Overview

Normal fetal growth and development is a complex process with many points at which abnormality may occur. Triploidy and other chromosome abnormalities occur frequently in early pregnancy. Study of triploidy affords insights into the normal processes involved in successful pregnancy and ways in which those processes may be affected by chromosome abnormality. Study of triploid pregnancies yields information on intrauterine growth retardation, imprinting processes in placenta, function of the placenta and its component parts, and reasons for pregnancy losses.

Publications

Pervasive polymorphic imprinted methylation in the human placenta.
Hanna CW and Peñaherrera MS and Saadeh H and Andrews S and McFadden DE and Kelsey G and Robinson WP
DOI: 10.1101/gr.196139.115
PubMed: 26769960
06/2016

Profiling placental and fetal DNA methylation in human neural tube defects.
Price EM and Peñaherrera MS and Portales-Casamar E and Pavlidis P and Van Allen MI and McFadden DE and Robinson WP
DOI: 10.1186/s13072-016-0054-8
PubMed: 26889207
2016

Recurrent triploidy due to a failure to complete maternal meiosis II: whole-exome sequencing reveals candidate variants.
Filges I and Manokhina I and Peñaherrera MS and McFadden DE and Louie K and Nosova E and Friedman JM and Robinson WP
DOI: 10.1093/molehr/gau112
PubMed: 25504873
04/2015

Anterolateral diaphragmatic hernia with body wall defect understood in relation to the abaxial domain.
Lehman AM and Cowan JR and McFadden DE and Patel MS
DOI: 10.1002/ajmg.a.36529
PubMed: 24700809
07/2014

Overlapping DNA methylation profile between placentas with trisomy 16 and early-onset preeclampsia.
Blair JD and Langlois S and McFadden DE and Robinson WP
DOI: 10.1016/j.placenta.2014.01.001
PubMed: 24462402
03/2014

Chorioamnionitis in the pathogenesis of brain injury in preterm infants.
Chau V and McFadden DE and Poskitt KJ and Miller SP
DOI: 10.1016/j.clp.2013.10.009
PubMed: 24524448
03/2014

Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia.
Blair JD and Yuen RK and Lim BK and McFadden DE and von Dadelszen P and Robinson WP
DOI: 10.1093/molehr/gat044
PubMed: 23770704
10/2013

Prenatal and postnatal inflammation in relation to cortisol levels in preterm infants at 18 months corrected age.
Gover A and Chau V and Miller SP and Brant R and McFadden DE and Poskitt KJ and Synnes A and Weinberg J and Grunau RE
DOI: 10.1038/jp.2013.24
PubMed: 23558431
08/2013

Maternal NLRP7 and C6orf221 variants are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage.
Manokhina I and Hanna CW and Stephenson MD and McFadden DE and Robinson WP
DOI: 10.1093/molehr/gat019
PubMed: 23515668
08/2013

Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.
Hogg K and Blair JD and McFadden DE and von Dadelszen P and Robinson WP
DOI: 10.1371/journal.pone.0062969
PubMed: 23667551
2013

Protein kinase profiling in miscarriage: implications for the pathogenesis of trisomic pregnancy.
Yong PJ and McFadden DE and Robinson WP
PubMed: 23231796
12/2012

Carnitine palmitoyltransferase I and sudden unexpected infant death in British Columbia First Nations.
Sinclair GB and Collins S and Popescu O and McFadden D and Arbour L and Vallance HD
DOI: 10.1542/peds.2011-2924
PubMed: 23090344
11/2012

Different measures of "genome-wide" DNA methylation exhibit unique properties in placental and somatic tissues.
Price EM and Cotton AM and Peñaherrera MS and McFadden DE and Kobor MS and Robinson W
DOI: 10.4161/epi.20221
PubMed: 22531475
06/2012

Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care.
Chang BA and Huang Q and Quan J and Chau V and Ladd M and Kwan E and McFadden DE and Lacaze-Masmonteil T and Miller SP and Lavoie PM
DOI: 10.1016/j.cyto.2011.08.028
PubMed: 21940177
12/2011

Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation.
Cotton AM and Lam L and Affleck JG and Wilson IM and Peñaherrera MS and McFadden DE and Kobor MS and Lam WL and Robinson WP and Brown CJ
DOI: 10.1007/s00439-011-1007-8
PubMed: 21597963
08/2011

Developmental origin of chorionic villus cultures from spontaneous abortion and chorionic villus sampling.
Yong PJ and McFadden DE and Robinson WP
PubMed: 21639964
05/2011

The utility of quantitative methylation assays at imprinted genes for the diagnosis of fetal and placental disorders.
Bourque DK and Peñaherrera MS and Yuen RK and Van Allen MI and McFadden DE and Robinson WP
DOI: 10.1111/j.1399-0004.2010.01443.x
PubMed: 20507345
02/2011

Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies.
Yuen RK and Jiang R and Peñaherrera MS and McFadden DE and Robinson WP
DOI: 10.1186/1756-8935-4-10
PubMed: 21749726
2011

Extensive epigenetic reprogramming in human somatic tissues between fetus and adult.
Yuen RK and Neumann SM and Fok AK and Peñaherrera MS and McFadden DE and Robinson WP and Kobor MS
DOI: 10.1186/1756-8935-4-7
PubMed: 21545704
2011

DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia.
Yuen RK and Peñaherrera MS and von Dadelszen P and McFadden DE and Robinson WP
DOI: 10.1038/ejhg.2010.63
PubMed: 20442742
09/2010

Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction.
Robinson WP and Peñaherrera MS and Jiang R and Avila L and Sloan J and McFadden DE and Langlois S and von Dadelszen P
DOI: 10.1002/pd.2597
PubMed: 19918961
01/2010

Effect of chorioamnionitis on brain development and injury in premature newborns.
Chau V and Poskitt KJ and McFadden DE and Bowen-Roberts T and Synnes A and Brant R and Sargent MA and Soulikias W and Miller SP
DOI: 10.1002/ana.21713
PubMed: 19743455
08/2009

Placental weight in pregnancies with trisomy confined to the placenta.
Yong PJ and von Dadelszen P and McFadden DE and Barrett IJ and Kalousek DK and Robinson WP
PubMed: 19761633
07/2009

Congenital gliosarcoma: detailed clinicopathologic documentation of a rare neoplasm.
Hocwald O and McFadden D and Osiovich H and Dunham C
DOI: 10.2350/09-01-0592-oa.1
PubMed: 19883237
2009

De novo mutation of the DHCR7 gene in a fetus with severe Smith-Lemli-Opitz (or RSH) syndrome.
Waye JS and Eng B and Potter MA and Nowaczyk MJ and McFadden D and Langlois S
DOI: 10.1002/ajmg.a.31802
PubMed: 17595012
08/2007

Renal-hepatic-pancreatic dysplasia: an autosomal recessive condition that is not linked to the PKHD1 gene on chromosome 6p21.1-p12.
Schrader KA and Nelson TN and McFadden DE and Pantzar T and Langlois S
DOI: 10.1002/ajmg.a.31818
PubMed: 17593545
08/2007

Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15.5.
Robinson WP and Slee J and Smith N and Murch A and Watson SK and Lam WL and McFadden DE
DOI: 10.1002/ajmg.a.31800
PubMed: 17593542
08/2007

Origin and outcome of pregnancies affected by androgenetic/biparental chimerism.
Robinson WP and Lauzon JL and Innes AM and Lim K and Arsovska S and McFadden DE
DOI: 10.1093/humrep/del462
PubMed: 17185351
04/2007

Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage.
Hirschfeld AF and Jiang R and Robinson WP and McFadden DE and Turvey SE
DOI: 10.1093/humrep/del377
PubMed: 16982657
02/2007

Phenotype of triploid embryos.
McFadden DE and Robinson WP
DOI: 10.1136/jmg.2005.037747
PubMed: 16236813
07/2006

Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia.
Kaiser-Rogers KA and McFadden DE and Livasy CA and Dansereau J and Jiang R and Knops JF and Lefebvre L and Rao KW and Robinson WP
DOI: 10.1136/jmg.2005.033571
PubMed: 15908568
02/2006

Immunolocalization of estrogen receptor alpha and beta in human fetal prostate.
Shapiro E and Huang H and Masch RJ and McFadden DE and Wilson EL and Wu XR
DOI: 10.1097/01.ju.0000176472.90432.5b
PubMed: 16217392
11/2005

The prostatic utricle is not a Mullerian duct remnant: immunohistochemical evidence for a distinct urogenital sinus origin.
Shapiro E and Huang H and McFadden DE and Masch RJ and Ng E and Lepor H and Wu XR
DOI: 10.1097/01.ju.0000140267.46772.7d
PubMed: 15371806
10/2004

Dispermy--origin of diandric triploidy: brief communication.
McFadden DE and Jiang R and Langlois S and Robinson WP
DOI: 10.1093/humrep/17.12.3037
PubMed: 12456599
12/2002

Maternal serum screening in triploidy.
McFadden DE and Hulait G and Lockitch G and Langlois S
DOI: 10.1002/pd.477
PubMed: 12454969
12/2002

Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism.
Robinson WP and McFadden DE and Barrett IJ and Kuchinka B and Peñaherrera MS and Bruyère H and Best RG and Pedreira DA and Langlois S and Kalousek DK
DOI: 10.1002/pd.483
PubMed: 12454962
12/2002

The origin of abnormalities in recurrent aneuploidy/polyploidy.
Robinson WP and McFadden DE and Stephenson MD
DOI: 10.1086/324468
PubMed: 11675616
12/2001

Recurrent trisomy 15 in a female carrier of der(15)t(Y;15)(q12;p13).
Rajcan-Separovic E and Robinson WP and Stephenson M and Pantzar T and Arbour L and McFadden D and Guscott J
DOI: 10.1002/1096-8628(2001)9999:9999<::aid-ajmg1173>3.0.co;2-1
PubMed: 11252000
04/2001

Parental and meiotic origin of triploidy in the embryonic and fetal periods.
McFadden DE and Langlois S
DOI: 10.1034/j.1399-0004.2000.580306.x
PubMed: 11076041
09/2000

Gonadal pathology in triploidy.
McFadden DE and Pantzar JT and Jevon GP
DOI: 10.1007/s100240010114
PubMed: 11000332
2000

Frequency of meiotic trisomy depends on involved chromosome and mode of ascertainment.
Robinson WP and Bernasconi F and Lau A and McFadden DE
DOI: 10.1002/(sici)1096-8628(19990507)84:13.3.co;2-z
PubMed: 10213044
05/1999

A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.
Knezevich SR and McFadden DE and Tao W and Lim JF and Sorensen PH
DOI: 10.1038/ng0298-184
PubMed: 9462753
02/1998

Chromosome abnormalities in human beings.
McFadden DE and Friedman JM
DOI: 10.1016/s0027-5107(97)00179-6
PubMed: 9434864
12/1997

Renal tubular dysgenesis with calvarial hypoplasia: report of two additional cases and review.
McFadden DE and Pantzar JT and Van Allen MI and Langlois S
DOI: 10.1136/jmg.34.10.846
PubMed: 9350819
10/1997

Pleural relapse during hematopoietic remission in childhood acute lymphoblastic leukemia.
Dix DB and Anderson RA and McFadden DE and Wadsworth LD
DOI: 10.1097/00043426-199709000-00013
PubMed: 9329473
1997

Precise localisation of 3p25 breakpoints in four patients with the 3p-syndrome.
Drumheller T and McGillivray BC and Behrner D and MacLeod P and McFadden DE and Roberson J and Venditti C and Chorney K and Chorney M and Smith DI
DOI: 10.1136/jmg.33.10.842
PubMed: 8933338
10/1996

Comparison of phenotype in uniparental disomy and deletion Prader-Willi syndrome: sex specific differences.
Mitchell J and Schinzel A and Langlois S and Gillessen-Kaesbach G and Schuffenhauer S and Michaelis R and Abeliovich D and Lerer I and Christian S and Guitart M and McFadden DE and Robinson WP
DOI: 10.1002/(sici)1096-8628(19961016)65:23.0.co;2-r
PubMed: 8911605
10/1996

Placental pathology of triploidy.
McFadden DE and Pantzar JT
DOI: 10.1016/s0046-8177(96)90277-4
PubMed: 8892584
10/1996

Research

Current Projects
To study X inactivation in early triploid pregnancy losses and to assess correlation of parental origin of triploidy and embryonic/placental phenotype in early pregnancy losses.

Current Projects
To diagnose the underlying defect in miscarriages that have a cytogenetically normal karyotype, and to compare genetic abnormalities in pregnancies conceived naturally with those conceived by IVF.