Overview

Dr. Hayden’s work focuses on understanding the genetic roots of illness and using that understanding to develop better approaches to treatment for patients. He researches diabetes, coronary artery disease, and is part of a large collaboration to determine the genetic basis for adverse drug reactions. Much of his career has also been dedicated to understanding the development of Huntington disease and finding a way to cure it.

Publications

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer
Jama Oncology
Drogemoller, B. I. and Monzon, J. G. and Bhavsar, A. P. and Borrie, A. E. and Brooks, B. and Wright, G. E. B. and Liu, G. and Renouf, D. J. and Kollmannsberger, C. K. and Bedard, P. L. and Aminkeng, F. and Amstutz, U. and Hildebrand, C. A. and Gunaretnam, E. P. and Critchley, C. and Chen, Z. and Brunham, L. R. and Hayden, M. R. and Ross, C. J. D. and Gelmon, K. A. and Carleton, B. C.
DOI: 10.1001/jamaoncol.2017.0502
11/2017

Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models
Molecular Neurobiology
Naia, L. and Rosenstock, T. R. and Oliveira, A. M. and Oliveira-Sousa, S. I. and Caldeira, G. L. and Carmo, C. and Laco, M. N. and Hayden, M. R. and Oliveira, C. R. and Rego, A. C.
DOI: 10.1007/s12035-016-0048-3
09/2017

Reduction of mutant huntingtin in oligodendroglia rescues myelination and behavioural deficits in a model of Huntington disease
Journal of Neurochemistry
Bardile, C. F. and Garcia-Miralles, M. and Caron, N. and Teo, R. and Hayden, M. R. and Pouladi, M. A.
08/2017

AUTHOR RESPONSE: HUNTINGTON DISEASE REDUCED PENETRANCE ALLELES OCCUR AT HIGH FREQUENCY IN THE GENERAL POPULATION
Neurology
Hayden, M. R. and Kay, C.
DOI: 10.1212/wnl.0000000000003528
05/2017

A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis
Genome Medicine
Ross, C. J. and Towfic, F. and Shankar, J. and Laifenfeld, D. and Thoma, M. and Davis, M. and Weiner, B. and Kusko, R. and Zeskind, B. and Knappertz, V. and Grossman, I. and Hayden, M. R.
DOI: 10.1186/s13073-017-0436-y
05/2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer
British Journal of Clinical Pharmacology
Aminkeng, F. and Ross, C. J. D. and Rassekh, S. R. and Rieder, M. J. and Bhavsar, A. P. and Sanatani, S. and Bernstein, D. and Hayden, M. R. and Amstutz, U. and Carleton, B. C.
DOI: 10.1111/bcp.13218
03/2017

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
Journal of Neuroscience
Naia, L. and Cunha-Oliveira, T. and Rodrigues, J. and Rosenstock, T. R. and Oliveira, A. and Ribeiro, M. and Carmo, C. and Oliveira-Sousa, S. I. and Duarte, A. I. and Hayden, M. R. and Rego, A. C.
DOI: 10.1523/jneurosci.2006-14.2016
03/2017

Palmitoylation of caspase-6 by HIP14 regulates its activation
Cell Death and Differentiation
Skotte, N. H. and Sanders, S. S. and Singaraja, R. R. and Ehrnhoefer, D. E. and Vaid, K. and Qiu, X. F. and Kannan, S. and Verma, C. and Hayden, M. R.
DOI: 10.1038/cdd.2016.139
01/2017

eEF2K inhibition blocks A beta 42 neurotoxicity by promoting an NRF2 antioxidant response
Acta Neuropathologica
Jan, A. and Jansonius, B. and Delaidelli, A. and Somasekharan, S. P. and Bhanshali, F. and Vandal, M. and Negri, G. L. and Moerman, D. and MacKenzie, I. and Calon, F. and Hayden, M. R. and Taubert, S. and Sorensen, P. H.
DOI: 10.1007/s00401-016-1634-1
01/2017

The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America
European Journal of Human Genetics
Kay, C. and Tirado-Hurtado, I. and Cornejo-Olivas, M. and Collins, J. A. and Wright, G. and Inca-Martinez, M. and Veliz-Otani, D. and Ketelaar, M. E. and Slama, R. A. and Ross, C. J. and Mazzetti, P. and Hayden, M. R.
DOI: 10.1038/ejhg.2016.169
01/2017

A novel humanizedmouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Human Molecular Genetics
Southwell, A. L. and Skotte, N. H. and Villanueva, E. B. and Ostergaard, M. E. and Gu, X. F. and Kordasiewicz, H. B. and Kay, C. and Cheung, D. and Xie, Y. Y. and Waltl, S. and Dal Cengio, L. and Findlay-Black, H. and Doty, C. N. and Petoukhov, E. and Iworima, D. and Slama, R. and Ooi, J. and Pouladi, M. A. and Yang, X. W. and Swayze, E. E. and Seth, P. P. and Hayden, M. R.
DOI: 10.1093/hmg/ddx021
01/2017

Reduction of mutant huntingtin in oligodendroglia rescues myelination and behavioural deficits in a model of Huntington disease
Journal of Neurochemistry
Bardile, C. F. and Garcia-Miralles, M. and Caron, N. and Teo, R. and Hayden, M. R. and Pouladi, M. A.
2017

NEURODEGENERATION Role of repeats in protein clearance
Nature
Martin, D. D. O. and Hayden, M. R.
2017

Evaluation of pridopidine in the transgenic YAC128 mouse model of Huntington disease
Journal of Neurochemistry
Garcia-Miralles, M. and Yosuf, Nabm and Tan, J. Y. and Kusko, R. and Tan, L. J. and Xu, X. and Orbach, A. and Geva, M. and Hayden, M. R. and Pouladi, M. A.
2017

Beyond Motor Effects-Pridopidine's New Therapeutic Potential
Neurotherapeutics
Geva, M. and Kusko, R. and Ryskamp, D. and Bezprozvanny, I. and Grossman, I. and Orbach, A. and Burczynski, M. and Papapetropoulos, S. and Laufer, R. and Hayden, M. R.
2017

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD
Human Molecular Genetics
Riechers, S. P. and Butland, S. and Deng, Y. and Skotte, N. and Ehrnhoefer, D. E. and Russ, J. and Laine, J. and Laroche, M. and Pouladi, M. A. and Wanker, E. E. and Hayden, M. R. and Graham, R. K.
DOI: 10.1093/hmg/ddw036
2016

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin
Neuropeptides
Naia, L. and Ribeiro, M. and Rodrigues, J. and Duarte, A. I. and Lopes, C. and Rosenstock, T. R. and Hayden, M. R. and Rego, A. C.
DOI: 10.1016/j.npep.2016.01.009
2016

Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells
Journal of Neurochemistry
Dobson, L. and Trager, U. and Farmer, R. R. and Hayardeny, L. and Loupe, P. and Hayden, M. R. and Tabrizi, S. J.
DOI: 10.1111/jnc.13553
2016

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
Scientific Reports
Garcia-Miralles, M. and Hong, X. and Tan, L. J. and Caron, N. S. and Huang, Y. H. and To, X. V. and Lin, R. Y. and Franciosi, S. and Papapetropoulos, S. and Hayardeny, L. and Hayden, M. R. and Chuang, K. H. and Pouladi, M. A.
DOI: 10.1038/srep31652
2016

MITIGATE-HD: A Trial of Memantine in Huntington Disease
Neurotherapeutics
Petkau, T. and Sturrock, A. and Coleman, A. and Mackay, A. and Russell-Schulz, B. and Langbehn, D. and Hayden, M. R. and Leavitt, B. R.
2016

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes
Scientific Reports
Maillet, A. and Tan, K. and Chai, X. R. and Sadananda, S. N. and Mehta, A. and Ooi, J. and Hayden, M. R. and Pouladi, M. A. and Ghosh, S. and Shim, W. and Brunham, L. R.
DOI: 10.1038/srep25333
2016

Pharmacogenomic Strategies for the Prevention of Anthracycline-Induced Heart Failure: Validation of a Genetic Association with a Non-Synonymous Variant in RARG
Pediatric Blood & Cancer
Bhavsar, A. P. and Rassekh, S. R. and Aminkeng, F. and Li, Y. and Gunaretnam, E. and Rieder, M. J. and Bernstein, D. and Hayden, M. R. and Carleton, B. C. and Ross, C. J. D.
2016

Pridopidine activates neuroprotective pathways impaired in Huntington Disease
Human Molecular Genetics
Geva, M. and Kusko, R. and Soares, H. and Fowler, K. D. and Birnberg, T. and Barash, S. and Merenlender-Wagner, A. and Fine, T. and Lysaght, A. and Weiner, B. and Cha, Y. and Kolitz, S. and Towfic, F. and Orbach, A. and Laufer, R. and Zeskind, B. and Grossman, I. and Hayden, M. R.
DOI: 10.1093/hmg/ddw238
2016

Rationale and Design for LEGATO-HD Study: A Multinational, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Laquinimod (0.5, 1.0, and 1.5 mg/day) as Treatment in Patients with Huntington Disease
Neurotherapeutics
Reilmann, R. and Tabrizi, S. and Leavitt, B. and Stout, J. C. and Piccini, P. and Anderson, K. E. and Feigin, A. and Hayden, M. and Grozinski-Wolff, M. and Eyal, E. and Papapetropoulos, S.
2016

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity
British Journal of Clinical Pharmacology
Aminkeng, F. and Ross, C. J. D. and Rassekh, S. R. and Hwang, S. and Rieder, M. J. and Bhavsar, A. P. and Smith, A. and Sanatani, S. and Gelmon, K. A. and Bernstein, D. and Hayden, M. R. and Amstutz, U. and Carleton, B. C. and Cpnds Clin Practice
DOI: 10.1111/bcp.13008
2016

Similarities and differences in the gene expression profiles of copaxone and polimunol
Multiple Sclerosis Journal
Laifenfeld, D. and Hasson, T. and Kolitz, S. E. and Fowler, K. D. and Konya, A. and Bakshi, S. and Zeskind, B. and Grossman, I. and Hayden, M. R.
2016

Similarities and differences in the gene expression profiles of glatopa and copaxone
Multiple Sclerosis Journal
Kolitz, S. and Laifenfeld, D. and Fowler, K. and Hasson, T. and Konya, A. and Bakshi, S. and Zeskind, B. and Grossman, I. and Hayden, M. R.
2016

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease
Human Molecular Genetics
Teo, R. T. Y. and Hong, X. and Yu-Taeger, L. and Huang, Y. H. and Tan, L. J. and Xie, Y. Y. and To, X. V. and Guo, L. and Rajendran, R. and Novati, A. and Calaminus, C. and Riess, O. and Hayden, M. R. and Nguyen, H. P. and Chuang, K. H. and Pouladi, M. A.
DOI: 10.1093/hmg/ddw122
2016

Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice
Bmc Biology
Sanders, S. S. and Parsons, M. P. and Mui, K. K. N. and Southwell, A. L. and Franciosi, S. and Cheung, D. and Waltl, S. and Raymond, L. A. and Hayden, M. R.
DOI: 10.1186/s12915-016-0333-7
2016

The Aryl Hydrocarbon Receptor in the Peripheral Immune System is the Molecular Target of Laquinimod in MOG induced Experimental Autoimmune Encephalomyelitis
Multiple Sclerosis Journal
Kaye, J. and Birnberg, T. and Hingaly, T. and Raymond, E. and Piryatinsky, V. and Caballero, I. and Orbach, A. and Grossman, I. and Knappertz, V. and Hayden, M. R. and Laufer, R.
2016

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease
Experimental Neurology
Garcia-Miralles, M. and Ooi, J. and Bardile, C. F. and Tan, L. J. and George, M. and Drum, C. L. and Lin, R. Y. and Hayden, M. R. and Pouladi, M. A.
DOI: 10.1016/j.expneurol.2016.01.019
2016

A novel microdeletion affecting the CETP gene raises HDL-associated cholesterol levels
Clinical Genetics
Hitchcock, E. and Patankar, J. V. and Tyson, C. and Hrynchak, M. and Hayden, M. R. and Gibson, W. T.
DOI: 10.1111/cge.12633
2016

A TRUE MENTOR AND PIONEER IN MEDICAL GENETICS
Samj South African Medical Journal
Hayden, M. R.
DOI: 10.7196/SAMJ.2016.v106i6.11022
2016

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice
Diabetologia
Wijesekara, N. and Kaur, A. and Westwell-Roper, C. and Nackiewicz, D. and Soukhatcheva, G. and Hayden, M. R. and Verchere, C. B.
DOI: 10.1007/s00125-016-3907-6
2016

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes
Human Molecular Genetics
Southwell, A. L. and Smith-Dijak, A. and Kay, C. and Sepers, M. and Villanueva, E. B. and Parsons, M. P. and Xie, Y. Y. and Anderson, L. and Felczak, B. and Waltl, S. and Ko, S. and Cheung, D. and Dal Cengio, L. and Slama, R. and Petoukhov, E. and Raymond, L. A. and Hayden, M. R.
DOI: 10.1093/hmg/ddw212
2016

Anti-SEMA4D Antibody Ameliorates Pathogenic Processes in Central Nervous System, Cognitive Impairment in the YAC128 Mouse Model of Huntington Disease, and is Well-tolerated in Patients
Neurotherapeutics
Zauderer, M. and Klimatcheva, E. and Fisher, T. and Reilly, C. and Winter, L. and Mallow, C. and Bussler, H. and Torno, S. and Howell, A. and Scrivens, M. and Balch, L. and Wang, W. and Paris, M. and Evans, E. and Southwell, A. and Hayden, M. and Leonard, J. and Smith, E.
2016

Association of a multi-SNP signature with response to copaxone (Glatiramer Acetate) in a subset of patients and in multiple RRMS patient cohorts
Multiple Sclerosis Journal
Ross, C. and Towfic, F. and Shankar, J. and Laifenfeld, D. and Davies, M. and Thoma, M. and Zeskind, B. and Knappertz, V. and Grossman, I. and Hayden, M. R.
2016

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease
Molecular Therapy-Nucleic Acids
Miniarikova, J. and Zanella, I. and Huseinovic, A. and van der Zon, T. and Hanemaaijer, E. and Martier, R. and Koornneef, A. and Southwell, A. L. and Hayden, M. R. and van Deventer, S. J. and Petry, H. and Konstantinova, P.
DOI: 10.1038/mtna.2016.7
2016

Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study
Brain
Masellis, M. and Collinson, S. and Freeman, N. and Tampakeras, M. and Levy, J. and Tchelet, A. and Eyal, E. and Berkovich, E. and Eliaz, R. E. and Abler, V. and Grossman, I. and Fitzer-Attas, C. and Tiwari, A. and Hayden, M. R. and Kennedy, J. L. and Lang, A. E. and Knight, J. and Adagio Investigators
DOI: 10.1093/brain/aww109
2016

ENHANCED IMMUNE RESPONSE TO MMP3 STIMULATION IN MICROGLIA EXPRESSING MUTANT HUNTINGTIN
Neuroscience
Connolly, C. and Magnusson-Lind, A. and Lu, G. and Wagner, P. K. and Southwell, A. L. and Hayden, M. R. and Bjorkqvist, M. and Leavitt, B. R.
DOI: 10.1016/j.neuroscience.2016.03.031
2016

Functional effects of the antigen glatiramer acetate are complex and tightly associated with its composition
Journal of Neuroimmunology
Hasson, T. and Kolitz, S. and Towfic, F. and Laifenfeld, D. and Bakshi, S. and Beriozkin, O. and Shacham-Abramson, M. and Timan, B. and Fowler, K. D. and Birnberg, T. and Konya, A. and Komlosh, A. and Ladkani, D. and Hayden, M. R. and Zeskind, B. and Grossman, I.
DOI: 10.1016/j.jneuroim.2015.11.020
2016

Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics
Pharmacogenetics and Genomics
Chan, S. L. and Samaranayake, N. and Ross, C. J. D. and Toh, M. T. and Carleton, B. and Hayden, M. R. and Teo, Y. Y. and Dissanayake, V. H. W. and Brunham, L. R.
DOI: 10.1097/fpc.0000000000000182
2016

Huntington disease reduced penetrance alleles occur at high frequency in the general population
Neurology
Kay, C. and Collins, J. A. and Miedzybrodzka, Z. and Madore, S. J. and Gordon, E. S. and Gerry, N. and Davidson, M. and Slama, R. A. and Hayden, M. R.
2016

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor
Proceedings of the National Academy of Sciences of the United States of America
Kaye, J. and Piryatinsky, V. and Birnberg, T. and Hingaly, T. and Raymond, E. and Kashi, R. and Amit-Romach, E. and Caballero, I. S. and Towfic, F. and Ator, M. A. and Rubinstein, E. and Laifenfeld, D. and Orbach, A. and Shinar, D. and Marantz, Y. and Grossman, I. and Knappertz, V. and Hayden, M. R. and Laufer, R.
DOI: 10.1073/pnas.1607843113
2016

A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Nature Genetics
Aminkeng, F. and Bhavsar, A. P. and Visscher, H. and Rassekh, S. R. and Li, Y. L. and Lee, J. W. and Brunham, L. R. and Caron, H. N. and van Dalen, E. C. and Kremer, L. C. and van der Pal, H. J. and Amstutz, U. and Rieder, M. J. and Bernstein, D. and Carleton, B. C. and Hayden, M. R. and Ross, C. J. D. and Canadian Pharmacogenomics, Network
DOI: 10.1038/ng.3374
2015

CODEINE-RELATED DEATHS IN ONTARIO, CANADA: THE ROLE OF PHARMACOGENETICS AND DRUG INTERACTIONS
Clinical Pharmacology & Therapeutics
Lam, J. and Woodall, K. and Solbeck, P. and Ross, C. J. and Carleton, B. C. and Hayden, M. R. and Koren, G. and Madadi, P.
2014

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease
Human Molecular Genetics
Butland, S. L. and Sanders, S. S. and Schmidt, M. E. and Riechers, S. P. and Lin, D. T. S. and Martin, D. D. O. and Vaid, K. and Graham, R. K. and Singaraja, R. R. and Wanker, E. E. and Conibear, E. and Hayden, M. R.
DOI: 10.1093/hmg/ddu137
2014

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
Proceedings of the National Academy of Sciences of the United States of America
Rotblat, B. and Southwell, A. L. and Ehrnhoefer, D. E. and Skotte, N. H. and Metzler, M. and Franciosi, S. and Leprivier, G. and Somasekharan, S. P. and Barokas, A. and Deng, Y. and Tang, T. and Mathers, J. and Cetinbas, N. and Daugaard, M. and Kwok, B. and Li, L. H. and Carnie, C. J. and Fink, D. and Nitsch, R. and Galpin, J. D. and Ahern, C. A. and Melino, G. and Penninger, J. M. and Hayden, M. R. and Sorensen, P. H.
DOI: 10.1073/pnas.1314421111
2014

Multisource Ascertainment of Huntington Disease in Canada: Prevalence and Population at Risk
Movement Disorders
Fisher, E. R. and Hayden, M. R.
DOI: 10.1002/mds.25717
2014

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin
Human Molecular Genetics
Ehrnhoefer, D. E. and Skotte, N. H. and Ladha, S. and Nguyen, Y. T. N. and Qiu, X. F. and Deng, Y. and Huynh, K. T. and Engemann, S. and Nielsen, S. M. and Becanovic, K. and Leavitt, B. R. and Hasholt, L. and Hayden, M. R.
DOI: 10.1093/hmg/ddt458
2014

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity
Clinical Pharmacology & Therapeutics
Carleton, B. C. and Ross, C. J. and Bhavsar, A. P. and Amstutz, U. and Pussegoda, K. and Visscher, H. and Lee, J. W. and Brooks, B. and Rassekh, S. R. and Dube, M. P. and Hayden, M. R.
DOI: 10.1038/clpt.2013.219
2014

ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity
Journal of Lipid Research
de Haan, W. and Bhattacharjee, A. and Ruddle, P. and Kang, M. H. and Hayden, M. R.
DOI: 10.1194/jlr.M045294
2014

Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin
Journal of Biological Chemistry
Parsons, M. P. and Kang, R. J. and Buren, C. and Dau, A. and Southwell, A. L. and Doty, C. N. and Sanders, S. S. and Hayden, M. R. and Raymond, L. A.
DOI: 10.1074/jbc.M113.513945
2014

Codeine-related deaths: The role of pharmacogenetics and drug interactions
Forensic Science International
Lama, J. and Woodall, K. L. and Solbeck, P. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R. and Koren, G. and Madadi, P.
DOI: 10.1016/j.forsciint.2014.03.018
2014

Elevated cytokine release in microglia from Huntington's disease mice is reversed by laquinimod
Movement Disorders
Leavitt, B. R. and Connolly, C. and Wagner, P. K. and Hayardeny, L. and Hayden, M. R.
2014

Evidence-based genetic counselling implications for Huntington disease intermediate allele predictive test results
Clinical Genetics
Semaka, A. and Hayden, M. R.
DOI: 10.1111/cge.12324
2014

Examining conditional caspase-6 deficiency as a therapeutic in Huntington's disease
Movement Disorders
Ladha, S. and Wong, B. K. Y. and Hayden, M. R.
2014

Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent
Pharmacogenomics Journal
Aminkeng, F. and Ross, C. J. D. and Rassekh, S. R. and Brunham, L. R. and Sistonen, J. and Dube, M. P. and Ibrahim, M. and Nyambo, T. B. and Omar, S. A. and Froment, A. and Bodo, J. M. and Tishkoff, S. and Carleton, B. C. and Hayden, M. R. and Canadian Pharmacogenomics, Network
DOI: 10.1038/tpj.2013.13
2014

Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of Huntingtin
Human Molecular Genetics
Martin, D. D. O. and Heit, R. J. and Yap, M. C. and Davidson, M. W. and Hayden, M. R. and Berthiaume, L. G.
DOI: 10.1093/hmg/ddu027
2014

Identification of Binding Sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L
Plos One
Sanders, S. S. and Mui, K. K. N. and Sutton, L. M. and Hayden, M. R.
DOI: 10.1371/journal.pone.0090669
2014

Laquinimod reduces neuronal caspase-6 activation and axonal degeneration in vitro
Movement Disorders
Ehrnhoefer, D. E. and Tsang, M. Y. and Qiu, X. and Hayden, M. R.
2014

Personalized gene silencing therapeutics for Huntington disease
Clinical Genetics
Kay, C. and Skotte, N. H. and Southwell, A. L. and Hayden, M. R.
DOI: 10.1111/cge.12385
2014

Striatal Synaptic Dysfunction and Hippocampal Plasticity Deficits in the Hu97/18 Mouse Model of Huntington Disease
Plos One
Kolodziejczyk, K. and Parsons, M. P. and Southwell, A. L. and Hayden, M. R. and Raymond, L. A.
DOI: 10.1371/journal.pone.0094562
2014

The emerging era of pharmacogenomics: current successes, future potential, and challenges
Clinical Genetics
Lee, J. W. and Aminkeng, F. and Bhavsar, A. P. and Shaw, K. and Carleton, B. C. and Hayden, M. R. and Ross, C. J. D.
DOI: 10.1111/cge.12392
2014

Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families
Clinical Genetics
Bochem, A. E. and van Capelleveen, J. C. and Dallinga-Thie, G. M. and Schimmel, A. W. M. and Motazacker, M. M. and Tietjen, I. and Singaraja, R. R. and Hayden, M. R. and Kastelein, J. J. P. and Stroes, E. and Hovingh, G. K.
DOI: 10.1111/cge.12201
2014

VKORC1 and CYP2C9 Genotypes are Predictors of Warfarin-Related Outcomes in Children
Pediatric Blood & Cancer
Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S. R. and Hosking, M. and Neville, K. and Leeder, J. S. and Hayden, M. R. and Ross, C. J. and Carleton, B. C.
DOI: 10.1002/pbc.24932
2014

A novel inhibitor of Caspase-6 provides protection against mutant huntingtin toxicity
Journal of Molecular Neuroscience
Aharony, I. and Ehrnhoefer, D. and Shruster, A. and Franciosi, S. and Hayden, M. R. and Offen, D.
2014

Response to "Evaluation of Pharmacogenetic Markers to Predict the Risk of Cisplatin-Induced Ototoxicity"
Clinical Pharmacology & Therapeutics
Carleton, B. C. and Ross, C. J. and Bhavsar, A. P. and Lee, J. W. and Visscher, H. and Rassekh, S. R. and Hayden, M. R.
DOI: 10.1038/clpt.2014.90
2014

Comparing the Biological Impact of Glatiramer Acetate with the Biological Impact of a Generic
Plos One
Towfic, F. and Funt, J. M. and Fowler, K. D. and Bakshi, S. and Blaugrund, E. and Artyomov, M. N. and Hayden, M. R. and Ladkani, D. and Schwartz, R. and Zeskind, B.
DOI: 10.1371/journal.pone.0083757
2014

A Systematic Review and Meta-Analysis of Clinical Variables Used in Huntington Disease Research
Movement Disorders
Franciosi, S. and Shim, Y. and Lau, M. and Hayden, M. R. and Leavitt, B. R.
DOI: 10.1002/mds.25663
2013

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset
Neurogenetics
Ramos, E. M. and Latourelle, J. C. and Gillis, T. and Mysore, J. S. and Squitieri, F. and Di Pardo, A. and Di Donato, S. and Gellera, C. and Hayden, M. R. and Morrison, P. J. and Nance, M. and Ross, C. A. and Margolis, R. L. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R. J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M. H. and Hersch, S. M. and Rosas, H. D. and Lucente, D. and Harrison, M. B. and Zanko, A. and Abramson, R. K. and Marder, K. and Gusella, J. F. and Lee, J. M. and Alonso, I. and Sequeiros, J. and Myers, R. H. and MacDonald, M. E.
DOI: 10.1007/s10048-013-0364-y
2013

DE NOVO HUNTINGTON DISEASE CAUSED BY 26-44 CAG REPEAT EXPANSION ON A LOW-RISK HAPLOTYPE
Neurology
Houge, G. and Bruland, O. and Bjornevoll, I. and Hayden, M. R. and Semaka, A.
2013

High Frequency of Intermediate Alleles on Huntington Disease-Associated Haplotypes in British Columbia's General Population
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Semaka, A. and Kay, C. and Doty, C. N. and Collins, J. A. and Tam, N. and Hayden, M. R.
DOI: 10.1002/ajmg.b.32193
2013

Memory and synaptic deficits in Hip14/DHHC17 knockout mice
Proceedings of the National Academy of Sciences of the United States of America
Milnerwood, A. J. and Parsons, M. P. and Young, F. B. and Singaraja, R. R. and Franciosi, S. and Volta, M. and Bergeron, S. and Hayden, M. R. and Raymond, L. A.
DOI: 10.1073/pnas.1222384110
2013

Mutations In ABCA8 Result In HDL Deficiency And Cholesterol Efflux Defects
Circulation Research
Singaraja, R. and van Capelleveen, J. and Hovingh, K. and Zhang, L. H. and Dallinga-Thie, G. and Tietjen, I. and Wong, K. and Kastelein, J. J. and Hayden, M. R.
2013

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Nucleic Acids Research
Ostergaard, M. E. and Southwell, A. L. and Kordasiewicz, H. and Watt, A. T. and Skotte, N. H. and Doty, C. N. and Vaid, K. and Villanueva, E. B. and Swayze, E. E. and Bennett, C. F. and Hayden, M. R. and Seth, P. P.
DOI: 10.1093/nar/gkt725
2013

Regulation of ABCA1 Protein Expression and Function in Hepatic and Pancreatic Islet Cells by miR-145
Arteriosclerosis Thrombosis and Vascular Biology
Kang, M. H. and Zhang, L. H. and Wijesekara, N. and de Haan, W. and Butland, S. and Bhattacharjee, A. and Hayden, M. R.
DOI: 10.1161/atvbaha.113.302004
2013

Tracking Brain Palmitoylation Change: Predominance of Glial Change in a Mouse Model of Huntington's Disease
Chemistry & Biology
Wan, J. M. and Savas, J. N. and Roth, A. F. and Sanders, S. S. and Singaraja, R. R. and Hayden, M. R. and Yates, J. R. and Davis, N. G.
DOI: 10.1016/j.chembiol.2013.09.018
2013

"Grasping the Grey": Patient Understanding and Interpretation of an Intermediate Allele Predictive Test Result for Huntington Disease
Journal of Genetic Counseling
Semaka, A. and Balneaves, L. G. and Hayden, M. R.
DOI: 10.1007/s10897-012-9533-7
2013

A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk
Plos One
Kelly, L. E. and Chaudhry, S. A. and Rieder, M. J. and t Jong, G. and Moretti, M. E. and Lausman, A. and Ross, C. and Berger, H. and Carleton, B. and Hayden, M. R. and Madadi, P. and Koren, G.
DOI: 10.1371/journal.pone.0070073
2013

A fully humanized transgenic mouse model of Huntington disease
Human Molecular Genetics
Southwell, A. L. and Warby, S. C. and Carroll, J. B. and Doty, C. N. and Skotte, N. H. and Zhang, W. N. and Villanueva, E. B. and Kovalik, V. and Xie, Y. Y. and Pouladi, M. A. and Collins, J. A. and Yang, X. W. and Franciosi, S. and Hayden, M. R.
DOI: 10.1093/hmg/dds397
2013

ABCA1 influences neuroinflammation and neuronal death
Neurobiology of Disease
Karasinska, J. M. and de Haan, W. and Franciosi, S. and Ruddle, P. and Fan, J. J. and Kruit, J. K. and Stukas, S. and Lutjohann, D. and Gutmann, D. H. and Wellington, C. L. and Hayden, M. R.
DOI: 10.1016/j.nbd.2013.01.018
2013

An Education Based Intervention Study for Reducing CNS Depression among Neonates Exposed to Codeine through Breast Milk
Birth Defects Research Part a-Clinical and Molecular Teratology
Chaudhry, S. and Kelly, L. E. and Rieder, M. and T'Jong, G. and Morretti, M. and Lausman, A. and Ross, C. and Berger, H. and Carleton, B. and Hayden, M. R. and Madadi, P. and Koren, G.
2013

An investigation of morphine-to-codeine metabolic ratios in postmortem blood, drug interactions, and cytochrome P450 2D6 (CYP2D6) genotype
Faseb Journal
Lam, J. and Woodall, K. and Solbeck, P. and Ross, C. J. D. and Carleton, B. and Hayden, M. R. and Koren, G. and Madadi, P.
2013

CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease
Journal of Medical Genetics
Semaka, A. and Kay, C. and Doty, C. and Collins, J. A. and Bijlsma, E. K. and Richards, F. and Goldberg, Y. P. and Hayden, M. R.
DOI: 10.1136/jmedgenet-2013-101796
2013

Cancer Pharmacogenomics in Children: Research Initiatives and Progress to Date
Pediatric Drugs
Rassekh, S. R. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R.
DOI: 10.1007/s40272-013-0021-9
2013

Causes of Variability in Deterioration of Renal Function Among Pediatric Liver Transplant Recipients Receiving Tacrolimus
Therapeutic Drug Monitoring
Gijsen, Vmgj and Hesselink, D. A. and t Jong, G. W. and van Schaik, R. H. N. and Ng, V. and Grant, D. and FerozZada, Y. and Nasserinejad, K. and van Rosmalen, J. and Verjee, Z. and Ross, C. and Carleton, B. and Hayden, M. R. and Tibboel, D. and Dube, M. P. and Koren, G. and de Wildt, S. N.
2013

Choosing an animal model for the study of Huntington's disease
Nature Reviews Neuroscience
Pouladi, M. A. and Morton, A. J. and Hayden, M. R.
DOI: 10.1038/nrn3570
2013

Developing a comprehensive, effective patient-friendly website to enhance decision making in predictive testing for Huntington disease
Genetics in Medicine
Virani, A. K. H. and Creighton, S. M. and Hayden, M. R.
DOI: 10.1038/gim.2012.149
2013

From Mutation Identification to Therapy: Discovery and Origins of the First Approved Gene Therapy in the Western World
Human Gene Therapy
Kastelein, J. J. P. and Ross, C. J. D. and Hayden, M. R.
DOI: 10.1089/hum.2013.063
2013

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy (vol 41, pg 1345, 2009)
Nature Genetics
Ross, C. J. D. and Katzov-Eckert, H. and Dube, M. P. and Brooks, B. and Rassekh, S. R. and Barhdadi, A. and Feroz-Zada, Y. and Visscher, H. and Brown, A. M. K. and Rieder, M. J. and Rogers, P. C. and Phillips, M. S. and Carleton, B. C. and Hayden, M. R. and Cpnds Consortium
DOI: 10.1038/ng.0513-578
2013

Genetic Variation Does Not Influence Renal Function Following Pediatric Kidney Transplantation Receiving Tacrolimus
Therapeutic Drug Monitoring
Gijsen, Vmgj and Hesselink, D. A. and Ross, C. and Dube, M. P. and van Schaik, R. H. N. and Van Gelder, T. and Cransberg, K. and t Jong, G. W. and Feroz-Zada, Y. and Nasserinejad, K. and van Rosmalen, J. and Hebert, D. and Grant, D. and Verjee, Z. and Carlton, B. and Hayden, M. R. and Tibboel, D. and de Wildt, S. N. and Koren, G.
2013

Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease
Human Molecular Genetics
Sutton, L. M. and Sanders, S. S. and Butland, S. L. and Singaraja, R. R. and Franciosi, S. and Southwell, A. L. and Doty, C. N. and Schmidt, M. E. and Mui, K. K. N. and Kovalik, V. and Young, F. B. and Zhang, W. N. and Hayden, M. R.
DOI: 10.1093/hmg/dds441
2013

HLA-A*31:01 and HLA-B*15:02 as Genetic Markers for Carbamazepine Hypersensitivity in Children
Clinical Pharmacology & Therapeutics
Amstutz, U. and Ross, C. J. D. and Castro-Pastrana, L. I. and Rieder, M. J. and Shear, N. H. and Hayden, M. R. and Carleton, B. C. and Cpnds Consortium
DOI: 10.1038/clpt.2013.55
2013

Hunting human disease genes: lessons from the past, challenges for the future
Human Genetics
Brunham, L. R. and Hayden, M. R.
DOI: 10.1007/s00439-013-1286-3
2013

Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes
European Journal of Human Genetics
Baine, F. K. and Kay, C. and Ketelaar, M. E. and Collins, J. A. and Semaka, A. and Doty, C. N. and Krause, A. and Greenberg, L. J. and Hayden, M. R.
DOI: 10.1038/ejhg.2013.2
2013

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6
Cell Death and Differentiation
van Raam, B. J. and Ehrnhoefer, D. E. and Hayden, M. R. and Salvesen, G. S.
DOI: 10.1038/cdd.2012.98
2013

Investigating Genetic and Clinical Sources of Variability in Predicting Deterioration of Renal Function Among Pediatric Heart Transplant Recipients Receiving Tacrolimus
Therapeutic Drug Monitoring
Gijsen, Vmgj and Dube, M. P. and Hesselink, D. A. and Ross, C. and Mital, S. and t Jong, G. W. and van Schaik, R. H. N. and Dalinghaus, M. and Grant, D. and Zada, Y. F. and Nasserinejad, K. and van Rosmalen, J. and Verjee, Z. and Carleton, B. and Hayden, M. R. and Tibboel, D. and Koren, G. and de Wildt, S. N.
2013

Life-threatening adverse events following therapeutic opioid administration in adults: Is pharmacogenetic analysis useful?
Pain Research & Management
Madadi, P. and Sistonen, J. and Silverman, G. and Gladdy, R. and Ross, C. J. and Carleton, B. C. and Carvalho, J. C. and Hayden, M. R. and Koren, G.
2013

Pharmacogenetics of warfarin safety and effectiveness in children
Faseb Journal
Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S. R. and Dube, M. P. and Hayden, M. R. and Ross, C. J. and Carleton, B. C.
2013

Pharmacogenomics of vincristine-induced neurotoxicity in pediatric cancer patients
Faseb Journal
Amstutz, U. and Loo, T. T. and Gylling, H. M. and Rassekh, R. and Hukin, J. and Zada, Y. F. and Dube, M. P. and Brown, A. M. and Phillips, M. S. and Hayden, M. R. and Ross, C. J. and Carleton, B. C.
2013

Predicting Anthracycline-induced Cardiotoxicity in Children - Genome-Wide Association Study
Faseb Journal
Aminkeng, F. and Ross, C. J. D. and Rassekh, R. S. and Brunham, L. R. and Weissman, C. and Dube, M. P. and Visscher, H. and Rieder, M. J. and Carleton, B. C. and Hayden, M. R.
2013

Providing predictive testing for Huntington disease via telehealth: results of a pilot study in British Columbia, Canada
Clinical Genetics
Hawkins, A. K. and Creighton, S. and Ho, A. and McManus, B. and Hayden, M. R.
DOI: 10.1111/cge.12033
2013

Putative Association of ABCB1 2677G > T/A With Oxycodone-Induced Central Nervous System Depression in Breastfeeding Mothers
Therapeutic Drug Monitoring
Lam, J. and Kelly, L. and Matok, I. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R. and Madadi, P. and Koren, G.
DOI: 10.1097/FTD.0b013e318288f158
2013

Replication of TPMT and ABCC3 Genetic Variants Highly Associated With Cisplatin-Induced Hearing Loss in Children
Clinical Pharmacology & Therapeutics
Pussegoda, K. and Ross, C. J. and Visscher, H. and Yazdanpanah, M. and Brooks, B. and Rassekh, S. R. and Zada, Y. F. and Dube, M. P. and Carleton, B. C. and Hayden, M. R. and Cpnds Consortium
DOI: 10.1038/clpt.2013.80
2013

Sirtuin modulators alter mitochondrial function in in vitro and in vivo Huntington's disease models
European Journal of Clinical Investigation
Naia, L. and Rosenstock, T. R. and Oliveira-Sousa, S. I. and Caldeira, G. L. and Laco, M. N. and Hayden, M. R. and Rego, A. C.
2013

Special new feature in Clinical Genetics
Clinical Genetics
Hayden, M. R.
DOI: 10.1111/cge.12067
2013

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models
Nature Medicine
Marco, S. and Giralt, A. and Petrovic, M. M. and Pouladi, M. A. and Martinez-Turrillas, R. and Martinez-Hernndez, J. and Kaltenbach, L. S. and Torres-Peraza, J. and Graham, R. K. and Watanabe, M. and Lujan, R. and Nakanishi, N. and Lipton, S. A. and Lo, D. C. and Hayden, M. R. and Alberch, J. and Wesseling, J. F. and Perez-Otano, I.
DOI: 10.1038/nm.3246
2013

The Impact of Partial and Complete Loss-of-Function Mutations in Endothelial Lipase on High-Density Lipoprotein Levels and Functionality in Humans
Circulation-Cardiovascular Genetics
Singaraja, R. R. and Sivapalaratnam, S. and Hovingh, K. and Dube, M. P. and Castro-Perez, J. and Collins, H. L. and Adelman, S. J. and Riwanto, M. and Manz, J. and Hubbard, B. and Tietjen, I. and Wong, K. and Mitnaul, L. J. and van Heek, M. and Lin, L. and Roddy, T. A. and McEwen, J. and Dallinge-Thie, G. and van Vark-van der Zee, L. and Verwoert, G. and Winther, M. and van Duijn, C. and Hofman, A. and Trip, M. D. and Marais, A. D. and Asztalos, B. and Landmesser, U. and Sijbrands, E. and Kastelein, J. J. and Hayden, M. R.
DOI: 10.1161/circgenetics.111.962613
2013

The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-chaperone Activity of SGT1 to Subvert Immunity
Plos Pathogens
Bhavsar, A. P. and Brown, N. F. and Stoepel, J. and Wiermer, M. and Martin, D. D. O. and Hsu, K. J. and Imami, K. and Ross, C. J. and Hayden, M. R. and Foster, L. J. and Li, X. and Hieter, P. and Finlay, B. B.
DOI: 10.1371/journal.ppat.1003518
2013

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children
Pediatric Blood & Cancer
Visscher, H. and Ross, C. J. D. and Rassekh, S. R. and Sandor, G. S. S. and Caron, H. N. and van Dalen, E. C. and Kremer, L. C. and van der Pal, H. J. and Rogers, P. C. and Rieder, M. J. and Carleton, B. C. and Hayden, M. R. and Cpnds Consortium
DOI: 10.1002/pbc.24505
2013

When access is an issue: exploring barriers to predictive testing for Huntington disease in British Columbia, Canada
European Journal of Human Genetics
Hawkins, A. K. and Creighton, S. and Hayden, M. R.
DOI: 10.1038/ejhg.2012.147
2013

Peripheral and cerebral metabolic features in an animal model of Huntington's disease
2012 Ieee 2nd Portuguese Meeting in Bioengineering
Lopes, C. and Duarte, A. I. and Hayden, M. and Rego, A. C. and Ieee,
2012

Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol
Plos One
Tietjen, I. and Hovingh, G. K. and Singaraja, R. R. and Radomski, C. and Barhdadi, A. and McEwen, J. and Chan, E. and Mattice, M. and Legendre, A. and Franchini, P. L. and Dube, M. P. and Kastelein, J. J. P. and Hayden, M. R.
DOI: 10.1371/journal.pone.0037437
2012

Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin
Journal of Neuroscience
Waldron-Roby, E. and Ratovitski, T. and Wang, X. F. and Jiang, M. L. and Watkin, E. and Arbez, N. and Graham, R. K. and Hayden, M. R. and Hou, Z. P. and Mori, S. and Swing, D. and Pletnikov, M. and Duan, W. Z. and Tessarollo, L. and Ross, C. A.
DOI: 10.1523/jneurosci.1305-11.2012
2012

Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
Pain
Goldberg, Y. P. and Price, N. and Namdari, R. and Cohen, C. J. and Lamers, M. H. and Winters, C. and Price, J. and Young, C. E. and Verschoof, H. and Sherrington, R. and Pimstone, S. N. and Hayden, M. R.
DOI: 10.1016/j.pain.2011.09.008
2012

What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration
Clinical Genetics
Ketelaar, M. E. and Hofstra, R. M. W. and Hayden, M. R.
DOI: 10.1111/j.1399-0004.2011.01795.x
2012

Whole-Genome Sequencing: The New Standard of Care?
Science
Brunham, L. R. and Hayden, M. R.
DOI: 10.1126/science.1220967
2012

Adoption and the communication of genetic risk: experiences in Huntington disease
Clinical Genetics
Bombard, Y. and Semaka, A. and Hayden, M. R.
DOI: 10.1111/j.1399-0004.2010.01614.x
2012

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease
Neurobiology of Disease
Franciosi, S. and Ryu, J. K. and Shim, Y. and Hill, A. and Connolly, C. and Hayden, M. R. and McLarnon, J. G. and Leavitt, B. R.
DOI: 10.1016/j.nbd.2011.09.003
2012

Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases
Trends in Molecular Medicine
Southwell, A. L. and Skotte, N. H. and Bennett, C. F. and Hayden, M. R.
DOI: 10.1016/j.molmed.2012.09.001
2012

Apnea and Oxygen Desaturations in Children Treated with Opioids after Adenotonsillectomy for Obstructive Sleep Apnea Syndrome A Prospective Pilot Study
Pediatric Drugs
Khetani, J. D. and Madadi, P. and Sommer, D. D. and Reddy, D. and Sistonen, J. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R. and Koren, G.
2012

Beyond the patient: The broader impact of genetic discrimination among individuals at risk of Huntington disease
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Bombard, Y. and Palin, J. and Friedman, J. M. and Veenstra, G. and Creighton, S. and Bottorff, J. L. and Hayden, M. R. and Canadian Respond, H. D. Collaborative
DOI: 10.1002/ajmg.b.32016
2012

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
Neurology
Lee, J. M. and Ramos, E. M. and Lee, J. H. and Gillis, T. and Mysore, J. S. and Hayden, M. R. and Warby, S. C. and Morrison, P. and Nance, M. and Ross, C. A. and Margolis, R. L. and Squitieri, F. and Orobello, S. and Di Donato, S. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R. J. A. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M. H. and Hersch, S. M. and Rosas, H. D. and Lucente, D. and Harrison, M. B. and Zanko, A. and Abramson, R. K. and Marder, K. and Sequeiros, J. and Paulsen, J. S. and Landwehrmeyer, G. B. and Myers, R. H. and MacDonald, M. E. and Gusella, J. F. and Predict-Hd Study Huntington and Registry Study European and Hd-Maps Study Grp and Cohort Study HSG
DOI: 10.1212/WNL.0b013e318249f683
2012

Central Nervous System Depression of Neonates Breastfed by Mothers Receiving Oxycodone for Postpartum Analgesia
Journal of Pediatrics
Lam, J. and Kelly, L. and Ciszkowski, C. and Landsmeer, M. L. A. and Nauta, M. and Carleton, B. C. and Hayden, M. R. and Madadi, P. and Koren, G.
DOI: 10.1016/j.jpeds.2011.06.050
2012

Common SNP-Based Haplotype Analysis of the 4p16.3 Huntington Disease Gene Region
American Journal of Human Genetics
Lee, J. M. and Gillis, T. and Mysore, J. S. and Ramos, E. M. and Myers, R. H. and Hayden, M. R. and Morrison, P. J. and Nance, M. and Ross, C. A. and Margolis, R. L. and Squitieri, F. and Griguoli, A. and Di Donato, S. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R. J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M. H. and Hersch, S. M. and Rosas, H. D. and Lucente, D. and Harrison, M. B. and Zanko, A. and Abramson, R. K. and Marder, K. and Sequeiros, J. and MacDonald, M. E. and Gusella, J. F.
DOI: 10.1016/j.ajhg.2012.01.005
2012

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin
Pharmacogenomics Journal
Brunham, L. R. and Lansberg, P. J. and Zhang, L. and Miao, F. and Carter, C. and Hovingh, G. K. and Visscher, H. and Jukema, J. W. and Stalenhoef, A. F. and Ross, C. J. D. and Carleton, B. C. and Kastelein, J. J. P. and Hayden, M. R.
DOI: 10.1038/tpj.2010.92
2012

Economic impact of a genetic test for cisplatin-induced ototoxicity
Pharmacogenomics Journal
Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.
DOI: 10.1038/tpj.2011.15
2012

Economic impact of a genetic test for cisplatin-induced ototoxicity (vol 12, pg 205, 2011)
Pharmacogenomics Journal
Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.
DOI: 10.1038/tpj.2011.21
2012

Human Mendelian pain disorders: a key to discovery and validation of novel analgesics
Clinical Genetics
Goldberg, Y. P. and Pimstone, S. N. and Namdari, R. and Price, N. and Cohen, C. and Sherrington, R. P. and Hayden, M. R.
DOI: 10.1111/j.1399-0004.2012.01942.x
2012

Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
Tietjen, I. and Hovingh, G. K. and Singaraja, R. and Radomski, C. and McEwen, J. and Chan, E. and Mattice, M. and Legendre, A. and Kastelein, J. J. P. and Hayden, M. R.
DOI: 10.1016/j.bbalip.2011.08.006
2012

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired beta-Cell Function
Diabetes
Kruit, J. K. and Wijesekara, N. and Westwell-Roper, C. and Vanmierlo, T. and de Haan, W. and Bhattacharjee, A. and Tang, R. M. and Wellington, C. L. and LutJohann, D. and Johnson, J. D. and Brunham, L. R. and Verchere, C. B. and Hayden, M. R.
DOI: 10.2337/db11-1341
2012

Low Levels of Human HIP14 Are Sufficient to Rescue Neuropathological, Behavioural, and Enzymatic Defects Due to Loss of Murine HIP14 in Hip14-/- Mice
Plos One
Young, F. B. and Franciosi, S. and Spreeuw, A. and Deng, Y. and Sanders, S. and Tam, N. C. M. and Huang, K. and Singaraja, R. R. and Zhang, W. N. and Bissada, N. and Kay, C. and Hayden, M. R.
DOI: 10.1371/journal.pone.0036315
2012

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice
Human Molecular Genetics
Pouladi, M. A. and Stanek, L. M. and Xie, Y. Y. and Franciosi, S. and Southwell, A. L. and Deng, Y. and Butland, S. and Zhang, W. N. and Cheng, S. H. and Shihabuddin, L. S. and Hayden, M. R.
DOI: 10.1093/hmg/dds037
2012

miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets
Diabetes
Wijesekara, N. and Zhang, L. H. and Kang, M. H. and Abraham, T. and Bhattacharjee, A. and Warnock, G. L. and Verchere, C. B. and Hayden, M. R.
DOI: 10.2337/db11-0944
2012

More Codeine Fatalities After Tonsillectomy in North American Children
Pediatrics
Kelly, L. E. and Rieder, M. and van den Anker, J. and Malkin, B. and Ross, C. and Neely, M. N. and Carleton, B. and Hayden, M. R. and Madadi, P. and Koren, G.
DOI: 10.1542/peds.2011-2538
2012

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
Neurobiology of Disease
Pouladi, M. A. and Brillaud, E. and Xie, Y. Y. and Conforti, P. and Graham, R. K. and Ehrnhoefer, D. E. and Franciosi, S. and Zhang, W. N. and Poucheret, P. and Compte, E. and Maurel, J. C. and Zuccato, C. and Cattaneo, E. and Neri, C. and Hayden, M. R.
DOI: 10.1016/j.nbd.2012.06.026
2012

Personalized Medicine: Temper Expectations Response
Science
Brunham, L. R. and Hayden, M. R.
2012

PHARMACOGENETIC INSIGHT INTO OXYCODONE: IMPLICATIONS TO BREASTFEEDING MOTHERS AND NEONATES DURING THE POSTPARTUM PERIOD
Clinical Pharmacology & Therapeutics
Lam, J. and Madadi, P. and Matok, I. and Kelly, L. and Carleton, B. C. and Hayden, M. R. and Koren, G.
2012

Pharmacogenetics of Warfarin in Children
Pharmacoepidemiology and Drug Safety
Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S. R. and Ross, C. J. and Hayden, M. R. and Carleton, B. C.
2012

Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children
Journal of Clinical Oncology
Visscher, H. and Ross, C. J. D. and Rassekh, S. R. and Barhdadi, A. and Dube, M. P. and Al-Saloos, H. and Sandor, G. S. and Caron, H. N. and van Dalen, E. C. and Kremer, L. C. and van der Pal, H. J. and Brown, A. M. K. and Rogers, P. C. and Phillips, M. S. and Rieder, M. J. and Carleton, B. C. and Hayden, M. R. and Canadian Pharmacogenomics, Network
DOI: 10.1200/jco.2010.34.3467
2012

Polyglutamine diseases and the risk of cancer
Lancet Oncology
Pouladi, M. A. and Hayden, M. R.
2012

Population stratification may bias analysis of PGC-1 alpha as a modifier of age at Huntington disease motor onset
Human Genetics
Ramos, E. M. and Latourelle, J. C. and Lee, J. H. and Gillis, T. and Mysore, J. S. and Squitieri, F. and Di Pardo, A. and Di Donato, S. and Hayden, M. R. and Morrison, P. J. and Nance, M. and Ross, C. A. and Margolis, R. L. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R. J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M. H. and Hersch, S. M. and Rosas, H. D. and Lucente, D. and Harrison, M. B. and Zanko, A. and Marder, K. and Gusella, J. F. and Lee, J. M. and Alonso, I. and Sequeiros, J. and Myers, R. H. and MacDonald, M. E.
DOI: 10.1007/s00439-012-1205-z
2012

Postpartum Maternal Codeine Therapy and the Risk of Adverse Neonatal Outcomes: The Devil is in the Details
Therapeutic Drug Monitoring
Lam, J. and Matlow, J. N. and Ross, C. J. D. and Hayden, M. R. and Carleton, B. C. and Madadi, P.
DOI: 10.1097/FTD.0b013e31825da19f
2012

Prediction of Codeine Toxicity in Infants and Their Mothers Using a Novel Combination of Maternal Genetic Markers
Clinical Pharmacology & Therapeutics
Sistonen, J. and Madadi, P. and Ross, C. J. and Yazdanpanah, M. and Lee, J. W. and Landsmeer, M. L. A. and Nauta, M. and Carleton, B. C. and Koren, G. and Hayden, M. R.
DOI: 10.1038/clpt.2011.280
2012

Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases
Progress in Neurobiology
Young, F. B. and Butland, S. L. and Sanders, S. S. and Sutton, L. M. and Hayden, M. R.
DOI: 10.1016/j.pneurobio.2011.11.002
2012

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
Human Molecular Genetics
Uribe, V. and Wong, B. K. Y. and Graham, R. K. and Cusack, C. L. and Skotte, N. H. and Pouladi, M. A. and Xie, Y. Y. and Feinberg, K. and Ou, Y. M. and Ouyang, Y. B. and Deng, Y. and Franciosi, S. and Bissada, N. and Spreeuw, A. and Zhang, W. N. and Ehrnhoefer, D. E. and Vaid, K. and Miller, F. D. and Deshmukh, M. and Howland, D. and Hayden, M. R.
DOI: 10.1093/hmg/dds005
2012

TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease
Biochemical and Biophysical Research Communications
Lee, J. H. and Lee, J. M. and Ramos, E. M. and Gillis, T. and Mysore, J. S. and Kishikawa, S. and Hadzi, T. and Hendricks, A. E. and Hayden, M. R. and Morrison, P. J. and Nance, M. and Ross, C. A. and Margolis, R. L. and Squitieri, F. and Gellera, C. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R. J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M. H. and Hersch, S. M. and Rosas, H. D. and Lucente, D. and Harrison, M. B. and Zanko, A. and Abramson, R. K. and Marder, K. and Sequeiros, J. and Landwehrmeyer, G. B. and Shoulson, I. and Richard, R. H. and Marcy, M. E. and James, J. F. and Registry Study European, Huntington and Huntington Study Grp, COHORt Projec
DOI: 10.1016/j.bbrc.2012.06.120
2012

An Interaction of Genes in Our Social Environment: Genetic Discrimination among Persons at Risk for Huntington Disease
Challenging Genetic Determinism: New Perspectives on the Gene in Its Multiple Environments
Bombard, Y. and Hayden, M. R.
2011

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14
Human Molecular Genetics
Huang, K. and Sanders, S. S. and Kang, R. J. and Carroll, J. B. and Sutton, L. and Wan, J. M. and Singaraja, R. and Young, F. B. and Liu, L. L. and El-Husseini, A. and Davis, N. G. and Hayden, M. R.
DOI: 10.1093/hmg/ddr242
2011

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture
Plos One
Ehrnhoefer, D. E. and Skotte, N. H. and Savill, J. and Nguyen, Y. T. N. and Ladha, S. and Cao, L. P. and Dullaghan, E. and Hayden, M. R.
DOI: e27680 10.1371/journal.pone.0027680
2011

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease
Neurobiology of Disease
Simpson, Jessica M. and Gil-Mohapel, Joana and Pouladi, Mahmoud A. and Ghilan, Mohamed and Xie, Yuanyun and Hayden, Michael R. and Christie, Brian R.
DOI: 10.1016/j.nbd.2010.09.012
2011

Altered palmitoylation and neuropathological deficits in mice lacking HIP14
Human Molecular Genetics
Singaraja, R. R. and Huang, K. and Sanders, S. S. and Milnerwood, A. J. and Hines, R. and Lerch, J. P. and Franciosi, S. and Drisdel, R. C. and Vaid, K. and Young, F. B. and Doty, C. and Wan, J. M. and Bissada, N. and Henkelman, R. M. and Green, W. N. and Davis, N. G. and Raymond, L. A. and Hayden, M. R.
DOI: 10.1093/hmg/ddr308
2011

Amelioration of Hypertriglyceridemia with Hypo-Alpha-Cholesterolemia in LPL Deficient Mice by Hematopoietic Cell-Derived LPL
Plos One
Ding, Y. Y. and Zhang, L. and Wang, Y. H. and Huang, W. and Tang, Y. and Bai, L. and Ross, C. J. D. and Hayden, M. R. and Liu, G.
DOI: e25620 10.1371/journal.pone.0025620
2011

Caspase-6 and neurodegeneration
Trends in Neurosciences
Graham, R. K. and Ehrnhoefer, D. E. and Hayden, M. R.
DOI: 10.1016/j.tins.2011.09.001
2011

Cholesterol metabolism in Huntington disease
Nature Reviews Neurology
Karasinska, J. M. and Hayden, M. R.
DOI: 10.1038/nrneurol.2011.132
2011

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development
Nature Reviews Drug Discovery
Ehrnhoefer, D. E. and Wong, B. K. Y. and Hayden, M. R.
DOI: 10.1038/nrd3556
2011

CYP2D6 Polymorphisms and Codeine Analgesia in Postpartum Pain Management: A Pilot Study
Therapeutic Drug Monitoring
vanderVaart, S. and Berger, H. and Sistonen, J. and Madadi, P. and Matok, I. and Gijsen, Vmgj and de Wildt, S. N. and Taddio, A. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R. and Koren, G.
DOI: 10.1097/FTD.0b013e3182272b10
2011

Diagnostic Testing for Vaccinomics: Is the Regulatory Approval Framework Adequate? A Comparison of Canada, the United States, and Europe
Omics-a Journal of Integrative Biology
Joly, Y. and Koutrikas, G. and Ramos-Paque, E. and Zawati, M. and Gardy, J. and Hayden, M. R. and Carleton, B. C.
DOI: 10.1089/omi.2010.0135
2011

Factors Associated With Experiences of Genetic Discrimination Among Individuals at Risk for Huntington Disease
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Bombard, Yvonne and Palin, JoAnne and Friedman, Jan M. and Veenstra, Gerry and Creighton, Susan and Paulsen, Jane S. and Bottorff, Joan L. and Hayden, Michael R. and Canadian Respond-HD Collaborative
DOI: 10.1002/ajmg.b.31130
2011

HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia
European Journal of Human Genetics
Warby, S. C. and Visscher, H. and Collins, J. A. and Doty, C. N. and Carter, C. and Butland, S. L. and Hayden, A. R. and Kanazawa, I. and Ross, C. J. and Hayden, M. R.
DOI: 10.1038/ejhg.2010.229
2011

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
Diabetes
Kruit, J. K. and Wijesekara, N. and Fox, J. E. M. and Dai, X. Q. and Brunham, L. R. and Searle, G. J. and Morgan, G. P. and Costin, A. J. and Tang, R. M. and Bhattacharjee, A. and Johnson, J. D. and Light, P. E. and Marsh, B. J. and MacDonald, P. E. and Verchere, C. B. and Hayden, M. R.
DOI: 10.2337/db11-0081
2011

Lessons from predictive testing for Huntington disease: 25 years on
Journal of Medical Genetics
Hawkins, A. K. and Ho, A. and Hayden, M. R.
DOI: 10.1136/jmedgenet-2011-100352
2011

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease
Molecular Neurodegeneration
Carroll, J. B. and Southwell, A. L. and Graham, R. K. and Lerch, J. P. and Ehrnhoefer, D. E. and Cao, L. P. and Zhang, W. N. and Deng, Y. and Bissada, N. and Henkelman, R. M. and Hayden, M. R.
DOI: 59 10.1186/1750-1326-6-59
2011

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Nature Medicine
Song, Wenjun and Chen, Jin and Petrilli, Alejandra and Liot, Geraldine and Klinglmayr, Eva and Zhou, Yue and Poquiz, Patrick and Tjong, Jonathan and Pouladi, Mahmoud A. and Hayden, Michael R. and Masliah, Eliezer and Ellisman, Mark and Rouiller, Isabelle and Schwarzenbacher, Robert and Bossy, Blaise and Perkins, Guy and Bossy-Wetzel, Ella
DOI: 10.1038/nm.2313
2011

Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease
Neurobiology of Disease
Carroll, Jeffrey B. and Lerch, Jason P. and Franciosi, Sonia and Spreeuw, Amanda and Bissada, Nagat and Henkelman, R. Mark and Hayden, Michael R.
DOI: 10.1016/j.nbd.2011.03.018
2011

Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans
Clinical Genetics
Brunham, L. R. and Tietjen, I. and Bochem, A. E. and Singaraja, R. R. and Franchini, P. L. and Radomski, C. and Mattice, M. and Legendre, A. and Hovingh, G. K. and Kastelein, J. J. P. and Hayden, M. R.
DOI: 10.1111/j.1399-0004.2011.01682.x
2011

Pharmacogenomics of Cardiovascular Drugs and Adverse Effects in Pediatrics
Journal of Cardiovascular Pharmacology
Visscher, Henk and Amstutz, Ursula and Sistonen, Johanna and Ross, Colin J. and Hayden, Michael R. and Carleton, Bruce C.
DOI: 10.1097/FJC.0b013e3182163b82
2011

Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene/Allele-Specific Silencing of Mutant Huntingtin
Molecular Therapy
Carroll, J. B. and Warby, S. C. and Southwell, A. L. and Doty, C. N. and Greenlee, S. and Skotte, N. and Hung, G. and Bennett, C. F. and Freier, S. M. and Hayden, M. R.
DOI: 10.1038/mt.2011.201
2011

Regulatory Approval for New Pharmacogenomic Tests: A Comparative Overview
Food and Drug Law Journal
Joly, Y. and Koutrikas, G. and Tasse, A. M. and Issa, A. and Carleton, B. and Hayden, M. and Rieder, M. J. and Ramos-Paque, E. and Avard, D.
2011

Small Changes, Big Impact: Posttranslational Modifications and Function of Huntingtin in Huntington Disease
Neuroscientist
Ehrnhoefer, D. E. and Sutton, L. and Hayden, M. R.
DOI: 10.1177/1073858410390378
2011

The Dynamics of Macrophage Infiltration into the Arterial Wall during Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice
American Journal of Pathology
Ye, D. and Zhao, Y. and Hildebrand, R. B. and Singaraja, R. R. and Hayden, M. R. and Van Berkel, T. J. C. and Van Eck, M.
DOI: 10.1016/j.ajpath.2010.11.007
2011

A grand challenge: Providing benefits of clinical genetics to those in need
Genetics in Medicine
Hawkins, A. K. and Hayden, M. R.
DOI: 10.1097/GIM.0b013e31820c056e
2011

TREATMENT WITH ARIMOCLOMOL DOES NOT LEAD TO RESCUE OF MOTOR OR STRIATAL DEFICITS IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
Journal of Neurology Neurosurgery and Psychiatry
Pouladi, M. A. and Carroll, J. and Santos, R. D. and Bertram, L. and Hayden, M. R.
DOI: 10.1136/jnnp.2010.222596.12
2010

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis
Human Molecular Genetics
Becanovic, Kristina and Pouladi, Mahmoud A. and Lim, Raymond S. and Kuhn, Alexandre and Pavlidis, Paul and Luthi-Carter, Ruth and Hayden, Michael R. and Leavitt, Blair R.
DOI: 10.1093/hmg/ddq018
2010

A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans
Human Molecular Genetics
Acuna-Alonzo, V. and Flores-Dorantes, T. and Kruit, J. K. and Villarreal-Molina, T. and Arellano-Campos, O. and Hunemeier, T. and Moreno-Estrada, A. and Ortiz-Lopez, M. G. and Villamil-Ramirez, H. and Leon-Mimila, P. and Villalobos-Comparan, M. and Jacobo-Albavera, L. and Ramirez-Jimenez, S. and Sikora, M. and Zhang, L. H. and Pape, T. D. and Granados-Silvestre, M. D. and Montufar-Robles, I. and Tito-Alvarez, A. M. and Zurita-Salinas, C. and Bustos-Arriaga, J. and Cedillo-Barron, L. and Gomez-Trejo, C. and Barquera-Lozano, R. and Vieira, J. P. and Granados, J. and Romero-Hidalgo, S. and Huertas-Vazquez, A. and Gonzalez-Martin, A. and Gorostiza, A. and Bonatto, S. L. and Rodriguez-Cruz, M. and Wang, L. and Tusie-Luna, T. and Aguilar-Salinas, C. A. and Lisker, R. and Moises, R. S. and Menjivar, M. and Salzano, F. M. and Knowler, W. C. and Bortolini, M. C. and Hayden, M. R. and Baier, L. J. and Canizales-Quinteros, S.
DOI: 10.1093/hmg/ddq173
2010

Adenosine-Triphosphate-Binding Cassette Transporter-1 Trafficking and Function
Trends in Cardiovascular Medicine
Kang, Martin H. and Singaraja, Roshni and Hayden, Michael R.
2010

Adenosine-triphosphate-binding cassette transporter-1 trafficking and function (vol 20, pg 41, 2010)
Trends in Cardiovascular Medicine
Kang, M. H. and Singaraja, R. and Hayden, M. R.
DOI: 10.1016/j.tcm.2010.09.001
2010

BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice
Journal of Neuroscience
Xie, Y. X. and Hayden, M. R. and Xu, B. J.
DOI: 10.1523/jneurosci.1637-10.2010
2010

CAG-Repeat Length and the Age of Onset in Huntington Disease (HD): A Review and Validation Study of Statistical Approaches
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Langbehn, Douglas R. and Hayden, Michael R. and Paulsen, Jane S. and PREDICT-HD Investigators Huntingto
DOI: 10.1002/ajmg.b.30992
2010

Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic beta-Cell Dysfunction
Diabetes Care
Vergeer, Menno and Brunham, Liam R. and Koetsveld, Joris and Kruit, Janine K. and Verchere, C. Bruce and Kastelein, John J. P. and Hayden, Michael R. and Stroes, Erik S. G.
DOI: 10.2337/dc09-1562
2010

CASPASE 6 RESISTANT MUTANT HUNTINGTIN DOES NOT RESCUE THE TOXIC EFFECTS OF CASPASE CLEAVABLE MUTANT HUNTINGTIN IN VIVO
Journal of Neurology Neurosurgery and Psychiatry
Graham, R. K. and Deng, Y. and Pouladi, M. A. and Vaid, K. and Xie, Y. and Bissada, N. and Franciosi, S. and Hayden, M. R.
DOI: 10.1136/jnnp.2010.222570.4
2010

Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes
Journal of Neuroscience
Valenza, M. and Leoni, V. and Karasinska, J. M. and Petricca, L. and Fan, J. J. and Carroll, J. and Pouladi, M. A. and Fossale, E. and Nguyen, H. P. and Riess, O. and MacDonald, M. and Wellington, C. and DiDonato, S. and Hayden, M. and Cattaneo, E.
DOI: 10.1523/jneurosci.0917-10.2010
2010

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice
Diabetologia
Kruit, J. K. and Kremer, P. H. C. and Dai, L. and Tang, R. and Ruddle, P. and de Haan, W. and Brunham, L. R. and Verchere, C. B. and Hayden, M. R.
DOI: 10.1007/s00125-010-1691-2
2010

Cholesterol in beta-cell Dysfunction: The Emerging Connection Between HDL Cholesterol and Type 2 Diabetes
Current Diabetes Reports
Brunham, Liam R. and Kruit, Janine K. and Hayden, Michael R. and Verchere, C. Bruce
DOI: 10.1007/s11892-009-0090-x
2010

Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice. Reply to: de Souza JC, de Oliveira CAM, Carneiro EM et al. letter
Diabetologia
Kruit, J. K. and Brunham, L. R. and Verchere, C. B. and Hayden, M. R.
DOI: 10.1007/s00125-010-1877-7
2010

Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo
Journal of Neuroscience
Graham, R. K. and Deng, Y. and Carroll, J. and Vaid, K. and Cowan, C. and Pouladi, M. A. and Metzler, M. and Bissada, N. and Wang, L. L. and Faull, R. L. M. and Gray, M. and Yang, X. W. and Raymond, L. A. and Hayden, M. R.
DOI: 10.1523/jneurosci.2071-10.2010
2010

Communicating Pharmacogenetic Research Results to Breastfeeding Mothers Taking Codeine: A Pilot Study of Perceptions and Benefits
Clinical Pharmacology & Therapeutics
Madadi, P. and Joly, Y. and Avard, D. and Chitayat, D. C. and Smith, M. A. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R. and Koren, G.
DOI: 10.1038/clpt.2010.125
2010

CROSS SECTIONAL AND LONGITUDINAL 3T MAGNETIC RESONANCE SPECTROSCOPY IN A TRACK-HD COHORT OF INDIVIDUALS WITH PREMANIFEST AND EARLY HUNTINGTON'S DISEASE
Journal of Neurology Neurosurgery and Psychiatry
Sturrock, A. and Laule, C. and Decolongon, J. and Santos, R. D. and Coleman, A. J. and Creighton, S. and Bechtel, N. and Reilmann, R. and Hayden, M. R. and Tabrizi, S. J. and Mackay, A. L. and Leavitt, B. R.
DOI: 10.1136/jnnp.2010.222653.6
2010

Dynamics of Macrophage Infiltration into the Arterial Wall at Different Stages of Atherosclerotic Lesion Development and Dependency on Macrophage ABCA1 Expression
Circulation
Ye, D. and Hildebrand, R. B. and Singaraja, R. R. and Hayden, M. R. and van Berkel, T. J. and Van Eck, M.
2010

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice
Neuron
Milnerwood, Austen J. and Gladding, Clare M. and Pouladi, Mahmoud A. and Kaufman, Alexandra M. and Hines, Rochelle M. and Boyd, Jamie D. and Ko, Rebecca W. Y. and Vasuta, Oana C. and Graham, Rona K. and Hayden, Michael R. and Murphy, Timothy H. and Raymond, Lynn A.
DOI: 10.1016/j.neuron.2010.01.008
2010

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice (vol 65, pg 178, 2010)
Neuron
Milnerwood, Austen J. and Gladding, Clare M. and Pouladi, Mahmoud A. and Kaufman, Alexandra M. and Hines, Rochelle M. and Boyd, Jamie D. and Ko, Rebecca W. Y. and Vasuta, Oana C. and Graham, Rona K. and Hayden, Michael R. and Murphy, Timothy H. and Raymond, Lynn A.
DOI: 10.1016/j.neuron.2010.01.031
2010

Effects of Endothelial Lipase Loss-of-Function Mutations on HDLc Levels in the General Population
Arteriosclerosis Thrombosis and Vascular Biology
Tietjen, Ian and Singaraja, Roshni and Hovingh, G. Kees and Motazacker, M. Madhi and Kuivenhoven, Jan Albert and Kastelein, John J. and Hayden, Michael R.
2010

Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions
Pediatrics
Madadi, Parvaz and Hildebrandt, Doris and Gong, Inna Y. and Schwarz, Ute I. and Ciszkowski, Catherine and Ross, Colin J. D. and Sistonen, Johanna and Carleton, Bruce C. and Hayden, Michael R. and Lauwers, Albert E. and Koren, Gideon
DOI: 10.1542/peds.2009-1907
2010

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
Human Molecular Genetics
Pouladi, Mahmoud A. and Xie, Yuanyun and Skotte, Niels Henning and Ehrnhoefer, Dagmar E. and Graham, Rona K. and Kim, Jeong Eun and Bissada, Nagat and Yang, X. William and Paganetti, Paolo and Friedlander, Robert M. and Leavitt, Blair R. and Hayden, Michael R.
DOI: 10.1093/hmg/ddq026
2010

Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia
Experimental Biology and Medicine
Ding, Yi-Lei and Wang, Yu-Hui and Huang, Wei and Liu, George and Ross, Colin and Hayden, Michael R. and Yang, Jin-Kui
DOI: 10.1258/ebm.2009.009100
2010

HDL and LDL cholesterol significantly influence beta-cell function in type 2 diabetes mellitus
Current Opinion in Lipidology
Kruit, Janine K. and Brunham, Liam R. and Verchere, C. Bruce and Hayden, Michael R.
DOI: 10.1097/MOL.0b013e328339387b
2010

In Their Own Words: Reports of Stigma and Genetic Discrimination by People at Risk for Huntington Disease in the International RESPOND-HD Study
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Williams, Janet K. and Erwin, Cheryl and Juhl, Andrew R. and Mengeling, Michelle and Bombard, Yvonne and Hayden, Michael R. and Quaid, Kimberly and Shoulson, Ira and Taylor, Sandra and Paulsen, Jane S. and I-Respond-HD Investigators Hunting
DOI: 10.1002/ajmg.b.31080
2010

Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease
Neurology
Sturrock, A. and Laule, C. and Decolongon, J. and Santos, R. Dar and Coleman, A. J. and Creighton, S. and Bechtel, N. and Reilmann, R. and Hayden, M. R. and Tabrizi, S. J. and MacKay, A. L. and Leavitt, B. R.
DOI: 10.1212/WNL.0b013e3181fc27e4
2010

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia
Journal of Lipid Research
Olivecrona, Gunilla and Ehrenborg, Ewa and Semb, Henrik and Makoveichuk, Elena and Lindberg, Anna and Hayden, Michael R. and Gin, Peter and Davies, Brandon S. J. and Weinstein, Michael M. and Fong, Loren G. and Beigneux, Anne P. and Young, Stephen G. and Olivecrona, Thomas and Hernell, Olle
DOI: 10.1194/jlr.M002717
2010

Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis
Atherosclerosis
van Leuven, Sander I. and van Wijk, Diederik F. and Volger, Oscar L. and de Vries, Jean-Paul P. M. and van der Loos, Chris M. and de Kleijn, Dominique V. P. and Horrevoets, Anton J. G. and Tak, Paul P. and van der Wal, Allard C. and de Boer, Onno J. and Pasterkamp, Gerard and Hayden, Michael R. and Kastelein, John J. P. and Stroes, Erik S.
DOI: 10.1016/j.atherosclerosis.2010.01.043
2010

NP03, A LOW DOSE LITHIUM MICROEMULSION, IMPROVES MOTOR FUNCTION AND RESCUES STRIATAL PATHOLOGY WITHOUT TOXICITY IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
Journal of Neurology Neurosurgery and Psychiatry
Pouladi, M. A. and Brilluad, E. and Xie, Y. and Franciosi, S. and Zhang, W. N. and Zapala, M. and Compte, E. and Poucheret, P. and Maurel, J. C. and Neri, C. and Hayden, M. R.
DOI: 10.1136/jnnp.2010.222596.13
2010

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease
Neurobiology of Disease
Huang, Kun and Kang, Martin H. and Askew, Caitlin and Kang, Rujun and Sanders, Shaun S. and Wan, Junmei and Davis, Nicholas G. and Hayden, Michael R.
DOI: 10.1016/j.nbd.2010.05.027
2010

Perception, Experience, and Response to Genetic Discrimination in Huntington Disease: The International RESPOND-HD Study
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Erwin, Cheryl and Williams, Janet K. and Juhl, Andrew R. and Mengeling, Michelle and Mills, James A. and Bombard, Yvonne and Hayden, Michael R. and Quaid, Kimberly and Shoulson, Ira and Taylor, Sandra and Paulsen, Jane S. and I-RESPOND-HD Investigators Hunting
DOI: 10.1002/ajmg.b.31079
2010

PHARMACOGENOMICS
Acta Paediatrica
Hayden, M. R.
2010

Pharmacogenomics and active surveillance for serious adverse drug reactions in children
Pharmacogenomics
Loo, Tenneille T. and Ross, Colin J. D. and Sistonen, Johanna and Visscher, Henk and Madadi, Parvaz and Koren, Gideon and Hayden, Michael R. and Carleton, Bruce C.
DOI: 10.2217/pgs.10.111
2010

Phosphorylation of Huntingtin at Ser(421) in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A
Journal of Neuroscience
Metzler, Martina and Gan, Lu and Mazarei, Gelareh and Graham, Rona K. and Liu, Lili and Bissada, Nagat and Lu, Ge and Leavitt, Blair R. and Hayden, Michael R.
DOI: 10.1523/JNEUROSCI.1589-10.2010
2010

The Canadian Pharmacogenomics Network for Drug Safety: A Model for Safety Pharmacology
Thyroid
Ross, Colin J. D. and Visscher, Henk and Sistonen, Johanna and Brunham, Liam R. and Pussegoda, Kusala and Loo, Tenneille T. and Rieder, Michael J. and Koren, Gideon and Carleton, Bruce C. and Hayden, Michael R. and CPNDS Consortium
DOI: 10.1089/thy.2010.1642
2010

The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone
Peptides
Glier, Melissa B. and Pissios, Pavlos and Babich, Sandra L. and Macdonald, Marcia L. E. and Hayden, Michael R. and Maratos-Flier, Eleftheria and Gibson, William T.
DOI: 10.1016/j.peptides.2009.10.018
2010

Unstable Familial Transmissions of Huntington Disease Alleles With 27-35 CAG Repeats (Intermediate Alleles)
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Semaka, A. and Collins, J. A. and Hayden, M. R.
DOI: 10.1002/ajmg.b.30970
2010

Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
MacDonald, Marcia L. E. and Bissada, Nagat and Vallance, Bruce A. and Hayden, Michael R.
DOI: 10.1016/j.bbalip.2009.08.001
2009

Tissue-Specific Roles of ABCA1 Influence Susceptibility to Atherosclerosis
Arteriosclerosis Thrombosis and Vascular Biology
Brunham, Liam R. and Singaraja, Roshni R. and Duong, MyNgan and Timmins, Jenelle M. and Fievet, Catherine and Bissada, Nagat and Kang, Martin H. and Samra, Amrit and Fruchart, Jean-Charles and McManus, Bruce and Staels, Bart and Parks, John S. and Hayden, Michael R.
DOI: 10.1161/ATVBAHA.108.182303
2009

Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals
Pharmacoepidemiology and Drug Safety
Carleton, B. C. and Poole, R. L. and Smith, M. A. and Leeder, J. S. and Ghannadan, R. and Ross, C. J. D. and Phillips, M. S. and Hayden, M. R.
DOI: 10.1002/pds.1772
2009

Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease
Journal of Neuroscience
Joshi, Prasad R. and Wu, Nan-Ping and Andre, Veronique M. and Cummings, Damian M. and Cepeda, Carlos and Joyce, John A. and Carroll, Jeffrey B. and Leavitt, Blair R. and Hayden, Michael R. and Levine, Michael S. and Bamford, Nigel S.
DOI: 10.1523/JNEUROSCI.5687-08.2009
2009

Application of principal component analysis to pharmacogenomic studies in Canada
Pharmacogenomics Journal
Visscher, H. and Ross, C. J. D. and Dube, M-P and Brown, A. M. K. and Phillips, M. S. and Carleton, B. C. and Hayden, M. R.
DOI: 10.1038/tpj.2009.36
2009

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Nature Medicine
Okamoto, Shu-ichi and Pouladi, Mahmoud A. and Talantova, Maria and Yao, Dongdong and Xia, Peng and Ehrnhoefer, Dagmar E. and Zaidi, Rameez and Clemente, Arjay and Kaul, Marcus and Graham, Rona K. and Zhang, Dongxian and Chen, H-S Vincent and Tong, Gary and Hayden, Michael R. and Lipton, Stuart A.
DOI: 10.1038/nm.2056
2009

CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup
American Journal of Human Genetics
Warby, Simon C. and Montpetit, Alexandre and Hayden, Anna R. and Carroll, Jeffrey B. and Butland, Stefanie L. and Visscher, Flenk and Collins, Jennifer A. and Semaka, Alicia and Hudson, Thomas J. and Hayden, Michael R.
DOI: 10.1010/j.ajhg.2009.02.003
2009

Despite Antiatherogenic Metabolic Characteristics, SCD1-Deficient Mice Have Increased Inflammation and Atherosclerosis
Arteriosclerosis Thrombosis and Vascular Biology
MacDonald, Marcia L. E. and van Eck, Miranda and Hildebrand, Reeni B. and Wong, Brian W. C. and Bissada, Nagat and Ruddle, Piers and Kontush, Anatol and Hussein, Hala and Pouladi, Mahmoud A. and Chapman, M. John and Fievet, Catherine and van Berkel, Theo J. C. and Staels, Bart and McManus, Bruce M. and Hayden, Michael R.
DOI: 10.1161/ATVBAHA.108.181099
2009

Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease
Journal of Neuroscience
Graham, Rona K. and Pouladi, Mahmoud A. and Joshi, Prasad and Lu, Ge and Deng, Yu and Wu, Nan-Ping and Figueroa, Bryan E. and Metzler, Martina and Andre, Veronique M. and Slow, Elizabeth J. and Raymond, Lynn and Friedlander, Robert and Levine, Michael S. and Leavitt, Blair R. and Hayden, Michael R.
DOI: 10.1523/JNEUROSCI.5473-08.2009
2009

Enhanced atherothrombotic formation after oxidative injury by FeCl(3) to the common carotid artery in severe combined hyperlipidemic mice
Biochemical and Biophysical Research Communications
Xian, Xunde and Ding, Yu and Zhang, Ling and Wang, Yanan and McNutt, Michael A. and Ross, Colin and Hayden, Michael R. and Deng, Xuming and Liu, George
DOI: 10.1016/j.bbrc.2009.05.101
2009

Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells
Gut
Wang, Y. and Sternfeld, L. and Yang, F. and Rodriguez, J. A. and Ross, C. and Hayden, M. R. and Carriere, F. and Liu, G. and Hofer, W. and Schulz, I.
DOI: 10.1136/gut.2007.146258
2009

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection
Proceedings of the National Academy of Sciences of the United States of America
Yeretssian, Garabet and Doiron, Karine and Shao, Wei and Leavitt, Blair R. and Hayden, Michael R. and Nicholson, Donald W. and Saleh, Maya
DOI: 10.1073/pnas.0813362106
2009

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
Nature Genetics
Ross, Colin J. D. and Katzov-Eckert, Hagit and Dube, Marie-Pierre and Brooks, Beth and Rassekh, S. Rod and Barhdadi, Amina and Feroz-Zada, Yassamin and Visscher, Henk and Brown, Andrew M. K. and Rieder, Michael J. and Rogers, Paul C. and Phillips, Michael S. and Carleton, Bruce C. and Hayden, Michael R. and CPNDS Consortium
DOI: 10.1038/ng.478
2009

Genotypic Approaches to Therapy in Children (GATC): Using Information Technology to Improve Drug Safety
Advances in Information Technology and Communication in Health
Wong, E. and Carleton, B. C. and Wright, D. F. B. and Smith, M. A. and Verbeek, L. and Hildebrand, C. A. and Stannard, P. and Vaillancourt, R. and Elliot-Miller, P. and Ross, C. J. D. and Hayden, M. R. and McDaniel, JG
DOI: 10.3233/978-1-58603-979-0-209
2009

Haplotype Background, Repeat Length Evolution, and Huntington's Disease Response
American Journal of Human Genetics
Warby, Simon C. and Visscher, Henk and Butland, Stefanie and Pearson, Christopher E. and Hayden, Michael R.
DOI: 10.1016/j.ajhg.2009.11.006
2009

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Journal of Cell Biology
Thompson, Leslie Michels and Aiken, Charity T. and Kaltenbach, Linda S. and Agrawal, Namita and Illes, Katalin and Khoshnan, Ali and Martinez-Vincente, Marta and Arrasate, Montserrat and O'Rourke, Jacqueline Gire and Khashwji, Hasan and Lukacsovich, Tamas and Zhu, Ya-Zhen and Lau, Alice L. and Massey, Ashish and Hayden, Michael R. and Zeitlin, Scott O. and Finkbeiner, Steven and Green, Kim N. and LaFerla, Frank M. and Bates, Gillian and Huang, Lan and Patterson, Paul H. and Lo, Donald C. and Cuervo, Ana Maria and Marsh, J. Lawrence and Steffan, Joan S.
DOI: 10.1083/jcb.200909067
2009

Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease
Journal of Neuroscience
Fan, Jing and Cowan, Catherine M. and Zhang, Lily Y. J. and Hayden, Michael R. and Raymond, Lynn A.
DOI: 10.1523/JNEUROSCI.2491-09.2009
2009

Mouse models of Huntington disease: variations on a theme
Disease Models & Mechanisms
Ehrnhoefer, Dagmar E. and Butland, Stefanie L. and Pouladi, Mahmoud A. and Hayden, Michael R.
DOI: 10.1242/dmm.002451
2009

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells
Journal of Biological Chemistry
Ratovitski, Tamara and Gucek, Marjan and Jiang, Haibing and Chighladze, Ekaterine and Waldron, Elaine and D'Ambola, James and Hou, Zhipeng and Liang, Yideng and Poirier, Michelle A. and Hirschhorn, Ricky R. and Graham, Rona and Hayden, Michael R. and Cole, Robert N. and Ross, Christopher A.
DOI: 10.1074/jbc.M804813200
2009

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity
Faseb Journal
Huang, Kun and Sanders, Shaun and Singaraja, Roshni and Orban, Paul and Cijsouw, Tony and Arstikaitis, Pamela and Yanai, Anat and Hayden, Michael R. and El-Husseini, Alaa
DOI: 10.1096/fj.08-127399
2009

Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function
Circulation Research
Singaraja, Roshni R. and Kang, Martin H. and Vaid, Kuljeet and Sanders, Shaun S. and Vilas, Gonzalo L. and Arstikaitis, Pamela and Coutinho, Jonathan and Drisdel, Renaldo C. and El-Husseini, Alaa El Din and Green, William N. and Berthiaume, Luc and Hayden, Michael R.
DOI: 10.1161/CIRCRESAHA.108.193011
2009

Perceptions of genetic discrimination among people at risk for Huntington's disease: a cross sectional survey
British Medical Journal
Bombard, Yvonne and Veenstra, Gerry and Friedman, Jan M. and Creighton, Susan and Currie, Lauren and Paulsen, Jane S. and Bottorff, Joan L. and Hayden, Michael R. and Canadian Respond-HD Collaborative
DOI: 10.1136/bmj.b2175
2009

Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case-Control Study
Clinical Pharmacology & Therapeutics
Madadi, P. and Ross, C. J. D. and Hayden, M. R. and Carleton, B. C. and Gaedigk, A. and Leeder, J. S. and Koren, G.
DOI: 10.1038/clpt.2008.157
2009

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
Molecular and Cellular Neuroscience
Warby, Simon C. and Doty, Crystal N. and Graham, Rona K. and Shively, Jonathan and Singaraja, Roshni R. and Hayden, Michael R.
DOI: 10.1016/j.mcn.2008.09.007
2009

Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels
Journal of Lipid Research
Vaessen, S. F. C. and Dallinga-Thie, G. M. and Ross, C. J. D. and Splint, L. J. and Castellani, L. W. and Rensen, P. C. N. and Hayden, M. R. and Schaap, F. G. and Kuivenhoven, J. A.
DOI: 10.1194/jlr.M800551-JLR200
2009

Presynaptic defects impair learning and memory function in lipoprotein lipase deficient mice
Journal of Neurochemistry
Yu, J. and Liu, T. T. and Xian, X. D. and Wang, Y. H. and Miao, Y. F. and Zhang, J. J. and Yu, Y. and Ross, C. and Hayden, M. R. and Liu, G. and Chui, D. H.
2009

Presynaptic Defects Underlying Impaired Learning and Memory Function in Lipoprotein Lipase-Deficient Mice
Journal of Neuroscience
Xian, Xunde and Liu, Tingting and Yu, Jia and Wang, Yuhui and Miao, Yifei and Zhang, Jianjun and Yu, Yan and Ross, Colin and Karasinska, Joanna M. and Hayden, Michael R. and Liu, George and Chui, Dehua
DOI: 10.1523/JNEUROSCI.0297-09.2009
2009

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
Brain
Pouladi, Mahmoud A. and Graham, Rona K. and Karasinska, Joanna M. and Xie, Yuanyun and Santos, Rachelle Dar and Petersen, Asa and Hayden, Michael R.
DOI: 10.1093/brain/awp006
2009

Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function
Journal of Neuroscience
Karasinska, Joanna M. and Rinninger, Franz and Luetjohann, Dieter and Ruddle, Piers and Franciosi, Sonia and Kruit, Janine K. and Singaraja, Roshni R. and Hirsch-Reinshagen, Veronica and Fan, Jianjia and Brunham, Liam R. and Bissada, Nagat and Ramakrishnan, Rajasekhar and Wellington, Cheryl L. and Parks, John S. and Hayden, Michael R.
DOI: 10.1523/JNEUROSCI.4741-08.2009
2009

Tetrabenazine
Nature Reviews Drug Discovery
Hayden, Michael R. and Leavitt, Blair R. and Yasothan, Uma and Kirkpatrick, Peter
DOI: 10.1038/nrd2784
2009

The role of free fatty acids, pancreatic lipase and Ca(2+) signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice
Acta Physiologica
Yang, F. and Wang, Y. and Sternfeld, L. and Rodriguez, J. A. and Ross, C. and Hayden, M. R. and Carriere, F. and Liu, G. and Schulz, I.
DOI: 10.1111/j.1748-1716.2008.01933.x
2009

Acute hypertriglyceridemic pancreatitis during pregnancy due to homozygous lipoprotein lipase gene mutation
Clinica Chimica Acta
Bartha, Ivan and Dinya, Tamas and Seres, Ildiko and Paragh, Gyoergy and Ross, Colin and Hayden, Michael R. and Biro, Sandor and Vargha, Gyoergy
DOI: 10.1016/j.cca.2008.10.016
2009

A humanized BAC transgenic/knockout mouse model for human caspase-12 polymorphism
Cytokine
Yeretssian, Garabet and Hayden, Michael R. and Nicholson, Donald W. and Saleh, Maya
DOI: 10.1016/j.cyto.2008.07.091
2008

Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet
Circulation Research
Zhang, Xiaohong and Qi, Rong and Xian, Xunde and Yang, Fei and Blackstein, Michael and Deng, Xuming and Fan, Jianglin and Ross, Colin and Karasinska, Joanna and Hayden, Michael R. and Liu, George
DOI: 10.1161/CIRCRESAHA.107.156554
2008

A toxicogenetic case-control study of codeine toxicity during breastfeeding
Clinical Pharmacology & Therapeutics
Madadi, P. and Ross, C. J. and Pape, T. and Gaedigk, A. and Carleton, B. C. and Hayden, M. R. and Leeder, S. J. and Korens, G.
2008

A toxicogenetic case-control study of codeine toxicity during breastfeeding.
Clinical Pharmacology & Therapeutics
Madadi, P. and Ross, C. J. and Pape, T. and Gaedigk, A. and Carleton, B. C. and Hayden, M. R. and Leeder, S. J. and Korens, G.
2008

ABCA1 Gene Mutations, HDL Cholesterol Levels, and Risk of Ischemic Heart Disease
Jama-Journal of the American Medical Association
Brunham, Liam R. and Kastelein, John J. P. and Hayden, Michael R.
DOI: 10.1001/jama.2008.539
2008

Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice
Journal of Lipid Research
MacDonald, Marcia L. E. and Singaraja, Roshni R. and Bissada, Nagat and Ruddle, Piers and Watts, Russell and Karasinska, Joanna M. and Gibson, William T. and Fievet, Catherine and Vance, Jean E. and Staels, Bart and Hayden, Michael R.
DOI: 10.1194/jlr.M700478-JLR200
2008

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
Human Molecular Genetics
Wang, Chuan-En and Tydlacka, Suzanne and Orr, Adam L. and Yang, Shang-Hsun and Graham, Rona K. and Hayden, Michael R. and Li, Shihua and Chan, Anthony W. S. and Li, Xiao-Jiang
DOI: 10.1093/hmg/ddn175
2008

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
Human Molecular Genetics
Warby, Simon C. and Doty, Crystal N. and Graham, Rona K. and Carroll, Jeffrey B. and Yang, Yu-Zhou and Singaraja, Roshni R. and Overall, Christopher M. and Hayden, Michael R.
DOI: 10.1093/hmg/ddn139
2008

Activation of caspase-6 is an early event in acute and chronic models of Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Graham, R. K. and Deng, Y. and Vaid, K. and Bissada, N. and Murphy, Z. and Wang, L. and Hayden, M. R.
2008

Automated deformation analysis in the YAC128 Huntington disease mouse model
Neuroimage
Lerch, Jason P. and Carroll, Jeffrey B. and Spring, Shoshana and Bertram, Lisa N. and Schwab, Claudia and Hayden, Michael R. and Henkelman, R. Mark
DOI: 10.1016/j.neuroimage.2007.08.033
2008

Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic Beta Cell Dysfunction
Circulation
Vergeer, Menno and Brunham, Liam R. and Koetsveld, Joris and Kruit, Janine K. and Verchere, C. B. and Kastelein, John J. and Hayden, Michael R. and Stroes, Erik S.
2008

Caspases-2 and 6 as drug targets in Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Carroll, J. B. and Ehrnhoefer, D. E. and Graham, R. K. and Cao, L-P and Hayden, M. R.
2008

Cholesterol in islet dysfunction and type 2 diabetes
Journal of Clinical Investigation
Brunham, Liam R. and Kruit, Janine K. and Verchere, C. Bruce and Hayden, Michael R.
DOI: 10.1172/JCI33296
2008

Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease
Neuroimage
Lerch, Jason P. and Carroll, Jeffrey B. and Dorr, Adrienne and Spring, Shoshana and Evans, Alan C. and Hayden, Michael R. and Sled, John G. and Henkelman, R. Mark
DOI: 10.1016/j.neuroimage.2008.02.019
2008

Detection of Huntington's disease decades before diagnosis: the Predict-HD study
Journal of Neurology Neurosurgery and Psychiatry
Paulsen, J. S. and Langbehn, D. R. and Stout, J. C. and Aylward, E. and Ross, C. A. and Nance, M. and Guttman, M. and Johnson, S. and MacDonald, M. and Beglinger, L. J. and Duff, K. and Kayson, E. and Biglan, K. and Shoulson, I. and Oakes, D. and Hayden, M. and Predict, H. D. Investigators and Coordin,
DOI: 10.1136/jnnp.2007.128728
2008

Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease
European Journal of Human Genetics
Bombard, Yvonne and Penziner, Elizabeth and Suchowersky, Oksana and Guttman, Mark and Paulsen, Jane S. and Bottorff, Joan L. and Hayden, Michael R.
DOI: 10.1038/sj.ejhg.5201937
2008

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease
Neurobiology of Disease
Zhang, Hua and Li, Qin and Graham, Rona K. and Slow, Elizabeth and Hayden, Michael R. and Bezprozvannya, Ilya
DOI: 10.1016/j.nbd.2008.03.010
2008

Intermediate alleles for Huntington's disease: Patient understanding and current genetic counselling practices
Journal of Neurology Neurosurgery and Psychiatry
Semaka, A. and Balneaves, L. and Hayden, M. R.
2008

Intramuscular Administration of AAV1-Lipoprotein Lipase(S447X) Lowers Triglycerides in Lipoprotein Lipase-Deficient Patients
Arteriosclerosis Thrombosis and Vascular Biology
Stroes, Erik S. and Nierman, Melchior C. and Meulenberg, Janneke J. and Franssen, Remco and Twisk, Jaap and Henny, C. Pieter and Maas, Mario M. and Zwinderman, Aeilko H. and Ross, Colin and Aronica, Eleonora and High, Katherine A. and Levi, Marcel M. and Hayden, Michael R. and Kastelein, John J. and Kuivenhoven, Jan Albert
DOI: 10.1161/ATVBAHA.108.175620
2008

Is LPL deficiency atherogenic? Response
Circulation Research
Liu, George and Hayden, Michael R.
DOI: 10.1161/CIRCRESAHA.108.178715
2008

Mechanisms of altered N-methyl-D-aspartate receptor-mediated calcium signaling in the YAC mouse model of Huntington's disease
Journal of General Physiology
Milnerwood, A. and Gladding, C. and Hayden, M. R. and Murphy, T. H. and Raymond, L. A.
2008

Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Penziner, Elizabeth and Williams, Janet K. and Erwin, Cheryl and Bombard, Yvonne and Wallis, Anne and Beglinger, Leigh J. and Hayden, Michael R. and Paulsens, Jane S.
DOI: 10.1002/ajmg.b.30600
2008

Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity
Journal of Neuroscience
Cowan, Catherine M. and Fan, Mannie M. Y. and Fan, Jing and Shehadeh, Jacqueline and Zhang, Lily Y. J. and Graham, Rona K. and Hayden, Michael R. and Raymond, Lynn A.
DOI: 10.1523/JNEUROSCI.4619-08.2008
2008

Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors
Journal of Neurochemistry
Fan, Mannie M. Y. and Zhang, Hong and Hayden, Michael R. and Pelech, Steven L. and Raymond, Lynn A.
DOI: 10.1111/j.1471-4159.2007.05016.x
2008

Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats
Movement Disorders
Semaka, Alicia and Warby, Simon and Leavit, Bliar R. and Hayden, Michael R.
DOI: 10.1002/mds.21820
2008

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Journal of Experimental Medicine
Bjorkqvist, Maria and Wild, Edward J. and Thiele, Jenny and Silvestroni, Aurelio and Andre, Ralph and Lahiri, Nayana and Raibon, Elsa and Lee, Richard V. and Benn, Caroline L. and Soulet, Denis and Magnusson, Anna and Woodman, Ben and Landles, Christian and Pouladi, Mahmoud A. and Hayden, Michael R. and Khalili-Shirazi, Azadeh and Lowdell, Mark W. and Brundin, Patrik and Bates, Gillian P. and Leavitt, Blair R. and Moller, Thomas and Tabrizi, Sarah J.
DOI: 10.1084/jem.20080178
2008

Evaluation of recombinant AAV1 produced in insect cells for muscle-directed gene transfer
Human Gene Therapy
Twisk, Jaap and Ross, Colin J. D. and Comijn, Lizzy and Biesmans, Dennis and Haast, Saskia and Bakker, Andrew C. and Van Amersfoort, Edwin S. and Van Deventer, Sander J. H. and Meulenberg, Janneke J. M. and Hayden, Michael R. and Hermens, Wim T.
2007

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation
Human Molecular Genetics
Valenza, Marta and Carroll, Jeffrey B. and Leoni, Valerio and Bertram, Lisa N. and Bjorkhem, Ingeman and Singaraja, Roshni R. and Di Donato, Stefano and Lutjohann, Dieter and Hayden, Michael R. and Cattaneo, Elena
DOI: 10.1093/hmg/ddm170
2007

Genotypic approaches to therapy in children - A national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children
Autoimmunity, Pt B: Novel Applications of Basic Research
Ross, Colin J. D. and Carleton, Bruce and Warn, Dana G. and Stenton, Sunita B. and Rassekh, Shahrad Rod and Hayden, Michael R. and Gershwin, ME and Shoenfeld, Y
DOI: 10.1196/annals.1423.020
2007

Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease
Neuroscience
Benn, C. L. and Slow, E. J. and Farrell, L. A. and Graham, R. and Deng, Y. and Hayden, M. R. and Cha, J.-H. J.
DOI: 10.1016/j.neuroscience.2007.03.010
2007

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity
Journal of Neuroscience
Parker, J. Alex and Metzler, Martina and Georgiou, John and Mage, Marilyne and Roder, John C. and Rose, Ann M. and Hayden, Michael R. and Neri, Christian
DOI: 10.1523/JNEUROSCI.1941-07.2007
2007

Lessons learned on the design of a pharmacogenomic study
Pharmacoepidemiology and Drug Safety
Dube, Marie-Pierre and Aeschliman, Dana S. and Carleton, Bruce C. and Hayden, Michael R.
2007

Loss-of-function mutations in the Na(v)1.7 gene underlie congenital indifference to pain in multiple human populations
Clinical Genetics
Goldberg, Y. P. and MacFarlane, J. and MacDonald, M. L. and Thompson, J. and Dube, M-P and Mattice, M. and Fraser, R. and Young, C. and Hossain, S. and Pape, T. and Payne, B. and Radomski, C. and Donaldson, G. and Ives, E. and Cox, J. and Younghusband, H. B. and Green, R. and Duff, A. and Boltshauser, E. and Grinspan, G. A. and Dimon, J. H. and Sibley, B. G. and Andria, G. and Toscano, E. and Kerdraon, J. and Bowsher, D. and Pimstone, S. N. and Samuels, M. E. and Sherrington, R. and Hayden, M. R.
DOI: 10.1111/j.1399-0004.2007.00790.x
2007

Managing genetic discrimination: Strategies used by individuals found to have the Huntington disease mutation
Clinical Genetics
Bombard, Y. and Penziner, E. and Decolongon, J. and Klimek, M. L. N. and Creighton, S. and Suchowersky, O. and Guttman, M. and Paulsen, J. S. and Bottorff, J. L. and Hayden, M. R.
DOI: 10.1111/j.1399-0004.2007.00770.x
2007

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease
Journal of Neuroscience
Fernandes, Herman B. and Baimbridge, Kenneth G. and Church, John and Hayden, Michael R. and Raymond, Lynn A.
DOI: 10.1523/JNEUROSCI.3455-07.2007
2007

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
Human Molecular Genetics
Kuhn, Alexandre and Goldstein, Darlene R. and Hodges, Angela and Strand, Andrew D. and Sengstag, Thierry and Kooperberg, Charles and Becanovic, Kristina and Pouladi, Mahmoud A. and Sathasivam, Kirupa and Cha, Jang-Ho J. and Hannan, Anthony J. and Hayden, Michael R. and Leavitt, Blair R. and Dunnett, Stephen B. and Ferrante, Robert J. and Albin, Roger and Shelbourne, Peggy and Delorenzi, Mauro and Augood, Sarah J. and Faull, Richard L. M. and Olson, James M. and Bates, Gillian P. and Jones, Lesley and Luthi-Carter, Ruth
DOI: 10.1093/hmg/ddm133
2007

Mycophenolate mofetil and atherosclerosis - Results of animal and human studies
Autoimmunity, Pt B: Novel Applications of Basic Research
Gibson, William Thomas and Hayden, Michael Reuben and Gershwin, ME and Shoenfeld, Y
DOI: 10.1196/annals.1423.023
2007

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease
Cell Cycle
Ratovitski, Tamara and Nakamura, Masayuki and D'Ambola, James and Chighladze, Ekaterine and Liang, Yideng and Wang, Wenfei and Graham, Rona and Hayden, Michael R. and Borchelt, David R. and Hirschhorn, Ricky R. and Ross, Christopher A.
2007

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1
Journal of Neuroscience
Metzler, Martina and Gan, Lu and Wong, Tak Pan and Liu, Lidong and Helm, Jeffrey and Liu, Lili and Georgiou, John and Wang, Yushan and Bissada, Nagat and Cheng, Kevin and Roder, John C. and Wang, Yu Tian and Hayden, Michael R.
DOI: 10.1523/JNEUROSCI.5175-06.2007
2007

Pharmacogenomics and its implications for autoimmune disease
Journal of Autoimmunity
Ross, Colin J. D. and Katzov, Hagit and Carleton, Bruce and Hayden, Michael R.
DOI: 10.1016/j.jaut.2007.02.008
2007

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
Neurobiology of Disease
Van Raamsdonk, Jeremy M. and Metzler, Martina and Slow, Elizabeth and Pearson, Jacqueline and Schwab, Claudia and Carroll, Jeffrey and Graham, Rona K. and Leavitt, Blair R. and Hayden, Michael R.
DOI: 10.1016/j.nbd.2006.12.010
2007

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo
Journal of Lipid Research
Hirsch-Reinshagen, Veronica and Chan, Jennifer Y. and Wilkinson, Anna and Tanaka, Tracie and Fan, Jianjia and Ou, George and Maia, Luis F. and Singaraja, Roshni R. and Hayden, Michael R. and Wellington, Cheryl L.
DOI: 10.1194/jlr.M600543-JLR200
2007

Predictive testing for Huntington disease: interpretation and significance of intermediate alleles. (vol 70, pg 283, 2006)
Clinical Genetics
Semaka, A. and Creighton, S. and Warby, S. and Hayden, M. R.
2007

Selective degeneration in YAC mouse models of Huntington disease
Brain Research Bulletin
Van Raamsdonk, Jeremy M. and Warby, Simon C. and Hayden, Michael R.
DOI: 10.1016/j.brainresbull.2006.10.018
2007

Spontanous atherosclerosis in old LPL-Deficient mice with severe hypertriglyceridemia on a normal chow diet
Arteriosclerosis Thrombosis and Vascular Biology
Zhang, Xiaohong and Qi, Rong and Xian, Xunde and Huang, Wei and Fan, Jianglin and Ross, Colin and Hayden, Michael R. and Liu, George
2007

Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1(-/-) mice
Molecular Reproduction and Development
Khatchadourian, Karine and Smith, Charles E. and Metzler, Martina and Gregory, Mary and Hayden, Michael R. and Cyr, Daniel G. and Hermo, Louis
DOI: 10.1002/mrd.20564
2007

Testicular degeneration in Huntington disease
Neurobiology of Disease
Van Raamsdonk, Jeremy M. and Murphy, Zoe and Selva, David M. and Hamidizadeh, Reza and Pearson, Jacqueline and Petersen, Asa and Bjorkqvist, Maria and Muir, Cameron and Mackenzie, Ian R. and Hammond, Geoffrey L. and Vogl, A. Wayne and Hayden, Michael R. and Leavitt, Blair R.
DOI: 10.1016/j.nbd.2007.01.006
2007

Verbal episodic memory declines prior to diagnosis in Huntington's disease
Neuropsychologia
Solomon, Andrea C. and Stout, Julie C. and Johnson, Shannon A. and Langbehn, Douglas R. and Aylward, Elizabeth H. and Brandt, Jason and Ross, Christopher A. and Beglinger, Leigh and Hayden, Michael R. and Kieburtz, Karl and Kayson, Elise and Julian-Baros, Elaine and Duff, Kevin and Guttman, Mark and Nance, Martha and Oakes, David and Shoulson, Ira and Penziner, Elizabeth and Paulsen, Jane S. and Predict-HD Investigators
DOI: 10.1016/j.neuropsychologia.2006.12.015
2007

When good drugs go bad
Nature
Giacomini, Kathleen M. and Krauss, Ronald M. and Roden, Dan M. and Eichelbaum, Michel and Hayden, Michael R.
DOI: 10.1038/446975a
2007

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease
Journal of Neuroscience
Fan, Mannie M. Y. and Fernandes, Herman B. and Zhang, Lily Y. J. and Hayden, Michael R. and Raymond, Lynn A.
DOI: 10.1523/JNEUROSCI.4356-06.2007
2007

beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
Nature Medicine
Brunham, Liam R. and Kruit, Janine K. and Pape, Terry D. and Timmins, Jenelle M. and Reuwer, Anne Q. and Vasanji, Zainisha and Marsh, Brad J. and Rodrigues, Brian and Johnson, James D. and Parks, John S. and Verchere, C. Bruce and Hayden, Michael R.
DOI: 10.1038/nm1546
2007

Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease
Brain
Johnson, Shannon A. and Stout, Julie C. and Solomon, Andrea C. and Langbehn, Douglas R. and Aylward, Elizabeth H. and Cruce, Christina B. and Ross, Christopher A. and Nance, Martha and Kayson, Elise and Julian-Baros, Elaine and Hayden, Michael R. and Kieburtz, Karl and Guttman, Mark and Oakes, David and Shoulson, Ira and Beglinger, Leigh and Duff, Kevin and Penziner, Elizabeth and Paulsen, Jane S. and Predict-HD Investigators H S G
DOI: 10.1093/brain/awm107
2007

CAG-encoded polyglutamine length polymorphism in the human genome
Bmc Genomics
Butland, Stefanie L. and Devon, Rebecca S. and Huang, Yong and Mead, Carri-Lyn and Meynert, Alison M. and Neal, Scott J. and Lee, Soo Sen and Wilkinson, Anna and Yang, George S. and Yuen, Macaire M. S. and Hayden, Michael R. and Holt, Robert A. and Leavitt, Blair R. and Ouellette, B. F. Francis
DOI: 10.1186/1471-2164-8-126
2007

Canadian national active surveillance network for adverse drug reactions: Genotypic approaches to therapy in children (GATC): The first year
Pharmacoepidemiology and Drug Safety
Carleton, B. C. and Warn, D. and Stenton, S. and Rassekh, R. and Smith, M. A. and Dhami, B. and Ross, C. and Hayden, M. R.
2007

Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice
Arteriosclerosis Thrombosis and Vascular Biology
Wang, Jinyu and Xian, Xunde and Huang, Wei and Chen, Li and Wu, Liling and Zhu, Yi and Fan, Jianglin and Ross, Colin and Hayden, Michael R. and Liu, George
DOI: 10.1161/01.ATV.0000249683.80414.d9
2007

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease
Bmc Neuroscience
Van Raamsdonk, Jeremy M. and Pearson, Jacqueline and Murphy, Zoe and Hayden, Michael R. and Leavitt, Blair R.
DOI: 10.1186/1471-2202-7-80
2006

Wild-type huntingtin protects neurons from excitotoxicity
Journal of Neurochemistry
Leavitt, BR and van Raamsdonk, JM and Shehadeh, J and Fernandes, H and Murphy, Z and Graham, RK and Wellington, CL and Raymond, LA and Hayden, MR
DOI: 10.1111/j.1471-4159.2005.03605.x
2006

A gene therapy approach to treat human lipoprotein lipase deficiency
Atherosclerosis Supplements
Nierman, M. C. and Stroes, E. S. and Twisk, J. and Rip, J. and Dijkhuizen, P. and Ross, C. J. D. and Bakker, A. C. and Hermens, W. T. and Meulenberg, J. M. and Hayden, M. R. and Kastelein, J. J. P. and Kuivenhoven, J. A.
DOI: 10.1016/S1567-5688(06)80052-8
2006

Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities
Proceedings of the National Academy of Sciences of the United States of America
Devon, RS and Orban, PC and Gerrow, K and Barbieri, MA and Schwab, C and Cao, LP and Helm, JR and Bissada, N and Cruz-Aguado, R and Davidson, TL and Witmer, J and Metzler, M and Lam, CK and Tetzlaff, W and Simpson, EM and McCaffery, JM and El-Husseini, AE and Leavitt, BR and Hayden, MR
DOI: 10.1073/pnas.0510197103
2006

Body weight is modulated by levels of full-length Huntingtin
Human Molecular Genetics
Van Raamsdonk, JM and Gibson, WT and Pearson, J and Murphy, Z and Lu, G and Leavitt, BR and Hayden, MR
DOI: 10.1093/hmg/ddl072
2006

Both hepatic and extrahepatic ABCA1 are essential for the maintenance of plasma HDL-C levels in vivo
Atherosclerosis Supplements
Singaraja, R. R. and Van Eck, M. and Fievet, C. and Hayden, M. R.
DOI: 10.1016/S1567-5688(06)82182-3
2006

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo
Circulation
Singaraja, Roshni R. and Van Eck, Miranda and Bissada, Nagat and Zimetti, Francesca and Collins, Heidi L. and Hildebrand, Reeni B. and Hayden, Anna and Brunham, Liam R. and Kang, Martin H. and Fruchart, Jean-Charles and Van Berkel, Theo J. C. and Parks, John S. and Staels, Bart and Rothblat, George H. and Fievet, Catherine and Hayden, Michael R.
DOI: 10.1161/CIRCULATIONAHA.106.621433
2006

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease
Neurobiology of Disease
Kishikawa, S. and Li, J. L. and Gillis, T. and Hakky, M. M. and Warby, S. and Hayden, M. and MacDonald, M. E. and Myers, R. H. and Gusella, J. F.
DOI: 10.1016/j.nbd.2006.07.008
2006

Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease
Clinical Genetics
Bjorkqvist, M and Petersen, A and Carroll, J and Nielsen, J and Ecker, D and Mulder, H and Hayden, MR and Landwehrmeyer, B and Brundin, P and Leavitt, BR
DOI: 10.1111/j.1399-0004.2006.00636.x
2006

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
Cell
Graham, RK and Deng, Y and Slow, EJ and Haigh, B and Bissada, N and Lu, G and Pearson, J and Shehadeh, J and Bertram, L and Murphy, Z and Warby, SC and Doty, CN and Roy, S and Wellinpton, CL and Leavitt, BR and Raymond, LA and Nicholson, DW and Hayden, MR
DOI: 10.1016/j.cell.2006.04.026
2006

Comparative assessment of seminal traits, ovarian responsiveness and in vitro fertilization in 15 domestic cat models of hereditary disease.
Biology of Reproduction
Magarey, Genevieve M. and Bond, Jennifer B. and Bateman, Helen L. and Haskins, Mark E. and Fyfe, John C. and Baker, Henry J. and Hayden, Michael R. and Ross, Colin J. and Lyons, Leslie A. and Swanson, William F.
2006

Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation
Human Gene Therapy
Ross, CJD and Twisk, J and Bakker, AC and Miao, F and Verbart, D and Rip, J and Godbey, T and Dijkhuizen, P and Hermens, WTJMC and Kastelein, JJP and Kuivenhoven, JA and Meulenberg, JM and Hayden, MR
DOI: 10.1089/hum.2006.17.487
2006

Critical role of ATP-binding cassette transporter a1 (ABCA1) in beta-cell function and glucose homeostasis
Circulation
Brunham, Liam and Pape, Terry and Soukhatcheva, Galina and Verchere, Bruce and Hayden, Michael R.
2006

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
Neurobiology of Disease
Guidetti, P and Bates, GP and Graham, RK and Hayden, MR and Leavitt, BR and MacDonald, ME and Slow, EJ and Wheeler, VC and Woodman, B and Schwarcz, R
DOI: 10.1016/j.nbd.2006.02.011
2006

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma
Neurobiology of Disease
Burgess, Braydon L. and McIsaac, Sean A. and Naus, Kathryn E. and Chan, Jeniffer Y. and Tansley, Gavin H. K. and Yang, Jing and Miao, Fudan and Ross, Colin J. D. and van Eck, Miranda and Hayden, Michael R. and van Nostrand, William and St. George-Hyslop, Peter and Westaway, David and Wellington, Cheryl L.
DOI: 10.1016/j.nbd.2006.06.007
2006

FASA-57 cDNA shares no homology with coding sequence of HD gene
Journal of Reproductive Immunology
Warby, S. and MacDonald, M. and Hayden, M. and Butland, S. and Ouellette, F.
DOI: 10.1016/j.jri.2005.10.002
2006

Gene therapy with lipoprotein lipase variant S447X - Response
Arteriosclerosis Thrombosis and Vascular Biology
Ross, CJD and Twisk, J and Kuivenhoven, JA and Rip, J and Kastelein, JJ and Hayden, MR
2006

Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study
Bmc Medical Genetics
Li, Jian-Liang and Hayden, Michael R. and Warby, Simon C. and Durr, Alexandra and Morrison, Patrick J. and Nance, Martha and Ross, Christopher A. and Margolis, Russell L. and Rosenblatt, Adam and Squitieri, Ferdinando and Frati, Luigi and Gomez-Tortosa, Estrella and Garcia, Carmen Ayuso and Suchowersky, Oksana and Klimek, Mary Lou and Trent, Ronald J. A. and McCusker, Elizabeth and Novelletto, Andrea and Frontali, Marina and Paulsen, Jane S. and Jones, Randi and Ashizawa, Tetsuo and Lazzarini, Alice and Wheeler, Vanessa C. and Prakash, Ranjana and Xu, Gang and Djousse, Luc and Mysore, Jayalakshmi Srinidhi and Gillis, Tammy and Hakky, Michael and Cupples, Adrienne and Saint-Hilaire, Marie H. and Cha, Jang-Ho J. and Hersch, Steven M. and Penney, John B. and Harrison, Madaline B. and Perlman, Susan L. and Zanko, Andrea and Abramson, Ruth K. and Lechich, Anthony J. and Duckett, Ayana and Marder, Karen and Conneally, P. Michael and Gusella, James F. and MacDonald, Marcy E. and Myers, Richard H.
DOI: 10.1186/1471-2350-7-71
2006

Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia
Biochemical and Biophysical Research Communications
Zhao, TQ and Guo, J and Li, H and Huang, W and Xian, XD and Ross, CJD and Hayden, MR and Wen, ZY and Liu, G
DOI: 10.1016/j.bbrc.2006.01.067
2006

Hepatic ABCA1 is a key molecule in HDL cholesteryl ester metabolism in mice
Atherosclerosis Supplements
Brundert, M. and Singaraja, R. R. and Stahmer, B. and Parks, J. S. and Hayden, M. R. and Rinninger, F.
DOI: 10.1016/S1567-5688(06)80651-3
2006

Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice
Arteriosclerosis Thrombosis and Vascular Biology
Singaraja, Roshni R. and Stahmer, Bjorn and Brundert, May and Merkel, Martin and Heeren, Joerg and Bissada, Nagat and Kang, Martin and Timmins, Jenelle M. and Ramakrishnan, Rajasekhar and Parks, John S. and Hayden, Michael R. and Rinninger, Franz
DOI: 10.1161/01.ATV.0000229219.13757.a2
2006

Hippi is essential for node cilia assembly and Sonic hedgehog signaling
Developmental Biology
Houde, Caroline and Dickinson, Robin J. and Houtzager, Vicky M. and Cullum, Rebecca and Montpetit, Rachel and Metzler, Martina and Simpson, Elizabeth M. and Roy, Sophie and Hayden, Michael R. and Hoodless, Pamela A. and Nicholson, Donald W.
DOI: 10.1016/j.ydbio.2006.09.001
2006

Huntingtin inhibits caspase-3 activation
Embo Journal
Zhang, Yu and Leavitt, Blair R. and van Raamsdonk, Jeremy M. and Dragatsis, Ioannis and Goldowitz, Dan and MacDonald, Marcy E. and Hayden, Michael R. and Friedlander, Robert M.
DOI: 10.1038/sj.emboj.7601445
2006

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
Journal of Clinical Investigation
Brunham, LR and Kruit, JK and Iqbal, J and Fievet, C and Timmins, JM and Pape, TD and Coburn, BA and Bissada, N and Staels, B and Groen, AK and Hussain, MM and Parks, JS and Kuipers, F and Hayden, MR
DOI: 10.1172/JCI27352
2006

Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?
Nature Clinical Practice Neurology
Leavitt, B. R. and Hayden, M. R.
DOI: 10.1038/ncpneuro0299
2006

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models
Neurobiology of Disease
Graham, RK and Slow, EJ and Deng, Y and Bissada, N and Lu, G and Pearson, J and Shehadeh, J and Leavitt, BR and Raymond, LA and Hayden, MR
DOI: 10.1016/j.nbd.2005.08.007
2006

Lipoprotein lipase S447X - A naturally occurring gain-of-function mutation
Arteriosclerosis Thrombosis and Vascular Biology
Rip, J and Nierman, MC and Ross, CJ and Jukema, JW and Hayden, MR and Kastelein, JJP and Stroes, ESG and Kuivenhoven, JA
DOI: 10.1161/01.ATV.0000219283.10832.43
2006

Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice
Arteriosclerosis Thrombosis and Vascular Biology
Van Eck, M and Singaraja, RR and Ye, D and Hildebrand, RB and James, ER and Hayden, MR and Van Berkel, TJC
DOI: 10.1161/01.ATV.0000208364.22732.16
2006

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: Effect of histone deacetylase inhibitors
Journal of Neuroscience
Oliveira, Jorge M. A. and Chen, Sylvia and Almeida, Sandra and Riley, Rebeccah and Goncalves, Jorge and Oliveira, Catarina R. and Hayden, Michael R. and Nicholls, David G. and Ellerby, Lisa M. and Rego, A. Cristina
DOI: 10.1523/JNEUROSCI.3004-06.2006
2006

Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH
Proceedings of the National Academy of Sciences of the United States of America
Bae, Y and Hara, MR and Cascio, MB and Wellington, CL and Hayden, MR and Ross, CA and Ha, HC and Li, XJ and Snyder, SH and Sawa, A
DOI: 10.1073/pnas.0511316103
2006

Mycophenolate mofetil (MMF): Firing at the atherosclerotic plaque from different angles?
Cardiovascular Research
van Leuven, SI and Kastelein, JJP and Allison, AC and Hayden, MR and Stroes, ESG
DOI: 10.1016/j.cardiores.2005.09.018
2006

Mycophenolate mofetil and animal models
Lupus
Gibson, W. T. and Hayden, M. R.
DOI: 10.1177/0961203306071675
2006

Mycophenolate mofetil as an immunomodulatory silver bullet in atherogenesis?
Lupus
van Leuven, S. I. and Kastelein, J. J. P. and Hayden, M. R. and Stroes, E. S.
DOI: 10.1177/0961203306071670
2006

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function
Nature Neuroscience
Yanai, A and Huang, K and Kang, RJ and Singaraja, RR and Arstikaitis, P and Gan, L and Orban, PC and Mullard, A and Cowan, CM and Raymond, LA and Drisdel, RC and Green, WN and Ravikumar, B and Rubinsztein, DC and El-Husseini, A and Hayden, MR
DOI: 10.1038/nn1702
2006

Predictive testing for Huntington disease: interpretation and significance of intermediate alleles
Clinical Genetics
Semaka, A. and Creighton, S. and Warby, S. and Hayden, M. R.
DOI: 10.1111/j.1399-0004.2006.00668.x
2006

Preparing for preventive clinical trials - The predict-HD study
Archives of Neurology
Paulsen, J. S. and Hayden, M. and Stout, J. C. and Langbehn, D. R. and Aylward, E. and Ross, C. A. and Guttman, M. and Nance, M. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Kayson, E. and Johnson, S. and Penziner, E. and Predict, H. D. Investigators
DOI: 10.1001/archneur.63.6.883
2006

Selective deficiency of hepatic ABCA1 results in increased susceptibility to atherosclerosis
Circulation
Brunham, Liam and Timmins, Jenelle M. and Pape, Terry D. and Duong, MyNgan and Parks, John S. and Hayden, Michael R.
2006

Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro
Circulation Research
Singaraja, Roshni R. and Visscher, Henk and James, Erick R. and Chroni, Angeliki and Coutinho, Jonathan M. and Brunham, Liam R. and Kang, Martin H. and Zannis, Vassilis I. and Chimini, Giovanna and Hayden, Michael R.
DOI: 10.1161/01.RES.0000237920.70451.ad
2006

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
Neurobiology of Disease
Shehadeh, J and Femandes, HB and Mullins, MMZ and Graham, RK and Leavitt, BR and Hayden, MR and Raymond, LA
DOI: 10.1016/j.nbd.2005.08.001
2006

Testicular degeneration in Huntington's disease
Movement Disorders
Leavitt, B. R. and Van Raamsdonk, J. M. and Murphy, Z. and Vogl, A. and Mackenzie, L. and Petersen, A. and Bjorkqvist, M. and Muir, C. and Hayden, M. R.
2006

Tissue-specific induction of intestinal ABCA1 expression with a liver x receptor agonist raises plasma HDL cholesterol levels
Circulation Research
Brunham, Liam R. and Kruit, Janine K. and Pape, Terry D. and Parks, John S. and Kuipers, Folkert and Hayden, Michael R.
DOI: 10.1161/01.RES.0000244014.19589.8e
2006

To be or not to be toxic: aggregations in Huntington and Alzheimer disease
Trends in Genetics
Slow, Elizabeth J. and Graham, Rona K. and Hayden, Michael R.
DOI: 10.1016/j.tig.2006.05.008
2006

Variations on a gene: Rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis
Annual Review of Nutrition
Brunham, Liam R. and Singaraja, Roshni R. and Hayden, Michael R.
DOI: 10.1146/annurev.nutr.26.061505.111214
2006

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
Proceedings of the National Academy of Sciences of the United States of America
Slow, EJ and Graham, RK and Osmand, AP and Devon, RS and Lu, G and Deng, Y and Pearson, J and Vaid, K and Bissada, N and Wetzel, R and Leavitt, BR and Hayden, MR
DOI: 10.1073/pnas.0503634102
2005

W10 regulation of plasma HDL levels and metabolism
Atherosclerosis Supplements
Van Berkel, T. and Out, R. and Hoekstra, M. and Hildebrand, R. B. and Kruijt, K. and Singaraja, R. and Kaminski, W. E. and Schmitz, G. and Hayden, M. and Van Eck, M.
DOI: 10.1016/s1567-5688(05)80183-7
2005

Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1
Journal of Lipid Research
Singaraja, RR and James, ER and Crim, J and Visscher, H and Chatterjee, A and Hayden, MR
DOI: 10.1194/jlr.M500133-JLR200
2005

Cardiovascular disease in systemic lupus erythematosus: has the time for action come?
Current Opinion in Lipidology
van Leuven, SI and Kastelein, JJP and Hayden, MR and d'Cruz, D and Hughes, GR and Stroes, ES
DOI: 10.1097/01.mol.0000182533.19135.cb
2005

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease
Journal of Neuroscience
Van Raamsdonk, JM and Pearson, J and Slow, EJ and Hossain, SM and Leavitt, BR and Hayden, MR
DOI: 10.1523/JNEUROSCI.0590-05.2005
2005

Complete functional rescue of the ABCA1(-/-) mouse by human BAC transgenesis
Journal of Lipid Research
Coutinho, JM and Singaraja, RR and Kang, M and Arenillas, DJ and Bertram, LN and Bissada, N and Staels, B and Fruchart, JC and Fievet, C and Joseph-George, AM and Wasserman, WW and Hayden, MR
DOI: 10.1194/jlr.M400506-JLR200
2005

Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation
Arteriosclerosis Thrombosis and Vascular Biology
Ross, CJD and Liu, GQ and Kuivenhoven, JA and Twisk, J and Rip, J and van Dop, W and Excoffon, KJDA and Lewis, SME and Kastelein, JJ and Hayden, MR
DOI: 10.1161/01.ATV.0000176971.27302.b0
2005

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood
Neurobiology of Disease
Devon, RS and Schwab, C and Topp, JD and Orban, PC and Yang, YZ and Pape, TD and Helm, JR and Davidson, TL and Rogers, DA and Gros-Louis, F and Rouleau, G and Horazdovsky, BF and Leavitt, BR and Hayden, MR
DOI: 10.1016/j.nbd.2004.10.002
2005

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease
Journal of Neurochemistry
Van Raamsdonk, JM and Pearson, J and Bailey, CDC and Rogers, DA and Johnson, GVW and Hayden, MR and Leavitt, BR
DOI: 10.1111/j.1471-4159.2005.03357.x
2005

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease
Proceedings of the National Academy of Sciences of the United States of America
Tang, TS and Slow, E and Lupu, V and Stavrovskaya, IG and Sugimori, M and Llinas, R and Kristal, BS and Hayden, MR and Bezprozvanny, I
DOI: 10.1073/pnas.0409402102
2005

Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease
Journal of Neurochemistry
Jenkins, B. G. and Andreassen, O. A. and Dedeoglu, A. and Leavitt, B. and Hayden, M. and Borchelt, D. and Ross, C. A. and Ferrante, R. J. and Beal, M. F.
DOI: 10.1111/j.1471-4159.2005.03411.x
2005

Essential role of ABCA1 in HDL catabolism in mice
Arteriosclerosis Thrombosis and Vascular Biology
Rinninger, F. and Brundert, M. and Merkel, M. and Heeren, J. and Hayden, M. and Singaraja, R.
2005

Ethyl-EPA in Huntington disease - A double-blind, randomized, placebo-controlled trial
Neurology
Puri, BK and Leavitt, BR and Hayden, MR and Ross, CA and Rosenblatt, A and Greenamyre, JT and Hersch, S and Vaddadi, KS and Sword, A and Horrobin, DF and Manku, M and Murck, H
DOI: 10.1212/01.wnl.0000169025.09670.6d
2005

Ethyl-EPA in Huntington's disease: A double blind, randomised, placebo controlled trial
Journal of Neurology Neurosurgery and Psychiatry
Murck, H and Manku, M and Puri, BK and Leavitt, BR and Hayden, MR and Ross, CA and Rosenblatt, A and Greenamyre, JT and Hersch, S and Vaddadi, KS
2005

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease
Experimental Neurology
Van Raamsdonk, JM and Pearson, J and Rogers, DA and Lu, G and Barakauskas, VE and Barr, AM and Honer, WG and Hayden, MR and Leavitt, BR
DOI: 10.1016/j.expneurol.2005.07.021
2005

From genes to therapies: AAV-mediated gene therapy for LPL deficiency
Circulation
Ross, CJ and Twisk, J and Rip, J and Nierman, MC and Dijkhuizen, P and Hermens, WT and Meulenberg, JM and Kastelein, JJ and Kuivenhoven, JA and Hayden, MR
2005

Gene therapy for lipoprotein lipase deficiency: Working toward clinical application
Human Gene Therapy
Rip, J and Nierman, MC and Sierts, JA and Petersen, W and Van Den Oever, K and Van Raalte, D and Ross, CJD and Hayden, MR and Bakker, AC and Dijkhuizen, P and Hermens, WT and Twisk, J and Stroes, E and Kastelein, JJP and Kuivenhoven, JA and Meulenberg, JM
DOI: 10.1089/hum.2005.16.1276
2005

Histone acetylation and recovery from excitotoxicity in striatal cells expressing full length mutant huntingtin
Journal of Neurology Neurosurgery and Psychiatry
Oliveira, JM and Chen, SF and Almeida, S and Riley, R and Goncalves, J and Oliveira, CR and Hayden, MR and Nicholls, DG and Ellerby, LM and Rego, AC
2005

HOXA7 protein expression in human normal ovary
Journal of the Society for Gynecologic Investigation
Ota, T. and Kwok, A. and Choi, K. B. and Pang, L. and Gilks, B. and Jefferies, W. A. and Hayden, M. R. and Leung, P. C. K. and Auersperg, N.
2005

Huntingtin associates with acidic phospholipids at the plasma membrane
Journal of Biological Chemistry
Kegel, KB and Sapp, E and Yoder, J and Cuiffo, B and Sobin, L and Kim, YJ and Qin, ZH and Hayden, MR and Aronin, N and Scott, DL and Isenberg, F and Goldmann, WH and DiFiglia, M
DOI: 10.1074/jbc.M503672200
2005

Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain
Journal of Biological Chemistry
Legendre-Guillemin, V and Metzler, M and Lemaire, JF and Philie, J and Gan, L and Hayden, MR and McPherson, PS
DOI: 10.1074/jbc.M408430200
2005

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo
Human Molecular Genetics
Warby, SC and Chan, EY and Metzler, M and Gan, L and Singaraja, RR and Crocker, SF and Robertson, HA and Hayden, MR
DOI: 10.1093/hmg/ddi165
2005

Huntington's disease: Lessons for ChAc
Movement Disorders
Hayden, MR
2005

Increased expression of ABCA1 provides significant protection against atherosclerosis
Circulation
Singaraja, RR and Fievet, C and Bissada, N and Kang, M and McManus, B and Staels, B and Hayden, MR
2005

Intestinal ABCA1 is a significant contributor to plasma HDL-C and apoB levels in vivo
Circulation
Brunham, L and Kruit, JK and Pape, TD and Havinga, R and Flevet, C and Timmins, JM and Bissada, N and Staels, B and Groen, AK and Parks, JS and Kuipers, F and Hayden, MR
2005

Introduction to social and behavioural research in genetics
Clinical Genetics
Hayden, MR
DOI: 10.1111/j.1399-0004.2005.00464.x
2005

Links between proteolysis and neurotoxicity identify novel approaches for modifying the pathogenesis of Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Graham, RK and Yanai, A and El Husseini, A and Hayden, MR
2005

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease
Human Molecular Genetics
Van Raamsdonk, JM and Pearson, J and Rogers, DA and Bissada, N and Vogl, AW and Hayden, MR and Leavitt, BR
DOI: 10.1093/hmg/ddi147
2005

MR spectroscopy shows metabolic changes in transgenic Huntington's disease mice
Nordic Journal of Psychiatry
Andreassen, OA and Jenkins, BG and Kuesterman, E and Dedeoglu, A and Hayden, MR and Ross, CA and Borchelt, DR and Beal, MF
2005

Selective degeneration and nuclear localisation of mutant huntingtin in the YAC128 mouse model of Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Van Raamsdonk, JM and Murphy, Z and Slow, EJ and Leavitt, BR and Hayden, MR
2005

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease
Human Molecular Genetics
Van Raamsdonk, JM and Murphy, Z and Slow, EJ and Leavitt, BR and Hayden, MR
DOI: 10.1093/hmg/ddi407
2005

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
Journal of Clinical Investigation
Timmins, JM and Lee, JY and Boudyguina, E and Kluckman, KD and Brunham, LR and Mulya, A and Gebre, AK and Coutinho, JM and Colvin, PL and Smith, TL and Hayden, MR and Maeda, N and Parks, JS
DOI: 10.1172/JCI200523915
2005

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
Journal of Biological Chemistry
Hirsch-Reinshagen, V and Maia, LF and Burgess, BL and Blain, JF and Naus, KE and McIsaac, SA and Parkinson, PF and Chan, JY and Tansley, GH and Hayden, MR and Poirier, J and Van Nostrand, W and Wellington, CL
DOI: 10.1074/jbc.M508781200
2005

Tissue specific deletion of enterocyte ABCA1 identifies the intestine as a significant source of plasma HDL cholesterol in vivo
Arteriosclerosis Thrombosis and Vascular Biology
Brunham, LR and Pape, TD and Flevet, C and Timmins, JM and Bissada, N and Coburn, BA and Staels, B and Parks, JS and Hayden, MR
2005

Transglutaminases in Huntington disease (HD)
Journal of Neurochemistry
Cooper, AJ and Krasnikov, BF and Pinto, JT and Van Raamsdonk, JM and Hayden, MR and Leavitt, BR and Jeitner, TM
2005

Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease
Journal of Neurochemistry
Pinto, JT and Van Raamsdonk, JM and Leavitt, BR and Hayden, MR and Jeitner, TM and Thaler, HT and Krasnikov, BF and Cooper, AJL
DOI: 10.1111/j.1471-4159.2005.03255.x
2005

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene
Plos Genetics
Brunham, LR and Singaraja, RR and Pape, TD and Kejariwal, A and Thomas, PD and Hayden, MR
DOI: 10.1371/journal.pgen.0010083
2005

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
Molecular and Cellular Biology
Trushina, E. and Dyer, R. B. and Badger, J. D. and Ure, D. and Eide, L. and Tran, D. D. and Vrieze, B. T. and Legendre-Guillemin, V. and McPherson, P. S. and Mandavilli, B. S. and Van Houten, B. and Zeitlin, S. and McNiven, M. and Aebersold, R. and Hayden, M. and Parisi, J. E. and Seeberg, E. and Dragatsis, I. and Doyle, K. and Bender, A. and Chacko, C. and McMurray, C. T.
DOI: 10.1128/mcb.24.18.8195-8209.2004
2004

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice
Experimental Neurology
Zala, D and Bensadoun, JC and de Almeida, LP and Leavitt, BR and Gutekunst, CA and Aebischer, P and Hayden, MR and Deglon, N
DOI: 10.1016/j.expneurol.2003.09.002
2004

Mutations in LCAT, ApoA-I, and ABCA1 can be distinguished by NMR lipoprotein subphenotyping
Arteriosclerosis Thrombosis and Vascular Biology
Brownlie, A and Hovingh, GK and Coutinho, J and Dube, MP and Klerkx, AH and Otvos, JD and Ludwig, EH and Kastelein, JJ and Hayden, MR and Kuivenhoven, JA
2004

Palmitoylation of ABCA1 is required for its normal trafficking to the plasma membrane and for lipid efflux activity
Circulation
Singaraja, RR and Kang, MH and Coutinho, JM and Arstikaitis, P and El Husseini, A and Hayden, MR
2004

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease
Molecular and Cellular Neuroscience
Zeron, MM and Fernandes, HB and Krebs, C and Shehadeh, J and Wellington, CL and Leavitt, BR and Baimbridge, KG and Hayden, MR and Raymond, LA
DOI: 10.1016/j.mcn.2003.11.014
2004

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
Cell Death and Differentiation
Hermel, E and Gafni, J and Propp, SS and Leavitt, BR and Wellington, CL and Young, JE and Hackam, AS and Logvinova, AV and Peel, AL and Chen, SF and Hook, V and Singaraja, R and Krajewski, S and Goldsmith, PC and Ellerby, HM and Hayden, MR and Bredesen, DE and Ellerby, LM
DOI: 10.1038/sj.cdd.4401358
2004

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility
Journal of Lipid Research
Selva, DM and Hirsch-Reinshagen, V and Burgess, B and Zhou, S and Chan, J and McIsaac, S and Hayden, MR and Hammond, GL and Vogl, AW and Wellington, CL
DOI: 10.1194/jlr.M400007-JLR200
2004

The contribution of hepatic adenosine triphosphate-binding cassette transporter, ABCA1, to high-density lipoprotein cholesterol levels in vivo.
Journal of Investigative Medicine
Brunham, LR and Wellington, CL and Orban, PC and Deng, Y and Hayden, MR
2004

The endocytic protein HIP1 influences NMDAR function
Molecular Biology of the Cell
Metzler, M and Gan, L and Wong, TP and Liu, L and Helm, J and Wang, YS and Wang, YT and Hayden, MR
2004

Tissue-specific hepatic deletion of ABCA1 indicates that the liver is the primary site of HDL formation in vivo
Arteriosclerosis Thrombosis and Vascular Biology
Timmins, JM and Lee, JY and Mulya, A and Kluckman, K and Brunham, LR and Hayden, MR and Maeda, N and Parks, JS
2004

Huntington's disease-like 2 (HFL2) in North America and Japan (vol 56, pg 670, 2004)
Annals of Neurology
Margolis, R. L. and Holmes, S. E. and Rosenblatt, A. and Gourley, L. and O'Hearn, E. and Ross, C. A. and Seltzer, W. K. and Walker, R. H. and Ashizawa, T. and Rasmussen, A. and Hayden, M. and Almqvist, E. W. and Harris, J. and Fahn, S. and MacDonald, M. E. and Mysore, J. and Shimohata, T. and Tsuji, S. and Potter, N. and Nakaso, K. and Adachi, Y. and Nakashima, K. and Bird, T. and Krause, A. and Greenstein, P.
DOI: 10.1002/ana.20349
2004

A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis
Clinical Genetics
Delatycki, MB and Allen, KJ and Gow, P and MacFarlane, J and Radomski, C and Thompson, J and Hayden, MR and Goldberg, YP and Samuels, ME
DOI: 10.1111/j.0009-9163.2004.00254.x
2004

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length
Clinical Genetics
Langbehn, DR and Brinkman, RR and Falush, D and Paulsen, JS and Hayden, MR and Int Huntingtons Dis Collaborative
DOI: 10.1111/j.1399-0004.2004.00241.x
2004

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length (vol 65, pg 267, 2004)
Clinical Genetics
Langbehn, DR and Brinkman, RR and Falush, D and Paulsen, JS and Hayden, MR and Int Huntingtons Dis Collaborative
DOI: 10.1111/j.1399-0004.2004.00299.x
2004

A novel ApoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease
Journal of the American College of Cardiology
Hovingh, GK and Brownlie, A and Bisoendial, RJ and Dube, MP and Levels, JHM and Petersen, W and Dullaart, RPF and Stroes, ESG and Zwinderman, AH and de Groot, E and Hayden, MR and Kuivenhoven, JA and Kastelein, JJP
DOI: 10.1016/j.jacc.2004.06.070
2004

ABCA1 modulates APOE levels in brain and plasma
Neurobiology of Aging
Hirsch-Reinshagen, V. and Zhou, S. and Chan, J. and McIsaac, S. and Cohn, J. and Hayden, M. and Wellington, C.
DOI: 10.1016/s0197-4580(04)80050-2
2004

ABCA1-mediated lipid transport from both the liver and the periphery are essential for maintenance of plasma HDL levels in vivo
Circulation
Singaraja, RR and Coutinho, JM and Ross, C and Bissada, N and Kang, MH and Brunham, LR and Timmins, JM and Miao, F and Parks, JS and Hayden, MR
2004

Clinical and radiographic features among presymptomatic individuals carrying an expanded CAG repeat in the Huntington's disease gene: Analysis of baseline characteristics of the PREDICT-HD cohort
Neurology
Ross, C. A. and Aylward, E. H. and Stout, J. C. and Biglan, K. M. and Hayden, M. R. and Shoulson, I. and Langbehn, D. R. and Paulsen, J. S. and Predict, H. D. Investigators H. S. D.
2004

Correction of dyslipidemia in murine and feline models of lipoprotein lipase deficiency by intramuscular administration of AAV1-LPLS447X
Molecular Therapy
Ross, CJD and Twisk, J and Kuivenhoven, JA and Liu, GQ and Miao, FD and van den Oever, K and Beetz, M and Verbart, D and Bakker, A and Oranje, PPA and Hermens, WT and Dijkhuizen, P and Kastelein, JJP and Meulenberg, JJM and Hayden, MR
2004

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
Journal of Biological Chemistry
Hirsch-Reinshagen, V and Zhou, S and Burgess, BL and Bernier, L and McIsaac, SA and Chan, JY and Tansley, GH and Cohn, JS and Hayden, MR and Wellington, CL
DOI: 10.1074/jbc.M407962200
2004

Deranged neuronal calcium signaling and Huntington disease
Biochemical and Biophysical Research Communications
Bezprozvanny, I and Hayden, MR
DOI: 10.1016/j.bbrc.2004.08.035
2004

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
Nature
Saleh, M and Vaillancourt, JP and Graham, RK and Huyck, M and Srinivasula, SM and Alnemri, ES and Steinberg, MH and Nolan, V and Baldwin, CT and Hotchkiss, RS and Buchman, TG and Zehnbauer, BA and Hayden, MR and Farrer, LA and Roy, S and Nicholson, DW
DOI: 10.1038/nature02451
2004

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease
Journal of Neurophysiology
Li, LJ and Murphy, TH and Hayden, MR and Raymond, LA
DOI: 10.1152/jn.00308.2004
2004

Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16
Neurogenetics
Djousse, L and Knowlton, B and Hayden, MR and Almqvist, EW and Brinkman, RR and Ross, CA and Margolis, RL and Rosenblatt, A and Durr, A and Dode, C and Morrison, PJ and Novelletto, A and Frontali, M and Trent, RJA and McCusker, E and Gomez-Tortosa, E and Cabrero, DM and Jones, R and Zanko, A and Nance, M and Abramson, RK and Suchowersky, O and Paulsen, JS and Harrison, MB and Yang, Q and Cupples, LA and Mysore, J and Gusella, JF and MacDonald, ME and Myers, RH
DOI: 10.1007/s10048-004-0175-2
2004

Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: A marker of cardiac dilatation
Molecular and Cellular Biochemistry
Reddy, HK and Tjahja, IE and Campbell, SE and Janicki, JS and Hayden, MR and Tyagi, SC
DOI: 10.1023/B:MCBI.0000044387.04670.81
2004

Genetic testing and Huntington's disease: issues of employment
Lancet Neurology
Harper, PS and Gevers, S and de Wert, G and Creighton, S and Bombard, Y and Hayden, MR
DOI: 10.1016/S1474-4422(04)00711-2
2004

HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca2+ release in primary culture of striatal medium spiny neurons
European Journal of Neuroscience
Tang, TS and Tu, HP and Orban, PC and Chan, EYW and Hayden, MR and Bezprozvanny, I
DOI: 10.1111/j.1460-9568.2004.03633.x
2004

HDL deficiency and atherosclerosis: lessons from Tangier disease
Journal of Internal Medicine
Hovingh, GK and Kuivenhoven, JA and Bisoendial, RJ and Groen, AK and Dam, M and Tol, A and Wellington, C and Hayden, MR and Smelt, AHM and Kastelein, JJP
DOI: 10.1046/j.0954-6820.2003.01256.x
2004

Humanized transgenic ABCA1 mice show complete functional rescue of mouse ABCA1 deficiency
Arteriosclerosis Thrombosis and Vascular Biology
Coutinho, J and Singaraja, R and Kang, M and Fievet, C and Hayden, MR
2004

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
Journal of Neuroscience
Qin, ZH and Wang, YM and Sapp, E and Cuiffo, B and Wanker, E and Hayden, MR and Kegel, KB and Aronin, N and DiFiglia, M
DOI: 10.1523/JNEUROSCI.1409-03.2004
2004

Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins
Neuron
Huang, K and Yanai, A and Kang, R and Arstikaitis, P and Singaraja, RR and Metzler, M and Mullard, A and Haigh, B and Gauthier-Campbell, C and Gutekunst, CA and Hayden, MR and El-Husseini, A
DOI: 10.1016/j.neuron.2004.11.027
2004

Huntington's disease-like 2 (HDL2) in North America and Japan
Annals of Neurology
Margolis, R. L. and Holmes, S. E. and Rosenblatt, A. and Gourley, L. and O'Hearn, E. and Ross, C. A. and Seltzer, W. K. and Walker, R. H. and Ashizawa, T. and Rasmussen, A. and Hayden, M. and Almqvist, E. W. and Harris, J. and Fahn, S. and MacDonald, M. E. and Mysore, J. and Shimohata, T. and Tsuji, S. and Potter, N. and Nakaso, K. and Adachi, Y. and Nakashima, K. and Bird, T. and Krause, A. and Greenstein, P.
DOI: 10.1002/ana.20248
2004

Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the study of Canadian genetic isolates
American Journal of Human Genetics
Lafreniere, RG and MacDonald, MLE and Dube, MP and MacFarlane, J and O'Driscoll, M and Brais, B and Meilleur, S and Brinkman, RR and Dadivas, O and Pape, T and Platon, C and Radomski, C and Risler, J and Thompson, J and Guerra-Escobio, AM and Davar, G and Breakefield, XO and Pimstone, SN and Green, R and Pryse-Phillips, W and Goldberg, YP and Younghusband, HB and Hayden, MR and Sherrington, R and Rouleau, GA and Samuels, ME
DOI: 10.1086/420795
2004

Inhibition of calpain cleavage of huntingtin reduces toxicity - Accumulation of calpain/caspase fragments in the nucleus
Journal of Biological Chemistry
Gafni, J and Hermel, E and Young, JE and Wellington, CL and Hayden, MR and Ellerby, LM
DOI: 10.1074/jbc.M401267200
2004

Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPLS447X beneficial mutation
Human Gene Therapy
Ross, CJD and Twisk, J and Meulenberg, JM and Liu, GQ and van den Oever, K and Moraal, E and Hermens, WT and Rip, J and Kastelein, JJP and Kuivenhoven, JA and Hayden, MR
DOI: 10.1089/1043034041839235
2004

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
Nature Genetics
Papanikolaou, G and Samuels, ME and Ludwig, EH and MacDonald, MLE and Franchini, PL and Dube, MP and Andres, L and MacFarlane, J and Sakellaropoulos, N and Politou, M and Nemeth, E and Thompson, J and Risler, JK and Zaborowska, C and Babakaiff, R and Radomski, CC and Pape, TD and Davidas, O and Christakis, J and Brissot, P and Lockitch, G and Ganz, T and Hayden, MR and Goldberg, YP
DOI: 10.1038/ng1274
2004

A genetic, biochemical and proteomic approach to dissection of inherited HDL phenotypes in humans
Atherosclerosis Supplements
Brownlie, A. and Ludwig, E. and Hovingh, K. and Van Wijland, M. and Bisoendial, R. and Klerkx, A. and Dube, M. P. and Samuels, M. and Groen, A. and Kastelein, J. and Hayden, M.
DOI: 10.1016/s1567-5688(03)90594-0
2003

A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study
American Journal of Human Genetics
Li, JL and Hayden, MR and Almqvist, EW and Brinkman, RR and Durr, A and Dode, C and Morrison, PJ and Suchowersky, O and Ross, CA and Margolis, RL and Rosenblatt, A and Gomez-Tortosa, E and Cabrero, DM and Novelletto, A and Frontali, M and Nance, M and Trent, RJA and McCusker, E and Jones, R and Paulsen, JS and Harrison, M and Zanko, A and Abramson, RK and Russ, AL and Knowlton, B and Djousse, L and Mysore, JS and Tariot, S and Gusella, MF and Wheeler, VC and Atwood, LD and Cupples, LA and Saint-Hilaire, M and Cha, JHJ and Hersch, SM and Koroshetz, WJ and Gusella, JF and MacDonald, ME and Myers, RH
DOI: 10.1086/378133
2003

A genome scan for modifiers of age at onset in Huntington's disease: The HD MAPS study
American Journal of Human Genetics
Li, J. L. and Hayden, M. and Almqvist, E. W. and Durr, A. and Dod, C. and Morrison, P. J. and Suchowersky, O. and Ross, C. A. and Margolis, R. L. and Gmez-Tortosa, E. and Mayo, D. and Novelletto, A. and Nance, M. and Trent, R. J. A. and Zanko, A. and Abramson, R. K. and Russ, A. L. and Gusella, J. F. and MacDonald, M. E. and Myers, R. H.
2003

A novel apoA-I mutation (Leu178Pro), identified by whole genome linkage approach, predisposes to endothelial dysfunction, increased arterial wall thickness and premature coronary artery disease
Atherosclerosis Supplements
Hovingh, GK and Bisoendial, RJ and Brownlie, A and Samuels, M and Kuivenhoven, JA and De Groot, E and Stroes, ESG and Hayden, MR and Kastelein, JJP
DOI: 10.1016/S1567-5688(03)90113-9
2003

A novel apoAl mutation (Leu178Pro) leads to severely disturbed HDL metabolism, endothelial dysfunction, increased arterial wall thickness and premature coronary artery disease
Circulation
Hovingh, G. K. and Brownlie, A. and Bisoendial, R. J. and Kuivenhoven, J. A. and Levels, J. H. and Dube, M. and Stroes, E. S. and de Groot, E. and Hayden, M. R. and Kastelein, J. J.
2003

A novel CETP mutation (IVS7+1) in a family of Dutch descent with hyperalphalipoproteinemia
Circulation
Klerkx, AH and Hovingh, GK and Nootenboom, IC and Brownlie, AJ and van Tol, A and Hayden, MR and Kastelein, JJ and Kuivenhoven, JA
2003

A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding
Journal of Biological Chemistry
Hussain, NK and Yamabhai, M and Bhakar, AL and Metzler, M and Ferguson, SSG and Hayden, MR and McPherson, PS and Kay, BK
DOI: 10.1074/jbc.M300995200
2003

ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens
Journal of Biological Chemistry
Mulligan, JD and Flowers, MT and Tebon, A and Bitgood, JJ and Wellington, C and Hayden, MR and Attie, AD
DOI: 10.1074/jbc.M212377200
2003

Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element
Molecular and Cellular Probes
Hoogendijk, CF and Scholtz, CL and Pimstone, SM and Ehrenborg, E and Kastelein, JJP and Defesche, JC and Thiart, R and du Plessis, L and de Villiers, JNP and Zaahl, MG and Delport, R and Rubinsztein, DC and Raffel, LJ and Grim, CE and Mediene-Benchekor, S and Amouyel, P and Brousseau, T and Steyn, K and Lombard, CJ and Hayden, MR and Kotze, MJ
DOI: 10.1016/S0890-8508(03)00050-1
2003

Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1
Journal of Lipid Research
Wellington, CL and Brunham, LR and Zhou, S and Singaraja, RR and Visscher, H and Gelfer, A and Ross, C and James, E and Liu, GQ and Huber, MT and Yang, YZ and Parks, RJ and Groen, A and Fruchart-Najib, J and Hayden, MR
DOI: 10.1194/jlr.M300110-JLR200
2003

An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred
Annals of Neurology
Gros-Louis, F and Meijer, IA and Hand, CK and Dube, MP and MacGregor, DL and Seni, MH and Devon, RS and Hayden, MR and Andermann, F and Andermann, E and Rouleau, GA
DOI: 10.1002/ana.10422
2003

Biochemical characterization of mutations in ABCA1 correlate with disease severity
Atherosclerosis Supplements
Singaraja, R. and Visscher, H. and James, E. and Hayden, M.
DOI: 10.1016/s1567-5688(03)90587-3
2003

Caudate volume as an outcome measure in clinical trials for Huntington's disease: a pilot study
Brain Research Bulletin
Aylward, E. H. and Rosenblatt, A. and Field, K. and Yallapragada, V. and Kieburtz, K. and McDermott, M. and Raymond, L. A. and Almqvist, E. W. and Hayden, M. and Ross, C. A.
DOI: 10.1016/j.brainresbull.2003.09.005
2003

Clarity is essential when using nucleotide number systems
Atherosclerosis
Brunham, LR and Hayden, MR
DOI: 10.1016/S0021-9150(03)00234-X
2003

Depletion of wild-type huntingtin in mouse models of neurologic diseases
Journal of Neurochemistry
Zhang, YU and Li, MW and Drozda, M and Chen, MH and Ren, SJ and Sanchez, ROM and Leavitt, BR and Cattaneo, E and Ferrante, RJ and Hayden, MR and Friedlander, RM
DOI: 10.1046/j.1471-4159.2003.01980.x
2003

Disruption of the endocytic protein HIP1 results in major neurological deficits and decreased AMPA receptor trafficking
American Journal of Human Genetics
Metzler, MM and Gan, L and Li, B and Georgiou, J and Gutekunst, CA and Wang, Y and Torre, E and Wang, YT and Roder, JC and Raymond, LA and Hayden, MR
2003

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking
Embo Journal
Metzler, M and Li, B and Gan, L and Georgiou, J and Gutekunst, CA and Wang, YS and Torre, E and Devon, RS and Oh, R and Legendre-Guillemin, V and Rich, M and Alvarez, C and Gertsenstein, M and McPherson, PS and Nagy, A and Wang, YT and Roder, JC and Raymond, LA and Hayden, MR
DOI: 10.1093/emboj/cdg334
2003

Distinct cellular and biochemical effects of specific mutations in ABCA1 predicts the phenotype in TD and FHA
American Journal of Human Genetics
Singaraja, R. and Visscher, H. and James, E. and Hayden, M.
2003

Dosage effects of riluzole in Huntington's disease - A multicenter placebo-controlled study
Neurology
Marshall, F. J. and Cudkowicz, M. and Hayden, M. and Kieburtz, K. and Zhao, H. W. and Penney, J. and Dure, L. and Lane, J. and Raymond, L. and Decolongon, J. and Marder, K. and Moskowitz, C. and Dubinsky, R. and Gray, C. and Nance, M. and Radtke, D. and Feigin, A. and Shannon, B. and Higgins, D. and Baic, C. and Shannon, K. and Jaglin, J. and Hauser, R. and Delgado, H. and Almqvist, E. W. and de Blieck, E. A. and Biglan, K. and Hogarth, P. and Brocht, A. and Chadwick, C. and Daigneault, S. and Donaghue, P. and Josephson, L. and Shinaman, A. and Slough, M. and Weaver, C. and Bourgeois, K. and Oakes, D. and Watts, A. and Huntington Study, Grp
2003

Efflux and atherosclerosis - The clinical and biochemical impact of variations in the ABCA1 gene
Arteriosclerosis Thrombosis and Vascular Biology
Singaraja, RR and Brunham, LR and Visscher, H and Kastelein, JJP and Hayden, MR
DOI: 10.1161/01.ATV.0000078520.89539.77
2003

Functional analysis of mutations in the ABCA1 gene
Journal of Investigative Medicine
Brunham, L. and Singaraja, R. and Visscher, H. and James, E. and Hayden, M.
2003

Functional effects of tissue-specific expression of ATP-cassette transporter A1 (ABCA1) provide multiple mechanisms for protection against atherosclerosis
Atherosclerosis Supplements
Hayden, M. and Singaraja, R. and Van Eck, M. and Van Berkel, T. and Kastelein, J. J. P.
DOI: 10.1016/s1567-5688(03)91163-9
2003

Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size
Atherosclerosis
Kuivenhoven, JA and Hovingh, GK and van Tol, A and Jauhiainen, M and Ehnholm, C and Fruchart, JC and Brinton, EA and Otvos, JD and Smelt, AHM and Brownlee, A and Zwinderman, AH and Hayden, MR and Kastelein, JJP
DOI: 10.1016/j.atherosclerosis.2003.08.014
2003

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course
Brain
Squitieri, F and Gellera, C and Cannella, M and Mariotti, C and Cislaghi, G and Rubinsztein, DC and Almqvist, EW and Turner, D and Bachoud-Levi, AC and Simpson, SA and Delatycki, M and Maglione, V and Hayden, MR and Di Donato, S
DOI: 10.1093/brain/awg077
2003

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
American Journal of Human Genetics
Chan, E. Y. and Tang, T. and Tu, H. and Maximov, A. and Wang, Z. and Wellington, C. L. and Hayden, M. R. and Bezprozvanny, I.
2003

Huntingtin and Huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
Neuron
Tang, TS and Tu, HP and Chan, EYW and Maximov, A and Wang, ZN and Wellington, CL and Hayden, MR and Bezprozvanny, I
DOI: 10.1016/S0896-6273(03)00366-0
2003

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Nature Genetics
Zuccato, C and Tartari, M and Crotti, A and Goffredo, D and Valenza, M and Conti, L and Cataudella, T and Leavitt, BR and Hayden, MR and Timmusk, T and Rigamonti, D and Cattaneo, E
DOI: 10.1038/ng1219
2003

Huntingtin proteolysis in Huntington disease
Clinical Neuroscience Research
Wellington, CL and Ellerby, LM and Leavitt, BR and Roy, S and Nicholson, DW and Hayden, MR
DOI: 10.1016/S1566-2772(03)00055-0
2003

Huntington's disease - Preface
Clinical Neuroscience Research
Wellington, CL and Hayden, MR
DOI: 10.1016/S1566-2772(03)00053-7
2003

Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease
American Journal of Medical Genetics Part A
Djousse, L. and Knowlton, B. and Hayden, M. and Almqvist, E. W. and Brinkman, R. and Ross, C. and Margolis, R. and Rosenblatt, A. and Durr, A. and Dode, C. and Morrison, P. J. and Novelletto, A. and Frontali, M. and Trent, R. J. A. and McCusker, E. and Gomez-Tortosa, E. and Mayo, D. and Jones, R. and Zanko, A. and Nance, M. and Abramson, R. and Suchowersky, O. and Paulsen, J. and Harrison, M. and Yang, Q. and Cupples, L. A. and Gusella, J. F. and MacDonald, M. E. and Myers, R. H.
DOI: 10.1002/ajmg.a.20190
2003

Long-term correction of murine lipoprotein lipase (LPL) deficiency by a single intramuscular administration of AAV1-LPLS447X
Circulation
Ross, CJ and Twisk, J and Kuivenhoven, JA and Liu, GQG and Miao, F and Scheenhart-van der Meer, JW and Bakker, A and Moraal, E and Oranje, PP and Hermens, WT and Kastelein, JJ and Meulenberg, JJ and Hayden, MR
2003

Long-term correction of murine lipoprotein lipase deficiency by single intramuscular administration of AAV1-LPLS447X
Molecular Therapy
Ross, CJD and Meulenberg, JJM and Twisk, J and Kuivenhoven, JA and Liu, GQG and Miao, FD and Moraal, E and Oranje, PPA and Bakker, A and Hermens, WTJMC and Scheenhart-van der Meer, JJW and Kastelein, JJP and Hayden, MR
2003

Macrophage ABCA1 overexpression inhibits atherosclerotic lesion progression
Atherosclerosis Supplements
Van Eck, M and Singaraja, RR and Hildebrand, RB and James, ER and Hayden, MR and Van Berkel, TJC
DOI: 10.1016/S1567-5688(03)90585-X
2003

Macrophage-specific ATP-Binding cassette transporter 1 (ABCA1) overexpression inhibits atherosclerotic lesion progression
Circulation
Van Eck, M and Singaraja, RR and Hildebrand, RB and James, ER and Hayden, MR and Van Berkel, TJ
2003

Mutant frizzled-4 (FZD4) causes autosomal dominant familial exudative vitreoretinopathy (FEVR) with variable intrafamilial phenotype
Investigative Ophthalmology & Visual Science
Robitaille, JM and MacDonald, MLE and Guernsey, DL and Zheng, B and Siebert, LS and Hoskin-Mott, A and Beis, MJ and Hayden, MR and Goldberg, YP and Samuels, ME
2003

Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis
Archives of Neurology
Hand, CK and Devon, RS and Gros-Louis, F and Rochefort, D and Khoris, J and Meininger, V and Bouchard, JP and Camu, W and Hayden, MR and Rouleau, GA
DOI: 10.1001/archneur.60.12.1768
2003

Mutations in a novel gene cause hereditary sensory and autonomic neuropathy type II
American Journal of Human Genetics
Samuels, M. and Lafreniere, R. and MacDonald, M. and MacFarlane, J. and Dube, M. P. and O'Driscoll, M. and Meilleur, S. and Thompson, J. and Goldberg, Y. P. and Brais, B. and Pryse-Phillips, W. and Green, R. and Younghusband, B. and Hayden, M. and Sherrington, R. and Rouleau, G.
2003

Mutations in the HFE2A gene cause juvenile hemochromatosis
American Journal of Human Genetics
Goldberg, P. and Papanikolaou, G. and Ludwig, E. and MacDonald, M. and Andres, L. and Dube, M. P. and Franchini, P. and Babakaiff, R. and Risler, J. and Zaborowska, C. and Pimstone, S. and Brissot, P. and Lockitch, G. and Hayden, M. and Samuels, M.
2003

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity
Journal of Biological Chemistry
Nucifora, FC and Ellerby, LM and Wellington, CL and Wood, JD and Herring, WJ and Sawa, A and Hayden, MR and Dawson, VL and Dawson, TM and Ross, CA
DOI: 10.1074/jbc.M211224200
2003

Predictive testing for Huntington's disease: a universal model?
Lancet Neurology
Hayden, MR
DOI: 10.1016/S1474-4422(03)00317-X
2003

Predictive testing for persons at risk for homozygosity for CAG expansion in the Huntington disease gene
Clinical Genetics
Squitieri, F and Almqvist, EW and Cannella, M and Cislaghi, G and Hayden, MR
DOI: 10.1046/j.1399-0004.2003.00155.x
2003

Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000
Clinical Genetics
Creighton, S and Almqvist, EW and MacGregor, D and Fernandez, B and Hogg, H and Beis, J and Welch, JP and Riddell, C and Lokkesmoe, R and Khalifa, M and MacKenzie, J and Sajoo, A and Farrell, S and Robert, F and Shugar, A and Summers, A and Meschino, W and Allingham-Hawkins, D and Chiu, T and Hunter, A and Allanson, J and Hare, H and Schween, J and Collins, L and Sanders, S and Greenberg, C and Cardwell, S and Lemire, E and MacLeod, P and Hayden, MR
DOI: 10.1034/j.1399-0004.2003.00093.x
2003

Pro-survival effects of wild-type huntingtin in vivo.
American Journal of Human Genetics
Leavitt, BR and Rogers, D and van-Raamsdonk, J and Opina, CJ and Chan, E and Wellington, CL and Hayden, MR
2003

Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease
Clinical Genetics
Almqvist, EW and Brinkman, RR and Wiggins, S and Hayden, MR and Canadian Collaborative Study Predi
DOI: 10.1034/j.1399-0004.2003.00157.x
2003

Restoration of endothelial function by increasing HDL in subjects with isolated low-HDL
Atherosclerosis Supplements
Bisoendial, RJ and Hovingh, GK and Levels, JHM and Lerch, PG and Andresen, I and Hayden, MR and Kastelein, JJP and Stroes, ESG
DOI: 10.1016/S1567-5688(03)91303-1
2003

Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein
Circulation
Bisoendial, RJ and Hovingh, GK and Levels, JHM and Lerch, PG and Andresen, I and Hayden, MR and Kastelein, JJP and Stroes, ESG
DOI: 10.1161/01.CIR.0000070934.69310.1A
2003

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease
Neurobiology of Aging
Li, LJ and Fan, M and Icton, CD and Chen, NS and Leavitt, BR and Hayden, MR and Murphy, TH and Raymond, LA
DOI: 10.1016/j.neurobiolaging.2003.04.003
2003

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
Human Molecular Genetics
Slow, EJ and van Raamsdonk, J and Rogers, D and Coleman, SH and Graham, RK and Deng, Y and Oh, R and Bissada, N and Hossain, SM and Yang, YZ and Li, XJ and Simpson, EM and Gutekunst, CA and Leavitt, BR and Hayden, MR
DOI: 10.1093/hmg/ddg169
2003

The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings
Clinical Genetics
Devon, RS and Helm, JR and Rouleau, GA and Leitner, Y and Lerman-Sagie, T and Lev, D and Hayden, MR
DOI: 10.1034/j.1399-0004.2003.00138.x
2003

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia
Journal of Lipid Research
Hovingh, GK and van Wijland, MJA and Brownlie, A and Bisoendial, RJ and Hayden, MR and Kastelein, JJP and Groen, AK
DOI: 10.1194/jlr.M300080-JLR200
2003

Working towards clinical application of gene therapy for LPL deficiency
Circulation
Rip, J and Nierman, MC and Sierts, JA and van Raalte, D and Petersen, W and van den Oever, K and Ross, CJ and Hayden, MR and Meulenberg, JM and Twisk, J and Kastelein, JJ and Kuivenhoven, JA
2003

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol
Journal of Lipid Research
Wellington, CL and Yang, YZ and Zhou, S and Clee, SM and Tan, B and Hirano, K and Zwarts, K and Kwok, A and Gelfer, A and Marcil, M and Newman, S and Roomp, K and Singaraja, R and Collins, J and Zhang, LH and Groen, AK and Hovingh, K and Brownlie, A and Tafuri, S and Genest, J and Kastelein, JJP and Hayden, MR
DOI: 10.1194/jlr.M200277-JLR200
2002

A whole genome linkage approach identifies a novel ApoA1 mutation causing five percent of familial hypoalphalipoproteinemia in the Dutch population.
American Journal of Human Genetics
Samuels, M and Hovingh, GK and Kuivenhoven, JA and Dube, MP and Verschoof, H and Goldberg, YP and Kastelein, JJP and Hayden, MR and Brownlie, A
2002

Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene
Journal of Lipid Research
Peterson, J and Ayyobi, AF and Ma, YH and Henderson, H and Reina, M and Deeb, SS and Santamarina-Fojo, S and Hayden, MR and Brunzell, AD
2002

Striatal neurochemical changes in transgenic models of Huntington's disease
Journal of Neuroscience Research
Ariano, MA and Aronin, N and Difiglia, M and Tagle, DA and Sibley, DR and Leavitt, BR and Hayden, MR and Levine, MS
DOI: 10.1002/jnr.10272
2002

Skewed XCl in women experiencing a pregnancy with meiotic nondisjunction.
American Journal of Human Genetics
Penaherrera, MS and Beever, CL and Jiang, RH and McFadden, DE and Hayden, MR and Field, LL and Kalousek, DK and Brown, CJ and Robinson, WP
2002

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
Journal of Lipid Research
Attie, AD and Krauss, RM and Gray-Keller, MP and Brownlie, A and Miyazaki, M and Kastelein, JJ and Lusis, AJ and Stalenhoef, AFH and Stoehr, JP and Hayden, MR and Ntambi, JM
DOI: 10.1194/jlr.M200189-JLR200
2002

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partners Hippi
Nature Cell Biology
Gervais, FG and Singaraja, R and Xanthoudakis, S and Gutekunst, CA and Leavitt, BR and Metzler, M and Hackam, AS and Tam, J and Vaillancourt, JP and Houtzager, V and Rasper, DM and Roy, S and Hayden, MR and Nicholson, DW
DOI: 10.1038/ncb735
2002

Proteomics of clathrin-coated vesicles: Identification of novel endocytic proteins
Faseb Journal
McPherson, PS and Legendre-Guillemin, V and Metzler, M and Hayden, MR and Bell, AW and Wasiak, S
2002

Protein kinase a site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux
Journal of Biological Chemistry
See, RH and Caday-Malcolm, RA and Singaraja, RR and Zhou, S and Silverston, A and Huber, MT and Moran, J and James, ER and Janoo, R and Savill, JM and Rigot, V and Zhang, LH and Wang, MH and Chimini, G and Wellington, CL and Tafuri, SR and Hayden, MR
DOI: 10.1074/jbc.M204923200
2002

PKA site-specific phosphorylation of ABCA1 regulates ApoA-1-dependent phospholipid efflux
Circulation
See, RH and Caday-Malcolm, RA and Singaraja, RR and Zhou, S and Silverston, A and Huber, MT and Moran, J and James, ER and Janoo, R and Zhang, LH and Wang, MH and Wellington, CL and Tafuri, SR and Hayden, MR
2002

Phenotypic description of hereditary sensory neuropathy type 1A (HSN 1A) in two kindreds segregating the same mutation in the gene encoding serine palmitoyl transferase long chain subunit
American Journal of Human Genetics
O'Driscoll, MP and Ainsworth, P and Bieger, D and Goldberg, YP and Green, RC and Hahn, AF and Khani-Hanjani, A and Hayden, MR and MacFarlanes, J and Pryse-Phillips, W and Samuels, M and Younghusband, HB
2002

Nuclear localization of a truncation product of mutant atrophin-1, increases cellular toxicity
Molecular Biology of the Cell
Nucifora, FC and Wood, JD and Ellerby, LM and Herring, WJ and Sawa, A and Wellington, CL and Hayden, MR and Dawson, VL and Dawson, TM and Ross, CA
2002

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
Nature Genetics
Robitaille, J and MacDonald, MLE and Kaykas, A and Sheldahl, LC and Zeisler, J and Dube, MP and Zhang, LH and Singaraja, RR and Guernsey, DL and Zheng, BY and Siebert, LF and Hoskin-Mott, A and Trese, MT and Pimstone, SN and Shastry, BS and Moon, RT and Hayden, MR and Goldberg, YP and Samuels, ME
DOI: 10.1038/ng957
2002

Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract
Nature Genetics
Bu, L and Jin, YP and Shi, YF and Chu, RY and Ban, AR and Eiberg, H and Andres, L and Jiang, HS and Zheng, GY and Qian, MQ and Cui, B and Xia, Y and Liu, J and Hu, LD and Zhao, GP and Hayden, MR and Kong, XY
DOI: 10.1038/ng921
2002

Long-term efficacy of a single administration of AAV lipoprotein lipase gene therapy corrects murine hypertriglyceridemia and raises HDL
Circulation
Ross, CJD and Kuivenhoven, JA and Liu, GQG and Miao, F and Scheenhart-van der Meer, JWC and Moraal, E and Oranje, PPA and Hermens, WTJMC and Kastelein, JJP and Hayden, MR and Meulenberg, JJM
2002

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
Neuron
Zeron, MM and Hansson, O and Chen, NS and Wellington, CL and Leavitt, BR and Brundin, P and Hayden, MR and Raymond, LA
DOI: 10.1016/S0896-6273(02)00615-3
2002

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease
Human Molecular Genetics
Chan, EYW and Luthi-Carter, R and Strand, A and Solano, SM and Hanson, SA and DeJohn, MM and Kooperberg, C and Chase, KO and DiFiglia, M and Young, AB and Leavitt, BR and Cha, JHJ and Aronin, N and Hayden, MR and Olson, JM
DOI: 10.1093/hmg/11.17.1939
2002

Increased HDL and changes in lipoprotein composition are associated with increased efflux and atheroprotection in an ABCA1 BAC transgenic mouse model
Circulation
Singaraja, RR and Fievet, C and Castro, G and James, E and Clee, S and Hennuyer, N and Choy, J and Bissada, N and McManus, B and Staels, B and Hayden, MR
2002

Increased ABCA1 activity protects against atherosclerosis
Journal of Clinical Investigation
Singaraja, RR and Fievet, C and Castro, G and James, ER and Hennuyer, N and Clee, SM and Bissada, N and Choy, JC and Fruchart, JC and McManus, BM and Staels, B and Hayden, MR
DOI: 10.1172/JCI200215748
2002

Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken
Journal of Lipid Research
Attie, AD and Hamon, Y and Brooks-Wilson, AR and Gray-Keller, MP and MacDonald, MLE and Rigot, V and Tebon, A and Zhang, LH and Mulligan, JD and Singaraja, RR and Bitgood, JJ and Cook, ME and Kastelein, JJP and Chimini, G and Hayden, MR
DOI: 10.1194/jlr.M200223-JLR200
2002

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis
Human Molecular Genetics
Singaraja, RR and Hadano, S and Metzler, M and Givan, S and Wellington, CL and Warby, S and Yanai, A and Gutekunst, CA and Leavitt, BR and Yi, H and Fichter, K and Gan, L and McCutcheon, K and Chopra, V and Michel, J and Hersch, SM and Ikeda, JE and Hayden, MR
DOI: 10.1093/hmg/11.23.2815
2002

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin - Identification of a novel interaction with clathrin light chain
Journal of Biological Chemistry
Legendre-Guillemin, V and Metzler, M and Charbonneau, M and Gan, L and Chopra, V and Philie, J and Hayden, MR and McPherson, PS
DOI: 10.1074/jbc.M112310200
2002

Frizzled-4 mutations disrupt retinal angiogenesis in familial exudative vitreoretinopathy (FEVR)
American Journal of Human Genetics
MacDonald, MLE and Robitaille, J and Kaykas, A and Sheldahl, L and Dube, MP and Guernsey, D and Zheng, B and Siebert, L and Hoskin-Mott, A and Pimstone, SN and Shastry, BS and Moon, RT and Hayden, MR and Goldberg, YP and Samuels, ME
2002

Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency
Biochemical and Biophysical Research Communications
Nishida, Y and Hirano, K and Tsukamoto, K and Nagano, M and Ikegami, C and Roomp, K and Ishihara, M and Sakane, N and Zhang, ZY and Tsujii, K and Matsuyama, A and Ohama, T and Matsuura, F and Ishigami, M and Sakai, N and Hiraoka, H and Hattori, H and Wellington, C and Yoshida, Y and Misugi, S and Hayden, MR and Egashira, T and Yamashita, S and Matsuzawa, Y
DOI: 10.1006/bbrc.2001.6219
2002

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Nature Neuroscience
Panov, AV and Gutekunst, CA and Leavitt, BR and Hayden, MR and Burke, JR and Strittmatter, WJ and Greenamyre, JT
DOI: 10.1038/nn884
2002

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
Journal of Neuroscience
Wellington, CL and Ellerby, LM and Gutekunst, CA and Rogers, D and Warby, S and Graham, RK and Loubser, O and van Raamsdonk, J and Singaraja, R and Yang, YZ and Gafni, J and Bredesen, D and Hersch, SM and Leavitt, BR and Roy, S and Nicholson, DW and Hayden, MR
2002

Research

The Role of ABCA1 on Cellular Cholesterol Homeostasis and Beta-Cell Function
Type 2 diabetes is caused by the inability of endocrine cells in the pancreas to meet the increasing metabolic demands and insulin resistance brought on by obesity and ageing. Impaired ß-cell function is an early step in the pathogenesis of type 2 diabetes; however, the reasons for the development of ß-cell dysfunction in diabetes are not completely understood. One emerging theme is that the build-up of toxic lipids such as cholesterol leads to ß-cell destruction. ABCA1 regulates the removal of excess cellular cholesterol to an apolipoprotein receptor. We discovered that mice lacking ABCA1 have impaired glucose tolerance and that ABCA1 is highly expressed in islet cells of the pancreas. Using conditional gene targeting in mice to specifically inactivate Abca1 in ß-cells, we found that the lack of ABCA1 in these cells markedly impaired insulin secretion due to a cholesterol-dependent reduction in insulin granule exocytosis. We found that cholesterol efflux via ABCA1 is the primary contributor to maintenance of beta cell cholesterol homeostasis and that carriers of loss-of-function mutations in ABCA1 show impaired insulin secretion without any change in insulin sensitivity. We have recently shown that microRNA-33a (miR-33a) is expressed in pancreatic islets and in vitro modulation of its expression impacts ABCA1 protein levels in islets, thereby affecting intracellular cholesterol levels and insulin secretion. Our findings establish a novel role for ABCA1 in ß-cell cholesterol homeostasis and insulin secretion, and suggest that cholesterol accumulation may contribute to ß-cell dysfunction in type 2 diabetes, and point to ß-cell ABCA1 as a novel therapeutic target for this disease.

Silencing the gene that causes Huntington disease
The mutant huntingtin protein, the cause of Huntington disease (HD), accumulates within cells and engages in a variety of aberrant interactions. Preventing generation of this toxic protein by gene silencing, the process of switching off a gene, should prevent all subsequent pathology and prevent or delay the onset of HD. Everyone has two copies of the huntingtin gene. In HD, one of these copies carries the mutation while the other copy is normal. The normal huntingtin protein is important for maintaining neuronal health, and long-term reduction of this protein may not be well-tolerated. We are developing a strategy of silencing only the mutant copy of a patient’s huntingtin gene using antisense oligonucleotides targeted to HD mutation-associated single nucleotide polymorphisms as a treatment for HD.

The overall goal of this work is to delineate important steps in the pathogenesis of HD and to assess novel approaches to treating this disease.

Exploration of the Pathogenesis of Huntington's Disease and Evaluation of Novel Therapeutic Strategies
We have developed a YAC model for Huntington disease (HD) (YAC128) which displays age and CAG-dependent phenotypes that recapitulate many features of the human disease. Specifically, enhanced susceptibility to excitotoxic stress, protein cleavage and nuclear localization of (huntingtin) htt occurs early and precedes the cognitive dysfunction, motor deficits and selective striatal degeneration of HD.

We have recently provided compelling in vivo evidence that caspase-6 cleavage of mutant htt (mhtt) at amino acid (aa) 586 is a crucial, rate limiting event in the pathogenesis of HD. Mice expressing mhtt resistant to cleavage at the 586aa caspase-6 site (C6R) maintain normal neuronal function and do not develop cognitive or neurological abnormalities or any evidence of neurodegeneration. This represents the first intervention in any animal model for HD to prevent motor, cognitive and neuropathological features of HD. This finding supports further experiments to address critical questions including mechanisms for toxicity of the 586aa fragment, determination of initiating events leading to caspase-6 activation and whether decreasing levels of caspase-6 is associated with amelioration of HD.

The sequence of events between excitotoxicity and cleavage of htt is unknown. Alterations of the kynurenine pathway and NMDAR activity are early events in the pathogenesis of HD. Delineation of the natural history and the relationship between these features of excitotoxicity and cleavage of htt is crucial as it will provide data for designing effective therapeutic strategies for this disease. We will evaluate compounds known to modulate these two pathways, using reagents and approaches well established in our laboratory, in primary neuronal cultures and in the YAC128 model of HD to determine if these are viable therapeutic approaches for HD. If an excitotoxic insult is the upstream event that initiates cleavage of mhtt at the caspase-6 site, drugs that inhibit excitotoxicity would be expected to be associated with less cleavage as this site.

There is considerable evidence that post translational modification of htt by phosphorylation and palmitoylation play a role in the pathogenesis of HD. The mutation for HD disturbs the interaction of htt with the htt interacting protein 14 (Hip14), now known to be a palmitoyl-transferease leading to less palmitoylation of mhtt and enhanced neuronal toxicity. These findings directly link alterations in palmitoylation of htt with neurodegeneration in HD.

Grants

Team grant: Drug Safety and Effectiveness Network Collaborating Centre for Prospective Studies (DSEN PREVENT) (CIHR)

Regulation of Function and Activity of ABCA1 (CIHR)

Implementation of a Pharmacogenetic ADR Prevention Program in B.C. (Genome BC)

Honours & Awards

Inductee, Canadian Medical Hall of Fame, 2017

Honorary Doctorate, University of Gottingen, Germany, 2014

Aubrey J. Tingle Prize, Michael Smith Foundation for Health Research, 2011

Research Group Members

Nicholas Caron
Seetha Kumaran
Dawn Ng
Qingwen Xia
Evelyn Lomba
Louisa Dal Cengio
Philip Ly, Research Associate
Mandi Schmidt
Robert Tiszolczi
Galen Wright
Yun Seunghyun Ko
Lisa Anderson
Fanny Lemaire, Postdoctoral Fellow
Enzo Casal, Research Technician II
Stephanie Bortnick
Christopher Chris, Postdoctoral Fellow