Michael Hayden

Pridopidine, a Potent and Selective Therapeutic Sigma-1 Receptor (S1R) Agonist for Treating Neurodegenerative Diseases

Pharmaceuticals

Noga Gershoni Emek and Andrew M. Tan and Michal Geva and Andrea Fekete and Carmen Abate and Michael R. Hayden

12 / 2025

Antidopaminergic Medications and Clinical Changes in Measures of Huntington's Disease: A Causal Analysis

Movement Disorders

Geva, M. and Goldberg, Y.P. and Schuring, H. and Tan, A.M. and Long, J.D. and Hayden, M.R.

The Safety Profile of Pridopidine, a Novel Sigma-1 Receptor Agonist for the Treatment of Huntingtons Disease

CNS Drugs

Goldberg, Y.P. and Navon-Perry, L. and Cruz-Herranz, A. and Chen, K. and Hecker-Barth, G. and Spiegel, K. and Cohen, Y. and Niethammer, M. and Tan, A.M. and Schuring, H. and Geva, M. and Hayden, M.R.

Antidopaminergic medications in Huntington's disease

Journal of Huntington's disease

Tan, A.M. and Geva, M. and Goldberg, Y.P. and Schuring, H. and Sanson, B.-J. and Rosser, A. and Raymond, L. and Reilmann, R. and Hayden, M.R. and Anderson, K.

Pridopidine in early-stage manifest Huntingtons disease: a phase 3 trial

Nature Medicine

Reilmann, R. and Feigin, A. and Rosser, A.E. and Kostyk, S.K. and Saft, C. and Cohen, Y. and Schuring, H. and Hand, R. and Tan, A.M. and Chen, K. and Feng, W. and Navon-Perry, L. and Cruz-Herranz, A. and Syltevik, C. and Boot, D. and Squitieri, F. and Kayson, E. and Mehra, M. and Goldberg, Y.P. and Geva, M. and Hayden, M.R.

Reduced Palmitoylation of SQSTM1/p62 in Huntington Disease Is Associated With Impaired Autophagy

FASEB Journal

Abrar, F. and Davies, M.C. and Alshehabi, Y. and Kumar, A. and Dang, A. and Nguyen, Y.T.N. and Collins, J. and Caron, N.S. and Choudhary, J.S. and Sanders, S.S. and Collins, M.O. and Hayden, M.R. and Martin, D.D.O.

Optimization of adeno-associated viral (AAV) gene therapies vectors for balancing efficacy, longevity and safety for clinical application

Gene Therapy

Mehta, N. and Gilbert, R. and Chahal, P.S. and Moreno, M.J. and Nassoury, N. and Coulombe, N. and Gingras, R. and Mullick, A. and Drouin, S. and Sasseville, M. and Latawa, J. and Tiwari, K. and Lin, W. and Harvey, E.M. and Miao, F. and Ross, C.J.D. and Hayden, M.R.

Molecular and imaging biomarker responses to brain mutant HTT lowering in a mouse model of Huntington disease

Molecular Therapy Nucleic Acids

Caron, N.S. and Fan, J. and Ma, D. and Yung, A. and Ko, S. and Bale, K. and Anderson, C. and Kozlowski, P. and Pouladi, M.A. and Wellington, C.L. and Hayden, M.R.

The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice

Journal of Lipid Research

Monteiro-Cardoso, V.F. and Yeo, X.Y. and Bae, H.-G. and Mayan, D.C. and Wehbe, M. and Lee, S. and Kumar Krishna, K. and Baek, S.H. and Palomera, L.F. and Wu, L.H. and Pakkiri, L.S. and Shanmugam, S. and Sem, K.P. and Yew, M.G. and Parsons, M.P. and Hayden, M.R. and Yeo, L.L.L. and Sharma, V.K. and Drum, C. and Liehn, E.A. and Sajikumar, S. and Davanger, S. and Jo, D.-G. and Chan, M.Y.Y. and Tan, B.Y.Q. and Jung, S. and Singaraja, R.R.

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification

Biomarker Research

Harding, R.J. and Xie, Y. and Caron, N.S. and Findlay-Black, H. and Lyu, C. and Potluri, N. and Chandrasekaran, R. and Hayden, M.R. and Leavitt, B.R. and Langbehn, D.R. and Southwell, A.L.

Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial

JAMA

Shefner, J.M. and Oskarsson, B. and Macklin, E.A. and Chibnik, L.B. and Quintana, M. and Saville, B.R. and Detry, M.A. and Vestrucci, M. and Marion, J. and Mcglothlin, A. and Heiman-Patterson, T. and Chase, M. and Pothier, L. and Harkey, B.A. and Yu, H. and Sherman, A.V. and Hall, M. and Kittle, G. and Berry, J.D. and Babu, S. and Andrews, J. and D{'}agostino, D. and Tustison, E. and Scirocco, E. and Giacomelli, E. and Alameda, G. and Locatelli, E. and Ho, D. and Quick, A. and Ajroud-Driss, S. and Katz, J. and Heitzman, D. and Appel, S.H. and Shroff, S. and Felice, K. and Maragakis, N.J. and Simmons, Z. and Miller, T.M. and Olney, N. and Weiss, M.D. and Goutman, S.A. and Fernandes, J.A. and Jawdat, O. and Owegi, M.A. and Foster, L.A. and Vu, T. and Ilieva, H. and Newman, D.S. and Arcila-Londono, X. and Jackson, C.E. and Ladha, S. and Caress, J.B. and Swenson, A. and Peltier, A. and Lewis, R.A. and Fee, D. and Elliott, M. and Bedlack, R. and Kasarskis, E.J. and Elman, L. and Rosenfeld, J. and Walk, D. and Mcilduff, C. and Twydell, P. and Young, E. and Johnson, K. and Rezania, K. and Goyal, N.A. and Cohen, J.A. and Benatar, M. and Jones, V. and Shah, J. and Beydoun, S.R. and Wymer, J.P. and Zilliox, L. and Nayar, S. and Pattee, G.L. and Martinez-Thompson, J. and Leitner, M.L. and Chen, K. and Goldberg, Y.P. and Cohen, Y. and Geva, M. and Hayden, M.R. and Paganoni, S. and Cudkowicz, M.E.

CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models

Molecular Therapy Nucleic Acids

Surdyka, M. and Kalinowska-Po?ka and Niewiadomska-Cimicka, A. and Jesion, E. and Fiszer, A. and Singer-Mikosch, E. and Fievet, L. and Przybyl, L. and Caron, N.S. and Hayden, M.R. and Nguyen, H.P. and Trottier, Y. and Figiel, M.

Towards Standardizing Nomenclature in Huntington's Disease Research

Journal of Huntington's Disease

Difiglia, M. and Leavitt, B.R. and MacDonald, D. and Thompson, L.M. and Bates, G.P. and Cha, J.-H. and Faull, R. and Feigin, A. and Gantman, E.C. and Gusella, J.F. and Hayden, M. and Housman, D. and Howland, D. and Langbehn, D. and Landwehrmeyer, B.G. and Long, J.D. and MacDonald, M. and Noble, S. and Rosser, A.E. and Sampaio, C. and Tabrizi, S. and Vonsattel, J.P. and Wanker, E.E. and Yang, X.W. and Yohrling, G. and Zeitlin, S.

Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study

The Lancet Neurology

Reilmann, R. and Anderson, K.E. and Feigin, A. and Tabrizi, S.J. and Leavitt, B.R. and Stout, J.C. and Piccini, P. and Schubert, R. and Loupe, P. and Wickenberg, A. and Borowsky, B. and Rynkowski, G. and Volkinshtein, R. and Li, T. and Savola, J.-M. and Hayden, M. and Gordon, M.F. and Guttman, M. and Raymond, L. and Mendis, T. and Suchowersky, O. and Corey-Bloom, J. and Geschwind, M.D. and Marshall, F.J. and Marder, K.S. and Nance, M. and Racette, B. and Bang, J. and Segro, V. and McDonell, K. and Kamholz, J. and LeDoux, M.S. and Sanchez-Ramos, J. and DeMichele, G. and Mariotti, C. and Squitieri, F. and Soliveri, P. and Cortelli, P. and Muoz Garca, J.E. and Kulisevsky Bojarski, J. and Lpez-Sendn Moreno, J.L. and Berganzo Corrales, K. and Cubo, E. and Garca Moreno, J.M. and Orth, M. and Priller, J. and Saft, C. and Weindl, A. and Winkler, J. and Craufurd, D. and Miedzybrodzka, Z. and Rickards, H. and Davies, R.R. and Lahiri, N. and Ruddy, D. and Komati, S.K. and Quarrell, O.W.J. and Correira Guedes, L. and Roos, R.A.C. and Zalyalova, Z. and Illarioshkin, S. and Gustov, A. and Klempir, J.

Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease

Neurobiology of Disease

Bartl, S. and Xie, Y. and Potluri, N. and Kesineni, R. and Hencak, K. and Cengio, L.D. and Balazs, K. and Oueslati, A. and Parth, M. and Salhat, N. and Siddu, A. and Smrzka, O. and Cicchetti, F. and Straffler, G. and Hayden, M.R. and Southwell, A.L.

Multicenter expanded access program for access to investigational products for amyotrophic lateral sclerosis

Muscle and Nerve

Neel, D.V. and Baselga-Garriga, C. and Benson, M. and Keegan, M. and Chase, M. and D'Agostino, D. and Drake, K. and Hagar, J.L. and Hasenoehrl, M.G. and Kulesa-Kelley, J. and Leite, A. and Mohapatra, S. and Portaro, S.M. and Pothier, L.M. and Rosenthal, J. and Sherman, A.V. and Yu, H. and McCaffrey, A. and Ho, D. and Luppino, S. and Bedlack, R. and Heitzman, D. and Ajroud-Driss, S. and Katz, J. and Felice, K. and Whitaker, C. and Ladha, S. and Alameda, G. and Locatelli, E. and Qureshi, I.A. and Hotchkin, M.T. and Hayden, M.R. and Cudkowicz, M.E. and Babu, S. and Berry, J.D. and Paganoni, S.

Plasma and CSF neurofilament light chain are stabilized in response to mutant huntingtin lowering in the brain of Huntington disease mice

Research Square

Caron, N.S. and Byrne, L.M. and Lemari, F.L. and Bone, J.N. and Aly, A.E.-E. and Ko, S. and Anderson, C. and Casal, L. and Hill, A.M. and Hawellek, D.J. and McColgan, P. and Wild, E.J. and Leavitt, B.R. and Hayden, M.R.

Corrigendum to Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease [Neurobiology of Disease, 2024 Jan:190:106376] (Neurobiology of Disease (2024) 190, (S0969996123003923), (10.1016/j.nbd.2023.106376))

Neurobiology of Disease

Bartl, S. and Xie, Y. and Potluri, N. and Kesineni, R. and Hencak, K. and Cengio, L.D. and Balazs, K. and Oueslati, A. and Parth, M. and Salhat, N. and Siddu, A. and Smrzka, O. and Cicchetti, F. and Staffler, G. and Hayden, M.R. and Southwell, A.L.

Ascertainment of uninterrupted CAG repeat length and disease-modifying variants in fragment-based genetic testing for Huntington Disease

Genetics in Medicine Open

Findlay Black, H. and Kay, C. and Dawson, J. and Bortnick, S. and Javier, K. and Xia, Q. and Chau, C.H. and Leavitt, T. and Arning, L. and Nguyen, H.P. and Hayden, M.R.

Identification of neurodevelopmental organization of the cell populations of juvenile Huntington's disease using dorso-ventral HD organoids and HD mouse embryos

bioRxiv

?wito?ska-Kurkowska, K. and Kubi?, J. and Delimata-Raczek, J. and Krist, B. and Surdyka, M. and Kalinowska-Po?ka, ?. and Piasecki, P. and Handschuh, L. and Podkowi?ski, J. and Rakoczy, M. and Samelak-Czajka, A. and Hayden, M. and Caron, N.S. and Figiel, M.

Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease

Journal of Controlled Release

Caron, N.S. and Aly, A.E.-E. and Findlay Black, H. and Martin, D.D.O. and Schmidt, M.E. and Ko, S. and Anderson, C. and Harvey, E.M. and Casal, L.L. and Anderson, L.M. and Rahavi, S.M.R. and Reid, G.S.D. and Oda, M.N. and Stanimirovic, D. and Abulrob, A. and McBride, J.L. and Leavitt, B.R. and Hayden, M.R.

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models

Brain

Sogorb-Gonzalez, M. and Landles, C. and Caron, N.S. and Stam, A. and Osborne, G. and Hayden, M.R. and Howland, D. and Van Deventer, S. and Bates, G.P. and Valls, A. and Evers, M.

Opportunities and challenges for innovative and equitable healthcare

Nature Reviews Drug Discovery

Ecker, D.J. and Aiello, C.D. and Arron, J.R. and Bennett, C.F. and Bernard, A. and Breakefield, X.O. and Broderick, T.J. and Callier, S.L. and Canton, B. and Chen, J.S. and Fishburn, C.S. and Garrett, B. and Hecht, S.M. and Janowitz, T. and Kliegman, M. and Krainer, A. and Louis, C.U. and Lowe, C. and Sehgal, A. and Tozan, Y. and Tracey, K.J. and Urnov, F. and Wattendorf, D. and Williams, T.W. and Zhao, X. and Hayden, M.R.

Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntingtons disease mice

Translational Neurodegeneration

Caron, N.S. and Byrne, L.M. and Lemari, F.L. and Bone, J.N. and Aly, A.E.E. and Ko, S. and Anderson, C. and Casal, L.L. and Hill, A.M. and Hawellek, D.J. and McColgan, P. and Wild, E.J. and Leavitt, B.R. and Hayden, M.R.

The frequency and clinical impact of synonymous HTT loss-of-interruption and duplication-of-interruption variants in a diverse HD cohort

Genetics in Medicine

Dawson, J. and Kay, C. and Black, H.F. and Bortnick, S. and Javier, K. and Xia, Q. and Sandhu, A. and Buchanan, C. and Hogg, V. and Chang, F.C.F. and Goto, J. and Arning, L. and Saft, C. and Bijlsma, E.K. and Nguyen, H.P. and Roxburgh, R. and Hayden, M.R.

Expanded access protocol (EAP) program for access to investigational products for amyotrophic lateral sclerosis (ALS).

Muscle & nerve

Yerton M and Winter A and Gelevski D and Addy G and Kostov A and Lieberman C and Weber H and Doyle M and Kane G and Caroline Cohen and Parikh N and Katherine M Burke and Rohrer M and Stirrat T and Bruno M and Hochman A and Luppino S and Scalia J and D'Agostino D and Sinani E and Yu H and Drake K and Hagar J and Sherman AV and Babu S and James D. Berry and Merit Cudkowicz and Sabrina Paganoni

04 / 2023

Axonal ER Ca²⁺ Release Selectively Enhances Activity-Independent Glutamate Release in a Huntington Disease Model.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Mackay JP and Smith-Dijak AI and Koch ET and Zhang P and Fung E and Nassrallah WB and Buren C and Schmidt M and Michael R. Hayden and Lynn Raymond

03 / 2023

Pridopidine Does Not Significantly Prolong the QTc Interval at the Clinically Relevant Therapeutic Dose.

Neurology and therapy

Darpo B and Michal Geva and Ferber G and Goldberg YP and Cruz-Herranz A and Mehra M and Kovacs R and Michael R. Hayden

02 / 2023

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety EvaluationS

Journal of Pharmacology and Experimental Therapeutics

Cutts, A. and Chowdhury, S. and Ratkay, L.G. and Eyers, M. and Young, C. and Namdari, R. and Cadieux, J.A. and Chahal, N. and Grimwood, M. and Zhang, Z. and Lin, S. and Tietjen, I. and Xie, Z. and Robinette, L. and Sojo, L. and Waldbrook, M. and Hayden, M. and Mansour, T. and Pimstone, S. and Paul Goldberg, Y. and Webb, M. and Cohen, C.J.

Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage

Frontiers in Physiology

Lemari{\'e}, F.L. and Sanders, S.S. and Nguyen, Y. and Martin, D.D.O. and Hayden, M.R.

Limitations of Dual-Single Guide RNA CRISPR Strategies for the Treatment of Central Nervous System Genetic Disorders

Human Gene Therapy

Duarte, F. and Vachey, G. and Caron, N.S. and Sipion, M. and Rey, M. and Perrier, A.L. and Hayden, M.R. and Dglon, N.

Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks

Journal of Controlled Release

Aly, A.E.-E. and Caron, N.S. and Black, H.F. and Schmidt, M.E. and Anderson, C. and Ko, S. and Baddeley, H.J.E. and Anderson, L. and Casal, L.L. and Rahavi, R.S.M. and Martin, D.D.O. and Hayden, M.R.

Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease

Antioxidants and Redox Signaling

F{\~a}o, L. and Coelho, P. and Duarte, L. and Vila?a, R. and Hayden, M.R. and Mota, S.I. and Rego, A.C.

Preclinical Development and Characterization of Novel Adeno-Associated Viral Vectors for the Treatment of Lipoprotein Lipase Deficiency

Human Gene Therapy

Mehta, N. and Gilbert, R. and Chahal, P.S. and Moreno, M.J. and Nassoury, N. and Coulombe, N. and Lytvyn, V. and Mercier, M. and Fatehi, D. and Lin, W. and Harvey, E.M. and Zhang, L.-H. and Nazemi-Moghaddam, N. and Elahi, S.M. and Ross, C.J.D. and Stanimirovic, D.B. and Hayden, M.R.

Allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models

BMC Biology

Joachimiak, P. and Ciesio?ka, A. and Koz?owska, E. and ?wito?ski, P.M. and Figura, G. and Cio?ak, A. and Adamek, G. and Surdyka, M. and Kalinowska-Po?ka, ?. and Figiel, M. and Caron, N.S. and Hayden, M.R. and Fiszer, A.

A PET-CT study on neuroinflammation in Huntington's disease patients participating in a randomized trial with laquinimod

Brain Communications

Roussakis, A.-A. and Gennaro, M. and Gordon, M.F. and Reilmann, R. and Borowsky, B. and Rynkowski, G. and Lao-Kaim, N.P. and Papoutsou, Z. and Savola, J.-M. and Hayden, M.R. and Owen, D.R. and Kalk, N. and Lingford-Hughes, A. and Gunn, R.N. and Searle, G. and Tabrizi, S.J. and Piccini, P.

Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice

Aging and Disease

Van Raamsdonk, J.M. and Al-Shekaili, H.H. and Wagner, L. and Bredy, T.W. and Chan, L. and Pearson, J. and Schwab, C. and Murphy, Z. and Devon, R.S. and Lu, G. and Kobor, M.S. and Hayden, M.R. and Leavitt, B.R.

Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy

bioRxiv

Abrar, F. and Davies, M.C. and Kumar, A. and Dang, A. and Nguyen, Y.T.N. and Collins, J. and Caron, N. and Choudhary, J.S. and Sanders, S.S. and Collins, M.O. and Hayden, M.R. and Martin, D.D.O.

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

Autophagy

Wang, S.-M. and Wu, H.-E. and Yasui, Y. and Geva, M. and Hayden, M. and Maurice, T. and Cozzolino, M. and Su, T.-P.

Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models

Journal of Huntington's Disease

Chan, L.L. and Hill, A. and Lu, G. and Van Raamsdonk, J. and Gascoyne, R. and Hayden, M.R. and Leavitt, B.R.

Huntingtin Over-Expression Does Not Alter Overall Survival in Murine Cancer Models

bioRxiv

Chan, L. and Hill, A. and Lu, G. and Van Raamsdonk, J. and Gascoyne, R.D. and Hayden, M.R. and Leavitt, B.R.

Huntingtin expression influences spontaneous seizure disorder susceptibility in FVN/B mice

bioRxiv

Van Raamsdonk, J.M. and Al-Shekeli, H. and Wagner, L. and Bredy, T.W. and Chan, L. and Pearson, J. and Schwab, C. and Murphy, Z. and Devon, R.S. and Lu, G. and Kobor, M.S. and Hayden, M.R. and Leavitt, B.R.

Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity

Brain Communications

Caron, N.S. and Haqqani, A.S. and Sandhu, A. and Aly, A.E. and Findlay Black, H. and Bone, J.N. and Mcbride, J.L. and Abulrob, A. and Stanimirovic, D. and Leavitt, B.R. and Hayden, M.R.

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation

bioRxiv

Cutts, A. and Chowdhury, S. and Ratkay, L.G. and Eyers, M. and Young, C. and Namdari, R. and Cadieux, J.A. and Chahal, N. and Grimwood, M. and Zhang, Z. and Lin, S. and Tietjen, I. and Xie, Z. and Robinette, L. and Sojo, L. and Waldbrook, M. and Hayden, M. and Mansour, T. and Pimstone, S. and Goldberg, Y.P. and Webb, M. and Cohen, C.J.

Mitochondrial and redox modifications in early stages of Huntington's disease

Redox Biology

Lopes, C. and Ferreira, I.L. and Maranga, C. and Beatriz, M. and Mota, S.I. and Sereno, J. and Castelhano, J. and Abrunhosa, A. and Oliveira, F. and De Rosa, M. and Hayden, M. and La?o, M.N. and Janurio, C. and Castelo Branco, M. and Rego, A.C.

Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model

Neurobiology of Disease

Lenoir, S. and Lahaye, R.A. and Vitet, H. and Scaramuzzino, C. and Virlogeux, A. and Capellano, L. and Genoux, A. and Gershoni-Emek, N. and Geva, M. and Hayden, M.R. and Saudou, F.

Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans

Journal of Clinical Investigation

Zhong, S. and Ch{\`e}vre, R. and Mayan, D.C. and Corlian{\`o}, M. and Cochran, B.J. and Sem, K.P. and van Dijk, T.H. and Peng, J. and Tan, L.J. and Hartimath, S.V. and Ramasamy, B. and Cheng, P. and Groen, A.K. and Kuipers, F. and Goggi, J.L. and Drum, C. and van Dam, R.M. and Tan, R.S. and Rye, K.-A. and Hayden, M.R. and Cheng, C.-Y. and Chacko, S. and Flannick, J. and Sim, X. and Tan, H.C. and Singaraja, R.R.

Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice

Neurobiology of Disease

Caron, N.S. and Banos, R. and Aly, A.E. and Xie, Y. and Ko, S. and Potluri, N. and Anderson, C. and Black, H.F. and Anderson, L.M. and Gordon, B. and Southwell, A.L. and Hayden, M.R.

Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice

bioRxiv

Monteiro-Cardoso, V.F. and Yeo, X.Y. and Bae, H.-G. and Mayan, D.C. and Wehbe, M. and Lee, S. and Kumar Krishna, K. and Baek, S.H. and Palomera, L.F. and Shanmugam, S. and Sem, K.P. and Parsons, M.P. and Hayden, M.R. and Liehn, E.A. and Sajikumar, S. and Davanger, S. and Jo, D.-G. and Jung, S. and Singaraja, R.R.

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity

Fanny L. Lemari and Nicholas S. Caron and Shaun S. Sanders and Mandi E. Schmidt and Yen T.N. Nguyen and Seunghyun Ko and Xiaohong Xu and Mahmoud A. Pouladi and Dale D.O. Martin and Michael R. Hayden

03 / 2021

Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study

European Journal of Nuclear Medicine and Molecular Imaging

Grachev, I.D. and Meyer, P.M. and Becker, G.A. and Bronzel, M. and Marsteller, D. and Pastino, G. and Voges, O. and Rabinovich, L. and Knebel, H. and Zientek, F. and Rullmann, M. and Sattler, B. and Patt, M. and Gerhards, T. and Strauss, M. and Kluge, A. and Brust, P. and Savola, J.-M. and Gordon, M.F. and Geva, M. and Hesse, S. and Barthel, H. and Hayden, M.R. and Sabri, O.

The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models

Neurotherapeutics

Naia, L. and Ly, P. and Mota, S.I. and Lopes, C. and Maranga, C. and Coelho, P. and Gershoni-Emek, N. and Ankarcrona, M. and Geva, M. and Hayden, M.R. and Rego, A.C.

Sigma-1 receptor (S1r) interaction with cholesterol: Mechanisms of s1r activation and its role in neurodegenerative diseases

International Journal of Molecular Sciences

Zhemkov, V. and Geva, M. and Hayden, M.R. and Bezprozvanny, I.

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

Scientific Reports

Geva, M. and Gershoni-Emek, N. and Naia, L. and Ly, P. and Mota, S. and Rego, A.C. and Hayden, M.R. and Levin, L.A.

Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting

Journal of Huntington's Disease

Caron, N.S. and Anderson, C. and Black, H.F. and Sanders, S.S. and Lemari, F.L. and Doty, C.N. and Hayden, M.R.

Mutant huntingtin is cleared from the brain via active mechanisms in huntington disease

Journal of Neuroscience

Caron, N.S. and Banos, R. and Yanick, C. and Aly, A.E. and Byrne, L.M. and Smith, E.D. and Xie, Y. and Smith, S.E.P. and Potluri, N. and Black, H.F. and Casal, L. and Ko, S. and Cheung, D. and Kim, H. and Seong, I.S. and Wild, E.J. and Song, J.-J. and Hayden, M.R. and Southwell, A.L.

Small molecule splicing modifiers with systemic HTT-lowering activity

Nature Communications

Bhattacharyya, A. and Trotta, C.R. and Narasimhan, J. and Wiedinger, K.J. and Li, W. and Effenberger, K.A. and Woll, M.G. and Jani, M.B. and Risher, N. and Yeh, S. and Cheng, Y. and Sydorenko, N. and Moon, Y.-C. and Karp, G.M. and Weetall, M. and Dakka, A. and Gabbeta, V. and Naryshkin, N.A. and Graci, J.D. and Tripodi, T. and Southwell, A. and Hayden, M. and Colacino, J.M. and Peltz, S.W.

Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor

Journal of Neurochemistry

Shenkman, M. and Geva, M. and Gershoni-Emek, N. and Hayden, M.R. and Lederkremer, G.Z.

Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice

Neurobiology of Disease

Ravalia, A.S. and Lau, J. and Barron, J.C. and Purchase, S.L.M. and Southwell, A.L. and Hayden, M.R. and Nafar, F. and Parsons, M.P.

Additional Safety and Exploratory Efficacy Data at 48 and 60 Months from Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease

Journal of Huntington's Disease

Andrew McGarry and Peggy Auinger and Karl Kieburtz and Michal Geva and Munish Mehra and Victor Abler and Igor D. Grachev and Mark Forrest Gordon and Juha-Matti Savola and Sanjay Gandhi and Spyridon Papapetropoulos and Michael Hayden

06 / 2020

Effect of Pridopidine in Huntington Disease (HD) Patients and Healthy Volunteers (HVs) " A Simultaneous Sigma-1 Receptor PET/Multimodality MRI Study

58. Jahrestagung der Deutschen Gesellschaft fr Nuklearmedizin

H Barthel and PM Meyer and M Rullmann and G Becker and M Bronzel and D Marsteller and O Voges and F Zientek and B Sattler and M Patt and E Strauss and A Kluge and JM Savola and MF Gordon and M Geva and S Hesse and M Hayden and ID Grachev and O Sabri

04 / 2020

High sigma-1 receptor (S1R) and very low dopamine 2/dopamine 3 receptor (D2/D3R) occupancy at clinically relevant doses of pridopidine in healthy volunteers (HV) and Huntington disease patients (HD): a F-18-Fluspidine and F-18-Fallypride PET study

58. Jahrestagung der Deutschen Gesellschaft fr Nuklearmedizin

PM Meyer and ID Grachev and GA Becker and M Bronzel and D Marsteller and O Voges and L Rabinovich and F Zientek and M Rullmann and B Sattler and M Patt and E Strauss and A Kluge and JM Savola and MF Gordon and M Geva and S Hesse and H Barthel and M Hayden and O Sabri

04 / 2020

Axonal ER Ca2+ Release Enhances Miniature, but Reduces Activity-Dependent Glutamate Release in a Huntington Disease Model

Mackay JP and Smith-Dijak AI and Koch ET and Zhang P and Fung E and Nassrallah WB and Buren C and Schmidt M and Hayden MR and Raymond LA

01 / 2020

pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model

Cell Death and Disease

Xu, X. and Ng, B. and Sim, B. and Radulescu, C.I. and Yusof, N.A.B.M. and Goh, W.I. and Lin, S. and Lim, J.S.Y. and Cha, Y. and Kusko, R. and Kay, C. and Ratovitski, T. and Ross, C. and Hayden, M.R. and Wright, G. and Pouladi, M.A.

Tracing the mutated HTT and haplotype of the African ancestor who spread Huntington disease into the Middle East

Genetics in Medicine

Squitieri, F. and Mazza, T. and Maffi, S. and De Luca, A. and AlSalmi, Q. and AlHarasi, S. and Collins, J.A. and Kay, C. and Baine-Savanhu, F. and Landwhermeyer, B.G. and Sabatini, U. and Hayden, M.R.

Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range

Genetics in Medicine

Findlay Black, H. and Wright, G.E.B. and Collins, J.A. and Caron, N. and Kay, C. and Xia, Q. and Arning, L. and Bijlsma, E.K. and Squitieri, F. and Nguyen, H.P. and Hayden, M.R.

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease

Nucleic Acids Research

Caron, N.S. and Southwell, A.L. and Brouwers, C.C. and Cengio, L.D. and Xie, Y. and Black, H.F. and Anderson, L.M. and Ko, S. and Zhu, X. and Van Deventer, S.J. and Evers, M.M. and Konstantinova, P. and Hayden, M.R.

Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17

Cell Reports

Niu, J. and Sanders, S.S. and Jeong, H.-K. and Holland, S.M. and Sun, Y. and Collura, K.M. and Hernandez, L.M. and Huang, H. and Hayden, M.R. and Smith, G.M. and Hu, Y. and Jin, Y. and Thomas, G.M.

Compromised IGF signaling causes caspase-6 activation in Huntington disease

Experimental Neurology

Skotte, N.H. and Pouladi, M.A. and Ehrnhoefer, D.E. and Huynh, K. and Qiu, X. and Nielsen, S.M.B. and Nielsen, T.T. and N?rrem?lle, A. and Hayden, M.R.

Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease

Neurobiology of Disease

Bartl, S. and Oueslati, A. and Southwell, A.L. and Siddu, A. and Parth, M. and David, L.S. and Maxan, A. and Salhat, N. and Burkert, M. and Mairhofer, A. and Friedrich, T. and Pankevych, H. and Balazs, K. and Staffler, G. and Hayden, M.R. and Cicchetti, F. and Smrzka, O.W.

Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study

Journal of Huntington's Disease

McGarry, A. and Leinonen, M. and Kieburtz, K. and Geva, M. and Olanow, C.W. and Hayden, M.

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of huntington disease

Human Molecular Genetics

Wright, G.E.B. and Caron, N.S. and Ng, B. and Casal, L. and Casazza, W. and Xu, X. and Ooi, J. and Pouladi, M.A. and Mostafavi, S. and Ross, C.J.D. and Hayden, M.R.

DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease

Frontiers in Cellular Neuroscience

Schmidt, M.E. and Caron, N.S. and Aly, A.E. and Lemari, F.L. and Dal Cengio, L. and Ko, Y. and Lazic, N. and Anderson, L. and Nguyen, B. and Raymond, L.A. and Hayden, M.R.

Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies

The Lancet Neurology

Wright, G.E.B. and Black, H.F. and Collins, J.A. and Gall-Duncan, T. and Caron, N.S. and Pearson, C.E. and Hayden, M.R.

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

Frontiers in Aging Neuroscience

Machiela, E. and Jeloka, R. and Caron, N.S. and Mehta, S. and Schmidt, M.E. and Baddeley, H.J.E. and Tom, C.M. and Polturi, N. and Xie, Y. and Mattis, V.B. and Hayden, M.R. and Southwell, A.L.

The interaction of aging and oxidative stress contributes to pathogenesis in mouse and human Huntington disease neurons

Emily Machiela and Ritika Jeloka and Nicholas S. Caron and Shagun Mehta and Mandi E. Schmidt and Colton M. Tom and Nalini Polturi and Yuanyun Xie and Virginia B Mattis and Michael R. Hayden and Amber L. Southwell

10 / 2019

Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease

American Journal of Human Genetics

Wright, G.E.B. and Collins, J.A. and Kay, C. and McDonald, C. and Dolzhenko, E. and Xia, Q. and Be?anovi?, K. and Drgemller, B.I. and Semaka, A. and Nguyen, C.M. and Trost, B. and Richards, F. and Bijlsma, E.K. and Squitieri, F. and Ross, C.J.D. and Scherer, S.W. and Eberle, M.A. and Yuen, R.K.C. and Hayden, M.R.

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

Neurobiology of Disease

Ryskamp, D. and Wu, L. and Wu, J. and Kim, D. and Rammes, G. and Geva, M. and Hayden, M. and Bezprozvanny, I.

Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes

Clinical Pharmacology and Therapeutics

Wright, G.E.B. and Amstutz, U. and Drgemller, B.I. and Shih, J. and Rassekh, S.R. and Hayden, M.R. and Carleton, B.C. and Ross, C.J.D. and Visscher, H. and Aminkeng, F. and Higginson, M. and Massah, N. and Miao, F. and Bhavsar, A. and Lee, J. and Bendyshe-Walton, T. and Tanoshima, R. and Johnson, D. and Zhuwaki, C. and Honcharik, N. and Jong, G. and Israels, S. and Staub, M. and Rieder, M. and Faught, L. and Ito, S. and Nathan, P. and Karande, S. and Vaillancourt, R. and Johnston, D. and Nguyen, K. and Bussires, J.-F. and Lebel, D. and Jean-Louis, J.

In search of a genetic explanation for LDLc variability in an FH family: Common SNPs and a rare mutation in MTTP explain only part of LDL variability in an FH family

Journal of Lipid Research

Winther, M. and Shpitzen, S. and Yaacov, O. and Landau, J. and Oren, L. and Foroozan-Rosenberg, L. and Cohain, N.L. and Schurr, D. and Meiner, V. and Szalat, A. and Carmi, S. and Hayden, M.R. and Leitersdorf, E. and Durst, R.

Altered regulation of striatal neuronal N-methyl-D-aspartate receptor trafficking by palmitoylation in Huntington disease mouse model

Frontiers in Synaptic Neuroscience

Kang, R. and Wang, L. and Sanders, S.S. and Zuo, K. and Hayden, M.R. and Raymond, L.A.

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1 G93A Model

Cell Death and Disease

Ionescu, A. and Gradus, T. and Altman, T. and Maimon, R. and Saraf Avraham, N. and Geva, M. and Hayden, M. and Perlson, E.

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinsons Disease

Neurotherapeutics

Francardo, V. and Geva, M. and Bez, F. and Denis, Q. and Steiner, L. and Hayden, M.R. and Cenci, M.A.

Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease

bioRxiv

Wright, G.E.B. and Collins, J.A. and Kay, C. and McDonald, C. and Dolzhenko, E. and Xia, Q. and Be?anovi?, K. and Semaka, A. and Nguyen, C.M. and Trost, B. and Richards, F. and Bijlsma, E.K. and Squitieri, F. and Scherer, S.W. and Eberle, M.A. and Yuen, R.K.C. and Hayden, M.R.

Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease

Molecular Neurobiology

Garcia-Miralles, M. and Yusof, N.A.B.M. and Tan, J.Y. and Radulescu, C.I. and Sidik, H. and Tan, L.J. and Belinson, H. and Zach, N. and Hayden, M.R. and Pouladi, M.A.

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

Proceedings of the National Academy of Sciences of the United States of America

Bardile, C.F. and Garcia-Miralles, M. and Caron, N.S. and Rayan, N.A. and Langley, S.R. and Harmston, N. and Rondelli, A.M. and Yi Teo, R.T. and Waltl, S. and Anderson, L.M. and Bae, H.-G. and Jung, S. and Williams, A. and Prabhakar, S. and Petretto, E. and Hayden, M.R. and Pouladi, M.A.

Impairment and restoration of homeostatic plasticity in cultured cortical neurons from a mouse model of huntington disease

Frontiers in Cellular Neuroscience

Smith-Dijak, A.I. and Nassrallah, W.B. and Zhang, L.Y.J. and Geva, M. and Hayden, M.R. and Raymond, L.A.

Clinical management of huntington's disease: The role of pet and dna linkage studies

Functional Imaging in Movement Disorders

Hayden, M.R. and Ammann, W.

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound

Cell Chemical Biology

Ehrnhoefer, D.E. and Skotte, N.H. and Reinshagen, J. and Qiu, X. and Windshgel, B. and Jaishankar, P. and Ladha, S. and Petina, O. and Khankischpur, M. and Nguyen, Y.T.N. and Caron, N.S. and Razeto, A. and Meyer zu Rheda, M. and Deng, Y. and Huynh, K.T. and Wittig, I. and Gribbon, P. and Renslo, A.R. and Geffken, D. and Gul, S. and Hayden, M.R.

Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices

Digital Biomarkers

Gordon, M.F. and Grachev, I.D. and Mazeh, I. and Dolan, Y. and Reilmann, R. and Loupe, P.S. and Fine, S. and Navon-Perry, L. and Gross, N. and Papapetropoulos, S. and Savola, J.-M. and Hayden, M.R.

A Comprehensive Haplotype-Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease

American Journal of Human Genetics

Kay, C. and Collins, J.A. and Caron, N.S. and Agostinho, L.D.A. and Findlay-Black, H. and Casal, L. and Sumathipala, D. and Dissanayake, V.H.W. and Cornejo-Olivas, M. and Baine, F. and Krause, A. and Greenberg, J.L. and Paiva, C.L.A. and Squitieri, F. and Hayden, M.R.

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques

Movement Disorders

Johnston, T.H. and Geva, M. and Steiner, L. and Orbach, A. and Papapetropoulos, S. and Savola, J.-M. and Reynolds, I.J. and Ravenscroft, P. and Hill, M. and Fox, S.H. and Brotchie, J.M. and Laufer, R. and Hayden, M.R.

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance

FASEB Journal

Martin, D.D.O. and Schmidt, M.E. and Nguyen, Y.T. and Lazic, N. and Hayden, M.R.

Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study

The Lancet Neurology

Reilmann, R. and McGarry, A. and Grachev, I.D. and Savola, J.-M. and Borowsky, B. and Eyal, E. and Gross, N. and Langbehn, D. and Schubert, R. and Wickenberg, A.T. and Papapetropoulos, S. and Hayden, M. and Squitieri, F. and Kieburtz, K. and Landwehrmeyer, G.B. and Agarwal, P. and Anderson, K.E. and Aziz, N.A. and Azulay, J.-P. and Bachoud-Levi, A.C. and Barker, R. and Bebak, A. and Beuth, M. and Biglan, K. and Blin, S. and Bohlen, S. and Bonelli, R. and Caldwell, S. and Calvas, F. and Carlos, J. and Castagliuolo, S. and Chong, T. and Chua, P. and Coleman, A. and Corey-Bloom, J. and Cousins, R. and Craufurd, D. and Davison, J. and Decorte, E. and De Michele, G. and Dornhege, L. and Feigin, A. and Gallehawk, S. and Gauteul, P. and Gonzales, C. and Griffith, J. and Gustov, A. and Guttman, M. and Heim, B. and Heller, H. and Hjermind, L. and Illarioshkin, S. and Ivanko, L. and Jaynes, J. and Jenckes, M. and Kaminski, B. and Kampstra, A. and Konkel, A. and Kopishinskaya, S. and Krystkowiak, P. and Komati, S.K. and Kwako, A. and Lakoning, S. and Latipova, G. and Leavitt, B. and Loy, C. and MacFarlane, C. and Madsen, L. and Marder, K. and Mason, S. and Mendis, N. and Mendis, T. and Nemeth, A. and Nevitt, L. and Norris, V. and O'Neill, C. and Olivier, A. and Orth, M. and Owens, A. and Panegyres, P. and Perlman, S. and Preston, J. and Priller, J. and Puch, A. and Quarrell, O. and Ragosta, D. and Rialland, A. and Rickards, H. and Romoli, A.M. and Ross, C. and Rosser, A. and Rudzinska, M. and Russo, C.V. and Saft, C. and Segro, V. and Seppi, K. and Shannon, B. and Shprecher, D. and Simonin, C. and Skitt, Z. and Slawek, J. and Soliveri, P. and Sorbi, S. and Suski, V. and Stepniak, I. and Sungmee, P. and Temirbaeva, S. and Testa, C. and Torvin-Moller, A. and Uhl, S. and Vangsted-Hansen, C. and Verny, C. and Wall, P. and Walker, F. and Wasserman, P. and Witkowski, G. and Wright, J. and Zalyalova, Z. and Zielonka, D.

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Neurobiology of Disease

Eddings, C.R. and Arbez, N. and Akimov, S. and Geva, M. and Hayden, M.R. and Ross, C.A.

Synaptopathy, circuitopathy and the computational biology of Huntington's disease.

BMC biology

06 / 2018

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

BMC Biology

Schmidt, M.E. and Buren, C. and Mackay, J.P. and Cheung, D. and Dal Cengio, L. and Raymond, L.A. and Hayden, M.R.

Therapeutic approaches to huntington disease: From the bench to the clinic

Nature Reviews Drug Discovery

Caron, N.S. and Dorsey, E.R. and Hayden, M.R.

Physicochemical, biological, functional and toxicological characterization of the European follow-on glatiramer acetate product as compared with Copaxone

eNeurologicalSci

Melamed-Gal, S. and Loupe, P. and Timan, B. and Weinstein, V. and Kolitz, S. and Zhang, J. and Funt, J. and Komlosh, A. and Ashkenazi, N. and Bar-Ilan, O. and Konya, A. and Beriozkin, O. and Laifenfeld, D. and Hasson, T. and Krispin, R. and Molotsky, T. and Papir, G. and Sulimani, L. and Zeskind, B. and Liu, P. and Nock, S. and Hayden, M.R. and Gilbert, A. and Grossman, I.

Genetic ablation of cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition

American Journal of Physiology - Endocrinology and Metabolism

Patankar, J.V. and Wong, C.K. and Morampudi, V. and Gibson, W.T. and Vallance, B. and Ioannou, G.N. and Hayden, M.R.

Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients

Clinical Cancer Research

Drogemoller, B.I. and Brooks, B. and Critchley, C. and Monzon, J.G. and Wright, G.E.B. and Liu, G. and Renouf, D.J. and Kollmannsberger, C.K. and Bedard, P.L. and Hayden, M.R. and Gelmon, K.A. and Carleton, B.C. and Ross, C.J.D.

The global spectrum of protein-coding pharmacogenomic diversity

Pharmacogenomics Journal

Wright, G.E.B. and Carleton, B. and Hayden, M.R. and Ross, C.J.D.

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Human Molecular Genetics

Ehrnhoefer, D.E. and Southwell, A.L. and Sivasubramanian, M. and Qiu, X. and Villanueva, E.B. and Xie, Y. and Waltl, S. and Anderson, L. and Fazeli, A. and Casal, L. and Felczak, B. and Tsang, M. and Hayden, M.R.

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease

Biochimica et Biophysica Acta - Molecular Basis of Disease

Silva, A.C. and Ferreira, I.L. and Hayden, M.R. and Ferreiro, E. and Rego, A.C.

Therapeutic modulation of the bile acid pool by cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice

FASEB Journal

Chevre, R. and Trigueros-Motos, L. and Castao, D. and Chua, T. and Corliano, M. and Patankar, J.V. and Sng, L. and Sim, L. and Juin, T.L. and Carissimo, G. and Ng, L.F.P. and Jia Yi, C.N. and Eliathamby, C.C. and Groen, A.K. and Hayden, M.R. and Singaraja, R.R.

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Molecular Neurodegeneration

Kusko, R. and Dreymann, J. and Ross, J. and Cha, Y. and Escalante-Chong, R. and Garcia-Miralles, M. and Tan, L.J. and Burczynski, M.E. and Zeskind, B. and Laifenfeld, D. and Pouladi, M. and Geva, M. and Grossman, I. and Hayden, M.R.

A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes

Human Molecular Genetics

Petrella, L.I. and Castelhano, J.M. and Ribeiro, M. and Sereno, J.V. and Gon?alves, S.I. and La?o, M.N. and Hayden, M.R. and Cristina Rego, A. and Castelo-Branco, M.

The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Kay, C. and Collins, J.A. and Wright, G.E.B. and Baine, F. and Miedzybrodzka, Z. and Aminkeng, F. and Semaka, A.J. and McDonald, C. and Davidson, M. and Madore, S.J. and Gordon, E.S. and Gerry, N.P. and Cornejo-Olivas, M. and Squitieri, F. and Tishkoff, S. and Greenberg, J.L. and Krause, A. and Hayden, M.R.

Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli

Cell Death Discovery

Ladha, S. and Qiu, X. and Casal, L. and Caron, N.S. and Ehrnhoefer, D.E. and Hayden, M.R.

A human huntingtin SNP alters post-Translational modification and pathogenic proteolysis of the protein causing Huntington disease

Scientific Reports

Martin, D.D.O. and Kay, C. and Collins, J.A. and Nguyen, Y.T. and Slama, R.A. and Hayden, M.R.

Response to the Letter-to-the Editor by Cohen et al. concerning our eNeurologicalSci article, Melamed-Gal, et al. Physicochemical, biological, functional and toxicological characterization of the European follow-on glatiramer acetate product as compared with Copaxone. eNeurologicalSci 2018;12:19"30.https://doi.org/10.1016/j.ensci.2018.05.006

eNeurologicalSci

Melamed-Gal, S. and Loupe, P. and Timan, B. and Weinstein, V. and Kolitz, S. and Zhang, J. and Funt, J. and Komlosh, A. and Ashkenazi, N. and Bar-Ilan, O. and Konya, A. and Beriozkin, O. and Laifenfeld, D. and Hasson, T. and Zeskind, B. and Hayden, M. and Nock, S. and Grossman, I.

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Acta neuropathologica communications

Ehrnhoefer, D.E. and Martin, D.D.O. and Schmidt, M.E. and Qiu, X. and Ladha, S. and Caron, N.S. and Skotte, N.H. and Nguyen, Y.T.N. and Vaid, K. and Southwell, A.L. and Engemann, S. and Franciosi, S. and Hayden, M.R.

Huntingtin suppression restores cognitive function in a mouse model of Huntingtons disease

Science Translational Medicine

Southwell, A.L. and Kordasiewicz, H.B. and Langbehn, D. and Skotte, N.H. and Parsons, M.P. and Villanueva, E.B. and Caron, N.S. and Ostergaard, M.E. and Anderson, L.M. and Xie, Y. and Cengio, L.D. and Findlay-Black, H. and Doty, C.N. and Fitsimmons, B. and Swayze, E.E. and Seth, P.P. and Raymond, L.A. and Bennett, C.F. and Hayden, M.R.

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.

JCI insight

12 / 2017

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

Neurology

12 / 2017

Reduction of mutant huntingtin in oligodendroglia rescues myelination and behavioural deficits in a model of Huntington disease

Journal of Neurochemistry

Bardile, C. F. and Garcia-Miralles, M. and Caron, N. and Teo, R. and Hayden, M. R. and Pouladi, M. A.

08 / 2017

A novel humanizedmouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

Human Molecular Genetics

Southwell, A.L. and Skotte, N.H. and Villanueva, E.B. and ?stergaard, M.E. and Gu, X. and Kordasiewicz, H.B. and Kay, C. and Cheung, D. and Xie, Y. and Waltl, S. and Cengio, L.D. and Findlay-Black, H. and Doty, C.N. and Petoukhov, E. and Iworima, D. and Slama, R. and Ooi, J. and Pouladi, M.A. and Yang, X.W. and Swayze, E.E. and Seth, P.P. and Hayden, M.R.

Pharmacogenomics strategies to optimize treatments for multiple sclerosis: Insights from clinical research

Progress in Neurobiology

Grossman, I. and Knappertz, V. and Laifenfeld, D. and Ross, C. and Zeskind, B. and Kolitz, S. and Ladkani, D. and Hayardeny, L. and Loupe, P. and Laufer, R. and Hayden, M.

Evaluation of pridopidine in the transgenic YAC128 mouse model of Huntington disease

Journal of Neurochemistry

Garcia-Miralles, M. and Yosuf, Nabm and Tan, J. Y. and Kusko, R. and Tan, L. J. and Xu, X. and Orbach, A. and Geva, M. and Hayden, M. R. and Pouladi, M. A.

Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model

Annals of the New York Academy of Sciences

Grossman, I. and Kolitz, S. and Komlosh, A. and Zeskind, B. and Weinstein, V. and Laifenfeld, D. and Gilbert, A. and Bar-Ilan, O. and Fowler, K.D. and Hasson, T. and Konya, A. and Wells-Knecht, K. and Loupe, P. and Melamed-Gal, S. and Molotsky, T. and Krispin, R. and Papir, G. and Sahly, Y. and Hayden, M.R.

Association between slc16a5 genetic variation and cisplatin-induced ototoxic effects in adult patients with testicular cancer

JAMA Oncology

Drgemller, B.I. and Monzon, J.G. and Bhavsar, A.P. and Borrie, A.E. and Brooks, B. and Wright, G.E.B. and Liu, G. and Renouf, D.J. and Kollmannsberger, C.K. and Bedard, P.L. and Aminkeng, F. and Amstutz, U. and Hildebrand, C.A. and Gunaretnam, E.P. and Critchley, C. and Chen, Z. and Brunham, L.R. and Hayden, M.R. and Ross, C.J.D. and Gelmon, K.A. and Carleton, B.C.

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

Neurobiology of Disease

Ryskamp, D. and Wu, J. and Geva, M. and Kusko, R. and Grossman, I. and Hayden, M. and Bezprozvanny, I.

Laquinimod treatment in the R6/2 mouse model

Scientific Reports

Ellrichmann, G. and Blusch, A. and Fatoba, O. and Brunner, J. and Hayardeny, L. and Hayden, M. and Sehr, D. and Winklhofer, K.F. and Saft, C. and Gold, R.

ABCA8 regulates cholesterol efflux and high-density lipoprotein cholesterol levels

Arteriosclerosis, Thrombosis, and Vascular Biology

Trigueros-Motos, L. and Van Capelleveen, J.C. and Torta, F. and Castao, D. and Zhang, L.-H. and Chai, E.C. and Kang, M. and Dimova, L.G. and Schimmel, A.W.M. and Tietjen, I. and Radomski, C. and Tan, L.J. and Thiam, C.H. and Narayanaswamy, P. and Wu, D.H. and Dorninger, F. and Yakala, G.K. and Barhdadi, A. and Angeli, V. and Dub, M.-P. and Berger, J. and Dallinga-Thie, G.M. and Tietge, U.J.F. and Wenk, M.R. and Hayden, M.R. and Kees Hovingh, G. and Singaraja, R.R.

The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America

European Journal of Human Genetics

Kay, C. and Tirado-Hurtado, I. and Cornejo-Olivas, M. and Collins, J.A. and Wright, G. and Inca-Martinez, M. and Veliz-Otani, D. and Ketelaar, M.E. and Slama, R.A. and Ross, C.J. and Mazzetti, P. and Hayden, M.R.

Neurodegeneration: Role of repeats in protein clearance

Nature

Martin, D.D.O. and Hayden, M.R.

Histone deacetylase inhibitors protect against pyruvate dehydrogenase dysfunction in huntingtons disease

Journal of Neuroscience

Naia, L. and Cunha-Oliveira, T. and Rodrigues, J. and Rosenstock, T.R. and Oliveira, A. and Ribeiro, M. and Carmo, C. and Oliveira-Sousa, S.I. and Duarte, A.I. and Hayden, M.R. and Rego, A.C.

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer

British Journal of Clinical Pharmacology

Aminkeng, F. and Ross, C.J.D. and Rassekh, S.R. and Rieder, M.J. and Bhavsar, A.P. and Sanatani, S. and Bernstein, D. and Hayden, M.R. and Amstutz, U. and Carleton, B.C.

eEF2K inhibition blocks A42 neurotoxicity by promoting an NRF2 antioxidant response

Acta Neuropathologica

Jan, A. and Jansonius, B. and Delaidelli, A. and Somasekharan, S.P. and Bhanshali, F. and Vandal, M. and Negri, G.L. and Moerman, D. and MacKenzie, I. and Calon, F. and Hayden, M.R. and Taubert, S. and Sorensen, P.H.

Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntingtons Disease Models

Molecular Neurobiology

Naia, L. and Rosenstock, T.R. and Oliveira, A.M. and Oliveira-Sousa, S.I. and Caldeira, G.L. and Carmo, C. and La?o, M.N. and Hayden, M.R. and Oliveira, C.R. and Rego, A.C.

Author response: Huntington disease reduced penetrance alleles occur at high frequency in the general population

Neurology

Hayden, M.R. and Kay, C.

Palmitoylation of caspase-6 by HIP14 regulates its activation

Cell Death and Differentiation

Skotte, N.H. and Sanders, S.S. and Singaraja, R.R. and Ehrnhoefer, D.E. and Vaid, K. and Qiu, X. and Kannan, S. and Verma, C. and Hayden, M.R.

Feeding schedule and proteolysis regulate autophagic clearance of mutant huntingtin

bioRxiv

Ehrnhoefer, D.E. and Martin, D.D.O. and Qiu, X. and Ladha, S. and Caron, N.S. and Skotte, N.H. and Nguyen, Y.T.N. and Engemann, S. and Franciosi, S. and Hayden, M.R.

Safety and Exploratory Efficacy at 36 Months in Open-HART, an Open-Label Extension Study of Pridopidine in Huntington's Disease

Journal of Huntington's Disease

McGarry, A. and Kieburtz, K. and Abler, V. and Grachev, I.D. and Gandhi, S. and Auinger, P. and Papapetropoulos, S. and Hayden, M.

Beyond Motor Effects-Pridopidine's New Therapeutic Potential

Neurotherapeutics

Geva, M. and Kusko, R. and Ryskamp, D. and Bezprozvanny, I. and Grossman, I. and Orbach, A. and Burczynski, M. and Papapetropoulos, S. and Laufer, R. and Hayden, M. R.

Epidemiology of Huntington disease

Handbook of Clinical Neurology

Kay, C. and Hayden, M.R. and Leavitt, B.R.

A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis

Genome Medicine

Ross, C.J. and Towfic, F. and Shankar, J. and Laifenfeld, D. and Thoma, M. and Davis, M. and Weiner, B. and Kusko, R. and Zeskind, B. and Knappertz, V. and Grossman, I. and Hayden, M.R.

Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.

Therapeutic drug monitoring

08 / 2016

A true mentor and pioneer in medical genetics

South African Medical Journal

Hayden, M.R.

Pharmacogenomic Strategies for the Prevention of Anthracycline-Induced Heart Failure: Validation of a Genetic Association with a Non-Synonymous Variant in RARG

Pediatric Blood & Cancer

Bhavsar, A. P. and Rassekh, S. R. and Aminkeng, F. and Li, Y. and Gunaretnam, E. and Rieder, M. J. and Bernstein, D. and Hayden, M. R. and Carleton, B. C. and Ross, C. J. D.

Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice

BMC Biology

Sanders, S.S. and Parsons, M.P. and Mui, K.K.N. and Southwell, A.L. and Franciosi, S. and Cheung, D. and Waltl, S. and Raymond, L.A. and Hayden, M.R.

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

Scientific Reports

Maillet, A. and Tan, K. and Chai, X. and Sadananda, S.N. and Mehta, A. and Ooi, J. and Hayden, M.R. and Pouladi, M.A. and Ghosh, S. and Shim, W. and Brunham, L.R.

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

Scientific Reports

Garcia-Miralles, M. and Hong, X. and Tan, L.J. and Caron, N.S. and Huang, Y. and To, X.V. and Lin, R.Y. and Franciosi, S. and Papapetropoulos, S. and Hayardeny, L. and Hayden, M.R. and Chuang, K.-H. and Pouladi, M.A.

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

Human Molecular Genetics

Southwell, A.L. and Smith-Dijak, A. and Kay, C. and Sepers, M. and Villanueva, E.B. and Parsons, M.P. and Xie, Y. and Anderson, L. and Felczak, B. and Waltl, S. and Ko, S. and Cheung, D. and Cengio, L.D. and Slama, R. and Petoukhov, E. and Raymond, L.A. and Hayden, M.R.

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

Human Molecular Genetics

Yi Teo, R.T. and Hong, X. and Yu-Taeger, L. and Huang, Y. and Tan, L.J. and Xie, Y. and To, X.V. and Guo, L. and Rajendran, R. and Novati, A. and Calaminus, C. and Riess, O. and Hayden, M.R. and Nguyen, H.P. and Chuang, K.-H. and Pouladi, M.A.

Similarities and differences in the gene expression profiles of glatopa and copaxone

Multiple Sclerosis Journal

Kolitz, S. and Laifenfeld, D. and Fowler, K. and Hasson, T. and Konya, A. and Bakshi, S. and Zeskind, B. and Grossman, I. and Hayden, M. R.

Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons

Experimental Neurology

Ehrnhoefer, D.E. and Caron, N.S. and Deng, Y. and Qiu, X. and Tsang, M. and Hayden, M.R.

Huntington disease reduced penetrance alleles occur at high frequency in the general population

Neurology

Kay, C. and Collins, J.A. and Miedzybrodzka, Z. and Madore, S.J. and Gordon, E.S. and Gerry, N. and Davidson, M. and Slama, R.A. and Hayden, M.R.

Functional effects of the antigen glatiramer acetate are complex and tightly associated with its composition

Journal of Neuroimmunology

Hasson, T. and Kolitz, S. and Towfic, F. and Laifenfeld, D. and Bakshi, S. and Beriozkin, O. and Shacham-Abramson, M. and Timan, B. and Fowler, K.D. and Birnberg, T. and Konya, A. and Komlosh, A. and Ladkani, D. and Hayden, M.R. and Zeskind, B. and Grossman, I.

Anti-SEMA4D Antibody Ameliorates Pathogenic Processes in Central Nervous System, Cognitive Impairment in the YAC128 Mouse Model of Huntington Disease, and is Well-tolerated in Patients

Neurotherapeutics

Zauderer, M. and Klimatcheva, E. and Fisher, T. and Reilly, C. and Winter, L. and Mallow, C. and Bussler, H. and Torno, S. and Howell, A. and Scrivens, M. and Balch, L. and Wang, W. and Paris, M. and Evans, E. and Southwell, A. and Hayden, M. and Leonard, J. and Smith, E.

The Aryl Hydrocarbon Receptor in the Peripheral Immune System is the Molecular Target of Laquinimod in MOG induced Experimental Autoimmune Encephalomyelitis

Multiple Sclerosis Journal

Kaye, J. and Birnberg, T. and Hingaly, T. and Raymond, E. and Piryatinsky, V. and Caballero, I. and Orbach, A. and Grossman, I. and Knappertz, V. and Hayden, M. R. and Laufer, R.

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity

British Journal of Clinical Pharmacology

Aminkeng, F. and Ross, C.J.D. and Rassekh, S.R. and Hwang, S. and Rieder, M.J. and Bhavsar, A.P. and Smith, A. and Sanatani, S. and Gelmon, K.A. and Bernstein, D. and Hayden, M.R. and Amstutz, U. and Carleton, B.C.

MITIGATE-HD: A Trial of Memantine in Huntington Disease

Neurotherapeutics

Petkau, T. and Sturrock, A. and Coleman, A. and Mackay, A. and Russell-Schulz, B. and Langbehn, D. and Hayden, M. R. and Leavitt, B. R.

Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells

Journal of Neurochemistry

Dobson, L. and Trger, U. and Farmer, R. and Hayardeny, L. and Loupe, P. and Hayden, M.R. and Tabrizi, S.J.

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor

Proceedings of the National Academy of Sciences of the United States of America

Kaye, J. and Piryatinsky, V. and Birnberg, T. and Hingaly, T. and Raymond, E. and Kashi, R. and Amit-Romach, E. and Caballero, I.S. and Towfic, F. and Ator, M.A. and Rubinstein, E. and Laifenfeld, D. and Orbach, A. and Shinar, D. and Marantz, Y. and Grossman, I. and Knappertz, V. and Hayden, M.R. and Laufer, R.

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease

Experimental Neurology

Garcia-Miralles, M. and Ooi, J. and Ferrari Bardile, C. and Tan, L.J. and George, M. and Drum, C.L. and Lin, R.Y. and Hayden, M.R. and Pouladi, M.A.

Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: Implications for clinical implementation of pharmacogenomics

Pharmacogenetics and Genomics

Chan, S.L. and Samaranayake, N. and Ross, C.J.D. and Toh, M.T. and Carleton, B. and Hayden, M.R. and Teo, Y.Y. and Dissanayake, V.H.W. and Brunham, L.R.

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease

Molecular Therapy - Nucleic Acids

Miniarikova, J. and Zanella, I. and Huseinovic, A. and van der Zon, T. and Hanemaaijer, E. and Martier, R. and Koornneef, A. and Southwell, A.L. and Hayden, M.R. and van Deventer, S.J. and Petry, H. and Konstantinova, P.

Similarities and differences in the gene expression profiles of copaxone and polimunol

Multiple Sclerosis Journal

Laifenfeld, D. and Hasson, T. and Kolitz, S. E. and Fowler, K. D. and Konya, A. and Bakshi, S. and Zeskind, B. and Grossman, I. and Hayden, M. R.

Rationale and Design for LEGATO-HD Study: A Multinational, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Laquinimod (0.5, 1.0, and 1.5 mg/day) as Treatment in Patients with Huntington Disease

Neurotherapeutics

Reilmann, R. and Tabrizi, S. and Leavitt, B. and Stout, J. C. and Piccini, P. and Anderson, K. E. and Feigin, A. and Hayden, M. and Grozinski-Wolff, M. and Eyal, E. and Papapetropoulos, S.

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin

Neuropeptides

Naia, L. and Ribeiro, M. and Rodrigues, J. and Duarte, A.I. and Lopes, C. and Rosenstock, T.R. and Hayden, M.R. and Rego, A.C.

Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin

Neuroscience

Connolly, C. and Magnusson-Lind, A. and Lu, G. and Wagner, P.K. and Southwell, A.L. and Hayden, M.R. and Bjrkqvist, M. and Leavitt, B.R.

Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: A pharmacogenetic study

Brain

Masellis, M. and Collinson, S. and Freeman, N. and Tampakeras, M. and Levy, J. and Tchelet, A. and Eyal, E. and Berkovich, E. and Eliaz, R.E. and Abler, V. and Grossman, I. and Fitzer-Attas, C. and Tiwari, A. and Hayden, M.R. and Kennedy, J.L. and Lang, A.E. and Knight, J.

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice

Diabetologia

Wijesekara, N. and Kaur, A. and Westwell-Roper, C. and Nackiewicz, D. and Soukhatcheva, G. and Hayden, M.R. and Verchere, C.B.

A novel microdeletion affecting the CETP gene raises HDL-associated cholesterol levels

Clinical Genetics

Hitchcock, E. and Patankar, J.V. and Tyson, C. and Hrynchak, M. and Hayden, M.R. and Gibson, W.T.

Pridopidine activates neuroprotective pathways impaired in Huntington Disease

Human Molecular Genetics

Geva, M. and Kusko, R. and Soares, H. and Fowler, K.D. and Birnberg, T. and Barash, S. and Merenlender-Wagner, A. and Fine, T. and Lysaght, A. and Weiner, B. and Cha, Y. and Kolitz, S. and Towfic, F. and Orbach, A. and Laufer, R. and Zeskind, B. and Grossman, I. and Hayden, M.R.

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD

Human Molecular Genetics

Riechers, S.-P. and Butland, S. and Deng, Y. and Skotte, N. and Ehrnhoefer, D.E. and Russ, J. and Laine, J. and Laroche, M. and Pouladi, M.A. and Wanker, E.E. and Hayden, M.R. and Graham, R.K.

Association of a multi-SNP signature with response to copaxone (Glatiramer Acetate) in a subset of patients and in multiple RRMS patient cohorts

Multiple Sclerosis Journal

Ross, C. and Towfic, F. and Shankar, J. and Laifenfeld, D. and Davies, M. and Thoma, M. and Zeskind, B. and Knappertz, V. and Grossman, I. and Hayden, M. R.

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers

Movement Disorders

Sturrock, A. and Laule, C. and Wyper, K. and Milner, R.A. and Decolongon, J. and Santos, R.D. and Coleman, A.J. and Carter, K. and Creighton, S. and Bechtel, N. and Bohlen, S. and Reilmann, R. and Johnson, H.J. and Hayden, M.R. and Tabrizi, S.J. and Mackay, A.L. and Leavitt, B.R.

Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1

Diabetes

Kaur, A. and Patankar, J.V. and De Haan, W. and Ruddle, P. and Wijesekara, N. and Groen, A.K. and Verchere, C.B. and Singaraja, R.R. and Hayden, M.R.

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy

Therapeutic Drug Monitoring

Shaw, K. and Amstutz, U. and Kim, R.B. and Lesko, L.J. and Turgeon, J. and Michaud, V. and Hwang, S. and Ito, S. and Ross, C. and Carleton, B.C. and Hayden, M.R. and Hosking, M. and Virani, S. and MacLeod, S. and Rassekh, R. and Smith, A. and Brunham, L. and Shear, N.H. and Koren, G. and Liu, G. and Rieder, M.J. and Kim, R. and Maher, M. and Flockhart, D. and Lesko, L. and Rhoades, J.

Autophagy in Huntington disease and huntingtin in autophagy

Trends in Neurosciences

Martin, D.D.O. and Ladha, S. and Ehrnhoefer, D.E. and Hayden, M.R.

A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer

Nature Genetics

Aminkeng, F. and Bhavsar, A.P. and Visscher, H. and Rassekh, S.R. and Li, Y. and Lee, J.W. and Brunham, L.R. and Caron, H.N. and Van Dalen, E.C. and Kremer, L.C. and Van Der Pal, H.J. and Amstutz, U. and Rieder, M.J. and Bernstein, D. and Carleton, B.C. and Hayden, M.R. and Ross, C.J.D.

Loss-of-function mutations in ABCA1 and enhanced -cell secretory capacity in young adults. diabetes 2015;64:193-199

Diabetes

Patankar, J.V. and Brunham, L.R. and Hayden, M.R.

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease

Neurobiology of Disease

Southwell, A.L. and Franciosi, S. and Villanueva, E.B. and Xie, Y. and Winter, L.A. and Veeraraghavan, J. and Jonason, A. and Felczak, B. and Zhang, W. and Kovalik, V. and Waltl, S. and Hall, G. and Pouladi, M.A. and Smith, E.S. and Bowers, W.J. and Zauderer, M. and Hayden, M.R.

Aberrant palmitoylation in Huntington disease

Biochemical Society Transactions

Sanders, S.S. and Hayden, M.R.

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits

Human Molecular Genetics

Aharony, I. and Ehrnhoefer, D.E. and Shruster, A. and Qiu, X. and Franciosi, S. and Hayden, M.R. and Offen, D.

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Neurobiology of Disease

Wong, B.K.Y. and Ehrnhoefer, D.E. and Graham, R.K. and Martin, D.D.O. and Ladha, S. and Uribe, V. and Stanek, L.M. and Franciosi, S. and Qiu, X. and Deng, Y. and Kovalik, V. and Zhang, W. and Pouladi, M.A. and Shihabuddin, L.S. and Hayden, M.R.

Gene expression studies of a human monocyte cell line identify dissimilarities between differently manufactured glatiramoids

Scientific Reports

Kolitz, S. and Hasson, T. and Towfic, F. and Funt, J.M. and Bakshi, S. and Fowler, K.D. and Laifenfeld, D. and Grinspan, A. and Artyomov, M.N. and Birnberg, T. and Schwartz, R. and Komlosh, A. and Hayardeny, L. and Ladkani, D. and Hayden, M.R. and Zeskind, B. and Grossman, I.

Direct intracerebral delivery of a miR-33 antisense oligonucelotide into mouse brain increases brain ABCA1 expression

Neuroscience Letters

Jan, A. and Karasinska, J.M. and Kang, M.H. and de Haan, W. and Ruddle, P. and Kaur, A. and Connolly, C. and Leavitt, B.R. and Sorensen, P.H. and Hayden, M.R.

Human genetics of HDL: Insight into particle metabolism and function

Progress in Lipid Research

Brunham, L.R. and Hayden, M.R.

Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides

ACS Chemical Biology

?stergaard, M.E. and Thomas, G. and Koller, E. and Southwell, A.L. and Hayden, M.R. and Seth, P.P.

A new mutation for Huntington disease following maternal transmission of an intermediate allele

European Journal of Medical Genetics

Semaka, A. and Kay, C. and Belfroid, R.D.M. and Bijlsma, E.K. and Losekoot, M. and van Langen, I.M. and van Maarle, M.C. and Oosterloo, M. and Hayden, M.R. and van Belzen, M.J.

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

Scientific Reports

Southwell, A.L. and Smith, S.E.P. and Davis, T.R. and Caron, N.S. and Villanueva, E.B. and Xie, Y. and Collins, J.A. and Li Ye, M. and Sturrock, A. and Leavitt, B.R. and Schrum, A.G. and Hayden, M.R.

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

Genome Research

Stroedicke, M. and Bounab, Y. and Strempel, N. and Klockmeier, K. and Yigit, S. and Friedrich, R.P. and Chaurasia, G. and Li, S. and Hesse, F. and Riechers, S.-P. and Russ, J. and Nicoletti, C. and Boeddrich, A. and Wiglenda, T. and Haenig, C. and Schnoegl, S. and Fournier, D. and Graham, R.K. and Hayden, M.R. and Sigrist, S. and Bates, G.P. and Priller, J. and Andrade-Navarro, M.A. and Futschik, M.E. and Wanker, E.E.

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children

Pharmacogenomics

Visscher, H. and Rassekh, S.R. and Sandor, G.S. and Caron, H.N. and Van Dalen, E.C. and Kremer, L.C. and Van Der Pal, H.J. and Rogers, P.C. and Rieder, M.J. and Carleton, B.C. and Hayden, M.R. and Ross, C.J.

Corrigendum to "Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression'' [Neuroscience Letters 598 (2015) 66-72]

Neuroscience Letters

Jan, A. and Karasinska, J.M. and Kang, M.H. and Haan, W.D. and Ruddle, P. and Kaur, A. and Connolly, C. and Leavitt, B.R. and Sorensen, P.H. and Hayden, M.R.

A SNP in the HTT promoter alters NF-B binding and is a bidirectional genetic modifier of Huntington disease

Nature Neuroscience

Becanovic, K. and N?rrem?lle, A. and Neal, S.J. and Kay, C. and Collins, J.A. and Arenillas, D. and Lilja, T. and Gaudenzi, G. and Manoharan, S. and Doty, C.N. and Beck, J. and Lahiri, N. and Portales-Casamar, E. and Warby, S.C. and Connolly, C. and De Souza, R.A.G. and Tabrizi, S.J. and Hermanson, O. and Langbehn, D.R. and Hayden, M.R. and Wasserman, W.W. and Leavitt, B.R.

Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration

Biochemical Society Transactions

Martin, D.D.O. and Hayden, M.R.

Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease

Molecular Neurobiology

Ooi, J. and Hayden, M.R. and Pouladi, M.A.

Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development

Developmental Biology

Sanders, S.S. and Hou, J. and Sutton, L.M. and Garside, V.C. and Mui, K.K.N. and Singaraja, R.R. and Hayden, M.R. and Hoodless, P.A.

Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in huntington disease patients of european ancestry

Molecular Therapy

Kay, C. and Collins, J.A. and Skotte, N.H. and Southwell, A.L. and Warby, S.C. and Caron, N.S. and Doty, C.N. and Nguyen, B. and Griguoli, A. and Ross, C.J. and Squitieri, F. and Hayden, M.R.

Targeted next-generation sequencing to diagnose disorders of HDL cholesterol

Journal of Lipid Research

Sadananda, S.N. and Foo, J.N. and Toh, M.T. and Cermakova, L. and Trigueros-Motos, L. and Chan, T. and Liany, H. and Collins, J.A. and Gerami, S. and Singaraja, R.R. and Hayden, M.R. and Francis, G.A. and Frohlich, J. and Khor, C.C. and Brunham, L.R.

Huntington disease

Nature Reviews Disease Primers

Bates, G.P. and Dorsey, R. and Gusella, J.F. and Hayden, M.R. and Kay, C. and Leavitt, B.R. and Nance, M. and Ross, C.A. and Scahill, R.I. and Wetzel, R. and Wild, E.J. and Tabrizi, S.J.

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers

PLoS Computational Biology

Sanders, S.S. and Martin, D.D.O. and Butland, S.L. and Lavalle-Adam, M. and Calzolari, D. and Kay, C. and Yates, J.R. and Hayden, M.R.

Clinical, biochemical, and molecular characterization of novel mutations in ABCA1 in families with tangier disease

JIMD Reports

Brunham, L.R. and Kang, M.H. and Van Karnebeek, C. and Sadananda, S.N. and Collins, J.A. and Zhang, L.-H. and Sayson, B. and Miao, F. and Stockler, S. and Frohlich, J. and Cassiman, D. and Rabkin, S.W. and Hayden, M.R.

Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: Providing a therapeutic option for all Huntington disease patients

PLoS ONE

Skotte, N.H. and Southwell, A.L. and ?stergaard, M.E. and Carroll, J.B. and Warby, S.C. and Doty, C.N. and Petoukhov, E. and Vaid, K. and Kordasiewicz, H. and Watt, A.T. and Freier, S.M. and Hung, G. and Seth, P.P. and Bennett, C.F. and Swayze, E.E. and Hayden, M.R.

Pharmacogenomic diversity in Singaporean populations and Europeans

Pharmacogenomics Journal

Brunham, L.R. and Chan, S.L. and Li, R. and Aminkeng, F. and Liu, X. and Saw, W.Y. and Ong, R.T.H. and Pillai, E.N. and Carleton, B.C. and Toh, D. and Tan, S.H. and Koo, S.H. and Lee, E.J.D. and Chia, K.S. and Ross, C.J.D. and Hayden, M.R. and Sung, C. and Teo, Y.Y.

Laquinimod reduces neuronal caspase-6 activation and axonal degeneration in vitro

Movement Disorders

Ehrnhoefer, D. E. and Tsang, M. Y. and Qiu, X. and Hayden, M. R.

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans

Journal of Lipid Research

Singaraja, R.R. and Tietjen, I. and Hovingh, G.K. and Franchini, P.L. and Radomski, C. and Wong, K. and VanHeek, M. and Stylianou, I.M. and Lin, L. and Wang, L. and Mitnaul, L. and Hubbard, B. and Winther, M. and Mattice, M. and Legendre, A. and Sherrington, R. and Kastelein, J.J. and Akinsanya, K. and Plump, A. and Hayden, M.R.

High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice

Journal of Lipid Research

Rinninger, F. and Heine, M. and Singaraja, R. and Hayden, M. and Brundert, M. and Ramakrishnan, R. and Heeren, J.

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

Human Molecular Genetics

Mattis, V.B. and Tom, C. and Akimov, S. and Saeedian, J. and ?stergaard, M.E. and Southwell, A.L. and Doty, C.N. and Ornelas, L. and Sahabian, A. and Lenaeus, L. and Mandefro, B. and Sareen, D. and Arjomand, J. and Hayden, M.R. and Ross, C.A. and Svendsen, C.N.

Evidence-based genetic counselling implications for Huntington disease intermediate allele predictive test results

Clinical Genetics

Semaka, A. and Hayden, M.R.

CODEINE-RELATED DEATHS IN ONTARIO, CANADA: THE ROLE OF PHARMACOGENETICS AND DRUG INTERACTIONS

Clinical Pharmacology & Therapeutics

Lam, J. and Woodall, K. and Solbeck, P. and Ross, C. J. and Carleton, B. C. and Hayden, M. R. and Koren, G. and Madadi, P.

Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin

Human Molecular Genetics

Martin, D.D.O. and Heit, R.J. and Yap, M.C. and Davidson, M.W. and Hayden, M.R. and Berthiaume, L.G.

Comparing the biological impact of glatiramer acetate with the biological impact of a generic

PLoS ONE

Towfic, F. and Funt, J.M. and Fowler, K.D. and Bakshi, S. and Blaugrund, E. and Artyomov, M.N. and Hayden, M.R. and Ladkani, D. and Schwartz, R. and Zeskind, B.

Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of huntington disease

PLoS ONE

Kolodziejczyk, K. and Parsons, M.P. and Southwell, A.L. and Hayden, M.R. and Raymond, L.A.

Personalized gene silencing therapeutics for Huntington disease

Clinical Genetics

Kay, C. and Skotte, N.H. and Southwell, A.L. and Hayden, M.R.

Genetic markers of cisplatin-induced hearing loss in children

Clinical Pharmacology and Therapeutics

Carleton, B.C. and Ross, C.J. and Pussegoda, K. and Bhavsar, A.P. and Visscher, H. and Lee, J.W. and Brooks, B. and Rassekh, S.R. and Dub, M.-P.P. and Hayden, M.R.

VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children

Pediatric Blood and Cancer

Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S.R. and Hosking, M. and Neville, K. and Leeder, J.S. and Hayden, M.R. and Ross, C.J. and Carleton, B.C.

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

Human Molecular Genetics

Ehrnhoefer, D.E. and Skotte, N.H. and Ladha, S. and Nguyen, Y.T.N. and Qiu, X. and Deng, Y. and Huynh, K.T. and Engemann, S. and Nielsen, S.M. and Becanovic, K. and Leavitt, B.R. and Hasholt, L. and Hayden, M.R.

Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritis

Journal of Neuroimmunology

Pitarokoili, K. and Ambrosius, B. and Schrewe, L. and Hayardeny, L. and Hayden, M. and Gold, R.

Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent

Pharmacogenomics Journal

Aminkeng, F. and Ross, C.J.D. and Rassekh, S.R. and Brunham, L.R. and Sistonen, J. and Dube, M.-P. and Ibrahim, M. and Nyambo, T.B. and Omar, S.A. and Froment, A. and Bodo, J.-M. and Tishkoff, S. and Carleton, B.C. and Hayden, M.R.

Hepatic ABCA1 expression improves -cell function and glucose tolerance

Diabetes

De Haan, W. and Karasinska, J.M. and Ruddle, P. and Hayden, M.R.

ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity

Journal of Lipid Research

De Haan, W. and Bhattacharjee, A. and Ruddle, P. and Kang, M.H. and Hayden, M.R.

Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families

Clinical Genetics

Bochem, A.E. and van Capelleveen, J.C. and Dallinga-Thie, G.M. and Schimmel, A.W.M. and Motazacker, M.M. and Tietjen, I. and Singaraja, R.R. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.G. and Hovingh, G.K.

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides

Molecular Therapy

Southwell, A.L. and Skotte, N.H. and Kordasiewicz, H.B. and ?stergaard, M.E. and Watt, A.T. and Carroll, J.B. and Doty, C.N. and Villanueva, E.B. and Petoukhov, E. and Vaid, K. and Xie, Y. and Freier, S.M. and Swayze, E.E. and Seth, P.P. and Bennett, C.F. and Hayden, M.R.

A novel inhibitor of Caspase-6 provides protection against mutant huntingtin toxicity

Journal of Molecular Neuroscience

Aharony, I. and Ehrnhoefer, D. and Shruster, A. and Franciosi, S. and Hayden, M. R. and Offen, D.

Use of genetic technologies to compare medicines

Clinical Genetics

Kolitz, S.E. and Towfic, F. and Grossman, I. and Hayden, M.R. and Zeskind, B.

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: Implications for a role in the pathogenesis of Huntington's disease

Human Molecular Genetics

Butland, S.L. and Sanders, S.S. and Schmidt, M.E. and Riechers, S.-P. and Lin, D.T.S. and Martin, D.D.O. and Vaid, K. and Graham, R.K. and Singaraja, R.R. and Wanker, E.E. and Conibear, E. and Hayden, M.R.

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity

Clinical Pharmacology and Therapeutics

Carleton, B.C. and Ross, C.J. and Bhavsar, A.P. and Amstutz, U. and Pussegoda, K. and Visscher, H. and Lee, J.W. and Brooks, B. and Rassekh, S.R. and Dub, M.-P. and Hayden, M.R.

Examining conditional caspase-6 deficiency as a therapeutic in Huntington's disease

Movement Disorders

Ladha, S. and Wong, B. K. Y. and Hayden, M. R.

Response to "Evaluation of Pharmacogenetic Markers to Predict the Risk of Cisplatin-Induced Ototoxicity"

Clinical Pharmacology and Therapeutics

Carleton, B.C. and Ross, C.J. and Bhavsar, A.P. and Lee, J.W. and Visscher, H. and Rassekh, S.R. and Hayden, M.R.

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

Proceedings of the National Academy of Sciences of the United States of America

Rotblat, B. and Southwell, A.L. and Ehrnhoefer, D.E. and Skotte, N.H. and Metzler, M. and Franciosi, S. and Leprivier, G. and Somasekharan, S.P. and Barokas, A. and Deng, Y. and Tang, T. and Mathers, J. and Cetinbas, N. and Daugaard, M. and Kwok, B. and Li, L. and Carnie, C.J. and Fink, D. and Nitsch, R. and Galpin, J.D. and Ahern, C.A. and Melino, G. and Penninger, J.M. and Hayden, M.R. and Sorensen, P.H.

Elevated cytokine release in microglia from Huntington's disease mice is reversed by laquinimod

Movement Disorders

Leavitt, B. R. and Connolly, C. and Wagner, P. K. and Hayardeny, L. and Hayden, M. R.

Bidirectional control of Postsynaptic Density-95 (PSD-95) clustering by Huntingtin

Journal of Biological Chemistry

Parsons, M.P. and Kang, R. and Buren, C. and Dau, A. and Southwell, A.L. and Doty, C.N. and Sanders, S.S. and Hayden, M.R. and Raymond, L.A.

The emerging era of pharmacogenomics: Current successes, future potential, and challenges

Clinical Genetics

Lee, J.W. and Aminkeng, F. and Bhavsar, A.P. and Shaw, K. and Carleton, B.C. and Hayden, M.R. and Ross, C.J.D.

Public perceptions of pharmacogenetics

Pediatrics

Zhang, S.C. and Bruce, C. and Hayden, M. and Rieder, M.J.

Multisource ascertainment of Huntington disease in Canada: Prevalence and population at risk

Movement Disorders

Fisher, E.R. and Hayden, M.R.

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice

Molecular Neurobiology

Lopes, C. and Ribeiro, M. and Duarte, A.I. and Humbert, S. and Saudou, F. and Pereira De Almeida, L. and Hayden, M. and Rego, A.C.

Identification of binding sites in huntingtin for the huntingtin interacting proteins HIP14 and HIP14L

PLoS ONE

Sanders, S.S. and Mui, K.K.N. and Sutton, L.M. and Hayden, M.R.

Development of a broad-based ADME panel for use in pharmacogenomic studies

Pharmacogenomics

Brown, A.M.K. and Renaud, Y. and Ross, C. and Hansen, M. and Mongrain, I. and Valois, D. and Carleton, B.C. and Hayden, M.R. and Dub, M.-P. and Tardif, J.-C. and Phillips, M.S.

Codeine-related deaths: The role of pharmacogenetics and drug interactions

Forensic Science International

Lam, J. and Woodall, K.L. and Solbeck, P. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G. and Madadi, P.

Genetic Variation Does Not Influence Renal Function Following Pediatric Kidney Transplantation Receiving Tacrolimus

Therapeutic Drug Monitoring

Gijsen, Vmgj and Hesselink, D. A. and Ross, C. and Dube, M. P. and van Schaik, R. H. N. and Van Gelder, T. and Cransberg, K. and t Jong, G. W. and Feroz-Zada, Y. and Nasserinejad, K. and van Rosmalen, J. and Hebert, D. and Grant, D. and Verjee, Z. and Carlton, B. and Hayden, M. R. and Tibboel, D. and de Wildt, S. N. and Koren, G.

Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children

Clinical Pharmacology and Therapeutics

Pussegoda, K. and Ross, C.J. and Visscher, H. and Yazdanpanah, M. and Brooks, B. and Rassekh, S.R. and Zada, Y.F. and Dub, M.-P. and Carleton, B.C. and Hayden, M.R.

Recommendations for the predictive genetic test in Huntington's disease

Clinical Genetics

Macleod, R. and Tibben, A. and Frontali, M. and Evers-Kiebooms, G. and Jones, A. and Martinez-Descales, A. and Roos, R. and Bijlsma, E. and Blinkenberg, E. and Bombard, Y. and Borry, P. and Craufurd, D. and Davis, M. and De Die-Smulders, C. and Downing, C. and Drr, A. and Garcia Barcina, M. and Glew, R. and Heiberg, A. and Heydon, F. and Hoffman-Zacharsk, D. and Hsterey Ugander, U. and Jos Trujillo Tiebas, M. and Krysa, W. and Liebaers, I. and Lohkamp, C. and Mandich, P. and Mariotti, C. and De Schepper, B. and Di Maria, E. and Nemeth, A. and Quarrell, O. and Riba, P. and Semaka, A. and Seneca, S. and Sequeiros, J. and Squitieri, F. and Sulek, A. and Van Der Meer, L. and Verellen-Dumoulin, C. and De Wert, G. and Delatycki, M. and Guttman, M. and Hayden, M. and Nance, M. and Richards, F. and Vetter, L.

Pharmacogenomics of vincristine-induced neurotoxicity in pediatric cancer patients

Faseb Journal

Amstutz, U. and Loo, T. T. and Gylling, H. M. and Rassekh, R. and Hukin, J. and Zada, Y. F. and Dube, M. P. and Brown, A. M. and Phillips, M. S. and Hayden, M. R. and Ross, C. J. and Carleton, B. C.

Pharmacogenomic investigation of adverse drug reactions (ADRS): The ADR prioritization tool, APT

Journal of Population Therapeutics and Clinical Pharmacology

Shaw, K. and Amstutz, U. and Castro-Pastrana, L. and Loo, T.T. and Ross, C.J. and Ito, S. and Rieder, M.J. and Maher, M. and MacLeod, S. and Koren, G. and Hayden, M.R. and Carleton, B.C.

Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease

Human Molecular Genetics

Sutton, L.M. and Sanders, S.S. and Butland, S.L. and Singaraja, R.R. and Franciosi, S. and Southwell, A.L. and Doty, C.N. and Schmidt, M.E. and Mui, K.K. and Kovalik, V. and Young, F.B. and Zhang, W. and Hayden, M.R.

Cancer pharmacogenomics in children: Research initiatives and progress to date

Pediatric Drugs

Rassekh, S.R. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R.

Antisense oligonucleotide-mediated correction of transcriptional dysregulation is correlated with behavioral benefits in the YAC128 mouse model of huntingtons disease

Journal of Huntington's Disease

Stanek, L.M. and Yang, W. and Angus, S. and Sardi, P.S. and Hayden, M.R. and Hung, G.H. and Frank Bennett, C. and Cheng, S.H. and Shihabuddin, L.S.

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy

Journal of Population Therapeutics and Clinical Pharmacology

Madadi, P. and Amstutz, U. and Rieder, M. and Ito, S. and Fung, V. and Hwang, S. and Turgeon, J. and Michaud, V. and Koren, G. and Carleton, B.C. and Hayden, M.R. and Ross, C.J. and MacLeod, S. and Rassekh, R. and Lauder, G. and Smith, A. and Brunham, L. and Shear, N.H. and Liu, G. and Kim, R. and Maher, M. and Flockhart, D.

Causes of Variability in Deterioration of Renal Function Among Pediatric Liver Transplant Recipients Receiving Tacrolimus

Therapeutic Drug Monitoring

Gijsen, Vmgj and Hesselink, D. A. and t Jong, G. W. and van Schaik, R. H. N. and Ng, V. and Grant, D. and FerozZada, Y. and Nasserinejad, K. and van Rosmalen, J. and Verjee, Z. and Ross, C. and Carleton, B. and Hayden, M. R. and Tibboel, D. and Dube, M. P. and Koren, G. and de Wildt, S. N.

CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease

Journal of Medical Genetics

Semaka, A. and Kay, C. and Doty, C. and Collins, J.A. and Bijlsma, E.K. and Richards, F. and Goldberg, Y.P. and Hayden, M.R.

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

Nature Medicine

Marco, S. and Giralt, A. and Petrovic, M.M. and Pouladi, M.A. and Martnez-Turrillas, R. and Martnez-Hernndez, J. and Kaltenbach, L.S. and Torres-Peraza, J. and Graham, R.K. and Watanabe, M. and Lujn, R. and Nakanishi, N. and Lipton, S.A. and Lo, D.C. and Hayden, M.R. and Alberch, J. and Wesseling, J.F. and Prez-Otao, I.

Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers

Therapeutic Drug Monitoring

Lam, J. and Kelly, L. and Matok, I. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Madadi, P. and Koren, G.

Mutations In ABCA8 Result In HDL Deficiency And Cholesterol Efflux Defects

Circulation Research

Singaraja, R. and van Capelleveen, J. and Hovingh, K. and Zhang, L. H. and Dallinga-Thie, G. and Tietjen, I. and Wong, K. and Kastelein, J. J. and Hayden, M. R.

Memory and synaptic deficits in Hip14/DHHC17 knockout mice

Proceedings of the National Academy of Sciences of the United States of America

Milnerwood, A.J. and Parsons, M.P. and Young, F.B. and Singaraja, R.R. and Franciosi, S. and Volta, M. and Bergeron, S. and Hayden, M.R. and Raymond, L.A.

Developing a comprehensive, effective patient-friendly website to enhance decision making in predictive testing for Huntington disease

Genetics in Medicine

Virani, A.K.H. and Creighton, S.M. and Hayden, M.R.

An Education Based Intervention Study for Reducing CNS Depression among Neonates Exposed to Codeine through Breast Milk

Birth Defects Research Part a-Clinical and Molecular Teratology

Chaudhry, S. and Kelly, L. E. and Rieder, M. and T'Jong, G. and Morretti, M. and Lausman, A. and Ross, C. and Berger, H. and Carleton, B. and Hayden, M. R. and Madadi, P. and Koren, G.

ABCA1 influences neuroinflammation and neuronal death

Neurobiology of Disease

Karasinska, J.M. and de Haan, W. and Franciosi, S. and Ruddle, P. and Fan, J. and Kruit, J.K. and Stukas, S. and Ltjohann, D. and Gutmann, D.H. and Wellington, C.L. and Hayden, M.R.

A systematic review and meta-analysis of clinical variables used in Huntington disease research

Movement Disorders

Franciosi, S. and Shim, Y. and Lau, M. and Hayden, M.R. and Leavitt, B.R.

The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-chaperone Activity of SGT1 to Subvert Immunity

PLoS Pathogens

Bhavsar, A.P. and Brown, N.F. and Stoepel, J. and Wiermer, M. and Martin, D.D.O. and Hsu, K.J. and Imami, K. and Ross, C.J. and Hayden, M.R. and Foster, L.J. and Li, X. and Hieter, P. and Finlay, B.B.

From mutation identification to therapy: Discovery and origins of the first approved gene therapy in the western world

Human Gene Therapy

Kastelein, J.J.P. and Ross, C.J.D. and Hayden, M.R.

The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans

Circulation: Cardiovascular Genetics

Singaraja, R.R. and Sivapalaratnam, S. and Hovingh, K. and Dub, M.-P. and Castro-Perez, J. and Collins, H.L. and Adelman, S.J. and Riwanto, M. and Manz, J. and Hubbard, B. and Tietjen, I. and Wong, K. and Mitnaul, L.J. and Van Heek, M. and Lin, L. and Roddy, T.A. and McEwen, J. and Dallinge-Thie, G. and Van Vark-Van Der Zee, L. and Verwoert, G. and Winther, M. and Van Duijn, C. and Hofman, A. and Trip, M.D. and Marais, A.D. and Asztalos, B. and Landmesser, U. and Sijbrands, E. and Kastelein, J.J. and Hayden, M.R.

Pharmacogenetics of warfarin safety and effectiveness in children

Faseb Journal

Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S. R. and Dube, M. P. and Hayden, M. R. and Ross, C. J. and Carleton, B. C.

An investigation of morphine-to-codeine metabolic ratios in postmortem blood, drug interactions, and cytochrome P450 2D6 (CYP2D6) genotype

Faseb Journal

Lam, J. and Woodall, K. and Solbeck, P. and Ross, C. J. D. and Carleton, B. and Hayden, M. R. and Koren, G. and Madadi, P.

A fully humanized transgenic mouse model of Huntington disease

Human Molecular Genetics

Southwell, A.L. and Warby, S.C. and Carroll, J.B. and Doty, C.N. and Skotte, N.H. and Zhang, W. and Villanueva, E.B. and Kovalik, V. and Xie, Y. and Pouladi, M.A. and Collins, J.A. and Yang, X.W. and Franciosi, S. and Hayden, M.R.

Tracking brain palmitoylation change: Predominance of glial change in a mouse model of Huntington's disease

Chemistry and Biology

Wan, J. and Savas, J.N. and Roth, A.F. and Sanders, S.S. and Singaraja, R.R. and Hayden, M.R. and Yates III, J.R. and Davis, N.G.

Special new feature in Clinical Genetics

Clinical Genetics

Hayden, M.R.

Sirtuin modulators alter mitochondrial function in in vitro and in vivo Huntington's disease models

European Journal of Clinical Investigation

Naia, L. and Rosenstock, T. R. and Oliveira-Sousa, S. I. and Caldeira, G. L. and Laco, M. N. and Hayden, M. R. and Rego, A. C.

Predicting Anthracycline-induced Cardiotoxicity in Children - Genome-Wide Association Study

Faseb Journal

Aminkeng, F. and Ross, C. J. D. and Rassekh, R. S. and Brunham, L. R. and Weissman, C. and Dube, M. P. and Visscher, H. and Rieder, M. J. and Carleton, B. C. and Hayden, M. R.

Life-threatening adverse events following therapeutic opioid administration in adults: Is pharmacogenetic analysis useful?

Pain Research and Management

Madadi, P. and Sistonen, J. and Silverman, G. and Gladdy, R. and Ross, C.J. and Carleton, B.C. and Carvalho, J.C. and Hayden, M.R. and Koren, G.

Investigating Genetic and Clinical Sources of Variability in Predicting Deterioration of Renal Function Among Pediatric Heart Transplant Recipients Receiving Tacrolimus

Therapeutic Drug Monitoring

Gijsen, Vmgj and Dube, M. P. and Hesselink, D. A. and Ross, C. and Mital, S. and t Jong, G. W. and van Schaik, R. H. N. and Dalinghaus, M. and Grant, D. and Zada, Y. F. and Nasserinejad, K. and van Rosmalen, J. and Verjee, Z. and Carleton, B. and Hayden, M. R. and Tibboel, D. and Koren, G. and de Wildt, S. N.

High frequency of intermediate alleles on huntington disease-associated haplotypes in British Columbia's general population

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Semaka, A. and Kay, C. and Doty, C.N. and Collins, J.A. and Tam, N. and Hayden, M.R.

Erratum: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy (Nature Genetics (2009) 41 (1345-1349))

Nature Genetics

Ross, C.J.D. and Katzov-Eckert, H. and Dub, M.-P. and Brooks, B. and Rassekh, S.R. and Barhdadi, A. and Feroz-Zada, Y. and Visscher, H. and Brown, A.M.K. and Rieder, M.J. and Rogers, P.C. and Phillips, M.S. and Carleton, B.C. and Hayden, M.R.

Choosing an animal model for the study of Huntington's disease

Nature Reviews Neuroscience

Pouladi, M.A. and Morton, A.J. and Hayden, M.R.

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset

Neurogenetics

Ramos, E.M. and Latourelle, J.C. and Gillis, T. and Mysore, J.S. and Squitieri, F. and Di Pardo, A. and Di Donato, S. and Gellera, C. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Gusella, J.F. and Lee, J.-M. and Alonso, I. and Sequeiros, J. and Myers, R.H. and MacDonald, M.E.

A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk

PLoS ONE

Kelly, L.E. and Chaudhry, S.A. and Rieder, M.J. and 't Jong, G. and Moretti, M.E. and Lausman, A. and Ross, C. and Berger, H. and Carleton, B. and Hayden, M.R. and Madadi, P. and Koren, G.

"Grasping the grey": Patient understanding and interpretation of an intermediate allele predictive test result for huntington disease

Journal of Genetic Counseling

Semaka, A. and Balneaves, L.G. and Hayden, M.R.

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

Nucleic Acids Research

?stergaard, M.E. and Southwell, A.L. and Kordasiewicz, H. and Watt, A.T. and Skotte, N.H. and Doty, C.N. and Vaid, K. and Villanueva, E.B. and Swayze, E.E. and Bennett, C.F. and Hayden, M.R. and Seth, P.P.

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6

Cell Death and Differentiation

Van Raam, B.J. and Ehrnhoefer, D.E. and Hayden, M.R. and Salvesen, G.S.

Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes

European Journal of Human Genetics

Baine, F.K. and Kay, C. and Ketelaar, M.E. and Collins, J.A. and Semaka, A. and Doty, C.N. and Krause, A. and Jacquie Greenberg, L. and Hayden, M.R.

HLA-A*31:01 and HLA-B*15:02 as genetic markers for carbamazepine hypersensitivity in children

Clinical Pharmacology and Therapeutics

Amstutz, U. and Ross, C.J.D. and Castro-Pastrana, L.I. and Rieder, M.J. and Shear, N.H. and Hayden, M.R. and Carleton, B.C.

De novo huntington disease caused by 26-44 CAG repeat expansion on a low-risk haplotype

Neurology

Houge, G. and Bruland, O. and Bj?rnevoll, I. and Hayden, M.R. and Semaka, A.

When access is an issue: Exploring barriers to predictive testing for Huntington disease in British Columbia, Canada

European Journal of Human Genetics

Hawkins, A.K. and Creighton, S. and Hayden, M.R.

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children

Pediatric Blood and Cancer

Visscher, H. and Ross, C.J.D. and Rassekh, S.R. and Sandor, G.S.S. and Caron, H.N. and van Dalen, E.C. and Kremer, L.C. and van der Pal, H.J. and Rogers, P.C. and Rieder, M.J. and Carleton, B.C. and Hayden, M.R.

Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145

Arteriosclerosis, Thrombosis, and Vascular Biology

Kang, M.H. and Zhang, L.-H. and Wijesekara, N. and De Haan, W. and Butland, S. and Bhattacharjee, A. and Hayden, M.R.

Providing predictive testing for Huntington disease via telehealth: Results of a pilot study in British Columbia, Canada

Clinical Genetics

Hawkins, A. and Creighton, S. and Ho, A. and Mcmanus, B. and Hayden, M.

Hunting human disease genes: Lessons from the past, challenges for the future

Human Genetics

Brunham, L.R. and Hayden, M.R.

8OHdG as a marker for Huntington disease progression

Neurobiology of Disease

Long, J.D. and Matson, W.R. and Juhl, A.R. and Leavitt, B.R. and Paulsen, J.S. and Wassink, T. and Cross, S. and Doucette, N. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E.A. and Beglinger, L.J. and Chiu, E. and Yastrubetskaya, O. and Preston, J. and Goh, A. and Fonseka, C. and Ronsisvalle, L. and Chua, P. and Komiti, A. and Raymond, L. and Santos, R.D. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Shpritz, B. and Welsh, C. and Mallonee, W.M. and Suter, G. and Addison, J. and Samii, A. and Macaraeg, A. and Jones, R. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and Goodman, A. and Swain, R. and Dipietro, A. and McCusker, E. and Griffith, J. and Loy, C. and Gunn, D. and Stewart, L. and Landwehrmeyer, B.G. and Orth, M. and S?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Karmalkar, I. and Perlman, S. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Kang, G. and Warner, T. and Burrows, M. and Novak, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Price, K. and Hunt, S. and Marshall, F. and Chesire, A. and Wodarski, M. and Hickey, C. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Panegyres, P. and Vuletich, E. and Andrew, S. and Zombor, R. and Perlmutter, J. and Barton, S. and Schmidt, A. and Miedzybrodzka, Z. and Simpson, S.A. and Rae, D. and D'alessandro, M. and Craufurd, D. and Fullam, R. and Howard, E. and Mazzoni, P. and Marder, K. and Wasserman, P. and Kumar, R. and Erickson, D. and Wheelock, V. and Tempkin, T. and Mans, N. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and de Yebenes, J.G. and Garde, M.B. and Fatas, M. and Martinez-Descales, A. and Martin, W. and King, P. and Sran, S. and Ahmed, A. and Rao, S. and Reece, C. and Zimbelman, J. and Bea, A. and Newman, E. and Bura, A. and Paulsen, J. and Johnson, H. and Smith, M.M. and Williams, J. and Beglinger, L. and Mills, J. and Aylward, E. and Biglan, K. and Macdonald, M. and Nance, M. and Erwin, C. and Hayden, M. and Didonato, S. and Evans, K. and Peterson, A. and Borowsky, B. and Juhl, A. and Weir, D. and Vonsattell, J.P. and Moskowitz, C. and Leserman, A. and Schaul, L. and Vik, S. and Harrington, D. and Castillo, G. and Morison, J. and Reed, J. and Diaz, M. and Dobbins, I. and Hershey, T. and Foster, E. and Moore, D. and Westervelt, H. and Davis, J. and Tremont, G. and Moser, D.J. and Rowe, K. and Theriault, D. and Gehl, C. and Matheson, K. and Siedlecki, K. and Van Walsem, M. and Bonner, S. and Elias, G. and Faust, M. and Borowski, B. and Carlozzi, N. and Duff, K. and Georgiou-Karistianis, N. and Stout, J. and Lange, H. and Papp, K. and Ro, E. and Clark, L.A. and Downing, N. and Laing, J. and Rees, K. and Ready, R. and Vaccarino, A. and Farias, S. and Gusella, J. and Myers, R. and Juhl, A. and Wang, K. and Ross, C. and Pierson, R. and Jones, K. and Marietta, J. and McDowell, W. and Harris, G. and Kim, E.Y. and Ashburner, J. and Potkin, S. and Toga, A. and Axelson, E. and Miller, M. and Reading, S. and Beg, M.F. and Magnotta, V.A. and Helmer, K. and Lim, K. and Lowe, M. and Mori, S. and Song, A. and Turner, J. and Beall, E. and Koenig, K. and Phillips, M. and Bryant, A. and Corey-Bloom, J. and Reilmann, R. and Unds, Z. and Fiedorowicz, J. and Robinson, R. and Ruggle, A. and Liu, D. and Anderson, K. and Groves, M. and Rickards, H. and van Duijn, E. and Antonijevic, I. and Giuliano, J. and Lu, W. and Lourens, S. and Zhang, Y. and Kimble, M. and Thumma, K. and Waterman, E. and Hinkel, J. and Schaul, L. and Hughes, L. and Connell, R.J. and Pease, K. and Rogers, B. and Smith, J. and Wu, S. and Zschiegner, R. and Carney, E. and McKirgan, B. and Scully, M. and Wyse, R. and Bockholt, J. and Werling-Witkoske, C. and Anderson, K. and Rapp, J. and Dudler, A. and Schumacher, J. and Thompson, S. and Davis, L. and Henneberry, M. and Ennis, G. and Blanchard, S. and Montross, K. and Danzer, P.

What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration

Clinical Genetics

Ketelaar, M.E. and Hofstra, R.M.W. and Hayden, M.R.

Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers

Clinical Pharmacology and Therapeutics

Sistonen, J. and Madadi, P. and Ross, C.J. and Yazdanpanah, M. and Lee, J.W. and Landsmeer, M.L.A. and Nauta, M. and Carleton, B.C. and Koren, G. and Hayden, M.R.

Population stratiWcation may bias analysis of PGC-1a as a modiWer of age at Huntington disease motor onset

Human Genetics

Ramos, E.M. and Latourelle, J.C. and Lee, J.-H. and Gillis, T. and Mysore, J.S. and Squitieri, F. and Di Pardo, A. and Di Donato, S. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Marder, K. and Gusella, J.F. and Lee, J.-M. and Alonso, I. and Sequeiros, J. and Myers, R.H. and MacDonald, M.E.

Caspase-6-resistant mutant huntingtin does not rescue the toxic effects of caspase-cleavable mutant huntingtin in vivo

Journal of Huntington's Disease

Graham, R.K. and Deng, Y. and Pouladi, M.A. and Vaid, K. and Ehrnhoefer, D. and Southwell, A.L. and Bissada, N. and Franciosi, S. and Hayden, M.R.

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

Journal of Neuroscience

Waldron-Roby, E. and Ratovitski, T. and Wang, X. and Jiang, M. and Watkin, E. and Arbez, N. and Graham, R.K. and Hayden, M.R. and Hou, Z. and Mori, S. and Swing, D. and Pletnikov, M. and Duan, W. and Tessarollo, L. and Ross, C.A.

Polyglutamine diseases and the risk of cancer

The Lancet Oncology

Pouladi, M.A. and Hayden, M.R.

Pharmacogenetics of Warfarin in Children

Pharmacoepidemiology and Drug Safety

Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S. R. and Ross, C. J. and Hayden, M. R. and Carleton, B. C.

miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets

Diabetes

Wijesekara, N. and Zhang, L.-H. and Kang, M.H. and Abraham, T. and Bhattacharjee, A. and Warnock, G.L. and Verchere, C.B. and Hayden, M.R.

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

Human Molecular Genetics

Pouladi, M.A. and Stanek, L.M. and Xie, Y. and Franciosi, S. and Southwell, A.L. and Deng, Y. and Butland, S. and Zhang, W. and Cheng, S.H. and Shihabuddin, L.S. and Hayden, M.R.

Human Mendelian pain disorders: A key to discovery and validation of novel analgesics

Clinical Genetics

Goldberg, Y. and Pimstone, S. and Namdari, R. and Price, N. and Cohen, C. and Sherrington, R. and Hayden, M.

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin

Pharmacogenomics Journal

Brunham, L.R. and Lansberg, P.J. and Zhang, L. and Miao, F. and Carter, C. and Hovingh, G.K. and Visscher, H. and Jukema, J.W. and Stalenhoef, A.F. and Ross, C.J.D. and Carleton, B.C. and Kastelein, J.J.P. and Hayden, M.R.

Treatment of Na v1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

Pain

Goldberg, Y.P. and Price, N. and Namdari, R. and Cohen, C.J. and Lamers, M.H. and Winters, C. and Price, J. and Young, C.E. and Verschoof, H. and Sherrington, R. and Pimstone, S.N. and Hayden, M.R.

Personalized Medicine: Temper Expectations Response

Science

Brunham, L. R. and Hayden, M. R.

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

Neurobiology of Disease

Pouladi, M.A. and Brillaud, E. and Xie, Y. and Conforti, P. and Graham, R.K. and Ehrnhoefer, D.E. and Franciosi, S. and Zhang, W. and Poucheret, P. and Compte, E. and Maurel, J.-C. and Zuccato, C. and Cattaneo, E. and Nri, C. and Hayden, M.R.

Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired -cell function

Diabetes

Kruit, J.K. and Wijesekara, N. and Westwell-Roper, C. and Vanmierlo, T. and De Haan, W. and Bhattacharjee, A. and Tang, R. and Wellington, C.L. and LtJohann, D. and Johnson, J.D. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.

Economic impact of a genetic test for cisplatin-induced ototoxicity

Pharmacogenomics Journal

Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.

Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region

American Journal of Human Genetics

Lee, J.-M. and Gillis, T. and Mysore, J.S. and Ramos, E.M. and Myers, R.H. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Squitieri, F. and Griguoli, A. and Di Donato, S. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Sequeiros, J. and MacDonald, M.E. and Gusella, J.F.

Age-dependent resistance to excitotoxicity in Htt CAG140 mice and the effect of strain background

Journal of Huntington's Disease

Strong, M.K. and Southwell, A.L. and Yonan, J.M. and Hayden, M.R. and Macgregor, G.R. and Thompson, L.M. and Steward, O.

Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Tietjen, I. and Hovingh, G.K. and Singaraja, R. and Radomski, C. and McEwen, J. and Chan, E. and Mattice, M. and Legendre, A. and Kastelein, J.J.P. and Hayden, M.R.

Development of the Huntington disease work function scale

Journal of Occupational and Environmental Medicine

Brossman, B. and Williams, J.K. and Downing, N. and Mills, J.A. and Paulsen, J.S. and Wassink, T. and Cross, S. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E.A. and Beglinger, L.J. and Chiu, E. and Yastrubetskaya, O. and Preston, J. and Goh, A. and Fonseka, C. and Antonopoulos, S. and Loi, S. and Chua, P. and Komiti, A. and Raymond, L. and Dar Santos, R. and Carter, K. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Shpritz, B. and Yoritomo, N. and Welsh, C. and Mallonee, W.M. and Suter, G. and Addison, J. and Samii, A. and Macaraeg, A. and Jones, R. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and Goodman, A. and Dipietro, A. and McCusker, E. and Griffith, J. and Loy, C. and Gunn, D. and Landwehrmeyer, B.G. and Orth, M. and S?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Karmalkar, I. and Perlman, S. and Clemente, B. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Kang, G. and Warner, T. and Burrows, M. and Novak, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Price, K. and Hunt, S. and Marshall, F. and Chesire, A. and Wodarski, M. and Hickey, C. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Panegyres, P. and Lee, J. and Andrew, S. and Perlmutter, J. and Barton, S. and Schmidt, A. and Miedzybrodzka, Z. and Rae, D. and D?alessandro, M. and Craufurd, D. and Fullam, R. and Bek, J. and Howard, E. and Mazzoni, P. and Marder, K. and Wasserman, P. and Kumar, R. and Erickson, D. and Wheelock, V. and Tempkin, T. and Kjer, L. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and Martin, W. and King, P. and Wieler, M. and Sran, S. and Ahmed, A. and Rao, S. and Reece, C. and Zimbelman, J. and Bea, A. and Newman, E. and Bura, A. and Mourany, L. and Schulz, J. and Paulsen, J. and Johnson, H. and Smith, M. and Williams, J. and Long, J.D. and Aylward, E. and Biglan, K. and Leavitt, B. and Macdonald, M. and Nance, M. and Erwin, C. and Hayden, M. and Didonato, S. and Evans, K. and Matson, W. and Peterson, A. and Borowsky, B. and Juhl, A. and Wang, K. and Weir, D. and Vonsattell, J.P. and Moskowitz, C. and Leserman, A. and Schaul, L. and Vik, S. and Harrington, D. and Castillo, G. and Morison, J. and Reed, J. and Diaz, M. and Dobbins, I. and Hershey, T. and Foster, E. and Moore, D. and Westervelt, H. and Davis, J. and Tremont, G. and Moser, D.J. and Rowe, K. and Wenman, G. and Theriault, D. and Gehl, C. and Matheson, K. and Siedlecki, K. and Van Walsem, M. and Bonner, S. and Elias, G. and Gover, M. and Bernier, R. and Faust, M. and Borowski, B. and Carlozzi, N. and Duff, K. and Georgiou-Karistianis, N. and Stout, J. and Lange, H. and Papp, K. and Ro, E. and Clark, L.A. and Laing, J. and Rees, K. and Harreld, M. and Ready, R. and Vaccarino, A. and Farias, S. and Gusella, J. and Myers, R. and Juhl, A. and Pierson, R. and Jones, K. and Marietta, J. and McDowell, W. and Harris, G. and Kim, E.Y. and Ashburner, J. and Potkin, S. and Toga, A. and Axelson, E. and Miller, M. and Reading, S. and Beg, M.F. and Magnotta, V.A. and Helmer, K. and Lim, K. and Lowe, M. and Mori, S. and Song, A. and Turner, J. and Rao, S. and Beall, E. and Koenig, K. and Phillips, M. and Bryant, A. and Corey-Bloom, J. and Geschwind, M. and Reilmann, R. and Unds, Z. and Fiedorowicz, J. and Robinson, R. and Ruggle, A. and Liu, D. and Moser, D. and Anderson, K. and Groves, M. and Rickards, H. and van Duijn, E. and Kim, J.-I. and Harrison, B. and Zhang, Y. and Lu, W. and Lourens, S. and Doucette, N. and Thumma, K. and Waterman, E. and Hinkel, J. and Hughes, L. and Connell, R.J. and Pease, K. and Rogers, B. and Smith, J. and Wu, S. and Zschiegner, R. and Carney, E. and McKirgan, B. and Scully, M. and Wyse, R. and Bockholt, J. and Werling-Witkoske, C. and Ennis, G. and Anderson, K. and Rapp, J. and Thompson, S. and Davis, L. and Henneberry, M. and Dudler, A. and Schumacher, J. and Stout, C. and Blanchard, S. and Montross, K. and Danzer, P.

Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia

Journal of Pediatrics

Lam, J. and Kelly, L. and Ciszkowski, C. and Landsmeer, M.L.A. and Nauta, M. and Carleton, B.C. and Hayden, M.R. and Madadi, P. and Koren, G.

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

Neurology

Lee, J.-M. and Ramos, E.M. and Lee, J.-H. and Gillis, T. and Mysore, J.S. and Hayden, M.R. and Warby, S.C. and Morrison, P. and Nance, M. and Ross, C.A. and Margolis, R.L. and Squitieri, F. and Orobello, S. and Di Donato, S. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J.A. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Sequeiros, J. and Paulsen, J.S. and Landwehrmeyer, G.B. and Myers, R.H. and MacDonald, M.E. and Gusella, J.F.

Apnea and oxygen desaturations in children treated with opioids after adenotonsillectomy for obstructive sleep apnea syndrome: A prospective pilot study

Pediatric Drugs

Khetani, J.D. and Madadi, P. and Sommer, D.D. and Reddy, D. and Sistonen, J. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.

Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases

Progress in Neurobiology

Young, F.B. and Butland, S.L. and Sanders, S.S. and Sutton, L.M. and Hayden, M.R.

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: The devil is in the details

Therapeutic Drug Monitoring

Lam, J. and Matlow, J.N. and Ross, C.J.D. and Hayden, M.R. and Carleton, B.C. and Madadi, P.

Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children

Journal of Clinical Oncology

Visscher, H. and Ross, C.J.D. and Rassekh, S.R. and Barhdadi, A. and Dub, M.-P. and Al-Saloos, H. and Sandor, G.S. and Caron, H.N. and Van Dalen, E.C. and Kremer, L.C. and Van Der Pal, H.J. and Brown, A.M.K. and Rogers, P.C. and Phillips, M.S. and Rieder, M.J. and Carleton, B.C. and Hayden, M.R.

Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice

PLoS ONE

Young, F.B. and Franciosi, S. and Spreeuw, A. and Deng, Y. and Sanders, S. and Tam, N.C.M. and Huang, K. and Singaraja, R.R. and Zhang, W. and Bissada, N. and Kay, C. and Hayden, M.R.

Apnea and Oxygen Desaturations in Children Treated with Opioids after Adenotonsillectomy for Obstructive Sleep Apnea Syndrome A Prospective Pilot Study

Pediatric Drugs

Khetani, J. D. and Madadi, P. and Sommer, D. D. and Reddy, D. and Sistonen, J. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R. and Koren, G.

Adoption and the communication of genetic risk: Experiences in Huntington disease

Clinical Genetics

Bombard, Y. and Semaka, A. and Hayden, M.R.

TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease

Biochemical and Biophysical Research Communications

Lee, J.-H. and Lee, J.-M. and Ramos, E.M. and Gillis, T. and Mysore, J.S. and Kishikawa, S. and Hadzi, T. and Hendricks, A.E. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Squitieri, F. and Gellera, C. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Sequeiros, J. and Bernhard Landwehrmeyer, G. and Shoulson, I. and Myers, R.H. and MacDonald, M.E. and Gusella, J.F.

PHARMACOGENETIC INSIGHT INTO OXYCODONE: IMPLICATIONS TO BREASTFEEDING MOTHERS AND NEONATES DURING THE POSTPARTUM PERIOD

Clinical Pharmacology & Therapeutics

Lam, J. and Madadi, P. and Matok, I. and Kelly, L. and Carleton, B. C. and Hayden, M. R. and Koren, G.

Beyond the patient: The broader impact of genetic discrimination among individuals at risk of huntington disease

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Bombard, Y. and Palin, J. and Friedman, J.M. and Veenstra, G. and Creighton, S. and Bottorff, J.L. and Hayden, M.R. and Guttman, M. and Giambattista, C. and Ludman, M. and Murphy, J. and Babineau-Sturk, T. and MacLeod, P. and Rice, J. and Martin, W. and Wieler, M. and Meschino, W. and Gibbons, C. and Raymond, L. and Decolongon, J. and Suchowersky, O. and Klimek, M.-L.

Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases

Trends in Molecular Medicine

Southwell, A.L. and Skotte, N.H. and Bennett, C.F. and Hayden, M.R.

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol

PLoS ONE

Tietjen, I. and Hovingh, G.K. and Singaraja, R.R. and Radomski, C. and Barhdadi, A. and McEwen, J. and Chan, E. and Mattice, M. and Legendre, A. and Franchini, P.L. and Dub, M.-P. and Kastelein, J.J.P. and Hayden, M.R.

Cognitive domains that predict time to diagnosis in prodromal Huntington disease

Journal of Neurology, Neurosurgery and Psychiatry

Harrington, D.L. and Smith, M.M. and Zhang, Y. and Carlozzi, N.E. and Paulsen, J.S. and Wassink, T. and Cross, S. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E.A. and Beglinger, L.J. and Chiu, E. and Yastrubetskaya, O. and Preston, J. and Goh, A. and Fonseka, C. and Antonopoulos, S. and Loi, S. and Chua, P. and Komiti, A. and Raymond, L. and Dar Santos, R. and Carter, K. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Shpritz, B. and Yoritomo, N. and Welsh, C. and Mallonee, W.M. and Suter, G. and Addison, J. and Samii, A. and Macaraeg, A. and Jones, R. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and Goodman, A. and Dipietro, A. and McCusker, E. and Griffith, J. and Loy, C. and Gunn, D. and Landwehrmeyer, B.G. and Orth, M. and S?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Karmalkar, I. and Perlman, S. and Clemente, B. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Kang, G. and Warner, T. and Burrows, M. and Novak, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Price, K. and Hunt, S. and Marshall, F. and Chesire, A. and Wodarski, M. and Hickey, C. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Panegyres, P. and Lee, J. and Andrew, S. and Perlmutter, J. and Barton, S. and Schmidt, A. and Miedzybrodzka, Z. and Rae, D. and D?alessandro, M. and Craufurd, D. and Fullam, R. and Bek, J. and Howard, E. and Mazzoni, P. and Marder, K. and Wasserman, P. and Kumar, R. and Erickson, D. and Wheelock, V. and Tempkin, T. and Kjer, L. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and Martin, W. and King, P. and Wieler, M. and Sran, S. and Ahmed, A. and Rao, S. and Reece, C. and Zimbelman, J. and Bea, A. and Newman, E. and Bura, A. and Mourany, L. and Schulz, J. and Johnson, H. and Williams, J. and Beglinger, L. and Long, J.D. and Mills, J.A. and Aylward, E. and Biglan, K. and Leavitt, B. and Macdonald, M. and Nance, M. and Erwin, C. and Hayden, M. and Didonato, S. and Evans, K. and Matson, W. and Peterson, A. and Borowsky, B. and Juhl, A. and Wang, K. and Weir, D. and Vonsattell, J.P. and Moskowitz, C. and Leserman, A. and Schaul, L. and Vik, S. and Castillo, G. and Morison, J. and Reed, J. and Diaz, M. and Dobbins, I. and Hershey, T. and Foster, E. and Moore, D. and Westervelt, H. and Davis, J. and Tremont, G. and Moser, D.J. and Rowe, K. and Wenman, G. and Theriault, D. and Gehl, C. and Matheson, K. and Siedlecki, K. and Van Walsem, M. and Bonner, S. and Elias, G. and Gover, M. and Bernier, R. and Faust, M. and Borowski, B. and Duff, K. and Georgiou-Karistianis, N. and Stout, J. and Lange, H. and Papp, K. and Ro, E. and Clark, L.A. and Downing, N. and Laing, J. and Rees, K. and Harreld, M. and Ready, R. and Vaccarino, A. and Farias, S. and Gusella, J. and Myers, R. and Mills, J. and Pierson, R. and Jones, K. and Marietta, J. and McDowell, W. and Harris, G. and Kim, E.Y. and Ashburner, J. and Potkin, S. and Toga, A. and Axelson, E. and Miller, M. and Reading, S. and Beg, M.F. and Magnotta, V.A. and Helmer, K. and Lim, K. and Lowe, M. and Mori, S. and Song, A. and Turner, J. and Beall, E. and Koenig, K. and Phillips, M. and Bryant, A. and Corey-Bloom, J. and Reilmann, R. and Unds, Z. and Fiedorowicz, J. and Robinson, R. and Ruggle, A. and Liu, D. and Anderson, K. and Groves, M. and Rickards, H. and van Duijn, E. and Kim, J.-I. and Harrison, B. and Lu, W. and Lourens, S. and Doucette, N. and Thumma, K. and Waterman, E. and Hinkel, J. and Hughes, L. and Connell, R.J. and Pease, K. and Rogers, B. and Smith, J. and Wu, S. and Zschiegner, R. and Carney, E. and McKirgan, B. and Scully, M. and Wyse, R. and Bockholt, J. and Werling-Witkoske, C. and Ennis, G. and Bjork, K. and Thompson, S. and Davis, L. and Henneberry, M. and Dudler, A. and Schumacher, J. and Stout, C. and Blanchard, S. and Montross, K. and Danzer, P.

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

Neurobiology of Disease

Franciosi, S. and Ryu, J.K. and Shim, Y. and Hill, A. and Connolly, C. and Hayden, M.R. and McLarnon, J.G. and Leavitt, B.R.

Whole-genome sequencing: The new standard of care?

Science

Brunham, L.R. and Hayden, M.R.

Response

Science

Brunham, L.R. and Hayden, M.R.

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

Human Molecular Genetics

Uribe, V. and Wong, B.K.Y. and Graham, R.K. and Cusack, C.L. and Skotte, N.H. and Pouladi, M.A. and Xie, Y. and Feinberg, K. and Ou, Y. and Ouyang, Y. and Deng, Y. and Franciosi, S. and Bissada, N. and Spreeuw, A. and Zhang, W. and Ehrnhoefer, D.E. and Vaid, K. and Miller, F.D. and Deshmukh, M. and Howland, D. and Hayden, M.R.

Peripheral and cerebral metabolic features in an animal model of Huntington's disease

2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012

Lopes, C. and Duarte, A.I. and Hayden, M. and Rego, A.C.

More codeine fatalities after tonsillectomy in North American children

Pediatrics

Kelly, L.E. and Rieder, M. and Van Den Anker, J. and Malkin, B. and Ross, C. and Neely, M.N. and Carleton, B. and Hayden, M.R. and Madadi, P. and Koren, G.

Erratum: Economic impact of a genetic test for cisplatin-induced ototoxicity (The Pharmacogenomics Journal (2012) 12 (205-213) DOI: 10.1038/tpj.2011.15)

Pharmacogenomics Journal

Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.

Cutaneous adverse drug reactions in children: An analysis of reports from the Canadian Pharmacogenomics Network for drug safety (CPNDS)

Journal of Population Therapeutics and Clinical Pharmacology

Castro-Pastrana, L.I. and Ghannadan, R. and Rieder, M.J. and Dahlke, E. and Hayden, M. and Carleton, B.

Caspase-6 and neurodegeneration

Trends in Neurosciences

Graham, R.K. and Ehrnhoefer, D.E. and Hayden, M.R.

A grand challenge: Providing benefits of clinical genetics to those in need

Genetics in Medicine

Hawkins, A.K. and Hayden, M.R.

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14

Human Molecular Genetics

Huang, K. and Sanders, S.S. and Kang, R. and Carroll, J.B. and Sutton, L. and Wan, J. and Singaraja, R. and Young, F.B. and Liu, L. and El-Husseini, A. and Davis, N.G. and Hayden, M.R.

The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice

American Journal of Pathology

Ye, D. and Zhao, Y. and Hildebrand, R.B. and Singaraja, R.R. and Hayden, M.R. and Van Berkel, T.J.C. and Van Eck, M.

Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics

Journal of Cardiovascular Pharmacology

Visscher, H. and Amstutz, U. and Sistonen, J. and Ross, C.J. and Hayden, M.R. and Carleton, B.C.

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

Molecular Neurodegeneration

Carroll, J.B. and Southwell, A.L. and Graham, R.K. and Lerch, J.P. and Ehrnhoefer, D.E. and Cao, L.-P. and Zhang, W.-N. and Deng, Y. and Bissada, N. and Henkelman, R. and Hayden, M.R.

Diagnostic testing for vaccinomics: Is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe

OMICS A Journal of Integrative Biology

Joly, Y. and Koutrikas, G. and Ramos-Paque, E. and Zawati, M. and Gardy, J. and Hayden, M.R. and Carleton, B.C.

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

Human Molecular Genetics

Singaraja, R.R. and Huang, K. and Sanders, S.S. and Milnerwood, A.J. and Hines, R. and Lerch, J.P. and Franciosi, S. and Drisdel, R.C. and Vaid, K. and Young, F.B. and Doty, C. and Wan, J. and Bissada, N. and Henkelman, R.M. and Green, W.N. and Davis, N.G. and Raymond, L.A. and Hayden, M.R.

Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease

Neurobiology of Disease

Carroll, J.B. and Lerch, J.P. and Franciosi, S. and Spreeuw, A. and Bissada, N. and Henkelman, R.M. and Hayden, M.R.

The communication of pharmacogenetic research results: Participants weigh in on their informational needs in a pilot study

Journal of Population Therapeutics and Clinical Pharmacology

Madadi, P. and Joly, Y. and Avard, D. and Chitayat, D.C. and Smith, M.A. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.

Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the huntington disease gene / allele-specific silencing of mutant huntingtin

Molecular Therapy

Carroll, J.B. and Warby, S.C. and Southwell, A.L. and Doty, C.N. and Greenlee, S. and Skotte, N. and Hung, G. and Bennett, C.F. and Freier, S.M. and Hayden, M.R.

Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans

Clinical Genetics

Brunham, L.R. and Tietjen, I. and Bochem, A.E. and Singaraja, R.R. and Franchini, P.L. and Radomski, C. and Mattice, M. and Legendre, A. and Hovingh, G.K. and Kastelein, J.J.P. and Hayden, M.R.

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

Nature Medicine

Song, W. and Chen, J. and Petrilli, A. and Liot, G. and Klinglmayr, E. and Zhou, Y. and Poquiz, P. and Tjong, J. and Pouladi, M.A. and Hayden, M.R. and Masliah, E. and Ellisman, M. and Rouiller, I. and Schwarzenbacher, R. and Bossy, B. and Perkins, G. and Bossy-Wetzel, E.

Cholesterol metabolism in Huntington disease

Nature Reviews Neurology

Karasinska, J.M. and Hayden, M.R.

Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL

PLoS ONE

Ding, Y. and Zhang, L. and Wang, Y. and Huang, W. and Tang, Y. and Bai, L. and Ross, C.J.D. and Hayden, M.R. and Liu, G.

A quantitative method for the specific assessment of caspase-6 activity in cell culture

PLoS ONE

Ehrnhoefer, D.E. and Skotte, N.H. and Savill, J. and Nguyen, Y.T.N. and Ladha, S. and Cao, L.-P. and Dullaghan, E. and Hayden, M.R.

Pharmacogenomics of serious adverse drug reactions in pediatric oncology

Journal of Population Therapeutics and Clinical Pharmacology

Ross, C.J.D. and Visscher, H. and Rod Rassekh, S. and Castro-Pastrana, L.I. and Shereck, E. and Carleton, B. and Hayden, M.R.

HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia

European Journal of Human Genetics

Warby, S.C. and Visscher, H. and Collins, J.A. and Doty, C.N. and Carter, C. and Butland, S.L. and Hayden, A.R. and Kanazawa, I. and Ross, C.J. and Hayden, M.R.

CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: A pilot study

Therapeutic Drug Monitoring

VanderVaart, S. and Berger, H. and Sistonen, J. and Madadi, P. and Matok, I. and Gijsen, V.M.G.J. and De Wildt, S.N. and Taddio, A. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease

Neurobiology of Disease

Simpson, J.M. and Gil-Mohapel, J. and Pouladi, M.A. and Ghilan, M. and Xie, Y. and Hayden, M.R. and Christie, B.R.

Regulatory approval for new pharmacogenomic tests: A comparative overview

Food and Drug Law Journal

Joly, Y. and Koutrikas, G. and Tass, A.-M. and Issa, A. and Carleton, B. and Hayden, M. and Rieder, M.J. and Ramos-Paque, E. and Avard, D.

Lessons from predictive testing for Huntington disease: 25 years on

Journal of Medical Genetics

Hawkins, A.K. and Ho, A. and Hayden, M.R.

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: Shared targets for drug development

Nature Reviews Drug Discovery

Ehrnhoefer, D.E. and Wong, B.K.Y. and Hayden, M.R.

An interaction of genes in our social environment: Genetic discrimination among persons at risk for huntington disease

Challenging Genetic Determinism: New Perspectives on the Gene in Its Multiple Environments

Bombard, Y. and Hayden, M.R.

Small changes, big impact: Posttranslational modifications and function of huntingtin in huntington disease

Neuroscientist

Ehrnhoefer, D.E. and Sutton, L. and Hayden, M.R.

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules

Diabetes

Kruit, J.K. and Wijesekara, N. and Manning Fox, J.E. and Dai, X.-Q. and Brunham, L.R. and Searle, G.J. and Morgan, G.P. and Costin, A.J. and Tang, R. and Bhattacharjee, A. and Johnson, J.D. and Light, P.E. and Marsh, B.J. and MacDonald, P.E. and Verchere, C.B. and Hayden, M.R.

Factors associated with experiences of genetic discrimination among individuals at risk for huntington disease

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Bombard, Y. and Palin, J.A. and Friedman, J.M. and Veenstra, G. and Creighton, S. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R. and Guttman, M. and Giambattista, C. and Ludman, M. and Murphy, J. and Babineau-Sturk, T. and MacLeod, P. and Rice, J. and Martin, W. and Wieler, M. and Meschino, W. and Gibbons, C. and Raymond, L. and Decolongon, J. and Suchowersky, O. and Klimek, M.-L.

Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: A pilot study of perceptions and benefits

Clinical Pharmacology and Therapeutics

Madadi, P. and Joly, Y. and Avard, D. and Chitayat, D.C. and Smith, M.A. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

Human Molecular Genetics

Becanovic, K. and Pouladi, M.A. and Lim, R.S. and Kuhn, A. and Pavlidis, P. and Luthi-Carter, R. and Hayden, M.R. and Leavitt, B.R.

Dynamics of Macrophage Infiltration into the Arterial Wall at Different Stages of Atherosclerotic Lesion Development and Dependency on Macrophage ABCA1 Expression

Circulation

Ye, D. and Hildebrand, R. B. and Singaraja, R. R. and Hayden, M. R. and van Berkel, T. J. and Van Eck, M.

Cocaine adulterant linked to neutropenia

CMAJ

Wiens, M.O. and Son, W.K. and Ross, C. and Hayden, M. and Carleton, B.

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

Diabetologia

Kruit, J.K. and Kremer, P.H.C. and Dai, L. and Tang, R. and Ruddle, P. and De Haan, W. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.

Challenges assessing clinical endpoints in early Huntington disease

Movement Disorders

Paulsen, J.S. and Wang, C. and Duff, K. and Barker, R. and Nance, M. and Beglinger, L. and Moser, D. and Williams, J.K. and Simpson, S. and Langbehn, D. and van Kammen, D.P. and Paulson, H. and Bastic, K. and Conybeare, R. and Humphreys, C. and Elbert, M. and Nopoulos, P. and Rodnitzky, R. and Uc, E. and Beglinger, L. and Duff, K. and Magnotta, V.A. and Cross, S. and Doucette, N. and French, S. and Hale, N. and Juhl, A. and Kuburas, H. and Mikos, A. and Reese, B. and Turner, B. and Van Der Heiden, S. and Ames, D. and Chiu, E. and Chua, P. and Yastrubetskaya, O. and Dingjan, P. and Draper, K. and Georgiou-Karistianis, N. and Goh, A. and Komiti, A. and Lemmon, C. and Raymond, L. and Decolongon, J. and Rosenblatt, A. and Ross, C. and Agarwal, A. and Gourley, L. and Shpritz, B. and Wajda, K. and Welsh, C. and Bakker, A. and Miller, R. and Mallonee, W.M. and Suter, G. and Palmer, D. and Addison, J. and Samii, A. and Lipe, H. and Bird, T. and Logsdon, R. and Weaver, K. and Field, K. and Jones, R. and Harrison, J. and Ingram, C. and Wood-Siverio, C. and Factor, S.A. and Timothy Greenamyre, J. and Testa, C. and Barker, R.A. and Mason, S. and Smith, E. and Wright, B. and McCusker, E. and Griffith, J. and Bibb, B. and Hayes, C. and Richardson, K. and Graham, S. and Landwehrmeyer, B.G. and Barth, K. and Niess, A. and Trautmann, S. and Ecker, D. and Held, C. and Weydt, P. and Orth, M. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Elliott, S. and Fonariov, Z. and Giambattista, C. and Russell, S. and Sebastian, J. and Sethna, R. and Ip, R. and Shaddick, D. and Sheinberg, A. and Stober, J. and Perlman, S. and Carroll, R. and Johnson, A. and Jackson, G. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Rose, K. and Wyss-Coray, C. and Kramer, J. and Sha, S. and Wetzel, M. and Warner, T. and Kloppel, S. and Burrows, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Golding, C. and Rosser, A. and Naji, J. and Price, K. and Handley, O.J. and Como, P. and Chesire, A. and Hickey, C. and Zimmerman, C. and Couniham, T. and Marshall, F. and Burton, C. and Wodarski, M. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Kirstein, D. and Rosas, D. and Bennett, M. and Frishman, J. and Kaneko, Y. and Landau, T. and Lausier, M. and Muir, L. and Murphy, L. and Young, A. and Skeuse, C. and Balkema, N. and Hoogenboom, W. and Leveroni, C. and Sherman, J. and Zaleta, A. and Panegyres, P. and Connor, C. and Vuletich, E. and Woodman, M. and Zombor, R. and Perlmutter, J. and Barton, S. and Kavanaugh, M. and Simpson, S.A. and Keenan, G. and Ure, A. and Summers, F. and Craufurd, D. and Fullam, R. and Macleod, R. and Sollom, A. and Howard, E. and Mazzoni, P. and Marder, K. and Williamson, J. and Moskowitz, C. and Wasserman, P. and Seeberger, L. and Diamond, A. and Erickson, D. and Judd, D. and Kasunic, T.L. and Mellick, L. and Miracle, D. and Greenwald, C. and Malleck, K. and Montellano, S. and Kumar, R. and Schneiders, J. and Wheelock, V. and Tempkin, T. and Marsano, J. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and Martin, C. and de Yebenes, J.G. and Garde, M.B. and Fatas, M. and Schwartz, C. and Sendon, J.L. and Trigo, P.M. and Nance, M. and Radtke, D. and Norberg, D. and Tupper, D. and Martin, W. and King, P. and Wieler, M. and Foster, S. and Sran, S. and Dubinsky, R. and Gray, C. and Switzer, P. and Paulsen, J. and Johnson, H. and Aylward, E. and Biglan, K. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Guttman, M. and Hayden, M. and Landwehrmeyer, B.G. and Nance, M. and Ross, C. and Stout, J.C. and Stout, J.C. and Blanchard, S. and Anderson, C. and Dudler, A. and Henneberry, M. and Montross, K. and O'brien, P. and Penziner, E. and Leserman, A. and Ludwig, B. and McAreavy, B. and Mills, J.A. and Murray, G. and Nehl, C. and Vik, S. and Wang, C. and Werling-Witkoske, C. and Bourgeois, K. and Covert, C. and Daigneault, S. and Julian-Baros, E. and Meyers, K. and Rothenburgh, K. and Olsen, B. and Orme, C. and Ross, T. and Simone, M. and Weber, J. and Zhao, H. and Queller, S. and Johnson, S.A. and Colin Campbell, J. and Peters, E. and Carlozzi, N.E. and Green, T. and Swain, S.N. and Caughlin, D. and Ward-Bluhm, B. and Whitlock, K. and Paulsen, J. and Penziner, E. and Vik, S. and Agarwal, A. and Barnes, A. and Suter, G. and Jones, R. and Griffith, J. and Lipe, H. and Barth, K. and Fox, M. and Guzijan, M. and Zanko, A. and Naji, J. and Zombor, R. and Kavanaugh, M. and Chesire, A. and Julian-Baros, E. and Kayson, E. and Tempkin, T. and Nance, M. and Quaid, K. and Paulsen, J. and Coryell, W. and Ross, C. and Kayson, E. and Shinaman, A. and Tempkin, T. and Nance, M. and Quaid, K. and Erwin, C.

BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice

Journal of Neuroscience

Xie, Y. and Hayden, M.R. and Xu, B.

NP03, A LOW DOSE LITHIUM MICROEMULSION, IMPROVES MOTOR FUNCTION AND RESCUES STRIATAL PATHOLOGY WITHOUT TOXICITY IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE

Journal of Neurology Neurosurgery and Psychiatry

Pouladi, M. A. and Brilluad, E. and Xie, Y. and Franciosi, S. and Zhang, W. N. and Zapala, M. and Compte, E. and Poucheret, P. and Maurel, J. C. and Neri, C. and Hayden, M. R.

In their own words: Reports of stigma and genetic discrimination by people at risk for huntington disease in the international RESPOND-HD study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Williams, J.K. and Erwin, C. and Juhl, A.R. and Mengeling, M. and Bombard, Y. and Hayden, M.R. and Quaid, K. and Shoulson, I. and Taylor, S. and Paulsen, J.S. and Adams, W. and Elbert, M. and Chiu, E. and Goh, A. and Yastrubetskaya, O. and Agarwal, A. and Rosenblatt, A. and Welsh, C. and Marder, K. and Wasserman, P. and Moskowitz, C. and Decolongon, J. and Raymond, L.A. and Lipe, H. and Samii, A. and Williams, P. and Aylward, E. and Harrison, J.M. and Jones, R. and Wood-Siverio, C. and Wesson, M. and Biglan, K. and Chesire, A. and Como, P. and Giambattista, C. and Guttman, M. and Sheinberg, A. and Singer, A. and Griffith, J. and McCusker, E. and Richardson, K. and Tempkin, T. and Wheelock, V.L. and Johnson, A. and Linderholm, W. and Perlman, S. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Chua, P. and Komiti, A. and Panegyres, P. and Vuletich, E. and Woodman, M.

HDL and LDL cholesterol significantly influence -cell function in type 2 diabetes mellitus

Current Opinion in Lipidology

Kruit, J.K. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.

Carriers of loss-of-function mutations in ABCA1 display pancreatic -cell dysfunction

Diabetes Care

Vergeer, M. and Brunham, L.R. and Koetsveld, J. and Kruit, J.K. and Verchere, C.B. and Kastelein, J.J.P. and Hayden, M.R. and Stroes, E.S.G.

Adenosine-triphosphate-binding cassette transporter-1 trafficking and function

Trends in Cardiovascular Medicine

Kang, M.H. and Singaraja, R. and Hayden, M.R.

The Canadian Pharmacogenomics Network for Drug Safety: a model for safety pharmacology.

Thyroid : official journal of the American Thyroid Association

Ross, C.J. and Visscher, H. and Sistonen, J. and Brunham, L.R. and Pussegoda, K. and Loo, T.T. and Rieder, M.J. and Koren, G. and Carleton, B.C. and Hayden, M.R. and CPNDS Consortium

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia

Journal of Lipid Research

Olivecrona, G. and Ehrenborg, E. and Semb, H. and Makoveichuk, E. and Lindberg, A. and Hayden, M.R. and Gin, P. and Davies, B.S.J. and Weinstein, M.M. and Fong, L.G. and Beigneux, A.P. and Young, S.G. and Olivecrona, T. and Hernell, O.

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice (DOI:10.1016/j.neuron.2010.01.008)

Neuron

Milnerwood, A.J. and Gladding, C.M. and Pouladi, M.A. and Kaufman, A.M. and Hines, R.M. and Boyd, J.D. and Ko, R.W.Y. and Vasuta, O.C. and Graham, R.K. and Hayden, M.R. and Murphy, T.H. and Raymond, L.A.

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A

Journal of Neuroscience

Metzler, M. and Gan, L. and Mazarei, G. and Graham, R.K. and Liu, L. and Bissada, N. and Lu, G. and Leavitt, B.R. and Hayden, M.R.

Perception, experience, and response to genetic discrimination in Huntington disease: The international RESPOND-HD study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Erwin, C. and Williams, J.K. and Juhl, A.R. and Mengeling, M. and Mills, J.A. and Bombard, Y. and Hayden, M.R. and Quaid, K. and Shoulson, I. and Taylor, S. and Paulsen, J.S. and Adams, W. and Elbert, M. and Chiu, E. and Goh, A. and Yastrubetskaya, O. and Agarwal, A. and Rosenblatt, A. and Welsh, C. and Marder, K. and Wasserman, P. and Moskowitz, C. and Decolongon, J. and Raymond, L.A. and Lipe, H. and Samii, A. and Williams, P. and Aylward, E. and Harrison, J.M. and Jones, R. and Wood-Siverio, C. and Wesson, M. and Biglan, K. and Chesire, A. and Como, P. and Giambattista, C. and Guttman, M. and Sheinberg, A. and Singer, A. and Griffith, J. and McCusker, E. and Richardson, K. and Tempkin, T. and Wheelock, V.L. and Johnson, A. and Linderholm, W. and Perlman, S. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Chua, P. and Komiti, A. and Panegyres, P. and Vuletich, E. and Woodman, M.

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

Neuron

Milnerwood, A.J. and Gladding, C.M. and Pouladi, M.A. and Kaufman, A.M. and Hines, R.M. and Boyd, J.D. and Ko, R.W.Y. and Vasuta, O.C. and Graham, R.K. and Hayden, M.R. and Murphy, T.H. and Raymond, L.A.

Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice. Reply to: De Souza JC, de Oliveira CAM, Carneiro em et al. [letter]

Diabetologia

Kruit, J.K. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.

CASPASE 6 RESISTANT MUTANT HUNTINGTIN DOES NOT RESCUE THE TOXIC EFFECTS OF CASPASE CLEAVABLE MUTANT HUNTINGTIN IN VIVO

Journal of Neurology Neurosurgery and Psychiatry

Graham, R. K. and Deng, Y. and Pouladi, M. A. and Vaid, K. and Xie, Y. and Bissada, N. and Franciosi, S. and Hayden, M. R.

CAG-repeat length and the age of onset in Huntington Disease (HD): A review and validation study of statistical approaches

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Langbehn, D.R. and Hayden, M.R. and Paulsen, J.S. and Johnson, H. and Aylward, E. and Biglan, K. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Guttman, M. and Landwehrmeyer, B.G. and Nance, M. and Ross, C. and Stout, J.

Pharmacogenomics and active surveillance for serious adverse drug reactions in children

Pharmacogenomics

Loo, T.T. and Ross, C.J.D. and Sistonen, J. and Visscher, H. and Madadi, P. and Koren, G. and Hayden, M.R. and Carleton, B.C.

PHARMACOGENOMICS

Acta Paediatrica

Hayden, M. R.

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

Human Molecular Genetics

Pouladi, M.A. and Xie, Y. and Skotte, N.H. and Ehrnhoefer, D.E. and Graham, R.K. and Kim, J.E. and Bissada, N. and Yang, X.W. and Paganetti, P. and Friedlander, R.M. and Leavitt, B.R. and Hayden, M.R.

Fatal hydrocodone overdose in a child: Pharmacogenetics and drug interactions

Pediatrics

Madadi, P. and Hildebrandt, D. and Gong, I.Y. and Schwarz, U.I. and Ciszkowski, C. and Ross, C.J.D. and Sistonen, J. and Carleton, B.C. and Hayden, M.R. and Lauwers, A.E. and Koren, G.

Effects of Endothelial Lipase Loss-of-Function Mutations on HDLc Levels in the General Population

Arteriosclerosis Thrombosis and Vascular Biology

Tietjen, Ian and Singaraja, Roshni and Hovingh, G. Kees and Motazacker, M. Madhi and Kuivenhoven, Jan Albert and Kastelein, John J. and Hayden, Michael R.

CROSS SECTIONAL AND LONGITUDINAL 3T MAGNETIC RESONANCE SPECTROSCOPY IN A TRACK-HD COHORT OF INDIVIDUALS WITH PREMANIFEST AND EARLY HUNTINGTON'S DISEASE

Journal of Neurology Neurosurgery and Psychiatry

Sturrock, A. and Laule, C. and Decolongon, J. and Santos, R. D. and Coleman, A. J. and Creighton, S. and Bechtel, N. and Reilmann, R. and Hayden, M. R. and Tabrizi, S. J. and Mackay, A. L. and Leavitt, B. R.

Cholesterol in -cell dysfunction: The emerging connection between HDL cholesterol and type 2 diabetes

Current Diabetes Reports

Brunham, L.R. and Kruit, J.K. and Hayden, M.R. and Verchere, C.B.

Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes

Journal of Neuroscience

Valenza, M. and Leoni, V. and Karasinska, J.M. and Petricca, L. and Fan, J. and Carroll, J. and Pouladi, M.A. and Fossale, E. and Nguyen, H.P. and Riess, O. and MacDonald, M. and Wellington, C. and DiDonato, S. and Hayden, M. and Cattaneo, E.

The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone

Peptides

Glier, M.B. and Pissios, P. and Babich, S.L. and Macdonald, M.L.E. and Hayden, M.R. and Maratos-Flier, E. and Gibson, W.T.

Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism

Journal of Biological Chemistry

Chung, S. and Timmins, J.M. and Duong, M. and Degirolamo, C. and Rong, S. and Sawyer, J.K. and Singaraja, R.R. and Hayden, M.R. and Maeda, N. and Rudel, L.L. and Shelness, G.S. and Parks, J.S.

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

Neurobiology of Disease

Huang, K. and Kang, M.H. and Askew, C. and Kang, R. and Sanders, S.S. and Wan, J. and Davis, N.G. and Hayden, M.R.

Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis

Atherosclerosis

van Leuven, S.I. and van Wijk, D.F. and Volger, O.L. and de Vries, J.P.P.M. and van der Loos, C.M. and de Kleijn, D.V.P. and Horrevoets, A.J.G. and Tak, P.P. and van der Wal, A.C. and de Boer, O.J. and Pasterkamp, G. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.

Erratum

Trends in Cardiovascular Medicine

Kang, M.H. and Singaraja, R. and Hayden, M.R.

Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis

Neurobiology of Disease

Soneson, C. and Fontes, M. and Zhou, Y. and Denisov, V. and Paulsen, J.S. and Kirik, D. and Petersn, ?. and Paulson, H. and Elbert, M. and Nopoulos, P. and Rodnitzky, R. and Uc, E. and Beglinger, L. and Duff, K. and Magnotta, V.A. and Cross, S. and Doucette, N. and Juhl, A. and Schumacher, J. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E. and Thomsen, T. and Ames, D. and Chiu, E. and Chua, P. and Yastrubetskaya, O. and Dingjan, P. and Draper, K. and Georgiou-Karistianis, N. and Goh, A. and Komiti, A. and Raymond, L. and Dar Santos, R. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Agarwal, A. and Shpritz, B. and Welsh, C. and Mallonee, W.M. and Suter, G. and Samii, A. and Lipe, H. and Weaver, K. and Jones, R. and Harrison, J. and Ingram, C. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and McCusker, E. and Griffith, J. and Bibb, B. and Richardson, K. and Landwehrmeyer, B.G. and Ecker, D. and Weydt, P. and Orth, M. and S?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Singer, A. and Stober, J. and Perlman, S. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Warner, T. and Kloppel, S. and Burrows, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Naji, J. and Price, K. and Handley, O.J. and Como, P. and Chesire, A. and Marshall, F. and Wodarski, M. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Rosas, D. and Young, A. and Bender, A. and Zaleta, A. and Panegyres, P. and Connor, C. and Vuletich, E. and Woodman, M. and Zombor, R. and Perlmutter, J. and Barton, S. and Simpson, S.A. and Matheson, K. and Ure, A. and Craufurd, D. and Fullam, R. and Macleod, R. and Sollom, A. and Howard, E. and Mazzoni, P. and Marder, K. and Moskowitz, C. and Wasserman, P. and Seeberger, L. and Diamond, A. and Erickson, D. and Miracle, D. and Montellano, S. and Kumar, R. and Wheelock, V. and Tempkin, T. and Marsano, J. and Sanders, M. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and de Yebenes, J.G. and Garde, M.B. and Fatas, M. and Martinez, A. and Nance, M. and Radtke, D. and Tupper, D. and Martin, W. and King, P. and Wieler, M. and Sran, S. and Langbehn, D. and Johnson, H. and Magnotta, V. and Pierson, R. and Williams, J. and Aylward, E. and Biglan, K. and Erwin, C. and Hayden, M. and Leavitt, B. and Macdonald, M. and Rao, S. and Stout, J.C. and Blanchard, S. and Dudler, A. and Henneberry, M. and Montross, K. and O'brien, P. and Mills, J.A. and Wang, C. and Werling-Witkoske, C. and Adams, W. and Anderson, K. and Thompson, S. and Didonato, S. and Mattson, W. and Petersen, A. and Harrington, D. and Westervelt, H. and Moser, D. and Smith, M. and Campbell, C. and Davison, J. and Queller, S. and Clark, L.A. and Leserman, A. and O'rourke, J. and Brossman, B. and Ro, E. and Ready, R. and Vaccarino, A. and Farias, S. and Carlozzi, N. and Nehl, C. and Gusella, J. and Myers, R. and Wassink, T. and Potkin, S. and Toga, A. and Beg, M.F. and Miller, M. and Reading, S. and Axelson, E. and Bockholt, J. and Vitense, K. and Helmer, K. and Lim, K. and Mori, S. and Song, A. and Turner, J. and Beall, E. and Koenig, K. and Lowe, M. and Phillips, M. and Reece, C. and Zimbelman, J. and Anderson, K. and Fedorowicz, J. and Robinson, R. and van Duijn, E. and Oakes, D. and Bourgeois, K. and Whitlock, K. and Vik, S. and Anderson, C. and Schumaker, J. and Reynolds, N. and Coryell, W. and Smith, J. and Connell, R.J. and Weber, J. and Werling, C. and Kayson, E. and Julian-Baros, E. and Covert, C. and Daigneault, S. and Meyers, K. and Rothenburgh, K. and Olsen, B. and Orme, C. and Ross, T. and Simone, M. and Zhao, H. and Johnson, S.A. and Colin Campbell, J. and Peters, E. and Carlozzi, N.E. and Green, T. and Swain, S.N. and Caughlin, D. and Ward-Bluhm, B. and Trautman, S. and Hersch, S.

A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans

Human Molecular Genetics

Acua-Alonzo, V. and Flores-Dorantes, T. and Kruit, J.K. and Villarreal-Molina, T. and Arellano-Campos, O. and Hnemeier, T. and Moreno-Estrada, A. and Ortiz-Lpez, M.G. and Villamil-Ramrez, H. and Len-Mimila, P. and Villalobos-Comparan, M. and Jacobo-Albavera, L. and Ramrez-Jimnez, S. and Sikora, M. and Zhang, L.-H. and Pape, T.D. and de ?ngeles Granados-Silvestre, M. and Montufar-Robles, I. and Tito-Alvarez, A.M. and Zurita-Salinas, C. and Bustos-Arriaga, J. and Cedillo-Barrn, L. and Gmez-Trejo, C. and Barquera-Lozano, R. and Vieira-Filho, J.P. and Granados, J. and Romero-Hidalgo, S. and Huertas-Vzquez, A. and Gonzlez-Martn, A. and Gorostiza, A. and Bonatto, S.L. and Rodrguez-Cruz, M. and Wang, L. and Tusi-Luna, T. and Aguilar-Salinas, C.A. and Lisker, R. and Moises, R.S. and Menjivar, M. and Salzano, F.M. and Knowler, W.C. and Bortolini, M.C. and Hayden, M.R. and Baier, L.J. and Canizales-Quinteros, S.

Unstable familial transmissions of huntington disease alleles with 27-35 CAG repeats (intermediate alleles)

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Semaka, A. and Collins, J.A. and Hayden, M.R.

Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease

Neurology

Sturrock, A. and Laule, C. and Decolongon, J. and Dar Santos, R. and Coleman, A.J. and Creighton, S. and Bechtel, N. and Reilmann, R. and Hayden, M.R. and Tabrizi, S.J. and MacKay, A.L. and Leavitt, B.R.

Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia

Experimental Biology and Medicine

Ding, Y.-L. and Wang, Y.-H. and Huang, W. and Liu, G. and Ross, C. and Hayden, M.R. and Yang, J.-K.

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo

Journal of Neuroscience

Graham, R.K. and Deng, Y. and Carroll, J. and Vaid, K. and Cowan, C. and Pouladi, M.A. and Metzler, M. and Bissada, N. and Wang, L. and Faull, R.L.M. and Gray, M. and Yang, X.W. and Raymond, L.A. and Hayden, M.R.

TREATMENT WITH ARIMOCLOMOL DOES NOT LEAD TO RESCUE OF MOTOR OR STRIATAL DEFICITS IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE

Journal of Neurology Neurosurgery and Psychiatry

Pouladi, M. A. and Carroll, J. and Santos, R. D. and Bertram, L. and Hayden, M. R.

Application of principal component analysis to pharmacogenomic studies in Canada

Pharmacogenomics Journal

Visscher, H. and Ross, C.J.D. and Dub, M.-P. and Brown, A.M.K. and Phillips, M.S. and Carleton, B.C. and Hayden, M.R.

Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels

Journal of Lipid Research

Vaessen, S.F.C. and Dallinga-Thie, G.M. and Ross, C.J.D. and Splint, L.J. and Castellani, L.W. and Rensen, P.C.N. and Hayden, M.R. and Schaap, F.G. and Kuivenhoven, J.A.

Adverse drug reaction active surveillance: Developing a national network in Canada's children's hospitals

Pharmacoepidemiology and Drug Safety

Carleton, B.C. and Poole, R.L. and Smith, M.A. and Leeder, J.S. and Ghannadan, R. and Ross, C.J.D. and Phillips, M.S. and Hayden, M.R.

Response to Falush: A Role for cis-Element Polymorphisms in HD

American Journal of Human Genetics

Warby, S.C. and Visscher, H. and Butland, S. and Pearson, C.E. and Hayden, M.R.

Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study

Clinical Pharmacology and Therapeutics

Madadi, P. and Ross, C.J.D. and Hayden, M.R. and Carleton, B.C. and Gaedigk, A. and Leeder, J.S. and Koren, G.

Palmitoylation of ATP-binding cassette transporter A1 Is essential for its trafficking and function

Circulation Research

Singaraja, R.R. and Kang, M.H. and Vaid, K. and Sanders, S.S. and Vilas, G.L. and Arstikaitis, P. and Coutinho, J. and Drisdel, R.C. and El Din El-Husseini, A. and Green, W.N. and Berthiaume, L. and Hayden, M.R.

Genotypic Approaches to Therapy in Children (GATC): Using information technology to improve drug safety

Studies in Health Technology and Informatics

Wong, E. and Carleton, B.C. and Wright, D.F.B. and Smith, M.A. and Verbeek, L. and Hildebrand, C.A. and Stannard, P. and Vaillancourt, R. and Elliot-Miller, P. and Ross, C.J.D. and Hayden, M.R.

Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice

Biochemical and Biophysical Research Communications

Xian, X. and Ding, Y. and Zhang, L. and Wang, Y. and McNutt, M.A. and Ross, C. and Hayden, M.R. and Deng, X. and Liu, G.

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

Nature Medicine

Okamoto, S.-I. and Pouladi, M.A. and Talantova, M. and Yao, D. and Xia, P. and Ehrnhoefer, D.E. and Zaidi, R. and Clemente, A. and Kaul, M. and Graham, R.K. and Zhang, D. and Vincent Chen, H.-S. and Tong, G. and Hayden, M.R. and Lipton, S.A.

The role of free fatty acids, pancreatic lipase and Ca2+ signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice

Acta Physiologica

Yang, F. and Wang, Y. and Sternfeld, L. and Rodriguez, J.A. and Ross, C. and Hayden, M.R. and Carriere, F. and Liu, G. and Schulz, I.

Tetrabenazine

Nature Reviews Drug Discovery

Hayden, M.R. and Leavitt, B.R. and Yasothan, U. and Kirkpatrick, P.

Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease

Journal of Neuroscience

Fan, J. and Cowan, C.M. and Zhang, L.Y.J. and Hayden, M.R. and Raymond, L.A.

Differential susceptibility to excitotoxic stress in YAC128 mouse models of huntington disease between initiation and progression of disease

Journal of Neuroscience

Graham, R.K. and Pouladi, M.A. and Joshi, P. and Lu, G. and Deng, Y. and Wu, N.-P. and Figueroa, B.E. and Metzler, M. and Andr, V.M. and Slow, E.J. and Raymond, L. and Friedlander, R. and Levine, M.S. and Leavitt, B.R. and Hayden, M.R.

Acute hypertriglyceridemic pancreatitis during pregnancy due to homozygous lipoprotein lipase gene mutation

Clinica Chimica Acta

Bartha, I. and Dinya, T. and Seres, I. and Paragh, G. and Ross, C. and Hayden, M.R. and Bir, S. and Vargha, G.

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

Molecular and Cellular Neuroscience

Warby, S.C. and Doty, C.N. and Graham, R.K. and Shively, J. and Singaraja, R.R. and Hayden, M.R.

Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

MacDonald, M.L.E. and Bissada, N. and Vallance, B.A. and Hayden, M.R.

Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

MacDonald, M.L.E. and Van Eck, M. and Hildebrand, R.B. and Wong, B.W.C. and Bissada, N. and Ruddle, P. and Kontush, A. and Hussein, H. and Pouladi, M.A. and Chapman, M.J. and Fievet, C. and Van Berkel, T.J.C. and Staels, B. and McManus, B.M. and Hayden, M.R.

Mouse models of Huntington disease: Variations on a theme

DMM Disease Models and Mechanisms

Ehrnhoefer, D.E. and Butland, S.L. and Pouladi, M.A. and Hayden, M.R.

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Journal of Cell Biology

Thompson, L.M. and Aiken, C.T. and Kaltenbach, L.S. and Agrawal, N. and Illes, K. and Khoshnan, A. and Martinez-Vincente, M. and Arrasate, M. and O'Rourke, J.G. and Khashwji, H. and Lukacsovich, T. and Zhu, Y.-Z. and Lau, A.L. and Massey, A. and Hayden, M.R. and Zeitlin, S.O. and Finkbeiner, S. and Green, K.N. and LaFerla, F.M. and Bates, G. and Huang, L. and Patterson, P.H. and Lo, D.C. and Cuervo, A.M. and Marsh, J.L. and Steffan, J.S.

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenesinfection

Proceedings of the National Academy of Sciences of the United States of America

Yeretssian, G. and Doiron, K. and Shao, W. and Leavitt, B.R. and Hayden, M.R. and Nicholson, D.W. and Saleh, M.

Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function

Journal of Neuroscience

Karasinska, J.M. and Rinninger, F. and Ltjohann, D. and Ruddle, P. and Franciosi, S. and Kruit, J.K. and Singaraja, R.R. and Hirsch-Reinshagen, V. and Fan, J. and Brunham, L.R. and Bissada, N. and Ramakrishnan, R. and Wellington, C.L. and Parks, J.S. and Hayden, M.R.

Presynaptic defects impair learning and memory function in lipoprotein lipase deficient mice

Journal of Neurochemistry

Yu, J. and Liu, T. T. and Xian, X. D. and Wang, Y. H. and Miao, Y. F. and Zhang, J. J. and Yu, Y. and Ross, C. and Hayden, M. R. and Liu, G. and Chui, D. H.

Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells

Gut

Wang, Y. and Sternfeld, L. and Yang, F. and Rodriguez, J.A. and Ross, C. and Hayden, M.R. and Carriere, F. and Liu, G. and Hofer, W. and Schulz, I.

CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup

American Journal of Human Genetics

Warby, S.C. and Montpetit, A. and Hayden, A.R. and Carroll, J.B. and Butland, S.L. and Visscher, H. and Collins, J.A. and Semaka, A. and Hudson, T.J. and Hayden, M.R.

Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of huntington disease

Journal of Neuroscience

Joshi, P.R. and Wu, N.-P. and Andr, V.M. and Cummings, D.M. and Cepeda, C. and Joyce, J.A. and Carroll, J.B. and Leavitt, B.R. and Hayden, M.R. and Levine, M.S. and Bamford, N.S.

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Brunham, L.R. and Singaraja, R.R. and Duong, M. and Timmins, J.M. and Fievet, C. and Bissada, N. and Kang, M.H. and Samra, A. and Fruchart, J.-C. and McManus, B. and Staels, B. and Parks, J.S. and Hayden, M.R.

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin

Brain

Pouladi, M.A. and Graham, R.K. and Karasinska, J.M. and Xie, Y. and Santos, R.D. and Petersn, . and Hayden, M.R.

Presynaptic defects underlying impaired learning and memory function in lipoprotein Lipase-deficient mice

Journal of Neuroscience

Xian, X. and Liu, T. and Yu, J. and Wang, Y. and Miao, Y. and Zhang, J. and Yu, Y. and Ross, C. and Karasinska, J.M. and Hayden, M.R. and Liu, G. and Chui, D.

Perceptions of genetic discrimination among people at risk for Huntingtons disease: A cross sectional survey

BMJ (Online)

Bombard, Y. and Veenstra, G. and Friedman, J.M. and Creighton, S. and Currie, L. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R. and Guttman, M. and Giambattista, C. and Ludman, M. and Murphy, J. and Babineau-Sturk, T. and Macleod, P. and Rice, J. and Martin, W. and Wieler, M. and Meschino, W. and Gibbons, C. and Raymond, L. and Decolongon, J. and Suchowersky, O. and Klimek, M.-L.

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity

FASEB Journal

Huang, K. and Sanders, S. and Singaraja, R. and Orban, P. and Cijsouw, T. and Arstikaitis, P. and Yanai, A. and Hayden, M.R. and El-Husseini, A.

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells

Journal of Biological Chemistry

Ratovitski, T. and Gucek, M. and Jiang, H. and Chighladze, E. and Waldron, E. and D'Ambola, J. and Zhipeng, H. and Yideng, L. and Poirier, M.A. and Hirschhorn, R.R. and Graham, R. and Hayden, M.R. and Cole, R.N. and Ross, C.A.

Motor abnormalities in premanifest persons with Huntington's disease: The PREDICT-HD study

Movement Disorders

Biglan, K.M. and Ross, C.A. and Langbehn, D.R. and Aylward, E.H. and Stout, J.C. and Queller, S. and Carlozzi, N.E. and Duff, K. and Beglinger, L.J. and Paulsen, J.S. and Johnson, H. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Guttman, M. and Hayden, M. and Landwehrmeyer, B.G. and Nance, M.

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

Nature Genetics

Ross, C.J.D. and Katzov-Eckert, H. and Dub, M.-P. and Brooks, B. and Rassekh, S.R. and Barhdadi, A. and Feroz-Zada, Y. and Visscher, H. and Brown, A.M.K. and Rieder, M.J. and Rogers, P.C. and Phillips, M.S. and Carleton, B.C. and Hayden, M.R.

Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease

NeuroImage

Lerch, J.P. and Carroll, J.B. and Dorr, A. and Spring, S. and Evans, A.C. and Hayden, M.R. and Sled, J.G. and Henkelman, R.M.

Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: Impact on NMDA receptor function and toxicity

Journal of Neuroscience

Cowan, C.M. and Fan, M.M.Y. and Fan, J. and Shehadeh, J. and Zhang, L.Y.J. and Graham, R.K. and Hayden, M.R. and Raymond, L.A.

A toxicogenetic case-control study of codeine toxicity during breastfeeding

Clinical Pharmacology & Therapeutics

Madadi, P. and Ross, C. J. and Pape, T. and Gaedigk, A. and Carleton, B. C. and Hayden, M. R. and Leeder, S. J. and Korens, G.

A humanized BAC transgenic/knockout mouse model for human caspase-12 polymorphism

Cytokine

Yeretssian, Garabet and Hayden, Michael R. and Nicholson, Donald W. and Saleh, Maya

Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet

Circulation Research

Zhang, X. and Qi, R. and Xian, X. and Yang, F. and Blackstein, M. and Deng, X. and Fan, J. and Ross, C. and Karasinska, J. and Hayden, M.R. and Liu, G.

Intramuscular administration of AAV1-lipoprotein lipaseS447X lowers triglycerides in lipoprotein lipase-deficient patients

Arteriosclerosis Thrombosis and Vascular Biology

Stroes, E.S. and Nierman, M.C. and Meulenberg, J.J. and Franssen, R. and Twisk, J. and Henny, C.P. and Maas, M.M. and Zwinderman, A.H. and Ross, C. and Aronica, E. and High, K.A. and Levi, M.M. and Hayden, M.R. and Kastelein, J.J. and Kuivenhoven, J.A.

Intermediate alleles for Huntington's disease: Patient understanding and current genetic counselling practices

Journal of Neurology Neurosurgery and Psychiatry

Semaka, A. and Balneaves, L. and Hayden, M. R.

Cholesterol in islet dysfunction and type 2 diabetes

Journal of Clinical Investigation

Brunham, L.R. and Kruit, J.K. and Verchere, C.B. and Hayden, M.R.

Automated deformation analysis in the YAC128 Huntington disease mouse model

NeuroImage

Lerch, J.P. and Carroll, J.B. and Spring, S. and Bertram, L.N. and Schwab, C. and Hayden, M.R. and Mark Henkelman, R.

Activation of caspase-6 is an early event in acute and chronic models of Huntington's disease

Journal of Neurology Neurosurgery and Psychiatry

Graham, R. K. and Deng, Y. and Vaid, K. and Bissada, N. and Murphy, Z. and Wang, L. and Hayden, M. R.

Caspases-2 and 6 as drug targets in Huntington's disease

Journal of Neurology Neurosurgery and Psychiatry

Carroll, J. B. and Ehrnhoefer, D. E. and Graham, R. K. and Cao, L-P and Hayden, M. R.

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

Human Molecular Genetics

Warby, S.C. and Doty, C.N. and Graham, R.K. and Carroll, J.B. and Yang, Y.-Z. and Singaraja, R.R. and Overall, C.M. and Hayden, M.R.

Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice

Journal of Lipid Research

MacDonald, M.L.E. and Singaraja, R.R. and Bissada, N. and Ruddle, P. and Watts, R. and Karasinska, J.M. and Gibson, W.T. and Fievet, C. and Vance, J.E. and Staels, B. and Hayden, M.R.

Engagement with genetic discrimination: Concerns and experiences in the context of Huntington disease

European Journal of Human Genetics

Bombard, Y. and Penziner, E. and Suchowersky, O. and Guttman, M. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R.

Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic Beta Cell Dysfunction

Circulation

Vergeer, Menno and Brunham, Liam R. and Koetsveld, Joris and Kruit, Janine K. and Verchere, C. B. and Kastelein, John J. and Hayden, Michael R. and Stroes, Erik S.

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

Human Molecular Genetics

Wang, C.-E. and Tydlacka, S. and Orr, A.L. and Yang, S.-H. and Graham, R.K. and Hayden, M.R. and Li, S. and Chan, A.W.S. and Li, X.-J.

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

Neurobiology of Disease

Zhang, H. and Li, Q. and Graham, R.K. and Slow, E. and Hayden, M.R. and Bezprozvanny, I.

Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors

Journal of Neurochemistry

Fan, M.M.Y. and Zhang, H. and Hayden, M.R. and Pelech, S.L. and Raymond, L.A.

Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Penziner, E. and Williams, J.K. and Erwin, C. and Bombard, Y. and Wallis, A. and Beglinger, L.J. and Hayden, M.R. and Paulsen, J.S.

ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease

JAMA - Journal of the American Medical Association

Brunham, L.R. and Kastelein, J.J.P. and Hayden, M.R.

Response to the letter by Ebara et al

Circulation Research

Liu, G. and Hayden, M.R.

Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats

Movement Disorders

Semaka, A. and Warby, S. and Leavitt, B.R. and Hayden, M.R.

A toxicogenetic case-control study of codeine toxicity during breastfeeding.

Clinical Pharmacology & Therapeutics

Madadi, P. and Ross, C. J. and Pape, T. and Gaedigk, A. and Carleton, B. C. and Hayden, M. R. and Leeder, S. J. and Korens, G.

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Journal of Experimental Medicine

Bjrkqvist, M. and Wild, E.J. and Thiele, J. and Silvestroni, A. and Andre, R. and Lahiri, N. and Raibon, E. and Lee, R.V. and Benn, C.L. and Soulet, D. and Magnusson, A. and Woodman, B. and Landles, C. and Pouladi, M.A. and Hayden, M.R. and Khalili-Shirazi, A. and Lowdell, M.W. and Brundin, P. and Bates, G.P. and Leavitt, B.R. and Mller, T. and Tabrizi, S.J.

Mechanisms of altered N-methyl-D-aspartate receptor-mediated calcium signaling in the YAC mouse model of Huntington's disease

Journal of General Physiology

Milnerwood, A. and Gladding, C. and Hayden, M. R. and Murphy, T. H. and Raymond, L. A.

Detection of Huntington's disease decades before diagnosis: The Predict-HD study

Journal of Neurology, Neurosurgery and Psychiatry

Paulsen, J.S. and Langbehn, D.R. and Stout, J.C. and Aylward, E. and Ross, C.A. and Nance, M. and Guttman, M. and Johnson, S. and MacDonald, M. and Beglinger, L.J. and Duff, K. and Kayson, E. and Biglan, K. and Shoulson, I. and Oakes, D. and Hayden, M.

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation

Human Molecular Genetics

Valenza, M. and Carroll, J.B. and Leoni, V. and Bertram, L.N. and Bjrkhem, I. and Singaraja, R.R. and Di Donato, S. and Lutjohann, D. and Hayden, M.R. and Cattaneo, E.

-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

Nature Medicine

Brunham, L.R. and Kruit, J.K. and Pape, T.D. and Timmins, J.M. and Reuwer, A.Q. and Vasanji, Z. and Marsh, B.J. and Rodrigues, B. and Johnson, J.D. and Parks, J.S. and Verchere, C.B. and Hayden, M.R.

The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset

Annals of Human Genetics

Andresen, J.M. and Gayn, J. and Djouss, L. and Roberts, S. and Brocklebank, D. and Cherny, S.S. and Cardon, L.R. and Gusella, J.F. and Macdonald, M.E. and Myers, R.H. and Housman, D.E. and Wexler, N.S. and Lorimer, J. and Porter, J. and Gomez, F. and Moskowitz, C. and Gerstenhaber, K.P. and Shackell, E. and Marder, K. and Penchaszadeh, G. and Roberts, S.A. and Brickman, A. and Brocklebank, D. and Gray, J. and Dlouhy, S.R. and Wiktorski, S. and Hodes, M.E. and Conneally, P.M. and Penney, J.B. and Gusella, J.F. and Cha, J.-H. and Irizarry, M. and Rosas, D. and Hersch, S. and Hollingsworth, Z. and Young, A.B. and Housman, D.E. and de Young, M.M. and Bonilla, E. and Stillings, T. and Negrette, A. and Snodgrass, S.R. and Martinez-Jaurrieta, M.D. and Ramos-Arroyoh, M.A. and Bickham, J. and Ramos, J.S. and Marshall, F. and Shoulson, I. and Rey, G.J. and Feigin, A. and Arnheim, N. and Acevedo-Cruz, A. and Acosta, L. and Alvir, J. and Fischbeck, K. and Thompson, L.M. and Young, A. and Dure, L. and O'Brien, C.J. and Paulsen, J. and Moran, S.P. and Krch, D. and Hogarth, P. and Higgins Jr., D.S. and Landwehrmeyer, B. and Hayden, M.R. and Almqvist, E.W. and Brinkman, R.R. and Suchowersky, O. and Durr, A. and Dod, C.Catherine and Squitieri, F. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Estrella, G.-T. and Cabrero, D.M. and Trent, R.J.A. and McCusker, E. and Novelletto, A. and Frontali, M. and Paulsen, J.S. and Jones, R. and Zanko, A. and Ashizawa, T. and Lazzarini, A. and Li, J.-L. and Wheeler, V.C. and Russ, A.L. and Xu, G. and Mysore, J.S. and Gillis, T. and Hakky, M. and Cupples, L.A. and Saint-Hilaire, M. and Hersch, S.M.

Predictors of diagnosis in Huntington disease

Neurology

Langbehn, D.R. and Paulsen, J.S. and Hedges, P. and McCusker, E. and Pearce, S. and Trent, R. and Abwender, D. and Como, P. and Gardiner, I. and Hickey, C. and Kayson, E. and Kieburtz, K. and Marshall, F. and Pearson, N. and Shoulson, I. and Zimmerman, C. and Louis, E. and Marder, K. and Moskowitz, C. and Polanco, C. and Taylor, S. and Zubin, N. and Brown, C. and Burke-Holder, J. and Guttman, M. and Russell, S. and Stewart, D. and Thomson, J. and Sax, D.S. and Saint-Hilaire, M. and Gray, J. and Hunter, C. and Mercado, N. and Siemers, E. and Wojcieszek, J. and Dawson, T. and Leritz, E. and Rosenblatt, A. and Sherr, M. and Young, C. and Ashizawa, T. and Beach, J. and Jankovic, J. and Jaglin, J. and Shannon, K. and Lundin, A. and Francis, K. and Lane, K. and Auchus, A. and Greenamyre, J.T. and Hersch, S. and Jones, R. and Olson, D. and Cha, J.-H.J. and Cudkowicz, M. and Koroshetz, W. and Rudolf, G. and Sexton, P. and Young, A.B. and Albin, R. and Wernette, K. and Higgins, D.S. and Reider, C. and Hunt, V. and Walker, F. and Hauser, R. and Sanchez-Ramos, J. and Walker, A. and Nance, M. and Cleary, S. and Rohs, G. and Suchowersky, O. and Duncan, K. and Seeberger, L. and Corey-Bloom, J. and Swenson, M. and Swerdlow, N. and Paulson, H. and Rodnitzky, R. and Vining, L. and Martin, W. and Wieler, M. and Facca, A. and Rey, G. and Weiner, W. and Adler, C. and Caviness, J. and Lied, C. and Newman, S. and Feigin, A. and Mazurkiewicz, J. and Caplan, K. and Cellar, J. and Marek, K. and Hayden, M. and Raymond, L. and Dure, L.S. and Lane, J. and Brown, D. and Factor, S. and Molho, E. and Harrison, M. and Manning, C. and Rost-Ruffner, E. and Adams, J. and Cummings, R. and Wheelock, V. and Dubinsky, R. and Gray, C. and Catherine Bachoud-Levi, A. and Meierkord, H. and Friedman, J. and Lannon, M. and Lawrence, J. and Rubin, A. and Schwarz, R. and Brocht, A. and Claude, K. and Goldstein, J. and McDermott, M. and Oakes, D.

Evaluation of recombinant AAV1 produced in insect cells for muscle-directed gene transfer

Human Gene Therapy

Twisk, Jaap and Ross, Colin J. D. and Comijn, Lizzy and Biesmans, Dennis and Haast, Saskia and Bakker, Andrew C. and Van Amersfoort, Edwin S. and Van Deventer, Sander J. H. and Meulenberg, Janneke J. M. and Hayden, Michael R. and Hermens, Wim T.

Beyond disgust: Impaired recognition of negative emotions prior to diagnosis in Huntington's disease

Brain

Johnson, S.A. and Stout, J.C. and Solomon, A.C. and Langbehn, D.R. and Aylward, E.H. and Cruce, C.B. and Ross, C.A. and Nance, M. and Kayson, E. and Julian-Baros, E. and Hayden, M.R. and Kieburtz, K. and Guttman, M. and Oakes, D. and Shoulson, I. and Beglinger, L. and Duff, K. and Penziner, E. and Paulsen, J.S.

When good drugs go bad

Nature

Giacomini, K.M. and Krauss, R.M. and Roden, D.M. and Eichelbaum, M. and Hayden, M.R. and Nakamura, Y.

Testicular degeneration in Huntington disease

Neurobiology of Disease

Van Raamsdonk, J.M. and Murphy, Z. and Selva, D.M. and Hamidizadeh, R. and Pearson, J. and Petersn, ?. and Bjrkqvist, M. and Muir, C. and Mackenzie, I.R. and Hammond, G.L. and Vogl, A.W. and Hayden, M.R. and Leavitt, B.R.

Spontanous atherosclerosis in old LPL-Deficient mice with severe hypertriglyceridemia on a normal chow diet

Arteriosclerosis Thrombosis and Vascular Biology

Zhang, Xiaohong and Qi, Rong and Xian, Xunde and Huang, Wei and Fan, Jianglin and Ross, Colin and Hayden, Michael R. and Liu, George

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid- peptide levels in vivo

Journal of Lipid Research

Hirsch-Reinshagen, V. and Chan, J.Y. and Wilkinson, A. and Tanaka, T. and Fan, J. and Ou, G. and Maia, L.F. and Singaraja, R.R. and Hayden, M.R. and Wellington, C.L.

Pharmacogenomics and its implications for autoimmune disease

Journal of Autoimmunity

Ross, C.J.D. and Katzov, H. and Carleton, B. and Hayden, M.R.

Lessons learned on the design of a pharmacogenomic study

Pharmacoepidemiology and Drug Safety

Dube, Marie-Pierre and Aeschliman, Dana S. and Carleton, Bruce C. and Hayden, Michael R.

Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Wang, J. and Xian, X. and Huang, W. and Chen, L. and Wu, L. and Zhu, Y. and Fan, J. and Ross, C. and Hayden, M.R. and Liu, G.

Canadian national active surveillance network for adverse drug reactions: Genotypic approaches to therapy in children (GATC): The first year

Pharmacoepidemiology and Drug Safety

Carleton, B. C. and Warn, D. and Stenton, S. and Rassekh, R. and Smith, M. A. and Dhami, B. and Ross, C. and Hayden, M. R.

Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1-/- mice

Molecular Reproduction and Development

Khatchadourian, K. and Smith, C.E. and Metzler, M. and Gregory, M. and Hayden, M.R. and Cyr, D.G. and Hermo, L.

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

Neurobiology of Disease

Van Raamsdonk, J.M. and Metzler, M. and Slow, E. and Pearson, J. and Schwab, C. and Carroll, J. and Graham, R.K. and Leavitt, B.R. and Hayden, M.R.

Mycophenolate mofetil and atherosclerosis: Results of animal and human studies

Annals of the New York Academy of Sciences

Gibson, W.T. and Hayden, M.R.

Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease

Neuroscience

Benn, C.L. and Slow, E.J. and Farrell, L.A. and Graham, R. and Deng, Y. and Hayden, M.R. and Cha, J.-H.J.

Chapter 15 Juvenile amyotrophic lateral sclerosis

Handbook of Clinical Neurology

Orban, P. and Devon, R.S. and Hayden, M.R. and Leavitt, B.R.

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease

Journal of Neuroscience

Fan, M.M.Y. and Fernandes, H.B. and Zhang, L.Y.J. and Hayden, M.R. and Raymond, L.A.

Selective degeneration in YAC mouse models of Huntington disease

Brain Research Bulletin

Van Raamsdonk, J.M. and Warby, S.C. and Hayden, M.R.

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease

Journal of Neuroscience

Fernandes, H.B. and Baimbridge, K.G. and Church, J. and Hayden, M.R. and Raymond, L.A.

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

Clinical Genetics

Goldberg, Y.P. and Macfarlane, J. and Macdonald, M.L. and Thompson, J. and Dube, M.P. and Mattice, M. and Fraser, R. and Young, C. and Hossain, S. and Pape, T. and Payne, B. and Radomski, C. and Donaldson, G. and Ives, E. and Cox, J. and Younghusband, H.B. and Green, R. and Duff, A. and Boltshauser, E. and Grinspan, G.A. and Dimon, J.H. and Sibley, B.G. and Andria, G. and Toscano, E. and Kerdraon, J. and Bowsher, D. and Pimstone, S.N. and Samuels, M.E. and Sherrington, R. and Hayden, M.R.

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease

Cell Cycle

Ratovitski, T. and Nakamura, M. and D'Ambola, J. and Chighladze, E. and Liang, Y. and Wang, W. and Graham, R. and Hayden, M.R. and Borchelt, D.R. and Hirschhorn, R.R. and Ross, C.A.

Erratum: Predictive testing for Huntington disease: Interpretation and significance of intermediate alleles (Clinical Genetics (2006) vol. 70 (283-294))

Clinical Genetics

Semaka, A. and Creighton, S. and Warby, S. and Hayden, M.R.

CAG-encoded polyglutamine length polymorphism in the human genome

BMC Genomics

Butland, S.L. and Devon, R.S. and Huang, Y. and Mead, C.-L. and Meynert, A.M. and Neal, S.J. and Lee, S.S. and Wilkinson, A. and Yang, G.S. and Yuen, M.M.S. and Hayden, M.R. and Holt, R.A. and Leavitt, B.R. and Ouellete, B.F.F.

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Human Molecular Genetics

Kuhn, A. and Goldstein, D.R. and Hodges, A. and Strand, A.D. and Sengstag, T. and Kooperberg, C. and Becanovic, K. and Pouladi, M.A. and Sathasivam, K. and Cha, J.-H.J. and Hannan, A.J. and Hayden, M.R. and Leavitt, B.R. and Dunnett, S.B. and Ferrante, R.J. and Albin, R. and Shelbourne, P. and Delorenzi, M. and Augood, S.J. and Faull, R.L.M. and Olson, J.M. and Bates, G.P. and Jones, L. and Luthi-Carter, R.

Verbal episodic memory declines prior to diagnosis in Huntington's disease

Neuropsychologia

Solomon, A.C. and Stout, J.C. and Johnson, S.A. and Langbehn, D.R. and Aylward, E.H. and Brandt, J. and Ross, C.A. and Beglinger, L. and Hayden, M.R. and Kieburtz, K. and Kayson, E. and Julian-Baros, E. and Duff, K. and Guttman, M. and Nance, M. and Oakes, D. and Shoulson, I. and Penziner, E. and Paulsen, J.S.

Predictive testing for Huntington disease: interpretation and significance of intermediate alleles. (vol 70, pg 283, 2006)

Clinical Genetics

Semaka, A. and Creighton, S. and Warby, S. and Hayden, M. R.

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1

Journal of Neuroscience

Metzler, M. and Gan, L. and Tak, P.W. and Liu, L. and Helm, J. and Liu, L. and Georgiou, J. and Wang, Y. and Bissada, N. and Cheng, K. and Roder, J.C. and Yu, T.W. and Hayden, M.R.

Managing genetic discrimination: Strategies used by individuals found to have the Huntington disease mutation

Clinical Genetics

Bombard, Y. and Penziner, B. and Decolongon, J. and Klimek, M.L.N. and Creighton, S. and Suchowersky, O. and Guttman, M. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R.

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity

Journal of Neuroscience

Parker, J.A. and Metzler, M. and Georgiou, J. and Mage, M. and Roder, J.C. and Rose, A.M. and Hayden, M.R. and Nri, C.

Genotypic approaches to therapy in children: A national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children

Annals of the New York Academy of Sciences

Ross, C.J.D. and Carleton, B. and Warn, D.G. and Stenton, S.B. and Rassekh, S.R. and Hayden, M.R.

Body weight is modulated by levels of full-length Huntingtin

Human Molecular Genetics

Van Raamsdonk, J.M. and Gibson, W.T. and Pearson, J. and Murphy, Z. and Lu, G. and Leavitt, B.R. and Hayden, M.R.

Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels

Circulation Research

Brunham, L.R. and Kruit, J.K. and Pape, T.D. and Parks, J.S. and Kuipers, F. and Hayden, M.R.

Molecular Pathogenesis of Huntington's Disease: The Role of Excitotoxicity

Genetic Instabilities and Neurological Diseases

Pouladi, M.A. and Bezprozvanny, I. and Raymond, L.A. and Hayden, M.R.

Lipoprotein lipase S447X: A naturally occurring gain-of-function mutation

Arteriosclerosis, Thrombosis, and Vascular Biology

Rip, J. and Nierman, M.C. and Ross, C.J. and Jukema, J.W. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.G. and Kuivenhoven, J.A.

Hippi is essential for node cilia assembly and Sonic hedgehog signaling

Developmental Biology

Houde, C. and Dickinson, R.J. and Houtzager, V.M. and Cullum, R. and Montpetit, R. and Metzler, M. and Simpson, E.M. and Roy, S. and Hayden, M.R. and Hoodless, P.A. and Nicholson, D.W.

Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

Proceedings of the National Academy of Sciences of the United States of America

Devon, R.S. and Orban, P.C. and Gerrow, K. and Barbieri, M.A. and Schwab, C. and Cao, L.P. and Helm, J.R. and Bissada, M. and Cruz-Aguado, R. and Davidson, T.-L. and Witmer, J. and Metzler, M. and Lam, C.K. and Tetzlaff, W. and Simpson, E.M. and McCaffery, J.M. and El-Husseini, A.E. and Leavitt, B.R. and Hayden, M.R.

Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?

Nature Clinical Practice Neurology

Leavitt, B.R. and Hayden, M.R.

Gene therapy with lipoprotein lipase variant S447X - Response

Arteriosclerosis Thrombosis and Vascular Biology

Ross, CJD and Twisk, J and Kuivenhoven, JA and Rip, J and Kastelein, JJ and Hayden, MR

Critical role of ATP-binding cassette transporter a1 (ABCA1) in beta-cell function and glucose homeostasis

Circulation

Brunham, Liam and Pape, Terry and Soukhatcheva, Galina and Verchere, Bruce and Hayden, Michael R.

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo

Circulation

Singaraja, R.R. and Van Eck, M. and Bissada, N. and Zimetti, F. and Collins, H.L. and Hildebrand, R.B. and Hayden, A. and Brunham, L.R. and Kang, M.H. and Fruchart, J.-C. and Van Berkel, T.J.C. and Parks, J.S. and Staels, B. and Rothblat, G.H. and Fivet, C. and Hayden, M.R.

To be or not to be toxic: aggregations in Huntington and Alzheimer disease

Trends in Genetics

Slow, E.J. and Graham, R.K. and Hayden, M.R.

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

Neurobiology of Disease

Graham, R.K. and Slow, E.J. and Deng, Y. and Bissada, N. and Lu, G. and Pearson, J. and Shehadeh, J. and Leavitt, B.R. and Raymond, L.A. and Hayden, M.R.

Both hepatic and extrahepatic ABCA1 are essential for the maintenance of plasma HDL-C levels in vivo

Atherosclerosis Supplements

Singaraja, R. R. and Van Eck, M. and Fievet, C. and Hayden, M. R.

In response [5]

Arteriosclerosis, Thrombosis, and Vascular Biology

Ross, C.J.D. and Twisk, J. and Kuivenhoven, J.A. and Rip, J. and Kastelein, J.J. and Hayden, M.R.

Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: The HD MAPS study

BMC Medical Genetics

Li, J.-L. and Hayden, M.R. and Warby, S.C. and Durr, A. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Squitieri, F. and Frati, L. and Gmez-Tortosa, E. and Garca, C.A. and Suchowersky, O. and Klimek, M.L. and Trent, R.J.A. and McCusker, E. and Novelletto, A. and Frontali, M. and Paulsen, J.S. and Jones, R. and Ashizawa, T. and Lazzarini, A. and Wheeler, V.C. and Prakash, R. and Xu, G. and Djouss, L. and Mysore, J.S. and Gillis, T. and Hakky, M. and Cupples, L.A. and Saint-Hilaire, M.H. and Cha, J.-H.J. and Hersch, S.M. and Penney, J.B. and Harrison, M.B. and Perlman, S.L. and Zanko, A. and Abramson, R.K. and Lechich, A.J. and Duckett, A. and Marder, K. and Conneally, P.M. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A in plasma

Neurobiology of Disease

Burgess, B.L. and McIsaac, S.A. and Naus, K.E. and Chan, J.Y. and Tansley, G.H.K. and Yang, J. and Miao, F. and Ross, C.J.D. and van Eck, M. and Hayden, M.R. and van Nostrand, W. and St. George-Hyslop, P. and Westaway, D. and Wellington, C.L.

Comparative assessment of seminal traits, ovarian responsiveness and in vitro fertilization in 15 domestic cat models of hereditary disease.

Biology of Reproduction

Magarey, Genevieve M. and Bond, Jennifer B. and Bateman, Helen L. and Haskins, Mark E. and Fyfe, John C. and Baker, Henry J. and Hayden, Michael R. and Ross, Colin J. and Lyons, Leslie A. and Swanson, William F.

Hepatic ABCA1 is a key molecule in HDL cholesteryl ester metabolism in mice

Atherosclerosis Supplements

Brundert, M. and Singaraja, R. R. and Stahmer, B. and Parks, J. S. and Hayden, M. R. and Rinninger, F.

Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia

Biochemical and Biophysical Research Communications

Zhao, T. and Guo, J. and Li, H. and Huang, W. and Xian, X. and Ross, C.J.D. and Hayden, M.R. and Wen, Z. and Liu, G.

FASA-57 cDNA shares no homology with coding sequence of HD gene [1]

Journal of Reproductive Immunology

Warby, S. and MacDonald, M. and Butland, S. and Ouellette, F. and Hayden, M.

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

BMC Neuroscience

Van Raamsdonk, J.M. and Pearson, J. and Murphy, Z. and Hayden, M.R. and Leavitt, B.R.

The genotype-phenotype correlation of hereditary multiple exostoses

Clinical Genetics

Alvarez, C. and Tredwell, S. and De Vera, M. and Hayden, M.

Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro

Circulation Research

Singaraja, R.R. and Visscher, H. and James, E.R. and Chroni, A. and Coutinho, J.M. and Brunham, L.R. and Kang, M.H. and Zannis, V.I. and Chimini, G. and Hayden, M.R.

Selective deficiency of hepatic ABCA1 results in increased susceptibility to atherosclerosis

Circulation

Brunham, Liam and Timmins, Jenelle M. and Pape, Terry D. and Duong, MyNgan and Parks, John S. and Hayden, Michael R.

Predictive testing for Huntington disease: Interpretation and significance of intermediate alleles

Clinical Genetics

Semaka, A. and Creighton, S. and Warby, S. and Hayden, M.A.

Palmitoylation of huntingtin by HIP14is essential for its trafficking and function

Nature Neuroscience

Yanai, A. and Huang, K. and Kang, R. and Singaraja, R.R. and Arstikaitis, P. and Gan, L. and Orban, P.C. and Mullard, A. and Cowan, C.M. and Raymond, L.A. and Drisdel, R.C. and Green, W.N. and Ravikumar, B. and Rubinsztein, D.C. and El-Husseini, A. and Hayden, M.R.

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

Journal of Clinical Investigation

Brunham, L.R. and Kruit, J.K. and Iqbal, J. and Fievet, C. and Timmins, J.M. and Pape, T.D. and Coburn, B.A. and Bissada, N. and Staels, B. and Groen, A.K. and Hussain, M.M. and Parks, J.S. and Kuipers, F. and Hayden, M.R.

Huntingtin inhibits caspase-3 activation

EMBO Journal

Zhang, Y. and Leavitt, B.R. and Van Raamsdonk, J.M. and Dragatsis, I. and Goldowitz, D. and MacDonald, M.E. and Hayden, M.R. and Friedlander, R.M.

Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin

Cell

Graham, R.K. and Deng, Y. and Slow, E.J. and Haigh, B. and Bissada, N. and Lu, G. and Pearson, J. and Shehadeh, J. and Bertram, L. and Murphy, Z. and Warby, S.C. and Doty, C.N. and Roy, S. and Wellington, C.L. and Leavitt, B.R. and Raymond, L.A. and Nicholson, D.W. and Hayden, M.R.

Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease [4]

Clinical Genetics

Bjrkqvist, M. and Petersn, ?. and Carroll, J. and Nielsen, J. and Ecker, D. and Mulder, H. and Hayden, M.R. and Landwehrmeyer, B. and Brundin, P. and Leavitt, B.R.

A gene therapy approach to treat human lipoprotein lipase deficiency

Atherosclerosis Supplements

Nierman, M. C. and Stroes, E. S. and Twisk, J. and Rip, J. and Dijkhuizen, P. and Ross, C. J. D. and Bakker, A. C. and Hermens, W. T. and Meulenberg, J. M. and Hayden, M. R. and Kastelein, J. J. P. and Kuivenhoven, J. A.

Testicular degeneration in Huntington's disease

Movement Disorders

Leavitt, B. R. and Van Raamsdonk, J. M. and Murphy, Z. and Vogl, A. and Mackenzie, L. and Petersen, A. and Bjorkqvist, M. and Muir, C. and Hayden, M. R.

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

Neurobiology of Disease

Shehadeh, J. and Fernandes, H.B. and Zeron Mullins, M.M. and Graham, R.K. and Leavitt, B.R. and Hayden, M.R. and Raymond, L.A.

Mycophenolate mofetil and animal models

Lupus

Gibson, W.T. and Hayden, M.R.

Mycophenolate mofetil (MMF): Firing at the atherosclerotic plaque from different angles?

Cardiovascular Research

Van Leuven, S.I. and Kastelein, J.J.P. and Allison, A.C. and Hayden, M.R. and Stroes, E.S.G.

Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH

Proceedings of the National Academy of Sciences of the United States of America

Bae, B.-I. and Hara, M.R. and Cascio, M.B. and Wellington, C.L. and Hayden, M.R. and Ross, C.A. and Ha, H.C. and Li, X.-J. and Snyder, S.H. and Sawa, A.

Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Singaraja, R.R. and Stahmer, B. and Brundert, M. and Merkel, M. and Heeren, J. and Bissada, N. and Kang, M. and Timmins, J.M. and Ramakrishnan, R. and Parks, J.S. and Hayden, M.R. and Rinninger, F.

Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation

Human Gene Therapy

Ross, C.J.D. and Twisk, J. and Bakker, A.C. and Miao, F. and Verbart, D. and Rip, J. and Godbey, T. and Dijkhuizen, P. and Hermens, W.T.J.M.C. and Kastelein, J.J.P. and Kuivenhoven, J.A. and Meulenberg, J.M. and Hayden, M.R.

Wild-type huntingtin protects neurons from excitotoxicity

Journal of Neurochemistry

Leavitt, B.R. and Van Raamsdonk, J.M. and Shehadeh, J. and Fernandes, H. and Murphy, Z. and Graham, R.K. and Wellington, C.L. and Raymond, L.A. and Hayden, M.R.

Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.

Annual review of nutrition

Brunham, L.R. and Singaraja, R.R. and Hayden, M.R.

Preparing for preventive clinical trials: The predict-HD study

Archives of Neurology

Paulsen, J.S. and Hayden, M. and Stout, J.C. and Langbehn, D.R. and Aylward, E. and Ross, C.A. and Guttman, M. and Nance, M. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Kayson, E. and Johnson, S. and Penziner, E.

Mycophenolate mofetil as an immunomodulatory silver bullet in atherogenesis?

Lupus

Van Leuven, S.I. and Kastelein, J.J.P. and Hayden, M.R. and Stroes, E.S.

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: Effect of histone deacetylase inhibitors

Journal of Neuroscience

Oliveira, J.M.A. and Chen, S. and Almeida, S. and Riley, R. and Gon?alves, J. and Oliveira, C.R. and Hayden, M.R. and Nicholls, D.G. and Ellerby, L.M. and Rego, A.C.

Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Van Eck, M. and Singaraja, R.R. and Ye, D. and Hildebrand, R.B. and James, E.R. and Hayden, M.R. and Van Berkel, T.J.C.

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

Neurobiology of Disease

Guidetti, P. and Bates, G.P. and Graham, R.K. and Hayden, M.R. and Leavitt, B.R. and MacDonald, M.E. and Slow, E.J. and Wheeler, V.C. and Woodman, B. and Schwarcz, R.

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease

Neurobiology of Disease

Kishikawa, S. and Li, J.-L. and Gillis, T. and Hakky, M.M. and Warby, S. and Hayden, M. and MacDonald, M.E. and Myers, R.H. and Gusella, J.F.

Ethyl-EPA in Huntington's disease: A double blind, randomised, placebo controlled trial

Journal of Neurology Neurosurgery and Psychiatry

Murck, H and Manku, M and Puri, BK and Leavitt, BR and Hayden, MR and Ross, CA and Rosenblatt, A and Greenamyre, JT and Hersch, S and Vaddadi, KS

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

Human Molecular Genetics

Van Raamsdonk, J.M. and Murphy, Z. and Slow, E.J. and Leavitt, B.R. and Hayden, M.R.

Selective degeneration and nuclear localisation of mutant huntingtin in the YAC128 mouse model of Huntington's disease

Journal of Neurology Neurosurgery and Psychiatry

Van Raamsdonk, JM and Murphy, Z and Slow, EJ and Leavitt, BR and Hayden, MR

Links between proteolysis and neurotoxicity identify novel approaches for modifying the pathogenesis of Huntington's disease

Journal of Neurology Neurosurgery and Psychiatry

Graham, RK and Yanai, A and El Husseini, A and Hayden, MR

Histone acetylation and recovery from excitotoxicity in striatal cells expressing full length mutant huntingtin

Journal of Neurology Neurosurgery and Psychiatry

Oliveira, JM and Chen, SF and Almeida, S and Riley, R and Goncalves, J and Oliveira, CR and Hayden, MR and Nicholls, DG and Ellerby, LM and Rego, AC

Gene therapy for lipoprotein lipase deficiency: Working toward clinical application

Human Gene Therapy

Rip, J. and Nierman, M.C. and Sierts, J.A. and Petersen, W. and Van Den Oever, K. and Van Raalte, D. and Ross, C.J.D. and Hayden, M.R. and Bakker, A.C. and Dijkhuizen, P. and Hermens, W.T. and Twisk, J. and Stroes, E. and Kastelein, J.J.P. and Kuivenhoven, J.A. and Meulenberg, J.M.

Experimental models of Huntington's disease

Drug Discovery Today: Disease Models

Van Raamsdonk, J.M. and Hayden, M.R. and Leavitt, B.R.

Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease

Journal of Neurochemistry

Jenkins, B.G. and Andreassen, O.A. and Dedeoglu, A. and Leavitt, B. and Hayden, M. and Borchelt, D. and Ross, C.A. and Ferrante, R.J. and Beal, M.F.

Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis

Journal of Lipid Research

Coutinho, J.M. and Singaraja, R.R. and Kang, M. and Arenillas, D.J. and Bertram, L.N. and Bissada, N. and Staels, B. and Fruchart, J.-C. and Fievet, C. and Joseph-George, A.M. and Wasserman, W.W. and Hayden, M.R.

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease

Journal of Biological Chemistry

Hirsch-Reinshagen, V. and Maia, L.F. and Burgess, B.L. and Blain, J.-F. and Naus, K.E. and McIsaac, S.A. and Parkinson, P.F. and Chan, J.Y. and Tansley, G.H. and Hayden, M.R. and Poirier, J. and Van Nostrand, W. and Wellington, C.L.

MR spectroscopy shows metabolic changes in transgenic Huntington's disease mice

Nordic Journal of Psychiatry

Andreassen, OA and Jenkins, BG and Kuesterman, E and Dedeoglu, A and Hayden, MR and Ross, CA and Borchelt, DR and Beal, MF

Huntingtin Interacting Protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain

Journal of Biological Chemistry

Legendre-Guillemin, V. and Metzler, M. and Lemaire, J.-F. and Philie, J. and Gan, L. and Hayden, M.R. and McPherson, P.S.

HOXA7 protein expression in human normal ovary

Journal of the Society for Gynecologic Investigation

Ota, T. and Kwok, A. and Choi, K. B. and Pang, L. and Gilks, B. and Jefferies, W. A. and Hayden, M. R. and Leung, P. C. K. and Auersperg, N.

Essential role of ABCA1 in HDL catabolism in mice

Arteriosclerosis Thrombosis and Vascular Biology

Rinninger, F. and Brundert, M. and Merkel, M. and Heeren, J. and Hayden, M. and Singaraja, R.

Cardiovascular disease in systemic lupus erythematosus: Has the time for action come?

Current Opinion in Lipidology

Van Leuven, S.I. and Kastelein, J.J.P. and Hayden, M.R. and D'Cruz, D. and Hughes, G.R. and Stroes, E.S.

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene

PLoS Genetics

Brunham, L.R. and Singaraja, R.R. and Pape, T.D. and Kejariwal, A. and Thomas, P.D. and Hayden, M.R.

W10 regulation of plasma HDL levels and metabolism

Atherosclerosis Supplements

Van Berkel, T. and Out, R. and Hoekstra, M. and Hildebrand, R. B. and Kruijt, K. and Singaraja, R. and Kaminski, W. E. and Schmitz, G. and Hayden, M. and Van Eck, M.

Tissue specific deletion of enterocyte ABCA1 identifies the intestine as a significant source of plasma HDL cholesterol in vivo

Arteriosclerosis Thrombosis and Vascular Biology

Brunham, LR and Pape, TD and Flevet, C and Timmins, JM and Bissada, N and Coburn, BA and Staels, B and Parks, JS and Hayden, MR

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

Human Molecular Genetics

Van Raamsdonk, J.M. and Pearson, J. and Rogers, D.A. and Bissada, N. and Vogl, A.W. and Hayden, M.R. and Leavitt, B.R.

From genes to therapies: AAV-mediated gene therapy for LPL deficiency

Circulation

Ross, CJ and Twisk, J and Rip, J and Nierman, MC and Dijkhuizen, P and Hermens, WT and Meulenberg, JM and Kastelein, JJ and Kuivenhoven, JA and Hayden, MR

Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation

Arteriosclerosis Thrombosis and Vascular Biology

Ross, C.J.D. and Liu, G. and Kuivenhoven, J.A. and Twisk, J. and Rip, J. and Van Dop, W. and Excoffon, K.J.D.A. and Lewis, S.M.E. and Kastelein, J.J. and Hayden, M.R.

Ethyl-EPA in Huntington disease: A double-blind, randomized, placebo-controlled trial

Neurology

Puri, B.K. and Leavitt, B.R. and Hayden, M.R. and Ross, C.A. and Rosenblatt, A. and Greenamyre, J.T. and Hersch, S. and Vaddadi, K.S. and Sword, A. and Horrobin, D.F. and Manku, M. and Murck, H.

Disturbed Ca2+ signalling and apoptosis of medium spiny neurons in Huntington's disease

Proceedings of the National Academy of Sciences of the United States of America

Tang, T.-S. and Slow, E. and Lupu, V. and Stavrovskaya, I.G. and Sugimori, M. and Llins, R. and Kristal, B.S. and Hayden, M.R. and Bezprozvanny, I.

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

Neurobiology of Disease

Devon, R.S. and Schwab, C. and Topp, J.D. and Orban, P.C. and Yang, Y.-Z. and Pape, T.D. and Helm, J.R. and Davidson, T.-L. and Rogers, D.A. and Gros-Louis, F. and Rouleau, G. and Horazdovsky, B.F. and Leavitt, B.R. and Hayden, M.R.

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease

Journal of Neuroscience

Van Raamsdonk, J.M. and Pearson, J. and Slow, E.J. and Hossain, S.M. and Leavitt, B.R. and Hayden, M.R.

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

Proceedings of the National Academy of Sciences of the United States of America

Slow, E.J. and Graham, R.K. and Osmand, A.P. and Devon, R.S. and Lu, G. and Deng, Y. and Pearson, J. and Vaid, K. and Bissada, N. and Wetzel, R. and Leavitt, B.R. and Hayden, M.R.

Transglutaminases in Huntington disease (HD)

Journal of Neurochemistry

Cooper, AJ and Krasnikov, BF and Pinto, JT and Van Raamsdonk, JM and Hayden, MR and Leavitt, BR and Jeitner, TM

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

Journal of Clinical Investigation

Timmins, J.M. and Lee, J.-Y. and Boudyguina, E. and Kluckman, K.D. and Brunham, L.R. and Mulya, A. and Gebre, A.K. and Coutinho, J.M. and Colvin, P.L. and Smith, T.L. and Hayden, M.R. and Maeda, N. and Parks, J.S.

Psychosocial effects of predictive testing for Huntington's disease.

Advances in neurology

Hayden, M.R. and Bombard, Y.

Huntington's disease: Lessons for ChAc

Movement Disorders

Hayden, MR

Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1

Journal of Lipid Research

Singaraja, R.R. and James, E.R. and Crim, J. and Visscher, H. and Chatterjee, A. and Hayden, M.R.

Increased expression of ABCA1 provides significant protection against atherosclerosis

Circulation

Singaraja, RR and Fievet, C and Bissada, N and Kang, M and McManus, B and Staels, B and Hayden, MR

Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: Implications for the treatment of Huntington disease

Journal of Neurochemistry

Pinto, J.T. and Van Raamsdonk, J.M. and Leavitt, B.R. and Hayden, M.R. and Jeitner, T.M. and Thaler, H.T. and Krasnikov, B.F. and Cooper, A.J.L.

Introduction to Social and Behavioural Research in genetics

Clinical Genetics

Hayden, M.R. and Biesecker, B.

Intestinal ABCA1 is a significant contributor to plasma HDL-C and apoB levels in vivo

Circulation

Brunham, L and Kruit, JK and Pape, TD and Havinga, R and Flevet, C and Timmins, JM and Bissada, N and Staels, B and Groen, AK and Parks, JS and Kuipers, F and Hayden, MR

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

Human Molecular Genetics

Warby, S.C. and Chan, E.Y. and Metzler, M. and Gan, L. and Singaraja, R.R. and Crocker, S.F. and Robertson, H.A. and Hayden, M.R.

Huntingtin associates with acidic phospholipids at the plasma membrane

Journal of Biological Chemistry

Kegel, K.B. and Sapp, E. and Yoder, J. and Cuiffo, B. and Sobin, L. and Kim, Y.J. and Qin, Z.-H. and Hayden, M.R. and Aronin, N. and Scott, D.L. and Isenberg, G. and Goldmann, W.H. and DiFiglia, M.

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease

Journal of Neurochemistry

Van Raamsdonk, J.M. and Pearson, J. and Bailey, C.D.C. and Rogers, D.A. and Johnson, G.V.W. and Hayden, M.R. and Leavitt, B.R.

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease

Experimental Neurology

Van Raamsdonk, J.M. and Pearson, J. and Rogers, D.A. and Lu, G. and Barakauskas, V.E. and Barr, A.M. and Honer, W.G. and Hayden, M.R. and Leavitt, B.R.

A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis

Clinical Genetics

Delatycki, M.B. and Allen, K.J. and Gow, P. and MacFarlane, J. and Radomski, C. and Thompson, J. and Hayden, M.R. and Goldberg, Y.P. and Samuels, M.E.

The contribution of hepatic adenosine triphosphate-binding cassette transporter, ABCA1, to high-density lipoprotein cholesterol levels in vivo.

Journal of Investigative Medicine

Brunham, LR and Wellington, CL and Orban, PC and Deng, Y and Hayden, MR

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

Journal of Lipid Research

Selva, D.M. and Hirsch-Reinshagen, V. and Burgess, B. and Zhou, S. and Chan, J. and McIsaac, S. and Hayden, M.R. and Hammond, G.L. and Vogl, A.W. and Wellington, C.L.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

Cell Death and Differentiation

Hermel, E. and Gafni, J. and Propp, S.S. and Leavitt, B.R. and Wellington, C.L. and Young, J.E. and Hackam, A.S. and Logvinova, A.V. and Peel, A.L. and Chen, S.F. and Hook, V. and Singaraja, R. and Krajewski, S. and Goldsmith, P.C. and Ellerby, H.M. and Hayden, M.R. and Bredesen, D.E. and Ellerby, L.M.

HDL deficiency and atherosclerosis: Lessons from Tangier disease [1]

Journal of Internal Medicine

Hovingh, G.K. and Kuivenhoven, J.A. and Bisoendial, R.J. and Groen, A.K. and Van Dam, M. and Van Tol, A. and Wellington, C. and Hayden, M.R. and Smelt, A.H.M. and Kastelein, J.J.P.

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

Journal of Neurophysiology

Li, L. and Murphy, T.H. and Hayden, M.R. and Raymond, L.A.

Correction of dyslipidemia in murine and feline models of lipoprotein lipase deficiency by intramuscular administration of AAV1-LPLS447X

Molecular Therapy

Ross, CJD and Twisk, J and Kuivenhoven, JA and Liu, GQ and Miao, FD and van den Oever, K and Beetz, M and Verbart, D and Bakker, A and Oranje, PPA and Hermens, WT and Dijkhuizen, P and Kastelein, JJP and Meulenberg, JJM and Hayden, MR

ABCA1-mediated lipid transport from both the liver and the periphery are essential for maintenance of plasma HDL levels in vivo

Circulation

Singaraja, RR and Coutinho, JM and Ross, C and Bissada, N and Kang, MH and Brunham, LR and Timmins, JM and Miao, F and Parks, JS and Hayden, MR

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length

Clinical Genetics

Langbehn, D.R. and Brinkman, R.R. and Falush, D. and Paulsen, J.S. and Hayden, M.R.

The endocytic protein HIP1 influences NMDAR function

Molecular Biology of the Cell

Metzler, M and Gan, L and Wong, TP and Liu, L and Helm, J and Wang, YS and Wang, YT and Hayden, MR

Mutations in LCAT, ApoA-I, and ABCA1 can be distinguished by NMR lipoprotein subphenotyping

Arteriosclerosis Thrombosis and Vascular Biology

Brownlie, A and Hovingh, GK and Coutinho, J and Dube, MP and Klerkx, AH and Otvos, JD and Ludwig, EH and Kastelein, JJ and Hayden, MR and Kuivenhoven, JA

Humanized transgenic ABCA1 mice show complete functional rescue of mouse ABCA1 deficiency

Arteriosclerosis Thrombosis and Vascular Biology

Coutinho, J and Singaraja, R and Kang, M and Fievet, C and Hayden, MR

HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca2+ release in primary culture of striatal medium spiny neurons

European Journal of Neuroscience

Tang, T.-S. and Tu, H. and Orban, P.C. and Chan, E.Y.W. and Hayden, M.R. and Bezprozvanny, I.

Tissue-specific hepatic deletion of ABCA1 indicates that the liver is the primary site of HDL formation in vivo

Arteriosclerosis Thrombosis and Vascular Biology

Timmins, JM and Lee, JY and Mulya, A and Kluckman, K and Brunham, LR and Hayden, MR and Maeda, N and Parks, JS

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

Molecular and Cellular Biology

Trushina, E. and Dyer, R.B. and Badger II, J.D. and Ure, D. and Eide, L. and Tran, D.D. and Vrieze, B.T. and Legendre-Guillemin, V. and McPherson, P.S. and Mandavilli, B.S. and Van Houten, B. and Zeitlin, S. and McNiven, M. and Aebersold, R. and Hayden, M. and Parisi, J.E. and Seeberg, E. and Dragatsis, I. and Doyle, K. and Bender, A. and Chacko, C. and McMurray, C.T.

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

Experimental Neurology

Zala, D. and Bensadoun, J.-C. and De Almeida, L.P. and Leavitt, B.R. and Gutekunst, C.-A. and Aebischer, P. and Hayden, M.R. and Dglon, N.

Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: A marker of cardiac dilatation

Molecular and Cellular Biochemistry

Reddy, HK and Tjahja, IE and Campbell, SE and Janicki, JS and Hayden, MR and Tyagi, SC

Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16

Neurogenetics

Djouss, L. and Knowlton, B. and Hayden, M.R. and Almqvist, E.W. and Brinkman, R.R. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Durr, A. and Dode, C. and Morrison, P.J. and Novelletto, A. and Frontali, M. and Trent, R.J.A. and McCusker, E. and Gmez-Tortosa, E. and Cabrero, D.M. and Jones, R. and Zanko, A. and Nance, M. and Abramson, R.K. and Suchowersky, O. and Paulsen, J.S. and Harrison, M.B. and Yang, Q. and Cupples, L.A. and Mysore, J. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.

A case of tangier disease with a novel mutation in the C-terminal region of ATP-binding cassette transporter A1

American Journal of Medical Genetics

Guan, J.-Z. and Tamasawa, N. and Brunham, L.R. and Matsui, J. and Murakami, H. and Suda, T. and Ochiai, S. and Tsutsui, M. and Kudou, K. and Satoh, K. and Hayden, M.R.

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

Molecular and Cellular Neuroscience

Zeron, M.M. and Fernandes, H.B. and Krebs, C. and Shehadeh, J. and Wellington, C.L. and Leavitt, B.R. and Baimbridge, K.G. and Hayden, M.R. and Raymond, L.A.

Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPLS447X beneficial mutation

Human Gene Therapy

Ross, C.J.D. and Twisk, J. and Meulenberg, J.M. and Liu, G. and Van Den Oever, K. and Moraal, E. and Hermens, W.T. and Rip, J. and Kastelein, J.J.P. and Kuivenhoven, J.A. and Hayden, M.R.

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

Nature

Saleh, M. and Vaillancourt, J.P. and Graham, R.K. and Huyck, M. and Srinivasula, S.M. and Alnemri, E.S. and Steinberg, M.H. and Holan, V. and Baldwin, C.T. and Hotchkiss, R.S. and Buchman, T.G. and Zehnbauer, B.A. and Hayden, M.R. and Farrer, L.A. and Roy, S. and Nicholson, D.W.

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length (vol 65, pg 267, 2004)

Clinical Genetics

Langbehn, DR and Brinkman, RR and Falush, D and Paulsen, JS and Hayden, MR and Int Huntingtons Dis Collaborative

Identification of a Novel Gene (HSN2) Causing Hereditary Sensory and Autonomic Neuropathy Type II through the Study of Canadian Genetic Isolates

American Journal of Human Genetics

Lafrenire, R.G. and MacDonald, M.L.E. and Dub, M.-P. and MacFarlane, J. and O'Driscoll, M. and Brais, B. and Meilleur, S. and Brinkman, R.R. and Dadivas, O. and Pape, T. and Platon, C. and Radomski, C. and Risler, J. and Thompson, J. and Guerra-Escobio, A.-M. and Davar, G. and Breakefield, X.O. and Pimstone, S.N. and Green, R. and Pryse-Phillips, W. and Goldberg, Y.P. and Younghusband, H.B. and Hayden, M.R. and Sherrington, R. and Rouleau, G.A. and Samuels, M.E.

Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins

Neuron

Huang, K. and Yanai, A. and Kang, R. and Arstikaitis, P. and Singaraja, R.R. and Metzler, M. and Mullard, A. and Haigh, B. and Gauthier-Campbell, C. and Gutekunst, C.-A. and Hayden, M.R. and El-Husseini, A.

Genetic testing and Huntington's disease: Issues of employment

Lancet Neurology

Harper, P.S. and Gevers, S. and De Wert, G. and Creighton, S. and Bombard, Y. and Hayden, M.R.

ABCA1 modulates APOE levels in brain and plasma

Neurobiology of Aging

Hirsch-Reinshagen, V. and Zhou, S. and Chan, J. and McIsaac, S. and Cohn, J. and Hayden, M. and Wellington, C.

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

Journal of the American College of Cardiology

Hovingh, G.K. and Brownlie, A. and Bisoendial, R.J. and Dube, M.P. and Levels, J.H.M. and Petersen, W. and Dullaart, R.P.F. and Stroes, E.S.G. and Zwinderman, A.H. and De Groot, E. and Hayden, M.R. and Kuivenhoven, J.A. and Kastelein, J.J.P.

Huntington's disease-like 2 (HDL2) in North America and Japan

Annals of Neurology

Margolis, R.L. and Holmes, S.E. and Rosenblatt, A. and Gourley, L. and O'Hearn, E. and Ross, C.A. and Seltzer, W.K. and Walker, R.H. and Ashizawa, T. and Rasmussen, A. and Hayden, M. and Almqvist, E.W. and Harris, J. and Fahn, S. and MacDonald, M.E. and Mysore, J. and Shimohata, T. and Tsuji, S. and Potter, N. and Nakaso, K. and Adachi, Y. and Nakashima, K. and Bird, T. and Krause, A. and Greenstein, P.

Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction

Journal of Neuroscience

Qin, Z.-H. and Wang, Y. and Sapp, E. and Cuiffo, B. and Wanker, E. and Hayden, M.R. and Kegel, K.B. and Aronin, N. and DiFiglia, M.

Erratum: A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length (Clinical Genetics (2004) vol. 65 (267-277))

Clinical Genetics

Langbehn, D.R. and Brinkman, R.R. and Falush, D. and Paulsen, J.S. and Hayden, M.R.

Deranged neuronal calcium signaling and Huntington disease

Biochemical and Biophysical Research Communications

Bezprozvanny, I. and Hayden, M.R.

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

Journal of Biological Chemistry

Hirsch-Reinshagen, V. and Zhou, S. and Burgess, B.L. and Bernier, L. and McIsaac, S.A. and Chan, J.Y. and Tansley, G.H. and Cohn, J.S. and Hayden, M.R. and Wellington, C.L.

Palmitoylation of ABCA1 is required for its normal trafficking to the plasma membrane and for lipid efflux activity

Circulation

Singaraja, RR and Kang, MH and Coutinho, JM and Arstikaitis, P and El Husseini, A and Hayden, MR

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

Nature Genetics

Papanikolaou, G. and Samuels, M.E. and Ludwig, E.H. and MacDonald, M.L.E. and Franchini, P.L. and Dub, M.-P. and Andres, L. and MacFarlane, J. and Sakellaropoulos, N. and Politou, M. and Nemeth, E. and Thompson, J. and Risler, J.K. and Zaborowska, C. and Babakaiff, R. and Radomski, C.C. and Pape, T.D. and Davidas, O. and Christakis, J. and Brissot, P. and Lockitch, G. and Ganz, T. and Hayden, M.R. and Goldberg, Y.P.

Inhibition of calpain cleavage of Huntingtin reduces toxicity: Accumulation of calpain/caspase fragments in the nucleus

Journal of Biological Chemistry

Gafni, J. and Hermel, E. and Young, J.E. and Wellington, C.L. and Hayden, M.R. and Ellerby, L.M.

Erratum: Huntington's disease-like 2 (HDL2) in North America and Japan (Annals of Neurology (November 2004) 56 (670-674))

Annals of Neurology

Margolis, R.L. and Holmes, S.E. and Rosenblatt, A. and Gourley, L. and O'Hearn, E. and Ross, C.A. and Seltzer, W.K. and Walker, R.H. and Ashizawa, T. and Rasmussen, A. and Hayden, M. and Almqvist, E.W. and Harris, J. and Fahn, S. and MacDonald, M.E. and Mysore, J. and Shimohata, T. and Tsuji, S. and Potter, N. and Nakaso, K. and Adachi, Y. and Nakashima, K. and Bird, T. and Krause, A. and Greenstein, P.

Clinical and radiographic features among presymptomatic individuals carrying an expanded CAG repeat in the Huntington's disease gene: Analysis of baseline characteristics of the PREDICT-HD cohort

Neurology

Ross, C. A. and Aylward, E. H. and Stout, J. C. and Biglan, K. M. and Hayden, M. R. and Shoulson, I. and Langbehn, D. R. and Paulsen, J. S. and Predict, H. D. Investigators H. S. D.

A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study

American Journal of Human Genetics

Li, J.-L. and Hayden, M.R. and Almqvist, E.W. and Brinkman, R.R. and Durr, A. and Dod, C. and Morrison, P.J. and Suchowersky, O. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Gmez-Tortosa, E. and Cabrero, D.M. and Novelletto, A. and Frontali, M. and Nance, M. and Trent, R.J.A. and McCusker, E. and Jones, R. and Paulsen, J.S. and Harrison, M. and Zanko, A. and Abramson, R.K. and Russ, A.L. and Knowlton, B. and Djouss, L. and Mysore, J.S. and Tariot, S. and Gusella, M.F. and Wheeler, V.C. and Atwood, L.D. and Cupples, L.A. and Saint-Hilaire, M. and Cha, J.-H.J. and Hersch, S.M. and Koroshetz, W.J. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

Human Molecular Genetics

Slow, E.J. and van Raamsdonk, J. and Rogers, D. and Coleman, S.H. and Graham, R.K. and Deng, Y. and Oh, R. and Bissada, N. and Hossain, S.M. and Yang, Y.-Z. and Li, X.-J. and Simpson, E.M. and Gutekunst, C.-A. and Leavitt, B.R. and Hayden, M.R.

Clarity is essential when using Nucleotide number systems

Atherosclerosis

Brunham, L.R. and Hayden, M.R.

A genetic, biochemical and proteomic approach to dissection of inherited HDL phenotypes in humans

Atherosclerosis Supplements

Brownlie, A. and Ludwig, E. and Hovingh, K. and Van Wijland, M. and Bisoendial, R. and Klerkx, A. and Dube, M. P. and Samuels, M. and Groen, A. and Kastelein, J. and Hayden, M.

Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein

Circulation

Bisoendial, R.J. and Hovingh, G.K. and Levels, J.H.M. and Lerch, P.G. and Andresen, I. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.G.

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

Journal of Biological Chemistry

Nucifora Jr., F.C. and Ellerby, L.M. and Wellington, C.L. and Wood, J.D. and Herring, W.J. and Sawa, A. and Hayden, M.R. and Dawson, V.L. and Dawson, T.M. and Ross, C.A.

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

EMBO Journal

Metzler, M. and Li, B. and Gan, L. and Georgiou, J. and Gutekunst, C.-A. and Wang, Y. and Torre, E. and Devon, R.S. and Oh, R. and Legendre-Guillemin, V. and Rich, M. and Alvarez, C. and Gertsenstein, M. and McPhersons, P.S. and Nagy, A. and Wang, Y.T. and Roder, J.C. and Raymond, L.A. and Hayden, M.R.

Biochemical characterization of mutations in ABCA1 correlate with disease severity

Atherosclerosis Supplements

Singaraja, R. and Visscher, H. and James, E. and Hayden, M.

ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens

Journal of Biological Chemistry

Mulligan, J.D. and Flowers, M.T. and Tebon, A. and Bitgood, J.J. and Wellington, C. and Hayden, M.R. and Attie, A.D.

A novel CETP mutation (IVS7+1) in a family of Dutch descent with hyperalphalipoproteinemia

Circulation

Klerkx, AH and Hovingh, GK and Nootenboom, IC and Brownlie, AJ and van Tol, A and Hayden, MR and Kastelein, JJ and Kuivenhoven, JA

Skewed X-chromosome inactivation is associated with trisomy in women ascertained on the basis of recurrent spontaneous abortion or chromosomally abnormal pregnancies

American Journal of Human Genetics

Beever, C.L. and Stephenson, M.D. and Peaherrera, M.S. and Jiang, R.H. and Kalousek, D.K. and Hayden, M. and Field, L. and Brown, C.J. and Robinson, W.P.

Mutations in a novel gene cause hereditary sensory and autonomic neuropathy type II

American Journal of Human Genetics

Samuels, M. and Lafreniere, R. and MacDonald, M. and MacFarlane, J. and Dube, M. P. and O'Driscoll, M. and Meilleur, S. and Thompson, J. and Goldberg, Y. P. and Brais, B. and Pryse-Phillips, W. and Green, R. and Younghusband, B. and Hayden, M. and Sherrington, R. and Rouleau, G.

Mutant frizzled-4 (FZD4) causes autosomal dominant familial exudative vitreoretinopathy (FEVR) with variable intrafamilial phenotype

Investigative Ophthalmology & Visual Science

Robitaille, JM and MacDonald, MLE and Guernsey, DL and Zheng, B and Siebert, LS and Hoskin-Mott, A and Beis, MJ and Hayden, MR and Goldberg, YP and Samuels, ME

Macrophage ABCA1 overexpression inhibits atherosclerotic lesion progression

Atherosclerosis Supplements

Van Eck, M and Singaraja, RR and Hildebrand, RB and James, ER and Hayden, MR and Van Berkel, TJC

Long-term correction of murine lipoprotein lipase (LPL) deficiency by a single intramuscular administration of AAV1-LPLS447X

Circulation

Ross, CJ and Twisk, J and Kuivenhoven, JA and Liu, GQG and Miao, F and Scheenhart-van der Meer, JW and Bakker, A and Moraal, E and Oranje, PP and Hermens, WT and Kastelein, JJ and Meulenberg, JJ and Hayden, MR

Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease

American Journal of Medical Genetics

Djouss, L. and Knowlton, B. and Hayden, M. and Almqvist, E.W. and Brinkman, R. and Ross, C. and Margolis, R. and Rosenblatt, A. and Durr, A. and Dode, C. and Morrison, P.J. and Novelletto, A. and Frontali, M. and Trent, R.J.A. and McCusker, E. and Gmez-Tortosa, E. and Mayo, D. and Jones, R. and Zanko, A. and Nance, M. and Abramson, R. and Suchowersky, O. and Paulsen, J. and Harrison, M. and Yang, Q. and Cupples, L.A. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.

A novel apoA-I mutation (Leu178Pro), identified by whole genome linkage approach, predisposes to endothelial dysfunction, increased arterial wall thickness and premature coronary artery disease

Atherosclerosis Supplements

Hovingh, GK and Bisoendial, RJ and Brownlie, A and Samuels, M and Kuivenhoven, JA and De Groot, E and Stroes, ESG and Hayden, MR and Kastelein, JJP

Restoration of endothelial function by increasing HDL in subjects with isolated low-HDL

Atherosclerosis Supplements

Bisoendial, RJ and Hovingh, GK and Levels, JHM and Lerch, PG and Andresen, I and Hayden, MR and Kastelein, JJP and Stroes, ESG

Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease

Clinical Genetics

Almqvist, E.W. and Brinkman, R.R. and Wiggins, S. and Hayden, M.R. and Nicolson Klimek, M.L. and Trew, M. and Suchowersky, O. and Grover, S. and Bamforth, S. and Adam, S. and Huggins, M. and Bloch, M. and Green, T. and Greenberg, C. and Ives, E. and Fuller, A. and Welch, P. and Eisenberg, D. and Whelan, D. and Kane, J. and Soltan, H. and MacGregor, D. and Summers, A. and Meschino, W. and Prevost, C. and Dunfrasne, S. and Roy, M. and Rosenblatt, D. and Cardwell, S. and Gibson, A. and Shokeir, M.H.K.

Preface

Clinical Neuroscience Research

Wellington, C.L. and Hayden, M.R.

Predictive testing for persons at risk for homozygosity for CAG expansion in the Huntington disease gene [4]

Clinical Genetics

Squitieri, F. and Almqvist, E.W. and Cannella, M. and Cislaghi, G. and Hayden, M.R.

Disruption of the endocytic protein HIP1 results in major neurological deficits and decreased AMPA receptor trafficking

American Journal of Human Genetics

Metzler, MM and Gan, L and Li, B and Georgiou, J and Gutekunst, CA and Wang, Y and Torre, E and Wang, YT and Roder, JC and Raymond, LA and Hayden, MR

Depletion of wild-type huntingtin in mouse models of neurologic diseases

Journal of Neurochemistry

Zhang, Y. and Li, M. and Drozda, M. and Chen, M. and Ren, S. and Sanchez, R.O.M. and Leavitt, B.R. and Cattaneo, E. and Ferrante, R.J. and Hayden, M.R. and Friedlander, R.M.

Working towards clinical application of gene therapy for LPL deficiency

Circulation

Rip, J and Nierman, MC and Sierts, JA and van Raalte, D and Petersen, W and van den Oever, K and Ross, CJ and Hayden, MR and Meulenberg, JM and Twisk, J and Kastelein, JJ and Kuivenhoven, JA

Pro-survival effects of wild-type huntingtin in vivo.

American Journal of Human Genetics

Leavitt, BR and Rogers, D and van-Raamsdonk, J and Opina, CJ and Chan, E and Wellington, CL and Hayden, MR

Mutation Screening of the ALS2 Gene in Sporadic and Familial Amyotrophic Lateral Sclerosis

Archives of Neurology

Hand, C.K. and Devon, R.S. and Gros-Louis, F. and Rochefort, D. and Khoris, J. and Meininger, V. and Bouchard, J.-P. and Camu, W. and Hayden, M.R. and Rouleau, G.A.

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

Nature Genetics

Zuccato, C. and Tartari, M. and Crotti, A. and Goffredo, D. and Valenza, M. and Conti, L. and Cataudella, T. and Leavitt, B.R. and Hayden, M.R. and Timmusk, T. and Rigamonti, D. and Cattaneo, E.

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

Neuron

Tang, T.-S. and Tu, H. and Chan, E.Y.W. and Maximov, A. and Wang, Z. and Wellington, C.L. and Hayden, M.R. and Bezprozvanny, I.

Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1

Journal of Lipid Research

Wellington, C.L. and Brunham, L.R. and Zhou, S. and Singaraja, R.R. and Visscher, H. and Gelfer, A. and Ross, C. and James, E. and Liu, G. and Huber, M.T. and Yang, Y.-Z. and Parks, R.J. and Groen, A. and Fruchart-Najib, J. and Hayden, M.R.

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

Journal of Lipid Research

Hovingh, G.K. and Van Wijland, M.J.A. and Brownlie, A. and Bisoendial, R.J. and Hayden, M.R. and Kastelein, J.J.P. and Groen, A.K.

Mutations in the HFE2A gene cause juvenile hemochromatosis

American Journal of Human Genetics

Goldberg, P. and Papanikolaou, G. and Ludwig, E. and MacDonald, M. and Andres, L. and Dube, M. P. and Franchini, P. and Babakaiff, R. and Risler, J. and Zaborowska, C. and Pimstone, S. and Brissot, P. and Lockitch, G. and Hayden, M. and Samuels, M.

Macrophage-specific ATP-Binding cassette transporter 1 (ABCA1) overexpression inhibits atherosclerotic lesion progression

Circulation

Van Eck, M and Singaraja, RR and Hildebrand, RB and James, ER and Hayden, MR and Van Berkel, TJ

Huntington proteolysis in Huntington disease

Clinical Neuroscience Research

Wellington, C.L. and Ellerby, L.M. and Leavitt, B.R. and Roy, S. and Nicholson, D.W. and Hayden, M.R.

Functional effects of tissue-specific expression of ATP-cassette transporter A1 (ABCA1) provide multiple mechanisms for protection against atherosclerosis

Atherosclerosis Supplements

Hayden, M. and Singaraja, R. and Van Eck, M. and Van Berkel, T. and Kastelein, J. J. P.

Functional analysis of mutations in the ABCA1 gene

Journal of Investigative Medicine

Brunham, L. and Singaraja, R. and Visscher, H. and James, E. and Hayden, M.

Distinct cellular and biochemical effects of specific mutations in ABCA1 predicts the phenotype in TD and FHA

American Journal of Human Genetics

Singaraja, R. and Visscher, H. and James, E. and Hayden, M.

CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Laurent, C. and Niehaus, D. and Bauch, S. and Levinson, D.F. and Soubigou, S. and Pimstone, S. and Hayden, M. and Mbanga, I. and Emsley, R. and Deleuze, J.-F. and Mallet, J.

Allelic variation in the promoter region of the LDL receptor gene: Analysis of an African-specific variant in the FP2 cis-acting regulatory element

Molecular and Cellular Probes

Hoogendijk, C.F. and Scholtz, C.L. and Pimstone, S.M. and Ehrenborg, E. and Kastelein, J.J.P. and Defesche, J.C. and Thiart, R. and Du Plessis, L. and De Villiers, J.N.P. and Zaahl, M.G. and Delport, R. and Rubinsztein, D.C. and Raffel, L.J. and Grim, C.E. and Mediene-Benchekor, S. and Amouyel, P. and Brousseau, T. and Steyn, K. and Lombard, C.J. and Hayden, M.R. and Kotze, M.J.

A novel apoAl mutation (Leu178Pro) leads to severely disturbed HDL metabolism, endothelial dysfunction, increased arterial wall thickness and premature coronary artery disease

Circulation

Hovingh, G. K. and Brownlie, A. and Bisoendial, R. J. and Kuivenhoven, J. A. and Levels, J. H. and Dube, M. and Stroes, E. S. and de Groot, E. and Hayden, M. R. and Kastelein, J. J.

The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings

Clinical Genetics

Devon, R.S. and Helm, J.R. and Rouleau, G.A. and Leitner, Y. and Lerman-Sagie, T. and Lev, D. and Hayden, M.R.

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

Neurobiology of Aging

Li, L. and Fan, M. and Icton, C.D. and Chen, N. and Leavitt, B.R. and Hayden, M.R. and Murphy, T.H. and Raymond, L.A.

Predictors of nursing home placement in Huntington disease

Neurology

Wheelock, V.L. and Tempkin, T. and Marder, K. and Nance, M. and Myers, R.H. and Zhao, H. and Kayson, E. and Orme, C. and Shoulson, I. and Hedges, P. and McCusker, E. and Pearce, S. and Trent, R. and Abwender, D. and Como, P. and Gardiner, I. and Hickey, C. and Kieburtz, K. and Marshall, F. and Pearson, N. and Zimmerman, C. and Louis, E. and Moskowitz, C. and Polanco, C. and Zubin, N. and Brown, C. and Burkeholder, J. and Guttman, M. and Russell, S. and Stewart, D. and Thomson, J. and Sax, D.S. and Saint-Hilaire, M. and Gray, J. and Hunter, C. and Mercado, N. and Siemers, E. and Wojeieszek, J. and Dawson, T. and Leritz, E. and Rosenblatt, A. and Sherr, M. and Young, C. and Ashizawa, T. and Beach, J. and Jankovic, J. and Jaglin, J. and Shannon, K. and Lundin, A. and Francis, K. and Lane, K. and Auchus, A. and Greenamyre, J.T. and Hersch, S. and Jones, R. and Olson, D. and Cha, J.-H.J. and Cudkowicz, M. and Koroshetz, W. and Penney, J. and Rudolf, G. and Sexton, P. and Young, A.B. and Albin, R. and Wernette, K. and Higgins, D.S. and Reider, C. and Hunt, V. and Walker, F. and Hauscr, R. and Sanchez-Ramos, J. and Walker, A. and Pantello, C. and Rohs, G. and Suchowersky, O. and Duncan, K. and Seeberger, L. and Corey-Bloom, J. and Paulsen, J. and Swenson, M. and Swerdlow, N. and Martin, W. and Wieler, M. and Facca, A. and Rey, G. and Weiner, W. and Adler, C. and Caviness, J. and Lied, C. and Newman, S. and Feigin, A. and Mazurkiewicz, J. and Caplan, K. and Cellar, J. and Marck, K. and Hayden, M. and Raymond, L. and Dure, L.S. and Lane, J.

Predictive testing for Huntington's disease: A universal model?

Lancet Neurology

Hayden, M.R.

Long-term correction of murine lipoprotein lipase deficiency by single intramuscular administration of AAV1-LPLS447X

Molecular Therapy

Ross, CJD and Meulenberg, JJM and Twisk, J and Kuivenhoven, JA and Liu, GQG and Miao, FD and Moraal, E and Oranje, PPA and Bakker, A and Hermens, WTJMC and Scheenhart-van der Meer, JJW and Kastelein, JJP and Hayden, MR

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course

Brain

Squitieri, F. and Gellera, C. and Cannella, M. and Mariotti, C. and Cislaghi, G. and Rubinsztein, D.C. and Almqvist, E.W. and Turner, D. and Bachoud-Lvi, A.-C. and Simpson, S.A. and Delatycki, M. and Maglione, V. and Hayden, M.R. and Di Donato, S.

Dosage effects of riluzole in Huntington's disease - A multicenter placebo-controlled study

Neurology

Marshall, F. J. and Cudkowicz, M. and Hayden, M. and Kieburtz, K. and Zhao, H. W. and Penney, J. and Dure, L. and Lane, J. and Raymond, L. and Decolongon, J. and Marder, K. and Moskowitz, C. and Dubinsky, R. and Gray, C. and Nance, M. and Radtke, D. and Feigin, A. and Shannon, B. and Higgins, D. and Baic, C. and Shannon, K. and Jaglin, J. and Hauser, R. and Delgado, H. and Almqvist, E. W. and de Blieck, E. A. and Biglan, K. and Hogarth, P. and Brocht, A. and Chadwick, C. and Daigneault, S. and Donaghue, P. and Josephson, L. and Shinaman, A. and Slough, M. and Weaver, C. and Bourgeois, K. and Oakes, D. and Watts, A. and Huntington Study, Grp

Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: The experience in Canada from 1987 to 2000

Clinical Genetics

Creighton, S. and Almqvist, E.W. and MacGregor, D. and Fernandez, B. and Hogg, H. and Beis, J. and Welch, J.P. and Riddell, C. and Lokkesmoe, R. and Khalifa, M. and MacKenzie, J. and Sajoo, A. and Farrell, S. and Robert, F. and Shugar, A. and Summers, A. and Meschino, W. and Allingham-Hawkins, D. and Chiu, T. and Hunter, A. and Allanson, J. and Hare, H. and Schween, J. and Collins, L. and Sanders, S. and Greenberg, C. and Cardwell, S. and Lemire, E. and MacLeod, P. and Hayden, M.R.

Heterozygosity for ABCA1 gene mutations: Effects on enzymes, apolipoproteins and lipoprotein particle size

Atherosclerosis

Kuivenhoven, J.A. and Hovingh, G.K. and Van Tol, A. and Jauhiainen, M. and Ehnholm, C. and Fruchart, J.C. and Brinton, E.A. and Otvos, J.D. and Smelt, A.H.M. and Brownlee, A. and Zwinderman, A.H. and Hayden, M.R. and Kastelein, J.J.P.

Efflux and atherosclerosis: The clinical and biochemical impact of variations in the ABCA1 gene

Arteriosclerosis, Thrombosis, and Vascular Biology

Singaraja, R.R. and Brunham, L.R. and Visscher, H. and Kastelein, J.J.P. and Hayden, M.R.

Caudate volume as an outcome measure in clinical trials for Huntington's disease: A pilot study

Brain Research Bulletin

Aylward, E.H. and Rosenblatt, A. and Field, K. and Yallapragada, V. and Kieburtz, K. and McDermott, M. and Raymond, L.A. and Almqvist, E.W. and Hayden, M. and Ross, C.A.

An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred [2]

Annals of Neurology

Gros-Louis, F. and Meijer, I.A. and Hand, C.K. and Dub, M.-P. and MacGregor, D.L. and Seni, M.-H. and Devon, R.S. and Hayden, M.R. and Andermann, F. and Andermann, E. and Rouleau, G.A.

A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding

Journal of Biological Chemistry

Hussain, N.K. and Yamabhai, M. and Bhakar, A.L. and Metzler, M. and Ferguson, S.S.G. and Hayden, M.R. and McPherson, P.S. and Kay, B.K.

A genome scan for modifiers of age at onset in Huntington's disease: The HD MAPS study

American Journal of Human Genetics

Li, J. L. and Hayden, M. and Almqvist, E. W. and Durr, A. and Dod, C. and Morrison, P. J. and Suchowersky, O. and Ross, C. A. and Margolis, R. L. and Gmez-Tortosa, E. and Mayo, D. and Novelletto, A. and Nance, M. and Trent, R. J. A. and Zanko, A. and Abramson, R. K. and Russ, A. L. and Gusella, J. F. and MacDonald, M. E. and Myers, R. H.

Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency

Biochemical and Biophysical Research Communications

Nishida, Y. and Hirano, K.-I. and Tsukamoto, K. and Nagano, M. and Ikegami, C. and Zhang, Z. and Tsujii, K.-I. and Matsuyama, A. and Ohama, T. and Matsuura, F. and Ishigami, M. and Sakai, N. and Hiraoka, H. and Yamashita, S. and Matsuzawa, Y. and Nagano, M. and Ishihara, M. and Hattori, H. and Egashira, T. and Sakane, N. and Yoshida, Y. and Roomp, K. and Wellington, C. and Hayden, M.R. and Misugi, S.

Skewed XCl in women experiencing a pregnancy with meiotic nondisjunction.

American Journal of Human Genetics

Penaherrera, MS and Beever, CL and Jiang, RH and McFadden, DE and Hayden, MR and Field, LL and Kalousek, DK and Brown, CJ and Robinson, WP

Nuclear localization of a truncation product of mutant atrophin-1, increases cellular toxicity

Molecular Biology of the Cell

Nucifora, FC and Wood, JD and Ellerby, LM and Herring, WJ and Sawa, A and Wellington, CL and Hayden, MR and Dawson, VL and Dawson, TM and Ross, CA

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

Neuron

Zeron, M.M. and Hansson, O. and Chen, N. and Wellington, C.L. and Leavitt, B.R. and Brundin, P. and Hayden, M.R. and Raymond, L.A.

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

Human Molecular Genetics

Chan, E.Y.W. and Luthi-Carter, R. and Strand, A. and Solano, S.M. and Hanson, S.A. and DeJohn, M.M. and Kooperberg, C. and Chase, K.O. and DiFiglia, M. and Young, A.B. and Leavitt, B.R. and Cha, J.-H.J. and Aronin, N. and Hayden, M.R. and Olson, J.M.

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain

Journal of Biological Chemistry

Legendre-Guillemin, V. and Metzler, M. and Charbonneau, M. and Gan, L. and Chopra, V. and Philie, J. and Hayden, M.R. and McPherson, P.S.

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

Journal of Lipid Research

Wellington, C.L. and Yang, Y.-Z. and Zhou, S. and Clee, S.M. and Tan, B. and Hirano, K. and Zwarts, K. and Kwok, A. and Gelfer, A. and Marcil, M. and Newman, S. and Roomp, K. and Singaraja, R. and Collins, J. and Zhang, L.-H. and Groen, A.K. and Hovingh, K. and Brownlie, A. and Tafuri, S. and Genest Jr., J. and Kastelein, J.J.P. and Hayden, M.R.

Striatal neurochemical changes in transgenic models of Huntington's disease

Journal of Neuroscience Research

Ariano, M.A. and Aronin, N. and Difiglia, M. and Tagle, D.A. and Sibley, D.R. and Leavitt, B.R. and Hayden, M.R. and Levine, M.S.

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: An observational study

Lancet

Van Dam, M.J. and De Groot, E. and Clee, S.M. and Hovingh, G.K. and Roelants, R. and Brooks-Wilson, A. and Zwinderman, A.H. and Smit, A.J. and Smelt, A.H.M. and Groen, A.K. and Hayden, M.R. and Kastelein, J.J.P.

Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux

Journal of Biological Chemistry

See, R.H. and Caday-Malcolm, R.A. and Singaraja, R.R. and Zhou, S. and Silverston, A. and Huber, M.T. and Moran, J. and James, E.R. and Janoo, R. and Savill, J.M. and Rigot, V. and Zhang, L.-H. and Wang, M. and Chimini, G. and Wellington, C.L. and Tafuri, S.R. and Hayden, M.R.

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

Nature Neuroscience

Panov, A.V. and Gutekunst, C.-A. and Leavitt, B.R. and Hayden, M.R. and Burke, J.R. and Strittmatter, W.J. and Greenamyre, J.T.

A whole genome linkage approach leads to successful identification of a novel apoA1 mutation causing five percent of familial high-density lipoprotein deficiency in the Dutch population

Circulation

Brownlie, AJ and Hovingh, GK and Kuivenhoven, JA and Dube, MP and Verschoof, H and Samuels, M and Kastelein, JJP and Hayden, MR

A whole genome linkage approach identifies a novel ApoA1 mutation causing five percent of familial hypoalphalipoproteinemia in the Dutch population.

American Journal of Human Genetics

Samuels, M and Hovingh, GK and Kuivenhoven, JA and Dube, MP and Verschoof, H and Goldberg, YP and Kastelein, JJP and Hayden, MR and Brownlie, A

Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken

Journal of Lipid Research

Attie, A.D. and Hamon, Y. and Brooks-Wilson, A.R. and Gray-Keller, M.P. and MacDonald, M.L.E. and Rigot, V. and Tebon, A. and Zhang, L.-H. and Mulligan, J.D. and Singaraja, R.R. and James Bitgood, J. and Cook, M.E. and Kastelein, J.J.P. and Chimini, G. and Hayden, M.R.

PKA site-specific phosphorylation of ABCA1 regulates ApoA-1-dependent phospholipid efflux

Circulation

See, RH and Caday-Malcolm, RA and Singaraja, RR and Zhou, S and Silverston, A and Huber, MT and Moran, J and James, ER and Janoo, R and Zhang, LH and Wang, MH and Wellington, CL and Tafuri, SR and Hayden, MR

Phenotypic description of hereditary sensory neuropathy type 1A (HSN 1A) in two kindreds segregating the same mutation in the gene encoding serine palmitoyl transferase long chain subunit

American Journal of Human Genetics

O'Driscoll, MP and Ainsworth, P and Bieger, D and Goldberg, YP and Green, RC and Hahn, AF and Khani-Hanjani, A and Hayden, MR and MacFarlanes, J and Pryse-Phillips, W and Samuels, M and Younghusband, HB

Increased ABCA1 activity protects against atherosclerosis

Journal of Clinical Investigation

Singaraja, R.R. and Fievet, C. and Castro, G. and James, E.R. and Hennuyer, N. and Clee, S.M. and Bissada, N. and Choy, J.C. and Fruchart, J.-C. and McManus, B.M. and Staels, B. and Hayden, M.L.R.

Frizzled-4 mutations disrupt retinal angiogenesis in familial exudative vitreoretinopathy (FEVR)

American Journal of Human Genetics

MacDonald, MLE and Robitaille, J and Kaykas, A and Sheldahl, L and Dube, MP and Guernsey, D and Zheng, B and Siebert, L and Hoskin-Mott, A and Pimstone, SN and Shastry, BS and Moon, RT and Hayden, MR and Goldberg, YP and Samuels, ME

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease

Journal of Neuroscience

Wellington, C.L. and Ellerby, L.M. and Gutekunst, C.-A. and Rogers, D. and Warby, S. and Graham, R.K. and Loubser, O. and Van Raamsdonk, J. and Singaraja, R. and Yang, Y.-Z. and Gafni, J. and Bredesen, D. and Hersch, S.M. and Leavitt, B.R. and Roy, S. and Nicholson, D.W. and Hayden, M.R.

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

Laboratory Investigation

Wellington, C.L. and Walker, E.K.Y. and Suarez, A. and Kwok, A. and Bissada, N. and Singaraja, R. and Yang, Y.-Z. and Zhang, L.-H. and James, E. and Wilson, J.E. and Francone, O. and McManus, B.M. and Hayden, M.R.

Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior

Human Molecular Genetics

Chan, E.Y.W. and Nasir, J. and Gutekunst, C.-A. and Coleman, S. and Maclean, A. and Maas, A. and Metzler, M. and Gertsenstein, M. and Ross, C.A. and Nagy, A. and Hayden, M.R.

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

Journal of Lipid Research

Attie, A.D. and Krauss, R.M. and Gray-Keller, M.P. and Brownlie, A. and Miyazaki, M. and Kastelein, J.J. and Lusis, A.J. and Stalenhoef, A.F.H. and Stoehr, J.P. and Hayden, M.R. and Ntambi, J.M.

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

Nature Cell Biology

Gervais, F.G. and Singaraja, R. and Xanthoudakis, S. and Gutekunst, C.-A. and Leavitt, B.R. and Metzler, M. and Hackam, A.S. and Tam, J. and Vaillancourt, J.P. and Houtzager, V. and Rasper, D.M. and Roy, S. and Hayden, M.R. and Nicholson, D.W.

Proteomics of clathrin-coated vesicles: Identification of novel endocytic proteins

Faseb Journal

McPherson, PS and Legendre-Guillemin, V and Metzler, M and Hayden, MR and Bell, AW and Wasiak, S

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

Nature Genetics

Robitaille, J. and MacDonald, M.L.E. and Kaykas, A. and Sheldahl, L.C. and Zeisler, J. and Dub, M.-P. and Zhang, L.-H. and Singaraja, R.R. and Guernsey, D.L. and Zheng, B. and Siebert, L.F. and Hoskin-Mott, A. and Trese, M.T. and Pimstone, S.N. and Shastry, B.S. and Moon, R.T. and Hayden, M.R. and Paul Goldberg, Y. and Samuels, M.E.

Increased HDL and changes in lipoprotein composition are associated with increased efflux and atheroprotection in an ABCA1 BAC transgenic mouse model

Circulation

Singaraja, RR and Fievet, C and Castro, G and James, E and Clee, S and Hennuyer, N and Choy, J and Bissada, N and McManus, B and Staels, B and Hayden, MR

ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels

Clinical Genetics

Zwarts, K.Y. and Clee, S.M. and Zwinderman, A.H. and Engert, J.C. and Singaraja, R. and Loubser, O. and James, E. and Roomp, K. and Hudson, T.J. and Jukema, J.W. and Kastelein, J.J.P. and Hayden, M.R.

Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene

Journal of Lipid Research

Peterson, J. and Ayyobi, A.F. and Yuanhong, M. and Henderson, H. and Reina, M. and Deeb, S.S. and Santamarina-Fojo, S. and Hayden, M.R. and Brunzell, J.D.

Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract

Nature Genetics

Bu, L. and Jin, Y. and Shi, Y. and Chu, R. and Ban, A. and Eiberg, H. and Andres, L. and Jiang, H. and Zheng, G. and Qian, M. and Cui, B. and Xia, Y. and Liu, J. and Hu, L. and Zhao, G. and Hayden, M.R. and Kong, X.

Long-term efficacy of a single administration of AAV lipoprotein lipase gene therapy corrects murine hypertriglyceridemia and raises HDL

Circulation

Ross, CJD and Kuivenhoven, JA and Liu, GQG and Miao, F and Scheenhart-van der Meer, JWC and Moraal, E and Oranje, PPA and Hermens, WTJMC and Kastelein, JJP and Hayden, MR and Meulenberg, JJM

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

Human Molecular Genetics

Singaraja, R.R. and Hadano, S. and Metzler, M. and Givan, S. and Wellington, C.L. and Warby, S. and Yanai, A. and Gutekunst, C.-A. and Leavitt, B.R. and Yi, H. and Fichter, K. and Gan, L. and McCutcheon, K. and Chopra, V. and Michel, J. and Hersch, S.M. and Ikeda, J.-E. and Hayden, M.R.

HIP1 and HIP12 are interacting family members that display differential binding to clathrin, AP2 and F-actin

Molecular Biology of the Cell

Legendre-Guillemin, V and Metzler, MM and Charbonneau, M and Gan, L and Chopra, V and Kwok, A and Hayden, MR and McPherson, PS

Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis

Journal of Lipid Research

Attie, AD and Kastelein, JP and Hayden, MR

Onset and pre-onset studies to define the Huntington's disease natural history

Brain Research Bulletin

Squitieri, F. and Cannella, M. and Giallonardo, P. and Maglione, V. and Mariotti, C. and Hayden, M.R.

Clinical markers of early disease in persons near onset of Huntington's disease

Neurology

Paulsen, J.S. and Zhao, H. and Stout, J.C. and Brinkman, R.R. and Guttman, M. and Ross, C.A. and Como, P. and Manning, C. and Hayden, M.R. and Shoulson, I.

A one-hit model of cell death in inherited neuronal degenerations (vol 406, pg 195, 2000)

Nature

Clarke, G and Collins, RA and Leavitt, BR and Andrews, DF and Hayden, MR and Lumsden, CJ and McInnes, RR

Pivotal role of ABCA1 in reverse cholesterol transport influencing HLD levels and susceptibility to atherosclerosis

Journal of Lipid Research

Attie, A.D. and Kastelein, J.P. and Hayden, M.R.

Modulation of cellular cholesterol efflux in fibroblasts by cAMP: Evidence of post-transcriptional regulation and phosphorylation of ABCA1 protein

Circulation

Haidar, B. and Denis, M. and Marcil, M. and Wellington, C. and Kastelein, J. and Hayden, M. and Genest, J.

Maternal expression of functional lipoprotein lipase and effects on body fat mass and body condition scores of mature cats with lipoprotein lipase deficiency

American Journal of Veterinary Research

Backus, R.C. and Ginzinger, D.G. and Ashbourne Excoffon, K.J.D. and Clee, S.M. and Hayden, M.R. and Eckel, R.H. and Hickman, M.A. and Rogers, Q.R.

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

Science

Zuccato, C. and Ciammola, A. and Rigamonti, D. and Leavitt, B.R. and Goffredo, D. and Conti, L. and MacDonald, M.E. and Friedlander, R.M. and Silani, V. and Hayden, M.R. and Timmusk, T. and Sipione, S. and Cattaneo, E.

High incidence rate and absent family histories in one quarter of patients newly diagnosed with Huntington disease in British Columbia

Clinical Genetics

Almqvist, E.W. and Elterman, D.S. and MacLeod, P.M. and Hayden, M.R.

Common variants in the lipoprotein lipase gene play a significant role in the pathogenesis of HDL-C deficiency in men with coronary heart disease

Arteriosclerosis Thrombosis and Vascular Biology

Brousseau, ME and Goldkamp, AL and Collins, D and Connelly, A and Ordovas, JM and Hayden, MR and Robins, SJ and Rubins, HB and Schaefer, EJ

Common mutations in the lipoprotein lipase gene (LPL): Effects on HDL-cholesterol levels in a Chinese Canadian population

Atherosclerosis

McGladdery, S.H. and Pimstone, S.N. and Clee, S.M. and Bowden, J.Francois and Hayden, M.R. and Frohlich, J.J.

Increased HDL-C and apoA1 dependent efflux modulated by LXREs in human ABCA1 BAC transgenic mice

Circulation

Singaraja, R and Bocher, V and James, ER and Clee, SM and Zhang, LH and Brooks-Wilson, A and Kwok, A and Bissada, N and Yang, YZ and Liu, GQ and Wellington, CL and Fievet, C and Staels, B and Hayden, MR

Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron

Journal of Biological Chemistry

Singaraja, R.R. and Bocher, V. and James, E.R. and Clee, S.M. and Zhang, L.-H. and Leavitt, B.R. and Tan, B. and Brooks-Wilson, A. and Kwok, A. and Bissada, N. and Yang, Y.-Z. and Liu, G. and Tafuri, S.R. and Fievet, C. and Wellington, C.L. and Staels, B. and Hayden, M.R.

Familial influence on age of onset among siblings with huntington disease

American Journal of Medical Genetics - Neuropsychiatric Genetics

Rosenblatt, A. and Brinkman, R.R. and Liang, K.Y. and Almqvist, E.W. and Margolis, R.L. and Huang, C.Y. and Sherr, M. and Franz, M.L. and Abbott, M.H. and Hayden, M.R. and Ross, C.A.

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

Proceedings of the National Academy of Sciences of the United States of America

Parker, J.A. and Connolly, J.B. and Wellington, C. and Hayden, M. and Dausset, J. and Neri, C.

Erratum: A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 (Nature Genetics (2001) 29 (166-173))

Nature Genetics

Hadano, S. and Hand, C.K. and Osuga, H. and Yanagisawa, Y. and Otomo, A. and Devon, R.S. and Miyamoto, N. and Showguchi-Miyata, J. and Okada, Y. and Singaraja, R. and Figlewicz, D.A. and Kwiatkowski, T. and Hosler, B.A. and Sagie, T. and Skaug, J. and Nasir, J. and Brown R.H., Jr. and Scherer, S.W. and Rouleau, G.A. and Hayden, M.R. and Ikeda, J.-E.

ABCA1 regulatory variants influence coronary artery disease (CAD) independent of effects on plasma lipid levels.

Circulation

Clee, SM and Zwarts, KY and Zwinderman, AH and Engert, JC and Singaraja, R and Loubser, O and James, ER and Roomp, K and Hudson, TJ and Jukema, JW and Kastelein, JJP and Hayden, MR

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 (vol 29, pg 166, 2001)

Nature Genetics

Hadano, S. and Hand, C. K. and Osuga, H. and Yanagisawa, Y. and Otomo, A. and Devon, R. S. and Miyamoto, N. and Showguchi-Miyata, J. and Okada, Y. and Singaraja, R. and Figlewicz, D. A. and Kwiatkowski, T. and Hosler, B. A. and Sagie, T. and Skaug, J. and Nasir, J. and Brown, R. H. and Scherer, S. W. and Rouleau, G. A. and Hayden, M. R. and Ikeda, J. E.

Wild-type Huntingtin reduces the cellular toxicity of mutant Huntingtin in vivo

American Journal of Human Genetics

Leavitt, B.R. and Guttman, J.A. and Hodgson, J.G. and Kimel, G.H. and Singaraja, R. and Vogl, A.W. and Hayden, M.R.

The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease

Clinical Genetics

Clee, S.M. and Loubser, O. and Collins, J. and Kastelein, J.J.P. and Hayden, M.R.

The factor structure for positive and negative symptoms in South African Xhosa patients with schizophrenia

Schizophrenia Research

Emsley, R.A. and Niehaus, D.J.H. and Mbanga, N.I. and Oosthuizen, P.P. and Stein, D.J. and Maritz, J.S. and Pimstone, S.N. and Hayden, M.R. and Laurent, C. and Deleuze, J.-F. and Mallet, J.

The 'flap' endonuclease gene FEN1 is excluded as a candidate gene implicated in the CAG repeat expansion underlying Huntington disease

Clinical Genetics

Otto, C.J. and Almqvist, E. and Hayden, M. and Andrew, S.E.

NMDA receptor function in mouse models of Huntington disease

Journal of Neuroscience Research

Cepeda, C. and Ariano, M.A. and Calvert, C.R. and Flores-Hernndez, J. and Chandler B, S.H. and Leavitt, B.R. and Hayden, M.R. and Levine, M.S.

Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's diseases (HD) transcripts and is activated in HD tissue

Human Molecular Genetics

Peel, A.L. and Rao, R.V. and Cottrell, B.A. and Hayden, M.R. and Ellerby, L.M. and Bredesen, D.E.

Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue

Human Molecular Genetics

Peel, AL and Rao, RV and Cottrell, BA and Hayden, MR and Ellerby, LM and Bredesen, DE

Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease

Circulation

Clee, S.M. and Zwinderman, A.H. and Engert, J.C. and Zwarts, K.Y. and Molhuizen, H.O.F. and Roomp, K. and Jukema, J.W. and Van Wijland, M. and Van Dam, M. and Hudson, T.J. and Brooks-Wilson, A. and Genest Jr., J. and Kastelein, J.J.P. and Hayden, M.R.

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

Nature Genetics

Hadano, S. and Hand, C.K. and Osuga, H. and Yanagisawa, Y. and Otomo, A. and Devon, R.S. and Miyamoto, N. and Showguchi-Miyata, J. and Okada, Y. and Singaraja, R. and Figlewicz, D.A. and Kwiatkowski, T. and Hosler, B.A. and Sagie, T. and Skaug, J. and Nasir, J. and Brown, R.H. and Scherer, S.W. and Rouleau, G.A. and Hayden, M.R. and Ikeda, J.-E.

HIP1 Functions in Clathrin-mediated Endocytosis through Binding to Clathrin and Adaptor Protein 2

Journal of Biological Chemistry

Metzler, M. and Legendre-Guillemin, V. and Gan, L. and Chopra, V. and Kwok, A. and McPherson, P.S. and Hayden, M.R.

Erratum: A one-hit model of cell death in inherited neuronal degenerations (Nature (2000) 406 (195-199))

Nature

Clarke, G. and Collins, R.A. and Leavitt, B.R. and Andrews, D.F. and Hayden, M.R. and Lumsden, C.J. and McInnes, R.R.

Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: Candidate genes for ALS2

Genomics

Hadano, S. and Yanagisawa, Y. and Skaug, J. and Fichter, K. and Nasir, J. and Martindale, D. and Koop, B.F. and Scherer, S.W. and Nicholson, D.W. and Rouleau, G.A. and Ikeda, J.-E. and Hayden, M.R.

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

Proceedings of the National Academy of Sciences of the United States of America

Holbert, S. and Denghien, I. and Kiechle, T. and Rosenblatt, A. and Wellington, C. and Hayden, M.R. and Margolis, R.L. and Ross, C.A. and Dausset, J. and Ferrante, R.J. and Nri, C.

Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases

American Journal of Human Genetics

Falush, D. and Almqvist, E.W. and Brinkmann, R.R. and Iwasa, Y. and Hayden, M.R.

Truncation mutations in human ABCA1 suppress normal upregulation of wild-type ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

Circulation

Wellington, CL and Yang, YZ and Kwok, A and Clee, SM and Zwartz, K and Marcel, M and Newman, S and Roomp, K and Singaraja, R and Zhang, LH and Kastelein, JJP and Genest, J and Hayden, MR

Mutant huntingtin enhances excitotoxic cell death

Molecular and Cellular Neuroscience

Zeron, M.M. and Chen, N. and Moshaver, A. and Ting-Chun Lee, A. and Wellington, C.L. and Hayden, M.R. and Raymond, L.A.

HIP1(-/-) mice develop a adult onset phenotype characterized by thoracolumbar kyphosis, alterations in synaptic plasticity and a defect in reproduction

Molecular Biology of the Cell

Metzler, MM and Georgiou, J and Gutekunst, CA and Oh, R and Gan, L and Rich, M and Roder, J and Hayden, MR

cSNP analysis of the ABCA1 gene: the R219K variant is associated with a blunted age-modulated increase in HDL cholesterol and decreased coronary artery disease (CAD).

American Journal of Human Genetics

Molhuizen, HOF and Clee, SM and Zwinderman, AH and Engert, J and Zwarts, KY and Roomp, K and Brooks-Wilson, A and Hudson, T and Jukema, JW and Kastelein, JJP and Hayden, MR

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency,Mutations du gene de l'ATP binding cassette-1 (ABC1) dans la maladie de Tangier et la deficience familiale en HDL

Medecine/Sciences

Marcil, M. and Genest Jr., J. and Brooks-Wilson, A. and Hayden, M. and Kastelein, J.

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

Journal of Biological Chemistry

Hackam, A.S. and Yassa, A.S. and Singaraja, R. and Metzler, M. and Gutekunst, C.-A. and Gan, L. and Warby, S. and Wellington, C.L. and Vaillancourt, J. and Chen, N. and Gervais, F.G. and Raymond, L. and Nicholson, D.W. and Hayden, M.R.

Caspases and neurodegeneration: On the cutting edge of new therapeutic approaches

Clinical Genetics

Wellington, C.L. and Hayden, M.R.

Wild-type huntingtin protects from apoptosis upstream of caspase-3

Journal of Neuroscience

Rigamonti, D. and Bauer, J.H. and De-Fraja, C. and Conti, L. and Sipione, S. and Sciorati, C. and Clementi, E. and Hackam, A. and Hayden, M.R. and Li, Y. and Cooper, J.K. and Ross, C.A. and Govoni, S. and Vincenz, C. and Cattaneo, E.

The modulation of HIP1 function through its interaction with its family member HIP12: implications for the pathogenesis of Huntington disease

American Journal of Human Genetics

Chopra, V. and Metzler, M. and Rasper, D. and Singaraja, R. and Gan, L. and Nicholson, D. and Hayden, M.

Mutations in ABC1 in Tangier disease and familiar high-density lipoprotein deficiency

M S-Medecine Sciences

Marcil, M. and Brooks-Wilson, A. and Kastelein, J. and Hayden, M. and Genest, J.

Huntingtin interacting protein 1 knockout mice are viable and provide insights into the developmental expression of HIP1

Molecular Biology of the Cell

Metzler, MM and Gan, L and Oh, R and Gertsenstein, M and Borowski, A and Jirik, FR and Nagy, A and Hayden, MR

Huntingtin interacting protein 1 knock-out mice are viable and provide insights into the developmental expression of HIP1.

American Journal of Human Genetics

Metzler, MM and Gan, L and Oh, R and Gertsenstein, M and Hackam, AS and Borowski, A and Jirik, FR and Nagy, A and Hayden, MR

Phenotypic correction of feline lipoprotein lipase deficiency by adenoviral gene transfer

Human Gene Therapy

Liu, G. and Ashbourne Excoffon, K.J.D. and Wilson, J.E. and McManus, B.M. and Rogers, Q.R. and Miao, L. and Kastelein, J.J.P. and Lewis, M.E.S. and Hayden, M.R.

Massive cholesterol ester accumulation in hepatocytes and intestinal epithelial cells caused by ABC1 mutation in WHAM chickens

Circulation

Attie, AD and Brooks-Wilson, A and Gray-Keller, ME and Zhang, LH and Tebon, A and Mulligan, J and Bitgood, JJ and Cook, ME and Kastelein, JJP and Hayden, MR

Human huntingtin-associated protein (HAP-1) gene: Genomic organisation and an intragenic polymorphism

Gene

Nasir, J. and Lafuente, M.-J. and Duan, K. and Colomer, V. and Engelender, S. and Ingersoll, R. and Margolis, R.L. and Ross, C.A. and Hayden, M.R.

A one-hit model of cell death in inherited neuronal degenerations

Nature

Clarke, G. and Collins, R.A. and Leavitt, B.R. and Andrews, D.F. and Hayden, M.R. and Lumsden, C.J. and McInnes, R.R.

Huntington disease: New insights on the role of huntingtin cleavage

Journal of Neural Transmission, Supplement

Wellington, C.L. and Leavitt, B.R. and Hayden, M.R.

Familial aggregation of psychotic symptoms in Huntington's disease

American Journal of Psychiatry

Tsuang, D. and Almqvist, E.W. and Lipe, H. and Strgar, F. and DiGiacomo, L. and Hoff, D. and Eugenio, C. and Hayden, M.R. and Bird, T.D.

Defects in cellular cholesterol efflux are frequent cause of HDL deficiency

Circulation

Bissonnette, R and Marcil, M and Molhuizen, HO and Brooks-Wilson, A and Collins, J and Boucher, B and Groen, BK and Roomp, K and Wijland, MJA and Hayden, MR and Kastelein, J and Genest, J

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes

Journal of Clinical Investigation

Clee, S.M. and Kastelein, J.J.P. and Van Dam, M. and Marcil, M. and Roomp, K. and Zwarts, K.Y. and Collins, J.A. and Roelants, R. and Tamasawa, N. and Stulc, T. and Suda, T. and Ceska, R. and Boucher, B. and Rondeau, C. and DeSouich, C. and Brooks-Wilson, A. and Molhuizen, H.O.F. and Frohlich, J. and Genest Jr., J. and Hayden, M.R.

Accelerating the natural history of neurodegeneration in Huntington disease YAC transgenic mice: Facilitation of in vivo screening of potential therapeutic agents.

American Journal of Human Genetics

Leavitt, BR and Gutekunst, CA and Oh, R and Chan, E and Bissada, N and Hersch, S and Hayden, MR

The age modulated phenotype in heterozygotes for mutations in ABC1 includes significantly decreased HDL, increased triglycerides and an increased frequency of coronary artery disease (CAD).

Circulation

Clee, SM and Zwarts, KY and Roomp, K and Collins, JA and Van Dam, M and Marcil, M and Brooks-Wilson, A and Genest, J and Kastelein, JJP and Hayden, MR

Michael smith (1932-2000)

Nature

Hayden, M.R. and Ling, V.

Huntingtin is required for normal hematopoiesis

Human Molecular Genetics

Metzler, M. and Helgason, C.D. and Dragatsis, I. and Zhang, T. and Gan, L. and Pineault, N. and Zeitlin, S.O. and Humphries, R.K. and Hayden, M.R.

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

Journal of Biological Chemistry

Wellington, C.L. and Singaraja, R. and Ellerby, L. and Savill, J. and Roy, S. and Leavitt, B. and Cattaneo, E. and Hackam, A. and Sharp, A. and Thornberry, N. and Nicholson, D.W. and Bredesen, D.E. and Hayden, M.R.

CSNPs within the ABC1 gene influence HDL cholesterol levels and risk of coronary artery disease (CAD)

Circulation

Clee, SM and Molhuizen, HO and Zwinderman, AH and Engert, JC and Roomp, K and Zwarts, KY and Jukema, JW and Hudson, TJ and Brooks-Wilson, A and Kastelein, JJP and Hayden, MR

Cholesterol efflux regulatory protein, Tangier disease and familial high density lipoprotein deficiency

Current Opinion in Lipidology

Hayden, M.R. and Clee, S.M. and Brooks-Wilson, A. and Genest Jr., J. and Attie, A. and Kastelein, J.J.P.

Predictive testing for Huntington's disease: The calm after the storm

Lancet

Hayden, M.R.

Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis

Journal of Lipid Research

Clee, S.M. and Bissada, N. and Miao, F. and Miao, L. and Marais, A.D. and Henderson, H.E. and Steures, P. and McManus, J. and McManus, B. and LeBoeuf, R.C. and Kastelein, J.J.P. and Hayden, M.R.

Identification of 20 full-length transcripts in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: Candidate genes for ALS2.

American Journal of Human Genetics

Hadano, S and Yanagisawa, Y and Skaug, J and Fichter, K and Scherer, SW and Rouleau, GA and Hayden, MR and Ikeda, JE

HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin

Mammalian Genome

Chopra, V.S. and Metzler, M. and Rasper, D.M. and Engqvist-Goldstein, A.E.Y. and Singaraja, R. and Gan, L. and Fichter, K.M. and McCutcheon, K. and Drubin, D. and Nicholson, D.W. and Hayden, M.R.

HDL levels in ABCA1 heterozygotes are predicted by cholesterol efflux levels and are influenced by age.

American Journal of Human Genetics

Clee, SM and Zwarts, KY and Roomp, K and Collins, JA and Marcil, M and van Dam, M and Brooks-Wilson, A and Genest, J and Kastelein, JJP and Hayden, MR

Recent insights into the molecular pathogenesis of Huntington disease (vol 19, pg 385, 1999)

Seminars in Neurology

Leavitt, BR and Wellington, CL and Hayden, MR

Lipoprotein lipase activity is associated with severity of angina pectoris

Circulation

Kastelein, J.J.P. and Jukema, J.W. and Zwinderman, A.H. and Clee, S. and Van Boven, A.J. and Jansen, H. and Rabelink, T.J. and Peters, R.J.G. and Lie, K.I. and Liu, G. and Bruschke, A.V.G. and Hayden, M.R.

From molecular accomplices to pathways in the pathogenesis of HD: The roles of novel DED containing interacting proteins, HIP1 and Hippi

American Journal of Human Genetics

Singaraja, R. and Gervais, F. and Hackam, A. and Xanthoudakis, S. and Houtzager, V. and Rasper, D. and Roy, S. and Leavitt, B. and Gutekunst, C. A. and Hayden, M. and Nicholson, D.

A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease

American Journal of Human Genetics

Almqvist, E.W. and Bloch, M. and Brinkman, R. and Craufurd, D. and Hayden, M.R.

Neuronal degeneration in the basal ganglia and loss of pallido- subthalamic synapses in mice with targeted disruption of the Huntington's disease gene

Brain Research

O'Kusky, J.R. and Nasir, J. and Cicchetti, F. and Parent, A. and Hayden, M.R.

Influence of lamotrigine on progression of early Huntington disease: A randomized clinical trial

Neurology

Kremer, B. and Clark, C.M. and Almqvist, E.W. and Raymond, L.A. and Graf, P. and Jacova, C. and Mezei, M. and Hardy, M.A. and Snow, B. and Martin, W. and Hayden, M.R.

Effect of concurrent LDL receptor gene and LPL gene mutations on LDL particles size, density and lipid composition

Atherosclerosis

Zambon, A and Gagne, C and Lupien, PJ and Moorjani, S and Hayden, MR and Brunzell, JD

A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: The Framingham Offspring Study

Clinical Genetics

Gagn, S.E. and Larson, M.G. and Pimstone, S.N. and Schaefer, E.J. and Kastelein, J.J.P. and Wilson, P.W.F. and Ordovas, J.M. and Hayden, M.R.

The actin cytoskeleton and endocytosis linked by the Huntingtin Interacting Protein 1 Related (Hip1R), a protein belonging to the Sla2/Hip1 family.

Molecular Biology of the Cell

Engqvist-Goldstein, AEY and Kessels, MM and Chopra, VS and Hayden, MR and Drubin, DG

Lipid and lipoprotein analysis of cats with lipoprotein lipase deficiency

European Journal of Clinical Investigation

Ginzinger, D.G. and Clee, S.M. and Dallongeville, J. and Lewis, M.E.S. and Henderson, H.E. and Bauje, E. and Rogers, Q.R. and Jensen, D.R. and Eckel, R.H. and Dyer, R. and Innis, S. and Jones, B. and Fruchart, J.-C. and Hayden, M.R.

Inhibition of caspase cleavage of huntingtin protects neurons from toxicity and aggregate formation.

American Journal of Human Genetics

Wellington, CL and Singaraja, R and Ellerby, L and Savill, J and Roy, S and Leavitt, B and Cattaneo, E and Hackam, A and Sharp, A and Thornberry, N and Bredesen, D and Nicholson, D and Hayden, MR

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

Nature Genetics

Brooks-Wilson, A. and Marcil, M. and Clee, S.M. and Zhang, L.-H. and Roomp, K. and Van Dam, M. and Yu, L. and Brewer, C. and Collins, J.A. and Molhuizen, H.O.F. and Loubser, O. and Ouelette, B.F.F. and Fichter, K. and Ashbourne-Excoffon, K.J.D. and Sensen, C.W. and Scherer, S. and Mott, S. and Denis, M. and Martindale, D. and Frohlich, J. and Morgan, K. and Koop, B. and Pimstone, S. and Kastelein, J.J.P. and Genest Jr., J. and Hayden, M.R.

Life without Huntington: Normal differentiation into functional neurons

Journal of Neurochemistry

Metzler, M. and Chen, N. and Helgason, C.D. and Graham, R.K. and Nichol, K. and McCutcheon, K. and Nasir, J. and Humphries, R.K. and Raymond, L.A. and Hayden, M.R.

Influence of lamotrigine on progression of early Huntington disease - A randomized clinical trial

Neurology

Kremer, B and Clark, CM and Almqvist, EW and Raymond, LA and Graf, P and Jacova, C and Mezei, M and Hardy, MA and Snow, B and Martin, W and Hayden, MR

Genomic organization of the human caspase-9 gene on Chromosome 1p36.1- p36.3

Mammalian Genome

Hadano, S. and Nasir, J. and Nichol, K. and Rasper, D.M. and Vaillancourt, J.P. and Sherer, S.W. and Beatty, B.G. and Ikeda, J.-E. and Nicholson, D.W. and Hayden, M.R.

A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Wittekoek, M.E. and Moll, E. and Pimstone, S.N. and Trip, M.D. and Lansberg, P.J. and Defesche, J.C. and Van Doormaal, J.J. and Hayden, M.R. and Kastelein, J.J.P.

Huntingtin interacting protein-1 (HIP-1) associated neuronal death is accompanied by activation of the caspase and JNK pathways.

American Journal of Human Genetics

Hackam, AS and Yassa, AS and Vaillancourt, J and Metzler, M and Gan, L and Nicholson, DW and Hayden, MR

Allelic but not genetic heterogeneity underlies Tangier disease

Circulation

Brooks-Wilson, AR and Genest, JJ and van Dam, MJ and Marcil, M and Brewer, C and Mott, S and Morgan, K and Hayden, MR and Kastelein, JJP

Recent insights into the molecular pathogenesis of Huntington disease

Seminars in Neurology

Leavitt, B.R. and Wellington, C.L. and Hayden, M.R.

Phenotypic correction of feline lipoprotein lipase (LPL) deficiency by adenoviral gene transfer.

American Journal of Human Genetics

Liu, G and Exocoffon, KJDA and Wilson, JE and McManus, BM and Miao, L and Lewis, MES and Hayden, MR

Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux

Lancet

Marcil, M. and Brooks-Wilson, A. and Clee, S.M. and Roomp, K. and Zhang, L.-H. and Yu, L. and Collins, J.A. and Van Dam, M. and Molhuizen, H.O.F. and Loubster, O. and Ouellette, B.F.F. and Sensen, C.W. and Fichter, K. and Mott, S. and Denis, M. and Boucher, B. and Pimstone, S. and Genest Jr., J. and Kastelein, J.J.P. and Hayden, M.R.

Endogenous huntingtin modulates the cellular toxicity of mutant huntingtin.

American Journal of Human Genetics

Leavitt, BR and Hackam, A and Gutekunst, CA and McCutcheon, K and Yassa, A and Singaraja, R and Kimel, G and Hersch, S and Vogl, W and Hayden, MR

A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

Genomics

Hadano, S. and Nichol, K. and Brinkman, R.R. and Nasir, J. and Martindale, D. and Koop, B.F. and Nicholson, D.W. and Scherer, S.W. and Ikeda, J.-E. and Hayden, M.R.

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

Journal of Neurochemistry

Chen, N. and Luo, T. and Wellington, C. and Metzler, M. and McCutcheon, K. and Hayden, M.R. and Raymond, L.A.

Mutations in transportin (ABC1) in Tangier disease and familial HDL deficiency.

American Journal of Human Genetics

Brooks-Wilson, AR and Marcil, M and Clee, SM and Zhang, LH and Roomp, K and van Dam, MJ and Yu, L and Brewer, C and Collins, JA and Molhuizen, HOF and Ouellette, BFF and Sensen, CW and Martindale, D and Frohlich, J and Morgan, K and Koop, B and Pimstone, S and Kastelein, JJP and Genest, J and Hayden, MR

Kennedy's disease: Caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

Journal of Neurochemistry

Ellerby, L.M. and Hackam, A.S. and Propp, S.S. and Ellerby, H.M. and Rabizadeh, S. and Cashman, N.R. and Trifiro, M.A. and Pinsky, L. and Wellington, C.L. and Salvesen, G.S. and Hayden, M.R. and Bredesen, D.E.

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease

Human Molecular Genetics

Hackam, A.S. and Singaraja, R. and Zhang, T. and Gan, L. and Hayden, M.R.

Effects of wild-type or mutant Huntingtin in striatal cells.

American Journal of Human Genetics

Bauer, JH and Rigamonti, D and De-Fraja, C and Conti, L and Sipione, S and Sciorati, C and Clementi, E and Hackam, A and Hayden, MR and Li, Y and Cooper, JK and Ross, CA and Vincenz, C and Cattaneo, E

An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles

Journal of Cell Biology

Engqvist-Goldstein, ?.E.Y. and Kessels, M.M. and Chopra, V.S. and Hayden, M.R. and Drubin, D.G.

Two common mutations (D9N, N291S) in lipoprotein lipase: A cumulative analysis of their influence on plasma lipids and lipoproteins in men and women

Clinical Genetics

Kastelein, J.J.P. and Ordovas, J.M. and Wittekoek, M.E. and Pimstone, S.N. and Wilson, P.W.F. and Gagn, S.E. and Larson, M.G. and Schaefer, E.J. and Boer, J.M.A. and Gerdes, C. and Hayden, M.R.

The lipoprotein lipase S447X variant is associated with decreased systolic and diastolic blood pressure

Circulation

Clee, SM and Loubser, O and Collins, J and Kastelein, JJ and Hayden, MR

Genomic organization of the human caspase-9 gene on Chromosome 1p36.1-p36.3

Mammalian Genome

Hadano, S and Nasir, J and Nichol, K and Rasper, DM and Vaillancourt, JP and Sherer, SW and Beatty, BG and Ikeda, JE and Nicholson, DW and Hayden, MR

Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin

Neuroscience

Kim, M. and Velier, J. and Chase, K. and Laforet, G. and Kalchman, M.A. and Hayden, M.R. and Won, L. and Heller, A. and Aronin, N. and Difiglia, M.

Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin

Philosophical Transactions of the Royal Society B: Biological Sciences

Hackam, A.S. and Hodgson, J.G. and Singaraja, R. and Zhang, T. and Gan, L. and Gutekunst, C.-A. and Hersch, S.M. and Hayden, M.R.

Disturbed interaction between Huntingtin and HIP3 implicates defects in neuronal endocytosis in the pathogenesis of HD.

American Journal of Human Genetics

Singaraja, RR and Hadano, S and Metzier, M and Wellington, C and Leavitt, B and Baich, W and Bannykh, S and Fichter, K and Hackam, A and Gan, L and Zhang, T and Yassa, A and McCutcheon, K and Michel, JML and Chopra, V and Sherer, S and Geitz, D and Hayden, MR

Chromosomal localization of the Huntingtin Associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping

Mammalian Genome

Nasir, J. and Maclean, A. and Engelender, S. and Duan, K. and Margolis, R.L. and Kleiderlein, J.J. and Ross, C.A. and Hayden, M.R.

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration

Neuron

Hodgson, J.G. and Agopyan, N. and Gutekunst, C.-A. and Leavitt, B.R. and Lepiane, F. and Singaraja, R. and Smith, D.J. and Bissada, N. and McCutcheon, K. and Nasir, J. and Jamot, L. and Xiao-Jiang, L. and Stevens, M.E. and Rosemond, E. and Roder, J.C. and Phillips, A.G. and Rubin, E.M. and Hersch, S.M. and Hayden, M.R.

A transcript map of the ALS2 candidate locus on human chromosome 2q33-q34, and exclusion of usurpin, caspase-10, and caspase-8 as candidate genes for ALS2.ALS2.

American Journal of Human Genetics

Hadano, S and Nichol, N and Fichter, K and Huizenga, J and Skaug, J and Nasir, J and Martindale, D and Koop, BF and Nicholson, DW and Scherer, SW and Rouleau, GA and Ikeda, JE and Hayden, MR

Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins

Journal of Lipid Research

Henderson, H.E. and Kastelein, J.J.P. and Zwinderman, A.H. and Gagn, E. and Jukema, J.W. and Reymer, P.W.A. and Groenemeyer, B.E. and Lie, K.I. and Bruschke, A.V.G. and Hayden, M.R. and Jansen, H.

Hereditary syringomyelia: A manifestation of familial vascular malformations?

Neurology

Spacey, SD and Ramsay, DA and Hayden, MR

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

Journal of Biological Chemistry

Ellerby, L.M. and Andrusiak, R.L. and Wellington, C.L. and Hackam, A.S. and Propp, S.S. and Wood, J.D. and Sharp, A.H. and Margolis, R.L. and Ross, C.A. and Salvesen, G.S. and Hayden, M.R. and Bredesen, D.E.

Accurate determination of the number of CAG repeats in the Huntington disease gene using a sequence-specific internal DNA standard

Clinical Genetics

Bruland, O. and Almqvist, E.W. and Goldberg, Y.P. and Boman, H. and Hayden, M.R. and Knappskog, P.M.

Ile225Thr loop mutation in the Lipoprotein Lipase (LPL) gene is a de novo event

American Journal of Medical Genetics

Henderson, H.E. and Bijvoet, S.M. and Mannens, M.A.M.M. and Bruin, T. and Erkelens, D.W. and Hayden, M.R. and Kastelein, J.J.P.

Phenotypic variation in heterozygous familial hypercholesterolemia: A comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada

Arteriosclerosis, Thrombosis, and Vascular Biology

Pimstone, S.N. and Sun, X.-M. and Du Souich, C. and Frohlich, J.J. and Hayden, M.R. and Soutar, A.K.

In vitro and in vivo models for Huntington disease: Lessons for the polyglutamine expansion disorders,Modeles in vitro et in vivo de la maladie de Huntington: Enseignements pour les pathologies liees a des expansions de polyglutamine

Pathologie Biologie

Hayden, M.R.

Compound heterozygosity for frameshift mutations in the gene for lipoprotein lipase in a patient with early onset chylomicronemia

Human Mutation

Foubert, L. and Gennes, J.L.D. and Benlian, P. and Truffert, J. and Miao, L. and Hayden, M.R.

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

Cell Death and Differentiation

Rasper, D.M. and Vaillancourt, J.P. and Hadano, S. and Houtzager, V.M. and Seiden, I. and Keen, S.L.C. and Tawa, P. and Xanthoudakis, S. and Nasir, J. and Martindale, D. and Koop, B.F. and Peterson, E.P. and Thornberry, N.A. and Huang, J. and MacPherson, D.P. and Black, S.C. and Hornung, F. and Lenardo, M.J. and Hayden, M.R. and Roy, S. and Nicholson, D.W.

A novel Glu421Lys substitution in the lipoprotein lipase gene in pregnancy-induced hypertriglyceridemic pancreatitis

Clinica Chimica Acta

Henderson, H. and Leisegang, F. and Hassan, F. and Hayden, M. and Marais, D.

Common variants of lipoprotein lipase (LPL) strongly influence levels of lipids and lipoproteins and coronary artery disease (CAD) in patients with familial hypercholesterolemia (FH)

Circulation

Kastelein, JJP and Wittekoek, ME and Loubser, O and Clee, SM and Collins, J and Moll, E and Pimstone, SN and Hayden, MR

The new clinical genetics: Towards the millennium

Clinical Genetics

Hayden, M.R.

Lipoprotein lipase (LPL) activity is decreased in CAD patients and inversely correlated with severity of angina pectoris and silent myocardial ischemia

Circulation

Kastelein, JJP and Jukema, JW and van Boven, AJ and Jansen, H and Zwinderman, AH and Rabelink, TJ and Peters, RJG and Lie, KI and Bruschke, AVG and Hayden, MR

A mouse protein related to yeast Sla2/end4 and human huntingtin-interacting protein may link the actin cytoskeleton to membrane dynamics

Molecular Biology of the Cell

Engqvist-Goldstein, A and Lila, T and Kalchman, MA and Chopra, V and Hayden, MR and Drubin, DG

The fatal attraction of polyglutamine-containing proteins

Clinical Genetics

Hackam, A.S. and Wellington, C.L. and Hayden, M.R.

Gene structure and map location of the murine homolog of the Huntington- associated protein, Hap1

Mammalian Genome

Nasir, J. and Duan, K. and Nichol, K. and Engelender, S. and Ashworth, R. and Colomer, V. and Thomas, S. and Disteche, C.M. and Hayden, M.R. and Ross, C.A.

Dyslipidemias associated with heterozygous lipoprotein lipase mutations in the French-Canadian population

Human Mutation

Julien, P. and Gagn, C. and Murthy, M.R.V. and Lvesque, G. and Moorjani, S. and Cadelis, F. and Hayden, M.R. and Lupien, P.J.

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

Journal of Biological Chemistry

Wellington, C.L. and Ellerby, L.M. and Hackam, A.S. and Margolis, R.L. and Trifiro, M.A. and Singaraja, R. and McCutcheon, K. and Salvesen, G.S. and Propp, S.S. and Bromm, M. and Rowland, K.J. and Zhang, T. and Rasper, D. and Roy, S. and Thornberry, N. and Pinsky, L. and Kakizuka, A. and Ross, C.A. and Nicholson, D.W. and Bredesen, D.E. and Hayden, M.R.

The influence of huntingtin protein size on nuclear localization and cellular toxicity

Journal of Cell Biology

Hackam, A.S. and Singaraja, R. and Wellington, C.L. and Metzler, M. and McCutcheon, K. and Zhang, T. and Kalchman, M. and Hayden, M.R.

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

Nature Genetics

Martindale, D. and Hackam, A. and Wieczorek, A. and Ellerby, L. and Wellington, C. and McCutcheon, K. and Singaraja, R. and Kazemi-Esfarjani, P. and Devon, R. and Kim, S.U. and Bredesen, D.E. and Tufaro, F. and Hayden, M.R.

Ile(225)Thr loop mutation in the lipoprotein lipase (LPL) gene is a de novo event

American Journal of Medical Genetics

Henderson, HE and Bijvoet, SM and Mannens, MAMM and Bruin, T and Erkelens, DW and Hayden, MR and Kastelein, JJP

Compound heterozygosity for frameshift mutations in the gene for lipoprotein lipase in a patient with early-onset chylomicronemia

Human Mutation

Foubert, L and De Gennes, JL and Benlian, P and Truffert, J and Miao, L and Hayden, MR

Atherogenicity of lipoprotein lipase is related to its site of expression: In vivo evidence of vessel wall versus plasma effects

Circulation

Clee, SM and Bissada, N and Miao, F and Miao, L and Steures, P and Marais, D and McManus, J and McManus, B and Henderson, HE and Hayden, MR

A Huntington disease-like neurodegenerative disorder maps to chromosome 20p

American Journal of Human Genetics

Xiang, F. and Almqvist, E.W. and Huq, M. and Lundin, A. and Hayden, M.R. and Edstrm, L. and Anvret, M. and Zhang, Z.

The Asn9 variant of lipoprotein lipase is associated with the - 93G promoter mutation and an increased risk of coronary artery disease

Clinical Genetics

Kastelein, J.J.P. and Groenemeyer, B.E. and Hallman, D.M. and Henderson, H. and Reymer, P. and Gagn, S.E. and Jansen, H. and Seidell, J.C. and Kromhout, D. and Jukema, J.W. and Bruschke, A.V.G. and Boerwinkle, E. and Hayden, M.R.

Enhanced lipolysis in normal mice expressing liver-derived human lipoprotein lipase after adenoviral gene transfer

Clinical and Investigative Medicine

Liu, G. and Ashbourne Excoffon, K.J.D. and Wilson, J.E. and McManus, B.M. and Miao, L. and Benoit, P. and Duverger, N. and Branellec, D. and Denefle, P. and Hayden, M.R. and Lewis, M.E.S.

A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia

Circulation

Wittekoek, M.E. and Pimstone, S.N. and Reymer, P.W.A. and Feuth, L. and Botma, G.-J. and Defesche, J.C. and Prins, M. and Hayden, M.R. and Kastelein, J.J.P.

Phenotypic variation in heterozygous familial hypercholesterolemia - A comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada

Arteriosclerosis Thrombosis and Vascular Biology

Pimstone, SN and Sun, XM and du Souich, C and Frohlich, JJ and Hayden, MR and Soutar, AK

In vitro and in vivo models for Huntington disease: lessons for the polyglutamine expansion disorders.

Pathologie Biologie

Hayden, MR

Contribution of DNA sequence and CAG size to mutation frequencies of intermediate alleles for Huntington disease: Evidence from single sperm analyses

Human Molecular Genetics

Chong, S.S. and Almqvist, E. and Telenius, H. and LaTray, L. and Nichol, K. and Bourdelat-Parks, B. and Goldberg, Y.P. and Haddad, B.R. and Richards, F. and Sillence, D. and Greenberg, C.R. and Ives, E. and Van Den Engh, G. and Hughes, M.R. and Hayden, M.R.

Toward understanding the molecular pathology of huntington's disease

Brain Pathology

Wellington, C.L. and Brinkman, R.R. and O'Kusky, J.R. and Hayden, M.R.

The likelihood of being affected with huntington disease by a particular age, for a specific CAG size

American Journal of Human Genetics

Brinkman, R.R. and Mezei, M.M. and Theilmann, J. and Almqvist, E. and Hayden, M.R.

Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: Modulation by cholesteryl ester transfer protein and dietary status

Journal of Lipid Research

Clee, S.M. and Zhang, H. and Bissada, N. and Miao, L. and Ehrenborg, E. and Benlian, P. and Shen, G.X. and Angel, A. and LeBoeuf, R.C. and Hayden, M.R.

Premature atherosclerosis in familial chylomicronemia - Reply

New England Journal of Medicine

Benlian, P and Hayden, MR

Development of an in vitro model for Huntington's disease: Evidence that the N-terminal domain of huntingtin is toxic to cells.

American Journal of Human Genetics

Hackam, AS and Ellerby, LM and Wellington, CL and Bredesen, DE and Hayden, MR

Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase - Deficient mice by adenovirus-mediated expression of human lipoprotein lipase

Arteriosclerosis, Thrombosis, and Vascular Biology

Ashbourne Excoffon, K.J.D. and Liu, G. and Miao, L. and Wilson, J.E. and McManus, B.M. and Semenkovich, C.F. and Coleman, T. and Benoit, P. and Duverger, N. and Branellec, D. and Denefle, P. and Hayden, M.R. and Lewis, M.E.S.

Localization of the cell death genes CPP32 and Mch-2 to human Chromosome 4q

Mammalian Genome

Nasir, J. and Theilmann, J.L. and Chopra, V. and Jones, A.M. and Walker, D. and Rasper, D.M. and Vaillancourt, J.P. and Hewitt, J.E. and Nicholson, D.W. and Hayden, M.R.

Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells

Human Gene Therapy

Liu, G. and Ashbourne Excoffon, K.J.D. and Benoit, P. and Ginzinger, D.G. and Miao, L. and Ehrenborg, E. and Duverger, N. and Denefle, P.P. and Hayden, M.R. and Lewis, M.E.S.

Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer

American Journal of Human Genetics

Goellner, G.M. and Tester, D. and Thibodeau, S. and Almqvist, E. and Goldberg, Y.P. and Hayden, M.R. and McMurray, C.T.

Ethnic variation and in vivo effects of the -93tg promoter variant in the lipoprotein lipase gene

Arteriosclerosis, Thrombosis, and Vascular Biology

Ehrenborg, E. and Clee, S.M. and Pimstone, S.N. and Reymer, P.W.A. and Benlian, P. and Hoogendijk, C.F. and Davis, H.J. and Bissada, N. and Miao, L. and Gagn, S.E. and Greenberg, L.J. and Henry, R. and Henderson, H. and Ordovas, J.M. and Schaefer, E.J. and Kastelein, J.J.P. and Kotze, M.J. and Hayden, M.R.

Differences in the phenotype between children with familial defective apolipoprotein B-100 and familial hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Pimstone, S.N. and Defesche, J.C. and Clee, S.M. and Bakker, H.D. and Hayden, M.R. and Kastelein, J.J.P.

Diet-induced atherosclerosis in the domestic cat

Laboratory Investigation

Ginzinger, D.G. and Wilson, J.E. and Redenbach, D. and Lewis, M.E.S. and Clee, S.M. and Ashbourne Excoffon, K.J.D. and Rogers, Q.R. and Hayden, M.R. and McManus, B.M.

Risk reversals in predictive testing for Huntington disease

American Journal of Human Genetics

Almqvist, E. and Adam, S. and Bloch, M. and Fuller, A. and Welch, P. and Eisenberg, D. and Whelan, D. and Macgregor, D. and Meschino, W. and Hayden, M.R.

Rethinking genotype and phenotype correlations in polyglutamine expansion disorders

Human Molecular Genetics

Andrew, S.E. and Goldberg, Y.P. and Hayden, M.R.

Of molecular interactions, mice and mechanisms: New insights into Huntington's disease

Current Opinion in Neurology

Wellington, C.L. and Hayden, M.R.

Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients - The Ser(447)-Stop substitution in the lipoprotein lipase gene

Circulation

Groenemeijer, BE and Hallman, MD and Reymer, PWA and Gagne, E and Kuivenhoven, JA and Bruin, T and Jansen, H and Lie, KI and Bruschke, AVG and Boerwinkle, E and Hayden, MR and Kastelein, JJP

Different mutation rates of similar sized CAG tracts of affected Huntington disease chromosomes by single sperm analysis

American Journal of Human Genetics

Almqvist, E. and Chong, S. S. and Nichol, K. and Telenius, H. and La Tray, L. and Bourdelat-Parks, B. and Haddad, B. R. and Squitieri, F. and Anvret, M. and Van den Engh, G. and Hayden, M.

Common mutations in the lipoprotein lipase gene influence plasma lipids and prevalence of coronary heart disease

Atherosclerosis

Hayden, MR and Gagne, SE and Larson, MG and Wittekoek, ME and Pimstone, SN and Schaefer, EJ and Defesche, JC and Wilson, PWF and Kastelein, JJP and Ordovas, JM

Caspase cleavage of huntingtin, atrophin-1 and androgen receptor

American Journal of Human Genetics

Wellington, CL and Margolis, RL and Trifiro, MA and Ross, CA and Pinsky, L and Nicholson, DW and Hayden, MR

Pathological association and dissociation of functional systems in multiple sclerosis and Huntington's disease

Journal of Clinical and Experimental Neuropsychology

Clark, C.M. and Jacova, C. and Klonoff, H. and Kremer, B. and Hayden, M. and Paty, D.

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane- associated huntingtin in the brain

Nature Genetics

Kalchman, M.A. and Koide, H.B. and McCutcheon, K. and Graham, R.K. and Nichol, K. and Nishiyama, K. and Kazemi-Esfarjani, P. and Lynn, F.C. and Wellington, C. and Metzler, M. and Goldberg, Y.P. and Kanazawa, I. and Gietz, R.D. and Hayden, M.R.

Genetic variant showing a positive interaction with -blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients: The Ser447- stop substitution in the lipoprotein lipase gene

Circulation

Groenemeijer, B.E. and Hallman, M.D. and Reymer, P.W.A. and Gagn, E. and Kuivenhoven, J.A. and Bruin, T. and Jansen, H. and Lie, K.I. and Bruschke, A.V.G. and Boerwinkle, E. and Hayden, M.R. and Kastelein, J.J.P.

Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: Identification of a unique haplotype of the apolipoprotein B-100 allele

Atherosclerosis

Abdel-Wareth, L.O. and Pimstone, S.N. and Lagarde, J.-P. and Raisonnier, A. and Benlian, P. and Pritchard, H. and Hayden, M.R. and Frohlich, J.J.

Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans

Journal of Biological Chemistry

Nielsen, M.S. and Brejning, J. and Garca, R. and Zhang, H. and Hayden, M.R. and Vilar, S. and Gliemann, J.

Ethnic variation and in vivo effects of the -93t->g promoter variant in the lipoprotein lipase gene

Arteriosclerosis Thrombosis and Vascular Biology

Ehrenborg, E and Clee, SM and Pimstone, SN and Reymer, PWA and Benlian, P and Hoogendijk, CF and Davis, HJ and Bissada, N and Miao, L and Gagne, SE and Greenberg, LJ and Henry, R and Henderson, H and Ordovas, JM and Schaefer, EJ and Kastelein, JJP and Kotze, MJ and Hayden, MR

Effects of the Ser447Stop mutation in the lipoprotein lipase gene locus on plasma triglyceride rich lipoprotein remnants

Circulation

Ordovas, JM and Gagne, E and McNamara, JR and Shah, PK and Wilson, PWF and Cupples, AL and Hayden, MR and Schaefer, EJ

Dilemmas of anonymous predictive testing for Huntington disease: Privacy vs. optimal care

American Journal of Medical Genetics

Burgess, M.M. and Adam, S. and Bloch, M. and Hayden, M.R.

Assessment of French patients with LPL deficiency for French Canadian mutations

Journal of Medical Genetics

Foubert, L. and De Gennes, J.L. and Lagarde, J.P. and Ehrenborg, E. and Raisonnier, A. and Girardet, J.P. and Hayden, M.R. and Benlian, P.

A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in moroccans of Berber ancestry

Human Mutation

Foubert, L. and Bruin, T. and De Gennes, J.L. and Ehrenborg, E. and Furioli, J. and Kastelein, J. and Benlian, P. and Hayden, M.

Premature atherosclerosis in familial chylomicronemia [5]

New England Journal of Medicine

Pedro-Botet, J. and Rubies-Prat, J. and Benlian, P. and Hayden, M.R.

Phenotypic variation in familial hypercholesterolemia: A comparison of Chinese patients heterozygous for the same or similar mutations in the low density lipoprotein-receptor gene living in China or Canada

Atherosclerosis

Sun, XM and Pimstone, SN and deSouich, C and Frohlich, J and Hayden, MR and Soutar, AK

Molecular genetics as tools to redefine the clinics of lipoprotein disorders: The examples of lipoprotein lipase deficiency

Atherosclerosis

Benlian, P. and Hayden, M. and deGennes, J. L.

Interleukin-1-converting enzyme (ICE) and related cell death genes ICE(rel)-II and ICE(rel)-III map to the same PAC clone at band 11q22.2-22.3

Mammalian Genome

Nasir, J. and Theilmann, J.L. and Vaillancourt, J.P. and Munday, N.A. and Ali, A. and Scherer, S. and Beatty, B. and Nicholson, D.W. and Hayden, M.R.

Development of YAC transgenic mice expressing mutant human huntingtin containing different sized polyglutamine tracts.

American Journal of Human Genetics

Hodgson, G and Smith, D and Nichol, K and Bissada, N and McCutcheon, K and LePaine, F and Stevens, M and Okusky, JR and Phillips, T and Rubin, EM and Hayden, MR

Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase

Arteriosclerosis Thrombosis and Vascular Biology

Excoffon, KJDA and Liu, GQ and Miao, L and Wilson, JE and McManus, BM and Semenkovich, CF and Coleman, T and Benoit, P and Duverger, N and Branellec, D and Denefle, P and Hayden, MR and Lewis, MES

Analysis of cholesteryl ester transfer activity in adipose tissue

International Journal of Obesity

Shen, G.X. and Zhang, J.Y. and Blanchard, R. and Zhang, H.-F. and Hayden, M. and McPherson, R. and Angel, A.

Origin and migration of an Afrikaner founder mutation FH(Afrikaner-2) (V408M) causing familial hypercholesterolemia

Gene Geography

Defesche, J.c. and Van Diermen, D.E. and Hayden, M.R. and Kastelein, J.P.P.

MED-PED: An integrated genetic strategy for preventing early deaths

Genetic Approaches To Noncommunicable Diseases

Williams, RR and HamiltonCraig, I and Kostner, GM and Hegele, RA and Hayden, MR and Pimstone, SN and Faergeman, O and Schuster, H and SteinhagenThiessen, E and Beisiegel, U and Keller, C and Czeizel, AE and Leitersdorf, E and Kastelein, JC and Defesche, JJP and Ose, L and Leren, TP and Seftel, HC and Raal, FJ and Marais, AD and Eriksson, M and Keller, U and Miserez, AR and Jeck, T and Betterridge, DJ and Humphries, SE and Day, INM and Kwiterovich, PO and Lees, RS and Stein, E and Illingworth, R and Kane, J and Boulyjenkov, V and Berg, K and Christen, Y

Gene-based therapeutic strategies for human lipoprotein lipase (LPL) deficiency: Rationale and prospects for alteration of atherogenic risk

Transfusion Science

Lewis, M.E.S. and Liu, G. and Ginzinger, D.G. and Benoit, P. and Jones, S.D. and Ashbourne, K.J.D. and Wilson, J.E. and McManus, B.M. and Duverger, N. and Denefle, P.P. and Hayden, M.R.

A mutation in the lipoprotein lipase gene is the molecular basis of chylomicronemia in a colony of domestic cats

Journal of Clinical Investigation

Ginzinger, D.G. and Lewis, M.E.S. and Ma, Y. and Jones, B.R. and Liu, G. and Jones, S.D. and Hayden, M.R.

A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron triglyceride and retinyl palmitate response in normolipidemic carriers

Journal of Lipid Research

Pimstone, S.N. and Clee, S.M. and Gagn, S.E. and Miao, L. and Zhang, H. and Stein, E.A. and Hayden, M.R.

Unified Huntington's disease rating scale: Reliability and consistency

Movement Disorders

Kieburtz, K. and Penney, J. B. and Como, P. and Ranen, N. and Shoulson, I. and Feigin, A. and Abwender, D. and Greenamyre, J. T. and Higgins, D. and Marshall, F. J. and Goldstein, J. and Steinberg, K. and Shih, C. and Richard, I. and Hickey, C. and Zimmerman, C. and Orme, C. and Claude, K. and Oakes, D. and Sax, D. S. and Kim, A. and Hersch, S. and Jones, R. and Auchus, A. and Olsen, D. and BisseyBlack, C. and Rubin, A. and Schwartz, R. and Dubinsky, R. and Mallonee, W. and Gray, C. and Godfrey, N. and Suter, G. and Shannon, K. M. and Stebbins, G. T. and Jaglin, J. A. and Marder, K. and Taylor, S. and Louis, E. and Moskowitz, C. and Thorne, D. and Zubin, N. and Wexler, N. and Swenson, M. R. and Paulsen, J. and Swerdlow, N. and Albin, R. and Wernette, C. and Walker, F. and Hunt, V. and Roos, R. A. C. and Young, A. B. and Koroshetz, W. and Bird, E. and Meyers, R. and Cudkowicz, M. and Guttman, M. and StCyr, J. and Burkholder, J. and Lundin, A. and Ashizawa, T. and Jankovic, J. and Siemers, E. and Quaid, K. and Martin, W. and SanchezRamos, J. and Facca, A. and Rey, G. and Suchowersky, O. and Rohs, G. and Klinek, M. L. and Ross, C. and Bylsma, F. W. and Sherr, M. and Hayden, M. and Raymond, L. and Clark, C. and Kremer, B.

Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familiar combined hyperlipoproteinemia in French Canadian subjects

Journal of Lipid Research

Marcil, M. and Boucher, B. and Gagne, E. and Davignon, J. and Hayden, M. and Genest, J.

Effects of lipoprotein lipase gene mutations on plasma lipids: The Framingham Offspring Study.

Circulation

Gagne, SE and Pimstone, SN and Larson, MG and Schaefer, EJ and Wilson, PWF and Ordovas, JM and Hayden, MR

A long term (ca 5 years) prospective assessment of psychological consequences of predictive testing for Huntington disease (HD)

American journal of human genetics

Wiggins, S. and Green, T. and Adam, S. and Hayden, M.R.

Reduced cholesteryl ester transfer in plasma of patients with lipoprotein lipase deficiency

Journal of Lipid Research

Bagdade, J.D. and Ritter, M.C. and Lithell, H. and Bassett, D. and Mailly, F. and Talmud, P. and Hayden, M.R.

Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250 Asn; Ser251 Cys) resulting in lipoprotein lipase (LPL) deficiency

Netherlands Journal of Medicine

Bijvoet, S.M. and Wiebusch, H. and Ma, Y. and Reymer, P.W.A. and Bruin, T. and Bakker, H.D. and Funke, H. and Assmann, G. and Hayden, M.R. and Kastelein, J.J.P.

Common sequence variants of lipoprotein lipase: Standardized studies of in vitro expression and catalytic function

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

Zhang, H. and Henderson, H. and Gagne, S.E. and Clee, S.M. and Miao, L. and Liu, G. and Hayden, M.R.

Predictive testing for Huntington disease: Lessons for other adult onset disorders

Genetic Approaches To Noncommunicable Diseases

Hayden, MR and Berg, K and Boulyjenkov, V and Christen, Y

Lack of association of the apolipoprotein A-I-C-III-A-IV gene Xmnl and Sstl polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects

Journal of Lipid Research

Marcil, M. and Boucher, B. and Gagn, E. and Davignon, J. and Hayden, M. and Genest Jr., J.

Combined effect of familial hypercholesterolemia and lipoprotein lipase deficiency in determining low density lipoprotein size, buoyancy and lipid composition

Journal of Investigative Medicine

Zambon, A. and Hokanson, J.E. and Gagne, C. and Lupien, P.J. and Moorjani, S. and Hayden, M.R. and Brunzell, J.D.

Treatment of familial hypercholesterolemia in children and adolescents: Effect of lovastatin

Pediatrics

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The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis

Circulation

Jukema, J.W. and Van Boven, A.J. and Groenemeijer, B. and Zwinderman, A.H. and Reiber, J.H.C. and Bruschke, A.V.G. and Henneman, J.A. and Molhoek, G.P. and Bruin, T. and Jansen, H. and Gagn, E. and Hayden, M.R. and Kastelein, J.J.P.

The Asp(9) Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis

Circulation

Jukema, JW and vanBoven, AJ and Groenemeijer, B and Zwinderman, AH and Reiber, JHC and Bruschke, AVG and Henneman, JA and Molhoek, GP and Bruin, T and Jansen, H and Gagne, E and Hayden, MR and Kastelein, JJP

Patients' rights to laboratory data: Trinucleotide repeat length in huntington disease

American Journal of Medical Genetics

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Lipoprotein lipase increases HDL levels in mice expressing cholesterol ester transfer protein

Circulation

Clee, SM and Zhang, HF and Benlian, P and Miao, L and Bissada, N and Shen, GX and Angel, A and LeBoeuf, FC and Hayden, MR

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

Journal of Biological Chemistry

Kalchman, MA and Graham, RK and Xia, G and Koide, HB and Hodgson, JG and Graham, KC and Goldberg, YP and Gietz, RD and Pickart, CM and Hayden, MR

Heterozygous mutations in the lipoprotein lipase gene contribute to chylomicronemia in the adult

Journal of Investigative Medicine

Nevin, D.N. and Deeb, S.S. and Hayden, M.R. and Brunzell, J.D.

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript

Human Molecular Genetics

Goldberg, Y.P. and Kalchman, M.A. and Metzler, M. and Nasir, J. and Zeisler, J. and Graham, R. and Koide, H.B. and O'Kusky, J. and Sharp, A.H. and Ross, C.A. and Jirik, F. and Hayden, M.R.

Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats

American Journal of Human Genetics

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LPL gene mutation, causing only subtle changes in plasma lipids, promotes progression of coronary atherosclerosis which can be reversed by pravastatin

Circulation

Jukema, JW and vanBoven, AJ and Groenemeyer, B and Zwinderman, AH and Reiber, JHC and Bruschke, AVG and Henneman, JA and Molhoek, P and Bruin, T and Gagne, E and Hayden, MR and Kastelein, JJ

Diet-induced atherosclerosis in normal and LPL deficient heterozygote cats

Laboratory Investigation

Ginzinger, D. and Redenbach, D. and Wilson, J. E. and Lewis, S. and Betts, J. and McManus, B. M. and Hayden, M.

Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency

American Journal of Human Genetics

Benlian, P. and Foubert, L. and Gagn, E. and Bernard, L. and De Gennes, J.L. and Langlois, S. and Robinson, W. and Hayden, M.

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

Nature Genetics

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Adverse psychological events occurring in the first year after predictive testing for Huntington's disease

Journal of Medical Genetics

Lawson, K. and Wiggins, S. and Green, T. and Adam, S. and Bloch, M. and Hayden, M.R. and Klimek, M. and Suchowersky, O. and Grover, S. and Bamforth, S. and Shokeir, M.H.K. and Greenberg, C. and Kane, J. and Soltan, H. and Eisenberg, D. and Whelan, D. and MacGregor, D. and Summers, A. and Meschino, W. and Hunter, A. and MacLeod, P. and Dufrasne, S. and Rosenblatt, D. and Prevost, C. and Fuller, A. and Welch, P. and Ives, E.

A new mutation destroying disulphide bridging in the C-terminal domain of lipoprotein lipase

Biochemical and Biophysical Research Communications

Henderson, H.E. and Hassan, F. and Marais, D. and Hayden, M.R.

Update on genetics of Huntington's disease: availability of direct and accurate predictive test.

Italian journal of neurological sciences

Squitieri, F. and Campanella, G. and Hayden, M.R.

Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene

New England Journal of Medicine

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Origin and migration of an Afrikaner founder mutation FHAfrikaner-2 (V408M) causing familial hypercholesterolemia

Gene Geography

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Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme

Journal of Biological Chemistry

Kalchman, M.A. and Graham, R.K. and Xia, G. and Brook Koide, H. and Graeme Hodgson, J. and Graham, K.C. and Paul Goldberg, Y. and Dan Gietz, R. and Pickart, C.M. and Hayden, M.R.

Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency

Journal of Lipid Research

Bijvoet, S. and Gagn, S.E. and Moorjani, S. and Gagn, C. and Henderson, H.E. and Fruchart, J.-C. and Dallongeville, J. and Alaupovic, P. and Prins, M. and Kastelein, J.J.P. and Hayden, M.R.

A common alteration in the LPL gene resulting in altered lipoprotein levels

Nutrition, Genetics, and Heart Disease

Pimstone, S and Gagne, E and Zhang, H and Reymer, P and Kastelein, JJP and Ma, Y and Hayden, MR and Bray, GA and Ryan, DH

Huntington disease: New insights into the relationship between CAG expansion and disease

Human Molecular Genetics

Nasir, J. and Goldberg, Y.P. and Hayden, M.R.

Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype

Human Molecular Genetics

Hodgson, J.G. and Smith, D.J. and McCutcheon, K. and Koide, H.B. and Nishiyama, K. and Dinulos, M.B. and Stevens, M.E. and Bissada, N. and Nasir, J. and Kanazawa, I. and Disteche, C.M. and Rubin, E.M. and Hayden, M.R.

A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) contributes to the expression of familial combined hyperlipidemia

Human Molecular Genetics

Reymer, P.W.A. and Groenemeyer, B.E. and Gagn, E. and Miao, L. and Appelman, E.E.G. and Seidel, J.C. and Kromhout, D. and Bijvoet, S.M. and Van De Oever, K. and Bruin, T. and Hayden, M.R. and P.kastelein, J.J.

Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human Chromosome 4q21.2 by fluorescence in situ hybridization

Mammalian Genome

Leung, P.C.K. and Squire, J. and Peng, C. and Fan, N. and Hayden, M.R. and Olofsson, J.I.

Hereditary late-onset chorea without significant dementia: Genetic evidence for substantial phenotypic variation in Huntington's disease

Neurology

Britton, J.W. and Uitti, R.J. and Ahlskog, J.E. and Robinson, R.G. and Kremer, B. and Hayden, M.R.

TARGETED DISRUPTION OF THE HUNTINGTONS-DISEASE GENE RESULTS IN EMBRYONIC LETHALITY IN HOMOZYGOTES AND BEHAVIORAL AND NEUROPATHOLOGICAL DEFECTS IN HETEROZYGOTES

American Journal of Human Genetics

Nasir, J. and Floresco, S. and Okusky, J. and Diewert, V. and Richman, J. and Zeisler, J. and Borowski, A. and Metzler, M. and Graham, R. and Marth, J. and Phillips, A. and Hayden, M.

SOMATIC MOSAICISM IN SPERM IS ASSOCIATED WITH INTERGENERATIONAL (CAG)N CHANGES IN HUNTINGTON DISEASE (VOL 4, PG 189, 1995)

Human Molecular Genetics

TELENIUS, H and ALMQVIST, E and KREMER, B and SPENCE, N and SQUITIERI, F and NICHOL, K and GRANDELL, U and STARR, E and BENJAMIN, C and CASTALDO, I and CALABRESE, O and ANVRET, M and GOLDBERG, YP and HAYDEN, MR

POSTPRANDIAL RETINYL PALMITATE RESPONSE SUPPORTS EVIDENCE FOR A FUNCTIONAL EFFECT OF THE ASN291SER MUTATION IN THE LIPOPROTEIN-LIPASE GENE

Circulation

PIMSTONE, SN and GAGNE, E and CLEE, SM and STEIN, EA and HAYDEN, MR

Mutations in the Gene for Lipoprotein Lipase a Cause for Low HDL Cholesterol Levels in Individuals Heterozygous for Familial Hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Pimstone, S.N. and Gagn, S.E. and Gagn, C. and Lupien, P.J. and Gaudet, D. and Williams, R.R. and Kotze, M. and Reymer, P.W.A. and Defesche, J.C. and Kastelein, J.J.P. and Moorjani, S. and Hayden, M.R.

Long-term efficacy and tolerability of simvastatin in a large cohort of elderly hypercholesterolemic patients

Atherosclerosis

Lansberg, P.J. and Mitchel, Y.B. and Shapiro, D. and Kastelein, J.J.P. and Altman, R. and Jerums, G. and Bolzano, K. and Giannini, S. and Davignon, J. and DeWailly, P. and Darioli, R. and Mancini, M. and Scott, R. and Hayden, M.R.

LACK OF ASSOCIATION OF THE APO AI-CIII-AIV GENE XMNL AND SSTL POLYMORPHISMS AND OF LPL GENE-MUTATIONS IN FAMILIAL COMBINED HYPERLIPOPROTEINEMIA IN FRENCH-CANADIAN SUBJECTS

Circulation

Marcil, M. and Boucher, B. and Gagne, E. and Davignon, J. and Hayden, M. and Genest, J.

INCREASED INSTABILITY OF INTERMEDIATE ALLELES IN FAMILIES WITH SPORADIC HUNTINGTON DISEASE COMPARED TO INTERMEDIATE ALLELES IN THE GENERAL-POPULATION - IMPLICATIONS FOR GENETIC-COUNSELING

American Journal of Human Genetics

GOLDBERG, YP and ZIESLER, J and ALMQVIST, E and SILLENCE, D and RICHARDS, F and BUCHANAN, J and TELENIUS, H and HAYDEN, MR

Summary of the 1993 ASHG ancillary meeting 'recent research on chromosome 4p syndromes and genes'

American Journal of Medical Genetics

Estabrooks, L.L. and Breg, W.R. and Hayden, M.R. and Ledbetter, D.H. and Myers, R.M. and Wyandt, H.E. and Yang-Feng, T.L. and Hirschhorn, K.

Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in huntington disease

Human Molecular Genetics

Telenius, H. and Almqvist, E. and Kremer, B. and Spence, N. and Squitieri, F. and Nichol, K. and Grandell, U. and Starr, E. and Benjamin, C. and Castaldo, I. and Calabrese, O. and Anvret, M. and Goldberg, Y.P. and Hayden, M.R.

MECHANISMS UNDERLYING (CAG) EXPANDION IN HUNTINGTON DISEASE INCLUDE TISSUE-SPECIFIC AND CIS-ACTING FACTORS

Journal of Cellular Biochemistry

TELENIUS, H and ALMQVIST, E and KREMER, B and SPENCE, N and NICHOL, K and SQUITIERI, F and THEILMANN, J and ANVRET, M and GOLDBERG, YP and HAYDEN, MR

Genomic organization of the human a-adducin gene and its alternately spliced isoforms

Genomics

Lin, B. and Nasir, J. and McDonald, H. and Graham, R. and Rommens, J.M. and Goldberg, Y.P. and Hayden, M.R.

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

Cell

Nasir, J. and Floresco, S.B. and O'Kusky, J.R. and Diewert, V.M. and Richman, J.M. and Zeisler, J. and Borowski, A. and Marth, J.D. and Phillips, A.G. and Hayden, M.R.

PREDICTIVE TESTING FOR HUNTINGTONS-DISEASE (HD) - DIFFERENCES IN UPTAKE AND CHARACTERISTICS OF LINKED MARKER AND DIRECT TEST COHORTS

American Journal of Human Genetics

Adam, S. and Wiggins, S. and Lawson, K. and McKellin, B. and Hayden, M.

Patients with ApoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291Ser mutation in the human LPL gene

Arteriosclerosis, Thrombosis, and Vascular Biology

Zhang, H. and Reymer, P.W.A. and Liu, M.-S. and Forsythe, I.J. and Groenemeyer, B.E. and Frohlich, J. and Brunzell, J.D. and Kastelein, J.J.P. and Hayden, M.R. and Ma, Y.

LIPOPROTEIN ANALYSIS IN A COLONY OF LIPOPROTEIN-LIPASE DEFICIENT CATS

Circulation

GINZINGER, DG and DALLONGEVILLE, J and ROGERS, Q and HAYDEN, MR

Erratum: Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in Huntington disease(Human Molecular Genetics(1995)4(189-195))

Human Molecular Genetics

Telenius, H. and Almqvist, E. and Kremer, B. and Spence, N. and Squitieri, F. and Nichol, K. and Grandell, U. and Starr, E. and Benjamin, C. and Castaldo, I. and Calabrese, O. and Anvret, M. and Goldberg, Y.P. and Hayden, M.R.

Ancestral differences in the distribution of the d2642 glutamic acid polymorphism is associated with varying CAG repeat lengths on normal chromosomes: Insights into the genetic evolution of huntington disease

Human Molecular Genetics

Almqvist, E. and Spence, N. and Nichol, K. and Andrew, S.E. and Vesa, J. and Peltonen, L. and Anvret, M. and Goto, J. and Kanazawa, I. and Goldberg, Y.P. and Hayden, M.R.

A 2-YEAR PROSPECTIVE ASSESSMENT OF SOCIAL AND PSYCHOLOGICAL CONSEQUENCES OF PREDICTIVE TESTING FOR HUNTINGTONS-DISEASE (HD)

American Journal of Human Genetics

WIGGINS, S and COPLEY, T and ADAM, S and LAWSON, K and HAYDEN, MR

PATIENT RIGHTS TO LABORATORY DATA - TRINEUCLEOTIDE REPEAT LENGTH IN HUNTINGTON DISEASE

American Journal of Human Genetics

Adams, S. and Almqvist, E. and Burgess, M. and Hayden, M.

Origins and evolution of huntington disease chromosomes

Neurodegeneration

Andrew, S.E. and Hayden, M.R.

Erratum: Somatic mosaicism in sperm is associated with intergenerational (cag)n changes in huntington disease

Human Molecular Genetics

Telenius, H. and Almqvist, E. and Kremer, B. and Spence, N. and Squitieri, F. and Nichol, K. and Grandell, U. and Starr, E. and Benjamin, C. and Castaldo, I. and Calabrese, O. and Anvret, M. and Goldberg, Y.P. and Hayden, M.R.

Structural analysis of the 5' region of mouse and human huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms

Genomics

Lin, B. and Nasir, J. and Kalchman, M.A. and McDonald, H. and Zeisler, J. and Goldberg, Y.P. and Hayden, M.R.

RETROVIRAL-MEDIATED GENE-TRANSFER AND EXPRESSION OF HUMAN LIPOPROTEIN-LIPASE IN SOMATIC-CELLS

Human Gene Therapy

LEWIS, MES and FORSYTHE, IJ and MARTH, JD and BRUNZELL, JD and HAYDEN, MR and HUMPHRIES, RK

Retroviral-mediated gene transfer and expression of human lipoprotein lipase in somatic cells

Human Gene Therapy

Lewis, M.E.S. and Forsythe, I.J. and Marth, J.D. and Brunzell, J.D. and Hayden, M.R. and Humphries, R.K.

MUTATIONS IN THE GENE FOR LIPOPROTEIN-LIPASE - A CAUSE FOR LOW HDL CHOLESTEROL LEVELS IN INDIVIDUALS HETEROZYGOUS FOR FAMILIAL HYPERCHOLESTEROLEMIA

Arteriosclerosis Thrombosis and Vascular Biology

PIMSTONE, SN and GAGNE, SE and GAGNE, C and LUPIEN, PJ and GAUDET, D and WILLIAMS, RR and KOTZE, M and REYMER, PWA and DEFESCHE, JC and KASTELEIN, JJP and MOORJANI, S and HAYDEN, MR

Many roads lead to atheroma

Nature Medicine

Hayden, M.R. and Reidy, M.

FALSE NEGATIVES AND POSITIVES IN PREDICTIVE TESTING FOR HUNTINGTON DISEASE THE IMPORTANCE OF ACCURATE ASSESSMENT OF THE ADJACENT CCG REPEAT

American Journal of Human Genetics

ALMQVIST, E and GOLDBERG, YP and HAYDEN, MR

YAC TRANSGENIC MICE CONTAINING THE HUNTINGTON DISEASE GENE

American Journal of Human Genetics

HODGSON, G and SMITH, D and TELENIUS, H and NASIR, J and RUBIN, EM and HAYDEN, MR

STRUCTURAL FEATURES IN LIPOPROTEIN-LIPASE NECESSARY FOR THE MEDIATION OF LIPOPROTEIN UPTAKE INTO CELLS

Journal of Lipid Research

KRAPP, A and ZHANG, HF and GINZINGER, D and LIU, MS and LINDBERG, A and OLIVECRONA, G and HAYDEN, MR and BEISIEGEL, U

Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes

American Journal of Human Genetics

Kremer, B. and Almqvist, E. and Theilmann, J. and Spence, N. and Telenius, H. and Goldberg, Y.P. and Hayden, M.R.

Psychological effects of predictive testing for Huntington's disease.

Advances in neurology

Hayden, M.R. and Bloch, M. and Wiggins, S.

HEREDITARY LATE-ONSET CHOREA WITHOUT SIGNIFICANT DEMENTIA - GENETIC-EVIDENCE FOR SUBSTANTIAL PHENOTYPIC VARIATION IN HUNTINGTONS-DISEASE

Neurology

BRITTON, JW and UITTI, RJ and AHLSKOG, JE and ROBINSON, RG and KREMER, B and HAYDEN, MR

COMPLETE PATERNAL ISODISOMY OF CHROMOSOME-8 UNMASKED BY THE MOLECULAR CHARACTERIZATION OF LIPOPROTEIN-LIPASE DEFICIENCY

American Journal of Human Genetics

BENLIAN, P and FOUBERT, L and BERNARD, L and GAGNE, E and FORSYTHE, I and LAGARDE, IP and TELENIUS, H and LANGLOIS, S and DEGENNES, IL and HAYDEN, MR

Are we all of one mind? Clinicians' and patients' opinions regarding the development of a service protocol for predictive testing for Huntington disease

American Journal of Medical Genetics

Copley, T.T. and Wiggins, S. and Dufrasne, S. and Bloch, M. and Adam, S. and McKellin, W. and Hayden, M.R. and Ives, E. and Welch, J.P. and Fuller, A. and Miller, S. and Andermann, E. and Roy, M. and McLeod, P. and Hunter, A. and Meschino, W. and Summers, A. and Whelan, D. and Eisenberg, D.

TRANSACTIVATIONAL ANALYSIS OF THE GLUTAMINE-RICH REGIONS OF THE HUMAN ANDROGEN RECEPTOR AND THE HUNTINGTON DISEASE GENE

American Journal of Human Genetics

KAZEMIESFARJANI, P and GOLDBERG, YP and YAO, J and DETOURREIL, AS and TRIFIRO, M and HAYDEN, MR and PINSKY, L

Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells

Journal of Lipid Research

Krapp, A. and Zhang, H. and Ginzinger, D. and Liu, M.-S. and Lindberg, A. and Olivecrona, G. and Hayden, M.R. and Beisiegel, U.

PATIENTS WITH APOE3 DEFICIENCY (E2/2, E3/2, AND E4/2) WHO MANIFEST WITH HYPERLIPIDEMIA HAVE INCREASED FREQUENCY OF AN ASN 291-]SER MUTATION IN THE HUMAN LPL GENE

Arteriosclerosis Thrombosis and Vascular Biology

ZHANG, HF and REYMER, PWA and LIU, MS and FORSYTHE, IJ and GROENEMEYER, BE and FROHLICH, J and BRUNZELL, JD and KASTELEIN, JJP and HAYDEN, MR and MA, YH

Increased instability of intermediate alleles in families with sporadic huntington disease compared to similar sized intermediate alleles in the general population

Human Molecular Genetics

Goldberg, Y.P. and Mcmurray, C.T. and Zeisier, J. and Almqvist, E. and Sillence, D. and Richards, F. and Gacy, A.M. and Buchanan, J. and Telenius, H. and Hayden, M.

A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis

Nature Genetics

Reymer, P.W.A. and Gagn, E. and Groenemeyer, B.E. and Zhang, H. and Forsyth, I. and Jansen, H. and Seidell, J.C. and Kromhout, D. and Lie, K.E. and Kastelein, J. and Hayden, M.R.

A compound heterozygote for lipoprotein lipase deficiency, Val69Leu and Gly188Glu: Correlation between in vitro LPL activity and clinical expression

Journal of Lipid Research

Bruin, T. and Tuzgol, S. and Mulder, W.J. and Van den Ende, A.E. and Jansen, H. and Hayden, M.R. and Kastelein, J.J.P.

Homozygosity for a mutation in the lipoprotein lipase gene (Gly139Ser) causes chylomicronaemia in a boy of Spanish descent

Human Genetics

Bijvoet, S.M. and Bruin, T. and Thzgl, S. and Bakker, H.D. and Hayden, M.R. and Kastelein, J.J.P.

Guidelines for the molecular genetics predictive test in Huntington's disease

Journal of Medical Genetics

Went., L. and Broholm, J. and Cassiman, J.-J. and Craufurd, D. and Falek, A. and Farmer-Little, C. and Hayden, M. and Kapp, R. and Krahnen, K. and Martinez-Descals, A. and Mol, M. and Myrianthopoulos, N. and Petit, H. and Quaid, K. and De Somviele, C. and Taylor, E. and Tyler, A. and Walker, R. and Wexler, N.

Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase

Journal of Biological Chemistry

Liu, M.-S. and Jirik, F.R. and LeBoeuf, R.C. and Henderson, H. and Castellani, L.W. and Lusis, A.J. and Ma, Y. and Forsythe, I.J. and Zhang, H. and Kirk, E. and Brunzell, J.D. and Hayden, M.R.

Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase

Journal of Lipid Research

Ma, Y. and Henderson, H.E. and Liu, M.-S. and Zhang, H. and Forsythe, I.J. and Clarke-Lewis, I. and Hayden, M.R. and Brunzell, J.D.

HUNTINGTON DISEASE WITHOUT CAG EXPANSION - PHENOCOPIES OR ERRORS IN ASSIGNMENT

American Journal of Human Genetics

ANDREW, SE and GOLDBERG, YP and KREMER, B and SQUITIERI, F and THEILMANN, J and ZEISLER, J and TELENIUS, H and ADAM, S and ALMQUIST, E and ANVRET, M and LUCOTTE, G and STOESS, AJ and CAMPANELLA, G and HAYDEN, MR

HIGH-FREQUENCY OF MUTATIONS IN THE HUMAN LIPOPROTEIN-LIPASE GENE IN PREGNANCY-INDUCED CHYLOMICRONEMIA - POSSIBLE ASSOCIATION WITH APOLIPOPROTEIN E2 ISOFORM

Journal of Lipid Research

MA, YH and OOI, TC and LIU, MS and ZHANG, HF and MCPHERSON, R and EDWARDS, AL and FORSYTHE, IJ and FROHLICH, J and BRUNZELL, JD and HAYDEN, MR

High frequency of mutations in the human lipoprotein lipase gene in pregnancy-induced chylomicronemia: Possible association with apolipoprotein E2 isoform

Journal of Lipid Research

Ma, Y. and Ooi, T.C. and Liu, M.-S. and Zhang, H. and McPherson, R. and Edwards, A.L. and Forsythe, I.J. and Frohlich, J. and Brunzell, J.D. and Hayden, M.R.

Geographical distribution of haplotypes in Swedish families with Huntington's disease

Human Genetics

Almqvist, E. and Andrew, S. and Theilmann, J. and Goldberg, P. and Zeisler, J. and Drugge, U. and Grandell, U. and Tapper-Persson, M. and Winblad, B. and Hayden, M. and Anvret, M.

A TRANSCRIPTION MAP OF THE HUNTINGTON DISEASE LOCUS

Cytogenetics and Cell Genetics

GOLDBERG, YP and ROMMENS, JR and HUTCHINSON, GB and ANDREW, SE and GRAHAM, RK and LIN, BY and THEILMANN, J and NASIR, J and KALCHMAN, MA and SHAPPERT, K and CLARKE, L and HAYDEN, MR

A COMPOUND HETEROZYGOTE FOR LIPOPROTEIN-LIPASE DEFICIENCY, VAL(69)- LEU AND GLY(188)- GLU - CORRELATION BETWEEN IN-VITRO LPL ACTIVITY AND CLINICAL EXPRESSION

Journal of Lipid Research

Bruin, T. and Tuzgol, S. and Mulder, W. J. and Vandenende, A. E. and Jansen, H. and Hayden, M. R. and Kastelein, J. J. P.

U-type exchange in a paracentric inversion as a possible mechanism of origin of an inverted tandem duplication of chromosome 8

American Journal of Medical Genetics

Mitchell, J.J. and Vekemans, M. and Luscombe, S. and Hayden, M. and Weber, B. and Richter, A. and Sparkes, R. and Kojis, T. and Watters, G. and Der Kaloustian, V.M.

SOMATIC AND GONADAL MOSAICISM OF THE HUNTINGTON DISEASE GENE CAG REPEAT IN BRAIN AND SPERM (VOL 6, PG 409, 1994)

Nature Genetics

TELENIUS, H and KREMER, B and GOLDBERG, YP and THEILMANN, J and ANDREW, SE and ZEISLER, J and ADAM, S and GREENBERG, C and IVES, J and CLARKE, LA and HAYDEN, MR

Sequence of the murine huntington dusease gene: Evidence for conservation, and polymorphism in a triplet (CCG) repeat alternate splicing

Human Molecular Genetics

Lin, B. and Nasir, J. and Macdonald, H. and Hutchinson, G. and Graham, R.K. and Rommesns, J.M. and Hayden, M.R.

Regional cerebral glucose metabolism in huntington's disease: A statistical investigation

Human Brain Mapping

Clark, C.M. and Kremer, B. and Hayden, M.R.

Precise mapping of the brain a2-Adrenergic receptor gene within chromosome 4p16

Genomics

Riess, O. and Thies, U. and Siedlaczck, I. and Potisek, S. and Graham, R. and Theilmann, J. and Grimm, T. and Epplen, J.T. and Hayden, M.R.

Normal CAG repeat length in the huntingtons disease gene in senile chorea

Neurology

Shinotoh, H. and Calne, D.B. and Snow, B. and Hayward, M. and Kremer, B. and Theilmann, J. and Hayden, M.R.

Murine a-l-Iduronidase: cDNA isolation and expression

Genomics

Clarke, L.A. and Nasir, J. and Zhang, H. and McDonald, H. and Applegarth, D.A. and Hayden, M.R. and Toone, J.

GEOGRAPHICAL-DISTRIBUTION OF HAPLOTYPES IN SWEDISH FAMILIES WITH HUNTINGTONS-DISEASE

Human Genetics

Almqvist, E. and Andrew, S. and Theilmann, J. and Goldberg, P. and Zeisler, J. and Drugge, U. and Grandell, U. and Tapperpersson, M. and Winblad, B. and Hayden, M. and Anvret, M.

The murine homologues of the huntington disease gene (Hdh) and the a-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3

Genomics

Nasir, J. and Lin, B. and Bucan, M. and Koizumi, T. and Nadeau, J.H. and Hayden, M.R.

GENE ENVIRONMENT INTERACTION AND PLASMA TRIGLYCERIDE LEVELS - THE CRUCIAL ROLE OF LIPOPROTEIN-LIPASE

Clinical Genetics

HAYDEN, MR and LIU, MS and MA, YH

FAMILIAL LATE-ONSET CHOREA (WITHOUT OTHER FEATURES) MAY BE HUNTINGTONS-DISEASE

Neurology

BRITTON, JW and UITTI, RJ and AHLSKOG, JE and ROBINSON, RG and KREMER, B and HAYDEN, MR

DNA haplotype analysis of huntington disease reveals clues to the origins and mechanisms of CAG expansion and reasons for geographic variations of prevalence

Human Molecular Genetics

Squitieri, F. and Andrew, S.E. and Goldberg, Y.P. and Kremer, B. and Spence, N. and Zelsler, J. and Nichol, K. and Theilmann, J. and Greenberg, J. and Goto, J. and Kanazawa, I. and Vesa, J. and Peltonen, L. and Almqvist, E. and Anvret, M. and Telenius, H. and Lin, B. and Napolitano, G. and Morgan, K. and Hayden, M.R.

ALTERATION OF LIPID PROFILES IN PLASMA OF TRANSGENIC MICE EXPRESSING HUMAN LIPOPROTEIN-LIPASE

Journal of Biological Chemistry

LIU, MS and JIRIK, FR and LEBOEUF, RC and HENDERSON, H and CASTELLANI, LW and LUSIS, AJ and MA, YH and FORSYTHE, IJ and ZHANG, HF and KIRK, E and BRUNZELL, JD and HAYDEN, MR

A MUTATION (N291S) IN THE LPL GENE OCCURS WITH INCREASED FREQUENCY IN PATIENTS WITH PREMATURE ATHEROSCLEROSIS AND HYPERLIPIDEMIA

Circulation

REYMER, PWA and GAGNE, E and GROENEMEYER, BE and MA, YH and APPLEMAN, EEG and VANDEROEVER, K and BRUIN, T and SEIDEL, JC and KASTELEIN, JJP and HAYDEN, MR

Recurrent missense mutations at the first and second base of codon Arg243 in human lipoprotein lipase in patients of different ancestries

Human Mutation

Ma, Y. and Liu, M.?S. and Chitayat, D. and Bruin, T. and Beisiegel, U. and Benlian, P. and Foubert, L. and De Gennes, J.L. and Funke, H. and Forsythe, I. and Blaichman, S. and Papanikolaou, M. and Erkelens, D.W. and Kastelein, J. and Brunzell, J.D. and Hayden, M.R.

PROCEED WITH CARE - DIRECT PREDICTIVE TESTING FOR HUNTINGTON DISEASE

American Journal of Human Genetics

BENJAMIN, CM and ADAM, S and WIGGINS, S and THEILMANN, JL and COPLEY, TT and BLOCH, M and SQUITIERI, F and MCKELLIN, W and COX, S and BROWN, SA and KREMER, HPH and BURGESS, M and MESHINO, W and SUMMERS, A and MACGREGOR, D and BUCHANAN, J and GREENBERG, C and CARSON, N and IVES, E and FRECKER, M and WELCH, JP and FULLER, A and ROSENBLATT, D and MILLER, S and DUFRASNE, S and ROY, M and ANDERMANN, E and PREVOST, C and KHALIFA, M and GIRARD, K and TAYLOR, S and HUNTER, A and GOLDSMITH, C and WHELAN, D and EISENBERG, D and SOLTAN, H and KANE, J and SHOKEIR, MHK and GIBSON, A and CARDWELL, S and BAMFORTH, S and GROVER, S and SUCHOWERSKY, O and KLIMEK, M and GARBER, T and GARDNER, HA and MACLEOD, P and HAYDEN, MR

Erratum: Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm (Nature Genetics (1994) 6 (409-413))

Nature Genetics

Telenius, H. and Kremer, B. and Goldberg, Y.P. and Theilmann, J. and Andrew, S.E. and Zeisler, J. and Adam, S. and Greenberg, C. and Ives, E.J. and Clarke, L.A. and Hayden, M.R.

Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia

The American Journal of Cardiology

Davignon, J. and Roederer, G. and Montigny, M. and Hayden, M.R. and Tan, M.-H. and Connelly, P.W. and Hegele, R. and McPherson, R. and Lupien, P.J. and Gagn, C. and Little, J.A. and Colin, P.

Apolipoprotein CII-Padova (Tyr37stop) as a cause of chylomicronaemia in an Italian kindred from Siculiana

Journal of Medical Genetics

Tuzgl, S. and Bijvoet, S.M. and Bruin, T. and Kastelein, J.J.P. and Hayden, M.R.

NORMAL CAG REPEAT LENGTH IN THE HUNTINGTONS-DISEASE GENE IN SENILE CHOREA

Neurology

SHINOTOH, H and CALNE, DB and SNOW, B and HAYWARD, M and KREMER, B and THEILMANN, J and HAYDEN, MR

MUTAGENESIS IN 4 CANDIDATE HEPARIN-BINDING REGIONS (RESIDUE-279-282, RESIDUE-291-304, RESIDUE-390-393, AND RESIDUE-439-448) AND IDENTIFICATION OF RESIDUES AFFECTING HEPARIN-BINDING OF HUMAN LIPOPROTEIN-LIPASE

Journal of Lipid Research

MA, YH and HENDERSON, HE and LIU, MS and ZHANG, HF and FORSYTHE, IJ and CLARKELEWIS, I and HAYDEN, MR and BRUNZELL, JD

Issues in molecular genetic testing of individuals with suspected early-onset familial Alzheimer's disease

Alzheimer Disease and Associated Disorders

Karlinsky, H. and Sadovnick, A.D. and Burgess, M.M. and Langlois, S. and Hayden, M.R. and Berg, J.M.

IN-VITRO MUTAGENESIS STUDIES DEFINES THOSE RESIDUES OF LIPOPROTEIN-LIPASE CRITICAL FOR MEDIATION OF THE BINDING OF LIPOPROTEINS TO THE LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP)

Circulation

ZHANG, HF and KRAPP, A and MA, YH and GINZINGER, DG and BEISIEGEL, U and HAYDEN, MR

A CCG repeat polymorphism adjacent to the CAG repeat in the huntington disease gene: Implications for diagnostic accuracy and predictive testing

Human Molecular Genetics

Andrew, S.E. and Goldberg, Y.P. and Theilmann, J. and Zeisler, J. and Hayden, M.R.

THE MOLECULAR-GENETICS OF HUNTINGTONS-DISEASE

Current Opinion in Neurology

GOLDBERG, YP and TELENIUS, H and HAYDEN, MR

Huntington disease without CAG expansion: Phenocopies or errors in assignment?

American Journal of Human Genetics

Andrew, S.E. and Paul Goldberg, Y. and Kremer, B. and Squitieri, F. and Theilmann, J. and Zeisler, J. and Telenius, H. and Adam, S. and Almquist, E. and Anvret, M. and Lucotte, G. and Jon Stoessl, A. and Campanella, G. and Hayden, M.R.

GUIDELINES FOR THE MOLECULAR-GENETICS PREDICTIVE TEST IN HUNTINGTONS-DISEASE

Neurology

Broholm, J. and Cassiman, J. J. and Craufurd, D. and Falek, A. and Farmerlittle, C. and Hayden, M. and Kapp, R. and Krahnen, K. and Martinezdescals, A. and Mol, M. and Myrianthopoulos, N. and Petit, H. and Quaid, K. and Desomviele, C. and Taylor, E. and Tyler, A. and Walker, R. and Went, L. and Wexler, N.

APOLIPOPROTEIN CII-PADOVA (TYR(37)-]STOP) AS A CAUSE OF CHYLOMICRONEMIA IN AN ITALIAN KINDRED FROM SICULIANA

Journal of Medical Genetics

TUZGOL, S and BIJVOET, SM and BRUIN, T and KASTELEIN, JJP and HAYDEN, MR

The molecular genetics of Huntington's disease

Current Opinion in Neurology

Goldberg, Y.P. and Telenius, H. and Hayden, M.R.

Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm

Nature Genetics

Telenius, H. and Kremer, B. and Goldberg, Y.P. and Theilmann, J. and Andrew, S.E. and Zeisler, J. and Adam, S. and Greenberg, C. and Ives, E.J. and Clarke, L.A. and Hayden, M.R.

Sequence of the murine huntington disease gene: Evidence for conservation, alternate splicing and polymorphism in a triplet (ccg) repeat

Human Molecular Genetics

Lin, B. and Nasir, J. and Macdonald, H. and Hutchinson, G. and Graham, R.K. and Rommens, J.M. and Hayden, M.R.

Proceed with Care: Direct Predictive Testing for Huntington Disease

American Journal of Human Genetics

Benjamin, C.M. and Adam, S. and Wiggins, S. and Theilmann, J.L. and Copley, T.T. and Bloch, M. and Squitieri, F. and McKellin, W. and Cox, S. and Brown, S.A. and Kremer, H.P.H. and Burgess, M. and Meshino, W. and Summers, A. and Macgregor, D. and Buchanan, J. and Greenberg, C. and Carson, N. and Ives, E. and Frecker, M. and Welch, J.P. and Fuller, A. and Rosenblatt, D. and Miller, S. and Dufrasne, S. and Roy, M. and Andermann, E. and Prevost, C. and Khalifa, M. and Girard, K. and Taylor, S. and Hunter, A. and Goldsmith, C. and Whelan, D. and Eisenberg, D. and Soltan, H. and Kane, J. and Shokeir, M.H.K. and Gibson, A. and Cardwell, S. and Banforth, S. and Grover, S. and Suchowersky, O. and Klimek, M. and Garber, T. and Gardner, H.A. and MacLeod, P. and Hayden, M.R.

Gene environment interaction and plasma triglyceride levels: the crucial role of lipoprotein lipase

Clinical Genetics

Hayden, M.R. and Liu, M.?S. and Ma, Y.

Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Gagn, E. and Genest Jr., J. and Zhang, H. and Clarke, L.A. and Hayden, M.R.

A worldwide study of the huntington's disease mutation: The sensitivity and specificity of measuring CAG repeats

New England Journal of Medicine

Kremer, B. and Goldberg, P. and Andrew, S.E. and Theilmann, J. and Telenius, H. and Zeisler, J. and Squitieri, F. and Lin, B. and Bassett, A. and Almqvist, E. and Bird, T.D. and Hayden, M.R.

A PCR method for accurate assessment of trinucleotide repeat expansion in huntington disease

Human Molecular Genetics

Goldberg, Y.P. and Andrew, S.E. and Clarke, L.A. and Hayden, M.R.

THE RELATIONSHIP BETWEEN TRINUCLEOTIDE (CAG) REPEAT LENGTH AND CLINICAL-FEATURES OF HUNTINGTON DISEASE

American Journal of Human Genetics

ANDREW, SE and GOLDBERG, YP and KREMER, B and TELENIUS, H and THEILMANN, J and ADAM, S and STARR, E and SQUITIERI, F and LIN, B and KALCHMAN, MA and GRAHAM, RK and HAYDEN, MR

ON PLANTING ALFALFA AND GROWING ORCHIDS - THE CLONING OF THE GENE CAUSING HUNTINGTON DISEASE

Clinical Genetics

HAYDEN, MR

Genetic and phenotypic heterogeneity in familial lecithin: Cholesterol acyltransferase (LCAT) deficiency: Six newly identified defective alleles further contribute to the structural heterogeneity in this disease

Journal of Clinical Investigation

Funke, H. and Von Eckardstein, A. and Pritchard, P.H. and Hornby, A.E. and Wiebusch, H. and Motti, C. and Hayden, M.R. and Dachet, C. and Jacotot, B. and Gerdes, U. and Faergeman, O. and Albers, J.J. and Colleoni, N. and Catapano, A. and Frohlich, J. and Assmann, G.

Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172Cys mutation in the lipoprotein lipase gene

Journal of Clinical Investigation

Ma, Y. and Liu, M.-S. and Ginzinger, D. and Frohlich, J. and Brunzell, J.D. and Hayden, M.R.

EXPRESSION OF HUMAN LIPOPROTEIN-LIPASE IN TRANSGENIC MICE

Journal of Cellular Biochemistry

HAYDEN, MR and LIU, MS and JIRIK, F and MA, YH and LEBOUEF, R and BRUNZELL, JD

An Alu element retroposition in two families with huntington disease defines a new active alu subfamily

Nucleic Acids Research

Hutchinson, G.B. and Andrew, S.E. and Mcdonald, H. and Goldberg, Y.P. and Graham, R. and Rommens, J.M. and Hayden, M.R.

ACIDIC AND BASIC FIBROBLAST GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE STRIATUM AND MIDBRAIN IN HUNTINGDONS DISEASE (VOL 608, PG 78, 1993)

Brain Research

TOOYAMA, I and KREMER, HPH and HAYDEN, MR and KIMURA, H and MCGEER, EG and MCGEER, PL

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

Nature Genetics

Andrew, S.E. and Goldberg, Y.P. and Kremer, B. and Telenius, H. and Theilmann, J. and Adam, S. and Starr, E. and Squitieri, F. and Lin, B. and Kalchman, M.A. and Graham, R.K. and Hayden, M.R.

South African founder mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia in the Dutch population

Human Genetics

Defesche, J.C. and van Diermen, D.E. and Lansberg, P.J. and Lamping, R.J. and Reymer, P.W.A. and Hayden, M.R. and Kastelein, J.J.P.

Recurrent pancreatitis and chylomicronemia in an extended Dutch kindred is caused by a Gly154Ser substitution in lipoprotein lipase

Journal of Lipid Research

Bruin, T. and Tuzgol, S. and Van Diermen, D.E. and Hoogerbrugge-Van der Linden, N. and Brunzell, J.D. and Hayden, M.R. and Kastelein, J.J.P.

Phenotypic variation of mutations in the human lipoprotein-lipase gene

Biochemical Society Transactions

Hayden, M.R. and Kastelein, J.J. and Funke, H. and Brunzell, J.D. and Ma, Y.

MAPPING OF THE HUMAN NMDA RECEPTOR SUBUNIT (NMDAR1) AND THE PROPOSED NMDA RECEPTOR GLUTAMATE-BINDING SUBUNIT (NMDARA1) TO CHROMOSOME-9Q34.3 AND CHROMOSOME-8, RESPECTIVELY

Genomics

COLLINS, C and DUFF, C and DUNCAN, AMV and PLANELLSCASES, R and SUN, W and NORREMOLLE, A and MICHAELIS, E and MONTAL, M and WORTON, R and HAYDEN, MR

FAMILIAL PREDISPOSITION TO RECURRENT MUTATIONS CAUSING HUNTINGTONS-DISEASE - GENETIC RISK TO SIBS OF SPORADIC CASES

Journal of Medical Genetics

GOLDBERG, YP and ANDREW, SE and THEILMANN, J and KREMER, B and SQUITIERI, F and TELENIUS, H and BROWN, JD and HAYDEN, MR

EFFECT OF PARENTAL TRANSMISSION ON TRINUCLEOTIDE EXPANSION AND AGE AT ONSET OF SYMPTOMS IN JUVENILE HUNTINGTON DISEASE

American Journal of Human Genetics

TELENIUS, H and KREMER, B and ADAM, S and THEILMAN, J and ANDREW, SE and GOLDBERG, YP and SQUITIERI, F and STARR, E and ALMQUIST, E and ANVRET, M and GREENBERG, J and LUCOTTE, G and HAYDEN, MR

Diagnosis of Huntington disease: A model for the stages of psychological response based on experience of a predictive testing program

American Journal of Medical Genetics

Bloch, M. and Adam, S. and Fuller, A. and Kremer, B. and Welch, J.P. and Wiggins, S. and Whyte, P. and Huggins, M. and Theilmann, J. and Hayden, M.R.

ATTITUDES TOWARD DIRECT PREDICTIVE TESTING FOR THE HUNTINGTON DISEASE GENE - RELEVANCE FOR OTHER ADULT-ONSET DISORDERS

Jama-Journal of the American Medical Association

BABUL, R and ADAM, S and KREMER, B and DUFRASNE, S and WIGGINS, S and HUGGINS, M and THEILMANN, J and BLOCH, M and HAYDEN, MR

Presymptomatic testing for Huntington's disease: A world wide survey

Journal of Medical Genetics

Harper, P.S. and Ball, D.M. and Hayden, M.R.

Erratum: A transcription map of the region containing the Huntington disease gene (Human molecular genetics (1993) 2 (901-907))

Human Molecular Genetics

Rommens, J.M. and Lin, B. and Hutchinson, G.B. and Andrew, S.E. and Goldberg, Y.P. and Glaves, M.L. and Graham, R. and Lai, V. and McArthur, J. and Nasir, J. and Theilmann, J. and McDonald, H. and Kalchman, M. and Clarke, L.A. and Schappert, K. and Hayden, M.R.

Attitudes Toward Direct Predictive Testing for the Huntington Disease Gene: Relevance for Other Adult-Onset Disorders

JAMA: The Journal of the American Medical Association

Babul, R. and Adam, S. and Kremer, B. and Wiggins, S. and Huggins, M. and Theilmann, J. and Bloch, M. and Hayden, M.R. and Dufrasne, S.

A TRANSCRIPTION MAP OF THE REGION CONTAINING THE HUNTINGTON DISEASE GENE (VOL 2, PG 901, 1993)

Human Molecular Genetics

ROMMENS, JM and LIN, B and HUTCHINSON, GB and ANDREW, SE and GOLDBERG, YP and GLAVES, ML and GRAHAM, R and LAI, V and MCARTHUR, J and NASIR, J and THEILMANN, J and MCDONALD, H and KALCHMAN, M and CLARKE, LA and SCHAPPERT, K and HAYDEN, MR

SUPPORT FOR FOUNDER EFFECT FOR 2 LIPOPROTEIN-LIPASE (LPL) GENE-MUTATIONS IN FRENCH-CANADIANS BY ANALYSIS OF GT MICROSATELLITES FLANKING THE LPL GENE

Human Genetics

Wood, S. and Schertzer, M. and Hayden, M. and Ma, Y. H.

MOLECULAR-GENETICS OF LIPOPROTEIN-LIPASE DEFICIENCY

Drugs Affecting Lipid Metabolism

HAYDEN, MR and MA, YH and Catapano, AL and Gotto, AM and Smith, LC and Paoletti, R

MOLECULAR CHARACTERIZATION OF LIPOPROTEIN-LIPASE DEFICIENCY IN THE CAT - AN ANIMAL-MODEL FOR HUMAN LIPOPROTEIN-LIPASE DEFICIENCY

Circulation

GINZINGER, DG and MA, YH and LIU, MS and HARVEYCLARKE, C and BRUNZELL, JD and HAYDEN, MR

Molecular analysis of juvenile huntington disease: The major influence on (CAG)n repeat length is the sex of the affected parent

Human Molecular Genetics

Telenius, H. and Kremer, H.P.H. and Thellmann, J. and Andrew, S.E. and Almqvist, E. and Anvret, M. and Greenberg, C. and Greenberg, J. and Lucotte, G. and Squltierl, F. and Starr, A. and Goldberg, Y.P. and Hayden, M.R.

HUNTINGTON DISEASE - IDENTIFICATION OF A PREMUTATION

American Journal of Human Genetics

GOLDBERG, YP and KREMER, B and ANDREW, SE and THELLMANN, J and GRAHAM, RK and SQUITIERI, F and TELENIUS, H and ADAM, S and SAJOO, A and STARR, E and HELBERG, A and WOLFF, G and HAYDEN, MR

George Huntington: The man behind the eponym

Journal of Medical Genetics

Durbach, N. and Hayden, M.R.

COMPARISON OF THE SHORT-TERM EFFICACY AND TOLERABILITY OF LOVASTATIN AND SIMVASTATIN IN THE MANAGEMENT OF PRIMARY HYPERCHOLESTEROLEMIA

Canadian Journal of Cardiology

FROHLICH, J and BRUN, LD and BLANK, D and CAMPEAU, L and CROCKFORD, P and CURNEW, G and DAFOE, W and DAVIGNON, J and DUFOUR, R and EMERY, G and FERGUSSON, J and FILIPCHUK, N and GAGNE, C and HAYDEN, MR and LANGLOIS, S and LEITER, L and LERMAN, S and LUPIEN, PJ and MA, P and MCPHERSON, R and MCQUEEN, M and MISHKEL, M and MONTIGNY, M and NAKHLE, G and OOI, TT and ROEDERER, G and ROLEAU, JL and ROY, M and SECCOMBE, D and SNIDERMAN, AD and DUSOUICH, P and STEINER, G and VLAHOS, WD and XHIGNESSE, M and YOKOYAMA, S

TYPE-III HYPERLIPOPROTEINEMIA IN APOE2/2 HOMOZYGOTES - POSSIBLE ROLE OF MUTATIONS IN THE LIPOPROTEIN-LIPASE GENE

Circulation

MA, YH and ZHANG, HF and LIU, MS and FROHLICH, J and BRUNZELL, JD and HAYDEN, MR

STRUCTURE-FUNCTION-RELATIONSHIPS OF LIPOPROTEIN-LIPASE - MUTATION ANALYSIS AND MUTAGENESIS OF THE LOOP REGION

Journal of Lipid Research

HENDERSON, HE and MA, Y and LIU, MS and CLARKLEWIS, I and MAEDER, DL and KASTELEIN, JJP and BRUNZELL, JD and HAYDEN, MR

DNA analysis of distinct populations suggests multiple origins for the mutation causing Huntington disease

Clinical Genetics

Andrew, S. and Theilmann, J. and Almqvist, E. and Norremolle, A. and Lucotte, G. and Anvret, M. and Sorensen, S.A. and Turpin, J.C. and Hayden, M.R.

(ca)n-dinucleotide repeat at the PDEB locus in 4p16.3

Human Molecular Genetics

Weber, B. and Riess, O. and Daneshvar, H. and Graham, R. and Hayden, M.R.

The psychological consequences of predictive testing for huntingtons disease

Obstetrical and Gynecological Survey

Wiggins, S. and Whyte, P. and Huggins, M. and Adam, S. and Theilmann, J. and Bloch, M. and Sheps, S.B. and Schechter, M.T. and Hayden, M.R.

The Consequences of Testing for Huntington's Disease

New England Journal of Medicine

Bird, T.D. and Bennett, R.L. and Lipe, H.P. and Wiggins, S. and Hayden, M.R.

Reinveting the wheel

American Journal of Medical Genetics

Kessler, S. and Hayden, M.R. and Adam, S. and Bloch, M. and Chapman, M.A.

Prevention of raised low-density lipoprotein cholesterol in a patient with familial hypercholesterolaemia and lipoprotein lipase deficiency

The Lancet

Zambon, A. and Brunzell, J.D. and Torres, A. and Gagne, C. and Moorjani, S. and Lupien, P.J. and Hayden, M.R. and Bijvoet, S.

PRESYMPTOMATIC TESTING FOR HUNTINGTONS-DISEASE - A WORLD WIDE SURVEY

Journal of Medical Genetics

HAYDEN, MR

MOLECULAR ANALYSIS OF LATE-ONSET HUNTINGTONS-DISEASE

Journal of Medical Genetics

KREMER, B and SQUITIERI, F and TELENIUS, H and ANDREW, SE and THEILMANN, J and SPENCE, N and GOLDBERG, YP and HAYDEN, MR

GENEALOGY AND REGIONAL DISTRIBUTION OF LIPOPROTEIN-LIPASE DEFICIENCY IN FRENCH-CANADIANS OF QUEBEC

Human Biology

DIONNE, C and GAGNE, C and JULIEN, P and MURTHY, MRV and ROEDERER, G and DAVIGNON, J and LAMBERT, M and CHITAYAT, D and MA, R and HENDERSON, H and LUPIEN, PJ and HAYDEN, MR and DEBRAEKELEER, M

Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease

Brain Research

Tooyama, I. and Kremer, H.P.H. and Hayden, M.R. and Kimura, H. and McGeer, E.G. and McGeer, P.L.

A 4 basepair deletion in exon 4 of the human lipoprotein lipase gene results in type I hyperlipoproteinemia

Human Molecular Genetics

Ma, Y. and Liu, M.-S. and Zhang, H. and J.forsythe, I. and D.brunzell, J. and R.hayden, M.

Support for founder effect for two lipoprotein lipase (LPL) gene mutations in French Canadians by analysis of GT microsatellites flanking the LPL gene

Human Genetics

Wood, S. and Schertzer, M. and Hayden, M. and Ma, Y.

Structure-function relationships of lipoprotein lipase: Mutation analysis and mutagenesis of the loop region

Journal of Lipid Research

Henderson, H.E. and Ma, Y. and Liu, M.-S. and Clark-Lewis, I. and Maeder, D.L. and Kastelein, J.J.P. and Brunzell, J.D. and Hayden, M.R.

Monoamines and their metabolites in Huntington's disease brain: Evidence for decreased catechol-O-methyltransferase activity

Biological Psychiatry

McGeer, E.G. and Kremer, B. and Hayden, M.R.

Molecular analysis of new mutations for Huntington's disease: Intermediate alleles and sex of origin effects

Nature Genetics

Goldberg, Y.P. and Kremer, B. and Andrew, S.E. and Theilmann, J. and Graham, R.K. and Squitieri, F. and Telenius, H. and Adam, S. and Sajoo, A. and Starr, E. and Heiberg, A. and Wolff, G. and Hayden, M.R.

Mapping of the Human NMDA Receptor Subunit (NMDAR1) and the Proposed NMDA Receptor Glutamate-Binding Subunit (NMDARA1) to Chromosomes 9q34.3 and Chromosome 8, Respectively

Genomics

Collins, C. and Duff, C. and Duncan, A.M.V. and Planells-Cases, R. and Sun, W. and Norremolle, A. and Michaelis, E. and Montal, M. and Worton, R. and Hayden, M.R.

LINKAGE AND MUTATIONAL ANALYSES OF 30 FAMILIES AFFECTED WITH LEBER CONGENITAL AMAUROSIS

Investigative Ophthalmology & Visual Science

Musarella, M. A. and Reiss, O. and Hayden, M. and Lambert, S. and Pembrey, M. and Fishman, G. and Leal, S. and Ott, J.

Identification of an Alu retrotransposition event in close proximity to a strong candidate gene for Huntington's disease

Nature

Goldberg, Y.P. and Rommens, J.M. and Andrew, S.E. and Hutchinson, G.B. and Lin, B. and Theilmann, J. and Graham, R. and Glaves, M.L. and Starr, E. and McDonald, H. and Nasir, J. and Schappert, K. and Kalchman, M.A. and Clarke, L.A. and Hayden, M.R.

Familial Defective Apolipoprotein B-100 Is Clinically Indistinguishable From Familial Hypercholesterolemia

Archives of Internal Medicine

Defesche, J.C. and Pricker, K.L. and Hayden, M.R. and Van Der Ende, B.E. and Kastelein, J.J.P.

EXPRESSION OF HUMAN LIPOPROTEIN-LIPASE IN TRANSGENIC MICE RESULTS IN REDUCED LEVELS OF PLASMA TRIGLYCERIDE AND SIGNIFICANT ALTERATIONS IN LIPID PROFILES

American Journal of Human Genetics

Liu, M. S. and Jirik, F. R. and Ma, Y. H. and Brunzell, J. D. and Leboeuf, R. and Hayden, M. R.

Differential 3' polyadenylation of the huntington disease gene results in two mRNA species with variable tissue expression

Human Molecular Genetics

Lin, B. and Rommens, J.M. and Graham, R.K. and Kalchman, M. and Macdonald, H. and Nasir, J. and Delaney, A. and Goldberg, Y.P. and Hayden, M.R.

Comparison of the short term efficacy and tolerability of lovastatin and simvastatin in the management of primary hypercholesterolemia,COMPARAISON DE L'EFFICACITE ET DE LA TOLERABILITE A COURT TERME DE LA LOVASTATINE ET DE LA SIMVASTATINE DANS LE TRAITEMENT DE L'HYPERCHOLESTEROLEMIE. PRIMAIRE

Canadian Journal of Cardiology

Frohlich, J. and Brun, L.D. and Blank, D. and Campeau, L. and Crockford, P. and Curnew, G. and Dafoe, W. and Davignon, J. and Dufour, R. and Emery, G. and Fergusson, J. and Filipchuk, N. and Gagne, C. and Hayden, M.R. and Langlois, S. and Leiter, L. and Lerman, S. and Lupien, P. and Ma, P.

ATTITUDES AND EXPECTED DEMAND FROM PERSONS AT RISK FOR HUNTINGTON DISEASE (HD) TOWARDS A NEW DIRECT MUTATION PREDICTIVE TEST

American Journal of Human Genetics

WIGGINS, S and BABUL, R and DUFRASNE, S and HAYDEN, MR

ARE WE ALL OF ONE MIND - SIGNIFICANT DIFFERENCES IN OPINION BETWEEN CLINICIAN AND PARTICIPANTS REGARDING THE DEVELOPMENT OF A SERVICE PROTOCOL FOR PREDICTIVE TESTING FOR HUNTINGTON DISEASE (HD)

American Journal of Human Genetics

COPLEY, TT and WIGGINS, S and DUFRASNE, S and HAYDEN, MR

ALU ELEMENT RETROPOSITION EVENTS IN THE HUNTINGTON DISEASE REGION AND IN THE CHOLINESTERASE GENE DEFINE A NEW ACTIVE ALU SUBFAMILY

American Journal of Human Genetics

HUTCHINSON, GB and ANDREW, SE and MCDONALD, H and GOLDBERG, YP and GRAHAM, R and ROMMENS, JM and HAYDEN, MR

A transcription map of the region containing the huntington disease gene

Human Molecular Genetics

Rommens, J.M. and Lin, B. and Hutchinson, G.B. and Andrew, S.E. and Goldberg, Y.P. and Glaves, M.L. and Graham, R. and Lal, V. and Mcarthur, J. and Nasir, J. and Theilmann, J. and Mcdonald, H. and Kalchman, M. and Clarke, L.A. and Schappert, K. and Hayden, M.R.

REINVENTING THE WHEEL - REPLY

American Journal of Medical Genetics

HAYDEN, MR and ADAM, S and BLOCH, M

RECURRENT PANCREATITIS AND CHYLOMICRONEMIA IN AN EXTENDED DUTCH KINDRED IS CAUSED BY A GLY154-] SER SUBSTITUTION IN LIPOPROTEIN-LIPASE

Journal of Lipid Research

BRUIN, T and TUZGOL, S and VANDIERMEN, DE and HOOGERBRUGGEVANDERLINDEN, N and BRUNZELL, JD and HAYDEN, MR and KASTELEIN, JJP

On planting alfalfa and growing orchids: The cloning of the gene causing Huntington disease

Clinical Genetics

Hayden, M.R.

Molecular analysis of late onset Huntington's disease

Journal of Medical Genetics

Kremer, B. and Squitieri, F. and Telenius, H. and Andrew, S.E. and Theilmann, J. and Spence, N. and Goldberg, Y.P. and Hayden, M.R.

GENETIC AND PHENOTYPIC HETEROGENEITY IN FAMILIAL LECITHIN - CHOLESTEROL ACYLTRANSFERASE (LCAT) DEFICIENCY - 6 NEWLY IDENTIFIED DEFECTIVE ALLELES FURTHER CONTRIBUTE TO THE STRUCTURAL HETEROGENEITY IN THIS DISEASE

Journal of Clinical Investigation

FUNKE, H and VONECKARDSTEIN, A and PRITCHARD, PH and HORNBY, AE and WIEBUSCH, H and MOTTI, C and HAYDEN, MR and DACHET, C and JACOTOT, B and GERDES, U and FAERGEMAN, O and ALBERS, JJ and COLLEONI, N and CATAPANO, A and FROHLICH, J and ASSMANN, G and KLEINGUNNEWIGK, M and RECKWERTH, A

Five year study of prenatal testing for Huntington's disease: Demand, attitudes, and psychological assessment

Journal of Medical Genetics

Adam, S. and Wiggins, S. and Whyte, P. and Bloch, M. and Shokeir, M.H.K. and Soltan, H. and Meschino, W. and Summers, A. and Suchowersky, O. and Welch, J.P. and Huggins, M. and Theilmann, J. and Hayden, M.R.

Familial predisposition to recurrent mutations causing Huntington's disease: Genetic risk to sibs of sporadic cases

Journal of Medical Genetics

Goldberg, Y.P. and Andrew, S.E. and Theilmann, J. and Kremer, B. and Squitieri, F. and Telenius, H. and Brown, J.D. and Hayden, M.R.

Erratum: Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntingdon's disease (Brain Res., 608 (1993) 78-86)

Brain Research

Tooyama, I. and Kremer, H.P.H. and Hayden, M.R. and Kimura, H. and McGeer, E.G. and McGeer, P.L.

Development of a program for identification of patients with familial hypercholesterolemia in British Columbia: A model for prevention of coronary disease

The American Journal of Cardiology

Hayden, M.R. and Josephson, R.

CONSEQUENCES OF TESTING FOR HUNTINGTONS-DISEASE - REPLY

New England Journal of Medicine

WIGGINS, S and HAYDEN, MR

CONCORDANCE BETWEEN QUANTIFIED NEUROLOGICAL EXAMINATION AND POSITRON EMISSION TOMOGRAPHY IN THE EARLIEST STAGES OF HUNTINGTONS-DISEASE

Neurology

KREMER, HPH and SNOW, B and CLARK, C and RUTH, T and HAYDEN, MR and MARTIN, WRW

Isolation and characterization of new highly polymorphic DNA markers from the huntington disease region

American Journal of Human Genetics

Weber, B. and Hedrick, A. and Andrew, S. and Riess, O. and Collins, C. and Kowbel, D. and Hayden, M.R.

MISMATCH PCR - A RAPID METHOD TO SCREEN FOR THE PRO(207)-]LEU MUTATION IN THE LIPOPROTEIN-LIPASE (LPL) GENE

Human Molecular Genetics

BIJVOET, SM and HAYDEN, MR

GENETIC EPIDEMIOLOGY OF LIPOPROTEIN-LIPASE DEFICIENCY IN SAGUENAY-LAC-ST-JEAN (QUEBEC, CANADA)

Annales De Genetique

DIONNE, C and GAGNE, C and JULIEN, P and MURTHY, MRV and LAMBERT, M and ROEDERER, G and DAVIGNON, J and HAYDEN, MR and LUPIEN, PJ and DEBRAEKELEER, M

Cortical glucose metabolism in huntington's disease

Neurology

Martin, W.R.W. and Clark, C. and Ammann, W. and Stoessl, A.J. and Shtybel, W. and Hayden, M.R.

2 NATURALLY-OCCURRING MUTATIONS AT THE 1ST AND 2ND BASES OF CODON ASPARTIC ACID-156 IN THE PROPOSED CATALYTIC TRIAD OF HUMAN LIPOPROTEIN-LIPASE - INVIVO EVIDENCE THAT ASPARTIC ACID-156 IS ESSENTIAL FOR CATALYSIS

Journal of Biological Chemistry

MA, YH and BRUIN, T and TUZGOL, S and WILSON, BI and ROEDERER, G and LIU, MS and DAVIGNON, J and KASTELEIN, JJP and BRUNZELL, JD and HAYDEN, MR

The prediction of exons through an analysis of spliceable open reading frames

Nucleic Acids Research

Hutchinson, G.B. and Hayden, M.R.

Predictive testing for Huntington disease in Canada: The experience of those receiving an increased risk

American Journal of Medical Genetics

Bloch, M. and Adam, S. and Wiggins, S. and Huggins, M. and Hayden, M.R.

DETECTION OF THE PRO664-LEU MUTATION IN THE LOW-DENSITY-LIPOPROTEIN RECEPTOR AND ITS RELATION TO LIPOPROTEIN(A) LEVELS IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA OF DUTCH ANCESTRY FROM THE NETHERLANDS AND CANADA

Clinical Genetics

DEFESCHE, JC and VANDEREE, MA and KASTELEIN, JJP and VANDIERMEN, DE and JANSSENS, NWE and VANDOORMAAL, JJ and HAYDEN, MR

A missense mutation (Asp250Asn) in exon 6 of the human lipoprotein lipase gene causes chylomicronemia in patients of different ancestries

Genomics

Ma, Y. and Wilson, B.I. and Bijvoet, S. and Henderson, H.E. and Cramb, E. and Roederer, G. and Ven Murthy, M.R. and Julien, P. and Bakker, H.D. and Kastelein, J.J.P. and Brunzell, J.D. and Hayden, M.R.

Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase: In vivo evidence that aspartic acid 156 is essential for catalysis

Journal of Biological Chemistry

Ma, Y. and Bruin, T. and Tuzgol, S. and Wilson, B.I. and Roederer, G. and Liu, M.-S. and Davignon, J. and Kastelein, J.J.P. and Brunzell, J.D. and Hayden, M.R.

PREVALENCE, GEOGRAPHICAL-DISTRIBUTION AND GENEALOGICAL INVESTIGATIONS OF MUTATION-188 OF LIPOPROTEIN-LIPASE GENE IN THE FRENCH-CANADIAN POPULATION OF QUEBEC

Clinical Genetics

BERGERON, J and NORMAND, T and BHARUCHA, A and VENMURTHY, MR and JULIEN, P and GAGNE, C and DIONNE, C and DEBRAEKELEER, M and BRUN, D and HAYDEN, MR and LUPIEN, PJ

Predictive testing for Huntington disease.

Journal of medical ethics

Huggins, M. and Hayden, M.R.

Predictive testing for Huntington disease in Canada: Adverse effects and unexpected results in those receiving a decreased risk

American Journal of Medical Genetics

Huggins, M. and Bloch, M. and Wiggins, S. and Adam, S. and Suchowersky, O. and Trew, M. and Klimek, M. and Greenberg, C.R. and Eleff, M. and Thompson, L.P. and Knight, J. and MacLeod, P. and Girard, K. and Theilmann, J. and Hedrick, A. and Hayden, M.R.

Mismatch PCR: A rapid method to screen for the Pro207 leu mutation in the lipoprotein lipase (LPL) gene

Human Molecular Genetics

M.bijvoet, S. and R.hayden, M.

GENE-ENVIRONMENT INTERACTION IN THE CONVERSION OF A MILD TO SEVERE HYPERTRIGLYCERIDEMIA IN A PATIENT HOMOZYGOUS FOR A SER172- CYS MUTATION IN THE LIPOPROTEIN-LIPASE GENE

Circulation

Ma, Y. H. and Liu, M. S. and Brunzell, J. and Hayden, M.

Exclusion of DNA changes in the "subunit of the c"GMP phosphodiesterase gene as the cause for Huntingtons disease

Nature Genetics

Riess, O. and Noerremoelle, A. and Collins, C. and Mah, D. and Weber, B. and Hayden, M.R.

THE SENSITIVITY OF POSITRON EMISSION TOMOGRAPHY IN SYMPTOMATIC HUNTINGTONS-DISEASE

Annals of Neurology

MARTIN, WRW and KREMER, HPH and SHTYBEL, W and HAYDEN, MR

The search for mutations in the gene for the beta subunit of the cGMP phosphodiesterase (PDEB) in patients with autosomal recessive retinitis pigmentosa

American Journal of Human Genetics

Riess, O. and Noerremoelle, A. and Weber, B. and Musarella, M.A. and Hayden, M.R.

THE LIPOPROTEIN-LIPASE GLY188-]GLU MUTATION IN SOUTH AFRICANS OF INDIAN DESCENT - EVIDENCE SUGGESTING COMMON ORIGINS AND AN INCREASED FREQUENCY

Journal of Medical Genetics

HENDERSON, HE and HASSAN, F and BERGER, GMB and HAYDEN, MR

Mapping of the epitope on lipoprotein lipase recognized by a monoclonal antibody (5D2) which inhibits lipase activity

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism

Liu, M.-S. and Ma, Y. and Hayden, M.R. and Brunzell, J.D.

GEOGRAPHIC-DISTRIBUTION AND GENEALOGY OF MUTATION 207 OF THE LIPOPROTEIN-LIPASE GENE IN THE FRENCH-CANADIAN POPULATION OF QUEBEC

Human Genetics

NORMAND, T and BERGERON, J and FERNANDEZMARGALLO, T and BHARUCHA, A and VENMURTHY, MR and JULIEN, P and GAGNE, C and DIONNE, C and DEBRAEKELEER, M and MA, R and HAYDEN, MR and LUPIEN, PJ

GENOMIC IMPRINTING IN THE INHERITANCE OF FAMILIAL HYPERTROPHIC CARDIOMYOPATHY

Circulation

ELSTEIN, E and CLARKE, LA and RAKOWSKI, H and PERRYMAN, MB and ROBERTS, R and WIGLE, ED and HAYDEN, MR and SOLE, MJ

Genetic epidemiology of lipoprotein lipase deficiency in Saguenay-Lac-St-Jean (Quebec, Canada)

Annales de Genetique

Dionne, C. and Gagne, C. and Julien, P. and Murthy, M.R.V. and Lambert, M. and Roederer, G. and Davignon, J. and Hayden, M.R. and Lupien, P.J. and De Braekeleer, M.

THE SEARCH FOR MUTATIONS IN THE GENE FOR THE BETA-SUBUNIT OF THE CGMP PHOSPHODIESTERASE (PDEB) IN PATIENTS WITH AUTOSOMAL RECESSIVE RETINITIS-PIGMENTOSA

American Journal of Human Genetics

RIESS, O and NOERREMOELLE, A and WEBER, B and MUSARELLA, MA and HAYDEN, MR

The lipoprotein lipase Gly188Glu mutation in South Africans of Indian descent: Evidence suggesting common origins and an increased frequency

Journal of Medical Genetics

Henderson, H.E. and Hassan, F. and Berger, G.M.B. and Hayden, M.R.

The human -subunit of rod photoreceptor cGMP phosphodiesterase: Complete retinal cDNA sequence and evidence for expression in brain

Genomics

Collins, C. and Hutchinson, G. and Kowbel, D. and Riess, O. and Weber, B. and Hayden, M.R.

PLASMA-LIPOPROTEINS AND LIPOPROTEIN-LIPASE IN FRENCH-CANADIANS HETEROZYGOUS FOR MISSENSE MUTATION IN THE LIPOPROTEIN-LIPASE GENE

Circulation

JULIEN, P and GAGNE, C and VENMURTHY, MR and MOORJANI, S and BRUNZELL, JD and HAYDEN, MR and LUPIEN, PJ

MOLECULAR-GENETICS OF HUMAN LIPOPROTEIN-LIPASE DEFICIENCY

Molecular and Cellular Biochemistry

HAYDEN, MR and MA, YH

The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates

Human Molecular Genetics

Collins, C. and Schappert, K. and Hayden, M.R.

Geographic distribution and genealogy of mutation 207 of the lipoprotein lipase gene in the French Canadian population of Qubec

Human Genetics

Normand, T. and Bergeron, J. and Fernandez-Margallo, T. and Bharucha, A. and Ven Murthy, M.R. and Julien, P. and Gagn, C. and Dionne, C. and De Braekeleer, M. and Ma, R. and Hayden, M.R. and Lupien, P.J.

Detection of the Pro664-Leu mutation in the low-density lipoprotein receptor and its relation to lipoprotein(a) levels in patients with familial hypercholesterolemia of Dutch ancestry from The Netherlands and Canada

Clinical Genetics

Defesche, J.C. and van de Ree, M.A. and Kastelein, J.J.P. and van Diermen, D.E. and Janssens, N.W.E. and van Doormaal, J.J. and Hayden, M.R.

CORTICAL GLUCOSE-METABOLISM IN HUNTINGTONS-DISEASE

Neurology

MARTIN, WRW and CLARK, C and AMMANN, W and STOESSL, AJ and SHTYBEL, W and HAYDEN, MR

Cloning and mapping of the a-adducin gene close to D4S95 and assessment of its relationship to huntington disease

Human Molecular Genetics

Goldberg, Y.P. and Lin, B.-Y. and Andrew, S.E. and Nasir, J. and Graham, R. and Glaves, M.L. and Hutchinson, G. and Theilmann, J. and Ginzinger, D.G. and Schappert, K. and Clarke, L. and Rommens, J.M. and Hayden, M.R.

A missense mutation Pro157Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity

European Journal of Biochemistry

BRUIN, T. and KASTELEIN, J.J.P. and VAN DIERMEN, D.E. and MA, Y. and HENDERSON, H.E. and STUYT, P.M.J. and STALENHOEF, A.F.H. and STURK, A. and BRUNZELL, J.D. and HAYDEN, M.R.

The Psychological Consequences of Predictive Testing for Huntingtons Disease

New England Journal of Medicine

Wiggins, S. and Whyte, P. and Huggins, M. and Adam, S. and Theilmann, J. and Bloch, M. and Sheps, S.B. and Schechter, M.T. and Hayden, M.R.

Prevalence, geographical distribution and genealogical investigations of mutation 188 of lipoprotein lipase gene in the French Canadian population of Qubec

Clinical Genetics

Bergeron, J. and Normand, T. and Bharucha, A. and van Murtby, M.R. and Julien, P. and Gagn, C. and Dionne, C. and de Braekeleer, M. and Brun, D. and Hayden, M.R. and Luplen, P.J.

POSITRON EMISSION TOMOGRAPHY SCANNING IN INDIVIDUALS AT RISK FOR HUNTINGTONS-DISEASE

Annals of Neurology

KREMER, HPH and SHTYBEL, W and SNOW, B and CLARK, C and THEILMANN, J and HAYDEN, MR and MARTIN, WRW

New Insights Into the Clinical Features, Pathogenesis and Molecular Genetics of Huntington Disease

Brain Pathology

Kremer, B. and Weber, B. and Hayden, M.R.

Linkage studies and mutation analysis of the PDEB gene in 23 families with leber congenital amaurosis

Human Mutation

Riess, O. and Weber, B. and Noeremolle, A. and Shaikh, R.A. and Hayden, M.R. and Musarella, M.A.

Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntingtons disease

Nature Genetics

Weber, B. and Riess, O. and Wolff, G. and Andrew, S. and Collins, C. and Graham, R. and Theilmann, J. and Hayden, M.R.

(CA)n-dinucleotide repeat polymorphism at the locus for the alpha2c adrenergic receptor (ADRA2C) on 4p16

Human Molecular Genetics

Riess, O. and Weber, B. and Hayden, M.R.

Nonrandom association between huntington disease and two loci separated by about 3 Mb on 4p16.3

Genomics

Andrew, S. and Theilmann, J. and Hedrick, A. and Mah, D. and Weber, B. and Hayden, M.R.

MUTAGENESIS IN THE PROPOSED HERPARIN-BINDING SITE OF HUMAN LIPOPROTEIN-LIPASE

Circulation

Ma, Y. H. and Liu, M. S. and Henderson, H. and Brunzell, J. and Hayden, M.

Molecular genetics of human lipoprotein lipase deficiency

Molecular and Cellular Biochemistry

Hayden, M.R. and Ma, Y.

CHARACTERIZATION OF 2 GENES IN A CANDIDATE REGION FOR THE HUNTINGTON DISEASE GENE

American Journal of Human Genetics

COLLINS, C and WEBER, B and KOWBEL, D and RIESS, O and HAYDEN, MR

THE FDG/PET METHODOLOGY FOR EARLY DETECTION OF DISEASE ONSET - A STATISTICAL-MODEL

Journal of Cerebral Blood Flow and Metabolism

CLARK, CM and AMMANN, W and MARTIN, WRW and TY, P and HAYDEN, MR

PREDICTIVE MEDICINE FOR LATE ONSET DISORDERS - THE EXPERIENCE OF HUNTINGTON DISEASE

American Journal of Human Genetics

HAYDEN, MR

NO HARM, POTENTIAL BENEFIT - THE ONE YEAR FOLLOW-UP OF PARTICIPANTS IN THE CANADIAN COLLABORATIVE STUDY OF PREDICTIVE TESTING (CCSPT) FOR HUNTINGTONS-DISEASE (HD)

American Journal of Human Genetics

Wiggins, S. and Whyte, P. and Hayden, M.

Linkage disequilibrium and modification of risk for huntington disease

American Journal of Human Genetics

Adam, S. and Theilmann, J. and Buetow, K. and Hedrick, A. and Collins, C. and Weber, B. and Huggins, M. and Hayden, M.

IDENTIFICATION OF THE MOLECULAR DEFECTS UNDERLYING CHYLOMICRONEMIA IN THE MAJORITY OF 75 SEPARATE PROBANDS WITH LPL DEFICIENCY

Clinical Research

HENDERSON, H and MA, Y and KASTELEIN, J and ROEDERER, G and JULIEN, P and BRUNZELL, J and HAYDEN, MR

AMINO-ACID SUBSTITUTION (ILE194-]THR) IN EXON-5 OF THE LIPOPROTEIN-LIPASE GENE CAUSES LIPOPROTEIN-LIPASE DEFICIENCY IN 3 UNRELATED PROBANDS - SUPPORT FOR A MULTICENTRIC ORIGIN

Journal of Clinical Investigation

HENDERSON, HE and MA, Y and HASSAN, MF and MONSALVE, MV and MARAIS, AD and WINKLER, F and GUBERNATOR, K and PETERSON, J and BRUNZELL, JD and HAYDEN, MR

A polymorphic DNA marker at the D10S106 locus

Nucleic Acids Research

Weber, B. and Riess, O. and Hayden, M.R.

PRENATAL TESTING FOR ADULT-ONSET DISORDERS - LOW ACCEPTANCE RATE IN FAMILIES WITH HUNTINGTON DISEASE (HD)

American Journal of Human Genetics

Adam, S. and Bloch, M. and Whyte, P. and Hayden, M.

Predictive testing for Huntington disease: Are we ready for widespread community implementation?

American Journal of Medical Genetics

Hayden, M.R.

Intrachromosomal location of the telomeric repeat (TTAGGG)n

Mammalian Genome

Weber, B. and Allen, L. and Magenis, R.E. and Goodfellow, P.J. and Smith, L. and Hayden, M.R.

IDENTIFICATION OF THE MOLECULAR DEFECTS UNDERLYING CHYLOMICRONEMIA AND THEIR CLINICAL AND HISTORICAL SIGNIFICANCE IN THE MAJORITY OF 71 SEPARATE PROBANDS WITH LPL DEFICIENCY

American Journal of Human Genetics

Ma, Y. and Henderson, H. and Kastelein, J. and Roederer, G. and Julien, P. and Chitayat, D. and Debraekeleer, M. and Brunzell, J. and Hayden, M.

Genetic linkage between Huntington disease and the D4S10 locus in South African families: further evidence against non-allelic heterogeneity

Human Genetics

Greenberg, L.J. and Martell, R.W. and Theilman, J. and Hayden, M.R. and Joubert, J.

Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Hill, J.S. and Hayden, M.R. and Frohlich, J. and Pritchard, P.H.

THE RELATIONSHIP BETWEEN CLINICAL, MOLECULAR GENETIC AND POSITRON EMISSION TOMOGRAPHY FINDINGS IN PERSONS AT RISK FOR HUNTINGTONS-DISEASE (HD)

American Journal of Human Genetics

Shtybel, W. and Martin, W. and Clark, C. and Ammann, W. and Hedrick, A. and Hayden, M.

MOLECULAR AND BIOCHEMICAL-EVIDENCE FOR AN INTERSTITIAL DELETION ASSOCIATED WITH AN INVERTED TANDEM DUPLICATION OF THE SHORT ARM OF CHROMOSOME-8

American Journal of Human Genetics

Mitchell, J. and Menard, E. and Delneste, D. and Scarpelli, H. and Luscombe, S. and Sparkes, R. and Hayden, M. and Weber, B. and Vekemans, M. and Kaloustian, V. D.

Identification of multiple CpG islands and associated conserved sequences in a candidate region for the Huntington disease gene

Genomics

Weber, B. and Collins, C. and Kowbel, D. and Riess, O. and Hayden, M.R.

GENETIC-LINKAGE BETWEEN HUNTINGTON DISEASE AND THE D4S10 LOCUS IN SOUTH-AFRICAN FAMILIES - FURTHER EVIDENCE AGAINST NON-ALLELIC HETEROGENEITY

Human Genetics

GREENBERG, LJ and MARTELL, RW and THEILMAN, J and HAYDEN, MR and JOUBERT, J

GENETIC AND ENVIRONMENTAL-FACTORS AFFECTING THE INCIDENCE OF CORONARY-ARTERY DISEASE IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

Arteriosclerosis and Thrombosis

HILL, JS and HAYDEN, MR and FROHLICH, J and PRITCHARD, PH

CHOREA IN A PATIENT WITH WOLF-HIRSCHHORN SYNDROME IMPLICATION FOR HUNTINGTON DISEASE

American Journal of Human Genetics

MACGREGOR, D and HEDRICK, A and HAYDEN, MR and VEKEMANS, M and CHITAYAT, D

A POINT MUTATION IN EXON-5 OF THE LIPOPROTEIN-LIPASE GENE ACCOUNTS FOR THE MAJORITY OF ALLELES SEEN IN THE FRENCH-CANADIAN POPULATION

Clinical Research

MA, Y and HENDERSON, HE and CLARKE, LA and MONSALVE, MV and JULIEN, P and LUPIEN, P and HAYDEN, MR

HYPERCHYLOMICRONEMIA IN A LARGE FAMILY OF DUTCH DESCENT IS POSSIBLY CAUSED BY BOTH A MISSENSE MUTATION IN THE LPL GENE AND THE APO CII GENE

Thrombosis and Haemostasis

BRUIN, T and BIJVOET, S and TUZGOL, S and VANDIERMEN, DE and BRUNZELL, JD and HAYDEN, MR and KASTELEIN, JJP

FUNCTIONAL-EVALUATION OF MUTANT LIPOPROTEIN-LIPASE CONTAINING MISSENSE MUTATIONS ENCODED BY EXON-5

Clinical Research

Peterson, J. and Santamarinafojo, S. and Hayden, M. and Deeb, S. and Brunzell, J.

DEVELOPMENT OF LABORATORY GUIDELINES FOR PREDICTIVE TESTING FOR HUNTINGTON DISEASE (HD)

American Journal of Human Genetics

THEILMANN, J and HEDRICK, A and MAH, D and HAYDEN, MR

A mutation in the human lipoprotein lipase gene as the most common cause of familial chylomicronemia in french canadians

New England Journal of Medicine

ma, Y. and Henderson, H.E. and Monsalve, M.V. and Clarke, L.A. and Hayden, M.R. and Ven Murthy, M.R. and Normand, T. and Julien, P. and Gagn, C. and Lupien, P.J. and Lambert, M. and Roederer, G. and Davignon, J. and Brunzell, J.

The FDG/PET methodology for early detection of disease onset: A statistical model

Journal of Cerebral Blood Flow and Metabolism

Clark, C.M. and Ammann, W. and Martin, W.R.W. and Ty, P. and Hayden, M.R.

IDENTIFICATION OF NEW POLYMORPHIC DNA MARKERS FROM A CANDIDATE REGION FOR THE HD GENE

Cytogenetics and Cell Genetics

WEBER, B and HEDRICK, A and RIESS, O and COLLINS, C and ANDREWS, S and HAYDEN, MR

Genetic variants affecting human lipoprotein and hepatic lipases

Current Opinion in Lipidology

Hayden, M.R. and Yuanhong, Ma. and Brunzell, J. and Henderson, H.E.

Amino acid substitution (Ile194 Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands: Support for a multicentric origin

Journal of Clinical Investigation

Henderson, H.B. and Ma, Y. and Hassan, M.F. and Monsalve, M.V. and Marais, A.D. and Winkler, F. and Gubernator, K. and Peterson, J. and Brunzell, J.D. and Hayden, M.R.

Genomic organization and complete sequence of the human gene encoding the -subunit of the cGMP phosphodiesterase and its localisation to 4p16.3

Nucleic Acids Research

Weber, B. and Riess, O. and Hutchinson, G. and Collins, C. and Lin, B. and Kowbel, D. and Andrew, S. and Schappert, K. and Hayden, M.R.

A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini

Cytogenetics and Cell Genetics

Weber, B. and Allen, L. and Magenis, R.E. and Hayden, M.R.

MUTATIONS IN THE LPL-GENE CAUSING HYPERCHYLOMICRONEMIA IN THE NETHERLANDS

Thrombosis and Haemostasis

TUZGOL, S and BIJVOET, S and BRUNZELL, JD and HAYDEN, MR and KASTELEIN, JJP

MOLECULAR CHARACTERIZATION OF AN UNDETECTED SUBMICROSCOPIC DELETION CAUSING WOLF-HIRSCHHORN SYNDROME

American Journal of Human Genetics

Maclaren, L. and Bamforth, J. and Lin, C. and Hoar, D. and Molnar, L. and Hedrick, A. and Hayden, M.

IDENTIFICATION OF MULTIPLE CPG ISLANDS AND ASSOCIATED TRANSCRIPTS IN AN EXTENDED COSMID WALK OF 460-KB IN A CANDIDATE REGION FOR THE HUNTINGTON DISEASE (HD) GENE

American Journal of Human Genetics

WEBER, B and COLLINS, C and RIESS, O and KOWBEL, D and HAYDEN, MR

Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)n

Nucleic Acids Research

Weber, B. and Collins, C. and Robbins, C. and Magenis, R.E. and Delaney, A.D. and Gray, J.W. and Hayden, M.R.

The gene causing familial hypoalphalipoproteinemia is not caused by a defect in the apo AI-CIII-AIV gene cluster in a Spanish family

Human Genetics

Kastelein, J.J.P. and Haines, J.L. and Hayden, M.R.

PREDICTIVE TESTING FOR HUNTINGTON DISEASE IN CHILDHOOD - CHALLENGES AND IMPLICATIONS - OPINION

American Journal of Human Genetics

BLOCH, M and HAYDEN, MR

Regional Cerebral Glucose Metabolism in Turner Syndrome

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Clark, C. and Klonoff, H. and Hayden, M.

Partial gene duplication involving exon-Alu interchange results in lipoprotein lipase deficiency

American Journal of Human Genetics

Devlin, R.H. and Deeb, S. and Brunzell, J. and Hayden, M.R.

Frameshift mutation in exon 3 of the lipoprotein lipase gene causes a premature stop codon and lipoprotein lipase deficiency

Molecular Biology and Medicine

Henderson, H.E. and Devlin, R. and Peterson, J. and Brunzell, J.D. and Hayden, M.R.

CHARACTERIZATION OF A LIPOPROTEIN-LIPASE CLASS-III TYPE DEFECT IN HYPERTRIGLYCERIDEMIC CATS

Clinical and Investigative Medicine-Medecine Clinique Et Experimentale

Peritz, L. N. and Brunzell, J. D. and Harveyclarke, C. and Pritchard, P. H. and Jones, B. R. and Hayden, M. R.

Genetics, hyperlipidemia and atherosclerosis: An update

Current Opinion in Lipidology

Hayden, M.R.

ETHICAL AND LEGAL DILEMMAS ARISING DURING PREDICTIVE TESTING FOR ADULT-ONSET DISEASE - THE EXPERIENCE OF HUNTINGTON DISEASE

American Journal of Human Genetics

Huggins, M. and Bloch, M. and Kanani, S. and Quarrell, O. W. J. and Theilman, J. and Hedrick, A. and Dickens, B. and Lynch, A. and Hayden, M.

PARTIAL GENE DUPLICATION INVOLVING EXON-ALU INTERCHANGE RESULTS IN LIPOPROTEIN-LIPASE DEFICIENCY

American Journal of Human Genetics

DEVLIN, RH and DEEB, S and BRUNZELL, J and HAYDEN, MR

FRAMESHIFT MUTATION IN EXON-3 OF THE LIPOPROTEIN-LIPASE GENE CAUSES A PREMATURE STOP CODON AND LIPOPROTEIN-LIPASE DEFICIENCY

Molecular Biology & Medicine

HENDERSON, HE and DEVLIN, R and PETERSON, J and BRUNZELL, JD and HAYDEN, MR

DNA testing for Huntington disease results in a modification of risk and not diagnosis of disease

European Journal of Pediatrics

Bloch, M. and Hayden, M.R. and Schmig-Spingler, M.

Opinion: Predictive testing for Hungtington disease in childhood: Challenges and implications

American Journal of Human Genetics

Bloch, M. and Hayden, M.R.

IDENTIFICATION OF SEVERAL MOLECULAR DEFECTS RESPONSIBLE FOR FAMILIAL LECITHIN - CHOLESTEROL ACYLTRANSFERASE (LCAT) DEFICIENCY

Arteriosclerosis

Funke, H. and Voneckardstein, A. and Pritchard, P. H. and Hayden, M. R. and Albers, J. J. and Jacotot, B. and Gerdes, U. and Assmann, G.

HUMAN LIPOPROTEIN-LIPASE - FROM GENE TO PROTEIN

Drugs Affecting Lipid Metabolism X

HAYDEN, MR and BRUNZELL, JD and GOTTO, AM and SMITH, LC

GENETIC AND ENVIRONMENTAL-FACTORS AFFECTING THE INCIDENCE OF CORONARY-ARTERY DISEASE IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (FH)

Arteriosclerosis

HILL, JS and HAYDEN, MR and FROHLICH, J and PRITCHARD, H

Ethical and legal dilemmas arising during predictive testing for adult-onset disease: The experience of Huntington disease

American Journal of Human Genetics

Huggins, M. and Bloch, M. and Kanani, S. and Quarrell, Q.W.J. and Theilman, J. and Hedrick, A. and Dickens, B. and Lynch, A. and Hayden, M.

THE GENE CAUSING FAMILIAL HYPOALPHALIPOPROTEINEMIA IS NOT CAUSED BY A DEFECT IN THE APO-AI-CIII-AIV GENE-CLUSTER IN A SPANISH FAMILY

Human Genetics

KASTELEIN, JJP and HAINES, JL and HAYDEN, MR

REGIONAL CEREBRAL GLUCOSE-METABOLISM IN TURNER SYNDROME

Canadian Journal of Neurological Sciences

Clark, C. and Klonoff, H. and Hayden, M.

A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries

Journal of Clinical Investigation

Monsalve, M.V. and Henderson, H. and Roederer, G. and Julien, P. and Deeb, S. and Kastelein, J.J.P. and Peritz, L. and Devlin, R. and Bruin, T. and Murthy, M.R.V. and Cagne, C. and Davignon, J. and Lupien, P.J. and Brunzell, J.D. and Hayden, M.R.

Characterization of a lipoprotein lipase class III type defect in hypertriglyceridemic cats

Clinical and Investigative Medicine

Peritz, L.N. and Brunzell, J.D. and Harvey-Clarke, C. and Pritchard, P.H. and Jones, B.R. and Hayden, M.R.

Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90

American Journal of Human Genetics

Robbins, C. and Theilmann, J. and Youngman, S. and Haines, J. and Altherr, M.J. and Harper, P.S. and Payne, C. and Junker, A. and Wasmuth, J. and Hayden, M.R.

CHARACTERIZATION OF 6 PARTIAL DELETIONS IN THE LOW-DENSITY-LIPOPROTEIN (LDL) RECEPTOR GENE CAUSING FAMILIAL HYPERCHOLESTEROLEMIA (FH) AND PREMATURE ATHEROSCLEROSIS

Thrombosis and Haemostasis

KASTELEIN, JJP and LANGLOIS, S and HAYDEN, MR

Insurance and the Presymptomatic Diagnosis of Delayed-Onset Disease

JAMA: The Journal of the American Medical Association

Quarrell, O.W.J. and Bloch, M. and Hayden, M.R.

Huntington disease: No evidence for locus heterogeneity

Genomics

Conneally, P.M. and Haines, J.L. and Tanzi, R.E. and Wexler, N.S. and Penchaszadeh, G.K. and Harper, P.S. and Folstein, S.E. and Cassiman, J.J. and Myers, R.H. and Young, A.B. and Hayden, M.R. and Falek, A. and Tolosa, E.S. and Crespi, S. and Di Maio, L. and Holmgren, G. and Anvret, M. and Kanazawa, I. and Gusella, J.F.

FAMILIAL LIPOPROTEIN-LIPASE DEFICIENCY

Atherosclerosis Viii

BRUNZELL, JD and AUWERX, JH and BABIRAK, SP and DEEB, S and FUJIMOTO, WY and HAYDEN, MR and CREPALDI, G and GOTTO, AM and MANZATO, E and BAGGIO, G

Epiphyseal dysplasia, microcephaly, nystagmus, and retinitis pigmentosa

American Journal of Medical Genetics

Lowry, R.B. and Wood, B.J. and Cox, T.A. and Hayden, M.R.

A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency

Proceedings of the National Academy of Sciences of the United States of America

Langlois, S. and Deeb, S. and Brunzell, J.D. and Kastelein, J.J. and Hayden, M.R.

A DELETION MAP OF THE WAGR REGION ON CHROMOSOME-II

American Journal of Human Genetics

Gessler, M. and Thomas, G. H. and Couillin, P. and Junien, C. and McGillivray, B. C. and Hayden, M. and Jaschek, G. and Bruns, G. A. P.

THE SEARCH FOR A DNA MARKER FLANKING THE HUNTINGTONS-DISEASE GENE

Cytogenetics and Cell Genetics

WEBER, B and ROBBINS, C and COLLINS, C and THEILMANN, J and PEDERSON, L and HAYDEN, MR

PERINATAL AND 1ST YEAR FOLLOW-UP OF PATIENTS WITH PRADER-WILLI SYNDROME - NORMAL SIZE OF HANDS AND FEET

Clinical Genetics

CHITAYAT, D and DAVIS, EB and MCGILLIVRAY, BC and HAYDEN, MR and HALL, JG

METHYLATION AT THE D4S95 LOCUS AND PREDICTIVE TESTING

American Journal of Human Genetics

THEILMANN, JL and ROBBINS, CA and HAYDEN, MR

Familial lipoprotein lipase deficiency

Atherosclerosis VIII: proceedings of the 8th International Symposium on Atherosclerosis. ICS817

Brunzell, J.D. and Auwerk, J.H. and Babirak, S.P. and Deeb, S. and Fujimoto, W.Y. and Hayden, M.R.

A deletion map of the WAGR region on chromosome 11

American Journal of Human Genetics

Gessler, M. and Thomas, G.H. and Couillin, P. and Junien, C. and McGillivray, B.C. and Hayden, M. and Jaschek, G. and Bruns, G.A.P.

Silent periods, long-latency reflexes and cortical MEPs in Huntington's desease and at-risk relatives

Electroencephalography and Clinical Neurophysiology/ Evoked Potentials

Eisen, A. and Bohlega, S. and Bloch, M. and Hayden, M.

Predictive testing for Huntington disease: I. Description of a pilot project in British Columbia

American Journal of Medical Genetics

Fox, S. and Bloch, M. and Fahy, M. and Hayden, M.R.

Methylation at the D4S95 locus and predictive testing.

American Journal of Human Genetics

Theilmann, J.L. and Robbins, C.A. and Hayden, M.R.

ELECTROPHYSIOLOGIC PREDICTIVE TESTING IN HUNTINGTONS-DISEASE

Muscle & Nerve

Eisen, A. A. and Bohlega, S. and Bloch, M. and Hayden, M.

Marfan's syndrome.

CMAJ : Canadian Medical Association journal = journal de l"Association medicale canadienne

Gilchrist, D.M. and Hayden, M.R.

FAMILIAL HYPOALPHALIPOPROTEINEMIA (FHA) IS NOT CAUSED BY A DEFECT IN THE GENE FOR APOLIPOPROTEIN AI (APO AI)

Thrombosis and Haemostasis

KASTELEIN, JJP and HAYDEN, MR

THE GENETIC-ASPECTS OF ATHEROSCLEROSIS AND HYPERLIPIDEMIA

Canadian Medical Association Journal

HAYDEN, MR

Perinatal and first year follow-up of patients with Prader-Willi syndrome: normal size of hands and feet

Clinical Genetics

Chitayat, D. and Davis, E.B. and McGillivray, B.C. and Hayden, M.R. and Hall, J.G.

Different options for prenatal testing for Huntington's disease using DNA probes

Journal of Medical Genetics

Fahy, M. and Robbins, C. and Bloch, M. and Turnell, R.W. and Hayden, M.R.

ARTHROGRYPOSIS, FACIAL DYSMORPHISM, HYPOPITUITARISM AND MENTAL-RETARDATION - A NEW SYNDROME

Pediatric Research

CHITAVAT, D and HALL, JG and PHANG, MS and GILCHRIST, D and COUCH, RM and HAYDEN, MR

Predictive testing for Huntington disease: II. Demographic characteristics, life-style patterns, attitudes, and psychosocial assessments of the first fifty-one test candidates

American Journal of Medical Genetics

Bloch, M. and Fahy, M. and Fox, S. and Hayden, M.R.

Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene

Journal of Medical Genetics

Ann, J.T. and Kanani, S. and Shiang, R. and Robbins, C. and Quarrell, O. and Huggins, M. and Hedrick, A. and Weber, B. and Collins, C. and Wasmuth, J.J. and Buetow, K.H. and Murray, J.C. and Hayden, M.R.

The genetic aspects of atherosclerosis and hyperlipidemia

CMAJ

Hayden, M.R.

MARFANS-SYNDROME

Canadian Medical Association Journal

GILCHRIST, DM and HAYDEN, MR

A highly polymorphic locus very tightly linked to the Huntington's disease gene

Nature

Wasmuth, J.J. and Hewitt, J. and Smith, B. and Allard, D. and Haines, J.L. and Skarecky, D. and Partlow, E. and Hayden, M.R.

A COMPOUND HETEROZYGOTE FOR LIPOPROTEIN-LIPASE DEFICIENCY CAUSED BY 2 DISTINCT MAJOR STRUCTURAL REARRANGEMENTS IN THE LIPOPROTEIN-LIPASE GENE

Clinical Research

HAYDEN, MR and LANGLOIS, S and PERITZ, L and KASTELEIN, J and DEEB, S and FAILAR, RA and BRUNZELL, J

PSYCHIATRIC MORBIDITY ASSOCIATED WITH EARLY CLINICAL-DIAGNOSIS OF HUNTINGTON DISEASE IN A PREDICTIVE TESTING PROGRAM

Journal of Clinical Psychiatry

LAM, RW and BLOCH, M and JONES, BD and MARCUS, AM and FOX, S and AMMAN, W and HAYDEN, MR

CHARACTERIZATION OF 6 PARTIAL DELETIONS IN THE LOW-DENSITY-LIPOPROTEIN (LDL) RECEPTOR GENE CAUSING FAMILIAL HYPERCHOLESTEROLEMIA (FH)

American Journal of Human Genetics

LANGLOIS, S and KASTELEIN, JJP and HAYDEN, MR

Psychiatric morbidity associated with early clinical diagnosis of Huntington disease in a predictive testing program

Journal of Clinical Psychiatry

Lam, R.W. and Bloch, M. and Jones, B.D. and Marcus, A.M. and Fox, S. and Amman, W. and Hayden, M.R.

PREDICTIVE TESTING FOR HUNTINGTONS-DISEASE USING LINKED DNA MARKERS

New England Journal of Medicine

HAYDEN, MR and BLOCH, M and FAHY, M

IMPROVED PREDICTIVE TESTING FOR HUNTINGTON DISEASE BY USING 3 LINKED DNA MARKERS

American Journal of Human Genetics

HAYDEN, MR and ROBBINS, C and ALLARD, D and HAINES, J and FOX, S and WASMUTH, J and FAHY, M and BLOCH, M

Comparison of gemfibrozil and clofibrate on serum lipids in familial combined hyperlipidemia. A randomized placebo-controlled, double-blind, crossover clinical trial

Atherosclerosis

Rabkin, S.W. and Hayden, M. and Frohlich, J.

Sequence and expression of Tangier apoA-I gene

European Journal of Biochemistry

MAKRIDES, S.C. and RUIZ?OPAZO, N. and HAYDEN, M. and NUSSBAUM, A.L. and BRESLOW, J.L. and ZANNIS, V.I.

Prenatal diagnosis of asplenia/polysplenia syndrome

American Journal of Obstetrics and Gynecology

Chitayat, D. and Lao, A. and Wilson, R.D. and Fagerstrom, C. and Hayden, M.

Characterization of six partial deletions in the low-density-lipoprotein (LDL) receptor gene causing familial hypercholesterolemia (FH)

American Journal of Human Genetics

Langlois, S. and Kastelein, J.J.P. and Hayden, M.R.

PRESYMPTOMATIC NEUROPSYCHOLOGICAL IMPAIRMENT IN HUNTINGTONS-DISEASE

Archives of Neurology

JASON, GW and PAJURKOVA, EM and SUCHOWERSKY, O and HEWITT, J and HILBERT, C and REED, J and HAYDEN, MR

Predictive Testing for Huntington's Disease Using Linked DNA Markers

New England Journal of Medicine

Hayden, M.R. and Bloch, M. and Fahy, M. and Myers, R.H. and Farrer, L.A. and Gusella, J.F. and Martin, J.B.

PREDICTIVE TESTING FOR HUNTINGTON DISEASE USING LINKED DNA MARKERS

Clinical Research

HAYDEN, MR and ALLARD, D and HAINES, J and HILBERT, C and ROBBINS, C and HEWITT, J and FOX, SL and BLOCH, M

Improved predictive testing for Huntington disease by using three linked DNA markers

American Journal of Human Genetics

Hayden, M.R. and Robbins, C. and Allard, D. and Haines, J. and Fox, S. and Wasmuth, J. and Fahy, M. and Bloch, M.

A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene

American Journal of Human Genetics

Hayden, M.R. and Hewitt, J. and Wasmuth, J.J. and Kastelein, J.J. and Langlois, S. and Conneally, M. and Haines, J. and Smith, B. and Hilbert, C. and Allard, D.

Presymptomatic Neuropsychological Impairment in Huntington's Disease

Archives of Neurology

Jason, G.W. and Pajurkova, E.M. and Suchowersky, O. and Hewitt, J. and Hilbert, C. and Reed, J. and Hayden, M.R.

PRENATAL-DIAGNOSIS OF ASPLENIA POLYSPLENIA SYNDROME

American Journal of Obstetrics and Gynecology

Chitayat, D. and Lao, A. and Wilson, R. D. and Fagerstrom, C. and Hayden, M.

GLUCOSE METABOLIC PARAMETERS IN THE PET DIAGNOSIS OF HUNTINGTONS-DISEASE

Australian and New Zealand Journal of Medicine

AMMANN, W and FENSKE, T and MARTIN, WRW and HAYDEN, MR and CLARK, C

CEREBRAL GLUCOSE AND DOPA METABOLISM IN MOVEMENT-DISORDERS

Canadian Journal of Neurological Sciences

MARTIN, WRW and HAYDEN, MR

THE COMBINED USE OF POSITRON EMISSION TOMOGRAPHY AND DNA POLYMORPHISMS FOR PRECLINICAL DETECTION OF HUNTINGTONS-DISEASE

Neurology

HAYDEN, MR and HEWITT, J and STOESSL, AJ and CLARK, C and AMMANN, W and MARTIN, WRW

Molecular genetics and Huntington's disease. The South African situation

South African Medical Journal

Hayden, M.R. and Goldblatt, J. and Wallis, G. and Winship, I.M. and Beighton, P.

Apolipoprotein B gene variants are involved in the determination of serum cholesterol levels: a study in normo- and hypelipidaemic individuals

Atherosclerosis

Talmud, P.J. and Barni, N. and Kessling, A.M. and Carlsson, P. and Darnfors, C. and Bjursell, G. and Galton, D. and Wynn, V. and Kirk, H. and Hayden, M.R. and Humphries, S.E.

THE COMBINED USE OF POSITRON EMISSION TOMOGRAPHY AND DNA POLYMORPHISM FOR PRECLINICAL DETECTION OF HUNTINGTON DISEASE

Canadian Journal of Neurological Sciences

HAYDEN, MR and HEWITT, J and STOESSL, AJ and CLARK, C and AMMANN, W and MARTIN, WRW

Interaction of high density lipoprotein with adipocytes in a new patient with Tangier disease

Clinical and Investigative Medicine

Frohlich, J. and Fong, B. and Julien, P. and Despres, J.-P. and Angel, A. and Hayden, M. and McLeod, R. and Chow Ch. and Davison, R.H. and Pritchard, H.

Insufficient evidence to invoke defects in or around the A-I gene as the cause for familial hypoalphahpoproteinemia

Atherosclerosis

Hayden, M.R. and Kastelein, J.J.P. and Langlois, S. and Sidoli, A. and Vergani, C.

Hypoalphalipoproteinemia Resembling Fish Eye Disease

Acta Medica Scandinavica

FROHLICH, J. and HOAG, G. and McLEOD, R. and HAYDEN, M. and GODIN, D.V. and WADSWORTH, L.D. and CRITCHLEY, J.D. and PRITCHARD, P.H.

A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene

Genomics

MacDonald, M.E. and Anderson, M.A. and Gilliam, T.C. and Tranebjaerg, L. and Carpenter, N.J. and Magenis, E. and Hayden, M.R. and Healey, S.T. and Bonner, T.I. and Gusella, J.F.

A polymorphic DNA probe located to human chromosome 4p16 (D4S62)

Nucleic Acids Research

Hayden, M.R. and Hewitt, J. and Maresca, A. and Langlois, S.

STUDIES IN PERSONS AT RISK FOR HUNTINGTONS-DISEASE

New England Journal of Medicine

HAYDEN, MR and HEWITT, J and MARTIN, WRW and CLARK, C and AMMANN, W

GAUCHERS-DISEASE IN THE CAPE COLORED POPULATION OF THE RSA, INCLUDING A FAMILY WITH 5 AFFECTED SIBLINGS

South African Medical Journal

SWART, AL and HESSELING, PB and HAYDEN, MR and LOUW, M and HERBERT, JS

EVIDENCE THAT PARAMYOTONIA CONGENITA IS ALLELIC TO MYOTONIC-DYSTROPHY

Cytogenetics and Cell Genetics

CHITAYAT, D and KASTELEIN, JJP and HAYDEN, MR

1ST-TRIMESTER PRENATAL-DIAGNOSIS FOR HUNTINGTONS-DISEASE WITH DNA PROBES

Lancet

HAYDEN, MR and KASTELEIN, JJP and WILSON, RD and HILBERT, C and HEWITT, J and LANGLOIS, S and FOX, S and BLOCH, M

Studies in Persons at Risk for Huntington's Disease

New England Journal of Medicine

Hayden, M.R. and Hewitt, J. and Martin, W.R.W. and Clark, C. and Ammann, W. and Perlmutter, J.S. and Raichle, M.E. and Seidman, J.D. and Mazziotta, J.C. and Phelps, M.E. and Pahl, J. and Huang, S.-C. and Baxter, L.R. and Hoffman, J.M. and Markham, C.H. and Riege, W.H. and Lanto, A.B. and Wapenski, J.A.

CONTROLLING FOR CEREBRAL ATROPHY IN POSITRON EMISSION TOMOGRAPHY DATA

Journal of Cerebral Blood Flow and Metabolism

Clark, C. and Hayden, M. and Hollenberg, S. and Li, D. and Stoessl, A. J.

Arrested epidermal morphogenesis in three newborn infants with a fatal genetic disorder (restrictive dermopathy)

Journal of Investigative Dermatology

Holbrook, K.A. and Dale, B.A. and Witt, D.R. and Hayden, M.R. and Toriello, H.V.

Preclinical testing in Huntington disease.

American journal of medical genetics

Bloch, M. and Hayden, M.R.

FIRST-TRIMESTER PRENATAL DIAGNOSIS FOR HUNTINGTON'S DISEASE WITH DNA PROBES

The Lancet

Hayden, MichaelR. and Kastelein, JohnJ.P. and Wilson, R.D. and Hilbert, C. and Hewitt, J. and Langlois, S. and Fox, S. and Bloch, M.

Cerebral glucose and dopa metabolism in movement disorders

Canadian Journal of Neurological Sciences

Martin, W.R.W. and Hayden, M.R.

A NEW POLYMORPHIC DNA MARKER (D4S62) WHICH MAPS CLOSE TO THE GENE FOR HUNTINGTON DISEASE

Canadian Journal of Neurological Sciences

HAYDEN, MR and HEWITT, J and HAINES, J and MACLEOD, P and WASMUTH, JJ and LANGLOIS, S and KASTELEIN, J

FURTHER EVIDENCE FOR THE LACK OF HETEROGENEITY OF LINKAGE OF HUNTINGTON DISEASE TO D4S10

Cytogenetics and Cell Genetics

Haines, J. L. and Tanzi, R. and Wexler, N. and Harper, P. S. and Folstein, S. and Cassiman, J. and Myers, R. and Young, A. and Hayden, M. and Falak, A. and Tolosa, E. and Crespi, S. and Dimaio, L. and Holmgren, G. and Anvret, M. and Kanazawa, I. and Gusella, J. F. and Conneally, P. M.

Ethical issues in preclinical testing in Huntington disease: response to Margery Shaw's invited editorial comment.

American journal of medical genetics

Hayden, M.R. and Bloch, M. and Fox, S. and Crauford, D.

Controlling for cerebral atrophy in positron emission tomography data.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Clark, C. and Hayden, M. and Hollenberg, S. and Li, D. and Stoessl, A.J.

A POLYMORPHIC DNA MARKER WHICH REPRESENTS A CONSERVED EXPRESSED SEQUENCE IN THE REGION OF THE HUNTINGTON DISEASE GENE

Cytogenetics and Cell Genetics

HAYDEN, MR and HEWITT, J and WASMUTH, JJ and SMITH, B and LANGLOIS, S and CONNEALLY, PM and HAINES, J and HILBERT, C and KASTELEIN, JP

The combined use of positron emission tomography and DNA polymorphisms for preclinical detection of huntingtons disease

Neurology

Hayden, M.R. and Hewitt, J. and Stoessl, A.J. and Clark, C. and Ammann, W. and Martin, W.R.W.

INTERACTION OF HIGH-DENSITY-LIPOPROTEIN WITH ADIPOCYTES IN A NEW PATIENT WITH TANGIER DISEASE

Clinical and Investigative Medicine-Medecine Clinique Et Experimentale

Frohlich, J. and Fong, B. and Julien, P. and Despres, J. P. and Angel, A. and Hayden, M. and McLeod, R. and Chow, C. and Davison, R. H. and Pritchard, H.

COMBINED POSITRON EMISSION TOMOGRAPHY AND DNA STUDIES MAY IDENTIFY RECOMBINATION BETWEEN THE LINKED MARKER AND THE GENE IN ASYMPTOMATIC INDIVIDUALS AT RISK FOR HUNTINGTONS-DISEASE

Annals of Neurology

MARTIN, WRW and AMMANN, W and CLARK, C and HEWITT, J and HAYDEN, MR

DNA polymorphisms in and around the Apo-A1-CIII genes and genetic hyperlipidemias

American Journal of Human Genetics

Hayden, M.R. and Kirk, H. and Clark, C. and Frohlich, J. and Rabkin, S. and McLeod, R. and Hewitt, J.

Gaucher's disease in the Cape Coloured population of the RSA, including a family with 5 affected siblings

South African Medical Journal

Swart, A.L. and Hesseling, P.B. and Hayden, M.R. and Louw, M. and Herbert, J.S.

MOLECULAR-GENETICS AND HUNTINGTONS-DISEASE - THE SOUTH-AFRICAN SITUATION

South African Medical Journal

HAYDEN, MR and GOLDBLATT, J and WALLIS, G and WINSHIP, IM and BEIGHTON, P

PREDICTIVE STUDIES IN HUNTINGTONS-DISEASE

Neurology

STOESSL, AJ and HAYDEN, MR and MARTIN, WRW and CLARK, C and PATE, BD

Restrictive dermopathy: A newly recognized autosomal recessive skin dysplasia

American Journal of Medical Genetics

Witt, D.R. and Hayden, M.R. and Holbrook, K.A. and Dale, B.A. and Baldwin, V.J. and Taylor, G.P.

Positron emission tomography in the early diagnosis of Huntington's disease

Neurology

Hayden, M.R. and Martin, W.R.W. and Stoessl, A.J. and Clark, C. and Hollenberg, S. and Adam, M.J. and Ammann, W. and Harrop, R. and Rogers, J. and Ruth, T.

Subregional assignment of the linked marker G8 (D4S10) for Huntington disease to chromosome 4p16.1-16.3

American Journal of Human Genetics

Wang, H.S. and Greenberg, C.R. and Hewitt, J. and Kalousek, D. and Hayden, M.R.

A FAMILY WITH HUNTINGTON DISEASE AND RECIPROCAL TRANSLOCATION 4-5

American Journal of Human Genetics

FROSTERISKENIUS, UG and HAYDEN, MR and WANG, HS and KALOUSEK, DK and HORSMAN, D and PFEIFFER, RA and SCHOTTKY, A and SCHWINGER, E

DOPAMINE IN HUNTINGTONS-DISEASE - STUDIES USING POSITRON EMISSION TOMOGRAPHY

Neurology

STOESSL, AJ and MARTIN, WRW and HAYDEN, MR and ADAM, MJ and RUTH, TJ and RAJPUT, A and PATE, BD and CALNE, DB

REGRESSION-MODEL FOR PREDICTING DISSOCIATIONS OF REGIONAL CEREBRAL GLUCOSE-METABOLISM IN INDIVIDUALS AT RISK FOR HUNTINGTONS-DISEASE

Journal of Cerebral Blood Flow and Metabolism

CLARK, CM and HAYDEN, MR and STOESSL, AJ and MARTIN, WRW

Linkage of the G8 Marker on Chromosome 4 to Huntington's Disease in a Large American Black Family

New England Journal of Medicine

Bird, T.D. and Hewitt, J. and Conneally, P.M. and Hayden, M.R.

POSITRON EMISSION TOMOGRAPHY IN THE EARLY DIAGNOSIS OF HUNTINGTONS-DISEASE

Neurology

HAYDEN, MR and MARTIN, WRW and STOESSL, AJ and CLARK, C and HOLLENBERG, S and ADAM, MJ and AMMANN, W and HARROP, R and ROGERS, J and RUTH, T and SAYRE, C and PATE, BD

LINKAGE OF THE G8 MARKER ON CHROMOSOME-4 TO HUNTINGTONS-DISEASE IN A LARGE AMERICAN BLACK-FAMILY

New England Journal of Medicine

BIRD, TD and HEWITT, J and CONNEALLY, PM and HAYDEN, MR

EFFECT OF POWER ON THE THERMAL REGIME IN AN EB HEARTH.

Tripp, D. and Mitchell, A. and Hayden, M.

Cerebral metabolism of glucose in benign hereditary chorea

Movement Disorders

Suchowersky, O. and Hayden, M.R. and Martin, W.R.W. and Stoessl, A.J. and Hildebrand, A.M. and Pate, B.D.

A family with Huntington disease and reciprocal translocation 4;5

American Journal of Human Genetics

Froster-Iskenius, U.G. and Hayden, M.R. and Kalousek, D.K.

The genetics and molecular biology of apolipoprotein CII.

Advances in Experimental Medicine and Biology

Hayden, M.R. and Vergani, C. and Humphries, S.E. and Kirby, L. and Shukin, R. and McLeod, R.

Regression model for predicting dissociations of regional cerebral glucose metabolism in individuals at risk for Huntington's disease

Journal of Cerebral Blood Flow and Metabolism

Clark, C.M. and Hayden, M.R. and Stoessl, A.J. and Martin, W.R.W.

Primary lipoprotein lipase deficiency.

Advances in experimental medicine and biology

Brunzell, J.D. and Iverius, P.H. and Scheibel, M.S. and Fujimoto, W.Y. and Hayden, M.R. and McLeod, R. and Frolich, J.

PRECLINICAL DETECTION OF HUNTINGTON DISEASE USING LINKED DNA POLYMORPHIC MARKERS AND POSITRON EMISSION TOMOGRAPHY (PET)

Clinical Research

HAYDEN, MR and WANG, HS and MARTIN, W and GOMEZ, J and WONG, C and ROSS, H and CUDDEFORD, C and TANZI, R and GUSELLA, J

Age of onset in siblings of persons with juvenile Huntinqton disease

Clinical Genetics

Hayden, M.R. and Soles, J.A. and Ward, D.R.H.

LIPID AND LIPOPROTEIN CHARACTERISTICS OF PATIENTS REFERRED TO A LIPID CLINIC

Clinical and Investigative Medicine-Medecine Clinique Et Experimentale

Frohlich, J. and Rabkin, S. W. and Hayden, M. and Lee, C. and Lui, H.

Brief clinical report: bilateral renal agenesis in twins

American Journal of Medical Genetics

Wilson, R.D. and Hayden, M.R.

Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome

Nature

Gusella, J.F. and Tanzi, R.E. and Bader, P.I. and Phelan, M.C. and Stevenson, R. and Hayden, M.R. and Hofman, K.J. and Faryniarz, A.G. and Gibbons, K.

PET STUDIES OF GLUCOSE-METABOLISM IN HUNTINGTONS-DISEASE

Canadian Journal of Neurological Sciences

STOESSL, AJ and HAYDEN, MR and MARTIN, WRW and CLARK, C and PATE, BD

AGE OF ONSET IN SIBLINGS OF PERSONS WITH JUVENILE HUNTINGTON DISEASE

Clinical Genetics

HAYDEN, MR and SOLES, JA and WARD, RH

Urinary proteins in a patient with Tangier disease

Clinical Biochemistry

Pritchard, P.H. and Bergseth, M. and McLeod, R. and Hayden, M.R. and Frohlich, J.

SUBREGIONAL ASSIGNMENT OF THE LINKED MARKER D4S10 (G8) FOR HUNTINGTON DISEASE BY INSITU HYBRIDIZATION

Cytogenetics and Cell Genetics

WANG, HS and GREENBERG, CR and KALOUSEK, D and GUSELLA, J and HORSMAN, D and HAYDEN, MR

DELETION OF THE HUNTINGTONS DISEASE-LINKED D4S10 LOCUS IN WOLF-HIRSCHHORN SYNDROME

Cytogenetics and Cell Genetics

Gusella, J. and Tanzi, R. and Gibbons, K. and Faryniarz, A. and Phelan, M. and Stevenson, R. and Bader, P. and Hayden, M. and Hofman, K. and Hobbs, W. and Anderson, M.

Bilateral renal agenesis in twins.

American Journal of Medical Genetics - Seminars in Medical Genetics

Wilson, R.D. and Hayden, M.R.

STRIATAL METABOLISM IN HUNTINGTONS-DISEASE AND IN BENIGN HEREDITARY CHOREA

Annals of Neurology

MARTIN, WRW and HAYDEN, MR and SUCHOWERSKY, O and BECKMAN, J and ADAM, M and AMMANN, W and BERGSTROM, M and HARROP, R and ROGERS, J and RUTH, T and SAYRE, C and PATE, BD

PLASMA LCAT AND RED-BLOOD-CELL MEMBRANE-COMPOSITION IN TANGIER DISEASE

Clinical Research

FROHLICH, J and HAYDEN, MR and MCLEOD, R and GODIN, D

POSITRON EMISSION TOMOGRAPHY IN THE STUDY OF DISORDERS OF THE BASAL GANGLIA

Canadian Journal of Neurological Sciences

Martin, W. R. W. and Hayden, M. and Calne, D. B. and Beckman, J. and Bergstrom, M. and Harrop, R. and Sayre, C. and Pate, B. D. and Adams, M. and Ruth, T. and Rogers, J.

BENIGN HEREDITARY CHOREA - CLINICAL, RADIOLOGICAL AND PET FINDINGS

Canadian Journal of Neurological Sciences

Suchowersky, O. and Hayden, M. and Martin, W. R. W. and Li, D. K. and Bergstrom, M. and Marrop, R. and Rogers, J. and Sayre, C. and Pate, B. D.

MOLECULAR GENETIC APPROACHES TO THE STUDY OF THE NERVOUS-SYSTEM

Developmental Neuroscience

HAYDEN, MR and NICHOLS, JL

A RISK CURVE FOR COUNSELING ASYMPTOMATIC SIBLINGS OF PERSONS WITH JUVENILE ONSET HUNTINGTON DISEASE

Clinical Research

SOLES, J and HAYDEN, MR

Down's syndrome and Alzheimer's disease

Annals of Neurology

Suchowersky, O. and Hayden, M.

IS PROAPOLIPOPROTEIN-A-I EXCRETED IN URINE OF A PATIENT WITH TANGIER DISEASE

American Journal of Human Genetics

Frohlich, J. and McLeod, R. and Pritchard, H. and Urquhart, N. and Hayden, M.

Reflections on the history of Huntington's chorea

Trends in Neurosciences

Hayden, M.R.

Molecular genetic approaches to the study of the nervous system

Developmental Neuroscience

Hayclen, M.R. and Nichols, J.L.

The high frequency of juvenile Huntington's chorea in South Africa

Journal of Medical Genetics

Hayden, M.R. and MacGregor, J.M. and Saffer, D.S. and Beighton, P.H.

Genetic aspects of Huntington's chorea: Results of a national survey

American Journal of Medical Genetics

Hayden, M.R. and Beighton, P.

THE HIGH-FREQUENCY OF JUVENILE HUNTINGTONS-CHOREA IN SOUTH-AFRICA

Journal of Medical Genetics

HAYDEN, MR and MACGREGOR, JM and SAFFER, DS and BEIGHTON, PH

Huntington's chorea on the island of Mauritius.

South African Medical Journal

Hayden, M.R. and Berkowicz, A.L. and Beighton, P.H. and Yiptong, C.

HUNTINGTONS-CHOREA

South African Medical Journal

BEIGHTON, P and HAYDEN, MR

Huntington's chorea.

South African Medical Journal

Beighton, P. and Hayden, M.R.

ON THE HIGH-FREQUENCY OF PATRILINEAL DESCENT AND FAMILIAL AGGREGATION IN JUVENILE HUNTINGTONS-DISEASE

American Journal of Human Genetics

HAYDEN, MR and BEIGHTON, PH

HUNTINGTONS-CHOREA ON THE ISLAND OF MAURITIUS

South African Medical Journal

HAYDEN, MR and BERKOWICZ, AL and BEIGHTON, PH and YIPTONG, C

THE ORIGIN OF HUNTINGTONS-CHOREA IN THE AFRIKANER POPULATION OF SOUTH-AFRICA

South African Medical Journal

HAYDEN, MR and HOPKINS, HC and MACRAE, M and BEIGHTON, PH

The origin of Huntington's chorea in the Afrikaner population of South Africa

South African Medical Journal

Hayden, M.R. and Hopkins, H.C. and Macrae, M. and Beighton, P.H.

THE PREVALENCE OF HUNTINGTONS-CHOREA IN SOUTH-AFRICA

South African Medical Journal

HAYDEN, MR and MACGREGOR, JM and BEIGHTON, PH

The prevalence of Huntington's chorea in South Africa

South African Medical Journal

Hayden, M.R. and MacGregor, J.M. and Beighton, P.H.

Social perspectives in Huntington's chorea

South African Medical Journal

Hayden, M.R. and Ehrlich, R. and Parker, H. and Ferera, S.J.

SOCIAL PERSPECTIVES IN HUNTINGTONS-CHOREA

South African Medical Journal

HAYDEN, MR and EHRLICH, R and PARKER, H and FERERA, SJ

The fetal hydantoin syndrome. A case report

South African Medical Journal

Hayden, M.

The fetal alcohol syndrome

South African Medical Journal

Hayden, M.R. and Nelson, M.M.

FETAL ALCOHOL SYNDROME

South African Medical Journal

HAYDEN, MR and NELSON, MM

Q fever endocarditis. A report of 2 cases

South African Medical Journal

Rosman, M.S. and Lubbe, W.F. and Hayden, M. and Basson, N. and Uys, C.J.

IMPAIRED PROLACTIN RELEASE IN HUNTINGTON'S CHOREA. EVIDENCE FOR DOPAMINERGIC EXCESS

The Lancet

Hayden, M.R. and Paul, M. and Vinik, A.I. and Beighton, P.

HUNTINGTONS-CHOREA IN CAPE COLORED COMMUNITY OF SOUTH-AFRICA

South African Medical Journal

HAYDEN, MR and BEIGHTON, P

Huntington's chorea in the Cape Coloured community of South Africa

South African Medical Journal

Hayden, M.R. and Beighton, P.