Scientists have developed a molecular “clock” that could reshape how pediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders. The research, published this week in PNAS, describes how the addition of chemical tags to DNA over time can potentially be used to screen for developmental differences and health problems in children.
Normal fetal growth and development is a complex process with many points at which abnormality may occur. Triploidy and other chromosome abnormalities occur frequently in early pregnancy. Study of triploidy affords insights into the normal processes involved in successful pregnancy and ways in which those processes may be affected by chromosome abnormality. Study of triploid pregnancies yields information on intrauterine growth retardation, imprinting processes in placenta, function of the placenta and its component parts, and reasons for pregnancy losses.
Pervasive polymorphic imprinted methylation in the human placenta.
Hanna CW and Peñaherrera MS and Saadeh H and Andrews S and McFadden DE and Kelsey G and Robinson WP
Profiling placental and fetal DNA methylation in human neural tube defects.
Price EM and Peñaherrera MS and Portales-Casamar E and Pavlidis P and Van Allen MI and McFadden DE and Robinson WP
Recurrent triploidy due to a failure to complete maternal meiosis II: whole-exome sequencing reveals candidate variants.
Filges I and Manokhina I and Peñaherrera MS and McFadden DE and Louie K and Nosova E and Friedman JM and Robinson WP
Anterolateral diaphragmatic hernia with body wall defect understood in relation to the abaxial domain.
Lehman AM and Cowan JR and McFadden DE and Patel MS
Overlapping DNA methylation profile between placentas with trisomy 16 and early-onset preeclampsia.
Blair JD and Langlois S and McFadden DE and Robinson WP
Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia.
Blair JD and Yuen RK and Lim BK and McFadden DE and von Dadelszen P and Robinson WP
Maternal NLRP7 and C6orf221 variants are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage.
Manokhina I and Hanna CW and Stephenson MD and McFadden DE and Robinson WP
Prenatal and postnatal inflammation in relation to cortisol levels in preterm infants at 18 months corrected age.
Gover A and Chau V and Miller SP and Brant R and McFadden DE and Poskitt KJ and Synnes A and Weinberg J and Grunau RE
Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.
Hogg K and Blair JD and McFadden DE and von Dadelszen P and Robinson WP
Protein kinase profiling in miscarriage: implications for the pathogenesis of trisomic pregnancy.
Yong PJ and McFadden DE and Robinson WP
Carnitine palmitoyltransferase I and sudden unexpected infant death in British Columbia First Nations.
Sinclair GB and Collins S and Popescu O and McFadden D and Arbour L and Vallance HD
Different measures of "genome-wide" DNA methylation exhibit unique properties in placental and somatic tissues.
Price EM and Cotton AM and Peñaherrera MS and McFadden DE and Kobor MS and Robinson W
Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care.
Chang BA and Huang Q and Quan J and Chau V and Ladd M and Kwan E and McFadden DE and Lacaze-Masmonteil T and Miller SP and Lavoie PM
Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation.
Cotton AM and Lam L and Affleck JG and Wilson IM and Peñaherrera MS and McFadden DE and Kobor MS and Lam WL and Robinson WP and Brown CJ
Developmental origin of chorionic villus cultures from spontaneous abortion and chorionic villus sampling.
Yong PJ and McFadden DE and Robinson WP
The utility of quantitative methylation assays at imprinted genes for the diagnosis of fetal and placental disorders.
Bourque DK and Peñaherrera MS and Yuen RK and Van Allen MI and McFadden DE and Robinson WP
Extensive epigenetic reprogramming in human somatic tissues between fetus and adult.
Yuen RK and Neumann SM and Fok AK and Peñaherrera MS and McFadden DE and Robinson WP and Kobor MS
Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies.
Yuen RK and Jiang R and Peñaherrera MS and McFadden DE and Robinson WP
DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia.
Yuen RK and Peñaherrera MS and von Dadelszen P and McFadden DE and Robinson WP
Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction.
Robinson WP and Peñaherrera MS and Jiang R and Avila L and Sloan J and McFadden DE and Langlois S and von Dadelszen P
Effect of chorioamnionitis on brain development and injury in premature newborns.
Chau V and Poskitt KJ and McFadden DE and Bowen-Roberts T and Synnes A and Brant R and Sargent MA and Soulikias W and Miller SP
Placental weight in pregnancies with trisomy confined to the placenta.
Yong PJ and von Dadelszen P and McFadden DE and Barrett IJ and Kalousek DK and Robinson WP
De novo mutation of the DHCR7 gene in a fetus with severe Smith-Lemli-Opitz (or RSH) syndrome.
Waye JS and Eng B and Potter MA and Nowaczyk MJ and McFadden D and Langlois S
Renal-hepatic-pancreatic dysplasia: an autosomal recessive condition that is not linked to the PKHD1 gene on chromosome 6p21.1-p12.
Schrader KA and Nelson TN and McFadden DE and Pantzar T and Langlois S
Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15.5.
Robinson WP and Slee J and Smith N and Murch A and Watson SK and Lam WL and McFadden DE
Origin and outcome of pregnancies affected by androgenetic/biparental chimerism.
Robinson WP and Lauzon JL and Innes AM and Lim K and Arsovska S and McFadden DE
Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage.
Hirschfeld AF and Jiang R and Robinson WP and McFadden DE and Turvey SE
Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia.
Kaiser-Rogers KA and McFadden DE and Livasy CA and Dansereau J and Jiang R and Knops JF and Lefebvre L and Rao KW and Robinson WP
Immunolocalization of estrogen receptor alpha and beta in human fetal prostate.
Shapiro E and Huang H and Masch RJ and McFadden DE and Wilson EL and Wu XR
The prostatic utricle is not a Mullerian duct remnant: immunohistochemical evidence for a distinct urogenital sinus origin.
Shapiro E and Huang H and McFadden DE and Masch RJ and Ng E and Lepor H and Wu XR
Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism.
Robinson WP and McFadden DE and Barrett IJ and Kuchinka B and Peñaherrera MS and Bruyère H and Best RG and Pedreira DA and Langlois S and Kalousek DK
Recurrent trisomy 15 in a female carrier of der(15)t(Y;15)(q12;p13).
Rajcan-Separovic E and Robinson WP and Stephenson M and Pantzar T and Arbour L and McFadden D and Guscott J
Frequency of meiotic trisomy depends on involved chromosome and mode of ascertainment.
Robinson WP and Bernasconi F and Lau A and McFadden DE
Renal tubular dysgenesis with calvarial hypoplasia: report of two additional cases and review.
McFadden DE and Pantzar JT and Van Allen MI and Langlois S
Pleural relapse during hematopoietic remission in childhood acute lymphoblastic leukemia.
Dix DB and Anderson RA and McFadden DE and Wadsworth LD
Precise localisation of 3p25 breakpoints in four patients with the 3p-syndrome.
Drumheller T and McGillivray BC and Behrner D and MacLeod P and McFadden DE and Roberson J and Venditti C and Chorney K and Chorney M and Smith DI
Comparison of phenotype in uniparental disomy and deletion Prader-Willi syndrome: sex specific differences.
Mitchell J and Schinzel A and Langlois S and Gillessen-Kaesbach G and Schuffenhauer S and Michaelis R and Abeliovich D and Lerer I and Christian S and Guitart M and McFadden DE and Robinson WP
To study X inactivation in early triploid pregnancy losses and to assess correlation of parental origin of triploidy and embryonic/placental phenotype in early pregnancy losses.
To diagnose the underlying defect in miscarriages that have a cytogenetically normal karyotype, and to compare genetic abnormalities in pregnancies conceived naturally with those conceived by IVF.