Overview

Steroid hormones control a wide range of normal biological processes but are also implicated in several disease processes including reproductive disorders, inflammation, diabetes, cardiovascular disease, and hormone-dependent cancers of male and female reproductive tissues. Synthetic steroids that act as agonists or antagonists are used widely as pharmacologic agents. The way steroids gain access to their target tissues is poorly understood. However, access is influenced primarily by two high affinity steroid-binding proteins in the blood: corticosteroid binding globulin (CBG) and sex hormone-binding globulin (SHBG). These two plasma proteins bind the glucocorticoids and sex steroids, respectively. By applying a combination of molecular biological, biochemical and physiological approaches we have gained new information about how CBG and SHBG are produced and function with respect to normal development and aging, and how they are involved in disease processes.

Publications

Author Correction: Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox
Scientific Reports
Cristina Saez-Lopez, Laura Brianso-Llort, J. Torres-Torronteras, Rafael Simó, Geoffrey L. Hammond, David M. Selva
DOI: 10.1038/s41598-018-23159-y
03/2018

Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam
Behavioural Brain Research
Mary Gemmel, Danny Harmeyer, Eszter Bögi, Marianne Fillet, Lesley A. Hill, Geoffrey L. Hammond, Thierry D. Charlier, Jodi L. Pawluski
DOI: 10.1016/j.bbr.2017.11.038
02/2018

Roles of Plasma Binding Proteins in Modulation of Hormone Action and Metabolism
Reference Module in Biomedical Sciences
Geoffrey L. Hammond, Lesley A. Hill, Phillip W. Round
DOI: 10.1016/b978-0-12-801238-3.64186-7
2018

Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice
Endocrine Connections
Yael Sofer, Nava Nevo, Michal Vechoropoulos, Gabi Shefer, Etty Osher, Nathan Landis, Karen Tordjman, Geoffrey L Hammond, Naftali Stern
DOI: 10.1530/ec-17-0240
11/2017

Neutrophil elastase-mediated regulation of adipose glucocorticoid exposure through CBG cleavage
Endocrine Abstracts
Mark Nixon, Lesley Hill, Caroline Underhill, Geoffrey Hammond, Brian Walker
DOI: 10.1530/endoabs.50.oc3.4
10/2017

Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress
Psychoneuroendocrinology
Mary Gemmel, Mariah Hazlett, Eszter Bögi, Sonsoles De Lacalle, Lesley A. Hill, Nikolaos Kokras, Geoffrey L. Hammond, Christina Dalla, Thierry D. Charlier, Jodi L. Pawluski
DOI: 10.1016/j.psyneuen.2017.07.480
10/2017

Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox
Scientific Reports
Cristina Saez-Lopez, Laura Brianso-Llort, J. Torres-Torronteras, Rafael Simó, Geoffrey L. Hammond, David M. Selva
DOI: 10.1038/s41598-017-12509-x
09/2017

Costs and Benefits of Extended Endocrine Strategies for Premenopausal Breast Cancer
Journal of the National Comprehensive Cancer Network
Janice S. Kwon, Gary Pansegrau, Melica Nourmoussavi, Geoffrey L. Hammond, Mark S. Carey
DOI: 10.6004/jnccn.2017.0136
08/2017

Sex hormone binding globulin: Expression throughout early development and adult pejerrey fish, Odontesthes bonariensis
General and Comparative Endocrinology
Anelisa González, Juan I. Fernandino, Geoffrey L. Hammond, Gustavo M. Somoza
DOI: 10.1016/j.ygcen.2017.02.004
06/2017

Resveratrol increases hepatic SHBG expression through human constitutive androstane receptor: a new Contribution to the French Paradox
Endocrine Abstracts
Cristina Saez-Lopez, Laura Brianso-Llort, Javier Torres-Torrenteras, Rafael Simo, Geoffrey Hammond, David Selva
DOI: 10.1530/endoabs.49.ep753
05/2017

Long-Term Consequences of Extended Endocrine Strategies for Premenopausal Breast Cancer [11OP]
Obstetrics & Gynecology
Janice S. Kwon, Gary Pansegrau, Melica Nourmoussavi, Geoffrey Hammond, Mark Carey
DOI: 10.1097/01.aog.0000513940.92490.68
05/2017

Ovarian ablation for premenopausal breast cancer: A review of treatment considerations and the impact of premature menopause
Cancer Treatment Reviews
Melica Nourmoussavi, Gary Pansegrau, Jason Popesku, Geoffrey L. Hammond, Janice S. Kwon, Mark S. Carey
DOI: 10.1016/j.ctrv.2017.02.005
04/2017

Sex Hormone-Binding Globulin and the Metabolic Syndrome
Male Hypogonadism
Geoffrey L. Hammond
DOI: 10.1007/978-3-319-53298-1_15
2017

Functional implications of corticosteroid-binding globulin N -glycosylation
Journal of Molecular Endocrinology
Marc Simard, Caroline Underhill, Geoffrey L Hammond
DOI: 10.1530/jme-17-0234
2017

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis
Scientific Reports
Michaël R. Laurent, Geoffrey L. Hammond, Marco Blokland, Ferran Jardí, Leen Antonio, Vanessa Dubois, Rougin Khalil, Saskia S. Sterk, Evelien Gielen, Brigitte Decallonne, Geert Carmeliet, Jean-Marc Kaufman, Tom Fiers, Ilpo T. Huhtaniemi, Dirk Vanderschueren, Frank Claessens
DOI: 10.1038/srep35539
10/2016

Control of androgen bioactivity by sex hormone-binding globulin
Endocrine Abstracts
Michael R Laurent, Leen Antonio, Marco H Blokland, Saskia S Sterk, Ferran Jardi, V Dubois, Jean-Mark Kaufman, Tom Fiers, Ilpo T Huhtaniemi, Geoffrey T. Hammond, Dirk Vanderschueren, Frank Claessens
DOI: 10.1530/endoabs.42.oc2
09/2016

Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats
Journal of Endocrinology
Lesley A Hill, Tamara S Bodnar, Joanne Weinberg, Geoffrey L Hammond
DOI: 10.1530/joe-16-0047
07/2016

Long-term consequences of ovarian ablation for premenopausal breast cancer
Breast Cancer Research and Treatment
Janice S. Kwon, Gary Pansegrau, Melica Nourmoussavi, Geoffrey Hammond, Mark S. Carey
DOI: 10.1007/s10549-016-3842-8
05/2016

Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action
Journal of Endocrinology
Geoffrey L Hammond
DOI: 10.1530/joe-16-0070
04/2016

Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein
Journal of Biological Chemistry
Ganna Vashchenko, Samir Das, Kyung-Mee Moon, Jason C. Rogalski, Matthew D. Taves, Kiran K. Soma, Filip Van Petegem, Leonard J. Foster, Geoffrey L. Hammond
DOI: 10.1074/jbc.m116.714378
03/2016

Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro
Molecular and Cellular Endocrinology
Michaël R. Laurent, Christine Helsen, Leen Antonio, Dieter Schollaert, Steven Joniau, Michel J. Vos, Brigitte Decallonne, Geoffrey L. Hammond, Dirk Vanderschueren, Frank Claessens
DOI: 10.1016/j.mce.2016.08.041
2016

Plasma corticosteroid-binding globulin: biomarker of inflammation onset and severity in a rat arthritis model
Endocrine Abstracts
Lesley Hill, Tamara Bodner, Joanne Weinberg, Geoffrey Hammond
DOI: 10.1530/endoabs.38.p387
10/2015

Society for Endocrinology International Medal Lecture
Endocrine Abstracts
Geoffrey Hammond
DOI: 10.1530/endoabs.38.pl9biog
10/2015

Controlling the freedom of steroids in health and disease
Endocrine Abstracts
Geoffrey Hammond
DOI: 10.1530/endoabs.38.pl9
10/2015

Impact of Corticosteroid-Binding Globulin Deficiency on Pregnancy and Neonatal Sex
The Journal of Clinical Endocrinology & Metabolism
Jing-Hui Lei, Xiaokui Yang, Sha Peng, Ying Li, Caroline Underhill, Cheng Zhu, Hai-Yan Lin, Hongmei Wang, Geoffrey L. Hammond
DOI: 10.1210/jc.2014-4254
05/2015

Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production, and Corticosterone Levels in Mice
Endocrinology
Jessica M. Adams, Veronica Otero-Corchon, Geoffrey L. Hammond, Johannes D. Veldhuis, Nathan Qi, Malcolm J. Low
DOI: 10.1210/en.2014-1429
03/2015

Naturally Occurring Mutations of Human Corticosteroid-Binding Globulin
The Journal of Clinical Endocrinology & Metabolism
Marc Simard, Lesley A. Hill, John G. Lewis, Geoffrey L. Hammond
DOI: 10.1210/jc.2014-3130
01/2015

Colony-Specific Differences in Endocrine and Immune Responses to an Inflammatory Challenge in Female Sprague Dawley Rats
Endocrinology
Tamara S. Bodnar, Lesley A. Hill, Matthew D. Taves, Wayne Yu, Kiran K. Soma, Geoffrey L. Hammond, Joanne Weinberg
DOI: 10.1210/en.2015-1497
2015

Pseudomonas Aeruginosa Elastase Disrupts the Cortisol-Binding Activity of Corticosteroid-Binding Globulin
Endocrinology
Marc Simard, Lesley A. Hill, Caroline M. Underhill, Bernd O. Keller, Ivan Villanueva, Robert E. W. Hancock, Geoffrey L. Hammond
DOI: 10.1210/en.2014-1055
08/2014

Naturally Occurring Mutants Inform SHBG Structure and Function
Molecular Endocrinology
Tsung-Sheng Wu, Geoffrey L. Hammond
DOI: 10.1210/me.2014-1058
07/2014

Development of the external genitalia: Perspectives from the spotted hyena (Crocuta crocuta)
Differentiation
Gerald R. Cunha, Gail Risbridger, Hong Wang, Ned J. Place, Mel Grumbach, Tristan J. Cunha, Mary Weldele, Al J. Conley, Dale Barcellos, Sanjana Agarwal, Argun Bhargava, Christine Drea, Geoffrey L. Hammond, Penti Siiteri, Elizabeth M. Coscia, Michael J. McPhaul, Laurence S. Baskin, Stephen E. Glickman
DOI: 10.1016/j.diff.2013.12.003
01/2014

Two Different Corticosteroid-Binding Globulin Variants that Lack Cortisol-Binding Activity in a Greek Woman
The Journal of Clinical Endocrinology & Metabolism
L. A. Hill, D. A. Vassiliadi, M. Simard, A. Pavlaki, I. Perogamvros, D. Hadjidakis, G. L. Hammond
DOI: 10.1210/jc.2012-2467
11/2012

Selective Cleavage of Human Sex Hormone-Binding Globulin by Kallikrein-Related Peptidases and Effects on Androgen Action in LNCaP Prostate Cancer Cells
Endocrinology
Washington Y. Sanchez, Simon J. de Veer, Joakim E. Swedberg, Eui-Ju Hong, Janet C. Reid, Terry P. Walsh, John D. Hooper, Geoffrey L. Hammond, Judith A. Clements, Jonathan M. Harris
DOI: 10.1210/en.2012-1011
07/2012

Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function
Psychoneuroendocrinology
Jodi L. Pawluski, Ursula M. Brain, Caroline M. Underhill, Geoffrey L. Hammond, Tim F. Oberlander
DOI: 10.1016/j.psyneuen.2011.11.011
07/2012

Evolving utility of sex hormone-binding globulin measurements in clinical medicine
Current Opinion in Endocrinology & Diabetes and Obesity
Geoffrey L. Hammond, Tsung-Sheng Wu, Marc Simard
DOI: 10.1097/med.0b013e328353732f
06/2012

Serum free estradiol and estrogen receptor-a mediated activity are related to decreased incident hip fractures in older women
Bone
Vanessa W. Lim, Jun Li, Yinhan Gong, Jian-Min Yuan, Tsung Sheng Wu, Geoffrey L. Hammond, Aizhen Jin, Woon-Puay Koh, E.L. Yong
DOI: 10.1016/j.bone.2012.03.006
06/2012

Rhox5 Rules in an Evolving Saga of Reproductive Diversity
Biology of Reproduction
Geoffrey L Hammond
DOI: 10.1095/biolreprod.112.101402
06/2012

High Frequency of SERPINA6 Polymorphisms that Reduce Plasma Corticosteroid-Binding Globulin Activity in Chinese Subjects
The Journal of Clinical Endocrinology & Metabolism
Hai-Yan Lin and Caroline Underhill and Jing-Hui Lei and Anna Helander-Claesson and Hwa-Yong Lee and Bernd R. Gardill and Yves A. Muller and Hongmei Wang and Geoffrey L. Hammond
DOI: 10.1210/jc.2011-3141
04/2012

Phylogenetic Comparisons Implicate Sex Hormone-Binding Globulin in “Masculinization” of the Female Spotted Hyena (Crocuta crocuta)
Endocrinology
Geoffrey L. Hammond, Solange Miguel-Queralt, Tamer M. Yalcinkaya, Caroline Underhill, Ned J. Place, Stephen E. Glickman, Christine M. Drea, Aaron P. Wagner, Pentti K. Siiteri
DOI: 10.1210/en.2011-1837
03/2012

Corticosteroid-Binding Globulin: Structure-Function Implications from Species Differences
PLoS ONE
Bernd R. Gardill, Michael R. Vogl, Hai-Yan Lin, Geoffrey L. Hammond, Yves A. Muller
DOI: 10.1371/journal.pone.0052759
2012

FoxA2 Mediates Monosaccharide-Induced Repression of SHBG Gene Expression by Regulating Lipid Homeostasis in HepG2 Cells.
Biology of Reproduction
Tsung-Sheng Wu, Geoffrey L. Hammond
DOI: 10.1093/biolreprod/85.s1.622
07/2011

Fathead Minnow Sex Hormone-binding Globulin as Tool for Ecotoxicology Assessment.
Biology of Reproduction
Jason T. Popesku, Vicki L. Marlatt, Geoffrey L. Hammond
DOI: 10.1093/biolreprod/85.s1.289
07/2011

When an Egg Is Not an Egg: Compromised Maternal mRNA Storage and Stabilization
Biology of Reproduction
M. Conti
DOI: 10.1095/biolreprod.111.094102
06/2011

Diverse Roles for Sex Hormone-Binding Globulin in Reproduction
Biology of Reproduction
G. L. Hammond
DOI: 10.1095/biolreprod.111.092593
05/2011

(Arene)Cl2Ru(II) complexes with N-coordinated estrogen and androgen isonicotinates: Interaction with sex hormone binding globulin and anticancer activity
Steroids
Rainer Schobert, Sebastian Seibt, Katharina Effenberger-Neidnicht, Caroline Underhill, Bernhard Biersack, Geoffrey L. Hammond
DOI: 10.1016/j.steroids.2010.12.009
03/2011

Gonadotropin-Releasing Hormone-II Increases Membrane Type I Metalloproteinase Production via ß-Catenin Signaling in Ovarian Cancer Cells
Endocrinology
Song Ling Poon, Man-Tat Lau, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/en.2010-0942
03/2011

37-kDa Laminin Receptor Precursor Mediates GnRH-II–Induced MMP-2 Expression and Invasiveness in Ovarian Cancer Cells
Molecular Endocrinology
Song Ling Poon, Christian Klausen, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/me.2010-0334
02/2011

37-kDa Laminin Receptor Precursor Mediates GnRH-II–Induced MMP-2 Expression and Invasiveness in Ovarian Cancer Cells
The Journal of Clinical Endocrinology & Metabolism
Song Ling Poon, Christian Klausen, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/jcem.96.2.zeg557b
02/2011

Cytoplasmic Accumulation of Incompletely Glycosylated SHBG Enhances Androgen Action in Proximal Tubule Epithelial Cells
Molecular Endocrinology
Eui-Ju Hong, Biswajyoti Sahu, Olli A. Jänne, Geoffrey L. Hammond
DOI: 10.1210/me.2010-0483
02/2011

Novel Corticosteroid-Binding Globulin Variant That Lacks Steroid Binding Activity
The Journal of Clinical Endocrinology & Metabolism
I. Perogamvros, C. Underhill, D. E. Henley, K. D. Hadfield, W. G. Newman, D. W. Ray, S. L. Lightman, G. L. Hammond, P. J. Trainer
DOI: 10.1210/jc.2010-0746
10/2010

Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin
Molecular and Cellular Endocrinology
Hai-Yan Lin, Yves A. Muller, Geoffrey L. Hammond
DOI: 10.1016/j.mce.2009.06.015
03/2010

Gonadotropin-Releasing Hormone-I-Mediated Activation of Progesterone Receptor Contributes to Gonadotropin a-Subunit Expression in Mouse Gonadotrophs
Endocrinology
Junling Chen, Beum-Soo An, Wai-Kin So, Linan Cheng, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/en.2009-0816
03/2010

Foreward
Molecular and Cellular Endocrinology
Geoffrey L. Hammond
DOI: 10.1016/j.mce.2009.09.015
03/2010

Structural analyses of sex hormone-binding globulin reveal novel ligands and function
Molecular and Cellular Endocrinology
George V. Avvakumov, Artem Cherkasov, Yves A. Muller, Geoffrey L. Hammond
DOI: 10.1016/j.mce.2009.09.005
03/2010

Gonadotropin-Releasing Hormone-Mediated Phosphorylation of Estrogen Receptor-a Contributes to fosB Expression in Mouse Gonadotrophs
Endocrinology
Junling Chen and Beum-Soo An and Linan Cheng and Geoffrey L. Hammond and Peter C. K. Leung
DOI: 10.1210/en.2009-0455
10/2009

Effects of aggressive encounters on plasma corticosteroid-binding globulin and its ligands in white-crowned sparrows
Hormones and Behavior
Thierry D. Charlier, Caroline Underhill, Geoffrey L. Hammond, Kiran K. Soma
DOI: 10.1016/j.yhbeh.2009.06.012
09/2009

Rapid Effect of GNRH1 on Follicle-Stimulating Hormone Beta Gene Expression in LbetaT2 Mouse Pituitary Cells Requires the Progesterone Receptor1
Biology of Reproduction
Beum-Soo An, Song Ling Poon, Wai-Kin So, Geoffrey L. Hammond, Peter C.K. Leung
DOI: 10.1095/biolreprod.109.076216
08/2009

Peroxisome-Proliferator Receptor ¿ Represses Hepatic Sex Hormone-Binding Globulin Expression
Endocrinology
David M. Selva, Geoffrey L. Hammond
DOI: 10.1210/en.2008-1289
05/2009

Reproductive experience alters corticosterone and CBG levels in the rat dam
Physiology & Behavior
Jodi L. Pawluski, Thierry D. Charlier, Stephanie E. Lieblich, Geoffrey L. Hammond, Liisa A.M. Galea
DOI: 10.1016/j.physbeh.2008.09.004
01/2009

In silico identification of anthropogenic chemicals as ligands of zebrafish sex hormone binding globulin
Toxicology and Applied Pharmacology
Nels Thorsteinson, Fuqiang Ban, Osvaldo Santos-Filho, Seyed M.H. Tabaei, Solange Miguel-Queralt, Caroline Underhill, Artem Cherkasov, Geoffrey L. Hammond
DOI: 10.1016/j.taap.2008.07.014
01/2009

Characterization and Measurement of the Plasma a- and ß-Sex Hormone-Binding Globulin Paralogs in Salmon
Endocrinology
Solange Miguel-Queralt, Caroline Underhill, Robert H. Devlin, Geoffrey L. Hammond
DOI: 10.1210/en.2008-0964
01/2009

Residues in the Human Corticosteroid-binding Globulin Reactive Center Loop That Influence Steroid Binding before and after Elastase Cleavage
Journal of Biological Chemistry
Hai-Yan Lin, Caroline Underhill, Bernd R. Gardill, Yves A. Muller, Geoffrey L. Hammond
DOI: 10.1074/jbc.m807376200
11/2008

Sex Hormone-Binding Globulin in Fish Gills Is a Portal for Sex Steroids Breached by Xenobiotics
Endocrinology
Solange Miguel-Queralt, Geoffrey L. Hammond
DOI: 10.1210/en.2008-0384
09/2008

Estrogen Receptor a Gene Polymorphisms Are Associated With Idiopathic Premature Ovarian Failure
Obstetrical & Gynecological Survey
Karla L. Bretherick, Courtney W. Hanna, Lauren M. Currie, Margo R. Fluker, Geoffrey L. Hammond, Wendy P. Robinson
DOI: 10.1097/01.ogx.0000318078.78865.25
07/2008

Two Forms of Sex Hormone-Binding Globulin in Salmonid Blood.
Biology of Reproduction
Solange Miguel-Queralt, Caroline Underhill, Geoffrey L. Hammond
DOI: 10.1093/biolreprod/78.s1.215c
05/2008

An Updated Steroid Benchmark Set and Its Application in the Discovery of Novel Nanomolar Ligands of Sex Hormone-Binding Globulin
Journal of Medicinal Chemistry
Artem Cherkasov, Fuqiang Ban, Osvaldo Santos-Filho, Nels Thorsteinson, Magid Fallahi, Geoffrey L. Hammond
DOI: 10.1021/jm7011485
04/2008

Estrogen receptor a gene polymorphisms are associated with idiopathic premature ovarian failure
Fertility and Sterility
Karla L. Bretherick, Courtney W. Hanna, Lauren M. Currie, Margo R. Fluker, Geoffrey L. Hammond, Wendy P. Robinson
DOI: 10.1016/j.fertnstert.2007.03.008
02/2008

Estetrol does not bind sex hormone binding globulin or increase its production by human HepG2 cells
Climacteric
G. L. Hammond, K. N. Hogeveen, M. Visser, H. J. T. Coelingh Bennink
DOI: 10.1080/13697130701851814
01/2008

Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene
Journal of Clinical Investigation
David M. Selva, Kevin N. Hogeveen, Sheila M. Innis, Geoffrey L. Hammond
DOI: 10.1172/jci32249
11/2007

Sex hormone-binding globulin expression in sea bass (Dicentrarchus labrax L.) throughout development and the reproductive season
Molecular and Cellular Endocrinology
Solange Miguel-Queralt, Mercedes Blázquez, Francesc Piferrer, Geoffrey L. Hammond
DOI: 10.1016/j.mce.2007.06.009
09/2007

Corticosteroid-binding Globulin, a Structural Basis for Steroid Transport and Proteinase-triggered Release
Journal of Biological Chemistry
Michael A. Klieber, Caroline Underhill, Geoffrey L. Hammond, Yves A. Muller
DOI: 10.1074/jbc.m705014200
07/2007

Testicular degeneration in Huntington disease
Neurobiology of Disease
Jeremy M. Van Raamsdonk, Zoe Murphy, David M. Selva, Reza Hamidizadeh, Jacqueline Pearson, ¿sa Petersén, Maria Björkqvist, Cameron Muir, Ian R. Mackenzie, Geoffrey L. Hammond, A. Wayne Vogl, Michael R. Hayden, Blair R. Leavitt
DOI: 10.1016/j.nbd.2007.01.006
06/2007

Steroid Conjugates of Dichloro(6-aminomethylnicotinate)platinum(II): Effects on DNA, Sex Hormone Binding Globulin, the Estrogen Receptor, and Various Breast Cancer Cell Lines
ChemMedChem
Rainer Schobert, Günther Bernhardt, Bernhard Biersack, Susanne Bollwein, Magid Fallahi, Antje Grotemeier, Geoffrey L. Hammond
DOI: 10.1002/cmdc.200600173
03/2007

LETTERS TO THE EDITOR: Do Oral Contraceptives Produce Irreversible Effects on Women's Sexuality?
The Journal of Sexual Medicine
John Bancroft, Geoffrey Hammond, Cynthia Graham
DOI: 10.1111/j.1743-6109.2006.00253.x
05/2006

Steroid Receptor Coactivator-3 Is Required for Progesterone Receptor Trans-activation of Target Genes in Response to Gonadotropin-releasing Hormone Treatment of Pituitary Cells
Journal of Biological Chemistry
Beum-Soo An, David M. Selva, Geoffrey L. Hammond, Adolfo Rivero-Muller, Nafis Rahman, Peter C. K. Leung
DOI: 10.1074/jbc.m600743200
05/2006

Evidence That Fibulin Family Members Contribute to the Steroid-dependent Extravascular Sequestration of Sex Hormone-binding Globulin
Journal of Biological Chemistry
Kwong-Man Ng, Maria G. Catalano, Tomàs Pinós, David M. Selva, George V. Avvakumov, Francina Munell, Geoffrey L. Hammond
DOI: 10.1074/jbc.m512370200
04/2006

Human Sex Hormone-binding Globulin is Expressed in Testicular Germ Cells and not in Sertoli Cells
Hormone and Metabolic Research
D. Selva, G. Hammond
DOI: 10.1055/s-2006-925336
04/2006

Progressive Docking:  A Hybrid QSAR/Docking Approach for Accelerating In Silico High Throughput Screening
Journal of Medicinal Chemistry
Artem Cherkasov, Fuqiang Ban, Yvonne Li, Magid Fallahi, Geoffrey L. Hammond
DOI: 10.1021/jm060961+
2006

‘Inductive' Charges on Atoms in Proteins:  Comparative Docking with the Extended Steroid Benchmark Set and Discovery of a Novel SHBG Ligand
Journal of Chemical Information and Modeling
Artem Cherkasov, Zheng Shi, Yvonne Li, Steven J. M. Jones, Magid Fallahi, Geoffrey L. Hammond
DOI: 10.1021/ci0498158
11/2005

Human Sperm Sex Hormone-Binding Globulin Isoform: Characterization and Measurement by Time-Resolved Fluorescence Immunoassay
The Journal of Clinical Endocrinology & Metabolism
David M. Selva, Lluis Bassas, Francina Munell, Ana Mata, Francis Tekpetey, John G. Lewis, Geoffrey L. Hammond
DOI: 10.1210/jc.2005-1192
11/2005

Successful in Silico Discovery of Novel Nonsteroidal Ligands for Human Sex Hormone Binding Globulin
Journal of Medicinal Chemistry
Artem Cherkasov, Zheng Shi, Magid Fallahi, Geoffrey L. Hammond
DOI: 10.1021/jm049087f
05/2005

Sea bass (Dicentrarchus labrax) sex hormone binding globulin: molecular and biochemical properties and phylogenetic comparison of its orthologues in multiple fish species
Molecular and Cellular Endocrinology
Solange Miguel-Queralt, George V. Avvakumov, Mercedes Blázquez, Francesc Piferrer, Geoffrey L. Hammond
DOI: 10.1016/j.mce.2004.10.004
01/2005

Molecular and Functional Characterization of Sex Hormone Binding Globulin in Zebrafish
Endocrinology
Solange Miguel-Queralt, Michelle Knowlton, George V. Avvakumov, Rana Al-Nouno, Greg M. Kelly, Geoffrey L. Hammond
DOI: 10.1210/en.2004-0678
11/2004

Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study
Breast Cancer Research
Chi-Chen Hong, Bing-Kou Tang, Geoffrey L Hammond, David Tritchler, Martin Yaffe, Norman F Boyd
DOI: 10.1186/bcr798
05/2004

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility
Journal of Lipid Research
David M. Selva, Veronica Hirsch-Reinshagen, Braydon Burgess, Steven Zhou, Jeniffer Chan, Sean McIsaac, Michael R. Hayden, Geoffrey L. Hammond, A. Wayne Vogl, Cheryl L. Wellington
DOI: 10.1194/jlr.m400007-jlr200
03/2004

Repression of the Human Sex Hormone-binding Globulin Gene in Sertoli Cells by Upstream Stimulatory Transcription Factors
Journal of Biological Chemistry
David M. Selva, Kevin N. Hogeveen, Geoffrey L. Hammond
DOI: 10.1074/jbc.m409616200
2004

Association between the T27C polymorphism in the cytochrome P450 c17? (CYP17) gene and risk factors for breast cancer
Breast Cancer Research and Treatment
Chi-chen Hong, Henry J. Thompson, Cheng Jiang, Geoffrey L. Hammond, David Tritchler, Martin Yaffe, Norman F. Boyd
DOI: 10.1007/s10549-004-0780-7
2004

Structure/function analyses of human sex hormone-binding globulin: effects of zinc on steroid-binding specificity
The Journal of Steroid Biochemistry and Molecular Biology
Geoffrey L Hammond, George V Avvakumov, Yves A Muller
DOI: 10.1016/s0960-0760(03)00195-x
06/2003

Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties
Contraception
Geoffrey L. Hammond, Larry S. Abrams, George W. Creasy, Jaya Natarajan, J.Glyn Allen, Pentti K. Siiteri
DOI: 10.1016/s0010-7824(02)00473-0
02/2003

Sex Hormone-Binding Globulin (SHBG)
Encyclopedia of Hormones
Geoffrey L. Hammond, Kevin N. Hogeveen
DOI: 10.1016/b0-12-341103-3/00269-2
2003

The association of breast mitogens with mammographic densities
British Journal of Cancer
N F Boyd, J Stone, L J Martin, R Jong, E Fishell, M Yaffe, G Hammond, S Minkin
DOI: 10.1038/sj.bjc.6600537
10/2002

Crystal Structure of Human Sex Hormone-binding Globulin in Complex with 2-Methoxyestradiol Reveals the Molecular Basis for High Affinity Interactions with C-2 Derivatives of Estradiol
Journal of Biological Chemistry
George V. Avvakumov, Irina Grishkovskaya, Yves A. Muller, Geoffrey L. Hammond
DOI: 10.1074/jbc.m207762200
09/2002

Access of reproductive steroids to target tissues
Obstetrics and Gynecology Clinics of North America
Geoffrey L Hammond
DOI: 10.1016/s0889-8545(02)00008-6
09/2002

A Human Sex Hormone-binding Globulin Isoform Accumulates in the Acrosome during Spermatogenesis
Journal of Biological Chemistry
David M. Selva, Kevin N. Hogeveen, Koji Seguchi, Francis Tekpetey, Geoffrey L. Hammond
DOI: 10.1074/jbc.m205903200
09/2002

18F-labeled difluoroestradiols: preparation and preclinical evaluation as estrogen receptor-binding radiopharmaceuticals
Steroids
Yann Seimbille, Jacques Rousseau, François Bénard, Catherine Morin, Hasrat Ali, George Avvakumov, Geoffrey L Hammond, Johan E van Lier
DOI: 10.1016/s0039-128x(02)00025-9
08/2002

Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
Journal of Biological Chemistry
Irina Grishkovskaya, George V. Avvakumov, Geoffrey L. Hammond, Maria G. Catalano, Yves A. Muller
DOI: 10.1074/jbc.m203999200
06/2002

Resolution of a Disordered Region at the Entrance of the Human Sex Hormone-binding Globulin Steroid-binding Site
Journal of Molecular Biology
Irina Grishkovskaya, George V Avvakumov, Geoffrey L Hammond, Yves A Muller
DOI: 10.1016/s0022-2836(02)00169-9
05/2002

Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction
Journal of Clinical Investigation
Kevin N. Hogeveen, Patrice Cousin, Michel Pugeat, Didier Dewailly, Benoît Soudan, Geoffrey L. Hammond
DOI: 10.1172/jci0214060
04/2002

O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation
Molecular and Cellular Endocrinology
M Raineri, M.G Catalano, G.L Hammond, G.V Avvakumov, R Frairia, N Fortunati
DOI: 10.1016/s0303-7207(01)00725-0
03/2002

Preclinical profiles of progestins used in formulations of oral contraceptives and hormone replacement therapy
American Journal of Obstetrics and Gynecology
Geoffrey L. Hammond, Thomas Rabe, Janice D. Wagner
DOI: 10.1067/mob.2001.117415
08/2001

Human Sex Hormone-binding Globulin Promoter Activity Is Influenced by a (TAAAA)nRepeat Element within anAluSequence
Journal of Biological Chemistry
Kevin N. Hogeveen, Marja Talikka, Geoffrey L. Hammond
DOI: 10.1074/jbc.m104681200
07/2001

Resolution of the Human Sex Hormone-binding Globulin Dimer Interface and Evidence for Two Steroid-binding Sites per Homodimer
Journal of Biological Chemistry
George V. Avvakumov, Irina Grishkovskaya, Yves A. Muller, Geoffrey L. Hammond
DOI: 10.1074/jbc.m106274200
07/2001

Steroid-binding Specificity of Human Sex Hormone-binding Globulin Is Influenced by Occupancy of a Zinc-binding Site
Journal of Biological Chemistry
George V. Avvakumov, Yves A. Muller, Geoffrey L. Hammond
DOI: 10.1074/jbc.m004484200
06/2000

Estrogen receptor- and aryl hydrocarbon receptor-mediated activities of a coal-tar creosote
Environmental Toxicology and Chemistry
Mark R. Fielden, Zhi-Fen Wu, Christopher J. Sinal, Heather Hodgert Jury, John R. Bend, Geoffrey L. Hammond, Tim R. Zacharewski
DOI: 10.1002/etc.5620190507
05/2000

The Rabbit Sex Hormone-Binding Globulin Gene: Structural Organization and Characterization of Its 5'-Flanking Region1
Endocrinology
Ying-Chi Ip, Will M. Lee, Geoffrey L. Hammond
DOI: 10.1210/endo.141.4.7406
04/2000

Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain
The EMBO Journal
Irina Grishkovskaya, George V. Avvakumov, Gisela Sklenar, David Dales, Geoffrey L. Hammond, Yves A. Muller
DOI: 10.1093/emboj/19.4.504
02/2000

Novel Human Corticosteroid-Binding Globulin Variant with Low Cortisol-Binding Affinity1
The Journal of Clinical Endocrinology & Metabolism
Agnes Emptoz-Bonneton, Patrice Cousin, Koji Seguchi, George V. Avvakumov, Chantal Bully, Geoffrey L. Hammond, Michel Pugeat
DOI: 10.1210/jcem.85.1.6315
01/2000

Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands
The Journal of Steroid Biochemistry and Molecular Biology
Heather Hodgert Jury, Tim R. Zacharewski, Geoffrey L. Hammond
DOI: 10.1016/s0960-0760(00)00168-0
2000

The shbg gene and hormone dependence of Breast Cancer: A novel mechanism of hormone dependence of MCF-7 human breast cancer cells based upon SHBG
Breast Cancer
Yoichi Murayama, Geoffrey L. Hammond, Kenichi Sugihara
DOI: 10.1007/bf02966450
10/1999

Expression and Regulation of Human Sex Hormone-Binding Globulin Transgenes in Mice during Development
Endocrinology
Marja Jänne and Kevin N. Hogeveen and Harminder K. Deol and Geoffrey L. Hammond
DOI: 10.1210/endo.140.9.7004
09/1999

Influence of glycosylation on the clearance of recombinant human sex hormone-binding globulin from rabbit blood
The Journal of Steroid Biochemistry and Molecular Biology
Patrice Cousin, Henri Déchaud, Catherine Grenot, Hervé Lejeune, Geoffrey L. Hammond, Michel Pugeat
DOI: 10.1016/s0960-0760(99)00101-6
09/1999

N-glycans are not the signal for apical sorting of corticosteroid binding globulin in MDCK cells
FEBS Letters
Jakob E. Larsen, George V. Avvakumov, Geoffrey L. Hammond, Lotte K. Vogel
DOI: 10.1016/s0014-5793(99)00526-8
05/1999

Identification of a Locus on Distal Mouse Chromosome 12 That Controls Resistance to Tumor Necrosis Factor-Induced Lethal Shock
Genomics
Claude Libert, Ben Wielockx, Geoffrey L. Hammond, Peter Brouckaert, Walter Fiers, Rosemary W. Elliott
DOI: 10.1006/geno.1998.5677
02/1999

Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood
Acta Crystallographica Section D Biological Crystallography
Irina Grishkovskaya, Gisela Sklenar, George V. Avvakumov, David Dales, Joachim Behlke, Geoffrey L. Hammond, Yves A. Muller
DOI: 10.1107/s0907444999012883
1999

Control of the Membrane Sex Hormone-Binding Globulin-Receptor (SHBG-R) in MCF-7 Cells: Effect of Locally Produced SHBG
Steroids
Nicoletta Fortunati, Mariangela Raineri, Alessandro Cignetti, Geoffrey L. Hammond, Roberto Frairia
DOI: 10.1016/s0039-128x(98)00021-x
05/1998

Establishment of a Mouse Sertoli Cell Line Producing Rat Androgen-binding Protein (ABP)
Steroids
Angélique Ducray, Michèle Bloquel, Ketsia Hess, Geoffrey L. Hammond, Hubert Gérard, Anne Gérard
DOI: 10.1016/s0039-128x(98)00030-0
05/1998

Divergent changes in plasma ACTH and pituitary POMC mRNA after cortisol administration to late-gestation ovine fetus
American Journal of Physiology-Endocrinology and Metabolism
T. M. Jeffray, S. G. Matthews, G. L. Hammond, J. R. G. Challis
DOI: 10.1152/ajpendo.1998.274.3.e417
03/1998

Human Sex Hormone-Binding Globulin Gene Expression in Transgenic Mice
Molecular Endocrinology
Marja Jänne, Harminder K. Deol, Stephen G. A. Power, Siu-Pok Yee, Geoffrey L. Hammond
DOI: 10.1210/mend.12.1.0050
01/1998

Hepatocyte Nuclear Factor-4 Controls Transcription from a TATA-less Human Sex Hormone-binding Globulin Gene Promoter
Journal of Biological Chemistry
Marja Jänne, Geoffrey L. Hammond
DOI: 10.1074/jbc.273.51.34105
1998

Effects of a low-fat high-carbohydrate diet on plasma sex hormones in premenopausal women: results from a randomized controlled trial
British Journal of Cancer
NF Boyd, for the Canadian Diet and Breast Cancer Prevention Study Group (See Appendix I), GA Lockwood, CV Greenberg, LJ Martin, DL Tritchler
DOI: 10.1038/bjc.1997.348
07/1997

The effects of estradiol-17° infusion into fetal sheep in late gestation
Endocrine
Sheila Wang, Stephen G. Matthews, Treena M. Jeffray, M. Yvette Stevens, Kaiping Yang, Geoffrey L. Hammond, John R. G. Challis
DOI: 10.1007/bf02820503
06/1997

Rabbit sex hormone binding globulin: primary structure, tissue expression, and structure/function analyses by expression in Escherichia coli
Journal of Endocrinology
W M Lee, A S T Wong, A W K Tu, C-H Cheung, J C H Li, G L Hammond
DOI: 10.1677/joe.0.1530373
06/1997

Hepatic nuclear proteins that bind cis-regulatory elements in the proximal promoter of the rat corticosteroid-binding globulin gene
Molecular and Cellular Endocrinology
Xian-Feng Zhao, D.Alan Underhill, Geoffrey L Hammond
DOI: 10.1016/s0303-7207(96)03992-5
02/1997

Glucocorticoids induce corticosteroid-binding globulin biosynthesis by immature mouse liver and kidney
The Journal of Steroid Biochemistry and Molecular Biology
Xian-Feng Zhao, Louise A. Scrocchi, Geoffrey L. Hammond
DOI: 10.1016/s0960-0760(96)00181-1
02/1997

Differential Effects of Betamethasone and Dexamethasone Fetal Administration of Parturition in Sheep
Journal of the Society for Gynecologic Investigation
Jan B. Derks, Dino A. Giussani, Lecia M. Van Dam, Susan L. Jenkins, James A. Winter, Xian F. Zhao, Geoffrey L. Hammond, Peter W. Nathanielsz
DOI: 10.1177/107155769600300607
11/1996

Developmental regulation of corticosteroid-binding globulin biosynthesis in the baboon fetus.
Endocrinology
G J Pepe, H H Jury, G L Hammond, E D Albrecht
DOI: 10.1210/endo.137.8.8754758
08/1996

Murine corticosteroid binding globulin localizes to early embryo trophoblasts
Placenta
M.G. Baines, E. Antecka, G.L. Hammond
DOI: 10.1016/s0143-4004(96)90241-6
07/1996

Growth Response of Adult Germ Cells to Rat Androgen-Binding Protein and Human Sex Hormone-Binding Globulin
Hormone Research
A. Gérard, R. Bedjou, A. Clerc, F. Maachi, J. Closset, G.L. Hammond, F. Nabet, H. Gérard
DOI: 10.1159/000184791
1996

Sex Hormone-Binding Globulin: Gene Organization and Structure/Function Analyses
Hormone Research
Geoffrey L. Hammond, Wayne P. Bocchinfuso
DOI: 10.1159/000184787
1996

Potential functions of plasma steroid-binding proteins
Trends in Endocrinology & Metabolism
Geoffrey L. Hammond
DOI: 10.1016/1043-2760(95)00162-x
11/1995

cis-Regulatory elements within the proximal promoter of the rat gene encoding corticosteroid-binding globulin
Gene
D. Alan Underhill, Geoffrey L. Hammond
DOI: 10.1016/0378-1119(95)00337-6
09/1995

Corticosteroid-binding globulin (CBG) production by hepatic and extra-hepatic sites in the ovine fetus; effects of CBG on glucocorticoid negative feedback on pituitary cells in vitro
Journal of Endocrinology
E T M Berdusco, K Yang, G L Hammond, J R G Challis
DOI: 10.1677/joe.0.1460121
07/1995

Sex hormone-binding globulin/androgen-binding protein: Steroid-binding and dimerization domains
The Journal of Steroid Biochemistry and Molecular Biology
Geoffrey L. Hammond, Wayne P. Bocchinfuso
DOI: 10.1016/0960-0760(95)00110-l
06/1995

Resolution of the steroid-binding and dimerization domains of human sex hormone-binding globulin by expression in Escherichia coli
Biochemistry
Catherine Hildebrand, Wayne P. Bocchinfuso, David Dales, Geoffrey L. Hammond
DOI: 10.1021/bi00010a012
03/1995

Serum distribution of two contraceptive progestins: 3-ketodesogestrel and gestodene
Contraception
G.L Hammond, W.P Bocchinfuso, M Orava, C.L Smith, A Van Den Ende, A. Van Enk
DOI: 10.1016/0010-7824(94)90018-3
10/1994

Steroid-Binding and Dimerization Domains of Human Sex Hormone-Binding Globulin Partially Overlap: Steroids and Ca2+ Stabilize Dimer Formation
Biochemistry
Wayne P. Bocchinfuso, Geoffrey L. Hammond
DOI: 10.1021/bi00201a008
09/1994

Structure and chromosomal location of the gene encoding mouse corticosteroid-binding globulin: strain differences in coding sequence and steroid-binding activity
Gene
Mauri Orava, Xian F. Zhao, Edward Leiter, Geoffrey L. Hammond
DOI: 10.1016/0378-1119(94)90387-5
07/1994

Substitutions of tryptophan residues in human corticosteroid-binding globulin: Impact on steroid binding and glycosylation
The Journal of Steroid Biochemistry and Molecular Biology
George V. Avvakumov, Geoffrey L. Hammond
DOI: 10.1016/0960-0760(94)90010-8
06/1994

Glycosylation of Human Corticosteroid-Binding Globulin. Differential Processing and Significance of Carbohydrate Chains at Individual Sites
Biochemistry
George V. Avvakumov, Geoffrey L. Hammond
DOI: 10.1021/bi00185a012
05/1994

Squirrel monkey corticosteroid-binding globulin: primary structure and comparison with the human protein
Endocrinology
G. L. Hammond
DOI: 10.1210/en.134.2.891
02/1994

Tissue Distribution of a1-Proteinase Inhibitor Messenger Ribonucleic Acid and its Regulation by Glucocorticoids in Fetal and Neonatal Sheep1
Biology of Reproduction
Edward T.M. Berdusco, Kaiping Yang, John R.G. Challis, Geoffrey L. Hammond
DOI: 10.1095/biolreprod49.4.816
10/1993

Interleukin-6 inhibits corticosteroid-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells.
Endocrinology
L Bartalena, G L Hammond, A Farsetti, I L Flink, J Robbins
DOI: 10.1210/endo.133.1.8391424
07/1993

Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93
Steroids
Hugo Van Baelen, Stephen G.A. Power, Geoffrey L. Hammond
DOI: 10.1016/0039-128x(93)90072-u
06/1993

Glucocorticoid-induced increase in plasma corticosteroid-binding globulin levels in fetal sheep is associated with increased biosynthesis and alterations in glycosylation.
Endocrinology
E T Berdusco, G L Hammond, R A Jacobs, A Grolla, K Akagi, D Langlois, J R Challis
DOI: 10.1210/endo.132.5.8477651
05/1993

Corticosteroid-binding globulin biosynthesis in the mouse liver and kidney during postnatal development.
Endocrinology
L A Scrocchi, S A Hearn, V K Han, G L Hammond
DOI: 10.1210/endo.132.2.8425503
02/1993

Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice.
Endocrinology
L A Scrocchi, M Orava, C L Smith, V K Han, G L Hammond
DOI: 10.1210/endo.132.2.7916682
02/1993

Effect of burn injury on corticosteroid-binding globulin levels in plasma and wound fluid
Wound Repair and Regeneration
Limin Zhang, Xian-F Zhao, Geoffrey L Hammond
DOI: 10.1046/j.1524-475x.1993.10105.x
01/1993

Selective removal of glycosylation sites from sex hormone-binding globulin by site-directed mutagenesis.
Endocrinology
W P Bocchinfuso, K L Ma, W M Lee, S Warmels-Rodenhiser, G L Hammond
DOI: 10.1210/endo.131.5.1425432
11/1992

Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development.
Endocrinology
K Yang, C L Smith, D Dales, G L Hammond, J R Challis
DOI: 10.1210/endo.131.5.1425412
11/1992

Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain.
The Journal of Clinical Endocrinology & Metabolism
S G Power, W P Bocchinfuso, M Pallesen, S Warmels-Rodenhiser, H Van Baelen, G L Hammond
DOI: 10.1210/jcem.75.4.1400872
10/1992

A Leu ¿ His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol
The Journal of Steroid Biochemistry and Molecular Biology
Carolyn L. Smith, Stephen G.A. Power, Geoffrey L. Hammond
DOI: 10.1016/0960-0760(92)90107-t
08/1992

Structure/function analyses of human sex hormone-binding globulin by site-directed mutagenesis
FEBS Letters
W.P. Bocchinfuso, S. Warmels-Rodenhiser, G.L. Hammond
DOI: 10.1016/0014-5793(92)81253-i
04/1992

Characterization of an ovine glucocorticoid receptor cDNA and developmental changes in its mRNA levels in the fetal sheep hypothalamus, pituitary gland and adrenal
Journal of Molecular Endocrinology
K. Yang, G. L. Hammond, J. R. G. Challis
DOI: 10.1677/jme.0.0080173
04/1992

Hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat.
Endocrinology
C L Smith, G L Hammond
DOI: 10.1210/endo.130.4.1547738
04/1992

Novel Testicular Products of the Human SHBG/ABP Gene
Follicle Stimulating Hormone
Geoffrey L. Hammond
DOI: 10.1007/978-1-4684-7103-8_21
1992

Expression and Differential Glycosylation of Human Sex Hormone-Binding Globulin by Mammalian Cell Lines
Molecular Endocrinology
Wayne P. Bocchinfuso, Susan Warmels-Rodenhiser, Geoffrey L. Hammond
DOI: 10.1210/mend-5-11-1723
11/1991

Levels of Surfactant-Associated Protein Messenger Ribonucleic Acids in Rabbit Lung during Perinatal Development and after Hormonal Treatment*
Endocrinology
IAN H. CONNELLY, GEOFFREY L. HAMMOND, PAUL G. R. HARDING, FRED POSSMAYER
DOI: 10.1210/endo-129-5-2583
11/1991

Effect of Adrenocorticotropin Administration on the Biosynthesis of Corticosteroid-Binding Globulin in Fetal Sheep
Endocrinology
ROSS A. JACOBS and VICTOR K.M. HAN and GEOFFREY L. HAMMOND and JOHN R.G. CHALLIS
DOI: 10.1210/endo-128-4-1960
04/1991

Ontogeny of Corticosteroid-Binding Globulin Biosynthesis in the Rat*
Endocrinology
CAROLYN L. SMITH, GEOFFREY L. HAMMOND
DOI: 10.1210/endo-128-2-983
02/1991

Molecular studies of corticosteroid binding globulin structure, biosynthesis and function
The Journal of Steroid Biochemistry and Molecular Biology
G.L. Hammond, C.L. Smith, D.A. Underhill
DOI: 10.1016/0960-0760(91)90300-t
01/1991

Pro-opiomelanocortin messenger RNA levels increase in the fetal sheep pituitary during late gestation
Journal of Endocrinology
K. Yang, J. R. G. Challis, V. K. M. Han, G. L. Hammond
DOI: 10.1677/joe.0.1310483
1991

The human corticosteroid binding globulin gene is located on chromosome 14q31?q32.1 near two other serine protease inhibitor genes
Human Genetics
Gilles-Eric Seralini, Dominique B¿rub¿, Richard Gagn¿, GeoffreyL. Hammond
DOI: 10.1007/bf00205177
11/1990

Interaction between corticosteroid binding globulin and activated leukocytes in vitro
Biochemical and Biophysical Research Communications
Geoffrey L. Hammond, Carolyn L. Smith, Caroline M. Underhill, Vi T.T. Nguyen
DOI: 10.1016/s0006-291x(05)80189-5
10/1990

Rabbit Corticosteroid-Binding Globulin: Primary Structure and Biosynthesis during Pregnancy
Molecular Endocrinology
Gilles-Eric Seralini, Carolyn L. Smith, Geoffrey L. Hammond
DOI: 10.1210/mend-4-8-1166
08/1990

A Role for Corticosteroid-Binding Globulin in Delivery of Cortisol to Activated Neutrophils*
The Journal of Clinical Endocrinology & Metabolism
GEOFFREY L. HAMMOND, CAROLYN L. SMITH, NIGEL A. M. PATERSON, WILLIAM J. SIBBALD
DOI: 10.1210/jcem-71-1-34
07/1990

Molecular Properties of Corticosteroid Binding Globulin and the Sex-Steroid Binding Proteins
Endocrine Reviews
GEOFFREY L. HAMMOND
DOI: 10.1210/edrv-11-1-65
02/1990

Expression of mature pulmonary surfactant-associated protein B (SP-B) in Escherichia coli using truncated human SP-B cDNAs
Biochemistry and Cell Biology
Li-Juan Yao, Carol Richardson, Carol Ford, N. Mathialagan, George Mackie, Geoffrey L. Hammond, Paul G. R. Harding, Fred Possmayer
DOI: 10.1139/o90-080
02/1990

The Human Sex Hormone-Binding Globulin Gene Contains Exons for Androgen-Binding Protein and Two Other Testicular Messenger RNAs
Molecular Endocrinology
Geoffrey L. Hammond, D. Alan Underbill, Harriet M. Rykse, Carolyn L. Smith
DOI: 10.1210/mend-3-11-1869
11/1989

Biological Half-Life and Transfer of Maternal Corticosteroid-Binding Globulin to Amniotic Fluid in the Rabbit*
Endocrinology
GILLES-ERIC SERALINI, CAROLINE M. UNDERHILL, CAROLYN L. SMITH, VI T. T. NGUYEN, GEOFFREY L. HAMMOND
DOI: 10.1210/endo-125-3-1321
09/1989

Organization of the Human Corticosteroid Binding Globulin Gene and Analysis of Its 5'-Flanking Region
Molecular Endocrinology
D. Alan Underhill, Geoffrey L. Hammond
DOI: 10.1210/mend-3-9-1448
09/1989

Identification of Proteins Immunochemically Related to Human Pregnancy-Specific ß1-Glycoprotein in the Rat Placenta
Endocrinology
S. OGILVIE and A. G. KVELLO-STENSTROM and G. HAMMOND and W. C. BUHI and L. H. LARKIN and K. T. SHIVERICK
DOI: 10.1210/endo-125-1-287
07/1989

Isolation and characterization of the cDNA for pulmonary surfactant-associated protein-B (SP-B) in the rabbit
Biochemical and Biophysical Research Communications
Jiejing Xu, Carol Richardson, Carol Ford, Tina Spencer, Yao Li-juan, George Mackie, Geoffrey Hammond, Fred Possmayer
DOI: 10.1016/0006-291x(89)91659-8
04/1989

Rat Corticosteroid Binding Globulin: Primary Structure and Messenger Ribonucleic Acid Levels in the Liver under Different Physiological Conditions
Molecular Endocrinology
Carolyn L. Smith, Geoffrey L. Hammond
DOI: 10.1210/mend-3-2-420
02/1989

The amino acid sequence of rat CBG deduced from a cDNA, and identification of CBG mRNA in the liver under different physiological states
Steroids
Carolyn L. Smith, Geoffrey L. Hammond
DOI: 10.1016/0039-128x(88)90132-8
10/1988

Isolation and characterization of the structural region of the human CBG gene
Steroids
D.Alan Underhill, Geoffrey L. Hammond
DOI: 10.1016/0039-128x(88)90131-6
10/1988

Molecular Analyses of Human Corticosteroid-Binding Globulin.Expression and Gene Structurea
Annals of the New York Academy of Sciences
GEOFFREY L. HAMMOND
DOI: 10.1111/j.1749-6632.1988.tb48845.x
09/1988

Hormonal Regulation of Rat Androgen-Binding Protein (ABP) Messenger Ribonucleic Acid and Homology of Human Testosterone-Estradiol-Binding Globulin and ABP Complementary Deoxyribonucleic Acids
Molecular Endocrinology
Jaume Reventos, Geoffrey L. Hammond, Anne Crozat, David E. Brooks, Glen L. Gunsalus, C. Wayne Bardin, Neal A. Musto
DOI: 10.1210/mend-2-2-125
02/1988

Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors
Journal of Steroid Biochemistry
C.Wayne Bardin, Glen L. Gunsalus, Neal A. Musto, C.Yan Cheng, Jaume Reventos, Carolyn Smith, D.Alan Underhill, Geoffrey Hammond
DOI: 10.1016/0022-4731(88)90085-4
01/1988

Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.
Proceedings of the National Academy of Sciences
G. L. Hammond, C. L. Smith, I. S. Goping, D. A. Underhill, M. J. Harley, J. Reventos, N. A. Musto, G. L. Gunsalus, C. W. Bardin
DOI: 10.1073/pnas.84.15.5153
08/1987

The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain
FEBS Letters
G.L. Hammond, D.A. Underhill, C.L. Smith, I.S. Goping, M.J. Harley, N.A. Musto, C.Y. Cheng, C.W. Bardin
DOI: 10.1016/0014-5793(87)80121-7
05/1987

Plasma levels of cortisol and corticosteroid binding globulin during use of norplantr -2 implants
Contraception
S-E Olsson, V Odlind, GL Hammond
DOI: 10.1016/0010-7824(87)90072-2
04/1987

Isolation and Characterization of cDNA Probes for Human CBG and Rat ABP
Gene Regulation by Steroid Hormones III
G. L. Hammond, J. Reventos, N. A. Musto, G. L. Gunsalus, C. W. Bardin
DOI: 10.1007/978-1-4612-4686-2_10
1987

Identification and measurement of sex hormone binding globulin1 (SHBG) and corticosteroid binding globulin2 (CBG) in human saliva
European Journal of Endocrinology
G. L. Hammond, M. S. Langley
DOI: 10.1530/acta.0.1120603
08/1986

Physicochemical characteristics of human sex hormone binding globulin: Evidence for two identical subunits
Journal of Steroid Biochemistry
Geoffrey L. Hammond, Philip A. Robinson, Hiromu Sugino, Darrell N. Ward, Jukka Finne
DOI: 10.1016/0022-4731(86)90442-5
04/1986

Serum Steroid Binding Proteins and the Bioavailability of Estradiol in Relation to Breast Diseases2
JNCI: Journal of the National Cancer Institute
Mark S. Langley, Geoffrey L. Hammond, Alan Bardsley, Ronald A. Sellwood, David C. Anderson
DOI: 10.1093/jnci/75.5.823
11/1985

A liquid-phase immunoradiometric assay (IRMA) for human sex hormone binding globulin (SHBG)
Journal of Steroid Biochemistry
G.L. Hammond, M.S. Langley, P.A. Robinson
DOI: 10.1016/0022-4731(85)90192-x
10/1985

A phylogenetic study of the structural and functional characteristics of corticosteroid binding globulin in primates
Journal of Endocrinology
P. A. Robinson, C. Hawkey, G. L. Hammond
DOI: 10.1677/joe.0.1040251
02/1985

Identification and characterization of a human corticosteroid binding globulin variant with a reduced affinity for cortisol
Journal of Endocrinology
P. A. Robinson, G. L. Hammond
DOI: 10.1677/joe.0.1040269
02/1985

A solid-phase radioimmunoassay for human corticosteroid binding globulin
Journal of Endocrinology
P. A. Robinson, M. S. Langley, G. L. Hammond
DOI: 10.1677/joe.0.1040259
02/1985

Sex hormone-binding globulin—still many questions
Scandinavian Journal of Clinical and Laboratory Investigation
GÖRan Lindstedt, Per-Arne Lundberg, Geoffrey Lewis Hammond, Reijo Vihko
DOI: 10.3109/00365518509160964
01/1985

Serum steroid binding protein concentrations, distribution of progestogens, and bioavailability of testosterone during treatment with contraceptives containing desogestrel or levonorgestrel**Supported by a grant from Organon Scientific Development Group, Oss, The Netherlands.
Fertility and Sterility
Geoffrey L. Hammond, Mark S. Langley, Philip A. Robinson, Simo Nummi, Leif Lund
DOI: 10.1016/s0015-0282(16)47956-2
07/1984

Characterization of a monoclonal antibody to human sex hormone binding globulin
FEBS Letters
G.L. Hammond, P.A. Robinson
DOI: 10.1016/0014-5793(84)80268-9
03/1984

A versatile method for the determination of serum cortisol binding globulin and sex hormone binding globulin binding capacities
Clinica Chimica Acta
Geoffrey L. Hammond, Pertti L.A. Lähteenmäki
DOI: 10.1016/0009-8981(83)90237-1
07/1983

MEASUREMENT OF SEX HORMONE BINDING GLOBULIN IN HUMAN AMNIOTIC FLUID: ITS RELATIONSHIP TO PROTEIN AND TESTOSTERONE CONCENTRATIONS, AND FETAL SEX
Clinical Endocrinology
G. L. HAMMOND, P. LEINONEN, N. J. BOLTON, R. VIHKO
DOI: 10.1111/j.1365-2265.1983.tb00582.x
04/1983

Progesterone, androstenedione, testosterone, 5a-dihydrotestosterone and androsterone concentrations in specific regions of the human brain
Journal of Steroid Biochemistry
G.L. Hammond, J. Hirvonen, R. Vihko
DOI: 10.1016/0022-4731(83)90086-9
02/1983

Distribution and percentages of non-protein bound contraceptive steroids in human serum
Journal of Steroid Biochemistry
Geoffrey L. Hammond, Pertti L.A. Lähteenmäki, Pekka Lähteenmäki, Tapani Luukkainen
DOI: 10.1016/0022-4731(82)90629-x
10/1982

Serum concentrations of total and non-protein-bound oestradiol in patients with breast cancer and in normal controls
International Journal of Cancer
J. W. Moore, G. M. G. Clark, R. D. Bulbrook, J. L. Hayward, J. T. Murai, G. L. Hammond, P. K. Siiteri
DOI: 10.1002/ijc.2910290105
01/1982

The Serum Transport of Steroid Hormones
Proceedings of the 1981 Laurentian Hormone Conference
PENTTI K. SIITERI, JAMES T. MURAI, WILLIAM J. RAYMOURE, ROBERT W. KUHN, GEOFFREY L. HAMMOND, JEFFREY A. NISKER
DOI: 10.1016/b978-0-12-571138-8.50016-0
1982

DISTRIBUTION AND CONCENTRATIONS OF ANDROGENS IN EPITHELIAL AND STROMAL COMPARTMENTS OF THE HUMAN BENIGN HYPERTROPHIC PROSTATE
Journal of Endocrinology
N. J. BOLTON, R. LAHTONEN, G. L. HAMMOND, R. VIHKO
DOI: 10.1677/joe.0.0900125
07/1981

Free Estradiol in Postmenopausal Women with and without Endometrial Cancer
The Journal of Clinical Endocrinology & Metabolism
B. J. DAVIDSON and J. C GAMBONE and L. D. LAGASSE and T. W. CASTALDO and G. L. HAMMOND and P. K. SIITERI and H. L. JUDD
DOI: 10.1210/jcem-52-3-404
03/1981

Long-Term Effects of Endocrine Treatment on Serum Pituitary Hormones in Advanced Prostatic Carcinoma Patients
Scandinavian Journal of Urology and Nephrology
O. Lukkarinen, G. L. Hammond, M. Kontturi, R. Vihko
DOI: 10.3109/00365598109179604
01/1981

Serum sex hormone-binding globulin capacity and the percentage of free estradiol in postmenopausal women with and without endometrial carcinoma
American Journal of Obstetrics and Gynecology
J.A. Nisker, G.L. Hammond, B.J. Davidson, A.M. Frumar, N.K. Takaki, H.L. Judd, P.K. Siiteri
DOI: 10.1016/0002-9378(80)90080-0
11/1980

EFFECT OF OESTROGEN TREATMENT ON TESTICULAR LH/hCG RECEPTORS AND ENDOGENOUS STEROIDS IN PROSTATIC CANCER PATIENTS
Clinical Endocrinology
I. HUHTANIEMI, P. LEINONEN, G. L. HAMMOND, R. VIHKO
DOI: 10.1111/j.1365-2265.1980.tb03424.x
1980

SERUM PREGNENOLONE, PROGESTERONE, 17a-HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5a-DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS
Clinical Endocrinology
A. PAKARINEN, G. L. HAMMOND, R. VIHKO
DOI: 10.1111/j.1365-2265.1979.tb03098.x
11/1979

ADRENOCORTICAL FUNCTION IN PUBERTY Serum ACTH, Cortisol and Dehydroepiandrosterone in Girls and Boys
Acta Paediatrica
D. APTER, A. PAKARINEN, G. L. HAMMOND, R. VIHKO
DOI: 10.1111/j.1651-2227.1979.tb05062.x
09/1979

Automation of steroid radioimmunoassays for clinical and research purposes
Journal of Steroid Biochemistry
R. Vihko, G.L. Hammond
DOI: 10.1016/0022-4731(79)90286-3
07/1979

THE HORMONAL STATUS OF PATIENTS WITH BENIGN PROSTATIC HYPERTROPHY: FSH, LH, TSH AND PROLACTIN RESPONSES TO RELEASING HORMONES
Clinical Endocrinology
G. L. HAMMOND, O. LUKKARINEN, P. VIHKO, M. KONTTURI, R. VIHKO
DOI: 10.1111/j.1365-2265.1979.tb02113.x
06/1979

SERUM STEROIDS IN NORMAL MALES AND PATIENTS WITH PROSTATIC DISEASES
Clinical Endocrinology
G. L. HAMMOND, M. KONTTURI, P. VIHKO, R. VIHKO
DOI: 10.1111/j.1365-2265.1978.tb02189.x
08/1978

Endogenous steroid levels in the human prostate from birth to old age: a comparison of normal and diseased tissues
Journal of Endocrinology
G. L. HAMMOND
DOI: 10.1677/joe.0.0780007
07/1978

The Radioimmunoassay of Testosterone, 5a-Dihydrotestosterone and Their Precursors in the Human Testis
International Journal of Andrology
G. L. Hammond, V. Ahonen, R. Vihko
DOI: 10.1111/j.1365-2605.1978.tb00031.x
06/1978

The Simultaneous Radioimmunoassay of Seven Steroids in Human Spermatic and Peripheral Venous Blood
The Journal of Clinical Endocrinology & Metabolism
G. L. HAMMOND, A. RUOKONEN, M. KONTTURI, E. KOSKELA, R. VIHKO
DOI: 10.1210/jcem-45-1-16
07/1977

METAL-ANDROGEN INTERRELATIONSHIPS IN CARCINOMA AND HYPERPLASIA OF THE HUMAN PROSTATE
Journal of Endocrinology
F. K. HABIB, G. L. HAMMOND, I. R. LEE, J. B. DAWSON, M. K. MASON, P. H. SMITH, S. R. STITCH
DOI: 10.1677/joe.0.0710133
10/1976