Kenneth I Lim

MD, FRCPS

Investigator, BC Children's Hospital
Head, Division of Maternal Fetal Medicine, BC Women's Hospital & Health Centre and Department of Obstetrics & Gynecology, University of British Columbia

The early treatment of fetal diseases in-utero may lead to improved outcomes for these babies. Integral to any early treatment program is the ability to evaluate the structure and physiology of the fetus in utero, both in normal and abnormal situations, as well as the animal models where therapies/theories can be tested prior to application in humans. My research interest attempts to meld all three areas towards the common goal of improved fetal therapy. Therefore, my research involves two main areas: prenatal ultrasound/imaging with regards to fetal diagnosis, disease and normal physiology; and the use of the fetal sheep model to investigate novel therapeutic approaches.

Academic Affiliations

  • Clinical Professor, , Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Pathways to Healthy Birth

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Noninvasive Respiratory Support or Intubation during Stabilization after Birth and Neonatal and Neurodevelopmental Outcomes in Infants Born Preterm at 23-25 Weeks of Gestation

Journal of Pediatrics

Lipp, R. and Beltempo, M. and Lodha, A. and Weisz, D. and McKanna, J. and Matthews, I. and Ricci, M.F. and Hicks, M. and Benlamri, A. and Mukerji, A. and Alvaro, R. and Ng, E. and Luu, T.M. and Shah, P.S. and Abou Mehrem, A. and Pillay, T. and Wong, J. and Stavel, M. and Sherlock, R. and Mehrem, A.A. and Toye, J. and Ting, J. and Fajardo, C. and Harabor, A. and Strueby, L. and Seshia, M. and Louis, D. and Ruth, C. and Yi, A. and Da Silva, O. and Augustine, S. and Lee, K.-S. and Lemyre, B. and Khurshid, F. and Bizgu, V. and Nouraeyan, N. and Barrington, K. and Lapointe, A. and Drolet, C. and Claveau, M. and St-Hilaire, M. and Bertelle, V. and Masse, E. and Barbosa de Oliveira, C. and Makary, H. and de Carvalho Nunes, G. and Alburaki, W. and Hudson, J.-A. and Afifi, J. and Kajetanowicz, A. and Piedboeuf, B. and Whittle, W. and Agarwal, S. and Lim, K. and Liauw, J. and El-Chaar, D. and Theriault, K. and Roy-Lacroix, M.-?. and Butt, K. and O'Quinn, C. and Pylypjuk, A.C. and Boucoiran, I. and Taillefer, C. and Crane, J. and Abenhaim, H. and Smith, G. and Wou, K. and Chandra, S. and Ubhi, J. and Figueiro-Filho, E. and Helewa, M. and Grigoriu, A. and Gratton, R. and Chan, C. and de Caralho Nunes, G. and Porto, L. and Melamed, N. and Burrows, J. and Wesson, L. and MacLellan, E. and Hayward, J. and Allen, V. and VanDyk, J. and Moodley, A. and Hendson, L. and Reichert, A. and Shafey, A. and Moddemann, D. and de Cabo, C. and Seesahai, J. and McKnight, S. and Coughlin, K. and Ly, L. and Raghuram, K. and Thomas, K. and Banihani, R. and Nguyen, K.-A. and Khairy, M. and Garfinkle, J. and Morin, A. and Blanger, S.

DOI: 10.1016/j.jpeds.2024.114270

Neonatal Outcomes in Hypoxic Ischemic Encephalopathy Exposed to Chorioamnionitis, a Retrospective Cohort Study

Ssrn

Gurram, S. and Fajardo, C.A. and Lee, K.-S. and da Silva, O. and Lemyre, B. and Yoon, E.W. and Shah, P.S. and Mohammad, K. and Shah, P.S. and Beltempo, M. and Kanungo, J. and Wong, J. and Stavel, M. and Sherlock, R. and Mehrem, A.A. and Toye, J. and Ting, J. and Harabor, A. and Strueby, L. and Seshia, M. and Louis, D. and Alvaro, R. and Yi, A. and Mukerji, A. and Augustine, S. and Ng, E. and Lemyre, B. and Khurshid, F. and Bizgu, V. and Barrington, K. and Lapointe, A. and Ethier, G. and Drolet, C. and Claveau, M. and St-Hilaire, M. and Bertelle, V. and Masse, E. and de Oliveira, C.B. and Makary, H. and Ojah, C. and Newman, A. and Hudson, J.-A. and Afifi, J. and Kajetanowicz, A. and Piedboeuf, B. and Whittle, W. and Agarwal, S. and Lim, K. and Liauw, J. and El-Chaar, D. and Theriault, K. and Roy-Lacroix, M.-?. and Butt, K. and O?Quinn, C. and Pylypjuk, C. and Boucoiran, I. and Taillefer, C. and Crane, J. and Abenhaim, H. and Smith, G. and Wou, K. and Chandra, S. and Ubhi, J. and Figueiro-Filho, E. and Helewa, M. and Grigoriu, A. and Gratton, R. and Chan, C. and de Caralho Nunes, G. and Porto, L. and Melamed, N. and Burrows, J. and Wesson, L. and MacLellan, E. and Hayward, J. and Allen, V.

DOI: 10.2139/ssrn.5275671

Differences in Risk Factors for Severe Preeclampsia and HELLP Syndrome in Singleton Versus Twin Pregnancies: A Population-Based Cohort Study

BJOG an International Journal of Obstetrics and Gynaecology

Campbell, M. and Koegl, J. and Bone, J.N. and Nicolls, S. and Lyons, J. and Mayer, C. and Lim, K.I. and Schalkwyk, J.V. and Joseph, K.S. and Lisonkova, S. and Christoffersen-Deb, A. and Derikvand, S. and John, S. and Richter, L. and Rougerie, M. and Sabr, Y. and Vidler, M.

DOI: 10.1111/1471-0528.18351

Maternal depressed mood and serotonergic antidepressant treatment during pregnancy differentially shape the continuity between fetal"newborn neurobehaviour

Early Human Development

Campbell, K.S.J. and Brain, U. and Hanley, G.E. and Oberlander, T.F. and Lim, K.I.

DOI: 10.1016/j.earlhumdev.2024.106129

Treating anaplastic lymphoma kinase (ALK) fusion-driven metastatic non-small cell lung cancer (NSCLC) with alectinib through pregnancy

BMJ Case Reports

Wu, F. and Rittberg, R. and Lim, K. and Ho, C.

DOI: 10.1136/bcr-2023-255575

Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study

The Lancet Digital Health

Montgomery-Csobn, T. and Kavanagh, K. and Murray, P. and Robertson, C. and Barry, S.J.E. and Vivian Ukah, U. and Payne, B.A. and Nicolaides, K.H. and Syngelaki, A. and Ionescu, O. and Akolekar, R. and Hutcheon, J.A. and Magee, L.A. and von Dadelszen, P. and Brown, M.A. and Davis, G.K. and Parker, C. and Walters, B.N. and Sass, N. and Ansermino, J.M. and Cao, V. and Cundiff, G.W. and von Dadelszen, E.C.M. and Douglas, M.J. and Dumont, G.A. and Dunsmuir, D.T. and Joseph, K.S. and Lalji, S. and Lee, T. and Li, J. and Lim, K.I. and Lisonkova, S. and Lott, P. and Menzies, J.M. and Millman, A.L. and Palmer, L. and Payne, B.A. and Qu, Z. and Russell, J.A. and Sawchuck, D. and Shaw, D. and Still, D.K. and Ukah, U.V. and Wagner, B. and Walley, K.R. and Hugo, D. and Gruslin, T.L.A. and Tawagi, G. and Smith, G.N. and Ct, A.-M. and Moutquin, J.-M. and Ouellet, A.B. and Lee, S.K. and Duan, T. and Zhou, J. and Haniff, T.L.F. and Mahajan, S. and Noovao, A. and Karjalainend, H. and Kortelainen, A. and Laivuori, H. and Ganzevoort, J.W. and Groen, H. and Kyle, P.M. and Moore, M.P. and Pullar, B. and Bhutta, Z.A. and Qureshi, R.N. and Sikandar, R. and Bhutta, T.L.S.Z. and Cloete, G. and Hall, D.R. and van Papendorp, T.L.E. and Steyn, D.W. and Biryabarema, C. and Mirembe, F. and Nakimuli, A. and Allotey, J. and Thangaratinam, S. and de Swiet, M. and Magee, L.A. and Walker, J.J. and Robson, S.C. and Broughton-Pipkin, F. and Loughna, P. and Vatish, M. and Redman, C.W.G. and Barry, S.J.E. and Montgomery-Csobn, T. and Tsigas, E.Z. and Woelkers, D.A. and Lindheimer, M.D. and Grobman, W.A. and Sibai, B.M. and Merialdi, M. and Widmer, M.

DOI: 10.1016/S2589-7500(23)00267-4

Variations in Site-Specific Costs for Infants Born Extremely Preterm in Canadian Neonatal Intensive Care Units

Journal of Pediatrics

Yeung, T. and Ahmed, A. and Wong, J. and Toye, J. and Abou Mehrem, A. and Mukerji, A. and Lapointe, A. and Ng, E. and Beltempo, M. and Pechlivanoglou, P. and Lee, S. and Shah, P.S. and Whittle, W. and Agarwal, S. and Lim, K. and El-Chaar, D. and Theriault, K. and Roy-Lacroix, M.-?. and Butt, K. and O'Quinn, C. and Pylypjuk, C. and Boucoiran, I. and Taillefer, C. and Crane, J. and Abenhaim, H. and Smith, G. and Wou, K. and Chandra, S. and Ubhi, J. and Figueiro-Filho, E. and Helewa, M. and Grigoriu, A. and Gratton, R. and Chan, C. and de Caralho Nunes, G. and Porto, L. and Melamed, N. and Burrows, J. and Augustine, S. and Wesson, L. and MacLellan, E. and Hayward, J. and Allen, V.

DOI: 10.1016/j.jpeds.2023.113863

Guideline No. 441: Antenatal Fetal Health Surveillance

Journal of Obstetrics and Gynaecology Canada

Niles, K.M. and Jain, V. and Chan, C. and Choo, S. and Dore, S. and Kiely, D.J. and Lim, K. and Roy Lacroix, M.-E. and Sharma, S. and Waterman, E.

DOI: 10.1016/j.jogc.2023.05.020

Directive clinique no 441: Surveillance prnatale du bien-tre f"tal

Journal of Obstetrics and Gynaecology Canada

Niles, K.M. and Jain, V. and Chan, C. and Choo, S. and Dore, S. and Kiely, D.J. and Lim, K. and Roy-Lacroix, M.-?. and Sharma, S. and Waterman, E.

DOI: 10.1016/j.jogc.2023.05.021

Mise jour technique no 352: Le rle de l'examen chographique prcoce et exhaustif de l'anatomie f"tale

Journal of Obstetrics and Gynaecology Canada

Nevo, O. and Brown, R. and Glanc, P. and Lim, K.

DOI: 10.1016/j.jogc.2023.07.002

The Canadian STRIDER Randomised Controlled Trial of Sildenafil for Severe, Early-onset Fetal Growth Restriction

ResearchSquare

von Dadelszen, P. and Audibert, F. and Bujold, E. and Bone, J.N. and Sandhu, A. and Li, J. and Kariya, C. and Chung, Y. and Lee, T. and Au, K. and Skoll, M.A. and Vidler, M. and Magee, L.A. and Piedboeuf, B. and Baker, P.N. and Lalji, S. and Lim, K.I.

DOI: 10.21203/rs.3.rs-1234974

Halting the Canadian STRIDER randomised controlled trial of sildenafil for severe, early-onset fetal growth restriction: ethical, methodological, and pragmatic considerations

BMC Research Notes

von Dadelszen, P. and Audibert, F. and Bujold, E. and Bone, J.N. and Sandhu, A. and Li, J. and Kariya, C. and Chung, Y. and Lee, T. and Au, K. and Skoll, M.A. and Vidler, M. and Magee, L.A. and Piedboeuf, B. and Baker, P.N. and Lalji, S. and Lim, K.I.

DOI: 10.1186/s13104-022-06107-y

Directive clinique no 428: Prise en charge de la grossesse gmellaire bichoriale

Journal of Obstetrics and Gynaecology Canada

Mei-Dan, E. and Jain, V. and Melamed, N. and Lim, K.I. and Aviram, A. and Ryan, G. and Barrett, J.

DOI: 10.1016/j.jogc.2022.05.003

Guideline No. 428: Management of Dichorionic Twin Pregnancies

Journal of Obstetrics and Gynaecology Canada

Mei-Dan, E. and Jain, V. and Melamed, N. and Lim, K.I. and Aviram, A. and Ryan, G. and Barrett, J.

DOI: 10.1016/j.jogc.2022.05.002

Glycine, a Dispensable Amino Acid, Is Conditionally Indispensable in Late Stages of Human Pregnancy

Journal of Nutrition

Rasmussen, B.F. and Ennis, M.A. and Dyer, R.A. and Lim, K. and Elango, R.

DOI: 10.1093/jn/nxaa263

Prenatal Detection of a Sublingual Lymphatic Malformation in a Fetus: A Rare Case

Journal of Obstetrics and Gynaecology Canada

McCuaig, S. and Ghaeni, D. and Weatherhead, L. and Pavlova, N. and Lim, K.

DOI: 10.1016/j.jogc.2021.03.021

Short-term outcomes of phosphodiesterase type 5 inhibitors for fetal growth restriction: a study protocol for a systematic review with individual participant data meta-analysis, aggregate meta-analysis, and trial sequential analysis

Systematic Reviews

Liauw, J. and Groom, K. and Ganzevoort, W. and Gluud, C. and McKinlay, C.J.D. and Sharp, A. and Mackay, L. and Kariya, C. and Lim, K. and von Dadelszen, P. and Limpens, J. and Jakobsen, J.C. and Audibert, F. and Alfirevic, Z. and Baker, P. and Bujold, E. and Chung, Y. and Cornforth, C. and Ganzevoort, W. and Gordijn, S.J. and Gluud, C. and Jakobsen, J.C. and Johnstone, E.D. and Kariya, C. and Kenny, L. and Lee, T. and Li, L. and Liauw, J. and Lim, K. and Magee, L. and Mackay, L. and McCowan, L. and McKinlay, C. and Mol, B.W. and Onland, W. and Papageorghiou, A. and Pels, A. and Sharp, A. and von Dadelszen, P.

DOI: 10.1186/s13643-021-01849-5

Maternal Serotonin Reuptake Inhibitor Antidepressants Have Acute Effects on Fetal Heart Rate Variability in Late Gestation

Frontiers in Psychiatry

Campbell, K.S.J. and Collier, A.C. and Irvine, M.A. and Brain, U. and Rurak, D.W. and Oberlander, T.F. and Lim, K.I.

DOI: 10.3389/fpsyt.2021.680177

Dietary Aromatic Amino Acid Requirements During Early and Late Gestation in Healthy Pregnant Women.

The Journal of nutrition

Ennis MA and Ong AJ and Lim K and Ball RO and Pencharz PB and Courtney-Martin G and Elango R

DOI: 10.1093/jn/nxaa317 PubMed: 33188409

12 / 2020

Guideline No. 401: Sonographic Cervical Length in Singleton Pregnancies: Techniques and Clinical Applications.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Lim KI and Butt K and Nevo O and Crane JM

DOI: 10.1016/j.jogc.2019.06.002 PubMed: 33189242

11 / 2020

Directive clinique no401: Mesure chographique de la longueur du col en cas de grossesse monof"tale: Techniques et applications cliniques.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Lim KI and Butt K and Nevo O and Crane JM

DOI: 10.1016/j.jogc.2020.09.011 PubMed: 33189243

11 / 2020

Cuffless single-site photoplethysmography for blood pressure monitoring

Journal of Clinical Medicine

Hosanee, M. and Chan, G. and Welykholowa, K. and Cooper, R. and Kyriacou, P.A. and Zheng, D. and Allen, J. and Abbott, D. and Menon, C. and Lovell, N.H. and Howard, N. and Chan, W.-S. and Lim, K. and Fletcher, R. and Ward, R. and Elgendi, M.

DOI: 10.3390/jcm9030723

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

The Lancet Diabetes and Endocrinology

Feig, D.S. and Donovan, L.E. and Zinman, B. and Sanchez, J.J. and Asztalos, E. and Ryan, E.A. and Fantus, I.G. and Hutton, E. and Armson, A.B. and Lipscombe, L.L. and Simmons, D. and Barrett, J.F.R. and Karanicolas, P.J. and Tobin, S. and McIntyre, H.D. and Tian, S.Y. and Tomlinson, G. and Murphy, K.E. and Feig, D. and Donat, D. and Gandhi, S. and Cleave, B. and Zhou, V. and Viguiliouk, E. and Fong, D. and Strom, M. and Deans, M. and Kamath, A. and Godbout, A. and Weber, F. and Mahone, M. and Wo, B.L. and Bedard, M.-J. and Robinson, M. and Daigle, S. and Leblanc, S. and Ludwig, S. and Pockett, S. and Slater, L. and Donovan, L. and Oldford, C. and Young, C. and Virtanen, H. and Lodha, A. and Cooper, S. and Yamamoto, J. and Gougeon, C. and Verhesen, C. and Zahedi, A. and Taha, N. and Turner, M. and Neculau, M. and Robb, C. and Szwiega, K. and Lee, G. and Rey, E. and Perreault, S. and Coolen, J. and Ransom, T. and Dias, R. and Slaunwhite, J. and Baxendale, D. and Fanning, C. and Halperin, I. and Gale, V. and Kader, T. and Hirsimaki, H. and Long, H. and Lambert, J. and Castonguay, A. and Chalifoux, S. and McManus, R. and Watson, M. and Powell, A.-M. and Sultana, M. and ArthurHayward, V. and Marin, M. and Cauchi, L. and MacBean, L. and Keely, E. and Malcolm, J. and Clark, H. and Karovitch, A. and Belanger, H. and Champagne, J. and Schutt, K. and Sloan, J. and Mitchell, J. and Favreau, C. and O'Shea, E. and McGuire, D. and Peng, M. and St Omer, D. and Lee, J. and Klinke, J. and Young, S. and Barts, A. and Carr, F. and Subrt, P. and Miller, D. and Coles, K. and Capes, S. and Smushkin, G. and Phillips, R. and Fergusson, C. and Lacerte, S. and Houlden, R. and Breen, A. and Stone-Hope, B. and Kwong, S. and Rylance, H. and Khurana, R. and McNab, T. and Beauchamp, S. and Weisnagel, S.J. and D'Amours, M. and Allen, C. and Dub, M.-C. and Julien, V.-?. and Lambert, C. and Bourbonniere, M.-C. and Rheaume, L. and Bouchard, M. and Carson, G. and Williams, S. and Wolfs, M. and Berger, H. and Cheng, A. and Ray, J. and Hanna, A. and De Souza, L. and Berndl, L. and Meltzer, S. and Garfield, N. and El-Messidi, A. and Bastien, L. and Segal, S. and Thompson, D. and Lim, K. and Kong, J. and Thompson, S. and Orr, C. and Galway, B. and Parsons, M. and Rideout, K. and Rowe, B. and Crane, J. and Andrews, W. and Joyce, C. and Newstead-Angel, J. and Brandt, J. and Meier, S. and Laurie, J. and McIntyre, D. and Liley, H. and Fox, J. and Barrett, H. and Maguire, F. and Nerdal-Bussell, M. and Nie, W. and Bergan, C. and Cavallaro, B. and Tremellen, A. and Cook, A. and Rajagopal, R. and Vizza, L. and Mattick, M. and Bishop, C. and Nema, J. and Kludas, R. and McLean, M. and Hendon, S. and Sigmund, A. and Wong, V. and Lata, P. and Russell, H. and Singh, R. and Barrett, J. and Murphy, K. and McMurray, K. and Karanicolas, P. and Murphy, H. and Sanchez, J. and Klein, G. and Tian, S. and Mangoff, K.

DOI: 10.1016/S2213-8587(20)30310-7

Dietary phenylalanine requirements during early and late gestation in healthy pregnant women

American Journal of Clinical Nutrition

Ennis, M.A. and Rasmussen, B.F. and Lim, K. and Ball, R.O. and Pencharz, P.B. and Courtney-Martin, G. and Elango, R.

DOI: 10.1093/ajcn/nqz288

Multimodal photoplethysmography-based approaches for improved detection of hypertension

Journal of Clinical Medicine

Welykholowa, K. and Hosanee, M. and Chan, G. and Cooper, R. and Kyriacou, P.A. and Zheng, D. and Allen, J. and Abbott, D. and Menon, C. and Lovell, N.H. and Howard, N. and Chan, W.-S. and Lim, K. and Fletcher, R. and Ward, R. and Elgendi, M.

DOI: 10.3390/jcm9041203

Association between gestational weight gain and severe adverse birth outcomes in Washington State, US: A population-based retrospective cohort study, 2004-2013

PLoS Medicine

Vivian Ukah, U. and Bayrampour, H. and Sabr, Y. and Razaz, N. and Chan, W.-S. and Lim, K.I. and Lisonkova, S.

DOI: 10.1371/journal.pmed.1003009

No. 383-Screening, Diagnosis, and Management of Placenta Accreta Spectrum Disorders

Journal of Obstetrics and Gynaecology Canada

Hobson, S.R. and Kingdom, J.C. and Murji, A. and Windrim, R.C. and Carvalho, J.C.A. and Singh, S.S. and Ziegler, C. and Birch, C. and Frecker, E. and Lim, K. and Cargill, Y. and Allen, L.M.

DOI: 10.1016/j.jogc.2018.12.004

How Effective is Pulse Arrival time for Evaluating Blood Pressure? Challenges and Recommendations from a study using the MIMIC Database

Journal of Clinical Medicine

Liang, Y. and Abbott, D. and Howard, N. and Lim, K. and Ward, R. and Elgendi, M.

DOI: 10.3390/jcm8030337

Temporal trends in neonatal mortality and morbidity following spontaneous and clinician-initiated preterm birth in Washington State, USA: A population-based study

BMJ Open

Richter, L.L. and Ting, J. and Muraca, G.M. and Synnes, A. and Lim, K.I. and Lisonkova, S.

DOI: 10.1136/bmjopen-2018-023004

Directive clinique No 388 - Dtermination de lge gestationnel par chographie

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Lim, K.I.

DOI: 10.1016/j.jogc.2019.04.011

Reply

Ultrasound in Obstetrics and Gynecology

Groom, K.M. and Ganzevoort, W. and Alfirevic, Z. and Lim, K. and Papageorghiou, A.T.

DOI: 10.1002/uog.20202

No 383 " Dpistage, diagnostic et prise en charge des troubles du spectre du placenta accreta

Journal of Obstetrics and Gynaecology Canada

Hobson, S.R. and Kingdom, J.C. and Murji, A. and Windrim, R.C. and Carvalho, J.C.A. and Singh, S.S. and Ziegler, C. and Birch, C. and Frecker, E. and Lim, K. and Cargill, Y. and Allen, L.M.

DOI: 10.1016/j.jogc.2019.04.002

No. 374-Universal Cervical Length Screening

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Crane, J. and Hutcheon, J. and Lim, K. and Nevo, O.

DOI: 10.1016/j.jogc.2018.09.019

The use of photoplethysmography for assessing hypertension

npj Digital Medicine

Elgendi, M. and Fletcher, R. and Liang, Y. and Howard, N. and Lovell, N.H. and Abbott, D. and Lim, K. and Ward, R.

DOI: 10.1038/s41746-019-0136-7

No. 304-Joint SOGC/CAR Policy Statement on Non-medical Use of Fetal Ultrasound

Journal of Obstetrics and Gynaecology Canada

Salem, S. and Lim, K. and Van den Hof, M.C.

DOI: 10.1016/j.jogc.2018.11.022

Guideline No. 388-Determination of Gestational Age by Ultrasound

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Lim, K.I.

DOI: 10.1016/j.jogc.2019.04.010

Stillbirth Associated With Birth Weight Discordance in Twin Gestations

Journal of Obstetrics and Gynaecology Canada

Jahanfar, S. and Lim, K. and Oviedo-Joekes, E.

DOI: 10.1016/j.jogc.2018.02.017

No 304 - Dclaration de principe commune SOGC/CAR sur l'utilisation non mdicale de lchographie f"tale

Journal of Obstetrics and Gynaecology Canada

Salem, S. and Lim, K. and Van den Hof, M.C.

DOI: 10.1016/j.jogc.2018.11.023

N o 374 - valuation systmatique de la longueur cervicale

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Crane, J. and Hutcheon, J. and Lim, K. and Nevo, O.

DOI: 10.1016/j.jogc.2019.01.003

Can photoplethysmography replace arterial blood pressure in the assessment of blood pressure?

Journal of Clinical Medicine

Martnez, G. and Howard, N. and Abbott, D. and Lim, K. and Ward, R. and Elgendi, M.

DOI: 10.3390/jcm7100316

Is there a relationship between fetal sex and placental pathological characteristics in twin gestations?

BMC Pregnancy and Childbirth

Jahanfar, S. and Lim, K.

DOI: 10.1186/s12884-018-1896-9

Clinicians should stop prescribing sildenafil for fetal growth restriction (FGR): comment from the STRIDER Consortium

Ultrasound in Obstetrics and Gynecology

Groom, K.M. and Ganzevoort, W. and Alfirevic, Z. and Lim, K. and Papageorghiou, A.T. and Alfirevic, Z. and Ganzevoort, W. and M. Groom, K. and Lim, K. and Baker, P. and von Dadelszen, P. and Gluud, C. and Jakobsen, J. and Papageorghiou, A.T. and Kenny, L. and Magee, L. and Kariya, C. and Lee, T. and Li, L. and Pels, A.

DOI: 10.1002/uog.19186

Viagra for fetal growth restriction: STRIDER Consortium replies to letter by Symonds and Budge

BMJ (Online)

Kenny, L.C. and Alfirevic, Z. and Baker, P.N. and Ganzevoort, W. and Gluud, C. and Groom, K.M. and Jakobsen, J.C. and Lim, K. and Magee, L.A. and Papageorghiou, A.T. and Von Dadelszen, P.

DOI: 10.1136/bmj.k4872

Variations from morning to afternoon of middle cerebral and umbilical artery blood flow, and fetal heart rate variability, and fetal characteristics in the normally developing fetus

Journal of Clinical Ultrasound

Avitan, T. and Sanders, A. and Brain, U. and Rurak, D. and Oberlander, T.F. and Lim, K.

DOI: 10.1002/jcu.22569

The STRIDER trials: ongoing research

The Lancet Child and Adolescent Health

Ganzevoort, W. and Gluud, C. and Lim, K. and Mol, B. and Groom, K.

DOI: 10.1016/S2352-4642(18)30036-1

Temporal trends in severe maternal and neonatal trauma during childbirth: A population-based observational study

BMJ Open

Wen, Q. and Muraca, G.M. and Ting, J. and Coad, S. and Lim, K.I. and Lisonkova, S.

DOI: 10.1136/bmjopen-2017-020578

No 257-Recours l'valuation chographique de la longueur cervicale pour prdire l'accouchement prterme dans le cadre de grossesses monof"tales

Journal of Obstetrics and Gynaecology Canada

Lim, K. and Butt, K. and Crane, J.M.

DOI: 10.1016/j.jogc.2017.11.017

Placental pathology findings and birth weight discordance

Clinical and Experimental Obstetrics and Gynecology

Jahanfar, S. and Lim, K.

DOI: 10.12891/ceog3740.2018

No. 257-Ultrasonographic Cervical Length Assessment in Predicting Preterm Birth in Singleton Pregnancies

Journal of Obstetrics and Gynaecology Canada

Lim, K. and Butt, K. and Crane, J.M.

DOI: 10.1016/j.jogc.2017.11.016

Lysine requirements of healthy pregnant women are higher during late stages of gestation compared to early gestation

Journal of Nutrition

Payne, M. and Stephens, T. and Lim, K. and Ball, R.O. and Pencharz, P.B. and Elango, R.

DOI: 10.1093/jn/nxx034

Outcomes of Selective Reduction of DCDA Twins Complicated by PV-PROM Compared with Expectant Management: A Case Series and Review of the Literature

Journal of Obstetrics and Gynaecology Canada

Lim, B. and Butler, B. and Gagnon, A. and Lim, K. and Marquette, G. and Dahlgren, L.

DOI: 10.1016/j.jogc.2017.09.015

STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials.

BMC pregnancy and childbirth

Pels A and Kenny LC and Alfirevic Z and Baker PN and von Dadelszen P and Gluud C and Kariya CT and Mol BW and Papageorghiou AT and van Wassenaer-Leemhuis AG and Ganzevoort W and international STRIDER Consortium

DOI: 10.1186/s12884-017-1594-z PubMed: 29282009

12 / 2017

Birth weight discordance and adverse perinatal outcomes

Journal of Perinatal Medicine

Jahanfar, S. and Lim, K. and Ovideo-Joekes, E.

DOI: 10.1515/jpm-2016-0089

N 260-chographie et grossesse gmellaire

Journal of Obstetrics and Gynaecology Canada

Morin, L. and Lim, K.

DOI: 10.1016/j.jogc.2017.08.019

No 352 " Mise jour technique: Le rle de l'examen chographique prcoce et exhaustif de l'anatomie f"tale

Journal of Obstetrics and Gynaecology Canada

Nevo, O. and Brown, R. and Glanc, P. and Lim, K.

DOI: 10.1016/j.jogc.2017.09.009

Mise jour technique sur la physiologie et lvaluation du liquide amniotique

Journal of Obstetrics and Gynaecology Canada

Lim, K.I. and Butt, K. and Naud, K. and Smithies, M.

DOI: 10.1016/j.jogc.2016.12.001

Amniotic Fluid: Technical Update on Physiology and Measurement

Journal of Obstetrics and Gynaecology Canada

Lim, K.I. and Butt, K. and Naud, K. and Smithies, M.

DOI: 10.1016/j.jogc.2016.09.012

Adverse maternal outcomes and birth weight discordance in twin gestation: British Columbia, Canadian data

International Journal of Women's Health

Jahanfar, S. and Lim, K.

DOI: 10.2147/IJWH.S115515

Gadolinium magnetic resonance imaging during pregnancy associated with adverse neonatal and post-neonatal outcomes

Journal of Pediatrics

Potts, J. and Lisonkova, S. and Murphy, D.T. and Lim, K.

DOI: 10.1016/j.jpeds.2016.10.061

No. 260-Ultrasound in Twin Pregnancies

Journal of Obstetrics and Gynaecology Canada

Morin, L. and Lim, K.

DOI: 10.1016/j.jogc.2017.08.014

Association between prepregnancy body mass index and severe maternal morbidity

JAMA - Journal of the American Medical Association

Lisonkova, S. and Muraca, G.M. and Potts, J. and Liauw, J. and Chan, W.-S. and Skoll, A. and Lim, K.I.

DOI: 10.1001/jama.2017.16191

Rationale and recommendations for improving definitions, registration requirements and procedures related to fetal death and stillbirth

BJOG: An International Journal of Obstetrics and Gynaecology

Joseph, K.S. and Basso, M. and Davies, C. and Lee, L. and Ellwood, D. and Fell, D.B. and Fowler, D. and Kinniburgh, B. and Kramer, M.S. and Lim, K. and Selke, P. and Shaw, D. and Sneddon, A. and Sprague, A. and Williams, K.

DOI: 10.1111/1471-0528.14242

No. 352-Technical Update: The Role of Early Comprehensive Fetal Anatomy Ultrasound Examination

Journal of Obstetrics and Gynaecology Canada

Nevo, O. and Brown, R. and Glanc, P. and Lim, K.

DOI: 10.1016/j.jogc.2017.06.031

Effect of folic acid food fortification in Canada on congenital heart disease subtypes

Circulation

Liu, S. and Joseph, K.S. and Luo, W. and Len, J.A. and Lisonkova, S. and Van Den Hof, M. and Evans, J. and Lim, K. and Little, J. and Sauve, R. and Kramer, M.S.

DOI: 10.1161/CIRCULATIONAHA.116.022126

The Impact of Gender on Anthropometric Measures of Twins

Twin Research and Human Genetics

Jahanfar, S. and Lim, K.

DOI: 10.1017/thg.2016.57

Utilisation de l'imagerie par rsonance magntique en obsttrique

Journal of Obstetrics and Gynaecology Canada

Patenaude, Y. and Pugash, D. and Lim, K. and Morin, L.

DOI: 10.1016/j.jogc.2016.09.051

Determination of Gestational Age by Ultrasound: In Response

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Lim, K.

DOI: 10.1016/j.jogc.2016.04.003

Optimal threshold for birth weight discordance: Does knowledge of chorionicity matter?

Journal of Perinatology

Jahanfar, S. and Lim, K. and Oviedo-Joekes, E.

DOI: 10.1038/jp.2016.82

Maternal morbidity and perinatal outcomes among women in rural versus urban areas

CMAJ

Lisonkova, S. and Haslam, M.D. and Dahlgren, L. and Chen, I. and Synnes, A.R. and Lim, K.I.

DOI: 10.1503/cmaj.151382

Dtermination de l'ge gestationnel par chographie

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Lim, K.

DOI: 10.1016/j.jogc.2016.09.048

Dclaration de principe commune SOGC/CAR sur l'utilisation non mdicale de lchographie f"tal

Journal of Obstetrics and Gynaecology Canada

Salem, S. and Lim, K. and Van den Hof, M.C.

DOI: 10.1016/j.jogc.2016.09.049

The authors respond

CMAJ

Lisonkova, S. and Lim, K.I. and Synnes, A.R.

DOI: 10.1503/cmaj.1150132

Evaluation of the International Association of the Diabetes in Pregnancy Study Group New Criteria: Gestational Diabetes Project

Canadian Journal of Diabetes

Kong, J.M. and Lim, K. and Thompson, D.M.

DOI: 10.1016/j.jcjd.2014.09.007

Determination of gestational age by ultrasound,Dtermination de l'ge gestationnel par chographie

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Lim, K. and Bly, S. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Salem, S.

DOI: 10.1016/S1701-2163(15)30665-4

Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes

Diabetologia

Kallas-Koeman, M.M. and Kong, J.M. and Klinke, J.A. and Butalia, S. and Lodha, A.K. and Lim, K.I. and Duan, Q.M. and Donovan, L.E.

DOI: 10.1007/s00125-014-3163-6

The Use of Magnetic Resonance Imaging in the Obstetric Patient

Journal of Obstetrics and Gynaecology Canada

Patenaude, Y. and Pugash, D. and Lim, K. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Naud, K. and Ouellet, A. and Salem, S.

DOI: 10.1016/S1701-2163(15)30612-5

The impact of maternal positive and negative affect on fetal physiology and diurnal patterns

Israel Journal of Psychiatry and Related Sciences

Hanley, G.E. and Rurak, D. and Lim, K. and Brain, U. and Oberlander, T.F.

Joint SOGC/CAR Policy Statement on Non-medical Use of Fetal Ultrasound

Journal of Obstetrics and Gynaecology Canada

Salem, S. and Lim, K. and Harris, A. and Van den Hof, M.C. and Naud, K. and Keough, V. and Bly, S. and Cargill, Y. and O'Sullivan, J. and Butt, K. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Vickar, D. and Lautner, D. and Patenaude, Y.

DOI: 10.1016/S1701-2163(15)30666-6

A SYSTEMATIC REVIEW of BIRTH WEIGHT DISCORDANCE and PERINATAL OUTCOMES

Fetal and Maternal Medicine Review

Jahanfar, S. and Lim, K.

DOI: 10.1017/S0965539516000012

The effect of hyperinsulinemia and hyperglycemia on endothelial function in pregnant patients with type-2 diabetes

Diabetes Research and Clinical Practice

Khurana, R. and Meneilly, G.S. and Lim, K. and Thompson, D.

DOI: 10.1016/j.diabres.2013.12.053

Joint SOGC/CAR policy statement on non-medical use of fetal ultrasound,Dclaration de principe commune SOGC/CAR sur l'utilisation non mdicale de l'chographie foetale

Journal of Obstetrics and Gynaecology Canada

Salem, S. and Lim, K. and Harris, A. and Van den Hof, M.C. and Keough, V. and Naud, K. and Bly, S. and Cargill, Y. and O'Sullivan, J. and Butt, K. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Vickar, D. and Lautner, D. and Patenaude, Y.

DOI: 10.1016/S1701-2163(15)30667-8

Determination of Gestational Age by Ultrasound

Journal of Obstetrics and Gynaecology Canada

Butt, K. and Lim, K. and Bly, S. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Salem, S.

DOI: 10.1016/S1701-2163(15)30664-2

The use of magnetic resonance imaging in the obstetric patient,Utilisation de l'imagerie par rsonance magntique en obsttrique

Journal of Obstetrics and Gynaecology Canada

Patenaude, Y. and Pugash, D. and Lim, K. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Naud, K. and Ouellet, A. and Salem, S.

DOI: 10.1016/S1701-2163(15)30613-7

An assessment of predictive value of the biophysical profile in women with preeclampsia using data from the fullPIERS database

Pregnancy Hypertension

Payne, B.A. and Kyle, P.M. and Lim, K. and Lisonkova, S. and Magee, L.A. and Pullar, B. and Qu, Z. and Von Dadelszen, P.

DOI: 10.1016/j.preghy.2013.03.001

Immortal time bias in the study of stillbirth risk factors: The example of gestational diabetes

Epidemiology

Hutcheon, J.A. and Kuret, V. and Joseph, K.S. and Sabr, Y. and Lim, K.

DOI: 10.1097/EDE.0b013e3182a6d9aa

The Case for Universal Cervical Length Screening to Prevent Preterm Birth: Is it Strong Enough to Change Practice in Canada?

Journal of Obstetrics and Gynaecology Canada

Hutcheon, J.A. and Amanda Skoll, M. and Eastabrook, G.D. and Lim, K.I. and on behalf of the University of British Columbia Division of Maternal-Fetal Medicine

DOI: 10.1016/S1701-2163(16)35467-6

Reversed umbilical arterial end diastolic flow, sildenafil treatment and early stillbirths

BJOG: An International Journal of Obstetrics and Gynaecology

Von Dadelszen, P. and Lim, K.I. and Dwinnell, S. and Magee, L.A. and Carleton, B.C. and Gruslin, A. and Lee, B. and Liston, R.M. and Miller, S.P. and Rurak, D. and Sherlock, R.L. and Skoll, M.A. and Wareing, M.M. and Baker, P.N.

DOI: 10.1111/j.1471-0528.2011.03263.x

Prediction of pediatric outcome after prenatal diagnosis and expectant antenatal management of congenital cystic adenomatoid malformation

Fetal Diagnosis and Therapy

Yong, P.J. and Von Dadelszen, P. and Carpara, D. and Lim, K. and Kent, N. and Tessier, F. and Delisle, M.-F. and Wong, T. and Blair, G. and Skarsgard, E.D.

DOI: 10.1159/000331936

Population-based review of tetralogy of Fallot with absent pulmonary valve: Is prenatal diagnosis really associated with a poor prognosis?

Ultrasound in Obstetrics and Gynecology

Mivelaz, Y. and Lim, K.I. and Templeton, C. and Campbell, A.I. and Potts, J.E. and Sandor, G.G.S.

DOI: 10.1002/uog.11126

Third trimester fetal pulmonary artery Doppler blood flow velocity characteristics following prenatal selective serotonin reuptake inhibitor (SSRI) exposure

Early Human Development

Lim, K. and Sanders, A. and Brain, U. and Riggs, W. and Oberlander, T.F. and Rurak, D.

DOI: 10.1016/j.earlhumdev.2012.01.004

Ultrasound in Twin Pregnancies

Journal of Obstetrics and Gynaecology Canada

DOI: 10.1016/s1701-2163(16)34916-7

06 / 2011

chographie et grossesse gmellaire

Journal of Obstetrics and Gynaecology Canada

DOI: 10.1016/s1701-2163(16)34917-9

06 / 2011

Ultrasonographic Cervical Length Assessment in Predicting Preterm Birth in Singleton Pregnancies

Journal of Obstetrics and Gynaecology Canada

DOI: 10.1016/s1701-2163(16)34884-8

05 / 2011

Recours lvaluation chographique de la longueur cervicale pour prdire laccouchement prterme dans le cadre de grossesses monof"tales

Journal of Obstetrics and Gynaecology Canada

DOI: 10.1016/s1701-2163(16)34885-x

05 / 2011

SOGC Clinical Practice Guideline. Ultrasonographic cervical length assessment in predicting preterm birth in singleton pregnancies.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obsttrique et gyncologie du Canada : JOGC

Lim, K. and Butt, K. and Crane, J.M.

Third trimester fetal heart rate and doppler middle cerebral artery blood flow velocity characteristics during prenatal selective serotonin reuptake inhibitor exposure

Pediatric Research

Rurak, D. and Lim, K. and Sanders, A. and Brain, U. and Riggs, W. and Oberlander, T.F.

DOI: 10.1203/PDR.0b013e31821ba11a

Sildenafil citrate therapy for severe early-onset intrauterine growth restriction

BJOG: An International Journal of Obstetrics and Gynaecology

Von Dadelszen, P. and Dwinnell, S. and Magee, L.A. and Carleton, B.C. and Gruslin, A. and Lee, B. and Lim, K.I. and Liston, R.M. and Miller, S.P. and Rurak, D. and Sherlock, R.L. and Skoll, M.A. and Wareing, M.M. and Baker, P.N.

DOI: 10.1111/j.1471-0528.2010.02879.x

Guidelines for the Management of Vasa Previa

Journal of Obstetrics and Gynaecology Canada

Gagnon, R. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Anne Hietala-Coyle, M. and Lim, K.I. and Ouellet, A. and Racicot, M.-H. and Salem, S. and Hudon, L. and Basso, M. and Bos, H. and Delisle, M.-F. and Farine, D. and Grabowska, K. and Menticoglou, S. and Mundle, W. and Murphy-Kaulbeck, L. and Pressey, T. and Roggensack, A.

DOI: 10.1016/S1701-2163(16)34282-7

Initial evaluation and referral guidelines for management of pelvic/ovarian masses,Prise en charge des masses pelviennes/ovariennes: valuation initiale et lignes directrices quant l'orientation des patientes

Journal of Obstetrics and Gynaecology Canada

Le, T. and Giede, C. and Salem, S. and Lefebvre, G. and Rosen, B. and Bentley, J. and Kupets, R. and Power, P. and Renaud, M.-C. and Bryson, P. and Davis, D.B. and Lau, S. and Lotocki, R. and Senikas, V. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Gagnon, R. and Hietala-Coyle, M.A. and Lim, K.I. and Ouellet, A. and Racicot, M.-H.

DOI: 10.1016/S1701-2163(16)34255-4

Initial Evaluation and Referral Guidelines for Management of Pelvic/Ovarian Masses

Journal of Obstetrics and Gynaecology Canada

Le, T. and Giede, C. and Salem, S. and Lefebvre, G. and Rosen, B. and Bentley, J. and Kupets, R. and Power, P. and Renaud, M.-C. and Bryson, P. and Davis, D.B. and Lau, S. and Lotocki, R. and Senikas, V. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Gagnon, R. and Anne Hietala-Coyle, M. and Lim, K.I. and Ouellet, A. and Racicot, M.-H.

DOI: 10.1016/S1701-2163(16)34254-2

Content of a Complete Routine Second Trimester Obstetrical Ultrasound Examination and Report

Journal of Obstetrics and Gynaecology Canada

Cargill, Y. and Morin, L. and Bly, S. and Butt, K. and Denis, N. and Gagnon, R. and Hietala-Coyle, M.A. and Lim, K. and Ouellet, A. and Racicot, M.-H. and Salem, S.

DOI: 10.1016/S1701-2163(16)34127-5

Guidelines for the management of vasa previa,Directive clinique sur la prise en charge du vasa praevia

Journal of Obstetrics and Gynaecology Canada

Gagnon, R. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Hietala-Coyle, M.A. and Lim, K.I. and Ouellet, A. and Racicot, M. and Salem, S. and Hudon, L. and Basso, M. and Bos, H. and Delisle, M.-F. and Farine, D. and Grabowska, K. and Menticoglou, S. and Mundle, W. and Murphy-Kaulbeck, L. and Pressey, T. and Roggensack, A.

DOI: 10.1016/S1701-2163(16)34283-9

Content of a complete routine second trimester obstetrical ultrasound examination and report,Tenue systmatique d'un examen chographique obsttrical au cours du deuxime trimestre: Contenu d'un examen et d'un rapport exhaustifs

Journal of Obstetrics and Gynaecology Canada

Cargill, Y. and Morin, L. and Bly, S. and Butt, K. and Denis, N. and Gagnon, R. and Hietala-Coyle, M.A. and Lim, K. and Ouellet, A. and Racicot, M.-H. and Salem, S.

DOI: 10.1016/S1701-2163(16)34128-7

Non-medical use of fetal ultrasound,Utilisation non mdicale de l'chographie f"tale

Journal of Obstetrics and Gynaecology Canada

Van den Hof, M.C. and Bly, S. and Gagnon, R. and Lewthwaite, B. and Lim, K. and Morin, L. and Salem, S.

DOI: 10.1016/S1701-2163(16)32427-6

Origin and outcome of pregnancies affected by androgenetic/biparental chimerism

Human Reproduction

Robinson, W.P. and Lauzon, J.L. and Innes, A.M. and Lim, K. and Arsovska, S. and McFadden, D.E.

DOI: 10.1093/humrep/del462

Fetal sex determination and disclosure,Dtermination et divulgation du sexe f"tal

Journal of Obstetrics and Gynaecology Canada

Van den Hof, M.C. and Demancziuk, N. and Bly, S. and Gagnon, R. and Lewthwaite, B. and Lim, K. and Morin, L. and Salem, S.

DOI: 10.1016/S1701-2163(16)32428-8

Intravenous immunoglobulin in antiphospholipid syndrome and maternal floor infarction when standard treatment fails: A case report

American Journal of Perinatology

Chang, P. and Millar, D. and Tsang, P. and Lim, K. and Houlihan, E. and Stephenson, M.

DOI: 10.1055/s-2006-931805

Hereditary Angioedema Managed with Low-Dose Danazol and C1 Esterase Inhibitor Concentrate: A Case Report

Journal of Obstetrics and Gynaecology Canada

Altman, A.D. and McLaughlin, J. and Schellenberg, R. and Penner, C. and Arbour, L. and Tsang, P. and Ballem, P. and Lim, K.I.

DOI: 10.1016/S1701-2163(16)32048-5

Monoamniotic twins discordant for anencephaly managed conservatively with good outcomes: Two case reports and a review of the literature

Ultrasound in Obstetrics and Gynecology

Lim, K.I. and Dy, C. and Pugash, D. and Williams, K.P.

DOI: 10.1002/uog.1947

Diagnosis of fetal ductus arteriosus aneurysm: Importance of the three-vessel view

Ultrasound in Obstetrics and Gynecology

Jackson, C.M. and Sandor, G.G.S. and Lim, K. and Duncan, W.J. and Potts, J.E.

DOI: 10.1002/uog.1927

Is the Nuchal index increased in fetuses with congenital structural heart defects?

Fetal Diagnosis and Therapy

Dahlgren, L.S. and Duncan, W.J. and Farquarhson, D.F. and Sandor, G.S. and Skoll, M.A. and Tessier, F. and Lim, K.I.

DOI: 10.1159/000089057

Fetal Soft Markers in Obstetric Ultrasound

Journal of Obstetrics and Gynaecology Canada

Van den Hof, M.C. and Wilson, R.D. and Bly, S. and Gagnon, R. and Lewthwaite, Ms.B. and Lim, K. and Morin, L. and Salem, S. and Allen, V. and Blight, C. and Davies, G. and Desilets, V. and Gagnon, A. and Reid, G. and Summers, A. and Wyatt, P. and Young, D.C.

DOI: 10.1016/S1701-2163(16)30720-4

Diagnosis and outcome of dextrocardia diagnosed in the fetus

American Journal of Cardiology

Walmsley, R. and Hishitani, T. and Sandor, G.G.S. and Lim, K. and Duncan, W. and Tessier, F. and Farquharson, D.F. and Potts, J.E.

DOI: 10.1016/j.amjcard.2004.03.049

Do commonly used oral antihypertensives alter fetal or neonatal heart rate characteristics? A systematic review

Hypertension in Pregnancy

Waterman, E.J. and Magee, L.A. and Lim, K.I. and Skoll, A. and Rurak, D. and Von Dadelszen, P.

DOI: 10.1081/PRG-120028291

Cephalic index is not a useful sonographic marker for trisomy 21 and trisomy 18

Fetal Diagnosis and Therapy

Lim, K.I. and Delisle, M.-F. and Austin, S.J. and Wilson, R.D.

DOI: 10.1159/000080161

Vaginal misoprostol induced midtrimester termination of pregnancy more quickly than oral misoprostol

Evidence-based Obstetrics and Gynecology

Bebbington, M.W. and Kent, N. and Lim, K. and Gagnon, A. and Delisle, M.R. and Tessier, F. and Wilson, R.A. and Ngai, S.W.

DOI: 10.1016/S1361-259X(03)00078-3

A randomized controlled trial comparing two protocols for the use of misoprostol in midtrimester pregnancy termination

American Journal of Obstetrics and Gynecology

Bebbington, M.W. and Kent, N. and Lim, K. and Gagnon, A. and Delisle, M.F. and Tessier, F. and Wilson, R.D.

DOI: 10.1067/mob.2002.127461

Nuchal index: A gestational age independent ultrasound marker for the detection of Down syndrome

Prenatal Diagnosis

Lim, K.I. and Pugash, D. and Dansereau, J. and Wilson, R.D.

DOI: 10.1002/pd.497

Flow-mediated vasodilation

The endothelium is an organ involved in a variety of functions: it regulates vascular tone, permeability, coagulation, inflammation and smooth muscle proliferation in order to maintain normal tissue perfusion and a quiescent vascular wall. The predominant effect at rest is thought to be maintenance of low arterial tone by the production of mediators that regulate peripheral resistance. The best-studied mediator of endothelial function is nitric oxide (NO). NO synthesis and release is stimulated by a number of circulating factors that act through specific membrane receptors and also by increased blood flow, which causes an increase in shear stress on the endothelial cell. NO diffuses into the adjacent smooth muscle cells where it increases cGMP, resulting in lowered intracellular calcium and muscular relaxation. The biological half-life of NO is about 15 seconds, allowing rapid changes in smooth muscle tone. It is thought that endothelial function is increased in pregnancy, explaining why pregnancy is associated with lower blood pressure despite a larger blood volume and cardiac output and reduced sensitivity to circulating pressors. A number of techniques have been used to assess the ability of the endothelium to regulate the lumen of blood vessels. Flow-mediated dilatation (FMD) measures endothelium­-mediated vasodilation in conduit arteries using high-resolution ultrasound of the brachial artery. This study is to examine the changes in flow-mediated vasodilation between diabetic and euglycemic pregnant women

In-utero drug administration in the fetal sheep model

The goal of in-utero fetal therapy is to improve child health by early recognition and treatment of diseases. Many conditions affecting babies prior to birth are easily diagnosed, and many are amenable to in-utero treatment. For example, some babies develop abnormally fast heart rates (super-ventricular tachycardia) while still in the mother's womb; if left untreated this will likely result in fetal death. Although the main route to administering medicine to the fetus is through the maternal blood stream (uterus/placenta), this route is sometimes unavailable or ineffective in achieving adequate drug levels if the fetus is quite ill. Also, transplacental administration of medication to the fetus exposes the mother to medication toxicity, as high drug levels in the mother are often needed to achieve therapeutic levels in a fetus. This project will explore alternative avenues for delivering medicine to babies prior to birth. We propose to compare three different methods of in-utero drug delivery of Digoxin in the fetal lamb model.

The prenatal detection of congenital heart disease

Congenital heart disease (CHD) is one of the most common birth defects. Prenatal detection allows parents to be informed about their child's condition and to arrange for delivery in a tertiary care centre with full cardiac services. There is growing evidence that outcomes in children with CHD are improved with prenatal detection and planned delivery in a specialized centre. Second trimester prenatal ultrasound has been the primary screening tool in detecting CHD. Unfortunately, the standard views imaged this way only detect 20-50% of CHD. This pilot project will answer questions about the efficacy of second trimester scanning to detect CHD and whether modification of this scan by adding several ultrasound markers of CHD will enhance the detection rate.

Grants

CIHR Operating Grant - Project: "The Canadian STRIDER Trial: sildenafil for dismal prognosis IUGR" (2014-2019)

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