Publications

Feasibility and safety of a 6-month exercise program to increase bone and muscle strength in children with juvenile idiopathic arthritis
Pediatric Rheumatology
DOI: 10.1186/s12969-018-0283-4
12/2018

“I just want to get better”: experiences of children and youth with juvenile idiopathic arthritis in a home-based exercise intervention
Pediatric Rheumatology
DOI: 10.1186/s12969-018-0273-6
12/2018

Does competitive swimming affect lung growth?
Physiological Reports
DOI: 10.14814/phy2.13816
08/2018

Trajectories of pain severity in juvenile idiopathic arthritis
PAIN
Natalie J. Shiff and Susan Tupper and Kiem Oen and Jaime Guzman and Hyun Lim and Chel Hee Lee and Rhonda Bryce and Adam M. Huber and Gilles Boire and Paul Dancey and Brian Feldman and Ronald Laxer and Paivi Miettunen and Heinrike Schmeling and Karen Watanabe Duffy and Deborah M. Levy and Stuart Turvey and Roxana Bolaria and Alessandra Bruns and David A. Cabral and Sarah Campillo and Gaëlle Chédeville and Debbie Ehrmann Feldman and Elie Haddad and Kristin Houghton and Nicole Johnson and Roman Jurencak and Bianca Lang and Maggie Larche and Kimberly Morishita and Suzanne Ramsey and Johannes Roth and Rayfel Schneider and Rosie Scuccimarri and Lynn Spiegel and Elizabeth Stringer and Shirley M. Tse and Rae Yeung and Ciarán M. Duffy and Lori B. Tucker
DOI: 10.1097/j.pain.0000000000001064
01/2018

Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
Pediatric Rheumatology
Jaime Guzman and Tristan Kerr and Leanne M. Ward and Jinhui Ma and Kiem Oen and Alan M. Rosenberg and Brian M. Feldman and Gilles Boire and Kristin Houghton and Paul Dancey and Rosie Scuccimarri and Alessandra Bruns and Adam M. Huber and Karen Watanabe Duffy and Natalie J. Shiff and Roberta A. Berard and Deborah M. Levy and Elizabeth Stringer and Kimberly Morishita and Nicole Johnson and David A. Cabral and Maggie Larché and Ross E. Petty and Ronald M. Laxer and Earl Silverman and Paivi Miettunen and Anne-Laure Chetaille and Elie Haddad and Lynn Spiegel and Stuart E. Turvey and Heinrike Schmeling and Bianca Lang and Janet Ellsworth and Suzanne E. Ramsey and Johannes Roth and Sarah Campillo and Susanne Benseler and Gaëlle Chédeville and Rayfel Schneider and Shirley M. L. Tse and Roxana Bolaria and Katherine Gross and Debbie Feldman and Bonnie Cameron and Roman Jurencak and Jean Dorval and Claire LeBlanc and Claire St. Cyr and Michele Gibbon and Rae S. M. Yeung and Ciarán M. Duffy and Lo
DOI: 10.1186/s12969-017-0196-7
08/2017

Does Competitive Swimming During Puberty Affect Lung Development?
Medicine & Science in Sports & Exercise
Joshua M. Bovard and Joseph F. Welch and Kristin M. Houghton and Donald C. McKenzie and James E. Potts and A. William Sheel
DOI: 10.1249/01.mss.0000516854.42976.41
05/2017

The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus
Clinical Immunology
Robert J. Ragotte and Anita Dhanrajani and Julian Pleydell-Pearce and Kate L. Del Bel and Maja Tarailo-Graovac and Clara van Karnebeek and Jefferson Terry and Christof Senger and Margaret L. McKinnon and Michael Seear and Julie S. Prendiville and Lori B. Tucker and Kristin Houghton and David A. Cabral and Jaime Guzman and Ross E. Petty and Kelly L. Brown and Jenny Tekano and John Wu and Kimberly A. Morishita and Stuart E. Turvey
DOI: 10.1016/j.clim.2016.12.006
02/2017

Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy
Arthritis Research & Therapy
Arndt H. Brachat and for the Pediatric Rheumatology International Trials Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Alexei A. Grom and Nico Wulffraat and Hermine I. Brunner and Pierre Quartier and Riva Brik and Liza McCann and Huri Ozdogan and Lidia Rutkowska-Sak and Rayfel Schneider and Valeria Gerloni and Liora Harel and Maria Terreri and Kristin Houghton and Rik Joos and Daniel Kingsbury and Jorge M. Lopez-Benitez and Stephan Bek and Martin Schumacher and Marie-Anne Valentin and Hermann Gram and Ken Abrams and Alberto Martini and Daniel J. Lovell and Nanguneri R. Nirmala and Nicolino Ruperto
DOI: 10.1186/s13075-016-1212-x
01/2017

Health-Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis
Arthritis Care & Research
Kiem Oen and Jaime Guzman and Brenden Dufault and Lori B. Tucker and Natalie J. Shiff and Karen Watanabe Duffy and Jennifer J. Y. Lee and Brian M. Feldman and Roberta A. Berard and Paul Dancey and Adam M. Huber and Rosie Scuccimarri and David A. Cabral and Kimberly A. Morishita and Suzanne E. Ramsey and Alan M. Rosenberg and Gilles Boire and Susanne M. Benseler and Bianca Lang and Kristin Houghton and Paivi M. Miettunen and Gaëlle Chédeville and Deborah M. Levy and Alessandra Bruns and Heinrike Schmeling and Elie Haddad and Rae S. M. Yeung and Ciarán M. Duffy and the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators
DOI: 10.1002/acr.23236
2017

Management of Juvenile Idiopathic Arthritis 2015: A Position Statement from the Pediatric Committee of the Canadian Rheumatology Association
The Journal of Rheumatology
T. CELLUCCI and J. GUZMAN and R. E. PETTY and M. BATTHISH and S. M. BENSELER and J. E. ELLSWORTH and K. M. HOUGHTON and C. M. A. LeBLANC and A. M. HUBER and N. LUCA and H. SCHMELING and N. J. SHIFF and G. S. SOON and S. M. L. TSE and On behalf of the Pediatric Committee of the Canadian Rheumatology Association
DOI: 10.3899/jrheum.160074
10/2016

Northern Highlights: Exercise is Medicine – Keeping Kids with Arthritis Active
Canadian Rheumatology Association Journal
10/2016

‘It might hurt, but you have to push through the pain’
Journal of Child Health Care
Douglas L Race and Joanie Sims-Gould and Lori B Tucker and Ciaran M Duffy and Debbie Ehrmann Feldman and Michele Gibbon and Kristin M Houghton and Jennifer N Stinson and Elizabeth Stringer and Shirley ML Tse and Heather A McKay
DOI: 10.1177/1367493516632616
07/2016

Development of System-level Performance Measures for Evaluation of Models of Care for Inflammatory Arthritis in Canada
The Journal of Rheumatology
C. E. H. Barber and D. A. Marshall and D. P. Mosher and P. Akhavan and L. Tucker and K. Houghton and M. Batthish and D. M. Levy and H. Schmeling and J. Ellsworth and H. Tibollo and S. Grant and D. Khodyakov and D. Lacaille and V. Ahluwalia and H. Averns and C. Barnabe and C. Bombardier and S. J. Bartlett and S. Bernatsky and J. Burt and D. Feldman and D. D. Gladman and B. Greene and B. Haraoui and N. Haroon and C. Hofstetter and A. M. Huber and S. Keeling and B. Lang and S. A. Le Clercq and T. Lupton and R. Mandhane and K. Morishita and A. Papachristos and P. Patrick and D. Richards and D. Robinson and N. J. Shiff and T. Taylor and R. Taylor-Gjevre and G. T. D. Thomson and C. Thorne and K. Toupin-April and P. Tugwell and M. D. Westby and J. Widdifield and L. Woodhouse and M. Zummer and The Arthritis Alliance of Canada Performance Measurement Development Panel
DOI: 10.3899/jrheum.150839
01/2016

Noninflammatory Musculoskeletal Pain
Textbook of Pediatric Rheumatology
Claire LeBlanc and Kristin Houghton
DOI: 10.1016/b978-0-323-24145-8.00051-x
2016

Proposal for a Candidate Core Set of Fitness and Strength Tests for Patients with Childhood or Adult Idiopathic Inflammatory Myopathies
The Journal of Rheumatology
Djamilla K.D. van der Stap and Lisa G. Rider and Helene Alexanderson and Adam M. Huber and Bruno Gualano and Patrick Gordon and Janjaap van der Net and Pernille Mathiesen and Liam G. Johnson and Floranne C. Ernste and Brian M. Feldman and Kristin M. Houghton and Davinder Singh-Grewal and Abraham Garcia Kutzbach and Li Alemo Munters and Tim Takken and on behalf of the International Myositis Assessment and Clinical Studies Group
DOI: 10.3899/jrheum.150270
11/2015

Participation in Juvenile Idiopathic Arthritis
The Journal of Rheumatology
K. M. HOUGHTON
DOI: 10.3899/jrheum.150438
09/2015

Incident Vertebral Fractures and Risk Factors in the First Three Years Following Glucocorticoid Initiation Among Pediatric Patients With Rheumatic Disorders
Journal of Bone and Mineral Research
Claire MA LeBlanc and Jinhui Ma and Monica Taljaard and Johannes Roth and Rosie Scuccimarri and Paivi Miettunen and Bianca Lang and Adam M Huber and Kristin Houghton and Jacob L Jaremko and Josephine Ho and Nazih Shenouda and Mary Ann Matzinger and Brian Lentle and Robert Stein and Anne Marie Sbrocchi and Kiem Oen and Celia Rodd and Roman Jurencak and Elizabeth A Cummings and Robert Couch and David A Cabral and Stephanie Atkinson and Nathalie Alos and Frank Rauch and Kerry Siminoski and Leanne M Ward and the Canadian STeroid-Associated Osteoporosis in the Pediatric Population (STOPP) Consortium
DOI: 10.1002/jbmr.2511
05/2015

The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort
Annals of the Rheumatic Diseases
Jaime Guzman and Kiem Oen and Adam M Huber and Karen Watanabe Duffy and Gilles Boire and Natalie Shiff and Roberta A Berard and Deborah M Levy and Elizabeth Stringer and Rosie Scuccimarri and Kimberly Morishita and Nicole Johnson and David A Cabral and Alan M Rosenberg and Maggie Larché and Paul Dancey and Ross E Petty and Ronald M Laxer and Earl Silverman and Paivi Miettunen and Anne-Laure Chetaille and Elie Haddad and Kristin Houghton and Lynn Spiegel and Stuart E Turvey and Heinrike Schmeling and Bianca Lang and Janet Ellsworth and Suzanne E Ramsey and Alessandra Bruns and Johannes Roth and Sarah Campillo and Susanne Benseler and Gaëlle Chédeville and Rayfel Schneider and Shirley M L Tse and Roxana Bolaria and Katherine Gross and Brian Feldman and Debbie Feldman and Bonnie Cameron and Roman Jurencak and Jean Dorval and Claire LeBlanc and Claire St. Cyr and Michele Gibbon and Rae S M Yeung and Ciarán M Duffy and Lori B Tucker
DOI: 10.1136/annrheumdis-2014-207164
05/2015

The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort
Annals of the Rheumatic Diseases
Jaime Guzman and Kiem Oen and Lori B Tucker and Adam M Huber and Natalie Shiff and Gilles Boire and Rosie Scuccimarri and Roberta Berard and Shirley M L Tse and Kimberly Morishita and Elizabeth Stringer and Nicole Johnson and Deborah M Levy and Karen Watanabe Duffy and David A Cabral and Alan M Rosenberg and Maggie Larché and Paul Dancey and Ross E Petty and Ronald M Laxer and Earl Silverman and Paivi Miettunen and Anne-Laure Chetaille and Elie Haddad and Kristin Houghton and Lynn Spiegel and Stuart E Turvey and Heinrike Schmeling and Bianca Lang and Janet Ellsworth and Suzanne Ramsey and Alessandra Bruns and Sarah Campillo and Susanne Benseler and Gaëlle Chédeville and Rayfel Schneider and Rae Yeung and Ciarán M Duffy
DOI: 10.1136/annrheumdis-2014-205372
05/2014

Childhood regional conditions
Oxford Textbook of Rheumatology
Kristin Houghton
DOI: 10.1093/med/9780199642489.003.0158
10/2013

Evaluation of Static and Dynamic Postural Balance in Children With Juvenile Idiopathic Arthritis
Pediatric Physical Therapy
Kristin Michelle Houghton and Jaime Guzman
DOI: 10.1097/pep.0b013e31828a2978
2013

Bodychecking in youth ice hockey
Paediatrics & Child Health
Kristin M Houghton and Carolyn A Emery
DOI: 10.1093/pch/17.9.509
11/2012

Physical Activity, Physical Fitness, and Exercise Therapy in Children with Juvenile Idiopathic Arthritis
The Physician and Sportsmedicine
Kristin Houghton
DOI: 10.3810/psm.2012.09.1979
09/2012

Exercise-induced intrapulmonary arteriovenous shunt in healthy women
Respiratory Physiology & Neurobiology
Jill M. Kennedy and Glen E. Foster and Michael S. Koehle and James E. Potts and George G.S. Sandor and M. Terri Potts and Kristin M. Houghton and William R. Henderson and A. William Sheel
DOI: 10.1016/j.resp.2012.01.004
04/2012

Corticosteroid related changes in body mass index in children and adolescents with rheumatic diseases
Pediatric Rheumatology
Natalie Shiff and Rollin Brant and David A Cabral and Jaime Guzman and Peter B Dent and Janet E Ellsworth and Kristin M Houghton and Adam Huber and Roman Jurencak and Bianca A Lang and Maggie Larche and Claire MA LeBlanc and Paivi M Miettunen and Kiem G Oen and Johannes Roth and Claire Saint-Cyr and Rosie Scuccimarri and Leanne M Ward and Canadian STOPP Consortium
DOI: 10.1186/1546-0096-10-s1-a11
2012

Incident vertebral fractures 12 months following glucocorticoid initiation in children with rheumatic disorders
Pediatric Rheumatology
Bianca A Lang and Celia Rodd and Timothy Ramsay and David A Cabral and Peter B Dent and Janet E Ellsworth and Kristin M Houghton and Adam Huber and Roman Jurencak and Maggie Larché and Claire MA LeBlanc and Brian Lentle and MaryAnn Matzinger and Paivi M Miettunen and Kiem Oen and Johannes Roth and Claire Saint-Cyr and Rosie Scuccimarri and Nazih Shenouda and Leanne M Ward and Canadian STOPP Consortium
DOI: 10.1186/1546-0096-10-s1-a75
2012

Glucocorticoid-related changes in body mass index among children and adolescents with rheumatic diseases
Arthritis Care & Research
Natalie J. Shiff and Rollin Brant and Jaime Guzman and David A. Cabral and Adam M. Huber and Paivi M. Miettunen and Johannes Roth and Rosie Scuccimarri and Nathalie Alos and Stephanie A. Atkinson and Jean Paul Collet and Robert Couch and Elizabeth A. Cummings and Peter B. Dent and Janet Ellsworth and John Hay and Kristin Houghton and Roman Jurencak and Bianca Lang and Maggie Larche and Claire LeBlanc and Celia Rodd and Claire Saint-Cyr and Robert Stein and David Stephure and Shayne Taback and Frank Rauch and Leanne M. Ward and and The Canadian Steroid-associated Osteoporosis in the Pediatric Population Consortium
DOI: 10.1002/acr.21785
2012

NONINFLAMMATORY MUSCULOSKELETAL PAIN CONDITIONS
Textbook of Pediatric Rheumatology
Claire LeBlanc and Kristin Houghton
DOI: 10.1016/b978-1-4160-6581-4.10047-0
2011

Incident vertebral fractures among children with rheumatic disorders 12 months after glucocorticoid initiation: A national observational study
Arthritis Care & Research
Celia Rodd and Bianca Lang and Timothy Ramsay and Nathalie Alos and Adam M. Huber and David A. Cabral and Rosie Scuccimarri and Paivi M. Miettunen and Johannes Roth and Stephanie A. Atkinson and Robert Couch and Elizabeth A. Cummings and Peter B. Dent and Janet Ellsworth and John Hay and Kristin Houghton and Roman Jurencak and Maggie Larché and Claire LeBlanc and Kiem Oen and Claire Saint-Cyr and Robert Stein and David Stephure and Shayne Taback and Brian Lentle and Maryann Matzinger and Nazih Shenouda and David Moher and Frank Rauch and Kerry Siminoski and Leanne M. Ward and Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) Consortium
DOI: 10.1002/acr.20589
2011

Childhood Osseous Sarcoidosis Presenting With Headache and Lytic Skull Lesions
JCR: Journal of Clinical Rheumatology
Jubran Theeb Alqanatish and Kristin M. Houghton and Robyn A. Cairns
DOI: 10.1097/rhu.0b013e31823b15ca
2011

Infrapatellar bursitis in children with juvenile idiopathic arthritis: a case series
Clinical Rheumatology
Jubran T. Alqanatish and Ross E. Petty and Kristin M. Houghton and Jaime Guzman and Lori B. Tucker and David A. Cabral and Robyn A. Cairns
DOI: 10.1007/s10067-010-1620-2
11/2010

Rituximab Treatment in a Child with Rosai-Dorfman Disease and Systemic Lupus Erythematosus
The Journal of Rheumatology
J. T. ALQANATISH and K. HOUGHTON and M. BOND and C. SENGER and L. B. TUCKER
DOI: 10.3899/jrheum.091275
08/2010

Joint Communique: My Paralympics Experience
Canadian Rheumatology Association Journal
08/2010

Comparing Aerobic and Anaerobic Power during Upper and Lower Body Exercise in Pediatric Subjects
Medicine & Science in Sports & Exercise
James E. Potts and D. Kathryn Duff and Kristin M. Houghton and Astrid M. De Souza and Bonita J. Sawatzky and William A. Sheel
DOI: 10.1249/01.mss.0000386078.63883.8d
05/2010

Physical Activity Recommendations for Children With Specific Chronic Health Conditions: Juvenile Idiopathic Arthritis, Hemophilia, Asthma, and Cystic Fibrosis
Clinical Journal of Sport Medicine
John F Philpott and Kristin Houghton and Anthony Luke
DOI: 10.1097/jsm.0b013e3181d2eddd
05/2010

Physical activity recommendations for children with specific chronic health conditions: Juvenile idiopathic arthritis, hemophilia, asthma and cystic fibrosis
Paediatrics & Child Health
J Philpott and K Houghton and A Luke
DOI: 10.1093/pch/15.4.213
04/2010

Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort
Arthritis Care & Research
Kiem Oen and Ciarán M. Duffy and Shirley M. L. Tse and Suzanne Ramsey and Janet Ellsworth and Gaëlle Chédeville and Anne-Laure Chetaille and Claire Saint-Cyr and David A. Cabral and Lynn R. Spiegel and Rayfel Schneider and Bianca Lang and Adam M. Huber and Paul Dancey and Earl Silverman and Alan M. Rosenberg and Bonnie Cameron and Nicole Johnson and Jean Dorval and Rosie Scuccimarri and Sarah Campillo and Ross E. Petty and Karen N. Watanabe Duffy and Gilles Boire and Elie Haddad and Kristin Houghton and Ronald Laxer and Stuart E. Turvey and Paivi Miettunen and Katherine Gross and Jaime Guzman and Susanne Benseler and Brian M. Feldman and Victor Espinosa and Rae S. M. Yeung and Lori Tucker
DOI: 10.1002/acr.20044
04/2010

Review for the generalist: evaluation of low back pain in children and adolescents
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-8-28
2010

Non-traumatic causes of musculoskeletal pain
Care of the Young Athlete, 2nd edition
2010

Cutaneous Polyarteritis Nodosa in Childhood: A Case Report and Review of the Literature
Arthritis
Nina-Karen Bansal and Kristin Michelle Houghton
DOI: 10.1155/2010/687547
2010

Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: Results of a Canadian multicenter, prospective inception cohort study
Arthritis & Rheumatism
Kiem Oen and Lori Tucker and Adam M. Huber and Paivi Miettunen and Rosie Scuccimarri and Sarah Campillo and David A. Cabral and Brian M. Feldman and Shirley Tse and Gaëlle Chédeville and Lynn Spiegel and Rayfel Schneider and Bianca Lang and Janet Ellsworth and Suzanne Ramsey and Paul Dancey and Earl Silverman and Anne-Laure Chetaille and Bonnie Cameron and Nicole Johnson and Jean Dorval and Ross E. Petty and Karen Watanabe Duffy and Gilles Boire and Elie Haddad and Kristin Houghton and Claire Saint-Cyr and Stuart E. Turvey and Susanne Benseler and Mary Cheang and Rae S. M. Yeung and Ciarán M. Duffy
DOI: 10.1002/art.24539
08/2009

Access to Pediatric Rheumatology Subspecialty Care in British Columbia, Canada
The Journal of Rheumatology
N. J. SHIFF and R. ABDWANI and D. A. CABRAL and K. M. HOUGHTON and P. N. MALLESON and R. E. PETTY and V. M. ESPINOSA and L. B. TUCKER
DOI: 10.3899/jrheum.080514
02/2009

Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus
Pediatric Rheumatology
Sirirat Charuvanij and Kristin M Houghton
DOI: 10.1186/1546-0096-7-19
2009

Review for the generalist: evaluation of pediatric hip pain
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-7-10
2009

Baseline Fitness Measures In A Cohort Of Obese Children
Medicine & Science in Sports & Exercise
James E. Potts and Astrid M. De Souza and Kristin M. Houghton and Shubhayan Sanatani and Walter J. Duncan and George G.S. Sandor
DOI: 10.1249/01.mss.0000322969.33832.31
05/2008

Development Of A Hospital-Based Exercise Prescription Clinic For Obese Children
Medicine & Science in Sports & Exercise
Astrid M. De Souza and Kristin M. Houghton and Shubhayan Sanatani and Walter J. Duncan and George G.S. Sandor and James E. Potts
DOI: 10.1249/01.mss.0000322970.10962.f9
05/2008

Fitness, fatigue, disease activity, and quality of life in pediatric lupus
Arthritis & Rheumatism
Kristin M. Houghton and Lori B. Tucker and James E. Potts and Donald C. Mckenzie
DOI: 10.1002/art.23534
2008

Role of activity in health and its effect on morbidity and mortality in chronic rheumatic diseases of childhood
Occupational and Physical Therapy for Children with Rheumatic Diseases: A Clinical Handbook
2008

Aerobic and anaerobic capacity in Juvenile Idiopathic Arthritis: evaluation of the cardiorespiratory response
The Internet Journal of Rheumatology
DOI: 10.5580/201f
2008

An adolescent with both Wegener's Granulomatosis and chronic blastomycosis
Pediatric Rheumatology
Reem Abdwani and Kristin Houghton and Simon Dobson and Maureen O' Sullivan and Peter Malleson
DOI: 10.1186/1546-0096-6-13
2008

Review for the generalist: evaluation of pediatric foot and ankle pain
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-6-6
2008

Review for the generalist: evaluation of anterior knee pain
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-5-8
2007

Old challenges and new directions in pediatric rheumatology
Journal of Rheumatology
PubMed: 16395765
01/2006

Systemic lupus erythematosus in the pediatric North American Native population of British Columbia
Journal of Rheumatology
PubMed: 16395763
01/2006

Primary Sjogren’s syndrome in dizygotic adolescent twins: one case presentation with lymphocytic interstitial pneumonia
Journal of Rheumatology
PubMed: 16078341
08/2005

Primary Sjogren’s syndrome in children and adolescents: Are current diagnostic criteria valid?
Journal of Rheumatology
2005

Clinical trial of the sensitivity to tuberculin in children referred for evaluation of Kawasaki disease
Pediatric Rheumatology Online Journal
02/2004

Research

Aerobic and anaerobic exercise capacity in Juvenile Idiopathic Arthritis
Children with juvenile idiopathic arthritis (JIA) have lower physical fitness and lower peak oxygen consumption (VO2 peak) compared to healthy children. Suboptimal VO2 peak may be due to central limitations, characterized by suboptimal heart rate response, cardiac output (CO) or oxygen saturation; or peripheral limitations, characterized by high mixed venous oxygen content (low A-VO2).

In order to examine the cardiorespiratory response during aerobic exercise and the anaerobic to aerobic ratio (metabolic index), patients with JIA and age and sex matched controls are undergoing maximal aerobic and anaerobic exercise tests on a cycle ergometer.

During aerobic exercise we measure CO (litres/minute) with Doppler echocardiography. Arterial – mixed venous oxygen index (A-VO2) and systemic vascular resistance (SVR) are calculated. We hypothesize children with JIA will have lower VO2 peak and lower anaerobic fitness (peak power and total work) than their healthy age matched peers and that children with JIA will have a different cardiorespiratory response during maximal aerobic exercise tests compared to healthy age matched peers.

Children with JIA will have less efficient muscle oxygen utilization during maximal exercise, manifest by lower arterial – venous oxygen difference (A-VO2) (corresponding to higher mixed venous oxygen difference) at a given CO and higher systemic vascular resistance (SVR). We believe better understanding of the cardiorespiratory response during exercise will allow us to more effectively prescribe exercise in children with JIA.

Evaluation of dynamic postural balance using the Biodex Balance System® in children with Juvenile Idiopathic Arthritis
Children and adults with musculoskeletal lower limb injuries are known to lose postural balance. Balance training is now accepted by sports medicine physicians as a standard component of rehabilitation. Adults with arthritis are known to lose balance. It would seem reasonable, although it is not known, that children with arthritis affecting their lower limbs also lose balance.

In this pilot study we aim to evaluate and describe postural balance in a cohort of children with JIA and children without musculoskeletal disease or injury. This pilot will provide the framework for a randomized controlled trial to evaluate the role of balance training in rehabilitation of children with arthritis.

The pilot data will be sufficient to address the hypotheses that children with JIA have poor static and dynamic balance compared to healthy children and that lower extremity strength is positively correlated with static and dynamic balance.

The primary hypothesis of the ensuing intervention trial will be that children with JIA can improve their balance with postural balance training. We believe that balance training and assessment of children with JIA will allow counselling for increased and safe participation in physical activity, decrease the risks of injury and disability, and ultimately improve the quality of life of children with JIA for both the short and long term.

Balance training might also be valuable for children with other illnesses that cause interrupted optimal physical participation.

Honours & Awards

Principal applicant Kathryn Duff PhD. Co-applicants: James E Potts PhD, William Sheel PhD, Bonnie Sawatzky PhD, Astrid DeSouza MSc. Clinical Investigator Program; Royal College of Physicians and Surgeons Fellowship Program. University of British Columbia. Funding for July 2005 to January 2007. Project title: Aerobic capacity in juvenile idiopathic arthritis: central versus peripheral limitations.

Balance in children with Juvenile Idiopathic Arthritis. Equipment grant from the Abercrombie Foundation to purchase the Biodex Balance System® ($22,148.70).

Comparing aerobic and anaerobic power during upper and lower body exercise in pediatric subjects. Pediatric Exercise Working Group. Grant from College-Wide Fund for Scholarly Activity, Douglas College ($3000.00)

Research Group Members

Felice Mizan, Research Coordinator
Angelyne Rivera, Research Manager , Research Manager