The following research projects led by BC Children's Hospital and BC Women's Hospital researchers are focused on how the coronavirus spreads and the impact the virus has on certain groups.
Click on the study titles below for more information.
- Rapid Research in the Child Cohort to Inform Canada's Response to the COVID-19 Pandemic: Investigation
Stuart Turvey, Principal Investigator
We will study the direct effects of coronavirus infection and the indirect effects of the COVID-19 pandemic in the existing CHILD Cohort Study. CHILD involves 3500 families in BC, Alberta, Manitoba and Ontario who have been followed since before their children were born in 2008-2010. Most recently, children provided detailed health data and blood samples in 2018-2020 (just before the pandemic), providing a unique opportunity to study how children's pre-pandemic health and immune status influences the risk and outcome of coronavirus infection. We will now ask all CHILD family members to report COVID-19 symptoms using a text messaging system, and provide a few drops of blood for COVID-19 antibody testing using a simple at-home collection kit. Families will also complete surveys about their physical and mental health, behaviours and emotions during the pandemic.
This study will help us understand how Canadian families are being affected - both directly through infection and indirectly through pandemic management policies. Our research will provide important real-time data to Public Health authorities about coronavirus infection, symptoms, transmission and immunity in 12,000 Canadians in 4 provinces (CHILD children, siblings, parents) to inform Canada's COVID-19 response.
- COVID-19 Immunological Investigation: Quality, quantity and kinetics of antibody and cell-mediated responses
Danuta Skowronski, Principal Investigator
To validate SARS-CoV-2 antibody assays in development and to evaluate the type, quantity, quality and kinetics of the immune response. To collect blood from confirmed COVID-19 cases to enable validation of antibody assays, guide timing of specimen collection for serological diagnosis and to support future investigation and fuller understanding of the immune response more generally to COVID-19, other coronaviruses and emerging or re-emerging respiratory pathogens.
- Covid-19 Infections In Transplant Recipients: A Multicenter Registry
Hana Mitchell, Principal Investigator
The purpose of this multicenter study is to prospectively characterize COVID-19 infections over a 1- year period in Canadian adult and paediatric SOT recipients using a centralized registry system through the University Hospital Network, Toronto, Ontario. HYPOTHESIS: COVID-19 infection may have unique clinical presentation and long-term sequelae in solid organ transplant recipients JUSTIFICATION: To date there are only scant reports of COVID-19 impacting solid-organ transplant (SOT) recipients. Asa result of immunosuppression, an atypical clinical presentation is expected and has been described. Further data is needed to better define the impact of COVID-19 in immunosuppressed transplant recipients in order to guide prevention, screening, and management.
- Canadian COVID-19 in Pregnancy Surveillance: Epidemiology, Maternal and Infant Outcomes
Deborah Money, Principal Investigator
Globally, there are significantly limited data on SARS-CoV-2 to inform recommendations for pregnant women and their care providers. This multi-provincial observational project serves to better understanding of COVID-19 in pregnancy, to increase understanding of the epidemiology of COVID-19 in pregnancy, and to provide critical data to inform recommendations for pregnant women and their infants. A pan-provincial approach is in progress with provincial data collection to be combined for a national dataset of cases of COVID-19 in pregnancy.
- All-cause and cause-specific mortality and acute morbidity attributable to Covid-19 and medical history associated with severe Covid-19 infection in BC
Sarka Lisonkova, Principal Investigator
Prediction models about the future course of the epidemic rely mainly on the trends in numbers of Covid-19 positive individuals, hospitalizations, and deaths. These estimates may not be accurate, however, due to a limited availability of the Covid-19 testing and its potential inaccuracies. There is an urgent need to evaluate the overall impact of the pandemic regardless of the accuracy of available data. Our research will provide an insight into who is most impacted by the pandemic in BC, including the primary effects and the secondary effects not directly caused by the virus. In addition, we will investigate the association between past medical history and the severity of symptoms among Covid-19 positive individuals. Our results will help to plan the next steps in the preventive efforts.