Overview

My work utilizes multimodal brain imaging along with cutting edge analytical techniques to quantify complex brain network organization and dynamics.

 

My primary goal is to map complex clinical phenotypes to complex anatomical, functional, and biochemical organization in brain systems that support attention and social awareness. I am building research partnerships with clinicians to better understand developmental, neuropsychiatric, and neurological disorders such as autism, attention deficit/hyperactivity disorder, anxiety, chronic pain, and traumatic brain injury. A key emphasis is to pursue avenues holding promise for the development of non-pharmacological interventions that can improve quality of life for children and families affected by these conditions.

Publications

Emerging neuroimaging technologies: Toward future personalized diagnostics, prognosis, targeted intervention, and ethical challenges
Oxford Scholarship Online
Urs Ribary, Alex L. MacKay, Alexander Rauscher, Christine M. Tipper, Deborah E. Giaschi, Todd S. Woodward, Vesna Sossi, Sam M. Doesburg, Lawrence M. Ward, Anthony Herdman, Ghassan Hamarneh, Brian G. Booth, Alexander Moiseev
DOI: 10.1093/oso/9780198786832.003.0002
09/2017

Altered balance of functional brain networks in Schizophrenia
Psychiatry Research: Neuroimaging
Todd S. Woodward, KaWai Leong, Nicole Sanford, Christine M. Tipper, Katie M. Lavigne
DOI: 10.1016/j.pscychresns.2016.01.003
02/2016

Processing Narratives Concerning Protected Values: A Cross-Cultural Investigation of Neural Correlates
Cerebral Cortex
Jonas T. Kaplan, Sarah I. Gimbel, Morteza Dehghani, Mary Helen Immordino-Yang, Kenji Sagae, Jennifer D. Wong, Christine M. Tipper, Hanna Damasio, Andrew S. Gordon, Antonio Damasio
DOI: 10.1093/cercor/bhv325
01/2016

Body language in the brain: constructing meaning from expressive movement
Front. Hum. Neurosci.
Christine M. Tipper, Giulia Signorini, Scott T. Grafton
DOI: 10.3389/fnhum.2015.00450
08/2015

Reduced functional connectivity during controlled semantic integration in schizophrenia: A multivariate approachReduced Functional Connectivity
Hum. Brain Mapp.
Todd S. Woodward, Christine M. Tipper, Alexander L. Leung, Katie M. Lavigne, Nicole Sanford, Paul D. Metzak
DOI: 10.1002/hbm.22820
05/2015

Maintaining a cautious state of mind during a recognition test: A large-scale fMRI study
Neuropsychologia
Aminoff, E.M. and Freeman, S. and Clewett, D. and Tipper, C. and Frithsen, A. and Johnson, A. and Grafton, S.T. and Miller, M.B.
DOI: 10.1016/j.neuropsychologia.2014.12.011
2015

Structurally-Constrained Relationships between Cognitive States in the Human Brain
PLoS Comput Biol
Ann M. Hermundstad, Kevin S. Brown, Danielle S. Bassett, Elissa M. Aminoff, Amy Frithsen, Arianne Johnson, Christine M. Tipper, Michael B. Miller, Scott T. Grafton, Jean M. Carlson
DOI: 10.1371/journal.pcbi.1003591
05/2014

Escaping the here and now: Evidence for a role of the default mode network in perceptually decoupled thought
NeuroImage
Jonathan Smallwood, Christine Tipper, Kevin Brown, Benjamin Baird, Haakon Engen, Joseph R. Michaels, Scott Grafton, Jonathan W. Schooler
DOI: 10.1016/j.neuroimage.2012.12.012
04/2013

Structural foundations of resting-state and task-based functional connectivity in the human brain
Proceedings of the National Academy of Sciences of the United States of America
Hermundstad, A.M. and Bassett, D.S. and Brown, K.S. and Aminoff, E.M. and Clewett, D. and Freeman, S. and Frithsen, A. and Johnson, A. and Tipper, C.M. and Miller, M.B. and Grafton, S.T. and Carlson, J.M.
DOI: 10.1073/pnas.1219562110
2013

Individual differences in shifting decision criterion: A recognition memory study
Mem Cogn
Elissa M. Aminoff, David Clewett, Scott Freeman, Amy Frithsen, Christine Tipper, Arianne Johnson, Scott T. Grafton, Michael B. Miller
DOI: 10.3758/s13421-012-0204-6
05/2012

Decoding intention: A neuroergonomic perspective
NeuroImage
Scott T. Grafton, Christine M. Tipper
DOI: 10.1016/j.neuroimage.2011.05.064
01/2012

Attitudes trigger motor behavior through conditioned associations: Neural and behavioral evidence
Social Cognitive and Affective Neuroscience
McCall, C. and Tipper, C.M. and Blascovich, J. and Grafton, S.T.
DOI: 10.1093/scan/nsr057
2012

Pupillometric Evidence for the Decoupling of Attention from Perceptual Input during Offline Thought
PLoS ONE
Jonathan Smallwood, Kevin S. Brown, Christine Tipper, Barry Giesbrecht, Michael S. Franklin, Michael D. Mrazek, Jean M. Carlson, Jonathan W. Schooler
DOI: 10.1371/journal.pone.0018298
03/2011

Brain Responses to Biological Relevance
Journal of Cognitive Neuroscience
Christine M. Tipper, Todd C. Handy, Barry Giesbrecht, Alan Kingstone
DOI: 10.1162/jocn.2008.20510
05/2008

Attentional orienting to graspable objects: what triggers the response?
NeuroReport
Todd C. Handy, Christine M. Tipper
DOI: 10.1097/wnr.0b013e3281332674
06/2007

Attentional orienting to graspable objects: what triggers the response?
Neuroreport
Handy, Todd C. and Tipper, Christine M.
DOI: 10.1097/WNR.0b013e3281332674
2007

Motor experience with graspable objects reduces their implicit analysis in visual- and motor-related cortex
Brain Research
Todd C. Handy, Christine M. Tipper, Jana Schaich Borg, Scott T. Grafton, Michael S. Gazzaniga
DOI: 10.1016/j.brainres.2006.04.059
06/2006

Is inhibition of return a reflexive effect?
Cognition
Christine Tipper, Alan Kingstone
DOI: 10.1016/j.cognition.2005.02.003
10/2005

Processing efficiency of a verbal working memory system is modulated by amphetamine: an fMRI investigation
Psychopharmacology
Christine M. Tipper, Tara A. Cairo, Todd S. Woodward, Anthony G. Phillips, Peter F. Liddle, Elton T. C. Ngan
DOI: 10.1007/s00213-005-0025-4
06/2005

Placing a tool in the spotlight: spatial attention modulates visuomotor responses in cortex
NeuroImage
Todd C. Handy, Jana Schaich Borg, David J. Turk, Christine M. Tipper, Scott T. Grafton, Michael S. Gazzaniga
DOI: 10.1016/j.neuroimage.2005.01.029
05/2005

Attending to a dynamic world: Influences of the optic flow field on visuospatial attention and the P1 ERP component.
Journal of Cognitive Neuroscience
Tipper, C and Bischof, W and Handy, T
2005

The eyes have it!: An fMRI investigation
Brain and Cognition
Alan Kingstone, Christine Tipper, Jelena Ristic, Elton Ngan
DOI: 10.1016/j.bandc.2004.02.037
07/2004

Bivalency is Costly: Bivalent Stimuli Elicit Cautious Responding
Experimental Psychology
Todd S. Woodward, Beat Meier, Christine Tipper, Peter Graf
DOI: 10.1026//1618-3169.50.4.233
10/2003

Temporal lobe dysfunction in patients with schizophrenia during performance of a speech and non-speech analogue detection task: An event-related fMRI study
Schizophrenia Research
Cairo, TA and Liddle, PF and Vouloumanos, A and Tipper, CM and Anderson, CM and Werker, JF and Laurens, KR and Bates, AT and Ngan, ETC
2002

A role for the anterior cingulate cortex in resolution of prior inhibition
Journal of Cognitive Neuroscience
Woodward, T and Laurens, K and Ruff, C and Steffen, M and Tipper, C and Ngan, E and Liddle, P
2002

Attitudes trigger motor behavior through arbitrarily conditioned associations: Neural and behavioral evidence(528002014-075)
PsycEXTRA Dataset
Cade McCall, Christine Tipper, Jim Blascovich, Scott Grafton
DOI: 10.1037/e528002014-075

Research

The role of neural simulation in action understanding: A simultaneous fMRI-EEG study
This study investigates the role of agent-independent brain substrates in coding various properties of action. Previous research has revealed a functionally stratefied, hierarchiacally organized action observation brain network (AON). This network is involved in representing both executed and observed actions. There has been much debate over whether this functional overlap reflects a human "mirror neuron system". This study utilized a novel virtual reality task and an fMRI design known as repetition suppression (RS) to directly test for brain substrates that responded identically regardless of whether an action was seen or performed. EEG data collected simultaneously also enables us to chart the functional dynamics linked to the integration of distinct brain processes underlying action representation.
 

Dynamic brain networks for the integration of attention functions: A combined fMRI-EEG study
This study collected fMRI and dense-array EEG data on the same participants while they perfromed a challenging, attention-demaning task. Using a variance-based brain imaging analysis technique known as constrained principal component analysis (CPCA), we aim to identify distinct brain networks that mediate the various component processes of attention, and quantify the functional dynamics underlying their inegration. A key component of this study is the development of analytical techniques to combine the precise spatial information provided by fMRI with the precise temporal information provided by EEG.
 

Functional brain networks of the frontoparietal attention system
Paradoxically, despite being one of the most intensively studied topics in cognitive neuroscience, “attention” remains a nebulous concept. This is because attention is not a unitary phenomenon with a single underlying brain mechanism, but rather is comprised of multiple component processes mediated cortically by a distributed network of frontal and parietal brain regions. The goal of this project is to distinguish component processes of attention and determine their neural substrates. This study utilizes fMRI and a novel application of a variance-based brain analytical technique known as constrained principal component analysis (CPCA) to identify functional brain networks that mediate the various component process of attention.
 

Research Group Members

Ella Weik
Raysa Santos, Undergraduate Student
Harveen Hayer, Medical Student
Braden Hale, Work Learn Student
Elena Klimova