girls and women, or the effectiveness of fish-oil (omega-3) supplements in the treatment of medication-associated high lipids in HIV+ children.

Publications

Challenges to achieving and maintaining viral suppression among children living with HIV
AIDS (London, England)
Kakkar, F. and Lee, T. and Hawkes, M.T. and Brophy, J. and Lindy, S. and Singer, J. and Dieumegard, H. and Sauve, L. and Alimenti, A. and Vaudry, W. and Seigel, S. and Tan, B. and Karatzios, C. and Lamarre, V. and Read, S. and Soudeyns, H. and Bitnun, A.
DOI: 10.1097/QAD.0000000000002454
2020

Clinical correlates of human immunodeficiency virus-1 (HIV-1) DNA and inducible HIV-1 RNA reservoirs in peripheral blood in children with perinatally acquired HIV-1 infection with sustained virologic suppression for at least 5 years
Clinical Infectious Diseases
Bitnun, A. and Ransy, D.G. and Brophy, J. and Kakkar, F. and Hawkes, M. and Samson, L. and Annabi, B. and Pagliuzza, A. and Morand, J.-A. and Sauve, L. and Chomont, N. and Lavoie, S. and Kim, J. and Sandstrom, P. and Wender, P.A. and Lee, T. and Singer, J. and Read, S.E. and Soudeyns, H. and Alimenti, A. and Ancuta, P. and Bullard, J. and Chun, T.-W. and C{\^o}t{\'e}, H.C.F. and Embree, J. and Hawkes, M.T. and Karatzios, C. and Kaul, R. and Lamarre, V. and Lapointe, N. and Lavoie, P. and Money, D.M. and Moore, D. and Read, S. and Reinhard, R. and Sandstorm, P. and Seigel, S. and Tan, B. and Vaudry, W.
DOI: 10.1093/cid/ciz251
2020

Transition from Pediatric to Adult HIV Care for Young Women Living with HIV
Journal of the International Association of Providers of AIDS Care
Kennedy, V.L. and Mellor, K.L. and Brophy, J. and Bitnun, A. and Alimenti, A. and Kakkar, F. and Logie, C.H. and Webster, K. and Proulx-Boucher, K. and Ding, E. and Jabbari, S. and Kaida, A. and de Pokomandy, A. and Loutfy, M.
DOI: 10.1177/2325958220903574
2020

Investigation of factors associated with spontaneous preterm birth in pregnant women living with HIV
AIDS (London, England)
Albert, A.Y.K. and Elwood, C. and Wagner, E.C. and Pakzad, Z. and Chaworth-Musters, T. and Berg, K. and Van Schalkwyk, J. and Maan, E.J. and Azampanah, A. and McClymont, E. and Alimenti, A. and Forbes, J.C. and Money, D.M.
DOI: 10.1097/QAD.0000000000002464
2020

Exploring the live birth rates of women living with HIV in British Columbia, Canada
PLOS ONE
DOI: 10.1371/journal.pone.0211434
02/2019

Congenital anomalies following antenatal exposure to dolutegravir: a Canadian surveillance study
BJOG: An International Journal of Obstetrics and Gynaecology
Money, D. and Lee, T. and O{'}Brien, C. and Brophy, J. and Bitnun, A. and Kakkar, F. and Boucoiran, I. and Alimenti, A. and Vaudry, W. and Singer, J. and Sauve, L.J.
DOI: 10.1111/1471-0528.15838
2019

Neurodevelopmental outcomes and in utero antiretroviral exposure in HIV-exposed uninfected children
AIDS
DOI: 10.1097/qad.0000000000001985
08/2018

Health Care Provider Utilization and Cost of an mHealth Intervention in Vulnerable People Living With HIV in Vancouver, Canada: Prospective Study
JMIR mHealth and uHealth
DOI: 10.2196/mhealth.9493
07/2018

Blood Mitochondrial DNA Content in HIV-Exposed Uninfected Children with Autism Spectrum Disorder
Viruses
Matthew Budd and Kristina Calli and Lindy Samson and Jennifer Bowes and Anthony Hsieh and John Forbes and Ari Bitnun and Joel Singer and Fatima Kakkar and Ariane Alimenti and Evelyn Maan and M. Lewis and Carole Gentile and Hélène Côté and Jason Brophy
DOI: 10.3390/v10020077
02/2018

Neurodevelopmental outcomes and in-utero antiretroviral exposure in HIV-exposed uninfected children
AIDS (London, England)
Piske, M. and Budd, M.A. and Qiu, A.Q. and Maan, E.J. and Sauv{\'e}, L.J. and Forbes, J.C. and Alimenti, A. and Janssen, P. and C{\^o}t{\'e}, H.C.F.
DOI: 10.1097/QAD.0000000000001985
2018

Leukocyte telomere length at birth and during the early life of children exposed to but uninfected with HIV after in utero exposure to antiretrovirals
Journal of Infectious Diseases
Ajaykumar, A. and Soudeyns, H. and Kakkar, F. and Brophy, J. and Bitnun, A. and Alimenti, A. and Albert, A.Y.K. and Money, D.M. and C{\^o}t{\'e}, H.C.F. and Pick, N. and Murray, M. and Janssen, P. and Singer, J. and Lapointe, N. and Prior, J. and Silverman, M. and Smith, M.L.
DOI: 10.1093/infdis/jix618
2018

Immunogenicity and safety of the quadrivalent human papillomavirus vaccine in girls living with HIV
Pediatric Infectious Disease Journal
Brophy, J. and Bitnun, A. and Alimenti, A. and Lapointe, N. and Samson, L. and Read, S. and Karatzios, C. and Dobson, S. and Moses, E. and Blitz, S. and Lipsky, N.-G. and Ogilvie, G. and Walmsley, S. and Raboud, J. and Money, D. and Azampanah, A. and Cohen, J. and Coutl{\'e}e, F. and Hankins, C. and Harris, M. and Kaida, A. and Klein, M. and Krajden, M. and Loutfy, M. and McAlpine, J. and Pick, N. and Seigel, S. and Singer, J. and Smaill, F. and Stone, S. and Summers, M. and Trottier, S. and Van Niekirk, D. and Van Schalkwyk, J. and Kakkar, F. and Vicol, L. and Watt, M. and Wobeser, W. and Yudin, M.H.
DOI: 10.1097/INF.0000000000001874
2018

Mobile Text Messaging to Improve Medication Adherence and Viral Load in a Vulnerable Canadian Population Living With Human Immunodeficiency Virus: A Repeated Measures Study
Journal of Medical Internet Research
Elizabeth King and Karen Kinvig and Jonathan Steif and Annie Q Qiu and Evelyn J Maan and Arianne YK Albert and Neora Pick and Ariane Alimenti and Mary H Kestler and Deborah M Money and Richard T Lester and Melanie Caroline Margaret Murray
DOI: 10.2196/jmir.6631
06/2017

Muscle power in children, youth and young adults who acquired HIV perinatally.
Journal of musculoskeletal & neuronal interactions
PubMed: 28574409
06/2017

Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living with HIV
The Pediatric Infectious Disease Journal
Jason Brophy and Ari Bitnun and Ariane Alimenti and Normand Lapointe and Lindy Samson and Stanley Read and Christos Karatzios and Simon Dobson and Erin Moses and Sandra Blitz and Nancy-Grace Lipsky and Gina Ogilvie and Sharon Walmsley and Janet Raboud and Deborah Money
DOI: 10.1097/inf.0000000000001874
2017

Muscle power in children, youth and young adults who acquired HIV perinatally
Journal of Musculoskeletal Neuronal Interactions
Macdonald, H.M. and Nettlefold, L. and Maan, E.J. and C{\^o}t{\'e}, H. and Alimenti, A.
2017

HIV viral suppression results in higher antibody responses in HIV-positive women vaccinated with the quadrivalent human papillomavirus vaccine
Vaccine
Deborah M. Money and Erin Moses and Sandra Blitz and Shannon M. Vandriel and Nancy Lipsky and Sharon L. Walmsley and Mona Loutfy and Sylvie Trottier and Fiona Smaill and Mark H. Yudin and Marina Klein and Marianne Harris and Jeffrey Cohen and Wendy Wobeser and Ari Bitnun and Normand Lapointe and Lindy Samson and Jason Brophy and Christos Karatzios and Gina Ogilvie and François Coutlée and Janet Raboud and Ariane Alimenti and Simon Dobson and Catherine Hankins and Janet Hill and Mel Krajden and Jessica McAlpine and Neora Pick and Joel Singer and Sarah Stone and Marcie Summers and Darrell Tan and Laura Vicol and Julie van Schalkwyk
DOI: 10.1016/j.vaccine.2016.08.016
09/2016

Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary
Journal of Obstetrics and Gynaecology Canada
Deborah Money and Karen Tulloch and Isabelle Boucoiran and Sheila Caddy and Mark H. Yudin and Victoria Allen and Celine Bouchard and Marc Boucher and Isabelle Boucoiran and Sheila Caddy and Eliana Castillo and Heather Gottlieb and V. Logan Kennedy and Deborah Money and Kellie Murphy and Gina Ogilvie and Caroline Paquet and Julie van Schalkwyk and Ariane Alimenti and Neora Pick
DOI: 10.1016/s1701-2163(15)30515-6
08/2014

Prevention of Vertical HIV Transmission and Management of the HIV-Exposed Infant in Canada in 2014
Canadian Journal of Infectious Diseases and Medical Microbiology
Ari Bitnun and Jason Brophy and Lindy Samson and Ariane Alimenti and Fatima Kakkar and Valerie Lamarre and Dorothy Moore and Christos Karatzios and Sandra Seigel and Laura Sauve and Wendy Vaudry and Mark H Yudin and Deborah Money
DOI: 10.1155/2014/526019
2014

Guidelines for the care of pregnant women living with HIV and interventions to reduce perinatal transmission: Executive summary,Lignes directrices pour ce qui est des soins à offrir aux femmes enceintes qui vivent avec le VIH et des interventions visant à atténuer la transmission périnatale : Résumé directif
Journal of Obstetrics and Gynaecology Canada
Money, D. and Tulloch, K. and Boucoiran, I. and Caddy, S. and Yudin, M.H. and Allen, V. and Bouchard, C. and Boucher, M. and Castillo, E. and Gottlieb, H. and Kennedy, V.L. and Murphy, K. and Ogilvie, G. and Paquet, C. and van Schalkwyk, J. and Alimenti, A. and Pick, N.
DOI: 10.1016/S1701-2163(15)30516-8
2014

Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary
Journal of Obstetrics and Gynaecology Canada
Money, D. and Tulloch, K. and Boucoiran, I. and Caddy, S. and Yudin, M.H. and Allen, V. and Bouchard, C. and Boucher, M. and Castillo, E. and Gottlieb, H. and Kennedy, V.L. and Murphy, K. and Ogilvie, G. and Paquet, C. and van Schalkwyk, J. and Alimenti, A. and Pick, N.
DOI: 10.1016/S1701-2163(15)30515-6
2014

Prevention of vertical HIV transmission and management of the HIV-exposed infant in Canada in 2014
Canadian Journal of Infectious Diseases and Medical Microbiology
Bitnun, A. and Brophy, J. and Samson, L. and Alimenti, A. and Kakkar, F. and Lamarre, V. and Moore, D. and Karatzios, C. and Seigel, S. and Sauve, L. and Vaudry, W. and Yudin, M. and Money, D.
2014

Bone geometry and strength are adapted to muscle force in children and adolescents perinatally infected with HIV
Journal of Musculoskeletal Neuronal Interactions
Macdonald, H. and Chu, J. and Nettlefold, L. and Maan, E.J. and Forbes, J.C. and C{\^o}t{\'e}, H. and Alimenti, A.
2013

Leukocyte Telomere Length in HIV-Infected Pregnant Women Treated With Antiretroviral Drugs During Pregnancy and Their Uninfected Infants
JAIDS Journal of Acquired Immune Deficiency Syndromes
Tuhina Imam and Marissa H. J. Jitratkosol and Hugo Soudeyns and Beheroze Sattha and Izabelle Gadawski and Evelyn Maan and John C. Forbes and Ariane Alimenti and Normand Lapointe and Valerie Lamarre and Deborah M. Money and Hélène C. F. Côté
DOI: 10.1097/qai.0b013e31825aa89c
08/2012

Leukocyte Telomere Length in HIV-Infected and HIV-Exposed Uninfected Children: Shorter Telomeres with Uncontrolled HIV Viremia
PLoS ONE
Hélène C. F. Côté and Hugo Soudeyns and Anona Thorne and Ariane Alimenti and Valérie Lamarre and Evelyn J. Maan and Beheroze Sattha and Joel Singer and Normand Lapointe and Deborah M. Money and John Forbes and the CIHR Emerging Team in HIV therapy and aging (CARMA)
DOI: 10.1371/journal.pone.0039266
07/2012

A national review of vertical HIV transmission
AIDS
John C. Forbes and Ariane M. Alimenti and Joel Singer and Jason C. Brophy and Ari Bitnun and Lindy M. Samson and Deborah M. Money and Terry C.K. Lee and Normand D. Lapointe and Stanley E. Read
DOI: 10.1097/qad.0b013e328350995c
03/2012

Blood mitochondrial DNA mutations in HIV-infected women and their infants exposed to HAART during pregnancy
AIDS
Marissa H.J. Jitratkosol and Beheroze Sattha and Evelyn J. Maan and Izabelle Gadawski and P. Richard Harrigan and John C. Forbes and Ariane Alimenti and Julie van Schalkwyk and Deborah M. Money and Hélène C.F. Côté
DOI: 10.1097/qad.0b013e32835142eb
03/2012

Leukocyte telomere length in HIV-infected pregnant women treated with antiretroviral drugs during pregnancy and their uninfected infants
Journal of Acquired Immune Deficiency Syndromes
Imam, T. and Jitratkosol, M.H.J. and Soudeyns, H. and Sattha, B. and Gadawski, I. and Maan, E. and Forbes, J.C. and Alimenti, A. and Lapointe, N. and Lamarre, V. and Money, D.M. and C{\^o}t{\'e}, H.C.F.
DOI: 10.1097/QAI.0b013e31825aa89c
2012

Blood mitochondrial DNA mutations in HIV-infected women and their infants exposed to HAART during pregnancy
AIDS
Jitratkosol, M.H.J. and Sattha, B. and Maan, E.J. and Gadawski, I. and Harrigan, P.R. and Forbes, J.C. and Alimenti, A. and Van Schalkwyk, J. and Money, D.M. and C{\^o}t{\'e}, H.C.F.
DOI: 10.1097/QAD.0b013e32835142eb
2012

A national review of vertical HIV transmission
AIDS
Forbes, J.C. and Alimenti, A.M. and Singer, J. and Brophy, J.C. and Bitnun, A. and Samson, L.M. and Money, D.M. and Lee, T.C.K. and Lapointe, N.D. and Read, S.E.
DOI: 10.1097/QAD.0b013e328350995c
2012

Somatic AgC/TgG mitochondrial DNA mutations in HIV-infected pregnant women and their infants exposed to HIV antiretroviral therapy during pregnancy
Mitochondrion
Marissa Jitratkosol and Beheroze Sattha and Izabelle Gadawski and Evelyn Maan and R. Richard Harrigan and Ariane Alimenti and John Forbes and Deborah Money and Hélène C.F. Côté¿
DOI: 10.1016/j.mito.2011.03.080
07/2011

Evaluation of an Emergency Prevention Program for Mother to Child Transmission of HIV in British Columbia
Journal of Obstetrics and Gynaecology Canada
Sarah J. Saunders and Laura E. Weingarten and Evelyn Maan and Tessa Chaworth-Musters and John C. Forbes and Ariane Alimenti and Jill Mahy and David R. Burdge and Julie van Schalkwyk and Gloria Tsang and Carlo Quaia and Robert S. Hogg and Deborah M. Money
DOI: 10.1016/s1701-2163(16)34851-4
04/2011

Evaluation of an Emergency Prevention Program for Mother to Child Transmission of HIV in British Columbia
Journal of Obstetrics and Gynaecology Canada
Saunders, S.J. and Weingarten, L.E. and Maan, E. and Chaworth-Musters, T. and Forbes, J.C. and Alimenti, A. and Mahy, J. and Burdge, D.R. and van Schalkwyk, J. and Tsang, G. and Quaia, C. and Hogg, R.S. and Money, D.M.
DOI: 10.1016/S1701-2163(16)34851-4
2011

Perinatal Exposure to Antiretroviral Therapy Is Associated with Increased Blood Mitochondrial DNA Levels and Decreased Mitochondrial Gene Expression in Infants
The Journal of Infectious Diseases
Hélène C. F. Côté and Janet Raboud and Ari Bitnun and Ariane Alimenti and Deborah M. Money and Evelyn Maan and Adriana Costei and Izabelle Gadawski and Christina Diong and Stanley Read and Sandy Shen and P. Richard Harrigan and David R. Burdge and Susan M. King and John C. Forbes
DOI: 10.1086/591253
09/2008

Plasma drug concentrations and virologic evaluations after stopping treatment with nonnucleoside reverse-transcriptase inhibitors in HIV type 1-infected children
Clinical Infectious Diseases
Cressey, T.R. and Green, H. and Khoo, S. and Treluyer, J.-M. and Compagnucci, A. and Saidi, Y. and Lallemant, M. and Gibb, D.M. and Burger, D.M. and Aboulker, J.-P. and Babiker, A. and Blanche, S. and Bohlin, A.-B. and Butler, K. and Castelli-Gattinara, G. and Clayden, P. and Darbyshire, J.H. and Debr{\'e}, M. and de Groot, R. and della Negra, M. and Duicelescu, D. and Giaquinto, C. and Grosch-W{\"o}rner, I. and Kind, C. and Levy, J. and Lyall, H. and Marczynska, M. and Mellado Pe{\~n}a, M.J. and Nadal, D. and Niehues, T. and Peckham, C. and Ramos Amador, J.T. and Rosado, L. and Rudin, C. and Scherpbier, H.J. and Sharland, M. and Stevanovic, M. and Tovo, P.A. and Tudor-Williams, G. and Valerius, N. and Walker, A.S. and Wintergerst, U. and Harper, L. and Klein, N. and Mofenson, L. and Moye, J. and Sa{\"i}di, Y. and Jacqz-Aigrain, E. and Tr{\'e}luyer, J.M. and Clerici, M. and De Rossi, A. and Ngo-Giang-huong, N. and Mu{\~n}oz Fernandez, M.A. and Pillay, D. and Hill, C. and Lepage, P. and Pozniak, A. and Vella, S. and Eliette, V. and Hadjou, G. and L{\'e}onardo, S. and Pitrou, C. and Riault, Y. and Buck, L. and Farrelly, L. and Johnson, D. and Taylor, C. and Chalermpantmetagul, S. and Peongjakta, R. and Chailert, S. and Fregonese, F. and Jourdain, G. and Butler, D. and Carlton, C. and Collins, D. and Kao, G. and Van Buskirk, S. and Watson, S. and Corradini, S. and Floret, D. and Laplace, J. and Monpoux, F. and Cottalorda, J. and Lefebvre, J.C. and Mellul, S. and Boudjoudi, N. and Firtion, G. and Faye, A. and Beniken, D. and Damond, F. and Tricoire, J. and Krivine, A. and Chaix, M.L. and Winter-Gerst, U. and Notheis, G. and Strotmann, G. and Schlieben, S. and Rampon, O. and Zanchetta, M. and Rosso, R. and Repeto, E. and Vitale, F. and Martino, A. and Bernardi, S. and Mazza, A. and Rossetti, G. and Dobosz, S. and Oldakowska, A. and Popielska, J. and Kaflik, M. and Stanczak, J. and Stanczac, T. and Dyda, T. and Gonz{\'a}lez Tom{\'e}, M.I. and Delgado Garc{\'i}a, R. and Jos{\'e} Mellado Pe{\~n}a, M. and Mart{\'i}n-Fontelos, P. and Pi{\~n}eiro P{\'e}rez, R. and Alimenti, A. and Penin, M. and Gurbindo, D. and Navarro Gomez, M.L. and Jimenez, J.L. and Prieto, C. and Mu{\~n}oz-Fernandez, M.A. and de Jos{\'e} G{\'o}mez, M.I. and Garc{\'i}a Rodriguez, M.C. and Moreno P{\'e}rez, D. and N{\'u}{\~n}ez Cuadros, E. and Asensi-Botet, F. and P{\'e}rez, A. and P{\'e}rez Tamarit, M.D. and Kalhert, C. and Schupbach, J. and Bunupuradah, T. and Ananworanich, J. and Phanuphak, P. and Intasan, J. and Ubolyam, S. and Kanjanavanit, S. and Namwong, T. and Foster, C. and Hamadache, D. and Campbell, S. and Hanley, C. and Walsh, C. and Kaye, S. and Seery, P. and Novelli, V. and Shingadia, D. and Flynn, J. and Clapson, M. and Jacobsen, M. and McMaster, P. and Hawkes, E. and Liebeschuetz, S. and Sodeinde, O. and Wong, S. and Walsh, S. and Heath, Y. and Weiner, L. and Famiglietti, M. and Rana, S. and Yu, P. and Roa, J. and Puga, A. and Haerry, A. and Regazzi, M. and Villani, S. and Gibbons, S. and Jullien, V. and Rey, E. and Treluyer, J.M. and Rodr{\'i}guez N{\'o}voa, S. and Tawon, Y.
DOI: 10.1086/587657
2008

Serious toxicity associated with continuous nevirapine-based HAART in pregnancy
BJOG: An International Journal of Obstetrics and Gynaecology
Van Schalkwyk, J.E. and Alimenti, A. and Khoo, D. and Maan, E. and Forbes, J.C. and Burdge, D.R. and Gilgoff, S. and Money, D.M.
DOI: 10.1111/j.1471-0528.2008.01820.x
2008

Growing up: Perspectives of children, families and service providers regarding the needs of older children with perinatally-acquired HIV
AIDS Care
S. J. Fielden and L. Sheckter and G. E. Chapman and A. Alimenti and J. C. Forbes and S. Sheps and S. Cadell and J. C. Frankish
DOI: 10.1080/09540120600581460
11/2006

A Prospective Controlled Study of Neurodevelopment in HIV-Uninfected Children Exposed to Combination Antiretroviral Drugs in Pregnancy
PEDIATRICS
A. Alimenti and J. C. Forbes and T. F. Oberlander and D. M. Money and R. E. Grunau and M. P. Papsdorf and E. Maan and L. J. Cole and D. R. Burdge
DOI: 10.1542/peds.2006-0525
10/2006

Lactic acidemia in human immunodeficiency virus-uninfected infants exposed to perinatal antiretroviral therapy
The Pediatric Infectious Disease Journal
ARIANE ALIMENTI and DAVID R. BURDGE and GINA S. OGILVIE and DEBORAH M. MONEY and JOHN C. FORBES
DOI: 10.1097/01.inf.0000086400.93257.74
09/2003

Cardiac and autonomic evaluation in a pediatric population with human immunodeficiency virus
Clinical Cardiology
D. Plein and G. Van Camp and B. Cosyns and A. Alimenti and J. Levy and J.-L. Vandenbossche
DOI: 10.1002/clc.4960220112
01/1999

The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1: A meta-analysis of 15 prospective cohort studies
New England Journal of Medicine
Andiman, W. and Boucher, M. and Burns, D. and Bryson, Y. and Farley, J. and Fowler, M. and Gabiano, C. and Galli, L. and Hutto, C. and Kind, C. and Korber, B. and Kovacs, A. and Krogstad, P. and Landesman, S. and Lapointe, N. and Lemay, M. and Lew, J. and Mandelbrot, L. and Mayaux, M.J. and Mellins, R. and Minkoff, H. and Mofenson, L. and Nielsen, K. and Newell, M.-L. and Pardi, G. and Peavy, H. and Peckham, C. and Read, J. and Rother, C. and Rudin, C. and Scott, G. and Semprini, A. and Shearer, W. and Simonds, R. and Simpson, B. and Stek, A. and Tovo, P.-A. and Tuomala, R. and Van Dyke, R. and Weedon, J. and de Martino, M. and Harris, D. and Lindsay, M. and Belair, S. and Chan, L. and Kalish, L. and Muenz, L. and Nugent, R. and Schluchter, M. and Durako, S. and Goodwin, S. and Mitchell, R. and Nourjah, P. and Owen, W. and Widmayer, S. and Bardeguez, A. and Hanson, C. and Wiznia, A. and Luzuriaga, K. and Viscarello, R. and Ho, D. and Koup, R. and Chen, I. and Mullins, J. and Wolinsky, S. and Walker, B. and Ammann, A. and Clapp, S. and McDonald, D. and Fauvel, M. and Hankins, C. and Samson, J. and Bailey, A. and Giaquinto, C. and Ruga, E. and De Rossi, A. and Truscia, D. and Grosch-W{\"o}rner, I. and Sch{\"a}fer, A. and Mok, J. and Johnstone, F. and Jiminez, J. and de Alba, C. and Garcia-Rodriguez, M. and Bates, I. and de Jos{\'e}, I. and Hawkins, F. and Martinez Zapico, R. and Asensi-Botet, F. and Otero, M. and P{\'e}rez-Tamarit, D. and Moya, A. and Galbis, M. and Scherpbier, H. and Boer, K. and Bohlin, A. and Lindgren, S. and Ehrnst, A. and Anz{\'e}n, B. and Belfrage, E. and Levy, J. and Alimenti, A. and Barlow, P. and Ferrazin, A. and De Maria, A. and Gotta, C. and Maritati, V. and M{\^u}r, A. and Rovira, M. and Paya, A. and Coll, O. and Fortuny, C. and Bogu{\~n}a, J. and Casellas Caro, M. and Canet, Y. and Ravizza, M. and Castagna, C. and Fiore, S. and Guerra, B. and Lanari, M. and Bianchi, S. and Bovicelli, L. and Prati, E. and Zanelli, S. and Duse, M. and Soresina, A. and Scaravelli, G. and Stegagno, M. and De Santis, M. and Muggiasca, M. and Vigan{\'o}, A. and Marchisio, P. and Iasci, A. and Spinillo, A. and Bucceri, A. and Grossi, E. and Rancilio, L. and Della Torre, M. and Parazzini, F. and Dallacasa, P. and Bianchi, U. and Pach{\`i}, A. and Mancuso, S. and Villa, P. and Conti, M. and Principi, N. and Zara, C. and Ravagni, F. and Vignali, M. and Rossi, G. and Selvaggi, L. and Greco, P. and Vimercati, A. and Massi, G. and Innocenti, T. and Fiscella, A. and Martinelli, P. and Sansone, M. and Benedetto, C. and Tibaldi, C. and Ziarati, N. and Tadrist, B. and Thevenieau, D. and Gondry, J. and Paulard, B. and Alisy, C. and Brault, D. and Tordjeman, N. and Mamou, J. and Rozan, M. and Colombani, D. and Pincemaille, O. and Salvetti, A. and Chabanier, C. and Hernandorena, X. and Leroy, J. and Schaal, J. and Balde, P. and Faucher, P. and Lachassinne, E. and Benoit, S. and Douard, D. and Hocke, C. and Barjot, P. and Brouard, J. and Delattre, P. 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and Brunner, C. and Ciraru-Vigneron, N. and Hatem-Gantzer, G. and Fritel, X. and Wallet, A. and Bouille, J. and Milliez, J. and Bensaid Mrejen, D. and Dermer, E. and Noseda, G. and Bardou, D. and Cressaty, J. and Francoual, C. and Carlus Moncomble, C. and Cohen, H. and Blanche, S. and Bastion, H. and Benifla, J. and Benkhatar, F. and Berkane, N. and Herv{\'e}, F. and Ronzier, M. and Ferraris, G. and Tulisso, S. and Scolfaro, C. and Riva, C. and Vierucci, A. and de Luca, M. and Farina, S. and Fundar{\`o}, C. and Genovese, O. and Mereu, G. and Forni, G. and Falconieri, P. and Zuccotti, G. and Riva, E. and Cellini, M. and Baraldi, C. and Consolini, R. and Palla, G. and Ruggeri, M. and Pignata, C. and Guarino, A. and Osimani, P. and Metri, A. and Antonellini, A. and Benaglia, G. and Romano, A. and De Mattia, D. and Caselli, D. and Boni, S. and Dell{'}Erba, G. and Bassanetti, F. and Sticca, M. and Timpano, C. and Magnani, C. and Salvatore, C. and Gambaretto, G. and Lipreri, R. and Tornaghi, 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Hunziker, U. and Kuchler, H. and Gianinazzi, M. and Buhlmann, U. and Biedermann, K. and Lauper, U. and Irion, O. and Brunelli, A. and Spoletini, G. and Schreyer, A. and Hosli, I. and Saurenmann, E. and Drack, G. and Isenschmid, M. and Poorbeik, M. and Schupbach, J. and Perrin, L. and Erb, P. and Joller, H. and Dillon, M. and Boyer, P. and Liao, D. and Keller, M. and Deveikis, A. and Khoury, M. and Diaz, C. and Pacheco-Acosta, E. and Cooper, E. and Mesthene, D. and Pitt, J. and Higgins, A. and Moroso, G. and Rich, K. and Turpin, D. and Cooper, N. and Smeriglio, V. and McKinlay, S. and Ellis, S.
DOI: 10.1056/NEJM199904013401301
1999

Therapeutic and other interventions to reduce the risk of mother-to-child transmission of HIV-1 in Europe
British Journal of Obstetrics and Gynaecology
Thorne, C. and Newell, M.-L. and Bailey, A. and Peckham, C.S. and Giaquinto, C. and Ruga, E. and De Rossi, A. and Truscia, D. and Grosch-Worner, I. and Schafer, A. and Mok, J. and Johnstone, F. and Omenaca, F. and Jiminez, J. and De Alba, C. and Garcia-Rodriguez, M.C. and Bates, I. and De Jose, I. and Hawkins, F. and Martinez Zapico, R. and Asensi-Botet, F. and Otero, M.C. and Perez-Tamarit, D. and Gonzalez Molina, A. and Canosa, H. and Scherpbier, H. and Boer, K. and Bohlin, A.B. and Lindgren, S. and Belfrage, E. and Levy, J. and Alimenti, A. and Barlow, P. and Ferrazin, A. and Dre Maria, A. and Gotta, C. and Maritati, V. and Mur, A. and Rovira, M.T. and Paya, A. and Coll, O. and Fortuny, C. and Boguna, J. and Casellas Caro, M. and Canet, Y. and Pardi, G. and Semprini, A.E. and Ravizza, M. and Castagna, C. and Fiore, S. and Guerra, B. and Bianchi, S. and Bovicelli, L. and Prati, E. and Zanelli, S. and Duse, M. and Soresina, A. and Scaravelli, G. and Stegagno, M. and De Santis, M. and Muggiasca, M.-L. and Marchisio, P. and Iasci, A. and Spinillo, A. and Bucceri, A. and Grossi, E. and Rancilio, L. and Smith, R. and Lewis, A.-M.
1998

Hospitalization of children born to human immunodeficiency virus- infected women in Europe
Pediatric Infectious Disease Journal
Thorne, C. and Newell, M.-L. and Dunn, D. and Peckham, C. and Giaquinto, C. and Ruga, E. and Cozzani, S. and De Rossi, A. and D{'}Elia, R. and Grosch-W{\"o}rner, I. and Mok, J. and Ome{\~n}aca, F. and Garcia-Rodriguez, M.C. and Bates, I. and De Jos{\'e}, I. and Hawkins, F. and Martinez Zapico, R. and Asensi-Botet, F. and Otero, M.C. and P{\'e}rez-Tamarit, D. and Gonzalez Molina, A. and Canosa, C. and Scherpbier, H. and Bohlin, A.B. and Belfrage, E. and Levy, J. and Alimenti, A. and Ferrazin, A. and De Maria, A. and Gotta, C. and Mur, A. and Rovira, M.T. and Paya, A.
DOI: 10.1097/00006454-199712000-00010
1997

Detection of virus in vertically exposed HIV-antibody-negative children
The Lancet
M-L Newell and D Dunn and C Peckham and A De Maria and A Ferrazin and A De Rossi and C Giaquinto and J Levy and A Alimenti and A Ehrnst and A-B Bohlin and R Ljung
DOI: 10.1016/s0140-6736(96)90401-8
01/1996

The HIV-exposed child,L'enfant exposé au virus d'immunodéficience humaine
Archives of Public Health
Levy, J. and Alimenti, A.
1996

Low incidence of congenital toxoplasmosis in children born to women infected with human immunodeficiency virus
European Journal of Obstetrics and Gynecology and Reproductive Biology
Giaquinto, C. and Grosch-W{\"o}rner, I. and Mok, J. and Ome{\~n}aca Teres, F. and Martinez-Zapico, R. and Bates, I. and Hawkins, F. and Canosa, C.A. and Scherpbier, H. and Bohlin, A.B. and Forsgren, M. and Levy, J. and Alimenti, A. and Ferrazin, A. and De Maria, A. and Gotta, C. and M{\^u}r, A. and Dunn, D. and Newell, M.-L. and Gilbert, R. and Petersen, E. and Peckham, C.
DOI: 10.1016/0301-2115(96)02497-9
1996

Vertical transmission of HIV-1: Maternal immune status and obstetric factors
AIDS
Newell, M.-L. and Dunn, D.T. and Peckham, C.S. and Semprini, A.E. and Pardi, G. and Giaquinto, C. and Ruga, E. and De Rossi, A. and Truscia, D. and Grosch-Worner, I. and Schafer, A. and Mok, J. and Johnstone, F. and Omenaca Teres, F. and Jiminez, J. and de Alba, C. and Garcia-Rodriguez, M.C. and Bates, I. and de Jose, I. and Hawkins, F. and Martinez Zapico, R. and Canosa, C.A. and Galbis, G. and Scherpbier, H. and Boer, K. and Bohlin, A.B. and Lindgren, S. and Ehrnst, A. and Anzen, B. and Belfrage, E. and Levy, J. and Alimenti, A. and Barlow, P. and Ferrazin, A. and De Maria, A. and Gotta, C. and Maritati and Mur, A. and Gris, J. and Rovira Puges, M.T. and Coll, O. and Fortuny, C. and Boguna, J. and Casellas Caro, M. and Canet, Y. and Ravizza, M. and Castagna, C. and Fiore, S. and Guerra, B. and Dallacasa, P. and Bianchi, S. and Bovicelli, L. and Prati, E. and Zanelli, S. and Duse, M. and Soresina, A. and Scaravelli, G. and Stegagno, M. and De Santis, M. and Muggiasca, M.L. and Iasci, A. and Spinillo, A. and Bucceri, A. and Grossi, E. and Rancilio, L.
DOI: 10.1007/BF00776044
1996

Detection of virus in vertically exposed HIV-antibody-negative children
Lancet
Newell, M.-L. and Dunn, D. and De Maria, A. and Ferrazin, A. and De Rossi, A. and Giaquinto, C. and Levy, J. and Alimenti, A. and Ehrnst, A. and Bohlin, A.-B. and Ljung, R. and Peckham, C.
DOI: 10.1016/S0140-6736(96)90401-8
1996

Quantitation of HIV-1 in whole blood of infected children
AIDS
Ariane Alimenti and Katherine Luzuriaga and John L. Sullivan and Chantal Van den Borre and Georges Zissis and Jack Levy
DOI: 10.1097/00002030-199407000-00005
07/1994

Endoscopy in HIV infected children,L'endoscopie chez l'enfant infecté par le Virus d'Immunodéficience Humaine
Acta Endoscopica
Souayah, H. and Alimenti, A. and Levy, J.
DOI: 10.1007/BF02968670
1994

Transmission of HIV-1 from one child to another
New England Journal of Medicine
Alimenti, A. and Levy, J. and Fremont-Smith, K. and Dunn, D. and Newell, M.-L. and Friedland, G.H. and Gaur, S. and Frenkel, L.D. and Dubin, D.T. and Laraque, F.
DOI: 10.1056/NEJM199405053301814
1994

Normal Immune Function and Inability to Isolate Virus in Culture in an Individual with Long-Term Human Immunodeficiency Virus Type 1 Infection*
AIDS Research and Human Retroviruses
Greenough, T.C. and Somasundaran, M. and Brettler, D.B. and Hesselton, R.M. and Alimenti, A. and Kirchhoff, F. and Panicali, D. and Sullivan, J.L.
DOI: 10.1089/aid.1994.10.395
1994

Excellent sensitivity and specificity of HIV-1 cultures using whole blood
AIDS
A. Alimenti and J. L. Sullivan and J. Levy and K. Luzuriaga
DOI: 10.1097/00002030-199308000-00017
08/1993

Secondary infection with parvovirus B19 in an HIV-positive patient
AIDS
J. A.G. Bremner and S. Beard and B. J. Cohen and A. Alimenti and J. Levy
DOI: 10.1097/00002030-199308000-00021
08/1993

Early Viremia and Immune Responses in Vertical Human Immunodeficiency Virus Type 1 Infection
Journal of Infectious Diseases
Luzuriaga, K. and McQuilken, P. and Alimenti, A. and Somasundaran, M. and Hesselton, R. and Sullivan, J.L.
DOI: 10.1093/infdis/167.5.1008
1993

Diagnosis of Vertical Human Immunodeficiency Virus Type 1 Infection byWhole Blood Culture
Journal of Infectious Diseases
A. Alimenti and M. O'Neill and J. L. Sullivan and K. Luzuriaga
DOI: 10.1093/infdis/166.5.1146
11/1992

Research

LONG TERM HEALTH OUTCOMES OF HIV UNINFECTED CHILDREN BORN TO HIV INFECTED MOTHERS
This study explores the accessibility of the BC cohort and examines the longer term health outcomes of HIV negative children exposed to antiretroviral therapy perinatally using a health questionnaire and by contact with their past or current health care professionals.
At the end of this pilot project, based on study outcomes, we will develop and implement a comprehensive and outcome oriented study exploring:
• the incidence of poor health outcomes such as growth abnormalities, susceptibility to infection, admissions to hospital, significant developmental disorders, poor scholastic performance, interaction with law enforcement, etc. in ARV exposed children compared to a age, sex and socio-economic status (parental education, household income and first 3 digits of postal code) matched control population;
• the association between length and type of ARV exposure and specific poor health outcomes;
• a comparison with the health outcomes of uninfected ARV exposed children from BC and three other pediatric HIV referral centres in Canada.

We hypothesize that, compared to all British Columbian children, HIV-uninfected, ARV exposed children will have a higher frequency of poor health outcomes such as described above. Enrolment is 95% complete. This pilot of British Columbia HIV/ARV exposed children is largely hypothesis generating and will guide the development of a larger multi-centred project.

CANADIAN PERINATAL HIV SURVEILLANCE PROGRAM (CPHSP)
in collaboration with the Canadian HIV Trials Network (CTN) and Public Health Agency of Canada (PHAC).

This web-based database collects data from 21 pediatric sites covering all Canadian provinces and territories. The program generates descriptive data annually on:
A. HIV exposed children:
• the number of infants born to HIV positive women in Canada
• demographic, geographic and risk factor parameters of mother-infant pairs
• the use of antiretroviral therapy (ART) in pregnancy (proportion of HIV+ pregnant women receiving ART, type and duration of ART in mother and infant)
• the rate of mother-to-child HIV transmission
• infant outcomes (mortality)
B. HIV infected children:
•the number of known perinatally infected infants and children followed at the centres
•annual update on their clinical status, immune status and mortality

IS THE BONE HEALTH OF HIV INFECTED CHILDREN AND ADOLESCENTS COMPROMISED?
A substudy of CARMA, the CIHR emerging team grant "Mechanism of aging following exposure to HIV antiretroviral drugs."

Both HIV and the antiretrovirals are suspected to affect the acquisition of bone mass, raising concerns about bone strength and fracture risk.
We have completed year 1 of this 3-year longitudinal study involving HIV infected children in BC (approximately 30). The objectives are to:
a. Determine whether HIV infected children have low bone mass compared to a healthy local population, using DXA (Dual-Energy X-ray Absorptiometry)
b. Assess bone strength using pQCT (peripheral quantitative computed tomography, a novel scanning technology
c. Determine the role of calcium and vitamin D intake, physical activity, muscle power, severity of disease and HIV medications on bone mass and bone strength.
Results are compared to an existing group of healthy BC children.
This study will set the basis for a multicentre study and for clinical guidelines for assessment and intervention.