Kirk Schultz

MD

Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital
Director, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital
Lead, Childhood Cancer & Blood Research Group, BC Children's Hospital

We are attempting to harness the immune system to cure child leukemia and to use blood-derived stem cells to cure other life threatening childhood diseases.

Currently, blood and marrow transplantation (BMT) is the only successful form of immune therapy for childhood leukemia. Our research group focuses on harnessing the immune forces unleashed by BMT to improve immune therapy for childhood leukemia. By increasing our understanding of these important immune forces, we hope to also improve the ability to provide safe tissue transplants when needed. Lastly, our group is focused on developing approaches to extend the ability to use blood-derived stem cells to regenerate damaged tissues, correct the immune system, and save children and adolescents from life threatening childhood diseases.

Academic Affiliations

  • Professor, Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Childhood Cancer and Blood Research; Immunity in Health and Disease; Rare Diseases

Contact Information

Location

950 West 28th Ave, Vancouver, BC, Canada, V5Z 4H4

Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant

Journal of Clinical Oncology

Nicole Liberio and Mariam Allbee-Johnson and Kwang Woo Ahn and Amy Moskop and Rachel Phelan and Bronwen E. Shaw and Kristin M. Page and Kirk R. Schultz and Christine L. Phillips and Parinda A. Mehta and Muna Qayed and Akshay Sharma and Amanda E. Lipsitt and Heather Symons and Javier Bolaos-Meade and Sandhya Kharbanda and Christopher C. Dvorak and Neena Kapoor and Erin E. Doherty and Rishikesh S. Chavan and Larisa Broglie

DOI: 10.1200/JCO-25-01591

02 / 2026

Toward Better Response Assessment of Cutaneous Chronic Graft-Versus-Host Disease: A Report from the National Institutes of Health Consensus Project Task Force

Transplantation and Cellular Therapy

Alina Markova and Stephanie J. Lee and Badri Modi and Emily Baumrin and Rachel K. Rosenstein and Eric R. Tkaczyk and Julia S. Lehman and Yoshihiro Inamoto and Paul A. Carpenter and Kirk R. Schultz and Joseph A. Pidala and Paul Martin and Iskra Pusic and Sencer Goklemez and Christian Stockmann and Iago Pinal-Fernandez and Sophie Paczesny and Andrew Harris and Doris M. Ponce and Noa G. Holtzman and Najla El Jurdi and Steven Z. Pavletic and Edward W. Cowen

DOI: 10.1016/j.jtct.2026.01.009

01 / 2026

Toward Better and More Effective Clinical Trials for Chronic Graft-Versus-Host Disease

Transplantation and Cellular Therapy

Daniel Wolff and Corey Cutler and Iveta Mercep and Thomas Jaki and David S. Robertson and Kirk R. Schultz and Stephanie J. Lee and Paul J. Martin and Steven Z. Pavletic

DOI: 10.1016/j.jtct.2025.11.008

11 / 2025

Monitoring for paediatric pulmonary graft versus host disease with multiple breath washout

ERJ Open Research

Britney X. Ha and Juliana P. Roden and Rodrigo A. Sandoval and Kirk R. Schultz and Jonathan H. Rayment

DOI: 10.1183/23120541.00015-2025

09 / 2025

Expansion and characterization of immune suppressive CD56(bright)Perforin(-) regulatory-like natural killer cells in chronic graft-versus-host disease

Cytotherapy

Madeline P. Lauener and Erin Tanaka and Ao Mei and Sayeh Abdossamadi and Elena Ostroumov and Ramon I. Klein Geltink and Subra Malarkannan and Kirk R. Schultz

DOI: 10.1016/j.jcyt.2024.07.013

12 / 2024

Diagnosis of Post-Hematopoietic Stem Cell Transplantation Bronchiolitis Obliterans Syndrome in Children: Time for a Rethink?

Transplantation and Cellular Therapy

Shivanthan Shanthikumar and William A. Gower and Kenneth R. Cooke and Anne Bergeron and Kirk R. Schultz and Amisha Barochia and Maximiliano Tamae-Kakazu and Edward Charbek and Erin E. Reardon and Charlotte Calvo and Alicia Casey and Pi Chun Cheng and Theresa S. Cole and Stella M. Davies and Shailendra Das and Alive De and Robin R. Deterding and Deborah R. Liptzin and Francoise Mechinaud and Jonathan H. Rayment and Paul D. Robinson and Roopa Siddaiah and Anne Stone and Saumini Srinivasin and Christopher T. Towe and Gregory A. Yanik and Narayan P. Iyer and Samuel B. Goldfarb

DOI: 10.1016/j.jtct.2024.05.012

08 / 2024

Tubular Injury Biomarkers to Predict CKD and Hypertension at 3 Months Post-Cisplatin in Children

Kidney360

Ryan S. Huang and Kelly R. McMahon and Stella Wang and Hayton Chui and Asaf Lebel and Jasmine Lee and Vedran Cockovski and Shahrad Rod Rassekh and Kirk R. Schultz and Tom D. Blydt-Hansen and Geoffrey D.E. Cuvelier and Cherry Mammen and Maury Pinsk and Bruce C. Carleton and Ross T. Tsuyuki and Colin J.D. Ross and Ana Palijan and Michael Zappitelli

DOI: 10.34067/KID.0000000000000448

06 / 2024

The Onset of Puberty Presents Unique Management Issues in Penile Chronic Graft-versus-Host Disease Requiring Circumcision in Male Pediatric Patients

Pediatric Hematology and Oncology

Chia Huan Ng and Juliana P. Roden and Jefferson Terry and Kirk R. Schultz

DOI: 10.1080/08880018.2023.2277765

05 / 2024

Circulating cell-free mitochondrial DNA as a diagnostic and prognostic biomarker in chronic and late acute graft-versus-host disease in children

Experimental Hematology

Shima Azadpour and Sayeh Abdossamadi and Bernard Ng and Elena Ostroumov and Saeid Abroun and Geoffrey D.E. Cuvelier and Kirk R. Schultz

DOI: 10.1016/j.exphem.2023.02.004

05 / 2023

Elevated ADA2 Enzyme Activity at the Onset of Chronic Graft-versus-Host Disease in Children

Transplantation and Cellular Therapy

Sarah M. Bowers and Bernard Ng and Sayeh Abdossamadi and Amina Kariminia and David A. Cabral and Geoffrey D.E. Cuvelier and Kirk R. Schultz and Kelly L. Brown

DOI: 10.1016/j.jtct.2023.02.014

05 / 2023

Chronic gvhd dictionary"eurograft cost action initiative consensus report

Bone Marrow Transplantation

Ana Zelic Kerep and Atillio Olivieri and Helene Schoemans and Anita Lawitschka and Jrg Halter and Drazen Pulanic and Anne Dickinson and Hildegard T. Greinix and Steven Z. Pavletic and Kirk R. Schultz and Stephanie J. Lee and Daniel Wolff

DOI: 10.1038/s41409-022-01837-w

01 / 2023

Ibrutinib Treatment of Pediatric Chronic Graft-versus-Host Disease: Primary Results from the Phase 1/2 iMAGINE Study

Transplantation and Cellular Therapy

Paul A. Carpenter and Hyoung Jin Kang and Keon Hee Yoo and Marco Zecca and Bin Cho and Giovanna Lucchini and Eneida R. Nemecek and Kirk R. Schultz and Polina Stepensky and Sonali Chaudhury and Benjamin Oshrine and Seong Lin Khaw and Andrew C. Harris and Marta Verna and Liudmila Zubarovskaya and Yihua Lee and Justin Wahlstrom and Lori Styles and Peter J. Shaw and Jean-Hugues Dalle

DOI: 10.1016/j.jtct.2022.08.021

11 / 2022

Multiple Breath Washout Testing to Identify Pulmonary Chronic Graft Versus Host Disease in Children After Hematopoietic Stem Cell Transplantation

Transplantation and Cellular Therapy

Jonathan H. Rayment and Rodrigo A. Sandoval and Juliana P. Roden and Kirk R. Schultz

DOI: 10.1016/j.jtct.2022.02.002

06 / 2022

Successful rescue transplant for children with primary graft failure using early intervention with a single day preparative regimen and related haploidentical donor

Bone Marrow Transplantation

Divya Subburaj and Amanda M. Li and Jacob Rozmus and Kirk R. Schultz

DOI: 10.1038/s41409-021-01309-7

08 / 2021

Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies

Blood

Kirk R. Schultz and Amina Kariminia and Bernard Ng and Sayeh Abdossamadi and Madeline Lauener and Eneida R. Nemecek and Justin T. Wahlstrom and Carrie L. Kitko and Victor A. Lewis and Tal Schechter and David A. Jacobsohn and Andrew C. Harris and Michael A. Pulsipher and Henrique Bittencourt and Sung Won Choi and Emi H. Caywood and Kimberly A. Kasow and Monica Bhatia and Benjamin R. Oshrine and Allyson Flower and Sonali Chaudhury and Donald Coulter and Joseph H. Chewning and Michael Joyce and Sureyya Savasan and Anna B. Pawlowska and Gail C. Megason and David Mitchell and Alexandra C. Cheerva and Anita Lawitschka and Shima Azadpour and Elena Ostroumov and Peter Subrt and Anat Halevy and Sara Mostafavi and Geoffrey D. E. Cuvelier

DOI: 10.1182/blood.2019003186

04 / 2020

Access to Hematopoietic Stem Cell Transplantation among Pediatric Patients with Acute Lymphoblastic Leukemia: A Population-Based Analysis

Biology of Blood and Marrow Transplantation

Tony H. Truong and Jason D. Pole and Henrique Bittencourt and Tal Schechter and Geoff D.E. Cuvelier and Kristjan Paulson and Meera Rayar and David Mitchell and Kirk R. Schultz and Debbie O'Shea and Randy Barber and Donna Wall and Lillian Sung

DOI: 10.1016/j.bbmt.2019.02.009

06 / 2019

Comprehensive B Cell Phenotyping Profile for Chronic Graft-versus-Host Disease Diagnosis

Biology of Blood and Marrow Transplantation

Jacob Rozmus and Amina Kariminia and Sayeh Abdossamadi and Barry E. Storer and Paul J. Martin and Stephanie J. Lee and Daniel Wolff and Mukta Arora and Corey Cutler and Kirk R. Schultz

DOI: 10.1016/j.bbmt.2018.11.007

03 / 2019

The case for plerixafor to replace filgrastim as the optimal agent to mobilize peripheral blood donors for allogeneic hematopoietic cell transplantation

Experimental Hematology

Stephen Couban and Peggy C. Wong and Kirk R. Schultz

DOI: 10.1016/j.exphem.2018.11.003

02 / 2019

EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment

Bone Marrow Transplantation

Helene M. Schoemans and Stephanie J. Lee and James L. Ferrara and Daniel Wolff and John E. Levine and Kirk R. Schultz and Bronwen E. Shaw and Mary E. Flowers and Tapani Ruutu and Hildegard Greinix and Ernst Holler and Grzegorz Basak and Rafael F. Duarte and Steven Z. Pavletic

DOI: 10.1038/s41409-018-0204-7

11 / 2018

Influence of Age on Acute and Chronic GVHD in Children Receiving HLA-Identical Sibling BMT for Acute Leukemia: Implications for Prophylaxis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

DOI: 10.1016/j.bbmt.2017.11.004 PubMed: 29155316

11 / 2017

Umbilical Cord Blood Transplantation in Children with Acute Leukemia: Impact of Conditioning on Transplantation Outcomes.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

DOI: 10.1016/j.bbmt.2017.06.023 PubMed: 28684372

07 / 2017

New answers to old conundrums: what antibodies, exosomes and inflammasomes bring to the conversation. Canadian National Transplant Research Program international summit report.

Transplantation

DOI: 10.1097/tp.0000000000001872 PubMed: 28731910

07 / 2017

Outcome of Hematopoietic Cell Transplantation for DNA-Double Strand Breakage Repair Disorders.

Slack J and Albert MH and Balashov D and Belohradsky BH and Bertaina A and Bleesing J and Booth C and Bchner J and Buckley RH and Ouache-Chardin M and Deripapa E and Drabko K and Eapen M and Feuchtinger T and Finocchi A and Gaspar HB and Ghosh S and Gillio A and Gonzalez-Granado LI and Grunebaum E

DOI: 10.1016/j.jaci.2017.02.036 PubMed: 28392333

04 / 2017

Erratum to "Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study" [Biol Blood Marrow Transplant 2016;22:1410-1415].

Couban S and Aljurf M and Lachance S and Walker I and Toze C and Rubinger M and Lipton JH and Lee SJ and Szer J and Doocey R and Lewis ID and Huebsch L and Howson-Jan K and Lalancette M and Almohareb F and Chaudhri N and Ivison S and Broady R and Levings M and Fairclough D

DOI: 10.1016/j.bbmt.2016.09.021 PubMed: 27789277

03 / 2017

Improved survival after acute graft vs host disease diagnosis in the modern era.

Khoury HJ and Wang T and Hemmer MT and Couriel D and Alousi A and Cutler C and Aljurf M and Antin JH and Ayas M and Battiwalla M and Cahn JY and Cairo M and Chen YB and Gale RP and Hashmi S and Hayashi RJ and Jagasia M and Juckett M and Kamble RT and Kharfan-Dabaja M

DOI: 10.3324/haematol.2016.156356 PubMed: 28302712

03 / 2017

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease.

Cooke KR and Luznik L and Sarantopoulos S and Hakim FT and Jagasia M and Fowler DH and van den Brink MR and Hansen JA and Parkman R and Miklos DB and Martin PJ and Paczesny S and Vogelsang G and Pavletic S and Ritz J and Schultz KR and Blazar BR

DOI: 10.1016/j.bbmt.2016.09.023 PubMed: 27713092

02 / 2017

Y-box-binding protein 1 contributes to IL-7-mediated survival signaling in B-cell precursor acute lymphoblastic leukemia.

Kariminia A and Ivison SM and Leung VM and Sung S and Couto N and Rozmus J and Rolf N and Narendran A and Dunn SE and Reid GS and Schultz KR

DOI: 10.3892/ol.2016.5437 PubMed: 28123588

01 / 2017

Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study.

McMahon KR and Rod Rassekh S and Schultz KR and Pinsk M and Blydt-Hansen T and Mammen C and Tsuyuki RT and Devarajan P and Cuvelier GD and Mitchell LG and Baruchel S and Palijan A and Carleton BC and Ross CJ and Zappitelli M and Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Group

DOI: 10.1177/2054358117690338 PubMed: 28270931

National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Immune Dysregulation and Pathobiology Working Group Report.

Gea-Banacloche J and Komanduri KV and Carpenter P and Paczesny S and Sarantopoulos S and Young JA and El Kassar N and Le RQ and Schultz KR and Griffith LM and Savani BN and Wingard JR

DOI: 10.1016/j.bbmt.2016.10.001 PubMed: 27751936

10 / 2016

Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research.

Lazaryan A and Wang T and Spellman SR and Wang HL and Pidala J and Nishihori T and Askar M and Olsson R and Oudshoorn M and Abdel-Azim H and Yong A and Gandhi M and Dandoy C and Savani B and Hale G and Page K and Bitan M and Reshef R and Drobyski W and Marsh SG

DOI: 10.3324/haematol.2016.143271 PubMed: 27247320

10 / 2016

Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study.

Couban S and Aljurf M and Lachance S and Walker I and Toze C and Rubinger M and Lipton JH and Lee SJ and Szer R and Doocey R and Lewis ID and Huebsch L and Howson-Jan K and Lalancette M and Almohareb F and Chaudhri N and Ivison S and Broady R and Levings M and Fairclough D

DOI: 10.1016/j.bbmt.2016.04.017 PubMed: 27154847

08 / 2016

Quantitation of Human Cells that Produce Neutrophils and Platelets in Vivo Obtained from Normal Donors Treated with Granulocyte Colony-Stimulating Factor and/or Plerixafor.

Miller PH and Nakamichi N and Knapp DJ and Rabu G and Schultz KR and Jones DM and Couban S and Eaves CJ

DOI: 10.1016/j.bbmt.2016.07.023 PubMed: 27496214

08 / 2016

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation.

Rozmus J and McDonald R and Fung SY and Del Bel KL and Roden J and Senger C and Schultz KR and McKinnon ML and Davis J and Turvey SE

DOI: 10.1016/j.clim.2016.04.011 PubMed: 27109639

07 / 2016

Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells.

Kariminia A and Holtan SG and Ivison S and Rozmus J and Hebert MJ and Martin PJ and Lee SJ and Wolff D and Subrt P and Abdossamadi S and Sung S and Storek J and Levings M and Aljurf M and Arora M and Cutler C and Gallagher G and Kuruvilla J and Lipton J and Nevill TJ

DOI: 10.1182/blood-2015-09-668251 PubMed: 27020088

06 / 2016

Exome Sequencing and the Management of Neurometabolic Disorders.

Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drgemller BI and Abdelsayed M and Alfadhel M and Armstrong L and Baumgartner MR and Burda P and Connolly MB and Cameron J and Demos M and Dewan T and Dionne J

DOI: 10.1056/nejmoa1515792 PubMed: 27276562

06 / 2016

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.

Kumar R and Kimura F and Ahn KW and Hu ZH and Kuwatsuka Y and Klein JP and Pasquini M and Miyamura K and Kato K and Yoshimi A and Inamoto Y and Ichinohe T and Wood WA and Wirk B and Seftel M and Rowlings P and Marks DI and Schultz KR and Gupta V and Dedeken L

DOI: 10.1016/j.bbmt.2016.01.012 PubMed: 26797402

05 / 2016

Pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with haematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial.

Walker I and Panzarella T and Couban S and Couture F and Devins G and Elemary M and Gallagher G and Kerr H and Kuruvilla J and Lee SJ and Moore J and Nevill T and Popradi G and Roy J and Schultz KR and Szwajcer D and Toze C and Foley R and Canadian Blood and Marrow Transplant Group

DOI: 10.1016/s1470-2045(15)00462-3 PubMed: 26723083

02 / 2016

Pediatric chronic myeloid leukemia is a unique disease that requires a different approach

Blood

Nobuko Hijiya and Kirk R. Schultz and Markus Metzler and Frederic Millot and Meinolf Suttorp

DOI: 10.1182/blood-2015-06-648667

01 / 2016

In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children.

Ponce DM and Eapen M and Sparapani R and O'Brien TA and Chan KW and Chen J and Craddock J and Schultz KR and Wagner JE and Perales MA and Barker JN

DOI: 10.1016/j.bbmt.2015.08.022 PubMed: 26327630

12 / 2015

Functional hyposplenism after hematopoietic stem cell transplantation.

Rozmus J and Mallhi K and Ke J and Schultz KR

DOI: 10.1038/bmt.2015.160 PubMed: 26168071

10 / 2015

Second Allogeneic Hematopoietic Cell Transplantation for Patients with Fanconi Anemia and Bone Marrow Failure.

Ayas M and Eapen M and Le-Rademacher J and Carreras J and Abdel-Azim H and Alter BP and Anderlini P and Battiwalla M and Bierings M and Buchbinder DK and Bonfim C and Camitta BM and Fasth AL and Gale RP and Lee MA and Lund TC and Myers KC and Olsson RF and Page KM and Prestidge TD

DOI: 10.1016/j.bbmt.2015.06.012 PubMed: 26116087

10 / 2015

Risk factors and timing of relapse after allogeneic transplantation in pediatric ALL: for whom and when should interventions be tested?

Pulsipher MA and Langholz B and Wall DA and Schultz KR and Bunin N and Carroll W and Raetz E and Gardner S and Goyal RK and Gastier-Foster J and Borowitz M and Teachey D and Grupp SA

DOI: 10.1038/bmt.2015.103 PubMed: 25961775

09 / 2015

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. The 2014 Ancillary Therapy and Supportive Care Working Group Report.

Carpenter PA and Kitko CL and Elad S and Flowers ME and Gea-Banacloche JC and Halter JP and Hoodin F and Johnston L and Lawitschka A and McDonald GB and Opipari AW and Savani BN and Schultz KR and Smith SR and Syrjala KL and Treister N and Vogelsang GB and Williams KM and Pavletic SZ and Martin PJ

DOI: 10.1016/j.bbmt.2015.03.024 PubMed: 25838185

07 / 2015

Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia.

Rolf N and Kariminia A and Ivison S and Reid GS and Schultz KR

DOI: 10.1002/eji.201444874 PubMed: 25867213

07 / 2015

Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report.

Lee SJ and Wolff D and Kitko C and Koreth J and Inamoto Y and Jagasia M and Pidala J and Olivieri A and Martin PJ and Przepiorka D and Pusic I and Dignan F and Mitchell SA and Lawitschka A and Jacobsohn D and Hall AM and Flowers ME and Schultz KR and Vogelsang G and Pavletic S

DOI: 10.1016/j.bbmt.2015.02.025 PubMed: 25796139

06 / 2015

Circulating angiogenic factors associated with response and survival in patients with acute graft-versus-host disease: results from Blood and Marrow Transplant Clinical Trials Network 0302 and 0802.

Holtan SG and Verneris MR and Schultz KR and Newell LF and Meyers G and He F and DeFor TE and Vercellotti GM and Slungaard A and MacMillan ML and Cooley SA and Blazar BR and Panoskaltsis-Mortari A and Weisdorf DJ

DOI: 10.1016/j.bbmt.2015.02.018 PubMed: 25759146

06 / 2015

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: III. The 2014 Biomarker Working Group Report.

Paczesny S and Hakim FT and Pidala J and Cooke KR and Lathrop J and Griffith LM and Hansen J and Jagasia M and Miklos D and Pavletic S and Parkman R and Russek-Cohen E and Flowers ME and Lee S and Martin P and Vogelsang G and Walton M and Schultz KR

DOI: 10.1016/j.bbmt.2015.01.003 PubMed: 25644957

05 / 2015

IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients.

Pulsipher MA and Carlson C and Langholz B and Wall DA and Schultz KR and Bunin N and Kirsch I and Gastier-Foster JM and Borowitz M and Desmarais C and Williamson D and Kalos M and Grupp SA

DOI: 10.1182/blood-2014-12-615757 PubMed: 25862561

05 / 2015

NIH Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report.

Shulman HM and Cardona DM and Greenson JK and Hingorani S and Horn T and Huber E and Kreft A and Longerich T and Morton T and Myerson D and Prieto VG and Rosenberg A and Treister N and Washington K and Ziemer M and Pavletic SZ and Lee SJ and Flowers ME and Schultz KR and Jagasia M

DOI: 10.1016/j.bbmt.2014.12.031 PubMed: 25639770

04 / 2015

Hematopoietic Cell Transplantation and Cellular Therapeutics in the Treatment of Childhood Malignancies

Pediatric Clinics of North America

Kanwaldeep Mallhi and Lawrence G. Lum and Kirk R. Schultz and Maxim Yankelevich

DOI: 10.1016/j.pcl.2014.10.001

02 / 2015

Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research.

Arai S and Arora M and Wang T and Spellman SR and He W and Couriel DR and Urbano-Ispizua A and Cutler CS and Bacigalupo AA and Battiwalla M and Flowers ME and Juckett MB and Lee SJ and Loren AW and Klumpp TR and Prockup SE and Ringdn OT and Savani BN and Soci G and Schultz KR

DOI: 10.1016/j.bbmt.2014.10.021 PubMed: 25445023

02 / 2015

TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome. A joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study (ASCT0521).

Yanik GA and Grupp SA and Pulsipher MA and Levine JE and Schultz KR and Wall DA and Langholz B and Dvorak CC and Alangaden K and Goyal RK and White ES and Collura JM and Skeens MA and Eid S and Pierce EM and Cooke KR

DOI: 10.1016/j.bbmt.2014.09.019 PubMed: 25270958

01 / 2015

Hematopoietic Stem Cell Transplantation for X-Linked Thrombocytopenia With Mutations in the WAS gene.

Oshima K and Imai K and Albert MH and Bittner TC and Strauss G and Filipovich AH and Morio T and Kapoor N and Dalal J and Schultz KR and Casper JT and Notarangelo LD and Ochs HD and Nonoyama S

DOI: 10.1007/s10875-014-0105-5 PubMed: 25388447

01 / 2015

Is Any Donor Too Old?

Biology of Blood and Marrow Transplantation

Kirk R. Schultz

DOI: 10.1016/j.bbmt.2014.11.006

01 / 2015

New frontiers in pediatric Allo-SCT: novel approaches for children and adolescents with ALL.

Pulsipher MA and Wayne AS and Schultz KR

DOI: 10.1038/bmt.2014.114 PubMed: 24933210

10 / 2014

One-unit versus two-unit cord-blood transplantation for hematologic cancers.

Wagner JE and Eapen M and Carter S and Wang Y and Schultz KR and Wall DA and Bunin N and Delaney C and Haut P and Margolis D and Peres E and Verneris MR and Walters M and Horowitz MM and Kurtzberg J and Blood and Marrow Transplant Clinical Trials Network

DOI: 10.1056/nejmoa1405584 PubMed: 25354103

10 / 2014

Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation.

Pidala J and Lee SJ and Ahn KW and Spellman S and Wang HL and Aljurf M and Askar M and Dehn J and Fernandez Via M and Gratwohl A and Gupta V and Hanna R and Horowitz MM and Hurley CK and Inamoto Y and Kassim AA and Nishihori T and Mueller C and Oudshoorn M and Petersdorf EW

DOI: 10.1182/blood-2014-05-576041 PubMed: 25161269

10 / 2014

Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031

Leukemia

K R Schultz and A Carroll and N A Heerema and W P Bowman and A Aledo and W B Slayton and H Sather and M Devidas and H W Zheng and S M Davies and P S Gaynon and M Trigg and R Rutledge and D Jorstad and N Winick and M J Borowitz and S P Hunger and W L Carroll and B Camitta

DOI: 10.1038/leu.2014.30

07 / 2014

Combined immunodeficiency associated with homozygous MALT1 mutations.

McKinnon ML and Rozmus J and Fung SY and Hirschfeld AF and Del Bel KL and Thomas L and Marr N and Martin SD and Marwaha AK and Priatel JJ and Tan R and Senger C and Tsang A and Prendiville J and Junker AK and Seear M and Schultz KR and Sly LM and Holt RA and Patel MS

DOI: 10.1016/j.jaci.2013.10.045 PubMed: 24332264

05 / 2014

Philadelphia chromosome-negative very high-risk acute lymphoblastic leukemia in children and adolescents: results from Children's Oncology Group Study AALL0031.

Schultz KR and Devidas M and Bowman WP and Aledo A and Slayton WB and Sather H and Zheng HW and Davies SM and Gaynon PS and Trigg M and Rutledge R and Jorstad D and Carroll AJ and Heerema N and Winick N and Borowitz MJ and Hunger SP and Carroll WL and Camitta B and Childrens Oncology Group

DOI: 10.1038/leu.2014.29 PubMed: 24434862

04 / 2014

Transplantation for children with acute myeloid leukemia: a comparison of outcomes with reduced intensity and myeloablative regimens.

Bitan M and He W and Zhang MJ and Abdel-Azim H and Ayas MF and Bielorai B and Carpenter PA and Cairo MS and Diaz MA and Horan JT and Jodele S and Kitko CL and Schultz KR and Kletzel M and Kasow KA and Lehmann LE and Mehta PA and Shah N and Pulsipher MA and Prestidge T

DOI: 10.1182/blood-2013-10-535716 PubMed: 24435046

03 / 2014

The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial.

Pulsipher MA and Langholz B and Wall DA and Schultz KR and Bunin N and Carroll WL and Raetz E and Gardner S and Gastier-Foster JM and Howrie D and Goyal RK and Douglas JG and Borowitz M and Barnes Y and Teachey DT and Taylor C and Grupp SA

DOI: 10.1182/blood-2013-10-534297 PubMed: 24497539

03 / 2014

Paroxysmal nocturnal haemoglobinuria phenotype cells and leucocyte subset telomere length in childhood acquired aplastic anaemia.

Tutelman PR and Aubert G and Milner RA and Dalal BI and Schultz KR and Deyell RJ

DOI: 10.1111/bjh.12656 PubMed: 24236830

03 / 2014

Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation.

Fernandez-Via MA and Wang T and Lee SJ and Haagenson M and Aljurf M and Askar M and Battiwalla M and Baxter-Lowe LA and Gajewski J and Jakubowski AA and Marino S and Oudshoorn M and Marsh SG and Petersdorf EW and Schultz K and Turner EV and Waller EK and Woolfrey A and Umejiego J and Spellman SR

DOI: 10.1182/blood-2013-10-532671 PubMed: 24408320

02 / 2014

Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality.

Pidala J and Wang T and Haagenson M and Spellman SR and Askar M and Battiwalla M and Baxter-Lowe LA and Bitan M and Fernandez-Via M and Gandhi M and Jakubowski AA and Maiers M and Marino SR and Marsh SG and Oudshoorn M and Palmer J and Prasad VK and Reddy V and Ringden O and Saber W

DOI: 10.1182/blood-2013-05-501510 PubMed: 23982174

11 / 2013

Severe combined immunodeficiency (SCID) in Canadian children: a national surveillance study.

Rozmus J and Junker A and Thibodeau ML and Grenier D and Turvey SE and Yacoub W and Embree J and Haddad E and Langley JM and Ramsingh RM and Singh VA and Long R and Schultz KR

DOI: 10.1007/s10875-013-9952-8 PubMed: 24122030

11 / 2013

STAT3 mutations and persistence of autoimmunity.

Schultz KR

DOI: 10.1182/blood-2013-08-521138 PubMed: 24092924

10 / 2013

Impact of prior acute GVHD on chronic GVHD outcomes: a chronic graft versus host disease consortium study.

Arora M and Pidala J and Cutler CS and Chai X and Kurland B and Jacobsohn DA and Pavletic SZ and Palmer J and Vogelsang G and Jagasia M and Schultz K and Lee SJ

DOI: 10.1038/leu.2012.292 PubMed: 23047477

04 / 2013

Prediction of area under the cyclosporine concentration versus time curve in children undergoing hematopoietic stem cell transplantation.

Dupuis LL and Seto W and Teuffel O and Gibson P and Schultz KR and Doyle JD and Gassas A and Egeler RM and Sung L and Schechter T

DOI: 10.1016/j.bbmt.2012.10.031 PubMed: 23128321

03 / 2013

Excess of veno-occlusive disease in a randomized clinical trial on a higher trigger for red blood cell transfusion after bone marrow transplantation: a canadian blood and marrow transplant group trial.

Robitaille N and Lacroix J and Alexandrov L and Clayton L and Cortier M and Schultz KR and Bittencourt H and Duval M

DOI: 10.1016/j.bbmt.2012.12.002 PubMed: 23220014

03 / 2013

Poor agreement between clinician response ratings and calculated response measures in patients with chronic graft-versus-host disease.

Palmer JM and Lee SJ and Chai X and Storer BE and Flowers ME and Schultz KR and Inamoto Y and Cutler C and Pidala J and Arora M and Jacobsohn DA and Carpenter PA and Pavletic SZ and Martin PJ

DOI: 10.1016/j.bbmt.2012.05.005 PubMed: 22691695

11 / 2012

HLA-matched sibling transplantation for severe aplastic anemia: impact of HLA DR15 antigen status on engraftment, graft-versus-host disease, and overall survival.

Battiwalla M and Wang T and Carreras J and Deeg HJ and Ayas M and Bajwa RP and George B and Gupta V and Pasquini R and Schrezenmeier H and Passweg JR and Schultz KR and Eapen M

DOI: 10.1016/j.bbmt.2012.02.007 PubMed: 22387349

09 / 2012

Unrelated donor cord blood transplantation for children with severe sickle cell disease: results of one cohort from the phase II study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN).

Kamani NR and Walters MC and Carter S and Aquino V and Brochstein JA and Chaudhury S and Eapen M and Freed BM and Grimley M and Levine JE and Logan B and Moore T and Panepinto J and Parikh S and Pulsipher MA and Sande J and Schultz KR and Spellman S and Shenoy S

DOI: 10.1016/j.bbmt.2012.01.019 PubMed: 22343376

08 / 2012

Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph+ ALL: a Children's Oncology Group (COG) study.

Chang BH and Willis SG and Stork L and Hunger SP and Carroll WL and Camitta BM and Winick NJ and Druker BJ and Schultz KR

DOI: 10.1111/j.1365-2141.2012.09039.x PubMed: 22299775

05 / 2012

Inhibition of cathepsin S reduces allogeneic T cell priming but not graft-versus-host disease against minor histocompatibility antigens.

Fujii H and Ivison SM and Shimizu H and Kajiwara R and Kariminia A and Yan M and Dutz JP and Schultz KR

DOI: 10.1016/j.bbmt.2011.11.027 PubMed: 22178962

04 / 2012

Randomized trial of hydroxychloroquine for newly diagnosed chronic graft-versus-host disease in children: a Children's Oncology Group study.

Gilman AL and Schultz KR and Goldman FD and Sale GE and Krailo MD and Chen Z and Langholz B and Jacobsohn DA and Chan KW and Ryan RE and Kellick M and Neudorf SM and Godder K and Sandler ES and Sahdev I and Grupp SA and Sanders JE and Wall DA

DOI: 10.1016/j.bbmt.2011.05.016 PubMed: 21689773

01 / 2012

Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031.

Rozmus J and Schultz KR and Wynne K and Kariminia A and Satyanarayana P and Krailo M and Grupp SA and Gilman AL and Goldman FD

DOI: 10.1016/j.bbmt.2011.05.011 PubMed: 21669298

12 / 2011

Rationale and design of the chronic GVHD cohort study: improving outcomes assessment in chronic GVHD.

Chronic GVHD Consortium

DOI: 10.1016/j.bbmt.2011.05.007 PubMed: 21664473

08 / 2011

Biomarkers in chronic graft-versus-host disease

Expert Review of Hematology

Jacob Rozmus and Kirk R Schultz

DOI: 10.1586/ehm.11.27

06 / 2011

Immunosuppressive Therapy Without Hematopoietic Growth Factor Exposure in Pediatric Acquired Aplastic Anemia

Pediatric Hematology and Oncology

Rebecca J. Deyell and Evan B. Shereck and Ruth A. Milner and Kirk R. Schultz

DOI: 10.3109/08880018.2011.568043

06 / 2011

Unrelated donor bone marrow transplantation for myelodysplastic syndrome in children.

Woodard P and Carpenter PA and Davies SM and Gross TG and He W and Zhang MJ and Horn BN and Margolis DA and Perentesis JP and Sanders JE and Schultz KR and Seber A and Woods WG and Eapen M

DOI: 10.1016/j.bbmt.2010.08.016 PubMed: 20813197

05 / 2011

Controversies in the Treatment of CML in Children and Adolescents: TKIs versus BMT?

Biology of Blood and Marrow Transplantation

Meinolf Suttorp and Isaac Yaniv and Kirk R. Schultz

DOI: 10.1016/j.bbmt.2010.09.003

01 / 2011

Philadelphia chromosome-positive acute lymphoblastic leukemia in children: new and emerging treatment options.

Schultz KR and Prestidge T and Camitta B

DOI: 10.1586/ehm.10.60 PubMed: 21091149

12 / 2010

Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031.

Cuvelier GD and Kariminia A and Fujii H and Aslanian S and Wall D and Goldman F and Grupp SA and Dunn SE and Krailo M and Shapiro LH and Gilman A and Schultz KR

DOI: 10.1038/bmt.2010.15 PubMed: 20190833

11 / 2010

Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related, or matched unrelated donors.

Shaw PJ and Kan F and Woo Ahn K and Spellman SR and Aljurf M and Ayas M and Burke M and Cairo MS and Chen AR and Davies SM and Frangoul H and Gajewski J and Gale RP and Godder K and Hale GA and Heemskerk MB and Horan J and Kamani N and Kasow KA and Chan KW

DOI: 10.1182/blood-2010-01-261958 PubMed: 20671124

11 / 2010

Advancement of pediatric blood and marrow transplantation research in North America: priorities of the Pediatric Blood and Marrow Transplant Consortium.

Pulsipher MA and Horwitz EM and Haight AE and Kadota R and Chen AR and Frangoul H and Cooper LJ and Jacobsohn DA and Goyal RK and Mitchell D and Nieder ML and Yanik G and Cowan MJ and Soni S and Gardner S and Shenoy S and Taylor D and Cairo M and Schultz KR

DOI: 10.1016/j.bbmt.2009.12.536 PubMed: 20079865

09 / 2010

Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure.

Duval M and Klein JP and He W and Cahn JY and Cairo M and Camitta BM and Kamble R and Copelan E and de Lima M and Gupta V and Keating A and Lazarus HM and Litzow MR and Marks DI and Maziarz RT and Rizzieri DA and Schiller G and Schultz KR and Tallman MS and Weisdorf D

DOI: 10.1200/jco.2010.28.8852 PubMed: 20625136

08 / 2010

Tumor necrosis factor-alpha gene polymorphisms are associated with severity of acute graft-versus-host disease following matched unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study.

Goyal RK and Lin Y and Schultz KR and Ferrell RE and Kim Y and Fairfull L and Livote E and Yanik G and Atlas M

DOI: 10.1016/j.bbmt.2010.01.009 PubMed: 20100586

07 / 2010

Haploidentical transplantation in children.

Schultz KR

DOI: 10.1182/blood-2010-01-263657 PubMed: 20430960

04 / 2010

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

Medyouf H and Gao X and Armstrong F and Gusscott S and Liu Q and Gedman AL and Matherly LH and Schultz KR and Pflumio F and You MJ and Weng AP

DOI: 10.1182/blood-2009-04-214718 PubMed: 20008304

02 / 2010

Chronic Graft-Versus-Host Disease (GVHD) in Children

Pediatric Clinics of North America

Kristin Baird and Kenneth Cooke and Kirk R. Schultz

DOI: 10.1016/j.pcl.2009.11.003

02 / 2010

Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.

Griffith LM and Cowan MJ and Notarangelo LD and Puck JM and Buckley RH and Candotti F and Conley ME and Fleisher TA and Gaspar HB and Kohn DB and Ochs HD and O'Reilly RJ and Rizzo JD and Roifman CM and Small TN and Shearer WT and Workshop Participants

DOI: 10.1016/j.jaci.2009.10.022 PubMed: 20004776

12 / 2009

Impact of conditioning regimen in allogeneic hematopoetic stem cell transplantation for children with acute myelogenous leukemia beyond first complete remission: a pediatric blood and marrow transplant consortium (PBMTC) study.

Sisler IY and Koehler E and Koyama T and Domm JA and Ryan R and Levine JE and Pulsipher MA and Haut PR and Schultz KR and Taylor DS and Frangoul HA

DOI: 10.1016/j.bbmt.2009.08.014 PubMed: 19896086

12 / 2009

Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study.

Schultz KR and Bowman WP and Aledo A and Slayton WB and Sather H and Devidas M and Wang C and Davies SM and Gaynon PS and Trigg M and Rutledge R and Burden L and Jorstad D and Carroll A and Heerema NA and Winick N and Borowitz MJ and Hunger SP and Carroll WL and Camitta B

DOI: 10.1200/jco.2008.21.2514 PubMed: 19805687

11 / 2009

Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study.

Jacobsohn DA and Gilman AL and Rademaker A and Browning B and Grimley M and Lehmann L and Nemecek ER and Thormann K and Schultz KR and Vogelsang GB

DOI: 10.1182/blood-2009-05-224840 PubMed: 19745067

11 / 2009

Intracranial calcification after cord blood neonatal transplantation for krabbe disease.

Lehman AM and Schultz KR and Poskitt K and Bjornson B and Keyes R and Waters PJ and Clarke LA and Everett R and McConnell D and Stockler S

DOI: 10.1055/s-0029-1243189 PubMed: 20135576

08 / 2009

The long-term outcomes of presymptomatic infants transplanted for Krabbe disease: report of the workshop held on July 11 and 12, 2008, Holiday Valley, New York.

Duffner PK and Caviness VS and Erbe RW and Patterson MC and Schultz KR and Wenger DA and Whitley C

DOI: 10.1097/gim.0b013e3181a16e04 PubMed: 19346954

06 / 2009

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.

Cuvelier GD and Schultz KR and Davis J and Hirschfeld AF and Junker AK and Tan R and Turvey SE

DOI: 10.1016/j.clim.2009.01.003 PubMed: 19217351

05 / 2009

44. Outcomes of children transplanted for Krabbe disease

Molecular Genetics and Metabolism

Patricia Duffner and Rajinder Bawa and Martin Champagne and Lawrence Charnas and Morris Kletzl and Daniel Pietryga and Kirk Schultz and Brandon Triplett

DOI: 10.1016/j.ymgme.2008.11.045

02 / 2009

Controversies of and unique issues in hematopoietic cell transplantation for infant leukemia.

Hunger SP and Loh KM and Baker KS and Schultz KR

DOI: 10.1016/j.bbmt.2008.10.015 PubMed: 19147083

01 / 2009

Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs.

Griffith LM and Cowan MJ and Kohn DB and Notarangelo LD and Puck JM and Schultz KR and Buckley RH and Eapen M and Kamani NR and O'Reilly RJ and Parkman R and Roifman CM and Sullivan KE and Filipovich AH and Fleisher TA and Shearer WT

DOI: 10.1016/j.jaci.2008.09.045 PubMed: 18992926

12 / 2008

Detection of WT1-specific T cells in paediatric acute lymphoblastic leukaemia patients in first remission.

Barbaric D and Corthals SL and Jastaniah WA and Asalanian S and Shimizu H and Reid GS and Schultz KR

DOI: 10.1111/j.1365-2141.2008.07001.x PubMed: 18307567

04 / 2008

Chronic Graft-versus-Host Disease--implementation of the National Institutes of Health Consensus Criteria for Clinical Trials.

Griffith LM and Pavletic SZ and Lee SJ and Martin PJ and Schultz KR and Vogelsang GB

DOI: 10.1016/j.bbmt.2008.01.005 PubMed: 18342779

04 / 2008

Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the Children's Oncology Group.

Fujii H and Cuvelier G and She K and Aslanian S and Shimizu H and Kariminia A and Krailo M and Chen Z and McMaster R and Bergman A and Goldman F and Grupp SA and Wall DA and Gilman AL and Schultz KR

DOI: 10.1182/blood-2007-08-106286 PubMed: 17925486

03 / 2008

A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study.

Bond M and Bernstein ML and Pappo A and Schultz KR and Krailo M and Blaney SM and Adamson PC

DOI: 10.1002/pbc.21132 PubMed: 17262795

02 / 2008

Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease.

She K and Gilman AL and Aslanian S and Shimizu H and Krailo M and Chen Z and Reid GS and Wall D and Goldman F and Schultz KR

DOI: 10.1016/j.bbmt.2006.12.441 PubMed: 17382246

04 / 2007

In vivo control of acute lymphoblastic leukemia by immunostimulatory CpG oligonucleotides.

Fujii H and Trudeau JD and Teachey DT and Fish JD and Grupp SA and Schultz KR and Reid GS

DOI: 10.1182/blood-2006-02-002055 PubMed: 17068155

03 / 2007

Allogeneic bone marrow transplantation in first remission for children with ultra-high-risk features of acute lymphoblastic leukemia: A children's oncology group study report.

Satwani P and Sather H and Ozkaynak F and Heerema NA and Schultz KR and Sanders J and Kersey J and Davenport V and Trigg M and Cairo MS

DOI: 10.1016/j.bbmt.2006.09.013 PubMed: 17241927

02 / 2007

Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG).

Schultz KR and Pullen DJ and Sather HN and Shuster JJ and Devidas M and Borowitz MJ and Carroll AJ and Heerema NA and Rubnitz JE and Loh ML and Raetz EA and Winick NJ and Hunger SP and Carroll WL and Gaynon PS and Camitta BM

DOI: 10.1182/blood-2006-01-024729 PubMed: 17003380

02 / 2007

Transplantation for Childhood Acute Lymphoblastic Leukemia

Pediatric Hematopoietic Stem Cell Transplantation

Donna Wall and Kirk Schultz and Gregor Reid

DOI: 10.3109/9780849358807-25

07 / 2006

Chronic Graft-Versus-Host Disease in Children

Pediatric Hematopoietic Stem Cell Transplantation

David Jacobsohn and Georgia Vogelsang and Kirk Schultz

DOI: 10.3109/9780849358807-5

07 / 2006

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group report.

Martin PJ and Weisdorf D and Przepiorka D and Hirschfeld S and Farrell A and Rizzo JD and Foley R and Socie G and Carter S and Couriel D and Schultz KR and Flowers ME and Filipovich AH and Saliba R and Vogelsang GB and Pavletic SZ and Lee SJ and Design of Clinical Trials Working Group

DOI: 10.1016/j.bbmt.2006.03.004 PubMed: 16635784

05 / 2006

Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report.

Couriel D and Carpenter PA and Cutler C and Bolaos-Meade J and Treister NS and Gea-Banacloche J and Shaughnessy P and Hymes S and Kim S and Wayne AS and Chien JW and Neumann J and Mitchell S and Syrjala K and Moravec CK and Abramovitz L and Liebermann J and Berger A and Gerber L and Schubert M

DOI: 10.1016/j.bbmt.2006.02.003 PubMed: 16545722

04 / 2006

HLA-DM expression is elevated in ETV6"AML1 translocation-positive pediatric acute lymphoblastic leukemia

Leukemia Research

Wasil A. Jastaniah and Angela J. Alessandri and Gregor S.D. Reid and Kirk R. Schultz

DOI: 10.1016/j.leukres.2005.08.013

04 / 2006

Use of G-CSF in matched sibling donor pediatric allogeneic transplantation: a consensus statement from the Children's Oncology Group (COG) Transplant Discipline Committee and Pediatric Blood and Marrow Transplant Consortium (PBMTC) Executive Committee.

Grupp SA and Frangoul H and Wall D and Pulsipher MA and Levine JE and Schultz KR

DOI: 10.1002/pbc.20800 PubMed: 16463346

04 / 2006

A comparison of cyclophosphamide and total body irradiation with etoposide and total body irradiation as conditioning regimens for patients undergoing sibling allografting for acute lymphoblastic leukemia in first or second complete remission.

Marks DI and Forman SJ and Blume KG and Prez WS and Weisdorf DJ and Keating A and Gale RP and Cairo MS and Copelan EA and Horan JT and Lazarus HM and Litzow MR and McCarthy PL and Schultz KR and Smith DD and Trigg ME and Zhang MJ and Horowitz MM

DOI: 10.1016/j.bbmt.2005.12.029 PubMed: 16545728

04 / 2006

Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group report.

Pavletic SZ and Martin P and Lee SJ and Mitchell S and Jacobsohn D and Cowen EW and Turner ML and Akpek G and Gilman A and McDonald G and Schubert M and Berger A and Bross P and Chien JW and Couriel D and Dunn JP and Fall-Dickson J and Farrell A and Flowers ME and Greinix H

DOI: 10.1016/j.bbmt.2006.01.008 PubMed: 16503494

03 / 2006

Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report.

Schultz KR and Miklos DB and Fowler D and Cooke K and Shizuru J and Zorn E and Holler E and Ferrara J and Shulman H and Lee SJ and Martin P and Filipovich AH and Flowers ME and Weisdorf D and Couriel D and Lachenbruch PA and Mittleman B and Vogelsang GB and Pavletic SZ

DOI: 10.1016/j.bbmt.2005.11.010 PubMed: 16443511

02 / 2006

Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report.

Shulman HM and Kleiner D and Lee SJ and Morton T and Pavletic SZ and Farmer E and Moresi JM and Greenson J and Janin A and Martin PJ and McDonald G and Flowers ME and Turner M and Atkinson J and Lefkowitch J and Washington MK and Prieto VG and Kim SK and Argenyi Z and Diwan AH

DOI: 10.1016/j.bbmt.2005.10.023 PubMed: 16399567

01 / 2006

National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report.

Filipovich AH and Weisdorf D and Pavletic S and Socie G and Wingard JR and Lee SJ and Martin P and Chien J and Przepiorka D and Couriel D and Cowen EW and Dinndorf P and Farrell A and Hartzman R and Henslee-Downey J and Jacobsohn D and McDonald G and Mittleman B and Rizzo JD and Robinson M

DOI: 10.1016/j.bbmt.2005.09.004 PubMed: 16338616

12 / 2005

Outcome of ethnic minorities with acute or chronic leukemia treated with hematopoietic stem-cell transplantation in the United States.

Baker KS and Loberiza FR and Yu H and Cairo MS and Bolwell BJ and Bujan-Boza WA and Camitta BM and Garcia JJ and Ho WG and Liesveld JL and Maharaj D and Marks DI and Schultz KR and Wiernik P and Zander AR and Horowitz MM and Keating A and Weisdorf DJ

DOI: 10.1200/jco.2005.01.7269 PubMed: 16145067

10 / 2005

Inhibition of Cathepsin S Alters the T Cell Response to Minor Histocompatibility Antigens

Journal of Pediatric Hematology/Oncology

Hisaki Fujii and Hiromi Shimizu and Zhijuan Luo and Kirk R Schultz

DOI: 10.1097/01.mph.0000188542.01395.3f

09 / 2005

Increased TLR9 Responses in B Cells at the Onset of Chronic GVHD

Journal of Pediatric Hematology/Oncology

Kevin She and Soudabeh Aslanian and Hiromi Shimizu and Andrew L Gilman and Kirk R Schultz

DOI: 10.1097/01.mph.0000188527.40641.1b

09 / 2005

High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative.

Sutcliffe MJ and Shuster JJ and Sather HN and Camitta BM and Pullen J and Schultz KR and Borowitz MJ and Gaynon PS and Carroll AJ and Heerema NA

DOI: 10.1038/sj.leu.2403673 PubMed: 15789069

05 / 2005

CpG stimulation of precursor B-lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells toward a Th1 response.

Reid GS and She K and Terrett L and Food MR and Trudeau JD and Schultz KR

DOI: 10.1182/blood-2004-06-2468 PubMed: 15650062

05 / 2005

The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML).

Hasle H and Baumann I and Bergstrsser E and Fenu S and Fischer A and Kardos G and Kerndrup G and Locatelli F and Rogge T and Schultz KR and Star J and Trebo M and van den Heuvel-Eibrink MM and Harbott J and Nllke P and Niemeyer CM and European Working Group on childhood MDS

DOI: 10.1038/sj.leu.2403489 PubMed: 15496981

12 / 2004

Coronary vessel involvement by chronic graft-versus-host disease presenting as sudden cardiac death.

Prevost D and Taylor G and Sanatani S and Schultz KR

DOI: 10.1038/sj.bmt.1704625 PubMed: 15300232

10 / 2004

Differential effects of granulocyte colony-stimulating factor on marrow- and blood-derived hematopoietic and immune cell populations in healthy human donors.

Shier LR and Schultz KR and Imren S and Regan J and Issekutz A and Sadek I and Gilman A and Luo Z and Panzarella T and Eaves CJ and Couban S

DOI: 10.1016/j.bbmt.2004.05.009 PubMed: 15319774

09 / 2004

A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome.

Cutler CS and Lee SJ and Greenberg P and Deeg HJ and Prez WS and Anasetti C and Bolwell BJ and Cairo MS and Gale RP and Klein JP and Lazarus HM and Liesveld JL and McCarthy PL and Milone GA and Rizzo JD and Schultz KR and Trigg ME and Keating A and Weisdorf DJ and Antin JH

DOI: 10.1182/blood-2004-01-0338 PubMed: 15039286

07 / 2004

Expression of the adaptor protein BLNK/SLP-65 in childhood acute lymphoblastic leukemia.

Imai C and Ross ME and Reid G and Coustan-Smith E and Schultz KR and Pui CH and Downing JR and Campana D

DOI: 10.1038/sj.leu.2403349 PubMed: 15029213

05 / 2004

Canadian multicenter pilot trial of haploidentical donor transplantation.

Walker I and Shehata N and Cantin G and Couture F and Dhdin N and Barty R and Foley R and Sutherland RD and Sigouin C and Schultz KR and Mitchell D and Canadian Blood and Marrow Transplant Group

DOI: 10.1016/j.bcmd.2004.08.006 PubMed: 15528135

Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells.

Reid GS and Terrett L and Alessandri AJ and Grubb S and Stork L and Seibel N and Gaynon P and Schultz KR

DOI: 10.1016/s0145-2126(03)00106-1 PubMed: 12921952

12 / 2003

Refractory anemia in childhood: a retrospective analysis of 67 patients with particular reference to monosomy 7.

Kardos G and Baumann I and Passmore SJ and Locatelli F and Hasle H and Schultz KR and Star J and Schmitt-Graeff A and Fischer A and Harbott J and Chessells JM and Hann I and Fenu S and Rajnoldi AC and Kerndrup G and Van Wering E and Rogge T and Nollke P and Niemeyer CM

DOI: 10.1182/blood-2002-11-3444 PubMed: 12763938

09 / 2003

Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy.

McCahon E and Sorensen PH and Davis JH and Rogers PC and Schultz KR

DOI: 10.1002/mpo.10272 PubMed: 12652616

05 / 2003

The impact of Asian descent on the incidence of acquired severe aplastic anaemia in children.

McCahon E and Tang K and Rogers PC and McBride ML and Schultz KR

DOI: 10.1046/j.1365-2141.2003.04236.x PubMed: 12670349

04 / 2003

Comparison of outcome following allogeneic bone marrow transplantation with cyclophosphamide-total body irradiation versus busulphan-cyclophosphamide conditioning regimens for acute myelogenous leukaemia in first remission.

Litzow MR and Prez WS and Klein JP and Bolwell BJ and Camitta B and Copelan EA and Gale RP and Giralt SA and Keating A and Lazarus HM and Marks DI and McCarthy PL and Miller CB and Milone G and Prentice HG and Russell JA and Schultz KR and Trigg ME and Weisdorf DJ and Horowitz MM

DOI: 10.1046/j.1365-2141.2002.03973.x PubMed: 12472596

12 / 2002

Evaluation for synergistic suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a rapamycin derivative, SDZ-RAD.

Hsiao CC and Su WN and Forooghian F and Bader S and Rempel J and HayGlass KT and Gilman A and Schultz KR

DOI: 10.1038/sj.bmt.1703727 PubMed: 12476284

12 / 2002

Differential killing of pre-B acute lymphoblastic leukaemia cells by activated NK cells and the NK-92 ci cell line.

Reid GS and Bharya S and Klingemann HG and Schultz KR

DOI: 10.1046/j.1365-2249.2002.01919.x PubMed: 12165082

08 / 2002

A population-based study of pediatric anaplastic large cell lymphoma

Cancer

Angela J. Alessandri and Sheila L. Pritchard and Kirk R. Schultz and Bonnie G. Massing

DOI: 10.1002/cncr.10396

03 / 2002

ETV6 (TEL)-AML1 pre-B acute lymphoblastic leukaemia cells are associated with a distinct antigen-presenting phenotype.

Alessandri AJ and Reid GS and Bader SA and Massing BG and Sorensen PH and Schultz KR

DOI: 10.1046/j.0007-1048.2001.03291.x PubMed: 11841426

02 / 2002

Autologous versus allogeneic unrelated donor transplantation for acute lymphoblastic leukemia: comparative toxicity and outcomes.

Weisdorf D and Bishop M and Dharan B and Bolwell B and Cahn JY and Cairo M and Giralt S and Klein J and Lazarus H and Litzow M and Marks D and McCarthy P and Miller C and Milone G and Russell J and Schultz KR and Sierra J and Wiernik P and Keating A and Loberiza F

DOI: 10.1053/bbmt.2002.v8.pm12014810 PubMed: 12014810

Chloroquine prevention of murine MHC-disparate acute graft-versus-host disease correlates with inhibition of splenic response to CpG oligodeoxynucleotides and alterations in T-cell cytokine production.

Schultz KR and Su WN and Hsiao CC and Doho G and Jevon G and Bader S and MacFarlane DE and Gilman AL

DOI: 10.1053/bbmt.2002.v8.abbmt080648 PubMed: 12523576

Absence of t(12;15) associatedETV6-NTRK3 fusion transcripts in pediatric acute leukemias

Medical and Pediatric Oncology

Angela J. Alessandri and Stevan R. Knezevich and Joan A. Mathers and Kirk R. Schultz and Poul H.B. Sorensen

DOI: 10.1002/mpo.1222

Effect of gastrointestinal inflammation and age on the pharmacokinetics of oral microemulsion cyclosporin A in the first month after bone marrow transplantation.

Schultz KR and Nevill TJ and Balshaw RF and Toze CL and Corr T and Currie CJ and Strong DK and Keown PA

DOI: 10.1038/sj.bmt.1702545 PubMed: 11019845

09 / 2000

Treatment of chronic GVHD.

Gilman AL and Schultz KR

DOI: 10.1038/sj.bmt.1702530 PubMed: 10982297

08 / 2000

Effect of nucleated marrow cell dose on relapse and survival in identical twin bone marrow transplants for leukemia.

Barrett AJ and Ringdn O and Zhang MJ and Bashey A and Cahn JY and Cairo MS and Gale RP and Gratwohl A and Locatelli F and Martino R and Schultz KR and Tiberghien P

PubMed: 10828011

06 / 2000

Age is the major determinant of recurrence in pediatric differentiated thyroid carcinoma

Medical and Pediatric Oncology

Angela J. Alessandri and Karen J. Goddard and Geoffrey K. Blair and Chris J.H. Fryer and Kirk R. Schultz

DOI: 10.1002/1096-911x(200007)35:1u003C41::aid-mpo7u003E3.0.co;2-7

Hydroxychloroquine for the treatment of chronic graft-versus-host disease.

Gilman AL and Chan KW and Mogul A and Morris C and Goldman FD and Boyer M and Cirenza E and Mazumder A and Gehan E and Cahill R and Frankel S and Schultz K

DOI: 10.1016/s1083-8791(00)70058-9 PubMed: 10905770

A population-based study of childhood myelodysplastic syndrome in British Columbia, Canada.

Hasle H and Wadsworth LD and Massing BG and McBride M and Schultz KR

DOI: 10.1046/j.1365-2141.1999.01645.x PubMed: 10520007

09 / 1999

Misleading leads: Bone pain caused by isolated paraspinal extramedullary relapse of childhood acute lymphoblastic leukemia.

Alessandri AJ and Pritchard SL and Massing BG and Sargent MA and Theissen P and Schultz KR

DOI: 10.1002/(sici)1096-911x(199908)33:2u003C113::aid-mpo10u003E3.0.co;2-k PubMed: 10398187

08 / 1999

The pharmacokinetics of oral cyclosporin A (Neoral) during the first month after bone marrow transplantation.

Schultz KR and Nevill TJ and Toze CL and Corr T and Currie C and Strong DK and Keown PA

DOI: 10.1016/s0041-1345(98)00385-6 PubMed: 9723236

08 / 1998

Immune suppression by lysosomotropic amines and cyclosporine on T-cell responses to minor and major histocompatibility antigens: does synergy exist?

Schultz KR and Bader S and Nelson D and Wang MD and HayGlass KT

DOI: 10.1097/00007890-199710150-00019 PubMed: 9381529

10 / 1997

Importance of the day 7 bone marrow biopsy as a prognostic measure of the outcome in children with acute lymphoblastic leukemia.

Schultz KR and Massing B and Spinelli JJ and Gaynon PS and Wadsworth L

DOI: 10.1002/(sici)1096-911x(199707)29:1u003C16::aid-mpo3u003E3.0.co;2-v PubMed: 9142200

07 / 1997

Treatment of familial erythrophagocytic lymphohistiocytosis with cyclosporine A

The Journal of Pediatrics

Esteban M. Abella and John Artrip and Kirk Schultz and Yaddanapudi Ravindranath

DOI: 10.1016/s0022-3476(97)70212-9

03 / 1997

The Lysosomotropic Amines, Chloroquine and Hydroxychloroquine: A Potentially Novel Therapy for Graft-Versus-Host Disease

Leukemia & Lymphoma

Kirk R. Schultz and Andrew L. Gilman

DOI: 10.3109/10428199709039008

01 / 1997

Immunosuppressive therapy: a potential alternative to bone marrow transplantation as initial therapy for acquired severe aplastic anemia in childhood?

Lawlor ER and Anderson RA and Davis JH and Fryer CJ and Pritchard SL and Rogers PC and Wu JK and Schultz KR

DOI: 10.1097/00043426-199703000-00004 PubMed: 9149740

Synergy between lysosomotropic amines and cyclosporin A on human T cell responses to an exogenous protein antigen, tetanus toxoid.

Schultz KR and Nelson D and Bader S

PubMed: 8879628

09 / 1996

Chloroquine treatment affects T-cell priming to minor histocompatibility antigens and graft-versus-host disease.

Schultz KR and Bader S and Paquet J and Li W

PubMed: 7492796

12 / 1995

Genetic heterogeneity in familial dilated cardiomyopathy.

Schultz KR and Gajarski RJ and Pignatelli R and Goytia V and Roberts R and Bachinski L and Towbin JA

DOI: 10.1006/bmme.1995.1061 PubMed: 8825069

12 / 1995

Requirement for B cells in T cell priming to minor histocompatibility antigens and development of graft-versus-host disease.

Schultz KR and Paquet J and Bader S and HayGlass KT

PubMed: 7581150

08 / 1995

Association of gastroesophageal reflux with obstructive lung disease in children after allogeneic bone marrow transplantation.

Schultz KR and Fernandez CV and Israel DM and Magee F and Wensley D and Sargent MA and Abella E and Karanes C

PubMed: 7780159

06 / 1995

Cyclosporin A therapy of immune-mediated thrombocytopenia in children.

Schultz KR and Strahlendorf C and Warrier I and Ravindranath Y

PubMed: 7858273

03 / 1995

Obstructive lung disease in children after allogeneic bone marrow transplantation.

Schultz KR and Green GJ and Wensley D and Sargent MA and Magee JF and Spinelli JJ and Pritchard S and Davis JH and Rogers PC and Chan KW

PubMed: 7949192

11 / 1994

Graft failure in children receiving HLA-mismatched marrow transplants with busulfan-containing regimens.

Schultz KR and Ratanatharathorn V and Abella E and Eisenbrey AB and Karanes C and Lum LG and de Planque MM and Uberti JP and Ravindranath Y and Sensenbrenner LL

PubMed: 7920320

06 / 1994

Coactivation with anti-CD28 monoclonal antibody enhances anti-CD3 monoclonal antibody-induced proliferation and IL-2 synthesis in T cells from autologous bone marrow transplant recipients.

Lum LG and Joshi ID and Galoforo SC and Abella E and Karanes C and Ratanatharathorn V and Schultz KR and Uberti JP and Sensenbrenner LL and Ledbetter JA

PubMed: 8136739

12 / 1993

An increased relative frequency of retinoblastoma at a rural regional referral hospital in Miraj, Maharashtra, India

Cancer

Kirk R. Schultz and Shashi Ranade and Joseph P. Neglia and Yaddanapudi Ravindranath

DOI: 10.1002/1097-0142(19930701)72:1u003C282::aid-cncr2820720149u003E3.0.co;2-a

07 / 1993

Busulfan-based regimens and allogeneic bone marrow transplantation in patients with myelodysplastic syndromes.

Ratanatharathorn V and Karanes C and Uberti J and Lum LG and de Planque MM and Schultz KR and Cronin S and Dan ME and Mohamed A and Hussein M

PubMed: 8471779

04 / 1993

Effect of interleukin-2 on biodistribution of monoclonal antibody in tumor and normal tissues in mice bearing SL-2 thymoma.

Schultz KR and Badger CC and Dombi GW and Greenberg PD and Bernstein ID

DOI: 10.1093/jnci/84.2.109 PubMed: 1735876

01 / 1992

Allogeneic bone marrow transplantation in high-risk myeloid disorders using busulfan, cytosine arabinoside and cyclophosphamide (BAC).

Ratanatharathorn V and Karanes C and Lum LG and Uberti J and Dan ME and de Planque MM and Schultz KR and Cronin S and Leisz MC and Mohamed A

PubMed: 1543949

01 / 1992

Monoclonal antibody therapy of murine lymphoma: enhanced efficacy by concurrent administration of interleukin 2 or lymphokine-activated killer cells.

Schultz KR and Klarnet JP and Peace DJ and Cheever MA and Badger CC and Bernstein ID and Greenberg PD

PubMed: 2386946

09 / 1990

The role of B cells for in vivo T cell responses to a Friend virus-induced leukemia.

Schultz KR and Klarnet JP and Gieni RS and HayGlass KT and Greenberg PD

DOI: 10.1126/science.2118273 PubMed: 2118273

08 / 1990

IL-4-induced lymphokine-activated killer cells. Lytic activity is mediated by phenotypically distinct natural killer-like and T cell-like large granular lymphocytes.

Peace DJ and Kern DE and Schultz KR and Greenberg PD and Cheever MA

PubMed: 2896213

05 / 1988

Pathophysiology of Chronic Graft versus Host Disease

Chronic Graft Versus Host Disease

Kirk R. Schultz

DOI: 10.1017/cbo9780511576751.004

Current Projects

My work has evaluated clinically driven issues related to hematopoietic cell transplantation. Clinical investigations have focused on age-related factors affecting graft-versus-host disease (GVHD), graft-failure and graft-versus-leukemia (GVL). Laboratory investigations have used pre-clinical models and the performance of correlative studies in humans to investigate the mechanisms of GVHD and GVL and to develop experimental approaches to modulate these phenomena.

Our laboratory has evaluated the hypothesis that manipulation of MHC class II antigen presentation can alter T cell responses to endogenous antigens. We have investigated the importance of two MHC class II antigen presenting cells in vivo, B cells and dendritic cells, for T cell priming responses to leukemia, and minor histocompatibility antigens (MiHC). We have also investigated whether inhibition of MHC class II antigen presentation by lysosomotropic agents such as chloroquine can inhibit T cell responses to MiHC and development of GVHD. We have translated these pre-clinical observations into clinical studies. We have been one of the first groups to identify chronic GVHD biomarkers in children.

We are also investigating approaches to increasing T cell responses to leukemia by immunization approaches focused on overcoming defects in antigen presentation of endogenous antigens that are either specific to the malignancy or over-expressed in the malignancy. We have focused on the ability of all cells to act as antigen presenting cells and utilizing TLR agonists that affect both leukemic cell immunogenicity and anti-leukemia immune response.

I have been very involved in developing clinical trials focused on improving therapy for GVHD and Acute Lymphoblastic Leukemia. I am a prominent member of clinical co-operative groups including the Children’s Oncology Group (COG), Canadian Blood and Marrow Transplantation Group (CBMTG), Chronic GHVD Consensus Group (NIH sponsored), and C17 (a Canadian pediatric oncology research group). I am currently the group chair of the Pediatric BMT Consortium, a cooperative group that includes over 85 pediatric BMT centers in North America, Australia and New Zealand.

Honours & Awards

Election to Fellowship in the Canadian Academy of Health Sciences (CAHS) – 2014

Canadian National Transplant Research Program, CIHR and Genome BC – 2013

Geoffrey L. Hammond Lectureship Award, CFRI Member Recognition Awards – 2013

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