Overview

I am interested to find out how we can design health care innovations that can be easily picked up and utilized by healthcare providers and health organizations and evaluating whether those innovations have been effective in creating change. Also, I am interested in studying the roll-out of innovations in the health care system and the community and finding ways we can facilitate the roll-out to make it more effective and efficient.

Publications

Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
Science Translational Medicine
Riba, A. and Hassani, K. and Walker, A. and van Best, N. and von Zeschwitz, D. and Anslinger, T. and Sillner, N. and Rosenhain, S. and Eibach, D. and Maiga-Ascofar{\'e}, O. and Rolle-Kampczyk, U. and Basic, M. and Binz, A. and Mocek, S. and Sodeik, B. and Bauerfeind, R. and Mohs, A. and Trautwein, C. and Kiessling, F. and May, J. and Klingenspor, M. and Gremse, F. and Schmitt-Kopplin, P. and Bleich, A. and Torow, N. and von Bergen, M. and Hornef, M.W.
DOI: 10.1126/scitranslmed.aay7019
2020

Capacity building and mentorship among pan-Canadian early career researchers in community-based primary health care
Primary Health Care Research and Development
Nicholson, K. and Ganann, R. and Bookey-Bassett, S. and Garland Baird, L. and Garnett, A. and Marshall, Z. and Khan, A.I. and Pirrie, M. and Sasseville, M. and Ben Charif, A. and Poitras, M.-E. and Kyoon-Achan, G. and Dionne, ?. and Hassani, K. and Stewart, M.
DOI: 10.1017/S1463423619000938
2020

Implementing appetite to play at scale in british columbia: Evaluation of a capacity-building intervention to promote physical activity in the early years
International Journal of Environmental Research and Public Health
Hassani, K. and Buckler, E.J. and McConnell-Nzunga, J. and Fakih, S. and Scarr, J. and M{\^a}sse, L.C. and Naylor, P.-J.
DOI: 10.3390/ijerph17041132
2020

Implementation study of a 5-component pediatric early warning system (PEWS) in an emergency department in British Columbia, Canada, to inform provincial scale up
BMC Emergency Medicine
McElroy, T. and Swartz, E.N. and Hassani, K. and Waibel, S. and Tuff, Y. and Marshall, C. and Chan, R. and Wensley, D. and O{'}Donnell, M.
DOI: 10.1186/s12873-019-0287-5
2019

Contextual factors influencing the implementation of innovations in community-based primary health care: the experience of 12 Canadian research teams
Primary health care research & development
Ploeg, J. and Wong, S.T. and Hassani, K. and Yous, M.-L. and Fortin, M. and Kendall, C. and Liddy, C. and Markle-Reid, M. and Petrovic, B. and Dionne, E. and Scott, C.M. and Wodchis, W.P.
DOI: 10.1017/S1463423619000483
2019

Models of care for traumatically injured patients at trauma centres in British Columbia: Variability and sustainability
Canadian Journal of Emergency Medicine
Tuyp, B. and Hassani, K. and Constable, L. and Haegert, J.
DOI: 10.1017/cem.2017.50
2018

Promoting cross-jurisdictional primary health care research: Developing a set of common indicators across 12 community-based primary health care teams in Canada
Primary Health Care Research and Development
Wong, S.T. and Langton, J.M. and Katz, A. and Fortin, M. and Godwin, M. and Green, M. and Grunfeld, E. and Hassani, K. and Kendall, C. and Liddy, C. and Ploeg, J. and Wodchis, W.P. and Haggerty, J.L.
DOI: 10.1017/S1463423618000518
2018

Continuing Trauma Care after Discharge, the Experience of Outpatient Trauma Clinics in British Columbia
Journal of Trauma Nursing
Tuyp, B. and Hassani, K. and Thurston, C. and Fyvie, K. and Constable, L.
DOI: 10.1097/JTN.0000000000000355
2018

Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions
Cellular Immunology
Atayde, V.D. and Hassani, K. and da Silva Lira Filho, A. and Borges, A.R. and Adhikari, A. and Martel, C. and Olivier, M.
DOI: 10.1016/j.cellimm.2016.07.013
2016

Active suppression of intestinal CD4 + TCRaß + T-lymphocyte maturation during the postnatal period
Nature Communications
Torow, N. and Yu, K. and Hassani, K. and Freitag, J. and Schulz, O. and Basic, M. and Brennecke, A. and Sparwasser, T. and Wagner, N. and Bleich, A. and Lochner, M. and Weiss, S. and F{\"o}rster, R. and Pabst, O. and Hornef, M.W.
DOI: 10.1038/ncomms8725
2015

Exosome Secretion by the Parasitic Protozoan Leishmania within the Sand Fly Midgut
Cell Reports
Atayde, V.D. and Aslan, H. and Townsend, S. and Hassani, K. and Kamhawi, S. and Olivier, M.
DOI: 10.1016/j.celrep.2015.09.058
2015

Absence of metalloprotease GP63 alters the protein content of leishmania exosomes
PLoS ONE
Hassani, K. and Shio, M.T. and Martel, C. and Faubert, D. and Olivier, M.
DOI: 10.1371/journal.pone.0095007
2014

Immunomodulatory Impact of Leishmania-Induced Macrophage Exosomes: A Comparative Proteomic and Functional Analysis
PLoS Neglected Tropical Diseases
Hassani, K. and Olivier, M.
DOI: 10.1371/journal.pntd.0002185
2013

Host cell signalling and leishmania mechanisms of evasion
Journal of Tropical Medicine
Shio, M.T. and Hassani, K. and Isnard, A. and Ralph, B. and Contreras, I. and Gomez, M.A. and Abu-Dayyeh, I. and Olivier, M.
DOI: 10.1155/2012/819512
2012

Leishmania virulence factors: Focus on the metalloprotease GP63
Microbes and Infection
Olivier, M. and Atayde, V.D. and Isnard, A. and Hassani, K. and Shio, M.T.
DOI: 10.1016/j.micinf.2012.05.014
2012

Temperature-induced protein secretion by leishmania mexicana modulates macrophage signalling and function
PLoS ONE
Hassani, K. and Antoniak, E. and Jardim, A. and Olivier, M.
DOI: 10.1371/journal.pone.0018724
2011

Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions
Infection and Immunity
Abu-Dayyeh, I. and Hassani, K. and Westra, E.R. and Mottram, J.C. and Olivier, M.
DOI: 10.1128/IAI.00812-09
2010

Editorial: Protease inhibitors as prophylaxis against leishmaniasis: New hope from the major surface protease gp63
Future Medicinal Chemistry
Olivier, M. and Hassani, K.
DOI: 10.4155/fmc.10.17
2010

Searching for virulence factors in the non-pathogenic parasite to humans Leishmania tarentolae
Parasitology
Azizi, H. and Hassani, K. and Taslimi, Y. and Najafabadi, H.S. and Papadopoulou, B. and Rafati, S.
DOI: 10.1017/S0031182009005873
2009

Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1)
Immunology
Blanchette, J. and Abu-Dayyeh, I. and Hassani, K. and Whitcombe, L. and Olivier, M.
DOI: 10.1111/j.1365-2567.2008.02929.x
2009

On the optimality of the genetic code, with the consideration of coevolution theory by comparison of prominent cost measure matrices
Journal of Theoretical Biology
Goodarzi, H. and Najafabadi, H.S. and Hassani, K. and Nejad, H.A. and Torabi, N.
DOI: 10.1016/j.jtbi.2005.01.012
2005

Research

Evaluation of the BC Pediatric Early Warning System
Pediatric Early warning systems (PEWS) are used to identify early signs of deterioration in pediatric patients and escalate care to prevent them. They also support health care providers, especially in regional and community hospitals, in assessing pediatric patients as their normal vital signs vary by age and are capable of physiologic compensation.

After roll-out of PEWS in emergency departments across many sites in BC, we’re studying its effectiveness and impact by surveying direct care providers, and analyzing health administrative data and health records. Our aim is to understand the strengths and limitations of PEWS and work to improve the system to better support clinicians in providing care.

Outside Play and Risky Play in the Early Years
Playing outdoors and taking risks are a necessary part of healthy play and research shows that they are critical for healthy child development. However, most children today do not meet the recommended guidelines for physical activity. In close partnership with Dr. Mariana Brussoni’s team and under the platform of Appetite to Play, we are launching online webinars on outside play and risky play for early years providers. Our aim is to understand if and how these workshops can improve the knowledge and capacity of early years providers in offering risky play and outside play opportunities in their childcare settings.