Publications

Trajectories of pain severity in juvenile idiopathic arthritis results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort
PAIN
Natalie J. Shiff, Susan Tupper, Kiem Oen, Jaime Guzman, Hyun Lim, Chel Hee Lee, Rhonda Bryce, Adam M. Huber, Gilles Boire, Paul Dancey, Brian Feldman, Ronald Laxer, Paivi Miettunen, Heinrike Schmeling, Karen Watanabe Duffy, Deborah M. Levy, Stuart Turvey, Roxana Bolaria, Alessandra Bruns, David A. Cabral, Sarah Campillo, Gaëlle Chédeville, Debbie Ehrmann Feldman, Elie Haddad, Kristin Houghton, Nicole Johnson, Roman Jurencak, Bianca Lang, Maggie Larche, Kimberly Morishita, Suzanne Ramsey, Johannes Roth, Rayfel Schneider, Rosie Scuccimarri, Lynn Spiegel, Elizabeth Stringer, Shirley M. Tse, Rae Yeung, Ciarán M. Duffy, Lori B. Tucker
DOI: 10.1097/j.pain.0000000000001064
01/2018

Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
Pediatric Rheumatology
Jaime Guzman, Tristan Kerr, Leanne M. Ward, Jinhui Ma, Kiem Oen, Alan M. Rosenberg, Brian M. Feldman, Gilles Boire, Kristin Houghton, Paul Dancey, Rosie Scuccimarri, Alessandra Bruns, Adam M. Huber, Karen Watanabe Duffy, Natalie J. Shiff, Roberta A. Berard, Deborah M. Levy, Elizabeth Stringer, Kimberly Morishita, Nicole Johnson, David A. Cabral, Maggie Larché, Ross E. Petty, Ronald M. Laxer, Earl Silverman, Paivi Miettunen, Anne-Laure Chetaille, Elie Haddad, Lynn Spiegel, Stuart E. Turvey, Heinrike Schmeling, Bianca Lang, Janet Ellsworth, Suzanne E. Ramsey, Johannes Roth, Sarah Campillo, Susanne Benseler, Gaëlle Chédeville, Rayfel Schneider, Shirley M. L. Tse, Roxana Bolaria, Katherine Gross, Debbie Feldman, Bonnie Cameron, Roman Jurencak, Jean Dorval, Claire LeBlanc, Claire St. Cyr, Michele Gibbon, Rae S. M. Yeung, Ciarán M. Duffy, Lori B. Tucker
DOI: 10.1186/s12969-017-0196-7
08/2017

Does Competitive Swimming During Puberty Affect Lung Development?128 May 31 10
Medicine & Science in Sports & Exercise
Joshua M. Bovard, Joseph F. Welch, Kristin M. Houghton, Donald C. McKenzie, James E. Potts, A. William Sheel
DOI: 10.1249/01.mss.0000516854.42976.41
05/2017

The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus
Clinical Immunology
Robert J. Ragotte, Anita Dhanrajani, Julian Pleydell-Pearce, Kate L. Del Bel, Maja Tarailo-Graovac, Clara van Karnebeek, Jefferson Terry, Christof Senger, Margaret L. McKinnon, Michael Seear, Julie S. Prendiville, Lori B. Tucker, Kristin Houghton, David A. Cabral, Jaime Guzman, Ross E. Petty, Kelly L. Brown, Jenny Tekano, John Wu, Kimberly A. Morishita, Stuart E. Turvey
DOI: 10.1016/j.clim.2016.12.006
02/2017

Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy
Arthritis Research & Therapy
Arndt H. Brachat, for the Pediatric Rheumatology International Trials Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG), Alexei A. Grom, Nico Wulffraat, Hermine I. Brunner, Pierre Quartier, Riva Brik, Liza McCann, Huri Ozdogan, Lidia Rutkowska-Sak, Rayfel Schneider, Valeria Gerloni, Liora Harel, Maria Terreri, Kristin Houghton, Rik Joos, Daniel Kingsbury, Jorge M. Lopez-Benitez, Stephan Bek, Martin Schumacher, Marie-Anne Valentin, Hermann Gram, Ken Abrams, Alberto Martini, Daniel J. Lovell, Nanguneri R. Nirmala, Nicolino Ruperto
DOI: 10.1186/s13075-016-1212-x
01/2017

Health-Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis
Arthritis Care & Research
Kiem Oen, Jaime Guzman, Brenden Dufault, Lori B. Tucker, Natalie J. Shiff, Karen Watanabe Duffy, Jennifer J. Y. Lee, Brian M. Feldman, Roberta A. Berard, Paul Dancey, Adam M. Huber, Rosie Scuccimarri, David A. Cabral, Kimberly A. Morishita, Suzanne E. Ramsey, Alan M. Rosenberg, Gilles Boire, Susanne M. Benseler, Bianca Lang, Kristin Houghton, Paivi M. Miettunen, Gaëlle Chédeville, Deborah M. Levy, Alessandra Bruns, Heinrike Schmeling, Elie Haddad, Rae S. M. Yeung, Ciarán M. Duffy, the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators
DOI: 10.1002/acr.23236
2017

Northern Highlights: Exercise is Medicine – Keeping Kids with Arthritis ActiveNon-Refereed
Canadian Rheumatology Association Journal
10/2016

Management of Juvenile Idiopathic Arthritis 2015: A Position Statement from the Pediatric Committee of the Canadian Rheumatology Association
The Journal of Rheumatology
T. CELLUCCI, J. GUZMAN, R. E. PETTY, M. BATTHISH, S. M. BENSELER, J. E. ELLSWORTH, K. M. HOUGHTON, C. M. A. LeBLANC, A. M. HUBER, N. LUCA, H. SCHMELING, N. J. SHIFF, G. S. SOON, S. M. L. TSE, On behalf of the Pediatric Committee of the Canadian Rheumatology Association
DOI: 10.3899/jrheum.160074
10/2016

‘It might hurt, but you have to push through the pain’Perspectives on physical activity from children with juvenile idiopathic arthritis and their parents
Journal of Child Health Care
Douglas L Race, Joanie Sims-Gould, Lori B Tucker, Ciaran M Duffy, Debbie Ehrmann Feldman, Michele Gibbon, Kristin M Houghton, Jennifer N Stinson, Elizabeth Stringer, Shirley ML Tse, Heather A McKay
DOI: 10.1177/1367493516632616
07/2016

Development of System-level Performance Measures for Evaluation of Models of Care for Inflammatory Arthritis in Canada
The Journal of Rheumatology
C. E. H. Barber, D. A. Marshall, D. P. Mosher, P. Akhavan, L. Tucker, K. Houghton, M. Batthish, D. M. Levy, H. Schmeling, J. Ellsworth, H. Tibollo, S. Grant, D. Khodyakov, D. Lacaille, V. Ahluwalia, H. Averns, C. Barnabe, C. Bombardier, S. J. Bartlett, S. Bernatsky, J. Burt, D. Feldman, D. D. Gladman, B. Greene, B. Haraoui, N. Haroon, C. Hofstetter, A. M. Huber, S. Keeling, B. Lang, S. A. Le Clercq, T. Lupton, R. Mandhane, K. Morishita, A. Papachristos, P. Patrick, D. Richards, D. Robinson, N. J. Shiff, T. Taylor, R. Taylor-Gjevre, G. T. D. Thomson, C. Thorne, K. Toupin-April, P. Tugwell, M. D. Westby, J. Widdifield, L. Woodhouse, M. Zummer, The Arthritis Alliance of Canada Performance Measurement Development Panel
DOI: 10.3899/jrheum.150839
01/2016

Noninflammatory Musculoskeletal Pain
Textbook of Pediatric Rheumatology
Claire LeBlanc, Kristin Houghton
DOI: 10.1016/b978-0-323-24145-8.00051-x
2016

Proposal for a Candidate Core Set of Fitness and Strength Tests for Patients with Childhood or Adult Idiopathic Inflammatory Myopathies
The Journal of Rheumatology
Djamilla K.D. van der Stap, Lisa G. Rider, Helene Alexanderson, Adam M. Huber, Bruno Gualano, Patrick Gordon, Janjaap van der Net, Pernille Mathiesen, Liam G. Johnson, Floranne C. Ernste, Brian M. Feldman, Kristin M. Houghton, Davinder Singh-Grewal, Abraham Garcia Kutzbach, Li Alemo Munters, Tim Takken, on behalf of the International Myositis Assessment and Clinical Studies Group
DOI: 10.3899/jrheum.150270
11/2015

Participation in Juvenile Idiopathic Arthritis
The Journal of Rheumatology
K. M. HOUGHTON
DOI: 10.3899/jrheum.150438
09/2015

Incident Vertebral Fractures and Risk Factors in the First Three Years Following Glucocorticoid Initiation Among Pediatric Patients With Rheumatic DisordersINCIDENT VF IN PEDIATRIC PATIENTS WITH RHEUMATIC DISORDERS
Journal of Bone and Mineral Research
Claire MA LeBlanc, Jinhui Ma, Monica Taljaard, Johannes Roth, Rosie Scuccimarri, Paivi Miettunen, Bianca Lang, Adam M Huber, Kristin Houghton, Jacob L Jaremko, Josephine Ho, Nazih Shenouda, Mary Ann Matzinger, Brian Lentle, Robert Stein, Anne Marie Sbrocchi, Kiem Oen, Celia Rodd, Roman Jurencak, Elizabeth A Cummings, Robert Couch, David A Cabral, Stephanie Atkinson, Nathalie Alos, Frank Rauch, Kerry Siminoski, Leanne M Ward, the Canadian STeroid-Associated Osteoporosis in the Pediatric Population (STOPP) Consortium
DOI: 10.1002/jbmr.2511
05/2015

The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort
Annals of the Rheumatic Diseases
Jaime Guzman, Kiem Oen, Adam M Huber, Karen Watanabe Duffy, Gilles Boire, Natalie Shiff, Roberta A Berard, Deborah M Levy, Elizabeth Stringer, Rosie Scuccimarri, Kimberly Morishita, Nicole Johnson, David A Cabral, Alan M Rosenberg, Maggie Larché, Paul Dancey, Ross E Petty, Ronald M Laxer, Earl Silverman, Paivi Miettunen, Anne-Laure Chetaille, Elie Haddad, Kristin Houghton, Lynn Spiegel, Stuart E Turvey, Heinrike Schmeling, Bianca Lang, Janet Ellsworth, Suzanne E Ramsey, Alessandra Bruns, Johannes Roth, Sarah Campillo, Susanne Benseler, Gaëlle Chédeville, Rayfel Schneider, Shirley M L Tse, Roxana Bolaria, Katherine Gross, Brian Feldman, Debbie Feldman, Bonnie Cameron, Roman Jurencak, Jean Dorval, Claire LeBlanc, Claire St. Cyr, Michele Gibbon, Rae S M Yeung, Ciarán M Duffy, Lori B Tucker
DOI: 10.1136/annrheumdis-2014-207164
05/2015

The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort
Annals of the Rheumatic Diseases
Jaime Guzman, Kiem Oen, Lori B Tucker, Adam M Huber, Natalie Shiff, Gilles Boire, Rosie Scuccimarri, Roberta Berard, Shirley M L Tse, Kimberly Morishita, Elizabeth Stringer, Nicole Johnson, Deborah M Levy, Karen Watanabe Duffy, David A Cabral, Alan M Rosenberg, Maggie Larché, Paul Dancey, Ross E Petty, Ronald M Laxer, Earl Silverman, Paivi Miettunen, Anne-Laure Chetaille, Elie Haddad, Kristin Houghton, Lynn Spiegel, Stuart E Turvey, Heinrike Schmeling, Bianca Lang, Janet Ellsworth, Suzanne Ramsey, Alessandra Bruns, Sarah Campillo, Susanne Benseler, Gaëlle Chédeville, Rayfel Schneider, Rae Yeung, Ciarán M Duffy
DOI: 10.1136/annrheumdis-2014-205372
05/2014

Childhood regional conditions
Oxford Textbook of Rheumatology
Kristin Houghton
DOI: 10.1093/med/9780199642489.003.0158
10/2013

Evaluation of Static and Dynamic Postural Balance in Children With Juvenile Idiopathic Arthritis
Pediatric Physical Therapy
Kristin Michelle Houghton, Jaime Guzman
DOI: 10.1097/pep.0b013e31828a2978
2013

Bodychecking in youth ice hockey
Paediatrics & Child Health
Kristin M Houghton, Carolyn A Emery
DOI: 10.1093/pch/17.9.509
11/2012

Physical Activity, Physical Fitness, and Exercise Therapy in Children with Juvenile Idiopathic Arthritis
The Physician and Sportsmedicine
Kristin Houghton
DOI: 10.3810/psm.2012.09.1979
09/2012

Exercise-induced intrapulmonary arteriovenous shunt in healthy women
Respiratory Physiology & Neurobiology
Jill M. Kennedy, Glen E. Foster, Michael S. Koehle, James E. Potts, George G.S. Sandor, M. Terri Potts, Kristin M. Houghton, William R. Henderson, A. William Sheel
DOI: 10.1016/j.resp.2012.01.004
04/2012

Incident vertebral fractures 12 months following glucocorticoid initiation in children with rheumatic disorders
Pediatric Rheumatology
Bianca A Lang, Celia Rodd, Timothy Ramsay, David A Cabral, Peter B Dent, Janet E Ellsworth, Kristin M Houghton, Adam Huber, Roman Jurencak, Maggie Larché, Claire MA LeBlanc, Brian Lentle, MaryAnn Matzinger, Paivi M Miettunen, Kiem Oen, Johannes Roth, Claire Saint-Cyr, Rosie Scuccimarri, Nazih Shenouda, Leanne M Ward, Canadian STOPP Consortium
DOI: 10.1186/1546-0096-10-s1-a75
2012

Corticosteroid related changes in body mass index in children and adolescents with rheumatic diseases
Pediatric Rheumatology
Natalie Shiff, Rollin Brant, David A Cabral, Jaime Guzman, Peter B Dent, Janet E Ellsworth, Kristin M Houghton, Adam Huber, Roman Jurencak, Bianca A Lang, Maggie Larche, Claire MA LeBlanc, Paivi M Miettunen, Kiem G Oen, Johannes Roth, Claire Saint-Cyr, Rosie Scuccimarri, Leanne M Ward, Canadian STOPP Consortium
DOI: 10.1186/1546-0096-10-s1-a11
2012

Glucocorticoid-related changes in body mass index among children and adolescents with rheumatic diseases
Arthritis Care & Research
Natalie J. Shiff, Rollin Brant, Jaime Guzman, David A. Cabral, Adam M. Huber, Paivi M. Miettunen, Johannes Roth, Rosie Scuccimarri, Nathalie Alos, Stephanie A. Atkinson, Jean Paul Collet, Robert Couch, Elizabeth A. Cummings, Peter B. Dent, Janet Ellsworth, John Hay, Kristin Houghton, Roman Jurencak, Bianca Lang, Maggie Larche, Claire LeBlanc, Celia Rodd, Claire Saint-Cyr, Robert Stein, David Stephure, Shayne Taback, Frank Rauch, Leanne M. Ward, and The Canadian Steroid-associated Osteoporosis in the Pediatric Population Consortium
DOI: 10.1002/acr.21785
2012

NONINFLAMMATORY MUSCULOSKELETAL PAIN CONDITIONS
Textbook of Pediatric Rheumatology
Claire LeBlanc, Kristin Houghton
DOI: 10.1016/b978-1-4160-6581-4.10047-0
2011

Childhood Osseous Sarcoidosis Presenting With Headache and Lytic Skull Lesions
JCR: Journal of Clinical Rheumatology
Jubran Theeb Alqanatish, Kristin M. Houghton, Robyn A. Cairns
DOI: 10.1097/rhu.0b013e31823b15ca
2011

Incident vertebral fractures among children with rheumatic disorders 12 months after glucocorticoid initiation: A national observational study
Arthritis Care & Research
Celia Rodd, Bianca Lang, Timothy Ramsay, Nathalie Alos, Adam M. Huber, David A. Cabral, Rosie Scuccimarri, Paivi M. Miettunen, Johannes Roth, Stephanie A. Atkinson, Robert Couch, Elizabeth A. Cummings, Peter B. Dent, Janet Ellsworth, John Hay, Kristin Houghton, Roman Jurencak, Maggie Larché, Claire LeBlanc, Kiem Oen, Claire Saint-Cyr, Robert Stein, David Stephure, Shayne Taback, Brian Lentle, Maryann Matzinger, Nazih Shenouda, David Moher, Frank Rauch, Kerry Siminoski, Leanne M. Ward, Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) Consortium
DOI: 10.1002/acr.20589
2011

Infrapatellar bursitis in children with juvenile idiopathic arthritis: a case series
Clinical Rheumatology
Jubran T. Alqanatish, Ross E. Petty, Kristin M. Houghton, Jaime Guzman, Lori B. Tucker, David A. Cabral, Robyn A. Cairns
DOI: 10.1007/s10067-010-1620-2
11/2010

Joint Communique: My Paralympics ExperienceNon-Refereed
Canadian Rheumatology Association Journal
08/2010

Rituximab Treatment in a Child with Rosai-Dorfman Disease and Systemic Lupus Erythematosus
The Journal of Rheumatology
J. T. ALQANATISH, K. HOUGHTON, M. BOND, C. SENGER, L. B. TUCKER
DOI: 10.3899/jrheum.091275
08/2010

Comparing Aerobic and Anaerobic Power during Upper and Lower Body Exercise in Pediatric Subjects2690
Medicine & Science in Sports & Exercise
James E. Potts, D. Kathryn Duff, Kristin M. Houghton, Astrid M. De Souza, Bonita J. Sawatzky, William A. Sheel
DOI: 10.1249/01.mss.0000386078.63883.8d
05/2010

Physical Activity Recommendations for Children With Specific Chronic Health Conditions: Juvenile Idiopathic Arthritis, Hemophilia, Asthma, and Cystic Fibrosis
Clinical Journal of Sport Medicine
John F Philpott, Kristin Houghton, Anthony Luke
DOI: 10.1097/jsm.0b013e3181d2eddd
05/2010

Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort
Arthritis Care & Research
Kiem Oen, Ciarán M. Duffy, Shirley M. L. Tse, Suzanne Ramsey, Janet Ellsworth, Gaëlle Chédeville, Anne-Laure Chetaille, Claire Saint-Cyr, David A. Cabral, Lynn R. Spiegel, Rayfel Schneider, Bianca Lang, Adam M. Huber, Paul Dancey, Earl Silverman, Alan M. Rosenberg, Bonnie Cameron, Nicole Johnson, Jean Dorval, Rosie Scuccimarri, Sarah Campillo, Ross E. Petty, Karen N. Watanabe Duffy, Gilles Boire, Elie Haddad, Kristin Houghton, Ronald Laxer, Stuart E. Turvey, Paivi Miettunen, Katherine Gross, Jaime Guzman, Susanne Benseler, Brian M. Feldman, Victor Espinosa, Rae S. M. Yeung, Lori Tucker
DOI: 10.1002/acr.20044
04/2010

Physical activity recommendations for children with specific chronic health conditions: Juvenile idiopathic arthritis, hemophilia, asthma and cystic fibrosis
Paediatrics & Child Health
J Philpott, K Houghton, A Luke
DOI: 10.1093/pch/15.4.213
04/2010

Cutaneous Polyarteritis Nodosa in Childhood: A Case Report and Review of the Literature
Arthritis
Nina-Karen Bansal, Kristin Michelle Houghton
DOI: 10.1155/2010/687547
2010

Non-traumatic causes of musculoskeletal pain
Care of the Young Athlete, 2nd edition
2010

Review for the generalist: evaluation of low back pain in children and adolescents
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-8-28
2010

Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: Results of a Canadian multicenter, prospective inception cohort study
Arthritis & Rheumatism
Kiem Oen, Lori Tucker, Adam M. Huber, Paivi Miettunen, Rosie Scuccimarri, Sarah Campillo, David A. Cabral, Brian M. Feldman, Shirley Tse, Gaëlle Chédeville, Lynn Spiegel, Rayfel Schneider, Bianca Lang, Janet Ellsworth, Suzanne Ramsey, Paul Dancey, Earl Silverman, Anne-Laure Chetaille, Bonnie Cameron, Nicole Johnson, Jean Dorval, Ross E. Petty, Karen Watanabe Duffy, Gilles Boire, Elie Haddad, Kristin Houghton, Claire Saint-Cyr, Stuart E. Turvey, Susanne Benseler, Mary Cheang, Rae S. M. Yeung, Ciarán M. Duffy
DOI: 10.1002/art.24539
08/2009

Access to Pediatric Rheumatology Subspecialty Care in British Columbia, Canada
The Journal of Rheumatology
N. J. SHIFF, R. ABDWANI, D. A. CABRAL, K. M. HOUGHTON, P. N. MALLESON, R. E. PETTY, V. M. ESPINOSA, L. B. TUCKER
DOI: 10.3899/jrheum.080514
02/2009

Review for the generalist: evaluation of pediatric hip pain
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-7-10
2009

Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus
Pediatric Rheumatology
Sirirat Charuvanij, Kristin M Houghton
DOI: 10.1186/1546-0096-7-19
2009

Baseline Fitness Measures In A Cohort Of Obese Children2456
Medicine & Science in Sports & Exercise
James E. Potts, Astrid M. De Souza, Kristin M. Houghton, Shubhayan Sanatani, Walter J. Duncan, George G.S. Sandor
DOI: 10.1249/01.mss.0000322969.33832.31
05/2008

Development Of A Hospital-Based Exercise Prescription Clinic For Obese Children2457
Medicine & Science in Sports & Exercise
Astrid M. De Souza, Kristin M. Houghton, Shubhayan Sanatani, Walter J. Duncan, George G.S. Sandor, James E. Potts
DOI: 10.1249/01.mss.0000322970.10962.f9
05/2008

Aerobic and anaerobic capacity in Juvenile Idiopathic Arthritis: evaluation of the cardiorespiratory response
The Internet Journal of Rheumatology
DOI: 10.5580/201f
2008

An adolescent with both Wegener's Granulomatosis and chronic blastomycosis
Pediatric Rheumatology
Reem Abdwani, Kristin Houghton, Simon Dobson, Maureen O' Sullivan, Peter Malleson
DOI: 10.1186/1546-0096-6-13
2008

Fitness, fatigue, disease activity, and quality of life in pediatric lupus
Arthritis & Rheumatism
Kristin M. Houghton, Lori B. Tucker, James E. Potts, Donald C. Mckenzie
DOI: 10.1002/art.23534
2008

Role of activity in health and its effect on morbidity and mortality in chronic rheumatic diseases of childhood
Occupational and Physical Therapy for Children with Rheumatic Diseases: A Clinical Handbook
2008

Review for the generalist: evaluation of pediatric foot and ankle pain
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-6-6
2008

Review for the generalist: evaluation of anterior knee pain
Pediatric Rheumatology
Kristin M Houghton
DOI: 10.1186/1546-0096-5-8
2007

Systemic lupus erythematosus in the pediatric North American Native population of British Columbia
Journal of Rheumatology
PubMed: 16395763
01/2006

Old challenges and new directions in pediatric rheumatology
Journal of Rheumatology
PubMed: 16395765
01/2006

Primary Sjogren’s syndrome in dizygotic adolescent twins: one case presentation with lymphocytic interstitial pneumonia
Journal of Rheumatology
PubMed: 16078341
08/2005

Primary Sjogren’s syndrome in children and adolescents: Are current diagnostic criteria valid?
Journal of Rheumatology
2005

Clinical trial of the sensitivity to tuberculin in children referred for evaluation of Kawasaki disease
Pediatric Rheumatology Online Journal
02/2004

Research

Aerobic and anaerobic exercise capacity in Juvenile Idiopathic Arthritis
Children with juvenile idiopathic arthritis (JIA) have lower physical fitness and lower peak oxygen consumption (VO2 peak) compared to healthy children. Suboptimal VO2 peak may be due to central limitations, characterized by suboptimal heart rate response, cardiac output (CO) or oxygen saturation; or peripheral limitations, characterized by high mixed venous oxygen content (low A-VO2).

In order to examine the cardiorespiratory response during aerobic exercise and the anaerobic to aerobic ratio (metabolic index), patients with JIA and age and sex matched controls are undergoing maximal aerobic and anaerobic exercise tests on a cycle ergometer.

During aerobic exercise we measure CO (litres/minute) with Doppler echocardiography. Arterial – mixed venous oxygen index (A-VO2) and systemic vascular resistance (SVR) are calculated. We hypothesize children with JIA will have lower VO2 peak and lower anaerobic fitness (peak power and total work) than their healthy age matched peers and that children with JIA will have a different cardiorespiratory response during maximal aerobic exercise tests compared to healthy age matched peers.

Children with JIA will have less efficient muscle oxygen utilization during maximal exercise, manifest by lower arterial – venous oxygen difference (A-VO2) (corresponding to higher mixed venous oxygen difference) at a given CO and higher systemic vascular resistance (SVR). We believe better understanding of the cardiorespiratory response during exercise will allow us to more effectively prescribe exercise in children with JIA.

Evaluation of dynamic postural balance using the Biodex Balance System® in children with Juvenile Idiopathic Arthritis
Children and adults with musculoskeletal lower limb injuries are known to lose postural balance. Balance training is now accepted by sports medicine physicians as a standard component of rehabilitation. Adults with arthritis are known to lose balance. It would seem reasonable, although it is not known, that children with arthritis affecting their lower limbs also lose balance.

In this pilot study we aim to evaluate and describe postural balance in a cohort of children with JIA and children without musculoskeletal disease or injury. This pilot will provide the framework for a randomized controlled trial to evaluate the role of balance training in rehabilitation of children with arthritis.

The pilot data will be sufficient to address the hypotheses that children with JIA have poor static and dynamic balance compared to healthy children and that lower extremity strength is positively correlated with static and dynamic balance.

The primary hypothesis of the ensuing intervention trial will be that children with JIA can improve their balance with postural balance training. We believe that balance training and assessment of children with JIA will allow counselling for increased and safe participation in physical activity, decrease the risks of injury and disability, and ultimately improve the quality of life of children with JIA for both the short and long term.

Balance training might also be valuable for children with other illnesses that cause interrupted optimal physical participation.

Honours & Awards

Principal applicant Kathryn Duff PhD. Co-applicants: James E Potts PhD, William Sheel PhD, Bonnie Sawatzky PhD, Astrid DeSouza MSc. Clinical Investigator Program; Royal College of Physicians and Surgeons Fellowship Program. University of British Columbia. Funding for July 2005 to January 2007. Project title: Aerobic capacity in juvenile idiopathic arthritis: central versus peripheral limitations.

Balance in children with Juvenile Idiopathic Arthritis. Equipment grant from the Abercrombie Foundation to purchase the Biodex Balance System® ($22,148.70).

Comparing aerobic and anaerobic power during upper and lower body exercise in pediatric subjects. Pediatric Exercise Working Group. Grant from College-Wide Fund for Scholarly Activity, Douglas College ($3000.00)

Research Group Members

Felice Mizan, Research Coordinator
Angelyne Sarmiento, Research Manager