David Wright
PhD
Investigator, BC Children's Hospital
Lab Animal
Annalaura Bellucci and Bradley J. Baranowski and David C. Wright
DOI: 10.1038/s41684-026-01696-803 / 2026
Experimental Physiology
Annalaura Bellucci and Bradley J. Baranowski and Stewart Jeromson and Michael Akcan and Serena Trang and Meagan Arbeau and Hadil Alfares and Katelyn Eisner and David C. Wright
DOI: 10.1113/EP09275406 / 2025
Translational Exercise Biomedicine
Michael Akcan and David C. Wright
DOI: 10.1515/teb-2025-001606 / 2025
American Journal of Physiology Cell Physiology
Islam, H. and Jackson, G.S. and Boultbee, J. and Tsai, S.-H. and Moreno-Caba{\~n}as, A. and de Souza Teixeira, A.A. and Wright, D.C. and Mui, A.L. and Little, J.P.
DOI: 10.1152/ajpcell.00124.2025Journal of Physiology
Jeromson, S. and Baranowski, B. and Akcan, M. and Waters, B.D. and Eisner, K. and Bellucci, A. and Trang, S. and Abolhassani, A. and Tello-Palencia, M.A. and Schweitzer, A. and Stefanska, B. and Mitchell, C.J. and Wright, D.C.
DOI: 10.1113/JP289449Biorxiv
Asgariroozbehani, R. and Singh, R. and Wu, S. and Imami, A.S. and Hamoud, A.-R. and Agarwal, S.M. and Baranowski, B.J. and Jeromson, S. and Bernardo, A. and Prevot, T.D. and Wright, D.C. and Giacca, A. and McCullumsmith, R.E. and Pereira, S. and Hahn, M.K.
DOI: 10.1101/2025.04.11.648424Nature Metabolism
Townsend, L.K. and Wang, D. and Knuth, C.M. and Fayyazi, R. and Mohammad, A. and Becker, L.J. and Tsakiridis, E.E. and Desjardins, E.M. and Patel, Z. and Valvano, C.M. and Lu, J. and Payne, A.E. and Itua, O. and Medak, K.D. and Marko, D.M. and Schertzer, J.D. and Wright, D.C. and Beaudette, S.M. and Morrison, K.M. and Carpentier, A.C. and Blondin, D.P. and MacPherson, R.E.K. and McCall, J.G. and Jeschke, M.G. and Steinberg, G.R.
DOI: 10.1038/s42255-025-01264-3FASEB Journal
Townsend, L.K. and Wright, D. and Pyle, W.G.
DOI: 10.1096/fj.202502431RPhysiological reports
Okada, T.E. and Jeromson, S. and Rathwell, S. and Wright, D.C. and Bomhof, M.R.
DOI: 10.14814/phy2.70066Physiological Reports
Wright, D.C. and Cheng, A.J. and MacPherson, R.E.K.
DOI: 10.14814/phy2.15960Journal of Applied Physiology
Arbeau, M. and Baranowski, B.J. and Jeromson, S. and Bellucci, A. and Akcan, M. and Trang, S. and Eisner, K. and Medak, K.D. and Wright, D.C.
DOI: 10.1152/japplphysiol.00519.2024iScience
Medak, K.D. and Jeromson, S. and Bellucci, A. and Arbeau, M. and Wright, D.C.
DOI: 10.1016/j.isci.2023.108628Journal of Physiology
Jeromson, S. and Akcan, M. and Baranowski, B. and Arbeau, M. and Bellucci, A. and Wright, D.C.
DOI: 10.1113/JP287256Journal of Physiology
Wright, D.C.
DOI: 10.1113/JP284107Nature Metabolism
Townsend, L.K. and Wang, D. and Wright, D.C. and Blondin, D.P.
DOI: 10.1038/s42255-023-00837-4Nutrition Research
Medak, K.D. and McKie, G.L. and Peppler, W.T. and Shamshoum, H. and Dibe, H.A. and Mutch, D.M. and Josse, A.R. and Wright, D.C.
DOI: 10.1016/j.nutres.2023.09.003Nutrition Research
Gonzalez-Soto, M. and Woods, S.E. and MacLeod, B. and Wright, D.C. and Mutch, D.M.
DOI: 10.1016/j.nutres.2023.03.005Obesity
Seguin, I. and Medak, K.D. and Shamshoum, H. and Hahn, M.K. and Wright, D.C.
DOI: 10.1002/oby.23630Journal of Applied Physiology
Marko, D.M. and Finch, M.S. and Yang, A.J.T. and Castellani, L.N. and Peppler, W.T. and Wright, D.C. and MacPherson, R.E.K.
DOI: 10.1152/japplphysiol.00520.2022Physiological Reports
Adams, J.C. and Price, O.J. and Rogers, N. and Rounds, S. and Taruno, A. and Theiss, A.L. and Uchida, S. and Wright, D.C.
DOI: 10.14814/phy2.15874Frontiers in Pharmacology
Medak, K.D. and Weber, A.J. and Shamshoum, H. and McKie, G.L. and Hahn, M.K. and Wright, D.C.
DOI: 10.3389/fphar.2023.1127634Biomedicine and Pharmacotherapy
Shamshoum, H. and Medak, K.D. and McKie, G.L. and Jeromson, S. and Hahn, M.K. and Wright, D.C.
DOI: 10.1016/j.biopha.2023.115671Endocrinology (United States)
Pereira, S. and Au, E. and Agarwal, S.M. and Wright, D.C. and Hahn, M.K.
DOI: 10.1210/endocr/bqad025The Journal of Nutritional Biochemistry
Alex Rajna and Liam Hayden Brown and Sara Michaela Frangos and Melissa Gonzalez-Soto and Barbora Hucik and Chenxuan Wang and David Charles Wright and David Michael Mutch
DOI: 10.1016/j.jnutbio.2022.10894004 / 2022
Physiological Reports
Kyle D. Medak and Greg L. McKie and Hesham Shamshoum and Ian Seguin and David C. Wright
DOI: 10.14814/phy2.1518702 / 2022
Journal of Applied Physiology
Logan K. Townsend and Kyle Medak and Alyssa J. Weber and Hana Dibe and Hesham Shamshoum and David C. Wright
DOI: 10.1152/japplphysiol.00698.202102 / 2022
The Journal of Physiology
Greg L. McKie and Hesham Shamshoum and Kristin L. Hunt and Hayley H. A. Thorpe and Hana A. Dibe and Jibran Y. Khokhar and Christine A. Doucette and David C. Wright
DOI: 10.1113/JP28177402 / 2022
Biology Open
Hinks, A. and Jacob, K. and Mashouri, P. and Medak, K.D. and Franchi, M.V. and Wright, D.C. and Brown, S.H.M. and Power, G.A.
DOI: 10.1242/bio.059491Therapeutic Advances in Psychopharmacology
Singh, R. and Stogios, N. and Smith, E. and Lee, J. and Maksyutynsk, K. and Au, E. and Wright, D.C. and De Palma, G. and Graff-Guerrero, A. and Gerretsen, P. and Mller, D.J. and Remington, G. and Hahn, M. and Agarwal, S.M.
DOI: 10.1177/20451253221096525Journal of Physiology
Shamshoum, H. and Medak, K.D. and McKie, G.L. and Hahn, M.K. and Wright, D.C.
DOI: 10.1113/JP282922Journal of Physiology
Weber, A. and Medak, K.D. and Townsend, L.K. and Wright, D.C.
DOI: 10.1113/JP283469Frontiers in Endocrinology
Plomgaard, P. and Hansen, J.S. and Townsend, L.K. and Gudiksen, A. and Secher, N.H. and Clemmesen, J.O. and St?ving, R.K. and Goetze, J.P. and Wright, D.C. and Pilegaard, H.
DOI: 10.3389/fendo.2022.1037948bioRxiv
Hinks, A. and Jacob, K. and Mashouri, P. and Medak, K.D. and Franchi, M.V. and Wright, D.C. and Brown, S.H.M. and Power, G.A.
DOI: 10.1101/2022.02.18.481073Function
Politis-Barber, V. and Petrick, H.L. and Raajendiran, A. and Desormeaux, G.J. and Brunetta, H.S. and Dos Reis, L.M. and Mori, M.A. and Wright, D.C. and Watt, M.J. and Holloway, G.P.
DOI: 10.1093/function/zqac037FASEB Journal
McKie, G.L. and Medak, K.D. and Shamshoum, H. and Wright, D.C.
DOI: 10.1096/fj.202101905RRThe Journal of Clinical Endocrinology & Metabolism
Logan K Townsend and Rebecca E K MacPherson and David C Wright
DOI: 10.1210/clinem/dgab33307 / 2021
Behavioural Brain Research
Hesham Shamshoum and Kyle D. Medak and David C. Wright
DOI: 10.1016/j.bbr.2020.11304902 / 2021
Journal of Applied Physiology
Hesham Shamshoum and Greg L. McKie and Kyle D. Medak and Kristen E. Ashworth and Bruce E. Kemp and David C. Wright
DOI: 10.1152/japplphysiol.00876.202002 / 2021
Biology Letters
McKie, G.L. and Wright, D.C.
DOI: 10.1098/rsbl.2021.0171FASEB Journal
Townsend, L.K. and Weber, A.J. and Day, E.A. and Shamshoum, H. and Shaw, S.J. and Perry, C.G.R. and Kemp, B.E. and Steinberg, G.R. and Wright, D.C.
DOI: 10.1096/fj.202000954RBiochemical Journal
Greg L. McKie and David C. Wright
DOI: 10.1042/BCJ2019046603 / 2020
Physiological Reports
Hana A. Dibe and Logan K. Townsend and Greg L. McKie and David C. Wright
DOI: 10.14814/phy2.1437002 / 2020
Obesity
Logan K. Townsend and Shivam Gandhi and Hesham Shamshoum and Sarah K. Trottier and David M. Mutch and Raylene A. Reimer and Jane Shearer and Paul J. LeBlanc and David C. Wright
DOI: 10.1002/oby.2262101 / 2020
bioRxiv
Laskary, A. and Townsend, L.K. and Wright, D. and Pyle, W.G.
DOI: 10.1101/2020.03.03.975185International Journal of Exercise Science
Islam, H. and Smith, M.M.W. and Scribbans, T.D. and McCrady, E. and Castellani, L.N. and Allen, M.D. and Wright, D.C. and Simpson, C.A. and Gurd, B.J.
Current Opinion in Pharmacology
Peppler, W.T. and Townsend, L.K. and Wright, D.C.
DOI: 10.1016/j.coph.2020.04.010The Routledge Handbook on Biochemistry of Exercise
Townsend, L.K. and McKie, G.L. and Shamshoum, H. and Wright, D.C.
American journal of physiology. Cell physiology
Townsend, L.K. and Weber, A.J. and Barbeau, P.-A. and Holloway, G.P. and Wright, D.C.
DOI: 10.1152/ajpcell.00313.2019American Journal of Physiology - Endocrinology and Metabolism
Medak, K.D. and Shamshoum, H. and Peppler, W.T. and Wright, D.C.
DOI: 10.1152/AJPENDO.00309.2020The Journal of Physiology
Greg L. McKie and Kyle D. Medak and Carly M. Knuth and Hesham Shamshoum and Logan K. Townsend and Willem T. Peppler and David C. Wright
DOI: 10.1113/JP27822109 / 2019
Pflgers Archiv - European Journal of Physiology
Logan K. Townsend and David C. Wright
DOI: 10.1007/s00424-018-2177-103 / 2019
Journal of Biological Chemistry
Frendo-Cumbo, S. and Jaldin-Fincati, J.R. and Coyaud, E. and Laurent, E.M.N. and Townsend, L.K. and Tan, J.M.J. and Xavier, R.J. and Pillon, N.J. and Raught, B. and Wright, D.C. and Brumell, J.H. and Klip, A.
DOI: 10.1074/jbc.RA119.009110Medicine and Science in Sports and Exercise
Peppler, W.T. and Castellani, L.N. and Root-Mccaig, J. and Townsend, L.K. and Sutton, C.D. and Frendo-Cumbo, S. and Medak, K.D. and Macpherson, R.E.K. and Charron, M.J. and Wright, D.C.
DOI: 10.1249/MSS.0000000000001893FASEB Journal
Townsend, L.K. and Medak, K.D. and Knuth, C.M. and Peppler, W.T. and Charron, J. and Wright, D.C.
DOI: 10.1096/fj.201802048RRJournal of Lipid Research
Townsend, L.K. and Medak, K.D. and Peppler, W.T. and Meers, G.M. and Scott Rector, R. and LeBlanc, P.J. and Wright, D.C.
DOI: 10.1194/jlr.M092510FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shamshoum, H. and Medak, K.D. and Townsend, L.K. and Ashworth, K.E. and Bush, N.D. and Hahn, M.K. and Kemp, B.E. and Wright, D.C.
DOI: 10.1096/fj.201901820RPsychoneuroendocrinology
Medak, K.D. and Townsend, L.K. and Hahn, M.K. and Wright, D.C.
DOI: 10.1016/j.psyneuen.2019.104413Poultry Science
McKnight, L.L. and Peppler, W. and Wright, D.C. and Page, G. and Han, Y.
DOI: 10.3382/ps/pez241American Journal of Physiology - Gastrointestinal and Liver Physiology
Peppler, W.T. and Townsend, L.K. and Meers, G.M. and Panasevich, M.R. and Macpherson, R.E.K. and Rector, R.S. and Wright, D.C.
DOI: 10.1152/ajpgi.00097.2018Journal of Proteome Research
Mayengbam, S. and Mickiewicz, B. and Trottier, S.K. and Mu, C. and Wright, D.C. and Reimer, R.A. and Vogel, H.J. and Shearer, J.
DOI: 10.1021/acs.jproteome.9b00304The Journal of Physiology
Carly M. Knuth and Willem T. Peppler and Logan K. Townsend and Paula M. Miotto and Anders Gudiksen and David C. Wright
DOI: 10.1113/JP27622809 / 2018
Psychoneuroendocrinology
Townsend, L.K. and Peppler, W.T. and Bush, N.D. and Wright, D.C.
DOI: 10.1016/j.psyneuen.2017.12.004Journal of Animal Physiology and Animal Nutrition
McKnight, L.L. and France, J. and Wright, D. and Davenport, G. and Shoveller, A.K.
DOI: 10.1111/jpn.12713Scientific Reports
Castellani, L.N. and Peppler, W.T. and Miotto, P.M. and Bush, N. and Wright, D.C.
DOI: 10.1038/s41598-018-19260-xAmerican Journal of Physiology - Endocrinology and Metabolism
Peppler, W.T. and Townsend, L.K. and Knuth, C.M. and Foster, M.T. and Wright, D.C.
DOI: 10.1152/ajpendo.00226.2017Applied Physiology, Nutrition and Metabolism
Beaudoin, M.-S. and Gaudio, N. and Reed, J.K. and Foute-Nelong, J. and Mutch, D.M. and Wright, D.C.
DOI: 10.1139/apnm-2017-0606Journal of Pharmacology and Experimental Therapeutics
Bush, N.D. and Townsend, L.K. and Wright, D.C.
DOI: 10.1124/jpet.118.248393Science Translational Medicine
Foster, A.J. and Platt, M.J. and Huber, J.S. and Eadie, A.L. and Arkell, A.M. and Romanova, N. and Wright, D.C. and Gillis, T.E. and Murrant, C.L. and Brunt, K.R. and Simpson, J.A.
DOI: 10.1126/scitranslmed.aag1303Obesity
Trottier, S.K. and MacPherson, R.E.K. and Knuth, C.M. and Townsend, L.K. and Peppler, W.T. and Mikhaeil, J.S. and Leveille, C.F. and LeBlanc, P.J. and Shearer, J. and Reimer, R.A. and Wright, D.C.
DOI: 10.1002/oby.21941Adipocyte
Peppler, W.T. and Anderson, Z.G. and MacRae, L.M. and MacPherson, R.E.K. and Wright, D.C.
DOI: 10.1080/21623945.2016.1259778Adipocyte
MacDonald, T.L. and MacPherson, R. and Castellani, L. and Cervone, D. and Anderson, E. and Wright, D.C. and Dyck, D.J.
DOI: 10.1080/21623945.2017.1287638Psychoneuroendocrinology
Castellani, L.N. and Peppler, W.T. and Sutton, C.D. and Whitfield, J. and Charron, M.J. and Wright, D.C.
DOI: 10.1016/j.psyneuen.2017.05.005Physiological Reports
Townsend, L.K. and Knuth, C.M. and Wright, D.C.
DOI: 10.14814/phy2.13247American Journal of Physiology - Cell Physiology
Dragos, S.M. and Bergeron, K.F. and Desmarais, F. and Suitor, K. and Wright, D.C. and Mounier, C. and Mutch, D.M.
DOI: 10.1152/ajpcell.00097.2017Biochemical and Biophysical Research Communications
Peppler, W.T. and Miotto, P.M. and Holloway, G.P. and Wright, D.C.
DOI: 10.1016/j.bbrc.2017.03.067Physiological Genomics
Panasevich, M.R. and Peppler, W.T. and Oerther, D.B. and Wright, D.C. and Rector, R.S.
DOI: 10.1152/physiolgenomics.00012.2017Canadian Journal of Physiology and Pharmacology
Singh, R.K. and Lui, E. and Wright, D. and Taylor, A. and Bakovic, M.
DOI: 10.1139/cjpp-2016-0510PLoS ONE
Theriau, C.F. and Sauv{\'e}, O.S. and Beaudoin, M.-S. and Wright, D.C. and Connor, M.K.
DOI: 10.1371/journal.pone.0183897Physiological Reports
Frendo-Cumbo, S. and MacPherson, R.E.K. and Wright, D.C.
DOI: 10.14814/phy2.12877Frontiers in Endocrinology
Rebalka, I.A. and Raleigh, M.J. and Snook, L.A. and Rebalka, A.N. and MacPherson, R.E.K. and Wright, D.C. and Schertzer, J.D. and Hawke, T.J.
DOI: 10.3389/fendo.2016.00095Molecular nutrition & food research
Miotto, P.M. and Frendo-Cumbo, S. and Sacco, S.M. and Wright, D.C. and Ward, W.E. and Holloway, G.P.
DOI: 10.1002/mnfr.201500870Applied Physiology, Nutrition and Metabolism
Thyfault, J.P. and Wright, D.C.
DOI: 10.1139/apnm-2016-0122Obesity
MacPherson, R.E.K. and Gamu, D. and Frendo-Cumbo, S. and Castellani, L. and Kwon, F. and Tupling, A.R. and Wright, D.C.
DOI: 10.1002/oby.21521Journal of Ginseng Research
Garbett, J. and Wilson, S.A.F. and Ralston, J.C. and De Boer, A.A. and Lui, E.M.K. and Wright, D.C. and Mutch, D.M.
DOI: 10.1016/j.jgr.2015.07.001Muscle and Nerve
Dungan, C.M. and Li, Z. and Wright, D.C. and Williamson, D.L.
DOI: 10.1002/mus.24698Journal of Physiology
Perry, C.G.R. and Wright, D.C.
DOI: 10.1113/JP272573American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Peppler, W.T. and Anderson, Z.G. and Sutton, C.D. and Rector, R.S. and Wright, D.C.
DOI: 10.1152/ajpregu.00497.2015American Journal of Physiology - Cell Physiology
Macpherson, R.E.K. and Dragos, S.M. and Ramos, S. and Sutton, C. and Frendo-Cumbo, S. and Castellani, L. and Watt, M.J. and Perry, C.G.R. and Mutch, D.M. and Wright, D.C.
DOI: 10.1152/ajpcell.00126.2016FEBS Letters
Snook, L.A. and Wright, D.C. and Holloway, G.P.
DOI: 10.1002/1873-3468.12260American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Snook, L.A. and Macpherson, R.E.K. and Monaco, C.M.F. and Frendo-Cumbo, S. and Castellani, L. and Peppler, W.T. and Anderson, Z.G. and Buzelle, S.L. and Leblanc, P.J. and Holloway, G.P. and Wright, D.C.
DOI: 10.1152/ajpregu.00072.2016Journal of Applied Physiology
Rogers, R.S. and Beaudoin, M.-S. and Wheatley, J.L. and Wright, D.C. and Geiger, P.C.
DOI: 10.1152/japplphysiol.00286.2014Journal of Applied Physiology
MacPherson, R.E.K. and Baumeister, P. and Peppler, W.T. and Wright, D.C. and Little, J.P.
DOI: 10.1152/japplphysiol.00299.2015Medicine and Science in Sports and Exercise
Macpherson, R.E.K. and Huber, J.S. and Frendo-Cumbo, S. and Simpson, J.A. and Wright, D.C.
DOI: 10.1249/MSS.0000000000000660Lipids in Health and Disease
Hamilton, M. and Hopkins, L.E. and AlZahal, O. and MacDonald, T.L. and Cervone, D.T. and Wright, D.C. and McBride, B.W. and Dyck, D.J.
DOI: 10.1186/s12944-015-0122-2Journal of Applied Physiology
Castellani, L. and Perry, C.G.R. and MacPherson, R.E.K. and Root-McCaig, J. and Huber, J.S. and Arkell, A.M. and Simpson, J.A. and Wright, D.C.
DOI: 10.1152/japplphysiol.00551.2015PLoS ONE
McKnight, L.L. and Root-McCaig, J. and Wright, D. and Davenport, G.M. and France, J. and Shoveller, A.K.
DOI: 10.1371/journal.pone.0143324Diabetologia
Bonen, A. and Jain, S.S. and Snook, L.A. and Han, X.-X. and Yoshida, Y. and Buddo, K.H. and Lally, J.S. and Pask, E.D. and Paglialunga, S. and Beaudoin, M.-S. and Glatz, J.F.C. and Luiken, J.J.F.P. and Harasim, E. and Wright, D.C. and Chabowski, A. and Holloway, G.P.
DOI: 10.1007/s00125-015-3691-8American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Allwood, M.A. and Foster, A.J. and Arkell, A.M. and Beaudoin, M.-S. and Snook, L.A. and Romanova, N. and Murrant, C.L. and Holloway, G.P. and Wright, D.C. and Simpson, J.A.
DOI: 10.1152/ajpregu.00447.2014Obesity
MacPherson, R.E.K. and Wright, D.C.
DOI: 10.1002/oby.21234American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Snook, L.A. and Nelson, E.M. and Dyck, D.J. and Wright, D.C. and Holloway, G.P.
DOI: 10.1152/ajpregu.00003.2015Physiological Reports
Buzelle, S.L. and MacPherson, R.E.K. and Peppler, W.T. and Castellani, L. and Wright, D.C.
DOI: 10.14814/phy2.12312Biochemical and Biophysical Research Communications
Dungan, C.M. and Wright, D.C. and Williamson, D.L.
DOI: 10.1016/j.bbrc.2014.10.032Lipids in Health and Disease
Stefanson, A. and Hopkins, L.E. and Alzahal, O. and Ritchie, I.R. and Macdonald, T. and Wright, D.C. and McBride, B.W. and Dyck, D.J.
DOI: 10.1186/1476-511X-13-101American Journal of Physiology - Endocrinology and Metabolism
MacPherson, R.E.K. and Castellani, L. and Beaudoin, M.-S. and Wright, D.C.
DOI: 10.1152/ajpendo.00287.2014Physiological Reports
Ritchie, I.R.W. and Wright, D.C. and Dyck, D.J.
DOI: 10.14814/phy2.12146American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Podobed, P. and Glen Pyle, W. and Ackloo, S. and Alibhai, F.J. and Tsimakouridze, E.V. and Ratcliffe, W.F. and Mackay, A. and Simpson, J. and Wright, D.C. and Kirby, G.M. and Young, M.E. and Martino, T.A.
DOI: 10.1152/ajpregu.00011.2014Journal of Physiology
Beaudoin, M.-S. and Perry, C.G.R. and Arkell, A.M. and Chabowski, A. and Simpson, J.A. and Wright, D.C. and Holloway, G.P.
DOI: 10.1113/jphysiol.2013.270538Applied Physiology, Nutrition and Metabolism
Wright, D.C.
DOI: 10.1139/apnm-2013-0316Journal of Applied Physiology
Castellani, L. and Root-Mccaig, J. and Frendo-Cumbo, S. and Beaudoin, M.-S. and Wright, D.C.
DOI: 10.1152/japplphysiol.00074.2014Journal of Physiology
Ritchie, I.R.W. and Macdonald, T.L. and Wright, D.C. and Dyck, D.J.
DOI: 10.1113/jphysiol.2014.273680Obesity
Beaudoin, M.-S. and Snook, L.A. and Arkell, A.M. and Stefanson, A. and Wan, Z. and Simpson, J.A. and Holloway, G.P. and Wright, D.C.
DOI: 10.1002/oby.20717Obesity
Wan, Z. and Root-Mccaig, J. and Castellani, L. and Kemp, B.E. and Steinberg, G.R. and Wright, D.C.
DOI: 10.1002/oby.20605Circulation Research
Alibhai, F.J. and Tsimakouridze, E.V. and Chinnappareddy, N. and Wright, D.C. and Billia, F. and O{'}Sullivan, M.L. and Pyle, W.G. and Sole, M.J. and Martino, T.A.
DOI: 10.1161/CIRCRESAHA.114.302995Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Mennes, E. and Dungan, C.M. and Frendo-Cumbo, S. and Williamson, D.L. and Wright, D.C.
DOI: 10.1093/gerona/glt156PLoS ONE
Wan, Z. and Ritchie, I. and Beaudoin, M.-S. and Castellani, L. and Chan, C.B. and Wright, D.C.
DOI: 10.1371/annotation/3029d433-8e4e-41ca-a2da-6561aa0701bdApplied Physiology, Nutrition and Metabolism
Williams, C.B. and Zelt, J.G.E. and Castellani, L.N. and Little, J.P. and Jung, M.E. and Wright, D.C. and Tschakovsky, M.E. and Gurd, B.J.
DOI: 10.1139/apnm-2013-0101American Journal of Physiology - Cell Physiology
Wan, Z. and Matravadia, S. and Holloway, G.P. and Wright, D.C.
DOI: 10.1152/ajpcell.00372.2012Journal of Applied Physiology
MacDonald, T.L. and Wan, Z. and Frendo-Cumbo, S. and Dyck, D.J. and Wright, D.C.
DOI: 10.1152/japplphysiol.00558.2013Journal of Physiology
Smith, B.K. and Perry, C.G.R. and Herbst, E.A.F. and Ritchie, I.R. and Beaudoin, M.-S. and Smith, J.C. and Neufer, P.D. and Wright, D.C. and Holloway, G.P.
DOI: 10.1113/jphysiol.2013.259226American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Beaudoin, M.-S. and Snook, L.A. and Arkell, A.M. and Simpson, J.A. and Holloway, G.P. and Wright, D.C.
DOI: 10.1152/ajpregu.00200.2013Journal of Applied Physiology
O{'}Neill, H.M. and Palanivel, R. and Wright, D.C. and Macdonald, T. and Lally, J.S. and Schertzer, J.D. and Steinberg, G.R.
DOI: 10.1152/japplphysiol.00946.2012Mitochondrion
Harasym, A.C. and Thrush, A.B. and Harper, M.-E. and Wright, D.C. and Chan, C.B.
DOI: 10.1016/j.mito.2013.04.006American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Williams, D.B. and Wan, Z. and Frier, B.C. and Bell, R.C. and Field, C.J. and Wright, D.C.
DOI: 10.1152/ajpregu.00304.2011American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Gulli, R.A. and Tishinsky, J.M. and MacDonald, T. and Robinson, L.E. and Wright, D.C. and Dyck, D.J.
DOI: 10.1152/ajpregu.00176.2012PLoS ONE
Wan, Z. and Perry, C.G.R. and Macdonald, T. and Chan, C.B. and Holloway, G.P. and Wright, D.C.
DOI: 10.1371/journal.pone.0051233PLoS ONE
Wan, Z. and Ritchie, I. and Beaudoin, M.-S. and Castellani, L. and Chan, C.B. and Wright, D.C.
DOI: 10.1371/journal.pone.0041719Encyclopedia of Exercise Medicine in Health and Disease
Dyck, D.J. and Robinson, L.E. and Wright, D.C.
DOI: 10.1007/978-3-540-29807-6_297Journal of Physiology
Perry, C.G.R. and Kane, D.A. and Herbst, E.A.F. and Mukai, K. and Lark, D.S. and Wright, D.C. and Heigenhauser, G.J.F. and Neufer, P.D. and Spriet, L.L. and Holloway, G.P.
DOI: 10.1113/jphysiol.2012.234682Biochemical Journal
Smith, B.K. and Perry, C.G.R. and Koves, T.R. and Wright, D.C. and Smith, J.C. and Neufer, P.D. and Muoio, D.M. and Holloway, G.P.
DOI: 10.1042/BJ20121110American Journal of Physiology - Cell Physiology
Frier, B.C. and Wan, Z. and Williams, D.B. and Stefanson, A.L. and Wright, D.C.
DOI: 10.1152/ajpcell.00410.2011Obesity
Wan, Z. and Frier, B.C. and Williams, D.B. and Wright, D.C.
DOI: 10.1038/oby.2011.252American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Frier, B.C. and Jacobs, R.L. and Wright, D.C.
DOI: 10.1152/ajpregu.00367.2010Applied Physiology, Nutrition and Metabolism
Little, J.P. and Safdar, A. and Benton, C.R. and Wright, D.C.
DOI: 10.1139/h11-076Journal of Applied Physiology
Frier, B.C. and Hancock, C.R. and Little, J.P. and Fillmore, N. and Bliss, T.A. and Thomson, D.M. and Wan, Z. and Wright, D.C.
DOI: 10.1152/japplphysiol.00279.2011Metabolism: Clinical and Experimental
Peckett, A.J. and Wright, D.C. and Riddell, M.C.
DOI: 10.1016/j.metabol.2011.06.012American Journal of Physiology - Cell Physiology
Wan, Z. and Thrush, A.B. and Legare, M. and Frier, B.C. and Sutherland, L.N. and Williams, D.B. and Wright, D.C.
DOI: 10.1152/ajpcell.00188.2010Nutrition and Metabolism
Jacome-Sosa, M.M. and Lu, J. and Wang, Y. and Ruth, M.R. and Wright, D.C. and Reaney, M.J. and Shen, J. and Field, C.J. and Vine, D.F. and Proctor, S.D.
DOI: 10.1186/1743-7075-7-60American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Mullen, K.L. and Pritchard, J. and Ritchie, I. and Snook, L.A. and Chabowski, A. and Bonen, A. and Wright, D. and Dyck, D.J.
DOI: 10.1152/ajpregu.90774.2008American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Frier, B.C. and Williams, D.B. and Wright, D.C.
DOI: 10.1152/ajpregu.00422.2009American Journal of Physiology - Endocrinology and Metabolism
Williams, D.B. and Sutherland, L.N. and Bomhof, M.R. and Basaraba, S.A.U. and Thrush, A.B. and Dyck, D.J. and Field, C.J. and Wright, D.C.
DOI: 10.1152/ajpendo.90913.2008Journal of Nutrition
Wang, Y. and Jacome-Sosa, M.M. and Ruth, M.R. and Goruk, S.D. and Reaney, M.J. and Glimm, D.R. and Wright, D.C. and Vine, D.F. and Field, C.J. and Proctor, S.D.
DOI: 10.3945/jn.109.109488Journal of Physiology
Sutherland, L.N. and Bomhof, M.R. and Capozzi, L.C. and Basaraba, S.A.U. and Wright, D.C.
DOI: 10.1113/jphysiol.2008.165464Proceedings of the National Academy of Sciences of the United States of America
Hancock, C.R. and Han, D.-H. and Chen, M. and Terada, S. and Yasuda, T. and Wright, D.C. and Holloszy, J.O.
DOI: 10.1073/pnas.0802057105Applied Physiology, Nutrition and Metabolism
Wright, D. and Sutherland, L.
DOI: 10.1139/H07-155American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Thrush, A.B. and Heigenhauser, G.J. and Mullen, K.L. and Wright, D.C. and Dyck, D.J.
DOI: 10.1152/ajpregu.00909.2007American Journal of Physiology - Endocrinology and Metabolism
Sutherland, L.N. and Capozzi, L.C. and Turchinsky, N.J. and Bell, R.C. and Wright, D.C.
DOI: 10.1152/ajpendo.90408.2008Applied Physiology, Nutrition and Metabolism
Benton, C.R. and Wright, D.C. and Bonen, A.
DOI: 10.1139/H08-074Journal of Biological Chemistry
Wright, D.C. and Geiger, P.C. and Han, D.-H. and Jones, T.E. and Holloszy, J.O.
DOI: 10.1074/jbc.M611252200Applied Physiology, Nutrition and Metabolism
Wright, D.C.
DOI: 10.1139/H07-062American Journal of Physiology - Endocrinology and Metabolism
Geiger, P.C. and Hancock, C. and Wright, D.C. and Han, D.-H. and Holloszy, J.O.
DOI: 10.1152/ajpendo.00701.2006Journal of Biological Chemistry
Wright, D.C. and Han, D.-H. and Garcia-Roves, P.M. and Geiger, P.C. and Jones, T.E. and Holloszy, J.O.
DOI: 10.1074/jbc.M606116200American Journal of Physiology - Endocrinology and Metabolism
Geiger, P.C. and Dong, H.H. and Wright, D.C. and Holloszy, J.O.
DOI: 10.1152/ajpendo.00273.2006American Journal of Physiology - Endocrinology and Metabolism
Wright, D.C. and Geiger, P.C. and Han, D.-H. and Holloszy, J.O.
DOI: 10.1152/ajpendo.00280.2005American Journal of Physiology - Endocrinology and Metabolism
Magkos, F. and Wright, D.C. and Patterson, B.W. and Mohammed, B.S. and Mittendorfer, B.
DOI: 10.1152/ajpendo.00259.2005American Journal of Physiology Endocrinology and Metabolism
Wright, D.C. and Geiger, P.C. and Holloszy, J.O. and Han, D.-H.
DOI: 10.1152/ajpendo.00561.2004American Journal of Physiology - Endocrinology and Metabolism
Geiger, P.C. and Wright, D.C. and Han, D.-H. and Holloszy, J.O.
DOI: 10.1152/ajpendo.00477.2004American Journal of Physiology - Endocrinology and Metabolism
Wright, D.C. and Geiger, P.C. and Rheinheimer, M.J. and Han, D.H. and Holloszy, J.O.
DOI: 10.1152/ajpendo.00082.2004Diabetes
Wright, D.C. and Hucker, K.A. and Holloszy, J.O. and Han, D.H.
DOI: 10.2337/diabetes.53.2.330Life Sciences
Wright, D.C. and Fick, C.A. and Olesen, J.B. and Lim, K. and Barnes, B.R. and Craig, B.W.
DOI: 10.1016/j.lfs.2003.06.041Life Sciences
Wright, D.C. and Fick, C.A. and Olesen, J.B. and Craig, B.W.
DOI: 10.1016/S0024-3205(03)00256-XMetabolism: Clinical and Experimental
Wright, D.C. and Craig, B.W. and Fick, C.A. and Lim, K.I.
DOI: 10.1053/meta.2002.30500Exercise has profound effects on virtually every organ and tissue and profoundly influences how the body utilizes carbohydrate and fats. The wide-ranging effects of exercise are mediated, at least in part, by signaling factors secreted from different tissues, such as muscle, liver and fat tissue. A recently identified signaling factor that increases with exercise is GDF15. This molecule signals to the brain and regulates food intake. In addition, we have found that GDF15 also increases the utilization of fat in the liver and the production of molecules called ketone bodies that can be taken up and used as a fuel source by other tissues like the heart and muscle. The purpose of the current project is to determine how GDF15 increases the production of ketone bodies, and then investigate if GDF15 regulates the effects of exercise on these processes. It is our hope that identifying how GDF15 controls sugar and fat metabolism and the role that it plays in exercise, will lend insight into potential new avenues to treat conditions of altered sugar metabolism such as those seen in type 2 diabetes.
Antipsychotic drugs are used to treat a number of conditions including schizophrenia, anxiety and bipolar disorders and their use has increased dramatically over the past decade. Unfortunately, these drugs have harmful metabolic side effects such as weight gain and rapid increases in blood sugar with each dose of drug. Together these effects increase the risk for developing type 2 diabetes and cardiovascular disease. In recent work, we have shown that a single session of exercise prior to treatment with antipsychotics completely protected against the acute increase in blood sugar. Although exercise adherence is poor in individuals taking anti-psychotic drugs we have been using exercise as a model to identify pathways which could be targeted to reduce the metabolic side effects of these drugs. Based on preliminary data from our laboratory we have shown that the activation of an energy-sensing enzyme called AMPK confers the same protection against anti-psychotic metabolic side effects as exercise. The purpose of this project is to examine the effects of AMPK in protecting against the acute and long-term metabolic side effects of anti-psychotic drugs and to determine if AMPK mediates the beneficial effects of exercise. The data generated from these studies will provide insight into new approaches that could be used to lessen the metabolic consequences of anti-psychotic drugs and could shed insight into the mechanisms mediating the protective effects of exercise.
The long-term objective of my NSERC program is to examine how environmental, nutritional and exercise stressors modulate adipose tissue and liver metabolism, the underlying mechanisms therein, and how this influences systemic carbohydrate and fat homeostasis. To address these basic, fundamental questions, we use rodent models coupled with cell/tissue culture approaches and examine endpoints ranging from whole body energy expenditure to the regulation of gene expression. A new direction we have started to explore is the impact of cold stress on adipose tissue and systemic metabolism. Building upon recent discoveries, and further guided by exciting
preliminary data, over the next 5 years we will examine how the sensation of cold triggers metabolic adaptations, specifically examining the role of the cold sensing cation channel TRPM8 (Transient Receptor Potential cation channel subfamily Melastatin member 8) in these processes. In the first two aims we will decipher the mechanisms through which activation of TRPM8 acutely increases thermogenesis (Aim 1) and how the repeated activation of TRPM8 induces the expression of mitochondrial/thermogenic genes and proteins (Aim 2). In Aim 3 we will investigate the necessity of TRPM8 in mediating the metabolic response to cold and in Aim 4 will explore interactions between TRPM8 activation and exercise in the regulation of adipose tissue and systemic metabolism. The experiments outlined in this proposal will increase our basic, fundamental understanding of adipose tissue biology and how these changes impact systemic fuel metabolism. A diverse group of HQP will receive a rich training experience which will prepare them for careers, or further training, in the natural sciences.
CIHR Project Grant (2021-26): Identifying a Novel Role for GDF15 during Exercise
CIHR Project Grant (2018-24): Targeting Exercise Activated Pathways to Offset the Metabolic Side Effects of Anti-Psychotic Drugs
NSERC Discovery Grant (2017-22): Role of Adipose Tissue and IL-6 in Liver Metabolism
Tier II Canada Research Chair in Lipids, Metabolism and Health (2010-2020)
Young Investigator Award Canadian Society of Exercise Physiology (2012)
CIHR New Investigator Award (2008-10)
Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.
Congratulations to BC Children’s Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institute of Health Research (CIHR) Fall 2023 Project Grant competition. Our research community received around $11 million in new research grants as principal investigators or co-investigators.
For people suffering from severe mental disorders such as schizophrenia, antipsychotic drugs can help reduce a number of psychotic symptoms, such as paranoia, delusions and hallucinations. Increasingly, these medications are being used off-label to treat bipolar disorder, anxiety or severe irritability, even amongst children and adolescents. Unfortunately, these drugs can have harmful metabolic side effects…
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