Overview

My research interests are in three principle areas:

Use of central nervous system imaging technologies to define physiological parameters or relevance to the treatment of children with hydrocephalus

Health care systems development and change, focusing on the development of skills in providers through the analysis of risk and safety during surgical care.

Spinal cord disorders affecting children including spina bifida and occipital-cervical cord compression.

Publications

Choosing Wisely Canada: Pediatric Neurosurgery Recommendations
Paediatrics & Child Health
Julia A E Radic, D Douglas Cochrane
DOI: 10.1093/pch/pxy012
03/2018

Reinfection after treatment of first cerebrospinal fluid shunt infection: a prospective observational cohort study
Journal of Neurosurgery: Pediatrics
Tamara D. Simon, Matthew P. Kronman, Kathryn B. Whitlock, Nancy E. Gove, Nicole Mayer-Hamblett, Samuel R. Browd, D. Douglas Cochrane, Richard Holubkov, Abhaya V. Kulkarni, Marcie Langley, David D. Limbrick, Thomas G. Luerssen, W. Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Chevis Shannon, Mandeep Tamber, John C. Wellons, William E. Whitehead, John R. W. Kestle
DOI: 10.3171/2017.9.peds17112
02/2018

Teams, Competence, and Safety in Surgery
Quality and Safety in Neurosurgery
David D. Cochrane and Alison Muniak and Colleen Kennedy
DOI: 10.1016/b978-0-12-812898-5.00007-2
2018

Central adrenal insufficiency following traumatic brain injury: a missed diagnosis in the critically injured
Child's Nervous System
Eileen Fan, Peter W. Skippen, Michael A. Sargent, David D. Cochrane, Jean-Pierre Chanoine
DOI: 10.1007/s00381-017-3536-5
07/2017

Factors contributing to spinal cord infarction occurring in surgery performed in the prone position
Child's Nervous System
D D Cochrane
DOI: 10.1007/s00381-017-3402-5
03/2017

Ventricular catheter entry site and not catheter tip location predicts shunt survival: a secondary analysis of 3 large pediatric hydrocephalus studies
Journal of Neurosurgery: Pediatrics
William E. Whitehead, Jay Riva-Cambrin, Abhaya V. Kulkarni, John C. Wellons, Curtis J. Rozzelle, Mandeep S. Tamber, David D. Limbrick, Samuel R. Browd, Robert P. Naftel, Chevis N. Shannon, Tamara D. Simon, Richard Holubkov, Anna Illner, D. Douglas Cochrane, James M. Drake, Thomas G. Luerssen, W. Jerry Oakes, John R. W. Kestle
DOI: 10.3171/2016.8.peds16229
02/2017

Improving diagnosis of pediatric central nervous system tumours: aiming for early detection
Canadian Medical Association Journal
Ran D. Goldman, Sylvia Cheng, D. Douglas Cochrane
DOI: 10.1503/cmaj.160074
11/2016

Letter to the Editor: Thirty-day outcomes of cerebrospinal fluid shunt surgery: modeling using data from the National Surgical Quality Improvement Program–Pediatrics
Journal of Neurosurgery: Pediatrics
Monique Marguerie, D. Douglas Cochrane
DOI: 10.3171/2016.4.peds16222
10/2016

Endoscopic third ventriculostomy in children: prospective, multicenter results from the Hydrocephalus Clinical Research Network
Journal of Neurosurgery: Pediatrics
Abhaya V. Kulkarni, Jay Riva-Cambrin, Richard Holubkov, Samuel R. Browd, D. Douglas Cochrane, James M. Drake, David D. Limbrick, Curtis J. Rozzelle, Tamara D. Simon, Mandeep S. Tamber, John C. Wellons, William E. Whitehead, John R. W. Kestle, for the Hydrocephalus Clinical Research Network
DOI: 10.3171/2016.4.peds163
10/2016

Radiographic predictors of deterioration in patients with lumbosacral lipomas
Journal of Neurosurgery: Pediatrics
Albert Tu, Alexander R. Hengel, D. Douglas Cochrane
DOI: 10.3171/2016.1.peds15614
08/2016

Using systems thinking to support clinical system transformation
Journal of Health Organization and Management
Allan Best, Alex Berland, Carol Herbert, Jennifer Bitz, Marlies W van Dijk, Christina Krause, Douglas Cochrane, Kevin Noel, Julian Marsden, Shari McKeown, John Millar
DOI: 10.1108/jhom-12-2014-0206
05/2016

Ophthalmological outcomes of patients treated for pineal region tumors
Journal of Neurosurgery: Pediatrics
Elizabeth V. Hankinson, Christopher J. Lyons, Juliette Hukin, David D. Cochrane
DOI: 10.3171/2015.10.peds15415
05/2016

A new Hydrocephalus Clinical Research Network protocol to reduce cerebrospinal fluid shunt infection
Journal of Neurosurgery: Pediatrics
John R. W. Kestle, Richard Holubkov, D. Douglas Cochrane, Abhaya V. Kulkarni, David D. Limbrick, Thomas G. Luerssen, W. Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Tamara D. Simon, Marion L. Walker, John C. Wellons, Samuel R. Browd, James M. Drake, Chevis N. Shannon, Mandeep S. Tamber, William E. Whitehead, The Hydrocephalus Clinical Research Network
DOI: 10.3171/2015.8.peds15253
04/2016

The natural history and management of patients with congenital deficits associated with lumbosacral lipomas
Child's Nervous System
Albert Tu, Ross Hengel, D. Douglas Cochrane
DOI: 10.1007/s00381-015-3008-8
01/2016

Sagittal Synostosis Repair Surgery
Pediatric Neurosurgery: Tricks of the Trade
DOI: 10.1055/b-0035-125898
2016

Preoperative ultrasound localization of the lambda in patients with scaphocephaly: a technical note for minimally invasive craniectomy
Journal of Neurosurgery: Pediatrics
Christopher M. Bonfield, D. Douglas Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.3171/2015.5.peds15157
11/2015

Cerebellar cavernous malformation in pediatric patients: defining clinical, neuroimaging, and therapeutic characteristics
Journal of Neurosurgery: Pediatrics
Friederike Knerlich-Lukoschus, Paul Steinbok, Christopher Dunham, David Douglas Cochrane
DOI: 10.3171/2015.1.peds14366
09/2015

Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience
Child's Nervous System
Christopher M. Bonfield, Julia Sharma, D. Douglas Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.1007/s00381-015-2900-6
09/2015

Intraoperative ultrasound in pediatric brain tumors: does the surgeon get it right?
Child's Nervous System
Ash Singhal, A. Ross Hengel, Paul Steinbok, D. Doug Cochrane
DOI: 10.1007/s00381-015-2805-4
08/2015

Radiographic Detectability of Retained Neuropatties in a Cadaver Model
World Neurosurgery
Wangjian Thomas Luo, Robert Almack, John B. Mawson, David Douglas Cochrane
DOI: 10.1016/j.wneu.2015.03.032
08/2015

Pediatric neurosurgery at British Columbia’s Children’s Hospital
Child's Nervous System
Paul Steinbok, Felix Durity, John Kestle, D. Douglas Cochrane
DOI: 10.1007/s00381-015-2733-3
05/2015

25. Occult Spinal Dysraphism
Principle and Practice of Pediatric Neurosurgery
DOI: 10.1055/b-0034-98065
2015

What would I want for my surgery?
Canadian Journal of Surgery
Marlies van Dijk
DOI: 10.1503/cjs.006414
08/2014

Identification of anMLL4-GPS2fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a childNovel t(17;19) in Undifferentiated Spindle Cell Sarcoma
Genes, Chromosomes and Cancer
Elaine O'Meara, Deirdre Stack, Susan Phelan, Naomi McDonagh, Lorna Kelly, Raf Sciot, Maria Debiec-Rychter, Thomas Morris, Doug Cochrane, Poul Sorensen, Maureen J. O'Sullivan
DOI: 10.1002/gcc.22208
08/2014

Pleomorphic xanthoastrocytoma of the spinal cord: case report and literature review
Clinical Neuropathology
Sumit Das, Stephen Yip, Juliette Hukin, Douglas Cochrane, Christopher Dunham
DOI: 10.5414/np300689
05/2014

Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngiomaCase report
Journal of Neurosurgery: Pediatrics
Erick M. Carreras, Christopher J. Lyons, David Doug Cochrane
DOI: 10.3171/2014.2.peds13530
05/2014

Disruption of silicone valve housing in a Codman Hakim Precision valve with integrated SiphonguardReport of 2 cases
Journal of Neurosurgery: Pediatrics
Peter A. Woerdeman, David D. Cochrane
DOI: 10.3171/2014.2.peds13436
05/2014

What Would I Want For My Surgery?
Healthcare Quarterly
Allison Muniak, D. Cochrane, Marlies van Dijk, Andy Hamilton, Stephan Schwarz, J. O’Connor, Ramesh Sahjpaul
DOI: 10.12927/hcq.2015.24124
2014

Growing teratoma syndrome in intracranial non-germinomatous germ cell tumors (iNGGCTs): a risk for secondary malignant transformation—a report of two cases
Child's Nervous System
Torin Glass, D. Douglas Cochrane, Shahrad Rod Rassekh, Karen Goddard, Juliette Hukin
DOI: 10.1007/s00381-013-2295-1
10/2013

CSF complications following intradural spinal surgeries in children
Child's Nervous System
Victor Liu, Christopher Gillis, Doug Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.1007/s00381-013-2276-4
09/2013

Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas
Child's Nervous System
Paul Steinbok, Jaspreet Singh Mangat, John M. Kerr, Michael Sargent, Wihasto Suryaningtyas, Ashutosh Singhal, Doug Cochrane
DOI: 10.1007/s00381-013-2171-z
05/2013

Imaging the course of a hypoplastic cerebellum in a spina bifida newborn
Child's Nervous System
Annick Kronenburg, Kuo Sen Han, Rob Gooskens, Giuseppe Esposito, Douglas Cochrane, Peter Woerdeman
DOI: 10.1007/s00381-013-2156-y
05/2013

Bilateral lambdoid and posterior sagittal craniosynostosis—management, evolution, and outcome
Child's Nervous System
Shibu Pillai, D. Cochrane, A. Singhal, Paul Steinbok
DOI: 10.1007/s00381-013-2155-z
05/2013

Letter to the Editor: Cerebrospinal fluid drainage
Journal of Neurosurgery: Pediatrics
D. Douglas Cochrane
DOI: 10.3171/2012.2.peds1217
04/2013

Ring Apophysis Fracture in Pediatric Lumbar Disc Herniation: A Common Entity
Pediatric Neurosurgery
Ash Singhal, Anish Mitra, Doug Cochrane, Paul Steinbok
DOI: 10.1159/000355127
2013

Does optic nerve sheath diameter on MRI decrease with clinically improved pediatric hydrocephalus?
Child's Nervous System
Ash Singhal, Michael M. H. Yang, Michael A. Sargent, D. Douglas Cochrane
DOI: 10.1007/s00381-012-1937-z
10/2012

Consensus definitions of complications for accurate recording and comparisons of surgical outcomes in pediatric neurosurgeryClinical article
Journal of Neurosurgery: Pediatrics
James M. Drake, Ash Singhal, Abhaya V. Kulkarni, Gabrielle DeVeber, D. Douglas Cochrane, The Canadian Pediatric Neurosurgery Study Group
DOI: 10.3171/2012.3.peds11233
08/2012

Adverse events among children in Canadian hospitals: the Canadian Paediatric Adverse Events Study
Canadian Medical Association Journal
A. G. Matlow, G. R. Baker, V. Flintoft, D. Cochrane, M. Coffey, E. Cohen, C. M. G. Cronin, R. Damignani, R. Dube, R. Galbraith, D. Hartfield, L. A. Newhook, C. Nijssen-Jordan
DOI: 10.1503/cmaj.112153
07/2012

Spinal cord infarction remote from maximal compression in a patient with Morquio syndromeCase report
Journal of Neurosurgery: Pediatrics
Calvin K. W. Tong, James C. H. Chen, D. Douglas Cochrane
DOI: 10.3171/2012.2.peds11522
06/2012

Letter to the Editor: Dilution versus pollution
Journal of Neurosurgery: Pediatrics
D. Douglas Cochrane, David S. Anderson
DOI: 10.3171/2010.11.peds10429
04/2012

Endoscopic fenestration of cavum velum interpositum cysts: a case study of two symptomatic patients
Child's Nervous System
Calvin K. W. Tong, Ashutosh Singhal, D. Douglas Cochrane
DOI: 10.1007/s00381-012-1770-4
04/2012

Introduction for presidential address by Dr Paul Steinbok, President of the ISPN, 2011, Goa India, October 2011
Child's Nervous System
D. Douglas Cochrane
DOI: 10.1007/s00381-012-1695-y
01/2012

BC Patient Safety & Quality Council: Using Network and Social Movement Theory to Improve Healthcare
Healthcare Management Forum
Christina Krause, Doug Cochrane
DOI: 10.1016/j.hcmf.2012.09.002
2012

Improving Care for British Columbians: The Critical Role of Physician Engagement
Healthcare Quarterly
Julian Marsden, Marlies Dijk, Peter Doris, Christina Krause, Doug Cochrane
DOI: 10.12927/hcq.2012.23163
2012

Identification by families of pediatric adverse events and near misses overlooked by health care providers
Canadian Medical Association Journal
J. P. Daniels, K. Hunc, D. D. Cochrane, R. Carr, N. T. Shaw, A. Taylor, S. Heathcote, R. Brant, J. Lim, J. M. Ansermino
DOI: 10.1503/cmaj.110393
11/2011

Stridor at birth predicts poor outcome in neonates with myelomeningocele
Child's Nervous System
Eylem Ocal, Beverly Irwin, Douglas Cochrane, Ash Singhal, Paul Steinbok
DOI: 10.1007/s00381-011-1585-8
09/2011

Diffusion-weighted imaging and pathological correlation in pediatric medulloblastomas—“They are not always restricted!”
Child's Nervous System
Shibu Pillai, Ash Singhal, Angela T. Byrne, Chris Dunham, D. Douglas Cochrane, Paul Steinbok
DOI: 10.1007/s00381-011-1499-5
07/2011

Letter to the Editor: Right-left discrimination
Journal of Neurosurgery
David Cochrane
DOI: 10.3171/2010.10.jns101704
07/2011

Pediatric patients with poor neurological status and arteriovenous malformation hemorrhage: an outcome analysisClinical article
Journal of Neurosurgery: Pediatrics
Ash Singhal, Tara Adirim, Doug Cochrane, Paul Steinbok
DOI: 10.3171/2011.2.peds10355
05/2011

Letter to the Editor: Shunt failure
Journal of Neurosurgery: Pediatrics
D. Douglas Cochrane
DOI: 10.3171/2011.2.peds10445
05/2011

Third ventricular shape: a predictor of endoscopic third ventriculostomy success in pediatric patientsClinical article
Journal of Neurosurgery: Pediatrics
Mansoor Foroughi, Andrew Wong, Paul Steinbok, Ash Singhal, Michael A. Sargent, D. Douglas Cochrane
DOI: 10.3171/2011.1.peds10461
04/2011

Natural history of untreated syringomyelia in pediatric patients
Neurosurgical Focus
Ash Singhal, Tim Bowen-Roberts, Paul Steinbok, Doug Cochrane, Angela T. Byrne, John M. Kerr
DOI: 10.3171/2011.9.focus11208
2011

A Randomized Trial of Prenatal Versus Postnatal Repair of Myelomeningocele
Survey of Anesthesiology
N. Scott Adzick, Elizabeth A. Thom, Catherine Y. Spong, John W. Brock, Pamela K. Burrows, Mark P. Johnson, Lori J. Howell, Jody A. Farrell, Mary E. Dabrowiak, Leslie N. Sutton, Nalin Gupta, Noel B. Tulipan, Mary E. Dalton, Diana L. Farmer
DOI: 10.1097/sa.0b013e318237939e
2011

Microfibrillar collagen hemostat–induced necrotizing granulomatous inflammation developing after craniotomy: a pediatric case seriesReport of 3 cases
Journal of Neurosurgery: Pediatrics
Liat Apel-Sarid, Doug D. Cochrane, Paul Steinbok, Angela T. Byrne, Christopher Dunham
DOI: 10.3171/2010.8.peds10248
10/2010

Predicting who will benefit from endoscopic third ventriculostomy compared with shunt insertion in childhood hydrocephalus using the ETV Success ScoreClinical article
Journal of Neurosurgery: Pediatrics
Abhaya V. Kulkarni, James M. Drake, John R. W. Kestle, Conor L. Mallucci, Spyros Sgouros, Shlomi Constantini
DOI: 10.3171/2010.8.peds103
10/2010

Endoscopic Third Ventriculostomy Vs Cerebrospinal Fluid Shunt in the Treatment of Hydrocephalus in ChildrenA Propensity Score–Adjusted Analysis
Neurosurgery
Abhaya V. Kulkarni, James M. Drake, John R.W. Kestle, Conor L. Mallucci, Spyros Sgouros, Shlomi Constantini
DOI: 10.1227/01.neu.0000373199.79462.21
09/2010

Quality of life after endoscopic third ventriculostomy and cerebrospinal fluid shunting: an adjusted multivariable analysis in a large cohortClinical article
Journal of Neurosurgery: Pediatrics
Abhaya V. Kulkarni, Iffat Shams, D. Douglas Cochrane, P. Daniel McNeely
DOI: 10.3171/2010.3.peds09358
07/2010

A human factors and survey methodology-based design of a web-based adverse event reporting system for families
International Journal of Medical Informatics
Jeremy P. Daniels, Ashlee D. King, D. Douglas Cochrane, Roxane Carr, Nicola T. Shaw, Joanne Lim, J. Mark Ansermino
DOI: 10.1016/j.ijmedinf.2010.01.016
05/2010

Does treatment with endoscopic third ventriculostomy result in less concern among parents of children with hydrocephalus?
Child's Nervous System
Abhaya V. Kulkarni, Iffat Shams, D. Douglas Cochrane, P. Daniel McNeely
DOI: 10.1007/s00381-010-1162-6
04/2010

Time to listen: a review of methods to solicit patient reports of adverse events
Quality and Safety in Health Care
A. King, J. Daniels, J. Lim, D. D. Cochrane, A. Taylor, J. M. Ansermino
DOI: 10.1136/qshc.2008.030114
03/2010

Endoscopic Choroid Plexus Cauterization Versus Ventriculoperitoneal Shunt for Hydranencephaly and Near Hydranencephaly: A Prospective Study
Neurosurgery
José Augusto Malheiros, Felipe Padovani Trivelato, Marcelo Magaldi Oliveira, Sebastião Gusmão, David Douglas Cochrane, Paul Steinbok
DOI: 10.1227/01.neu.0000365264.99133.ca
03/2010

Hypothermia Therapy after Traumatic Brain Injury in Children
Yearbook of Pediatrics
J.A. Stockman
DOI: 10.1016/s0084-3954(09)79292-9
01/2010

Intracranial Suppuration
Controversies in Pediatric Neurosurgery
DOI: 10.1055/b-0034-80791
2010

Establishing a Provincial Patient Safety and Learning System: Pilot Project Results and Lessons Learned
Healthcare Quarterly
Doug Cochrane, Annemarie Taylor, Georgene Miller, Valoria Hait, Irene Matsui, Manish Bharadwaj, Patrick Devine
DOI: 10.12927/hcq.2009.20717
08/2009

Clinical, radiologic and pathologic features and outcome following surgery for cervicomedullary gliomas in children
Child's Nervous System
Salvatore Di Maio, Shahid M. Gul, D. Douglas Cochrane, Glenda Hendson, Michael A. Sargent, Paul Steinbok
DOI: 10.1007/s00381-009-0956-x
07/2009

Occipital Dermoid Cyst Associated with Dermal Sinus and Cerebellar Abscesses
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Gurdeep S. Mann, Ashok Gupta, D. Douglas Cochrane, Manraj K.S. Heran
DOI: 10.1017/s0317167100007848
07/2009

Bilateral choroid plexus hyperplasia: a case report and management strategies
Child's Nervous System
Daniel T. Warren, Glenda Hendson, David Douglas Cochrane
DOI: 10.1007/s00381-009-0923-6
06/2009

Predicting postresection hydrocephalus in pediatric patients with posterior fossa tumorsClinical article
Journal of Neurosurgery: Pediatrics
Jay Riva-Cambrin, Allan S. Detsky, Maria Lamberti-Pasculli, Michael A. Sargent, Derek Armstrong, Rahim Moineddin, D. Douglas Cochrane, James M. Drake
DOI: 10.3171/2009.1.peds08298
05/2009

A Randomized, Controlled Trial of the Impact of Early and Rapid Diagnosis of Viral Infections in Children Brought to an Emergency Department with Febrile Respiratory Tract Illnesses
The Journal of Pediatrics
Quynh H. Doan, Niranjan Kissoon, Simon Dobson, Sandy Whitehouse, Doug Cochrane, Brian Schmidt, Eva Thomas
DOI: 10.1016/j.jpeds.2008.07.043
01/2009

Conventional and Diffusion-Weighted Magnetic Resonance Imaging Findings in a Pediatric Patient with a Posterior Fossa Brain Tumor and Papilledema
Pediatric Neurosurgery
Kaivon Pakzad-Vaezi, Doug Cochrane, Michael Sargent, Ash Singhal
DOI: 10.1159/000270156
2009

Continuous Intrathecal Baclofen Treatment of Severe Spasms in Two Children with Spinal-cord Injury
Developmental Medicine & Child Neurology
Robert W. Armstrong, Paul Steinbok, Kevin Farrell, Doug Cochrane, Margaret G. Norman, Susan Kube
DOI: 10.1111/j.1469-8749.1992.tb11509.x
11/2008

Medical, Social, and Economic Factors Associated with Health-Related Quality of Life in Canadian Children with Hydrocephalus
The Journal of Pediatrics
Abhaya V. Kulkarni, D. Douglas Cochrane, P. Daniel McNeely, Iffat Shams
DOI: 10.1016/j.jpeds.2008.04.068
11/2008

A randomized clinical trial to compare selective posterior rhizotomy plus physiotherapy with physiotherapy alone in children with spastic diplegic cerebral palsy
Developmental Medicine & Child Neurology
Paul Steinbok, Ann M. Reiner, Richard Beauchamp, Robert W. Armstrong, D Douglas Cochrane
DOI: 10.1111/j.1469-8749.1997.tb07407.x
09/2008

Comparing children’s and parents’ perspectives of health outcome in paediatric hydrocephalus
Developmental Medicine & Child Neurology
Abhaya V Kulkarni, D Douglas Cochrane, P Daniel McNeely, Iffat Shams
DOI: 10.1111/j.1469-8749.2008.03037.x
08/2008

Resolution of syringomyelia and Chiari malformation after growth hormone therapy
Child's Nervous System
Ashok Gupta, Aleksander M. Vitali, Ralph Rothstein, D. Douglas Cochrane
DOI: 10.1007/s00381-008-0675-8
07/2008

Pediatric Neurosurgical Service Needs for Congenital Hydrocephalus and Spina Bifida in Canada: 2001–2005
Journal of Neurosurgery: Pediatrics
Douglas Cochrane
DOI: 10.3171/ped/2008/1/4/paper19
04/2008

Optic nerve sheath fenestration and bilateral expansile cranioplasty for raised intracranial pressure in craniometaphyseal dysplasia: a case report
Child's Nervous System
Ash Singhal, David D. Cochrane
DOI: 10.1007/s00381-007-0549-5
01/2008

Occult Spinal Dysraphism
Principles and Practice of Pediatric Neurosurgery, 2nd edition
DOI: 10.1055/b-0034-56399
2008

Intracranial Epidural and Subdural Infections
Principles and Practice of Pediatric Neurosurgery, 2nd edition
DOI: 10.1055/b-0034-56449
2008

Cord untethering for lipomyelomeningocele: expectation after surgery
Neurosurgical Focus
D. Douglas Cochrane
DOI: 10.3171/foc-07/08/e9
08/2007

Significance of beaten copper appearance on skull radiographs in children with isolated sagittal synostosis
Child's Nervous System
Deepak Agrawal, Paul Steinbok, D. Douglas Cochrane
DOI: 10.1007/s00381-007-0430-6
07/2007

Endoscopic Third Ventriculostomy in Pediatric Patients: The Canadian Experience
Neurosurgery
James M. Drake
DOI: 10.1227/01.neu.0000255420.78431.e7
05/2007

Progressive myelopathy due to meningeal thickening in shunted patients: description of a novel entity and the role of surgery
Child's Nervous System
Paul Steinbok, D. Douglas Cochrane
DOI: 10.1007/s00381-007-0347-0
05/2007

Ascites and abdominal pseudocysts following ventriculoperitoneal shunt surgery: variations of the same theme
Journal of Neurosurgery: Pediatrics
Rajeev Kariyattil, Paul Steinbok, Ashutosh Singhal, D. Douglas Cochrane
DOI: 10.3171/ped.2007.106.5.350
05/2007

Simple technique of head fixation for image-guided neurosurgery in infants
Child's Nervous System
D. Cochrane
DOI: 10.1007/s00381-007-0359-9
04/2007

Early hypodensity on computed tomographic scan of the brain in an accidental pediatric head injury
Neurosurgery
Paul Steinbok and Ashutosh Singhal and Ken Poskitt and D. Douglas Cochrane
DOI: 10.1227/01.neu.0000255398.00410.6b
04/2007

Reply to Dr. Rekate’s letter on the article “Etiologic differences between isolated lateral ventricle and the isolated fourth ventricle”
Child's Nervous System
Paul Steinbok, D. Douglas Cochrane, Ben Ti Ang
DOI: 10.1007/s00381-007-0306-9
03/2007

Long-term anthropometric outcomes following surgery for isolated sagittal craniosynostosis
Journal of Neurosurgery: Pediatrics
Deepak Agrawal, M.Ch., Paul Steinbok, D. Douglas Cochrane
DOI: 10.3171/ped.2006.105.5.357
11/2006

Cerebrospinal fluid (CSF) leak and pseudomeningocele formation after posterior fossa tumor resection in children: a retrospective analysis
Child's Nervous System
P. Steinbok, A. Singhal, J. Mills, D. D. Cochrane, A. V. Price
DOI: 10.1007/s00381-006-0234-0
09/2006

Management of shunt infections: a multicenter pilot study
Journal of Neurosurgery: Pediatrics
John R. W. Kestle, Hugh J. L. Garton, William E. Whitehead, James M. Drake, Abhaya V. Kulkarni, D. Douglas Cochrane, Cheryl Muszynski, Marion L. Walker
DOI: 10.3171/ped.2006.105.3.177
09/2006

Shunt insertion in the summer: is it safe?
Journal of Neurosurgery: Pediatrics
John R. W. Kestle, D. Douglas Cochrane, James M. Drake
DOI: 10.3171/ped.2006.105.3.165
09/2006

Presyrinx state
Journal of Neurosurgery: Pediatrics
Yee Chiung Gan, Douglas Cochrane
DOI: 10.3171/ped.2006.105.2.156
08/2006

Reformation of the sagittal suture following surgery for isolated sagittal craniosynostosis
Journal of Neurosurgery: Pediatrics
Deepak Agrawal, Paul Steinbok, D. Douglas Cochrane
DOI: 10.3171/ped.2006.105.2.115
08/2006

Traumatic retroclival epidural hematoma—a pediatric entity?
Child's Nervous System
Deepak Agrawal, D. Douglas Cochrane
DOI: 10.1007/s00381-006-0059-x
03/2006

Etiological differences between the isolated lateral ventricle and the isolated fourth ventricle
Child's Nervous System
Beng Ti Ang, Paul Steinbok, D. Douglas Cochrane
DOI: 10.1007/s00381-006-0046-2
02/2006

Pseudoclosure of Anterior Fontanelle by Wormian Bone in Isolated Sagittal Craniosynostosis
Pediatric Neurosurgery
Deepak Agrawal, Paul Steinbok, D. Douglas Cochrane
DOI: 10.1159/000091854
2006

Diagnosis of isolated sagittal synostosis: are radiographic studies necessary?
Child's Nervous System
Deepak Agrawal, Paul Steinbok, D. Douglas Cochrane
DOI: 10.1007/s00381-005-1243-0
09/2005

Scaphocephaly or Dolichocephaly?
Journal of Neurosurgery: Pediatrics
DOI: 10.3171/ped.2005.102.2.0253
03/2005

Minimizing blood transfusions in the surgical correction of coronal and metopic craniosynostosis
Child's Nervous System
Paul Steinbok, Navraj Heran, Tufan Hicdonmez, D.Douglas Cochrane, Angela Price
DOI: 10.1007/s00381-004-0972-9
05/2004

Conservative Neurosurgical Management of Intracranial Epidural Abscesses in Children
Neurosurgery
Navraj Singh Heran, Paul Steinbok, D. Douglas Cochrane
DOI: 10.1227/01.neu.0000084163.51521.58
10/2003

Ventricular shunting for hydrocephalus in children: patients, procedures, surgeons and institutions in English Canada, 1989–2001
Journal of Pediatric Surgery
D.D. Cochrane, J. Kestle
DOI: 10.1016/s0022-3468(03)00240-9
07/2003

A Cost-effectiveness Analysis of Endoscopic Third Ventriculostomy
Neurosurgery
Hugh J.L. Garton, John R.W. Kestle, D. Douglas Cochrane, Paul Steinbok
DOI: 10.1093/neurosurgery/52.6.1506
06/2003

Lack of benefit of endoscopic ventriculoperitoneal shunt insertion: a multicenter randomized trial
Journal of Neurosurgery
John R. W. Kestle, James M. Drake, D. Douglas Cochrane, Ruth Milner, Marion L. Walker, Rick Abbott, Frederick A. Boop, the Endoscopic Shunt Insertion Trial Participants
DOI: 10.3171/jns.2003.98.2.0284
02/2003

The Influence of Surgical Operative Experience on the Duration of First Ventriculoperitoneal Shunt Function and Infection
Pediatric Neurosurgery
D.D. Cochrane, J.R.W. Kestle
DOI: 10.1159/000070413
2003

Spontaneous Resolution of Calvarial Eosinophilic Granuloma in Children
Pediatric Neurosurgery
Marcelo Oliveira, Paul Steinbok, John Wu, Navraj Heran, Douglas Cochrane
DOI: 10.1159/000069828
2003

Mutism after Posterior Fossa Tumour Resection in Children: Incomplete Recovery on Long-Term Follow-Up
Pediatric Neurosurgery
Paul Steinbok, D. Douglas Cochrane, Richard Perrin, Angela Price
DOI: 10.1159/000072468
2003

Reduction of transfusion rates in the surgical correction of sagittal synostosis
Journal of Neurosurgery
Stephen Hentschel, Paul Steinbok, D. Douglas Cochrane, John Kestle
DOI: 10.3171/jns.2002.97.3.0503
09/2002

A Cost-effectiveness Analysis of Endoscopic Third Ventriculostomy
Neurosurgery
Hugh J.L. Garton, John R.W. Kestle, D. Douglas Cochrane, Paul Steinbok
DOI: 10.1097/00006123-200207000-00012
07/2002

Death after late failure of third ventriculostomy in childrenReport of three cases
Journal of Neurosurgery
Walter J. Hader, James Drake, Douglas Cochrane, Owen Sparrow, Edward S. Johnson, John Kestle
DOI: 10.3171/jns.2002.97.1.0211
07/2002

MR Quantification of Flow in Children with Vascular Malformations
Interventional Neuroradiology
K.J. Poskitt, T. Marotta, C. Haw, D. Cochrane, P. Steinbok
DOI: 10.1177/159101990100700304
09/2001

Clinical Outcomes that Fetal Surgery for Myelomeningocele Needs to Achieve
European Journal of Pediatric Surgery
D. D. Cochrane, B. Irwin, K. Chambers
DOI: 10.1055/s-2001-19738
2001

Spontaneous resolution and recurrence of a Chiari I malformation and associated syringomyeliaCase Report
Journal of Neurosurgery: Spine
John C. L. Sun, Paul Steinbok, D. Douglas Cochrane
DOI: 10.3171/spi.2000.92.2.0207
04/2000

The initial treatment of hydrocephalus: An assessment of surgeons' preference between third ventriculostomy and shunt insertion
Neurological Research
J. Kestle, D. Cochrane, R. Alisharan
DOI: 10.1080/01616412.2000.11741039
01/2000

The Patterns of Late Deterioration in Patients with Transitional Lipomyelomeningocele
European Journal of Pediatric Surgery
D. Cochrane, C. Finley, J. Kestle, P. Steinbok
DOI: 10.1055/s-2008-1072406
2000

Cervical Myelocystoceles and Meningoceles: Long-Term Follow-Up
Pediatric Neurosurgery
John C.L. Sun, Paul Steinbok, D. Douglas Cochrane
DOI: 10.1159/000028992
2000

Pediatric Peri-Insular Hemispherotomy
Pediatric Neurosurgery
J. Kestle, M. Connolly, D. Cochrane
DOI: 10.1159/000028896
2000

Long-Term Follow-Up Data from the Shunt Design Trial
Pediatric Neurosurgery
J. Kestle, J. Drake, R. Milner, C. Sainte-Rose, G. Cinalli, F. Boop, J. Piatt, S. Haines, S. Schiff, D. Cochrane, P. Steinbok, N. MacNeil
DOI: 10.1159/000055960
2000

Posterior Fossa Craniotomy: An Alternative to Craniectomy
Pediatric Neurosurgery
Paul Steinbok, D. Doug Cochrane
DOI: 10.1159/000028910
2000

Consultation with the Specialist: Brain Abscess
Pediatrics in Review
D. D. Cochrane
DOI: 10.1542/pir.20-6-209
06/1999

Does It Leak In or Does It Leak Out
Pediatric Neurosurgery
Ryojo Akagami, D. Douglas Cochrane
DOI: 10.1159/000028774
1999

Randomized Trial of Cerebrospinal Fluid Shunt Valve Design in Pediatric Hydrocephalus
Neurosurgery
James M. Drake, John R.W. Kestle, Ruth Milner, Giuseppe Cinalli, Frederick Boop, Joseph Piatt, Stephen Haines, Steven J. Schiff, D. Douglas Cochrane, Paul Steinbok, Nancy MacNeil
DOI: 10.1097/00006123-199808000-00068
08/1998

Functional Deterioration following Placode Untethering in Myelomeningocele
Pediatric Neurosurgery
D.D. Cochrane, S.R. Rassekh, P.N. Thiessen
DOI: 10.1159/000028621
1998

Intrathecally administered baclofen for treatment of children with spasticity of cerebral origin
Journal of Neurosurgery
Robert W. Armstrong, Paul Steinbok, D. Douglas Cochrane, Susan D. Kube, Susan E. Fife, Kevin Farrell
DOI: 10.3171/jns.1997.87.3.0409
09/1997

Effect of hyperventilation on regional cerebral blood flow in head-injured children
Critical Care Medicine
Peter Skippen, Michael Seear, Ken Poskitt, John Kestle, Doug Cochrane, Gail Annich, Jeffrey Handel
DOI: 10.1097/00003246-199708000-00031
08/1997

Acute Swelling of the Cerebellum in Childhood
Journal of Child Neurology
Juliette Hukin, Douglas D. Cochrane, John U. Crichton
DOI: 10.1177/088307389701200411
06/1997

Prenatal Spinal Evaluation and Functional Outcome of Patients Born With MyelomeningoceleInformation for Improved Counselling and Outcome Prediction
Obstetrical & Gynecological Survey
D. Douglas Cochrane, R. Douglas Wilson, Paul Steinbok, Duncan F. Farquharson, Beverly Irwin, Brandon Irvine, Keith Chambers
DOI: 10.1097/00006254-199611000-00005
11/1996

Value of postoperative surveillance imaging in the management of children with some common brain tumors
Journal of Neurosurgery
Paul Steinbok, Stephen Hentschel, D. Douglas Cochrane, John R. W. Kestle
DOI: 10.3171/jns.1996.84.5.0726
05/1996

The significance of bacteriologically positive ventriculoperitoneal shunt components in the absence of other signs of shunt infection
Journal of Neurosurgery
Paul Steinbok, D. Douglas Cochrane, John R. W. Kestle
DOI: 10.3171/jns.1996.84.4.0617
04/1996

Assessment of the Appropriateness of Services Provided by a Multidisciplinary Meningomyelocele Clinic
Pediatric Neurosurgery
Keith Chambers, Douglas Cochrane, Beverly Irwin, William Arnold, Paul N. Thiessen
DOI: 10.1159/000121023
1996

Prenatal Spinal Evaluation and Functional Outcome of Patients Born with Myelomeningocele: Information for Improved Prenatal Counselling and Outcome Prediction
Fetal Diagnosis and Therapy
Douglas Cochrane, Douglas Wilson, Paul Steinbok, Duncan F. Farquharson, Beverly Irwin, Brandon Irvine, Keith Chambers
DOI: 10.1159/000264297
1996

Recurrent Compression of Chiari Malformation
Pediatric Neurosurgery
D.D. Cochrane
DOI: 10.1159/000121053
1996

Radiographic Imaging Requirements following Ventriculoperitoneal Shunt Procedures
Pediatric Neurosurgery
Paul Steinbok, Michael Boyd, Olof Flodmark, Douglas Cochrane
DOI: 10.1159/000120892
1995

Cervical Meningoceles and Myelocystoceles: A Unifying Hypothesis
Pediatric Neurosurgery
Paul Steinbok, Douglas Cochrane
DOI: 10.1159/000120978
1995

Model for the Cost Analysis of Shunted Hydrocephalic Children
Pediatric Neurosurgery
D.D. Cochrane, J. Kestle, P. Steinbok, D. Evans, N. Heron
DOI: 10.1159/000120930
1995

Acute Subdural Hematoma Associated with Cerebral Infarction in the Full-Term Neonate
Pediatric Neurosurgery
P. Steinbok, C.S. Haw, D.D. Cochrane, J.R.W. Kestle
DOI: 10.1159/000120960
1995

Ventriculosubgaleal shunt in the management of recurrent ventriculoperitoneal shunt infection
Child's Nervous System
Paul Steinbok, D. Douglas Cochrane
DOI: 10.1007/bf00335079
11/1994

The validity of electrophysiological criteria used in selective functional posterior rhizotomy for treatment of spastic cerebral palsy
Journal of Neurosurgery
Paul Steinbok, Robert Keyes, Lisa Langill, D. Douglas Cochrane
DOI: 10.3171/jns.1994.81.3.0354
09/1994

Prevention of Postshunting Ventricular Asymmetry by Transseptal Placement of Ventricular Catheters
Pediatric Neurosurgery
Paul Steinbok, Ken J. Poskitt, Douglas D. Cochrane, John R.W. Kestle
DOI: 10.1159/000120816
1994

The Surgical and Natural Morbidity of Aggressive Resection for Posterior Fossa Tumors in Childhood
Pediatric Neurosurgery
D. Douglas Cochrane, Bengt Gustavsson, Kenneth P. Poskitt, Paul Steinbok, John R.W. Kestle
DOI: 10.1159/000120761
1994

Cytogenetic analysis of 109 pediatric central nervous system tumors
Cancer Genetics and Cytogenetics
Etela Neumann, Dagmar K. Kalousek, Margaret G. Norman, Paul Steinbok, D.Douglas Cochrane, Karen Goddard
DOI: 10.1016/0165-4608(93)90200-6
11/1993

Visual Evoked Potentials and Intracranial Pressure-Reply
Archives of Neurology
M. B. Connolly, J. E. Jan, D. D. Cochrane
DOI: 10.1001/archneur.1992.00530350021011
11/1992

Observations on electrical stimulation of lumbosacral nerve roots in children with and without lower limb spasticity
Child's Nervous System
Paul Steinbok, Lisa Langill, D. Douglas Cochrane, Robert Keyes
DOI: 10.1007/bf00304784
10/1992

Laminotomy: a technical note
Child's Nervous System
D. Douglas Cochrane, Paul Steinbok
DOI: 10.1007/bf00262853
06/1992

Long-term outcome and complications of children born with meningomyelocele
Child's Nervous System
Paul Steinbok, Brendon Irvine, D. Douglas Cochrane, Beverly J. Irwin
DOI: 10.1007/bf00298448
03/1992

Removal of Adherent Ventricular Catheter
Pediatric Neurosurgery
Paul Steinbok, Douglas Cochrane
DOI: 10.1159/000120658
1992

The Use of Hypermedia for Parent Education in Pediatric Neurosurgery
Pediatric Neurosurgery
Douglas Cochrane, E. Durbach, P. Steìnbok
DOI: 10.1159/000120684
1992

Selective Functional Posterior Rhizotomy for Treatment of Spastic Cerebral Palsy in Children
Pediatric Neurosurgery
Paul Steinbok, Ann Reiner, Richard D. Beauchamp, Douglas D. Cochrane, Robert Keyes
DOI: 10.1159/000120639
1992

The effects of labor and delivery on spinal cord function and ambulation in patients with meningomyelocele
Child's Nervous System
D. Cochrane, K. Aronyk, B. Sawatzky, D. Wilson, P. Steinbok
DOI: 10.1007/bf00304828
10/1991

Rapid Recovery From Cortical Visual Impairment Following Correction of Prolonged Shunt Malfunction in Congenital Hydrocephalus
Archives of Neurology
M. B. Connolly, J. E. Jan, D. D. Cochrane
DOI: 10.1001/archneur.1991.00530210082028
09/1991

The nature of congenital posterior cervical or cervicothoracic midline cutaneous mass lesionsReport of eight cases
Journal of Neurosurgery
Paul Steinbok, D. Douglas Cochrane
DOI: 10.3171/jns.1991.75.2.0206
08/1991

Surgical Implications of Cerebral Dysgenesis
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
D. Douglas Cochrane, K.J. Poskitt, M.G. Norman
DOI: 10.1017/s0317167100031656
05/1991

Early computed tomographic scanning after resection of brain tumors in children
Child's Nervous System
Paul Steinbok, Ken Poskitt, D. Douglas Cochrane, O. Olof Flodmark
DOI: 10.1007/bf00263826
02/1991

Apnea in Patients with Myelomeningocele
Pediatric Neurosurgery
D.D. Cochrane, R. Adderley, C.P. White, M. Norman, P. Steinbok
DOI: 10.1159/000120533
1990

Cervical Neuroschisis and Meningocoele Manque in Type I (No Neck) Klippel-Feil Syndrome
Pediatric Neurosurgery
D.D. Cochrane, R.H.A. Haslam, S.T. Myles
DOI: 10.1159/000120520
1990

Ruptured Intracranial Aneurysm Presenting as Cerebral Infarction in a Young Child
Pediatric Neurosurgery
A.M. Rojiani, K.J. Poskitt, D.D. Cochrane, A.J. Macnab, M.G. Norman
DOI: 10.1159/000120553
1990

Keyhole craniectomy for correction of sagittal synostosis
Child's Nervous System
Michael W. McDermott, Paul Steinbok, Douglas D. Cochrane
DOI: 10.1007/bf00706751
02/1989

Cervical spinal deformity following craniotomy and upper cervical laminectomy for posterior fossa tumors in children
Child's Nervous System
Paul Steinbok, Michael Boyd, Douglas Cochrane
DOI: 10.1007/bf00706742
02/1989

Spontaneous Remission of Paralysis Due to Spinal Extradural Hematoma: Case Report
Neurosurgery
D. J. Emery, D. D. Cochrane
DOI: 10.1227/00006123-198812000-00015
1988

Visual evoked potentials, intracranial pressure and ventricular size in hydrocephalus
Documenta Ophthalmologica
StuartG. Coupland, D.Douglas Cochrane
DOI: 10.1007/bf00213660
08/1987

Maturational topography of the visual evoked potential in fetal lambs
Documenta Ophthalmologica
StuartG. Coupland, D.Douglas Cochrane
DOI: 10.1007/bf00213662
08/1987

Neurotoxic complications of contrast computed tomography in children
The Journal of Pediatrics
Robert H.A. Haslam, D. Douglas Cochrane, Gary M. Amundson, Robert D. Johns
DOI: 10.1016/s0022-3476(87)80197-x
1987

Intrauterine Hydrocephalus and Ventriculomegaly: Associated Abnomalies and Fetal Outcome
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
D. D. Cochrane, S. T. Myles, C. Nimrod, D. K. Still, R. G. Sugarman, B. K. Wittmann
DOI: 10.1017/s031716710004659x
02/1985

Management of Acute Subdural Hematomas from Aneurysmal Rupture
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Bryce Weir, Terence Myles, Moe Kahn, Falah Maroun, David Malloy, Brien Benoit, Michael McDermott, Douglas Cochrane, Gerard Mohr, Gary Ferguson, Felix Durity
DOI: 10.1017/s031716710004573x
08/1984

Timing of surgery for intracerebral hematomas due to aneurysm rupture
Journal of Neurosurgery
Brian Wheelock, Bryce Weir, Reginald Watts, Gerard Mohr, Moe Khan, Michael Hunter, Derek Fewer, Gary Ferguson, Felix Durity, Douglas Cochrane, Brien Benoit
DOI: 10.3171/jns.1983.58.4.0476
04/1983

Clinical – Radiological Correlates in Intracerebral Hematomas due to Aneurysmal Rupture
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
B.G. Benoit, D.D. Cochrane, F. Durity, G.G. Ferguson, D. Fewer, K.M. Hunter, M.I. Khan, G. Mohr, A.R. Watts, B.K.A. Weir, W.B. Wheelock
DOI: 10.1017/s0317167100044310
11/1982

Management of intrauterine hydrocephalus
Journal of Neurosurgery
David D. Cochrane, S. Terence Myles
DOI: 10.3171/jns.1982.57.5.0590
11/1982

Spasticity in Spina Bifida
The Spina Bifida
David Douglas Cochrane and Richard Beauchamp and Carol King and Andrew MacNeily
DOI: 10.1007/978-88-470-0651-5_24

Research

Current Projects
Using CNS imaging technologies to define physiological parameters as they apply to infants and children with hydrocephalus, the directions being taken at the present include the development of techniques to describe the morphological changes in the ventricular system that occur as a result of ventricular shunting or third ventriculostomy. This is based imaging and 3D morphometric analysis. It is also anticipated that MR imaging, using time gated sequences or tensor imaging will allow non-invasive assessments of intracranial compliance. Using such non-invasive measures will assist in the determination of optimal shunting for children with hydrocephalus. This work applies computational fluid dynamic and finite element analysis techniques to biological problems.

Health care programme development, evaluation and service planning are fundamental to the provision of optimal care. Within the discipline of pediatric neurosurgery, the geographical diversity of the western provinces and the limitations imposed by available subspeciality staff and equipment force the evaluation of operative services from the perspecitve of patient care and health economics. Studies have been completed describing the influence of surgeon experience on shunt failure rates in hydrocephalic patients and on the epidemiology of pediatric neurosurgical practice in Western Canada . Similar analyses are applicable to other low frequency, high risk areas such as cardiac surgery.

Improving the quality of care for children with pediatric neurosurgical problems can be approached from the perspective of hypothesis-based studies or by the application of knowledge already known. To apply either effectively, coordinated, structured and focused collaboratives are required. Due to the low frequency and the high risk of conditions treated by pediatric neurosurgeons, a network is being developed to build on the successful Pediatric Neurosurgery Study Group through the application of quality monitoring and improvement techniques.

Spina bifida is the commonest multisystem congenital anomaly seen in humans. The evaluation of interventions is critically important in optimizing patient function and developmental outcomes. Clinical problems studied in this population include the role of elective caesarian section as an attempt to minimize neurological defects and the role of cord untethering as a tool to maximize spinal function in the child. Lipomylemeningocele (lipoma of the conus) patients have been reviewed and the long-term outcome has been quantified and clarified. Programme evaluations have been performed for the benefit of our multidisciplinary clinic and patients .

Compression of the spinal cord by tumours, congenital malformations and bone abnormalities is devastating for patients, as the possibility for permanent paralysis affecting the arms, legs, breathing, bladder, bowel and sexual functions are high. Compression is particularly dangerous when if occurs at the top of the spinal canal. The Departments of Orthopedics and Neurosurgery (Cochrane) have a special interest and expertise in correcting spinal cord and lower brain compression. This special interest involves patients with Morquio's syndrome, achondroplasia and other forms of osteodysplasia.

My current projects include:

Development of a systematic patient prioritization and scheduling tool
Children's cancer: access to care - surgical services prioritization
The determinants of health in children with hydrocephalus

Research Group Members

Helen McGregor