Overview

Research focuses primarily on Epilepsy in the pediatric population, as well as epilepsy genetics.

Publications

Genomic Context Analysis of de Novo STXBP1 Mutations Identifies Evidence of Splice Site DNA-Motif Associated Hotspots
G3: Genes|Genomes|Genetics
Mohammed Uddin, Marc Woodbury-Smith, Ada J. S. Chan, Ammar Albanna, Berge Minassian, Cyrus Boelman, Stephen W. Scherer
DOI: 10.1534/g3.118.200080
02/2018

Global characterization of copy number variants in epilepsy patients from whole genome sequencing
Jean Monlong, Simon L. Girard, Caroline Meloche, Maxime Cadieux-Dion, Danielle M. Andrade, Ron G. Lafreniere, Micheline Gravel, Dan Spiegelman, Alexandre Dionne-Laporte, Cyrus Boelman, Fadi Hamdan, Jacques L. Michaud, Guy Rouleau, Berge A. Minassian, Guillaume Bourque, Patrick Cossette
DOI: 10.1101/199224
10/2017

Clinical Experience With Perampanel for Refractory Pediatric Epilepsy in One Canadian Center
Journal of Child Neurology
Anita N. Datta, Qi Xu, Shafina Sachedina, Cyrus Boelman, Linda Huh, Mary B. Connolly
DOI: 10.1177/0883073817709195
05/2017

Increased subcortical oligodendroglia-like cells in pharmacoresistant focal epilepsy in children correlate with extensive epileptogenic zones
Epilepsia
Satoru Sakuma, William C. Halliday, Ruka Nomura, Shiro Baba, Yosuke Sato, Kazuo Okanari, Midori Nakajima, Elysa Widjaja, Cyrus Boelman, Ayako Ochi, O. Carter Snead, James T. Rutka, James Drake, Steven Miller, Hiroshi Otsubo
DOI: 10.1111/epi.13590
11/2016

A.01 Targeted analysis of whole exome sequencing and genotype-phenotype correlation in epileptic encephalopathies
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
SE Buerki, EB Toyota, I Guella, M McKenzie, D Evans, S Adam, MI van Allen, C Boelman, G Horvath, CD Van Karnebeek, P Eydoux, L Huh, A Datta, KA Selby, A Michoulas, TN Nelson, MJ Farrer, MB Demos, MB Connolly
DOI: 10.1017/cjn.2016.53
06/2016

KCNQ2 mutations: genotype-phenotype association beyond epilepsy
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
SE Buerki, GA Horwath, MI Van Allen, A Datta, C Boelman, Z Abu Sharar, B Sayson, MB Connolly, CD van Karnebeek, MK Demos
DOI: 10.1017/cjn.2015.66
05/2015

EEG in asymptomatic relatives of idiopathic epilepsy; a prospective study
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
BM Duaa, C Boelman, L Brunga, BA Minassian, D Andrade
DOI: 10.1017/cjn.2015.128
05/2015

Faulty cardiac repolarization reserve in alternating hemiplegia of childhood broadens the phenotype
Brain
Jaffer, F. and Avbersek, A. and Vavassori, R. and Fons, C. and Campistol, J. and Stagnaro, M. and De Grandis, E. and Veneselli, E. and Rosewich, H. and Gianotta, M. and Zucca, C. and Ragona, F. and Granata, T. and Nardocci, N. and Mikati, M. and Helseth, A.R. and Boelman, C. and Minassian, B.A. and Johns, S. and Garry, S.I. and Scheffer, I.E. and Gourfinkel-An, I. and Carrilho, I. and Aylett, S.E. and Parton, M. and Hanna, M.G. and Houlden, H. and Neville, B. and Kurian, M.A. and Novy, J. and Sander, J.W. and Lambiase, P.D. and Behr, E.R. and Schyns, T. and Arzimanoglou, A. and Cross, J.H. and Kaski, J.P. and Sisodiya, S.M.
DOI: 10.1093/brain/awv243
2015

Spatial relationship between fast and slow components of ictal activities and interictal epileptiform discharges in epileptic spasms
Clinical Neurophysiology
Akiyama, T. and Akiyama, M. and Kobayashi, K. and Okanishi, T. and Boelman, C.G. and Nita, D.A. and Ochi, A. and Go, C.Y. and Snead, O.C. and Rutka, J.T. and Drake, J.M. and Chuang, S. and Otsubo, H.
DOI: 10.1016/j.clinph.2014.12.005
2015

Preictal surrender of post-spike slow waves to spike-related high-frequency oscillations (80-200 Hz) is associated with seizure initiation
Epilepsia
Sato, Y. and Doesburg, S.M. and Wong, S.M. and Boelman, C. and Ochi, A. and Otsubo, H.
DOI: 10.1111/epi.12728
2014

Antithrombotic therapy for secondary stroke prevention in bacterial meningitis in children
Journal of Pediatrics
Boelman, C. and Shroff, M. and Yau, I. and Bjornson, B. and Richrdson, S. and Deveber, G. and Macgregor, D. and Moharir, M. and Askalan, R.
DOI: 10.1016/j.jpeds.2014.06.013
2014

Identical ATP1A3 mutation causes alternating hemiplegia of childhood and rapid-onset dystonia parkinsonism phenotypes
Pediatric Neurology
Boelman, C. and Lagman-Bartolome, A.M. and MacGregor, D.L. and McCabe, J. and Logan, W.J. and Minassian, B.A.
DOI: 10.1016/j.pediatrneurol.2014.08.015
2014

Interictal high frequency oscillations correlating with seizure outcome in patients with widespread epileptic networks in tuberous sclerosis complex
Epilepsia
Okanishi, T. and Akiyama, T. and Tanaka, S.-I. and Mayo, E. and Mitsutake, A. and Boelman, C. and Go, C. and Snead, O.C. and Drake, J. and Rutka, J. and Ochi, A. and Otsubo, H.
DOI: 10.1111/epi.12761
2014

Adjunctive dexamethasone in adults with meningococcal meningitis
Neurology
Boelman, C.G.
DOI: 10.1212/01.wnl.0000430451.92743.a5
2013

Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: application to 452 patient data sets
NeuroImage
Arnaud Charil, Alex P Zijdenbos, Jonathan Taylor, Cyrus Boelman, Keith J Worsley, Alan C Evans, Alain Dagher
DOI: 10.1016/s1053-8119(03)00117-4
07/2003

Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: Application to 452 patient data sets
NeuroImage
Charil, A. and Zijdenbos, A.P. and Taylor, J. and Boelman, C. and Worsley, K.J. and Evans, A.C. and Dagher, A.
DOI: 10.1016/S1053-8119(03)00117-4
2003

Correlation between MS lesions and disability using 3D voxel-based statistical analysis
NeuroImage
Arnaud Charil, Alex Zijdenbos, Cyrus Boelman, Jonathan Taylor, Keith J. Worsley, Alan C. Evans, Alain Dagher
DOI: 10.1016/s1053-8119(00)91601-x
05/2000

Correlation between MS lesions and disability using 3D voxel-based statistical analysis
NeuroImage
Charil, A. and Zijdenbos, A. and Boelman, C. and Taylor, J. and Worsley, K.J. and Evans, A.C. and Dagher, A.
2000

Research

The Personalized Medicine in the Treatment of Epilepsy
Identification of Genes Predisposing to the disease and to resistance to anti-epileptic treatments study is looking to identify genetic mutations responsible for various forms of epilepsy, as well as to understand the impact of genetic analysis and whole genome sequencing which will be used to study the participant's genes or their genome. This can lead to a better understanding of the disease and enable earlier diagnosis, as well as develop understanding of the genetic factors involved in anti-epileptic medication response at a personalized level.