Overview

The early treatment of fetal diseases in-utero may lead to improved outcomes for these babies. Integral to any early treatment program is the ability to evaluate the structure and physiology of the fetus in utero, both in normal and abnormal situations, as well as the animal models where therapies/theories can be tested prior to application in humans. My research interest attempts to meld all three areas towards the common goal of improved fetal therapy. Therefore, my research involves two main areas: prenatal ultrasound/imaging with regards to fetal diagnosis, disease and normal physiology; and the use of the fetal sheep model to investigate novel therapeutic approaches.

Publications

Dietary Aromatic Amino Acid Requirements During Early and Late Gestation in Healthy Pregnant Women.
The Journal of nutrition
Ennis MA and Ong AJ and Lim K and Ball RO and Pencharz PB and Courtney-Martin G and Elango R
DOI: 10.1093/jn/nxaa317
PubMed: 33188409
12/2020

Guideline No. 401: Sonographic Cervical Length in Singleton Pregnancies: Techniques and Clinical Applications.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Lim KI and Butt K and Nevo O and Crane JM
DOI: 10.1016/j.jogc.2019.06.002
PubMed: 33189242
11/2020

Directive clinique no 401 : Mesure échographique de la longueur du col en cas de grossesse monofœtale : Techniques et applications cliniques.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Lim KI and Butt K and Nevo O and Crane JM
DOI: 10.1016/j.jogc.2020.09.011
PubMed: 33189243
11/2020

Dietary phenylalanine requirements during early and late gestation in healthy pregnant women.
The American journal of clinical nutrition
Ennis MA and Rasmussen BF and Lim K and Ball RO and Pencharz PB and Courtney-Martin G and Elango R
DOI: 10.1093/ajcn/nqz288
PubMed: 31758682
02/2020

No 383 - Dépistage, diagnostic et prise en charge des troubles du spectre du placenta accreta.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Hobson SR and Kingdom JC and Murji A and Windrim RC and Carvalho JCA and Singh SS and Ziegler C and Birch C and Frecker E and Lim K and Cargill Y and Allen LM
DOI: 10.1016/j.jogc.2019.04.002
PubMed: 31227058
07/2019

No. 383-Screening, Diagnosis, and Management of Placenta Accreta Spectrum Disorders.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Hobson SR and Kingdom JC and Murji A and Windrim RC and Carvalho JCA and Singh SS and Ziegler C and Birch C and Frecker E and Lim K and Cargill Y and Allen LM
DOI: 10.1016/j.jogc.2018.12.004
PubMed: 31227057
07/2019

No 374 - Évaluation systématique de la longueur cervicale.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Butt K and Crane J and Hutcheon J and Lim K and Nevo O
DOI: 10.1016/j.jogc.2019.01.003
PubMed: 30784568
03/2019

No. 374-Universal Cervical Length Screening
Journal of Obstetrics and Gynaecology Canada
Butt, K. and Crane, J. and Hutcheon, J. and Lim, K. and Nevo, O.
DOI: 10.1016/j.jogc.2018.09.019
2019

Directive clinique No 388 - Détermination de l’âge gestationnel par échographie
Journal of Obstetrics and Gynaecology Canada
Butt, K. and Lim, K.I.
DOI: 10.1016/j.jogc.2019.04.011
2019

Guideline No. 388-Determination of Gestational Age by Ultrasound
Journal of Obstetrics and Gynaecology Canada
Butt, K. and Lim, K.I.
DOI: 10.1016/j.jogc.2019.04.010
2019

No. 304-Joint SOGC/CAR Policy Statement on Non-medical Use of Fetal Ultrasound
Journal of Obstetrics and Gynaecology Canada
Salem, S. and Lim, K. and Van den Hof, M.C.
DOI: 10.1016/j.jogc.2018.11.022
2019

No 304 - Déclaration de principe commune SOGC/CAR sur l'utilisation non médicale de l’échographie fœtale
Journal of Obstetrics and Gynaecology Canada
Salem, S. and Lim, K. and Van den Hof, M.C.
DOI: 10.1016/j.jogc.2018.11.023
2019

Stillbirth Associated With Birth Weight Discordance in Twin Gestations
Journal of Obstetrics and Gynaecology Canada
Jahanfar, S. and Lim, K. and Oviedo-Joekes, E.
DOI: 10.1016/j.jogc.2018.02.017
2019

Association between gestational weight gain and severe adverse birth outcomes in Washington State, US: A population-based retrospective cohort study, 2004-2013
PLoS Medicine
Vivian Ukah, U. and Bayrampour, H. and Sabr, Y. and Razaz, N. and Chan, W.-S. and Lim, K.I. and Lisonkova, S.
DOI: 10.1371/journal.pmed.1003009
2019

Temporal trends in neonatal mortality and morbidity following spontaneous and clinician-initiated preterm birth in Washington State, USA: A population-based study
BMJ Open
Richter, L.L. and Ting, J. and Muraca, G.M. and Synnes, A. and Lim, K.I. and Lisonkova, S.
DOI: 10.1136/bmjopen-2018-023004
2019

Reply
Ultrasound in Obstetrics and Gynecology
Groom, K.M. and Ganzevoort, W. and Alfirevic, Z. and Lim, K. and Papageorghiou, A.T.
DOI: 10.1002/uog.20202
2019

Association between prepregnancy body mass index and severe maternal morbidity
Obstetrical and Gynecological Survey
Lisonkova, S. and Muraca, G.M. and Potts, J. and Liauw, J. and Chan, W.-S. and Skoll, A. and Lim, K.I.
DOI: 10.1097/01.ogx.0000532197.91246.54
2018

Temporal trends in severe maternal and neonatal trauma during childbirth: A population-based observational study
BMJ Open
Wen, Q. and Muraca, G.M. and Ting, J. and Coad, S. and Lim, K.I. and Lisonkova, S.
DOI: 10.1136/bmjopen-2017-020578
2018

Placental pathology findings and birth weight discordance
Clinical and Experimental Obstetrics and Gynecology
Jahanfar, S. and Lim, K.
DOI: 10.12891/ceog3740.2018
2018

Viagra for fetal growth restriction: STRIDER Consortium replies to letter by Symonds and Budge
BMJ (Online)
Kenny, L.C. and Alfirevic, Z. and Baker, P.N. and Ganzevoort, W. and Gluud, C. and Groom, K.M. and Jakobsen, J.C. and Lim, K. and Magee, L.A. and Papageorghiou, A.T. and Von Dadelszen, P.
DOI: 10.1136/bmj.k4872
2018

Lysine requirements of healthy pregnant women are higher during late stages of gestation compared to early gestation
Journal of Nutrition
Payne, M. and Stephens, T. and Lim, K. and Ball, R.O. and Pencharz, P.B. and Elango, R.
DOI: 10.1093/jn/nxx034
2018

The STRIDER trials: ongoing research
The Lancet Child and Adolescent Health
Ganzevoort, W. and Gluud, C. and Lim, K. and Mol, B. and Groom, K.
DOI: 10.1016/S2352-4642(18)30036-1
2018

Variations from morning to afternoon of middle cerebral and umbilical artery blood flow, and fetal heart rate variability, and fetal characteristics in the normally developing fetus
Journal of Clinical Ultrasound
Avitan, T. and Sanders, A. and Brain, U. and Rurak, D. and Oberlander, T.F. and Lim, K.
DOI: 10.1002/jcu.22569
2018

No 257-Recours à l'évaluation échographique de la longueur cervicale pour prédire l'accouchement préterme dans le cadre de grossesses monofœtales
Journal of Obstetrics and Gynaecology Canada
Lim, K. and Butt, K. and Crane, J.M.
DOI: 10.1016/j.jogc.2017.11.017
2018

No. 257-Ultrasonographic Cervical Length Assessment in Predicting Preterm Birth in Singleton Pregnancies
Journal of Obstetrics and Gynaecology Canada
Lim, K. and Butt, K. and Crane, J.M.
DOI: 10.1016/j.jogc.2017.11.016
2018

Clinicians should stop prescribing sildenafil for fetal growth restriction (FGR): comment from the STRIDER Consortium
Ultrasound in Obstetrics and Gynecology
Groom, K.M. and Ganzevoort, W. and Alfirevic, Z. and Lim, K. and Papageorghiou, A.T. and Alfirevic, Z. and Ganzevoort, W. and M. Groom, K. and Lim, K. and Baker, P. and von Dadelszen, P. and Gluud, C. and Jakobsen, J. and Papageorghiou, A.T. and Kenny, L. and Magee, L. and Kariya, C. and Lee, T. and Li, L. and Pels, A.
DOI: 10.1002/uog.19186
2018

Outcomes of Selective Reduction of DCDA Twins Complicated by PV-PROM Compared with Expectant Management: A Case Series and Review of the Literature
Journal of Obstetrics and Gynaecology Canada
Lim, B. and Butler, B. and Gagnon, A. and Lim, K. and Marquette, G. and Dahlgren, L.
DOI: 10.1016/j.jogc.2017.09.015
2018

Is there a relationship between fetal sex and placental pathological characteristics in twin gestations?
BMC Pregnancy and Childbirth
Jahanfar, S. and Lim, K.
DOI: 10.1186/s12884-018-1896-9
2018

STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials.
BMC pregnancy and childbirth
Pels A and Kenny LC and Alfirevic Z and Baker PN and von Dadelszen P and Gluud C and Kariya CT and Mol BW and Papageorghiou AT and van Wassenaer-Leemhuis AG and Ganzevoort W and international STRIDER Consortium
DOI: 10.1186/s12884-017-1594-z
PubMed: 29282009
12/2017

Association between prepregnancy body mass index and severe maternal morbidity
JAMA - Journal of the American Medical Association
Lisonkova, S. and Muraca, G.M. and Potts, J. and Liauw, J. and Chan, W.-S. and Skoll, A. and Lim, K.I.
DOI: 10.1001/jama.2017.16191
2017

Amniotic Fluid: Technical Update on Physiology and Measurement
Journal of Obstetrics and Gynaecology Canada
Lim, K.I. and Butt, K. and Naud, K. and Smithies, M.
DOI: 10.1016/j.jogc.2016.09.012
2017

Rationale and recommendations for improving definitions, registration requirements and procedures related to fetal death and stillbirth
BJOG: An International Journal of Obstetrics and Gynaecology
Joseph, K.S. and Basso, M. and Davies, C. and Lee, L. and Ellwood, D. and Fell, D.B. and Fowler, D. and Kinniburgh, B. and Kramer, M.S. and Lim, K. and Selke, P. and Shaw, D. and Sneddon, A. and Sprague, A. and Williams, K.
DOI: 10.1111/1471-0528.14242
2017

Birth weight discordance and adverse perinatal outcomes
Journal of Perinatal Medicine
Jahanfar, S. and Lim, K. and Ovideo-Joekes, E.
DOI: 10.1515/jpm-2016-0089
2017

Adverse maternal outcomes and birth weight discordance in twin gestation: British Columbia, Canadian data
International Journal of Women's Health
Jahanfar, S. and Lim, K.
DOI: 10.2147/IJWH.S115515
2017

Gadolinium magnetic resonance imaging during pregnancy associated with adverse neonatal and post-neonatal outcomes
Journal of Pediatrics
Potts, J. and Lisonkova, S. and Murphy, D.T. and Lim, K.
DOI: 10.1016/j.jpeds.2016.10.061
2017

No 352 – Mise à jour technique: Le rôle de l'examen échographique précoce et exhaustif de l'anatomie fœtale
Journal of Obstetrics and Gynaecology Canada
Nevo, O. and Brown, R. and Glanc, P. and Lim, K.
DOI: 10.1016/j.jogc.2017.09.009
2017

No. 352-Technical Update: The Role of Early Comprehensive Fetal Anatomy Ultrasound Examination
Journal of Obstetrics and Gynaecology Canada
Nevo, O. and Brown, R. and Glanc, P. and Lim, K.
DOI: 10.1016/j.jogc.2017.06.031
2017

Mise à jour technique sur la physiologie et l’évaluation du liquide amniotique
Journal of Obstetrics and Gynaecology Canada
Lim, K.I. and Butt, K. and Naud, K. and Smithies, M.
DOI: 10.1016/j.jogc.2016.12.001
2017

N° 260-Échographie et grossesse gémellaire
Journal of Obstetrics and Gynaecology Canada
Morin, L. and Lim, K.
DOI: 10.1016/j.jogc.2017.08.019
2017

No. 260-Ultrasound in Twin Pregnancies
Journal of Obstetrics and Gynaecology Canada
Morin, L. and Lim, K.
DOI: 10.1016/j.jogc.2017.08.014
2017

Maternal morbidity and perinatal outcomes among women in rural versus urban areas
CMAJ
Lisonkova, S. and Haslam, M.D. and Dahlgren, L. and Chen, I. and Synnes, A.R. and Lim, K.I.
DOI: 10.1503/cmaj.151382
2016

Determination of Gestational Age by Ultrasound: In Response
Journal of Obstetrics and Gynaecology Canada
Butt, K. and Lim, K.
DOI: 10.1016/j.jogc.2016.04.003
2016

Optimal threshold for birth weight discordance: Does knowledge of chorionicity matter?
Journal of Perinatology
Jahanfar, S. and Lim, K. and Oviedo-Joekes, E.
DOI: 10.1038/jp.2016.82
2016

Utilisation de l'imagerie par résonance magnétique en obstétrique
Journal of Obstetrics and Gynaecology Canada
Patenaude, Y. and Pugash, D. and Lim, K. and Morin, L.
DOI: 10.1016/j.jogc.2016.09.051
2016

Déclaration de principe commune SOGC/CAR sur l'utilisation non médicale de l’échographie fœtal
Journal of Obstetrics and Gynaecology Canada
Salem, S. and Lim, K. and Van den Hof, M.C.
DOI: 10.1016/j.jogc.2016.09.049
2016

Détermination de l'âge gestationnel par échographie
Journal of Obstetrics and Gynaecology Canada
Butt, K. and Lim, K.
DOI: 10.1016/j.jogc.2016.09.048
2016

The authors respond
CMAJ
Lisonkova, S. and Lim, K.I. and Synnes, A.R.
DOI: 10.1503/cmaj.1150132
2016

Effect of folic acid food fortification in Canada on congenital heart disease subtypes
Circulation
Liu, S. and Joseph, K.S. and Luo, W. and León, J.A. and Lisonkova, S. and Van Den Hof, M. and Evans, J. and Lim, K. and Little, J. and Sauve, R. and Kramer, M.S.
DOI: 10.1161/CIRCULATIONAHA.116.022126
2016

The Impact of Gender on Anthropometric Measures of Twins
Twin Research and Human Genetics
Jahanfar, S. and Lim, K.
DOI: 10.1017/thg.2016.57
2016

Evaluation of the International Association of the Diabetes in Pregnancy Study Group New Criteria: Gestational Diabetes Project
Canadian Journal of Diabetes
Kong, J.M. and Lim, K. and Thompson, D.M.
DOI: 10.1016/j.jcjd.2014.09.007
2015

The impact of maternal positive and negative affect on fetal physiology and diurnal patterns
Israel Journal of Psychiatry and Related Sciences
Hanley, G.E. and Rurak, D. and Lim, K. and Brain, U. and Oberlander, T.F.
2014

The use of magnetic resonance imaging in the obstetric patient,Utilisation de l'imagerie par résonance magnétique en obstétrique
Journal of Obstetrics and Gynaecology Canada
Patenaude, Y. and Pugash, D. and Lim, K. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Naud, K. and Ouellet, A. and Salem, S.
DOI: 10.1016/S1701-2163(15)30613-7
2014

Joint SOGC/CAR Policy Statement on Non-medical Use of Fetal Ultrasound
Journal of Obstetrics and Gynaecology Canada
Salem, S. and Lim, K. and Harris, A. and Van den Hof, M.C. and Naud, K. and Keough, V. and Bly, S. and Cargill, Y. and O'Sullivan, J. and Butt, K. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Vickar, D. and Lautner, D. and Patenaude, Y.
DOI: 10.1016/S1701-2163(15)30666-6
2014

Determination of Gestational Age by Ultrasound
Journal of Obstetrics and Gynaecology Canada
Butt, K. and Lim, K. and Bly, S. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Salem, S.
DOI: 10.1016/S1701-2163(15)30664-2
2014

The Use of Magnetic Resonance Imaging in the Obstetric Patient
Journal of Obstetrics and Gynaecology Canada
Patenaude, Y. and Pugash, D. and Lim, K. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Naud, K. and Ouellet, A. and Salem, S.
DOI: 10.1016/S1701-2163(15)30612-5
2014

A SYSTEMATIC REVIEW of BIRTH WEIGHT DISCORDANCE and PERINATAL OUTCOMES
Fetal and Maternal Medicine Review
Jahanfar, S. and Lim, K.
DOI: 10.1017/S0965539516000012
2014

Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes
Diabetologia
Kallas-Koeman, M.M. and Kong, J.M. and Klinke, J.A. and Butalia, S. and Lodha, A.K. and Lim, K.I. and Duan, Q.M. and Donovan, L.E.
DOI: 10.1007/s00125-014-3163-6
2014

Joint SOGC/CAR policy statement on non-medical use of fetal ultrasound,Déclaration de principe commune SOGC/CAR sur l'utilisation non médicale de l'échographie foetale
Journal of Obstetrics and Gynaecology Canada
Salem, S. and Lim, K. and Harris, A. and Van den Hof, M.C. and Keough, V. and Naud, K. and Bly, S. and Cargill, Y. and O'Sullivan, J. and Butt, K. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Vickar, D. and Lautner, D. and Patenaude, Y.
DOI: 10.1016/S1701-2163(15)30667-8
2014

Determination of gestational age by ultrasound,Détermination de l'âge gestationnel par échographie
Journal of Obstetrics and Gynaecology Canada
Butt, K. and Lim, K. and Bly, S. and Cargill, Y. and Davies, G. and Denis, N. and Hazlitt, G. and Morin, L. and Ouellet, A. and Salem, S.
DOI: 10.1016/S1701-2163(15)30665-4
2014

The effect of hyperinsulinemia and hyperglycemia on endothelial function in pregnant patients with type-2 diabetes
Diabetes Research and Clinical Practice
Khurana, R. and Meneilly, G.S. and Lim, K. and Thompson, D.
DOI: 10.1016/j.diabres.2013.12.053
2014

Immortal time bias in the study of stillbirth risk factors: The example of gestational diabetes
Epidemiology
Hutcheon, J.A. and Kuret, V. and Joseph, K.S. and Sabr, Y. and Lim, K.
DOI: 10.1097/EDE.0b013e3182a6d9aa
2013

An assessment of predictive value of the biophysical profile in women with preeclampsia using data from the fullPIERS database
Pregnancy Hypertension
Payne, B.A. and Kyle, P.M. and Lim, K. and Lisonkova, S. and Magee, L.A. and Pullar, B. and Qu, Z. and Von Dadelszen, P.
DOI: 10.1016/j.preghy.2013.03.001
2013

The Case for Universal Cervical Length Screening to Prevent Preterm Birth: Is it Strong Enough to Change Practice in Canada?
Journal of Obstetrics and Gynaecology Canada
Hutcheon, J.A. and Amanda Skoll, M. and Eastabrook, G.D. and Lim, K.I. and on behalf of the University of British Columbia Division of Maternal-Fetal Medicine
DOI: 10.1016/S1701-2163(16)35467-6
2012

Reversed umbilical arterial end diastolic flow, sildenafil treatment and early stillbirths
BJOG: An International Journal of Obstetrics and Gynaecology
Von Dadelszen, P. and Lim, K.I. and Dwinnell, S. and Magee, L.A. and Carleton, B.C. and Gruslin, A. and Lee, B. and Liston, R.M. and Miller, S.P. and Rurak, D. and Sherlock, R.L. and Skoll, M.A. and Wareing, M.M. and Baker, P.N.
DOI: 10.1111/j.1471-0528.2011.03263.x
2012

Population-based review of tetralogy of Fallot with absent pulmonary valve: Is prenatal diagnosis really associated with a poor prognosis?
Ultrasound in Obstetrics and Gynecology
Mivelaz, Y. and Lim, K.I. and Templeton, C. and Campbell, A.I. and Potts, J.E. and Sandor, G.G.S.
DOI: 10.1002/uog.11126
2012

Third trimester fetal pulmonary artery Doppler blood flow velocity characteristics following prenatal selective serotonin reuptake inhibitor (SSRI) exposure
Early Human Development
Lim, K. and Sanders, A. and Brain, U. and Riggs, W. and Oberlander, T.F. and Rurak, D.
DOI: 10.1016/j.earlhumdev.2012.01.004
2012

Prediction of pediatric outcome after prenatal diagnosis and expectant antenatal management of congenital cystic adenomatoid malformation
Fetal Diagnosis and Therapy
Yong, P.J. and Von Dadelszen, P. and Carpara, D. and Lim, K. and Kent, N. and Tessier, F. and Delisle, M.-F. and Wong, T. and Blair, G. and Skarsgard, E.D.
DOI: 10.1159/000331936
2012

Échographie et grossesse gémellaire
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/s1701-2163(16)34917-9
06/2011

Ultrasound in Twin Pregnancies
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/s1701-2163(16)34916-7
06/2011

Ultrasonographic Cervical Length Assessment in Predicting Preterm Birth in Singleton Pregnancies
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/s1701-2163(16)34884-8
05/2011

Recours à l’évaluation échographique de la longueur cervicale pour prédire l’accouchement préterme dans le cadre de grossesses monofœtales
Journal of Obstetrics and Gynaecology Canada
DOI: 10.1016/s1701-2163(16)34885-x
05/2011

Sildenafil citrate therapy for severe early-onset intrauterine growth restriction
BJOG: An International Journal of Obstetrics and Gynaecology
Von Dadelszen, P. and Dwinnell, S. and Magee, L.A. and Carleton, B.C. and Gruslin, A. and Lee, B. and Lim, K.I. and Liston, R.M. and Miller, S.P. and Rurak, D. and Sherlock, R.L. and Skoll, M.A. and Wareing, M.M. and Baker, P.N.
DOI: 10.1111/j.1471-0528.2010.02879.x
2011

Third trimester fetal heart rate and doppler middle cerebral artery blood flow velocity characteristics during prenatal selective serotonin reuptake inhibitor exposure
Pediatric Research
Rurak, D. and Lim, K. and Sanders, A. and Brain, U. and Riggs, W. and Oberlander, T.F.
DOI: 10.1203/PDR.0b013e31821ba11a
2011

Initial Evaluation and Referral Guidelines for Management of Pelvic/Ovarian Masses
Journal of Obstetrics and Gynaecology Canada
Le, T. and Giede, C. and Salem, S. and Lefebvre, G. and Rosen, B. and Bentley, J. and Kupets, R. and Power, P. and Renaud, M.-C. and Bryson, P. and Davis, D.B. and Lau, S. and Lotocki, R. and Senikas, V. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Gagnon, R. and Anne Hietala-Coyle, M. and Lim, K.I. and Ouellet, A. and Racicot, M.-H.
DOI: 10.1016/S1701-2163(16)34254-2
2009

Guidelines for the management of vasa previa,Directive clinique sur la prise en charge du vasa praevia
Journal of Obstetrics and Gynaecology Canada
Gagnon, R. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Hietala-Coyle, M.A. and Lim, K.I. and Ouellet, A. and Racicot, M. and Salem, S. and Hudon, L. and Basso, M. and Bos, H. and Delisle, M.-F. and Farine, D. and Grabowska, K. and Menticoglou, S. and Mundle, W. and Murphy-Kaulbeck, L. and Pressey, T. and Roggensack, A.
DOI: 10.1016/S1701-2163(16)34283-9
2009

Initial evaluation and referral guidelines for management of pelvic/ovarian masses,Prise en charge des masses pelviennes/ovariennes: Évaluation initiale et lignes directrices quant à l'orientation des patientes
Journal of Obstetrics and Gynaecology Canada
Le, T. and Giede, C. and Salem, S. and Lefebvre, G. and Rosen, B. and Bentley, J. and Kupets, R. and Power, P. and Renaud, M.-C. and Bryson, P. and Davis, D.B. and Lau, S. and Lotocki, R. and Senikas, V. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Gagnon, R. and Hietala-Coyle, M.A. and Lim, K.I. and Ouellet, A. and Racicot, M.-H.
DOI: 10.1016/S1701-2163(16)34255-4
2009

Content of a Complete Routine Second Trimester Obstetrical Ultrasound Examination and Report
Journal of Obstetrics and Gynaecology Canada
Cargill, Y. and Morin, L. and Bly, S. and Butt, K. and Denis, N. and Gagnon, R. and Hietala-Coyle, M.A. and Lim, K. and Ouellet, A. and Racicot, M.-H. and Salem, S.
DOI: 10.1016/S1701-2163(16)34127-5
2009

Guidelines for the Management of Vasa Previa
Journal of Obstetrics and Gynaecology Canada
Gagnon, R. and Morin, L. and Bly, S. and Butt, K. and Cargill, Y.M. and Denis, N. and Anne Hietala-Coyle, M. and Lim, K.I. and Ouellet, A. and Racicot, M.-H. and Salem, S. and Hudon, L. and Basso, M. and Bos, H. and Delisle, M.-F. and Farine, D. and Grabowska, K. and Menticoglou, S. and Mundle, W. and Murphy-Kaulbeck, L. and Pressey, T. and Roggensack, A.
DOI: 10.1016/S1701-2163(16)34282-7
2009

Content of a complete routine second trimester obstetrical ultrasound examination and report,Tenue systématique d'un examen échographique obstétrical au cours du deuxième trimestre: Contenu d'un examen et d'un rapport exhaustifs
Journal of Obstetrics and Gynaecology Canada
Cargill, Y. and Morin, L. and Bly, S. and Butt, K. and Denis, N. and Gagnon, R. and Hietala-Coyle, M.A. and Lim, K. and Ouellet, A. and Racicot, M.-H. and Salem, S.
DOI: 10.1016/S1701-2163(16)34128-7
2009

Fetal sex determination and disclosure,Détermination et divulgation du sexe fœtal
Journal of Obstetrics and Gynaecology Canada
Van den Hof, M.C. and Demancziuk, N. and Bly, S. and Gagnon, R. and Lewthwaite, B. and Lim, K. and Morin, L. and Salem, S.
DOI: 10.1016/S1701-2163(16)32428-8
2007

Non-medical use of fetal ultrasound,Utilisation non médicale de l'échographie fœtale
Journal of Obstetrics and Gynaecology Canada
Van den Hof, M.C. and Bly, S. and Gagnon, R. and Lewthwaite, B. and Lim, K. and Morin, L. and Salem, S.
DOI: 10.1016/S1701-2163(16)32427-6
2007

Origin and outcome of pregnancies affected by androgenetic/biparental chimerism
Human Reproduction
Robinson, W.P. and Lauzon, J.L. and Innes, A.M. and Lim, K. and Arsovska, S. and McFadden, D.E.
DOI: 10.1093/humrep/del462
2007

Hereditary Angioedema Managed with Low-Dose Danazol and C1 Esterase Inhibitor Concentrate: A Case Report
Journal of Obstetrics and Gynaecology Canada
Altman, A.D. and McLaughlin, J. and Schellenberg, R. and Penner, C. and Arbour, L. and Tsang, P. and Ballem, P. and Lim, K.I.
DOI: 10.1016/S1701-2163(16)32048-5
2006

Intravenous immunoglobulin in antiphospholipid syndrome and maternal floor infarction when standard treatment fails: A case report
American Journal of Perinatology
Chang, P. and Millar, D. and Tsang, P. and Lim, K. and Houlihan, E. and Stephenson, M.
DOI: 10.1055/s-2006-931805
2006

Is the Nuchal index increased in fetuses with congenital structural heart defects?
Fetal Diagnosis and Therapy
Dahlgren, L.S. and Duncan, W.J. and Farquarhson, D.F. and Sandor, G.S. and Skoll, M.A. and Tessier, F. and Lim, K.I.
DOI: 10.1159/000089057
2005

Monoamniotic twins discordant for anencephaly managed conservatively with good outcomes: Two case reports and a review of the literature
Ultrasound in Obstetrics and Gynecology
Lim, K.I. and Dy, C. and Pugash, D. and Williams, K.P.
DOI: 10.1002/uog.1947
2005

Diagnosis of fetal ductus arteriosus aneurysm: Importance of the three-vessel view
Ultrasound in Obstetrics and Gynecology
Jackson, C.M. and Sandor, G.G.S. and Lim, K. and Duncan, W.J. and Potts, J.E.
DOI: 10.1002/uog.1927
2005

Fetal Soft Markers in Obstetric Ultrasound
Journal of Obstetrics and Gynaecology Canada
Van den Hof, M.C. and Wilson, R.D. and Bly, S. and Gagnon, R. and Lewthwaite, Ms.B. and Lim, K. and Morin, L. and Salem, S. and Allen, V. and Blight, C. and Davies, G. and Desilets, V. and Gagnon, A. and Reid, G. and Summers, A. and Wyatt, P. and Young, D.C.
DOI: 10.1016/S1701-2163(16)30720-4
2005

Cephalic index is not a useful sonographic marker for trisomy 21 and trisomy 18
Fetal Diagnosis and Therapy
Lim, K.I. and Delisle, M.-F. and Austin, S.J. and Wilson, R.D.
DOI: 10.1159/000080161
2004

Diagnosis and outcome of dextrocardia diagnosed in the fetus
American Journal of Cardiology
Walmsley, R. and Hishitani, T. and Sandor, G.G.S. and Lim, K. and Duncan, W. and Tessier, F. and Farquharson, D.F. and Potts, J.E.
DOI: 10.1016/j.amjcard.2004.03.049
2004

Do commonly used oral antihypertensives alter fetal or neonatal heart rate characteristics? A systematic review
Hypertension in Pregnancy
Waterman, E.J. and Magee, L.A. and Lim, K.I. and Skoll, A. and Rurak, D. and Von Dadelszen, P.
DOI: 10.1081/PRG-120028291
2004

Vaginal misoprostol induced midtrimester termination of pregnancy more quickly than oral misoprostol
Evidence-based Obstetrics and Gynecology
Bebbington, M.W. and Kent, N. and Lim, K. and Gagnon, A. and Delisle, M.R. and Tessier, F. and Wilson, R.A. and Ngai, S.W.
DOI: 10.1016/S1361-259X(03)00078-3
2003

Nuchal index: A gestational age independent ultrasound marker for the detection of Down syndrome
Prenatal Diagnosis
Lim, K.I. and Pugash, D. and Dansereau, J. and Wilson, R.D.
DOI: 10.1002/pd.497
2002

A randomized controlled trial comparing two protocols for the use of misoprostol in midtrimester pregnancy termination
American Journal of Obstetrics and Gynecology
Bebbington, M.W. and Kent, N. and Lim, K. and Gagnon, A. and Delisle, M.F. and Tessier, F. and Wilson, R.D.
DOI: 10.1067/mob.2002.127461
2002

Research

Flow-mediated vasodilation
The endothelium is an organ involved in a variety of functions: it regulates vascular tone, permeability, coagulation, inflammation and smooth muscle proliferation in order to maintain normal tissue perfusion and a quiescent vascular wall. The predominant effect at rest is thought to be maintenance of low arterial tone by the production of mediators that regulate peripheral resistance. The best-studied mediator of endothelial function is nitric oxide (NO). NO synthesis and release is stimulated by a number of circulating factors that act through specific membrane receptors and also by increased blood flow, which causes an increase in shear stress on the endothelial cell. NO diffuses into the adjacent smooth muscle cells where it increases cGMP, resulting in lowered intracellular calcium and muscular relaxation. The biological half-life of NO is about 15 seconds, allowing rapid changes in smooth muscle tone. It is thought that endothelial function is increased in pregnancy, explaining why pregnancy is associated with lower blood pressure despite a larger blood volume and cardiac output and reduced sensitivity to circulating pressors. A number of techniques have been used to assess the ability of the endothelium to regulate the lumen of blood vessels. Flow-mediated dilatation (FMD) measures endothelium­-mediated vasodilation in conduit arteries using high-resolution ultrasound of the brachial artery. This study is to examine the changes in flow-mediated vasodilation between diabetic and euglycemic pregnant women

In-utero drug administration in the fetal sheep model
The goal of in-utero fetal therapy is to improve child health by early recognition and treatment of diseases. Many conditions affecting babies prior to birth are easily diagnosed, and many are amenable to in-utero treatment. For example, some babies develop abnormally fast heart rates (super-ventricular tachycardia) while still in the mother's womb; if left untreated this will likely result in fetal death. Although the main route to administering medicine to the fetus is through the maternal blood stream (uterus/placenta), this route is sometimes unavailable or ineffective in achieving adequate drug levels if the fetus is quite ill. Also, transplacental administration of medication to the fetus exposes the mother to medication toxicity, as high drug levels in the mother are often needed to achieve therapeutic levels in a fetus. This project will explore alternative avenues for delivering medicine to babies prior to birth. We propose to compare three different methods of in-utero drug delivery of Digoxin in the fetal lamb model.

The prenatal detection of congenital heart disease
Congenital heart disease (CHD) is one of the most common birth defects. Prenatal detection allows parents to be informed about their child's condition and to arrange for delivery in a tertiary care centre with full cardiac services. There is growing evidence that outcomes in children with CHD are improved with prenatal detection and planned delivery in a specialized centre. Second trimester prenatal ultrasound has been the primary screening tool in detecting CHD. Unfortunately, the standard views imaged this way only detect 20-50% of CHD. This pilot project will answer questions about the efficacy of second trimester scanning to detect CHD and whether modification of this scan by adding several ultrasound markers of CHD will enhance the detection rate.

Grants

CIHR Operating Grant - Project: "The Canadian STRIDER Trial: sildenafil for dismal prognosis IUGR" (2014-2019)

Research Group Members

Youkee Chung, Research Coordinator
Mohamed Elgendi
Daria Hutchinson
Larry Li, Database Manager