Expanded access protocol (EAP) program for access to investigational products for amyotrophic lateral sclerosis (ALS).
Muscle & nerve
Yerton M and Winter A and Gelevski D and Addy G and Kostov A and Lieberman C and Weber H and Doyle M and Kane G and Caroline Cohen and Parikh N and Katherine M Burke and Rohrer M and Stirrat T and Bruno M and Hochman A and Luppino S and Scalia J and D'Agostino D and Sinani E and Yu H and Drake K and Hagar J and Sherman AV and Babu S and James D. Berry and Merit Cudkowicz and Sabrina Paganoni
DOI: 10.1002/mus.27819
PubMed: 36929648
04/2023

Axonal ER Ca²⁺ Release Selectively Enhances Activity-Independent Glutamate Release in a Huntington Disease Model.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mackay JP and Smith-Dijak AI and Koch ET and Zhang P and Fung E and Nassrallah WB and Buren C and Schmidt M and Michael R. Hayden and Lynn Raymond
DOI: 10.1523/jneurosci.1593-22.2023
PubMed: 36944490
03/2023

Pridopidine Does Not Significantly Prolong the QTc Interval at the Clinically Relevant Therapeutic Dose.
Neurology and therapy
Darpo B and Michal Geva and Ferber G and Goldberg YP and Cruz-Herranz A and Mehra M and Kovacs R and Michael R. Hayden
DOI: 10.1007/s40120-023-00449-w
PubMed: 36811812
02/2023

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation^S
Journal of Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.122.001435
2023

Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage
Frontiers in Physiology
Lemari{\'e}, F.L. and Sanders, S.S. and Nguyen, Y. and Martin, D.D.O. and Hayden, M.R.
DOI: 10.3389/fphys.2023.1086112
2023

Limitations of Dual-Single Guide RNA CRISPR Strategies for the Treatment of Central Nervous System Genetic Disorders
Human Gene Therapy
DOI: 10.1089/hum.2023.109
2023

Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks
Journal of Controlled Release
DOI: 10.1016/j.jconrel.2023.07.027
2023

Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease
Antioxidants and Redox Signaling
F{\~a}o, L. and Coelho, P. and Duarte, L. and Vila?a, R. and Hayden, M.R. and Mota, S.I. and Rego, A.C.
DOI: 10.1089/ars.2022.0001
2023

Preclinical Development and Characterization of Novel Adeno-Associated Viral Vectors for the Treatment of Lipoprotein Lipase Deficiency
Human Gene Therapy
DOI: 10.1089/hum.2023.075
2023

Allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models
BMC Biology
Joachimiak, P. and Ciesio?ka, A. and Koz?owska, E. and ?wito?ski, P.M. and Figura, G. and Cio?ak, A. and Adamek, G. and Surdyka, M. and Kalinowska-Po?ka, ?. and Figiel, M. and Caron, N.S. and Hayden, M.R. and Fiszer, A.
DOI: 10.1186/s12915-023-01515-3
2023

A PET-CT study on neuroinflammation in Huntington's disease patients participating in a randomized trial with laquinimod
Brain Communications
DOI: 10.1093/braincomms/fcad084
2023

Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice
Aging and Disease
DOI: 10.14336/AD.2023.0423
2023

Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy
bioRxiv
DOI: 10.1101/2023.10.11.561600
2023

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine
Autophagy
Wang, S.-M. and Wu, H.-E. and Yasui, Y. and Geva, M. and Hayden, M. and Maurice, T. and Cozzolino, M. and Su, T.-P.
DOI: 10.1080/15548627.2022.2063003
2023

Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models
Journal of Huntington's Disease
Chan, L.L. and Hill, A. and Lu, G. and Van Raamsdonk, J. and Gascoyne, R. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.3233/JHD-220554
2022

Huntingtin Over-Expression Does Not Alter Overall Survival in Murine Cancer Models
bioRxiv
Chan, L. and Hill, A. and Lu, G. and Van Raamsdonk, J. and Gascoyne, R.D. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1101/2022.09.11.507440
2022

Huntingtin expression influences spontaneous seizure disorder susceptibility in FVN/B mice
bioRxiv
Van Raamsdonk, J.M. and Al-Shekeli, H. and Wagner, L. and Bredy, T.W. and Chan, L. and Pearson, J. and Schwab, C. and Murphy, Z. and Devon, R.S. and Lu, G. and Kobor, M.S. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1101/2022.10.18.512787
2022

Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity
Brain Communications
Caron, N.S. and Haqqani, A.S. and Sandhu, A. and Aly, A.E. and Findlay Black, H. and Bone, J.N. and Mcbride, J.L. and Abulrob, A. and Stanimirovic, D. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1093/braincomms/fcac309
2022

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation
bioRxiv
DOI: 10.1101/2022.09.01.506269
2022

Mitochondrial and redox modifications in early stages of Huntington's disease
Redox Biology
DOI: 10.1016/j.redox.2022.102424
2022

Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model
Neurobiology of Disease
Lenoir, S. and Lahaye, R.A. and Vitet, H. and Scaramuzzino, C. and Virlogeux, A. and Capellano, L. and Genoux, A. and Gershoni-Emek, N. and Geva, M. and Hayden, M.R. and Saudou, F.
DOI: 10.1016/j.nbd.2022.105857
2022

Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans
Journal of Clinical Investigation
Zhong, S. and Ch{\`e}vre, R. and Mayan, D.C. and Corlian{\`o}, M. and Cochran, B.J. and Sem, K.P. and van Dijk, T.H. and Peng, J. and Tan, L.J. and Hartimath, S.V. and Ramasamy, B. and Cheng, P. and Groen, A.K. and Kuipers, F. and Goggi, J.L. and Drum, C. and van Dam, R.M. and Tan, R.S. and Rye, K.-A. and Hayden, M.R. and Cheng, C.-Y. and Chacko, S. and Flannick, J. and Sim, X. and Tan, H.C. and Singaraja, R.R.
DOI: 10.1172/JCI152961
2022

Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice
Neurobiology of Disease
Caron, N.S. and Banos, R. and Aly, A.E. and Xie, Y. and Ko, S. and Potluri, N. and Anderson, C. and Black, H.F. and Anderson, L.M. and Gordon, B. and Southwell, A.L. and Hayden, M.R.
DOI: 10.1016/j.nbd.2022.105652
2022

Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice
bioRxiv
Monteiro-Cardoso, V.F. and Yeo, X.Y. and Bae, H.-G. and Mayan, D.C. and Wehbe, M. and Lee, S. and Kumar Krishna, K. and Baek, S.H. and Palomera, L.F. and Shanmugam, S. and Sem, K.P. and Parsons, M.P. and Hayden, M.R. and Liehn, E.A. and Sajikumar, S. and Davanger, S. and Jo, D.-G. and Jung, S. and Singaraja, R.R.
DOI: 10.1101/2022.12.11.520005
2022

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity
Fanny L. Lemarié and Nicholas S. Caron and Shaun S. Sanders and Mandi E. Schmidt and Yen T.N. Nguyen and Seunghyun Ko and Xiaohong Xu and Mahmoud A. Pouladi and Dale D.O. Martin and Michael R. Hayden
DOI: 10.1101/2021.03.26.437210
03/2021

Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [¹⁸F] fluspidine and [¹⁸F] fallypride PET study
European Journal of Nuclear Medicine and Molecular Imaging
Grachev, I.D. and Meyer, P.M. and Becker, G.A. and Bronzel, M. and Marsteller, D. and Pastino, G. and Voges, O. and Rabinovich, L. and Knebel, H. and Zientek, F. and Rullmann, M. and Sattler, B. and Patt, M. and Gerhards, T. and Strauss, M. and Kluge, A. and Brust, P. and Savola, J.-M. and Gordon, M.F. and Geva, M. and Hesse, S. and Barthel, H. and Hayden, M.R. and Sabri, O.
DOI: 10.1007/s00259-020-05030-3
2021

The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models
Neurotherapeutics
Naia, L. and Ly, P. and Mota, S.I. and Lopes, C. and Maranga, C. and Coelho, P. and Gershoni-Emek, N. and Ankarcrona, M. and Geva, M. and Hayden, M.R. and Rego, A.C.
DOI: 10.1007/s13311-021-01022-9
2021

Sigma-1 receptor (S1r) interaction with cholesterol: Mechanisms of s1r activation and its role in neurodegenerative diseases
International Journal of Molecular Sciences
Zhemkov, V. and Geva, M. and Hayden, M.R. and Bezprozvanny, I.
DOI: 10.3390/ijms22084082
2021

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma
Scientific Reports
Geva, M. and Gershoni-Emek, N. and Naia, L. and Ly, P. and Mota, S. and Rego, A.C. and Hayden, M.R. and Levin, L.A.
DOI: 10.1038/s41598-021-01077-w
2021

Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting
Journal of Huntington's Disease
Caron, N.S. and Anderson, C. and Black, H.F. and Sanders, S.S. and Lemarié, F.L. and Doty, C.N. and Hayden, M.R.
DOI: 10.3233/JHD-200463
2021

Mutant huntingtin is cleared from the brain via active mechanisms in huntington disease
Journal of Neuroscience
Caron, N.S. and Banos, R. and Yanick, C. and Aly, A.E. and Byrne, L.M. and Smith, E.D. and Xie, Y. and Smith, S.E.P. and Potluri, N. and Black, H.F. and Casal, L. and Ko, S. and Cheung, D. and Kim, H. and Seong, I.S. and Wild, E.J. and Song, J.-J. and Hayden, M.R. and Southwell, A.L.
DOI: 10.1523/JNEUROSCI.1865-20.2020
2021

Small molecule splicing modifiers with systemic HTT-lowering activity
Nature Communications
Bhattacharyya, A. and Trotta, C.R. and Narasimhan, J. and Wiedinger, K.J. and Li, W. and Effenberger, K.A. and Woll, M.G. and Jani, M.B. and Risher, N. and Yeh, S. and Cheng, Y. and Sydorenko, N. and Moon, Y.-C. and Karp, G.M. and Weetall, M. and Dakka, A. and Gabbeta, V. and Naryshkin, N.A. and Graci, J.D. and Tripodi, T. and Southwell, A. and Hayden, M. and Colacino, J.M. and Peltz, S.W.
DOI: 10.1038/s41467-021-27157-z
2021

Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor
Journal of Neurochemistry
Shenkman, M. and Geva, M. and Gershoni-Emek, N. and Hayden, M.R. and Lederkremer, G.Z.
DOI: 10.1111/jnc.15366
2021

Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice
Neurobiology of Disease
Ravalia, A.S. and Lau, J. and Barron, J.C. and Purchase, S.L.M. and Southwell, A.L. and Hayden, M.R. and Nafar, F. and Parsons, M.P.
DOI: 10.1016/j.nbd.2021.105293
2021

Additional Safety and Exploratory Efficacy Data at 48 and 60 Months from Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease
Journal of Huntington's Disease
Andrew McGarry and Peggy Auinger and Karl Kieburtz and Michal Geva and Munish Mehra and Victor Abler and Igor D. Grachev and Mark Forrest Gordon and Juha-Matti Savola and Sanjay Gandhi and Spyridon Papapetropoulos and Michael Hayden
DOI: 10.3233/jhd-190393
06/2020

Effect of Pridopidine in Huntington Disease (HD) Patients and Healthy Volunteers (HVs) – A Simultaneous Sigma-1 Receptor PET/Multimodality MRI Study
58. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin
H Barthel and PM Meyer and M Rullmann and G Becker and M Bronzel and D Marsteller and O Voges and F Zientek and B Sattler and M Patt and E Strauss and A Kluge and JM Savola and MF Gordon and M Geva and S Hesse and M Hayden and ID Grachev and O Sabri
DOI: 10.1055/s-0040-1708414
04/2020

High sigma-1 receptor (S1R) and very low dopamine 2/dopamine 3 receptor (D2/D3R) occupancy at clinically relevant doses of pridopidine in healthy volunteers (HV) and Huntington disease patients (HD): a F-18-Fluspidine and F-18-Fallypride PET study
58. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin
PM Meyer and ID Grachev and GA Becker and M Bronzel and D Marsteller and O Voges and L Rabinovich and F Zientek and M Rullmann and B Sattler and M Patt and E Strauss and A Kluge and JM Savola and MF Gordon and M Geva and S Hesse and H Barthel and M Hayden and O Sabri
DOI: 10.1055/s-0040-1708168
04/2020

Axonal ER Ca2+ Release Enhances Miniature, but Reduces Activity-Dependent Glutamate Release in a Huntington Disease Model
Mackay JP and Smith-Dijak AI and Koch ET and Zhang P and Fung E and Nassrallah WB and Buren C and Schmidt M and Hayden MR and Raymond LA
DOI: 10.1101/2020.01.31.929299
01/2020

pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model
Cell Death and Disease
Xu, X. and Ng, B. and Sim, B. and Radulescu, C.I. and Yusof, N.A.B.M. and Goh, W.I. and Lin, S. and Lim, J.S.Y. and Cha, Y. and Kusko, R. and Kay, C. and Ratovitski, T. and Ross, C. and Hayden, M.R. and Wright, G. and Pouladi, M.A.
DOI: 10.1038/s41419-020-02983-z
2020

Tracing the mutated HTT and haplotype of the African ancestor who spread Huntington disease into the Middle East
Genetics in Medicine
Squitieri, F. and Mazza, T. and Maffi, S. and De Luca, A. and AlSalmi, Q. and AlHarasi, S. and Collins, J.A. and Kay, C. and Baine-Savanhu, F. and Landwhermeyer, B.G. and Sabatini, U. and Hayden, M.R.
DOI: 10.1038/s41436-020-0895-1
2020

Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range
Genetics in Medicine
Findlay Black, H. and Wright, G.E.B. and Collins, J.A. and Caron, N. and Kay, C. and Xia, Q. and Arning, L. and Bijlsma, E.K. and Squitieri, F. and Nguyen, H.P. and Hayden, M.R.
DOI: 10.1038/s41436-020-0917-z
2020

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease
Nucleic Acids Research
Caron, N.S. and Southwell, A.L. and Brouwers, C.C. and Cengio, L.D. and Xie, Y. and Black, H.F. and Anderson, L.M. and Ko, S. and Zhu, X. and Van Deventer, S.J. and Evers, M.M. and Konstantinova, P. and Hayden, M.R.
DOI: 10.1093/nar/gkz976
2020

Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
Cell Reports
Niu, J. and Sanders, S.S. and Jeong, H.-K. and Holland, S.M. and Sun, Y. and Collura, K.M. and Hernandez, L.M. and Huang, H. and Hayden, M.R. and Smith, G.M. and Hu, Y. and Jin, Y. and Thomas, G.M.
DOI: 10.1016/j.celrep.2020.108365
2020

Compromised IGF signaling causes caspase-6 activation in Huntington disease
Experimental Neurology
Skotte, N.H. and Pouladi, M.A. and Ehrnhoefer, D.E. and Huynh, K. and Qiu, X. and Nielsen, S.M.B. and Nielsen, T.T. and N?rrem?lle, A. and Hayden, M.R.
DOI: 10.1016/j.expneurol.2020.113396
2020

Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease
Neurobiology of Disease
Bartl, S. and Oueslati, A. and Southwell, A.L. and Siddu, A. and Parth, M. and David, L.S. and Maxan, A. and Salhat, N. and Burkert, M. and Mairhofer, A. and Friedrich, T. and Pankevych, H. and Balazs, K. and Staffler, G. and Hayden, M.R. and Cicchetti, F. and Smrzka, O.W.
DOI: 10.1016/j.nbd.2020.104943
2020

Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study
Journal of Huntington's Disease
McGarry, A. and Leinonen, M. and Kieburtz, K. and Geva, M. and Olanow, C.W. and Hayden, M.
DOI: 10.3233/JHD-200440
2020

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of huntington disease
Human Molecular Genetics
Wright, G.E.B. and Caron, N.S. and Ng, B. and Casal, L. and Casazza, W. and Xu, X. and Ooi, J. and Pouladi, M.A. and Mostafavi, S. and Ross, C.J.D. and Hayden, M.R.
DOI: 10.1093/hmg/ddaa184
2020

DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease
Frontiers in Cellular Neuroscience
Schmidt, M.E. and Caron, N.S. and Aly, A.E. and Lemarié, F.L. and Dal Cengio, L. and Ko, Y. and Lazic, N. and Anderson, L. and Nguyen, B. and Raymond, L.A. and Hayden, M.R.
DOI: 10.3389/fncel.2020.590569
2020

Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies
The Lancet Neurology
Wright, G.E.B. and Black, H.F. and Collins, J.A. and Gall-Duncan, T. and Caron, N.S. and Pearson, C.E. and Hayden, M.R.
DOI: 10.1016/S1474-4422(20)30343-4
2020

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons
Frontiers in Aging Neuroscience
Machiela, E. and Jeloka, R. and Caron, N.S. and Mehta, S. and Schmidt, M.E. and Baddeley, H.J.E. and Tom, C.M. and Polturi, N. and Xie, Y. and Mattis, V.B. and Hayden, M.R. and Southwell, A.L.
DOI: 10.3389/fnagi.2020.524369
2020

The interaction of aging and oxidative stress contributes to pathogenesis in mouse and human Huntington disease neurons
Emily Machiela and Ritika Jeloka and Nicholas S. Caron and Shagun Mehta and Mandi E. Schmidt and Colton M. Tom and Nalini Polturi and Yuanyun Xie and Virginia B Mattis and Michael R. Hayden and Amber L. Southwell
DOI: 10.1101/800268
10/2019

Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease
American Journal of Human Genetics
Wright, G.E.B. and Collins, J.A. and Kay, C. and McDonald, C. and Dolzhenko, E. and Xia, Q. and Be?anovi?, K. and Drögemöller, B.I. and Semaka, A. and Nguyen, C.M. and Trost, B. and Richards, F. and Bijlsma, E.K. and Squitieri, F. and Ross, C.J.D. and Scherer, S.W. and Eberle, M.A. and Yuen, R.K.C. and Hayden, M.R.
DOI: 10.1016/j.ajhg.2019.04.007
2019

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor
Neurobiology of Disease
Ryskamp, D. and Wu, L. and Wu, J. and Kim, D. and Rammes, G. and Geva, M. and Hayden, M. and Bezprozvanny, I.
DOI: 10.1016/j.nbd.2018.12.022
2019

Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes
Clinical Pharmacology and Therapeutics
Wright, G.E.B. and Amstutz, U. and Drögemöller, B.I. and Shih, J. and Rassekh, S.R. and Hayden, M.R. and Carleton, B.C. and Ross, C.J.D. and Visscher, H. and Aminkeng, F. and Higginson, M. and Massah, N. and Miao, F. and Bhavsar, A. and Lee, J. and Bendyshe-Walton, T. and Tanoshima, R. and Johnson, D. and Zhuwaki, C. and Honcharik, N. and Jong, G. and Israels, S. and Staub, M. and Rieder, M. and Faught, L. and Ito, S. and Nathan, P. and Karande, S. and Vaillancourt, R. and Johnston, D. and Nguyen, K. and Bussières, J.-F. and Lebel, D. and Jean-Louis, J.
DOI: 10.1002/cpt.1179
2019

In search of a genetic explanation for LDLc variability in an FH family: Common SNPs and a rare mutation in MTTP explain only part of LDL variability in an FH family
Journal of Lipid Research
Winther, M. and Shpitzen, S. and Yaacov, O. and Landau, J. and Oren, L. and Foroozan-Rosenberg, L. and Cohain, N.L. and Schurr, D. and Meiner, V. and Szalat, A. and Carmi, S. and Hayden, M.R. and Leitersdorf, E. and Durst, R.
DOI: 10.1194/jlr.M092049
2019

Altered regulation of striatal neuronal N-methyl-D-aspartate receptor trafficking by palmitoylation in Huntington disease mouse model
Frontiers in Synaptic Neuroscience
Kang, R. and Wang, L. and Sanders, S.S. and Zuo, K. and Hayden, M.R. and Raymond, L.A.
DOI: 10.3389/fnsyn.2019.00003
2019

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1 ^G93A Model
Cell Death and Disease
Ionescu, A. and Gradus, T. and Altman, T. and Maimon, R. and Saraf Avraham, N. and Geva, M. and Hayden, M. and Perlson, E.
DOI: 10.1038/s41419-019-1451-2
2019

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease
Neurotherapeutics
Francardo, V. and Geva, M. and Bez, F. and Denis, Q. and Steiner, L. and Hayden, M.R. and Cenci, M.A.
DOI: 10.1007/s13311-018-00699-9
2019

Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease
bioRxiv
Wright, G.E.B. and Collins, J.A. and Kay, C. and McDonald, C. and Dolzhenko, E. and Xia, Q. and Be?anovi?, K. and Semaka, A. and Nguyen, C.M. and Trost, B. and Richards, F. and Bijlsma, E.K. and Squitieri, F. and Scherer, S.W. and Eberle, M.A. and Yuen, R.K.C. and Hayden, M.R.
DOI: 10.1101/533414
2019

Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease
Molecular Neurobiology
Garcia-Miralles, M. and Yusof, N.A.B.M. and Tan, J.Y. and Radulescu, C.I. and Sidik, H. and Tan, L.J. and Belinson, H. and Zach, N. and Hayden, M.R. and Pouladi, M.A.
DOI: 10.1007/s12035-018-1393-1
2019

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease
Proceedings of the National Academy of Sciences of the United States of America
Bardile, C.F. and Garcia-Miralles, M. and Caron, N.S. and Rayan, N.A. and Langley, S.R. and Harmston, N. and Rondelli, A.M. and Yi Teo, R.T. and Waltl, S. and Anderson, L.M. and Bae, H.-G. and Jung, S. and Williams, A. and Prabhakar, S. and Petretto, E. and Hayden, M.R. and Pouladi, M.A.
DOI: 10.1073/pnas.1818042116
2019

Impairment and restoration of homeostatic plasticity in cultured cortical neurons from a mouse model of huntington disease
Frontiers in Cellular Neuroscience
Smith-Dijak, A.I. and Nassrallah, W.B. and Zhang, L.Y.J. and Geva, M. and Hayden, M.R. and Raymond, L.A.
DOI: 10.3389/fncel.2019.00209
2019

Clinical management of huntington's disease: The role of pet and dna linkage studies
Functional Imaging in Movement Disorders
2019

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
Cell Chemical Biology
Ehrnhoefer, D.E. and Skotte, N.H. and Reinshagen, J. and Qiu, X. and Windshügel, B. and Jaishankar, P. and Ladha, S. and Petina, O. and Khankischpur, M. and Nguyen, Y.T.N. and Caron, N.S. and Razeto, A. and Meyer zu Rheda, M. and Deng, Y. and Huynh, K.T. and Wittig, I. and Gribbon, P. and Renslo, A.R. and Geffken, D. and Gul, S. and Hayden, M.R.
DOI: 10.1016/j.chembiol.2019.07.001
2019

Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices
Digital Biomarkers
Gordon, M.F. and Grachev, I.D. and Mazeh, I. and Dolan, Y. and Reilmann, R. and Loupe, P.S. and Fine, S. and Navon-Perry, L. and Gross, N. and Papapetropoulos, S. and Savola, J.-M. and Hayden, M.R.
DOI: 10.1159/000502136
2019

A Comprehensive Haplotype-Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease
American Journal of Human Genetics
Kay, C. and Collins, J.A. and Caron, N.S. and Agostinho, L.D.A. and Findlay-Black, H. and Casal, L. and Sumathipala, D. and Dissanayake, V.H.W. and Cornejo-Olivas, M. and Baine, F. and Krause, A. and Greenberg, J.L. and Paiva, C.L.A. and Squitieri, F. and Hayden, M.R.
DOI: 10.1016/j.ajhg.2019.10.011
2019

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques
Movement Disorders
Johnston, T.H. and Geva, M. and Steiner, L. and Orbach, A. and Papapetropoulos, S. and Savola, J.-M. and Reynolds, I.J. and Ravenscroft, P. and Hill, M. and Fox, S.H. and Brotchie, J.M. and Laufer, R. and Hayden, M.R.
DOI: 10.1002/mds.27565
2019

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance
FASEB Journal
Martin, D.D.O. and Schmidt, M.E. and Nguyen, Y.T. and Lazic, N. and Hayden, M.R.
DOI: 10.1096/fj.201701510RRR
2019

Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study
The Lancet Neurology
Reilmann, R. and McGarry, A. and Grachev, I.D. and Savola, J.-M. and Borowsky, B. and Eyal, E. and Gross, N. and Langbehn, D. and Schubert, R. and Wickenberg, A.T. and Papapetropoulos, S. and Hayden, M. and Squitieri, F. and Kieburtz, K. and Landwehrmeyer, G.B. and Agarwal, P. and Anderson, K.E. and Aziz, N.A. and Azulay, J.-P. and Bachoud-Levi, A.C. and Barker, R. and Bebak, A. and Beuth, M. and Biglan, K. and Blin, S. and Bohlen, S. and Bonelli, R. and Caldwell, S. and Calvas, F. and Carlos, J. and Castagliuolo, S. and Chong, T. and Chua, P. and Coleman, A. and Corey-Bloom, J. and Cousins, R. and Craufurd, D. and Davison, J. and Decorte, E. and De Michele, G. and Dornhege, L. and Feigin, A. and Gallehawk, S. and Gauteul, P. and Gonzales, C. and Griffith, J. and Gustov, A. and Guttman, M. and Heim, B. and Heller, H. and Hjermind, L. and Illarioshkin, S. and Ivanko, L. and Jaynes, J. and Jenckes, M. and Kaminski, B. and Kampstra, A. and Konkel, A. and Kopishinskaya, S. and Krystkowiak, P. and Komati, S.K. and Kwako, A. and Lakoning, S. and Latipova, G. and Leavitt, B. and Loy, C. and MacFarlane, C. and Madsen, L. and Marder, K. and Mason, S. and Mendis, N. and Mendis, T. and Nemeth, A. and Nevitt, L. and Norris, V. and O'Neill, C. and Olivier, A. and Orth, M. and Owens, A. and Panegyres, P. and Perlman, S. and Preston, J. and Priller, J. and Puch, A. and Quarrell, O. and Ragosta, D. and Rialland, A. and Rickards, H. and Romoli, A.M. and Ross, C. and Rosser, A. and Rudzinska, M. and Russo, C.V. and Saft, C. and Segro, V. and Seppi, K. and Shannon, B. and Shprecher, D. and Simonin, C. and Skitt, Z. and Slawek, J. and Soliveri, P. and Sorbi, S. and Suski, V. and Stepniak, I. and Sungmee, P. and Temirbaeva, S. and Testa, C. and Torvin-Moller, A. and Uhl, S. and Vangsted-Hansen, C. and Verny, C. and Wall, P. and Walker, F. and Wasserman, P. and Witkowski, G. and Wright, J. and Zalyalova, Z. and Zielonka, D.
DOI: 10.1016/S1474-4422(18)30391-0
2019

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor
Neurobiology of Disease
Eddings, C.R. and Arbez, N. and Akimov, S. and Geva, M. and Hayden, M.R. and Ross, C.A.
DOI: 10.1016/j.nbd.2019.05.009
2019

Synaptopathy, circuitopathy and the computational biology of Huntington's disease.
BMC biology
DOI: 10.1186/s12915-018-0539-y
PubMed: 29945620
06/2018

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease
BMC Biology
Schmidt, M.E. and Buren, C. and Mackay, J.P. and Cheung, D. and Dal Cengio, L. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1186/s12915-018-0526-3
2018

Therapeutic approaches to huntington disease: From the bench to the clinic
Nature Reviews Drug Discovery
Caron, N.S. and Dorsey, E.R. and Hayden, M.R.
DOI: 10.1038/nrd.2018.133
2018

Physicochemical, biological, functional and toxicological characterization of the European follow-on glatiramer acetate product as compared with Copaxone
eNeurologicalSci
Melamed-Gal, S. and Loupe, P. and Timan, B. and Weinstein, V. and Kolitz, S. and Zhang, J. and Funt, J. and Komlosh, A. and Ashkenazi, N. and Bar-Ilan, O. and Konya, A. and Beriozkin, O. and Laifenfeld, D. and Hasson, T. and Krispin, R. and Molotsky, T. and Papir, G. and Sulimani, L. and Zeskind, B. and Liu, P. and Nock, S. and Hayden, M.R. and Gilbert, A. and Grossman, I.
DOI: 10.1016/j.ensci.2018.05.006
2018

Genetic ablation of cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition
American Journal of Physiology - Endocrinology and Metabolism
Patankar, J.V. and Wong, C.K. and Morampudi, V. and Gibson, W.T. and Vallance, B. and Ioannou, G.N. and Hayden, M.R.
DOI: 10.1152/ajpendo.00172.2017
2018

Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients
Clinical Cancer Research
Drogemoller, B.I. and Brooks, B. and Critchley, C. and Monzon, J.G. and Wright, G.E.B. and Liu, G. and Renouf, D.J. and Kollmannsberger, C.K. and Bedard, P.L. and Hayden, M.R. and Gelmon, K.A. and Carleton, B.C. and Ross, C.J.D.
DOI: 10.1158/1078-0432.CCR-17-2810
2018

The global spectrum of protein-coding pharmacogenomic diversity
Pharmacogenomics Journal
Wright, G.E.B. and Carleton, B. and Hayden, M.R. and Ross, C.J.D.
DOI: 10.1038/tpj.2016.77
2018

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Human Molecular Genetics
Ehrnhoefer, D.E. and Southwell, A.L. and Sivasubramanian, M. and Qiu, X. and Villanueva, E.B. and Xie, Y. and Waltl, S. and Anderson, L. and Fazeli, A. and Casal, L. and Felczak, B. and Tsang, M. and Hayden, M.R.
DOI: 10.1093/hmg/ddx394
2018

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease
Biochimica et Biophysica Acta - Molecular Basis of Disease
Silva, A.C. and Ferreira, I.L. and Hayden, M.R. and Ferreiro, E. and Rego, A.C.
DOI: 10.1016/j.bbadis.2017.09.009
2018

Therapeutic modulation of the bile acid pool by cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice
FASEB Journal
Chevre, R. and Trigueros-Motos, L. and Castaño, D. and Chua, T. and Corliano, M. and Patankar, J.V. and Sng, L. and Sim, L. and Juin, T.L. and Carissimo, G. and Ng, L.F.P. and Jia Yi, C.N. and Eliathamby, C.C. and Groen, A.K. and Hayden, M.R. and Singaraja, R.R.
DOI: 10.1096/fj.201701084RR
2018

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
Molecular Neurodegeneration
Kusko, R. and Dreymann, J. and Ross, J. and Cha, Y. and Escalante-Chong, R. and Garcia-Miralles, M. and Tan, L.J. and Burczynski, M.E. and Zeskind, B. and Laifenfeld, D. and Pouladi, M. and Geva, M. and Grossman, I. and Hayden, M.R.
DOI: 10.1186/s13024-018-0259-3
2018

A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes
Human Molecular Genetics
Petrella, L.I. and Castelhano, J.M. and Ribeiro, M. and Sereno, J.V. and Gon?alves, S.I. and La?o, M.N. and Hayden, M.R. and Cristina Rego, A. and Castelo-Branco, M.
DOI: 10.1093/hmg/ddy119
2018

The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Kay, C. and Collins, J.A. and Wright, G.E.B. and Baine, F. and Miedzybrodzka, Z. and Aminkeng, F. and Semaka, A.J. and McDonald, C. and Davidson, M. and Madore, S.J. and Gordon, E.S. and Gerry, N.P. and Cornejo-Olivas, M. and Squitieri, F. and Tishkoff, S. and Greenberg, J.L. and Krause, A. and Hayden, M.R.
DOI: 10.1002/ajmg.b.32618
2018

Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli
Cell Death Discovery
Ladha, S. and Qiu, X. and Casal, L. and Caron, N.S. and Ehrnhoefer, D.E. and Hayden, M.R.
DOI: 10.1038/s41420-018-0043-8
2018

A human huntingtin SNP alters post-Translational modification and pathogenic proteolysis of the protein causing Huntington disease
Scientific Reports
Martin, D.D.O. and Kay, C. and Collins, J.A. and Nguyen, Y.T. and Slama, R.A. and Hayden, M.R.
DOI: 10.1038/s41598-018-25903-w
2018

Response to the Letter-to-the Editor by Cohen et al. concerning our eNeurologicalSci article, Melamed-Gal, et al. Physicochemical, biological, functional and toxicological characterization of the European follow-on glatiramer acetate product as compared with Copaxone. eNeurologicalSci 2018;12:19–30.https://doi.org/10.1016/j.ensci.2018.05.006
eNeurologicalSci
Melamed-Gal, S. and Loupe, P. and Timan, B. and Weinstein, V. and Kolitz, S. and Zhang, J. and Funt, J. and Komlosh, A. and Ashkenazi, N. and Bar-Ilan, O. and Konya, A. and Beriozkin, O. and Laifenfeld, D. and Hasson, T. and Zeskind, B. and Hayden, M. and Nock, S. and Grossman, I.
DOI: 10.1016/j.ensci.2018.11.007
2018

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
Acta neuropathologica communications
Ehrnhoefer, D.E. and Martin, D.D.O. and Schmidt, M.E. and Qiu, X. and Ladha, S. and Caron, N.S. and Skotte, N.H. and Nguyen, Y.T.N. and Vaid, K. and Southwell, A.L. and Engemann, S. and Franciosi, S. and Hayden, M.R.
DOI: 10.1186/s40478-018-0518-0
2018

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Science Translational Medicine
Southwell, A.L. and Kordasiewicz, H.B. and Langbehn, D. and Skotte, N.H. and Parsons, M.P. and Villanueva, E.B. and Caron, N.S. and Ostergaard, M.E. and Anderson, L.M. and Xie, Y. and Cengio, L.D. and Findlay-Black, H. and Doty, C.N. and Fitsimmons, B. and Swayze, E.E. and Seth, P.P. and Raymond, L.A. and Bennett, C.F. and Hayden, M.R.
DOI: 10.1126/scitranslmed.aar3959
2018

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.
JCI insight
DOI: 10.1172/jci.insight.95665
PubMed: 29212949
12/2017

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
Neurology
DOI: 10.1212/WNL.0000000000004853
PubMed: 29288229
12/2017

Reduction of mutant huntingtin in oligodendroglia rescues myelination and behavioural deficits in a model of Huntington disease
Journal of Neurochemistry
08/2017

A novel humanizedmouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Human Molecular Genetics
Southwell, A.L. and Skotte, N.H. and Villanueva, E.B. and ?stergaard, M.E. and Gu, X. and Kordasiewicz, H.B. and Kay, C. and Cheung, D. and Xie, Y. and Waltl, S. and Cengio, L.D. and Findlay-Black, H. and Doty, C.N. and Petoukhov, E. and Iworima, D. and Slama, R. and Ooi, J. and Pouladi, M.A. and Yang, X.W. and Swayze, E.E. and Seth, P.P. and Hayden, M.R.
DOI: 10.1093/hmg/ddx021
2017

Pharmacogenomics strategies to optimize treatments for multiple sclerosis: Insights from clinical research
Progress in Neurobiology
Grossman, I. and Knappertz, V. and Laifenfeld, D. and Ross, C. and Zeskind, B. and Kolitz, S. and Ladkani, D. and Hayardeny, L. and Loupe, P. and Laufer, R. and Hayden, M.
DOI: 10.1016/j.pneurobio.2016.02.001
2017

Evaluation of pridopidine in the transgenic YAC128 mouse model of Huntington disease
Journal of Neurochemistry
Garcia-Miralles, M. and Yosuf, Nabm and Tan, J. Y. and Kusko, R. and Tan, L. J. and Xu, X. and Orbach, A. and Geva, M. and Hayden, M. R. and Pouladi, M. A.
2017

Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model
Annals of the New York Academy of Sciences
Grossman, I. and Kolitz, S. and Komlosh, A. and Zeskind, B. and Weinstein, V. and Laifenfeld, D. and Gilbert, A. and Bar-Ilan, O. and Fowler, K.D. and Hasson, T. and Konya, A. and Wells-Knecht, K. and Loupe, P. and Melamed-Gal, S. and Molotsky, T. and Krispin, R. and Papir, G. and Sahly, Y. and Hayden, M.R.
DOI: 10.1111/nyas.13547
2017

Association between slc16a5 genetic variation and cisplatin-induced ototoxic effects in adult patients with testicular cancer
JAMA Oncology
Drögemöller, B.I. and Monzon, J.G. and Bhavsar, A.P. and Borrie, A.E. and Brooks, B. and Wright, G.E.B. and Liu, G. and Renouf, D.J. and Kollmannsberger, C.K. and Bedard, P.L. and Aminkeng, F. and Amstutz, U. and Hildebrand, C.A. and Gunaretnam, E.P. and Critchley, C. and Chen, Z. and Brunham, L.R. and Hayden, M.R. and Ross, C.J.D. and Gelmon, K.A. and Carleton, B.C.
DOI: 10.1001/jamaoncol.2017.0502
2017

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease
Neurobiology of Disease
Ryskamp, D. and Wu, J. and Geva, M. and Kusko, R. and Grossman, I. and Hayden, M. and Bezprozvanny, I.
DOI: 10.1016/j.nbd.2016.10.006
2017

Laquinimod treatment in the R6/2 mouse model
Scientific Reports
Ellrichmann, G. and Blusch, A. and Fatoba, O. and Brunner, J. and Hayardeny, L. and Hayden, M. and Sehr, D. and Winklhofer, K.F. and Saft, C. and Gold, R.
DOI: 10.1038/s41598-017-04990-1
2017

ABCA8 regulates cholesterol efflux and high-density lipoprotein cholesterol levels
Arteriosclerosis, Thrombosis, and Vascular Biology
Trigueros-Motos, L. and Van Capelleveen, J.C. and Torta, F. and Castao, D. and Zhang, L.-H. and Chai, E.C. and Kang, M. and Dimova, L.G. and Schimmel, A.W.M. and Tietjen, I. and Radomski, C. and Tan, L.J. and Thiam, C.H. and Narayanaswamy, P. and Wu, D.H. and Dorninger, F. and Yakala, G.K. and Barhdadi, A. and Angeli, V. and Dub, M.-P. and Berger, J. and Dallinga-Thie, G.M. and Tietge, U.J.F. and Wenk, M.R. and Hayden, M.R. and Kees Hovingh, G. and Singaraja, R.R.
DOI: 10.1161/ATVBAHA.117.309574
2017

The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America
European Journal of Human Genetics
Kay, C. and Tirado-Hurtado, I. and Cornejo-Olivas, M. and Collins, J.A. and Wright, G. and Inca-Martinez, M. and Veliz-Otani, D. and Ketelaar, M.E. and Slama, R.A. and Ross, C.J. and Mazzetti, P. and Hayden, M.R.
DOI: 10.1038/ejhg.2016.169
2017

Neurodegeneration: Role of repeats in protein clearance
Nature
Martin, D.D.O. and Hayden, M.R.
DOI: 10.1038/nature22489
2017

Histone deacetylase inhibitors protect against pyruvate dehydrogenase dysfunction in huntington’s disease
Journal of Neuroscience
Naia, L. and Cunha-Oliveira, T. and Rodrigues, J. and Rosenstock, T.R. and Oliveira, A. and Ribeiro, M. and Carmo, C. and Oliveira-Sousa, S.I. and Duarte, A.I. and Hayden, M.R. and Rego, A.C.
DOI: 10.1523/JNEUROSCI.2006-14.2016
2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer
British Journal of Clinical Pharmacology
Aminkeng, F. and Ross, C.J.D. and Rassekh, S.R. and Rieder, M.J. and Bhavsar, A.P. and Sanatani, S. and Bernstein, D. and Hayden, M.R. and Amstutz, U. and Carleton, B.C.
DOI: 10.1111/bcp.13218
2017

eEF2K inhibition blocks Aß42 neurotoxicity by promoting an NRF2 antioxidant response
Acta Neuropathologica
Jan, A. and Jansonius, B. and Delaidelli, A. and Somasekharan, S.P. and Bhanshali, F. and Vandal, M. and Negri, G.L. and Moerman, D. and MacKenzie, I. and Calon, F. and Hayden, M.R. and Taubert, S. and Sorensen, P.H.
DOI: 10.1007/s00401-016-1634-1
2017

Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models
Molecular Neurobiology
Naia, L. and Rosenstock, T.R. and Oliveira, A.M. and Oliveira-Sousa, S.I. and Caldeira, G.L. and Carmo, C. and La?o, M.N. and Hayden, M.R. and Oliveira, C.R. and Rego, A.C.
DOI: 10.1007/s12035-016-0048-3
2017

Author response: Huntington disease reduced penetrance alleles occur at high frequency in the general population
Neurology
Hayden, M.R. and Kay, C.
DOI: 10.1212/WNL.0000000000003528
2017

Palmitoylation of caspase-6 by HIP14 regulates its activation
Cell Death and Differentiation
Skotte, N.H. and Sanders, S.S. and Singaraja, R.R. and Ehrnhoefer, D.E. and Vaid, K. and Qiu, X. and Kannan, S. and Verma, C. and Hayden, M.R.
DOI: 10.1038/cdd.2016.139
2017

Feeding schedule and proteolysis regulate autophagic clearance of mutant huntingtin
bioRxiv
Ehrnhoefer, D.E. and Martin, D.D.O. and Qiu, X. and Ladha, S. and Caron, N.S. and Skotte, N.H. and Nguyen, Y.T.N. and Engemann, S. and Franciosi, S. and Hayden, M.R.
DOI: 10.1101/116178
2017

Safety and Exploratory Efficacy at 36 Months in Open-HART, an Open-Label Extension Study of Pridopidine in Huntington's Disease
Journal of Huntington's Disease
McGarry, A. and Kieburtz, K. and Abler, V. and Grachev, I.D. and Gandhi, S. and Auinger, P. and Papapetropoulos, S. and Hayden, M.
DOI: 10.3233/JHD-170241
2017

Beyond Motor Effects-Pridopidine's New Therapeutic Potential
Neurotherapeutics
Geva, M. and Kusko, R. and Ryskamp, D. and Bezprozvanny, I. and Grossman, I. and Orbach, A. and Burczynski, M. and Papapetropoulos, S. and Laufer, R. and Hayden, M. R.
2017

Epidemiology of Huntington disease
Handbook of Clinical Neurology
DOI: 10.1016/B978-0-12-801893-4.00003-1
2017

A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis
Genome Medicine
Ross, C.J. and Towfic, F. and Shankar, J. and Laifenfeld, D. and Thoma, M. and Davis, M. and Weiner, B. and Kusko, R. and Zeskind, B. and Knappertz, V. and Grossman, I. and Hayden, M.R.
DOI: 10.1186/s13073-017-0436-y
2017

Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.
Therapeutic drug monitoring
DOI: 10.1097/ftd.0000000000000298
PubMed: 26960170
08/2016

A true mentor and pioneer in medical genetics
South African Medical Journal
Hayden, M.R.
DOI: 10.7196/SAMJ.2016.v106i6.11022
2016

Pharmacogenomic Strategies for the Prevention of Anthracycline-Induced Heart Failure: Validation of a Genetic Association with a Non-Synonymous Variant in RARG
Pediatric Blood & Cancer
Bhavsar, A. P. and Rassekh, S. R. and Aminkeng, F. and Li, Y. and Gunaretnam, E. and Rieder, M. J. and Bernstein, D. and Hayden, M. R. and Carleton, B. C. and Ross, C. J. D.
2016

Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice
BMC Biology
Sanders, S.S. and Parsons, M.P. and Mui, K.K.N. and Southwell, A.L. and Franciosi, S. and Cheung, D. and Waltl, S. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1186/s12915-016-0333-7
2016

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes
Scientific Reports
Maillet, A. and Tan, K. and Chai, X. and Sadananda, S.N. and Mehta, A. and Ooi, J. and Hayden, M.R. and Pouladi, M.A. and Ghosh, S. and Shim, W. and Brunham, L.R.
DOI: 10.1038/srep25333
2016

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
Scientific Reports
Garcia-Miralles, M. and Hong, X. and Tan, L.J. and Caron, N.S. and Huang, Y. and To, X.V. and Lin, R.Y. and Franciosi, S. and Papapetropoulos, S. and Hayardeny, L. and Hayden, M.R. and Chuang, K.-H. and Pouladi, M.A.
DOI: 10.1038/srep31652
2016

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes
Human Molecular Genetics
Southwell, A.L. and Smith-Dijak, A. and Kay, C. and Sepers, M. and Villanueva, E.B. and Parsons, M.P. and Xie, Y. and Anderson, L. and Felczak, B. and Waltl, S. and Ko, S. and Cheung, D. and Cengio, L.D. and Slama, R. and Petoukhov, E. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1093/hmg/ddw212
2016

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease
Human Molecular Genetics
Yi Teo, R.T. and Hong, X. and Yu-Taeger, L. and Huang, Y. and Tan, L.J. and Xie, Y. and To, X.V. and Guo, L. and Rajendran, R. and Novati, A. and Calaminus, C. and Riess, O. and Hayden, M.R. and Nguyen, H.P. and Chuang, K.-H. and Pouladi, M.A.
DOI: 10.1093/hmg/ddw122
2016

Similarities and differences in the gene expression profiles of glatopa and copaxone
Multiple Sclerosis Journal
Kolitz, S. and Laifenfeld, D. and Fowler, K. and Hasson, T. and Konya, A. and Bakshi, S. and Zeskind, B. and Grossman, I. and Hayden, M. R.
2016

Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons
Experimental Neurology
Ehrnhoefer, D.E. and Caron, N.S. and Deng, Y. and Qiu, X. and Tsang, M. and Hayden, M.R.
DOI: 10.1016/j.expneurol.2016.06.008
2016

Huntington disease reduced penetrance alleles occur at high frequency in the general population
Neurology
Kay, C. and Collins, J.A. and Miedzybrodzka, Z. and Madore, S.J. and Gordon, E.S. and Gerry, N. and Davidson, M. and Slama, R.A. and Hayden, M.R.
DOI: 10.1212/WNL.0000000000002858
2016

Functional effects of the antigen glatiramer acetate are complex and tightly associated with its composition
Journal of Neuroimmunology
Hasson, T. and Kolitz, S. and Towfic, F. and Laifenfeld, D. and Bakshi, S. and Beriozkin, O. and Shacham-Abramson, M. and Timan, B. and Fowler, K.D. and Birnberg, T. and Konya, A. and Komlosh, A. and Ladkani, D. and Hayden, M.R. and Zeskind, B. and Grossman, I.
DOI: 10.1016/j.jneuroim.2015.11.020
2016

Anti-SEMA4D Antibody Ameliorates Pathogenic Processes in Central Nervous System, Cognitive Impairment in the YAC128 Mouse Model of Huntington Disease, and is Well-tolerated in Patients
Neurotherapeutics
Zauderer, M. and Klimatcheva, E. and Fisher, T. and Reilly, C. and Winter, L. and Mallow, C. and Bussler, H. and Torno, S. and Howell, A. and Scrivens, M. and Balch, L. and Wang, W. and Paris, M. and Evans, E. and Southwell, A. and Hayden, M. and Leonard, J. and Smith, E.
2016

The Aryl Hydrocarbon Receptor in the Peripheral Immune System is the Molecular Target of Laquinimod in MOG induced Experimental Autoimmune Encephalomyelitis
Multiple Sclerosis Journal
Kaye, J. and Birnberg, T. and Hingaly, T. and Raymond, E. and Piryatinsky, V. and Caballero, I. and Orbach, A. and Grossman, I. and Knappertz, V. and Hayden, M. R. and Laufer, R.
2016

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity
British Journal of Clinical Pharmacology
Aminkeng, F. and Ross, C.J.D. and Rassekh, S.R. and Hwang, S. and Rieder, M.J. and Bhavsar, A.P. and Smith, A. and Sanatani, S. and Gelmon, K.A. and Bernstein, D. and Hayden, M.R. and Amstutz, U. and Carleton, B.C.
DOI: 10.1111/bcp.13008
2016

MITIGATE-HD: A Trial of Memantine in Huntington Disease
Neurotherapeutics
Petkau, T. and Sturrock, A. and Coleman, A. and Mackay, A. and Russell-Schulz, B. and Langbehn, D. and Hayden, M. R. and Leavitt, B. R.
2016

Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells
Journal of Neurochemistry
Dobson, L. and Träger, U. and Farmer, R. and Hayardeny, L. and Loupe, P. and Hayden, M.R. and Tabrizi, S.J.
DOI: 10.1111/jnc.13553
2016

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor
Proceedings of the National Academy of Sciences of the United States of America
Kaye, J. and Piryatinsky, V. and Birnberg, T. and Hingaly, T. and Raymond, E. and Kashi, R. and Amit-Romach, E. and Caballero, I.S. and Towfic, F. and Ator, M.A. and Rubinstein, E. and Laifenfeld, D. and Orbach, A. and Shinar, D. and Marantz, Y. and Grossman, I. and Knappertz, V. and Hayden, M.R. and Laufer, R.
DOI: 10.1073/pnas.1607843113
2016

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease
Experimental Neurology
Garcia-Miralles, M. and Ooi, J. and Ferrari Bardile, C. and Tan, L.J. and George, M. and Drum, C.L. and Lin, R.Y. and Hayden, M.R. and Pouladi, M.A.
DOI: 10.1016/j.expneurol.2016.01.019
2016

Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: Implications for clinical implementation of pharmacogenomics
Pharmacogenetics and Genomics
Chan, S.L. and Samaranayake, N. and Ross, C.J.D. and Toh, M.T. and Carleton, B. and Hayden, M.R. and Teo, Y.Y. and Dissanayake, V.H.W. and Brunham, L.R.
DOI: 10.1097/FPC.0000000000000182
2016

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease
Molecular Therapy - Nucleic Acids
Miniarikova, J. and Zanella, I. and Huseinovic, A. and van der Zon, T. and Hanemaaijer, E. and Martier, R. and Koornneef, A. and Southwell, A.L. and Hayden, M.R. and van Deventer, S.J. and Petry, H. and Konstantinova, P.
DOI: 10.1038/mtna.2016.7
2016

Similarities and differences in the gene expression profiles of copaxone and polimunol
Multiple Sclerosis Journal
Laifenfeld, D. and Hasson, T. and Kolitz, S. E. and Fowler, K. D. and Konya, A. and Bakshi, S. and Zeskind, B. and Grossman, I. and Hayden, M. R.
2016

Rationale and Design for LEGATO-HD Study: A Multinational, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Laquinimod (0.5, 1.0, and 1.5 mg/day) as Treatment in Patients with Huntington Disease
Neurotherapeutics
Reilmann, R. and Tabrizi, S. and Leavitt, B. and Stout, J. C. and Piccini, P. and Anderson, K. E. and Feigin, A. and Hayden, M. and Grozinski-Wolff, M. and Eyal, E. and Papapetropoulos, S.
2016

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin
Neuropeptides
Naia, L. and Ribeiro, M. and Rodrigues, J. and Duarte, A.I. and Lopes, C. and Rosenstock, T.R. and Hayden, M.R. and Rego, A.C.
DOI: 10.1016/j.npep.2016.01.009
2016

Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin
Neuroscience
Connolly, C. and Magnusson-Lind, A. and Lu, G. and Wagner, P.K. and Southwell, A.L. and Hayden, M.R. and Björkqvist, M. and Leavitt, B.R.
DOI: 10.1016/j.neuroscience.2016.03.031
2016

Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: A pharmacogenetic study
Brain
Masellis, M. and Collinson, S. and Freeman, N. and Tampakeras, M. and Levy, J. and Tchelet, A. and Eyal, E. and Berkovich, E. and Eliaz, R.E. and Abler, V. and Grossman, I. and Fitzer-Attas, C. and Tiwari, A. and Hayden, M.R. and Kennedy, J.L. and Lang, A.E. and Knight, J.
DOI: 10.1093/brain/aww109
2016

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice
Diabetologia
Wijesekara, N. and Kaur, A. and Westwell-Roper, C. and Nackiewicz, D. and Soukhatcheva, G. and Hayden, M.R. and Verchere, C.B.
DOI: 10.1007/s00125-016-3907-6
2016

A novel microdeletion affecting the CETP gene raises HDL-associated cholesterol levels
Clinical Genetics
Hitchcock, E. and Patankar, J.V. and Tyson, C. and Hrynchak, M. and Hayden, M.R. and Gibson, W.T.
DOI: 10.1111/cge.12633
2016

Pridopidine activates neuroprotective pathways impaired in Huntington Disease
Human Molecular Genetics
Geva, M. and Kusko, R. and Soares, H. and Fowler, K.D. and Birnberg, T. and Barash, S. and Merenlender-Wagner, A. and Fine, T. and Lysaght, A. and Weiner, B. and Cha, Y. and Kolitz, S. and Towfic, F. and Orbach, A. and Laufer, R. and Zeskind, B. and Grossman, I. and Hayden, M.R.
DOI: 10.1093/hmg/ddw238
2016

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD
Human Molecular Genetics
Riechers, S.-P. and Butland, S. and Deng, Y. and Skotte, N. and Ehrnhoefer, D.E. and Russ, J. and Laine, J. and Laroche, M. and Pouladi, M.A. and Wanker, E.E. and Hayden, M.R. and Graham, R.K.
DOI: 10.1093/hmg/ddw036
2016

Association of a multi-SNP signature with response to copaxone (Glatiramer Acetate) in a subset of patients and in multiple RRMS patient cohorts
Multiple Sclerosis Journal
Ross, C. and Towfic, F. and Shankar, J. and Laifenfeld, D. and Davies, M. and Thoma, M. and Zeskind, B. and Knappertz, V. and Grossman, I. and Hayden, M. R.
2016

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers
Movement Disorders
Sturrock, A. and Laule, C. and Wyper, K. and Milner, R.A. and Decolongon, J. and Santos, R.D. and Coleman, A.J. and Carter, K. and Creighton, S. and Bechtel, N. and Bohlen, S. and Reilmann, R. and Johnson, H.J. and Hayden, M.R. and Tabrizi, S.J. and Mackay, A.L. and Leavitt, B.R.
DOI: 10.1002/mds.26118
2015

Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1
Diabetes
Kaur, A. and Patankar, J.V. and De Haan, W. and Ruddle, P. and Wijesekara, N. and Groen, A.K. and Verchere, C.B. and Singaraja, R.R. and Hayden, M.R.
DOI: 10.2337/db14-0716
2015

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy
Therapeutic Drug Monitoring
Shaw, K. and Amstutz, U. and Kim, R.B. and Lesko, L.J. and Turgeon, J. and Michaud, V. and Hwang, S. and Ito, S. and Ross, C. and Carleton, B.C. and Hayden, M.R. and Hosking, M. and Virani, S. and MacLeod, S. and Rassekh, R. and Smith, A. and Brunham, L. and Shear, N.H. and Koren, G. and Liu, G. and Rieder, M.J. and Kim, R. and Maher, M. and Flockhart, D. and Lesko, L. and Rhoades, J.
DOI: 10.1097/FTD.0000000000000192
2015

Autophagy in Huntington disease and huntingtin in autophagy
Trends in Neurosciences
Martin, D.D.O. and Ladha, S. and Ehrnhoefer, D.E. and Hayden, M.R.
DOI: 10.1016/j.tins.2014.09.003
2015

A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Nature Genetics
Aminkeng, F. and Bhavsar, A.P. and Visscher, H. and Rassekh, S.R. and Li, Y. and Lee, J.W. and Brunham, L.R. and Caron, H.N. and Van Dalen, E.C. and Kremer, L.C. and Van Der Pal, H.J. and Amstutz, U. and Rieder, M.J. and Bernstein, D. and Carleton, B.C. and Hayden, M.R. and Ross, C.J.D.
DOI: 10.1038/ng.3374
2015

Loss-of-function mutations in ABCA1 and enhanced ß-cell secretory capacity in young adults. diabetes 2015;64:193-199
Diabetes
Patankar, J.V. and Brunham, L.R. and Hayden, M.R.
DOI: 10.2337/db15-0518
2015

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease
Neurobiology of Disease
Southwell, A.L. and Franciosi, S. and Villanueva, E.B. and Xie, Y. and Winter, L.A. and Veeraraghavan, J. and Jonason, A. and Felczak, B. and Zhang, W. and Kovalik, V. and Waltl, S. and Hall, G. and Pouladi, M.A. and Smith, E.S. and Bowers, W.J. and Zauderer, M. and Hayden, M.R.
DOI: 10.1016/j.nbd.2015.01.002
2015

Aberrant palmitoylation in Huntington disease
Biochemical Society Transactions
Sanders, S.S. and Hayden, M.R.
DOI: 10.1042/BST20140242
2015

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits
Human Molecular Genetics
Aharony, I. and Ehrnhoefer, D.E. and Shruster, A. and Qiu, X. and Franciosi, S. and Hayden, M.R. and Offen, D.
DOI: 10.1093/hmg/ddv023
2015

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice
Neurobiology of Disease
Wong, B.K.Y. and Ehrnhoefer, D.E. and Graham, R.K. and Martin, D.D.O. and Ladha, S. and Uribe, V. and Stanek, L.M. and Franciosi, S. and Qiu, X. and Deng, Y. and Kovalik, V. and Zhang, W. and Pouladi, M.A. and Shihabuddin, L.S. and Hayden, M.R.
DOI: 10.1016/j.nbd.2014.12.030
2015

Gene expression studies of a human monocyte cell line identify dissimilarities between differently manufactured glatiramoids
Scientific Reports
Kolitz, S. and Hasson, T. and Towfic, F. and Funt, J.M. and Bakshi, S. and Fowler, K.D. and Laifenfeld, D. and Grinspan, A. and Artyomov, M.N. and Birnberg, T. and Schwartz, R. and Komlosh, A. and Hayardeny, L. and Ladkani, D. and Hayden, M.R. and Zeskind, B. and Grossman, I.
DOI: 10.1038/srep10191
2015

Direct intracerebral delivery of a miR-33 antisense oligonucelotide into mouse brain increases brain ABCA1 expression
Neuroscience Letters
Jan, A. and Karasinska, J.M. and Kang, M.H. and de Haan, W. and Ruddle, P. and Kaur, A. and Connolly, C. and Leavitt, B.R. and Sorensen, P.H. and Hayden, M.R.
DOI: 10.1016/j.neulet.2015.05.007
2015

Human genetics of HDL: Insight into particle metabolism and function
Progress in Lipid Research
Brunham, L.R. and Hayden, M.R.
DOI: 10.1016/j.plipres.2015.01.001
2015

Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides
ACS Chemical Biology
?stergaard, M.E. and Thomas, G. and Koller, E. and Southwell, A.L. and Hayden, M.R. and Seth, P.P.
DOI: 10.1021/cb500880f
2015

A new mutation for Huntington disease following maternal transmission of an intermediate allele
European Journal of Medical Genetics
Semaka, A. and Kay, C. and Belfroid, R.D.M. and Bijlsma, E.K. and Losekoot, M. and van Langen, I.M. and van Maarle, M.C. and Oosterloo, M. and Hayden, M.R. and van Belzen, M.J.
DOI: 10.1016/j.ejmg.2014.11.005
2015

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression
Scientific Reports
Southwell, A.L. and Smith, S.E.P. and Davis, T.R. and Caron, N.S. and Villanueva, E.B. and Xie, Y. and Collins, J.A. and Li Ye, M. and Sturrock, A. and Leavitt, B.R. and Schrum, A.G. and Hayden, M.R.
DOI: 10.1038/srep12166
2015

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity
Genome Research
Stroedicke, M. and Bounab, Y. and Strempel, N. and Klockmeier, K. and Yigit, S. and Friedrich, R.P. and Chaurasia, G. and Li, S. and Hesse, F. and Riechers, S.-P. and Russ, J. and Nicoletti, C. and Boeddrich, A. and Wiglenda, T. and Haenig, C. and Schnoegl, S. and Fournier, D. and Graham, R.K. and Hayden, M.R. and Sigrist, S. and Bates, G.P. and Priller, J. and Andrade-Navarro, M.A. and Futschik, M.E. and Wanker, E.E.
DOI: 10.1101/gr.182444.114
2015

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children
Pharmacogenomics
Visscher, H. and Rassekh, S.R. and Sandor, G.S. and Caron, H.N. and Van Dalen, E.C. and Kremer, L.C. and Van Der Pal, H.J. and Rogers, P.C. and Rieder, M.J. and Carleton, B.C. and Hayden, M.R. and Ross, C.J.
DOI: 10.2217/pgs.15.61
2015

Corrigendum to "Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression'' [Neuroscience Letters 598 (2015) 66-72]
Neuroscience Letters
Jan, A. and Karasinska, J.M. and Kang, M.H. and Haan, W.D. and Ruddle, P. and Kaur, A. and Connolly, C. and Leavitt, B.R. and Sorensen, P.H. and Hayden, M.R.
DOI: 10.1016/j.neulet.2015.06.047
2015

A SNP in the HTT promoter alters NF-¿B binding and is a bidirectional genetic modifier of Huntington disease
Nature Neuroscience
Becanovic, K. and N?rrem?lle, A. and Neal, S.J. and Kay, C. and Collins, J.A. and Arenillas, D. and Lilja, T. and Gaudenzi, G. and Manoharan, S. and Doty, C.N. and Beck, J. and Lahiri, N. and Portales-Casamar, E. and Warby, S.C. and Connolly, C. and De Souza, R.A.G. and Tabrizi, S.J. and Hermanson, O. and Langbehn, D.R. and Hayden, M.R. and Wasserman, W.W. and Leavitt, B.R.
DOI: 10.1038/nn.4014
2015

Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration
Biochemical Society Transactions
Martin, D.D.O. and Hayden, M.R.
DOI: 10.1042/BST20140281
2015

Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease
Molecular Neurobiology
Ooi, J. and Hayden, M.R. and Pouladi, M.A.
DOI: 10.1007/s12035-014-8974-4
2015

Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development
Developmental Biology
Sanders, S.S. and Hou, J. and Sutton, L.M. and Garside, V.C. and Mui, K.K.N. and Singaraja, R.R. and Hayden, M.R. and Hoodless, P.A.
DOI: 10.1016/j.ydbio.2014.11.018
2015

Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in huntington disease patients of european ancestry
Molecular Therapy
Kay, C. and Collins, J.A. and Skotte, N.H. and Southwell, A.L. and Warby, S.C. and Caron, N.S. and Doty, C.N. and Nguyen, B. and Griguoli, A. and Ross, C.J. and Squitieri, F. and Hayden, M.R.
DOI: 10.1038/mt.2015.128
2015

Targeted next-generation sequencing to diagnose disorders of HDL cholesterol
Journal of Lipid Research
Sadananda, S.N. and Foo, J.N. and Toh, M.T. and Cermakova, L. and Trigueros-Motos, L. and Chan, T. and Liany, H. and Collins, J.A. and Gerami, S. and Singaraja, R.R. and Hayden, M.R. and Francis, G.A. and Frohlich, J. and Khor, C.C. and Brunham, L.R.
DOI: 10.1194/jlr.P058891
2015

Huntington disease
Nature Reviews Disease Primers
Bates, G.P. and Dorsey, R. and Gusella, J.F. and Hayden, M.R. and Kay, C. and Leavitt, B.R. and Nance, M. and Ross, C.A. and Scahill, R.I. and Wetzel, R. and Wild, E.J. and Tabrizi, S.J.
DOI: 10.1038/nrdp.2015.5
2015

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers
PLoS Computational Biology
Sanders, S.S. and Martin, D.D.O. and Butland, S.L. and Lavallée-Adam, M. and Calzolari, D. and Kay, C. and Yates, J.R. and Hayden, M.R.
DOI: 10.1371/journal.pcbi.1004405
2015

Clinical, biochemical, and molecular characterization of novel mutations in ABCA1 in families with tangier disease
JIMD Reports
DOI: 10.1007/8904_2014_348
2015

Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: Providing a therapeutic option for all Huntington disease patients
PLoS ONE
Skotte, N.H. and Southwell, A.L. and ?stergaard, M.E. and Carroll, J.B. and Warby, S.C. and Doty, C.N. and Petoukhov, E. and Vaid, K. and Kordasiewicz, H. and Watt, A.T. and Freier, S.M. and Hung, G. and Seth, P.P. and Bennett, C.F. and Swayze, E.E. and Hayden, M.R.
DOI: 10.1371/journal.pone.0107434
2014

Pharmacogenomic diversity in Singaporean populations and Europeans
Pharmacogenomics Journal
Brunham, L.R. and Chan, S.L. and Li, R. and Aminkeng, F. and Liu, X. and Saw, W.Y. and Ong, R.T.H. and Pillai, E.N. and Carleton, B.C. and Toh, D. and Tan, S.H. and Koo, S.H. and Lee, E.J.D. and Chia, K.S. and Ross, C.J.D. and Hayden, M.R. and Sung, C. and Teo, Y.Y.
DOI: 10.1038/tpj.2014.22
2014

Laquinimod reduces neuronal caspase-6 activation and axonal degeneration in vitro
Movement Disorders
Ehrnhoefer, D. E. and Tsang, M. Y. and Qiu, X. and Hayden, M. R.
2014

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans
Journal of Lipid Research
Singaraja, R.R. and Tietjen, I. and Hovingh, G.K. and Franchini, P.L. and Radomski, C. and Wong, K. and VanHeek, M. and Stylianou, I.M. and Lin, L. and Wang, L. and Mitnaul, L. and Hubbard, B. and Winther, M. and Mattice, M. and Legendre, A. and Sherrington, R. and Kastelein, J.J. and Akinsanya, K. and Plump, A. and Hayden, M.R.
DOI: 10.1194/jlr.M048710
2014

High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice
Journal of Lipid Research
Rinninger, F. and Heine, M. and Singaraja, R. and Hayden, M. and Brundert, M. and Ramakrishnan, R. and Heeren, J.
DOI: 10.1194/jlr.M048819
2014

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
Human Molecular Genetics
Mattis, V.B. and Tom, C. and Akimov, S. and Saeedian, J. and ?stergaard, M.E. and Southwell, A.L. and Doty, C.N. and Ornelas, L. and Sahabian, A. and Lenaeus, L. and Mandefro, B. and Sareen, D. and Arjomand, J. and Hayden, M.R. and Ross, C.A. and Svendsen, C.N.
DOI: 10.1093/hmg/ddv080
2014

Evidence-based genetic counselling implications for Huntington disease intermediate allele predictive test results
Clinical Genetics
Semaka, A. and Hayden, M.R.
DOI: 10.1111/cge.12324
2014

CODEINE-RELATED DEATHS IN ONTARIO, CANADA: THE ROLE OF PHARMACOGENETICS AND DRUG INTERACTIONS
Clinical Pharmacology & Therapeutics
Lam, J. and Woodall, K. and Solbeck, P. and Ross, C. J. and Carleton, B. C. and Hayden, M. R. and Koren, G. and Madadi, P.
2014

Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin
Human Molecular Genetics
Martin, D.D.O. and Heit, R.J. and Yap, M.C. and Davidson, M.W. and Hayden, M.R. and Berthiaume, L.G.
DOI: 10.1093/hmg/ddu027
2014

Comparing the biological impact of glatiramer acetate with the biological impact of a generic
PLoS ONE
Towfic, F. and Funt, J.M. and Fowler, K.D. and Bakshi, S. and Blaugrund, E. and Artyomov, M.N. and Hayden, M.R. and Ladkani, D. and Schwartz, R. and Zeskind, B.
DOI: 10.1371/journal.pone.0083757
2014

Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of huntington disease
PLoS ONE
Kolodziejczyk, K. and Parsons, M.P. and Southwell, A.L. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1371/journal.pone.0094562
2014

Personalized gene silencing therapeutics for Huntington disease
Clinical Genetics
Kay, C. and Skotte, N.H. and Southwell, A.L. and Hayden, M.R.
DOI: 10.1111/cge.12385
2014

Genetic markers of cisplatin-induced hearing loss in children
Clinical Pharmacology and Therapeutics
Carleton, B.C. and Ross, C.J. and Pussegoda, K. and Bhavsar, A.P. and Visscher, H. and Lee, J.W. and Brooks, B. and Rassekh, S.R. and Dubé, M.-P.P. and Hayden, M.R.
DOI: 10.1038/clpt.2014.92
2014

VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children
Pediatric Blood and Cancer
Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S.R. and Hosking, M. and Neville, K. and Leeder, J.S. and Hayden, M.R. and Ross, C.J. and Carleton, B.C.
DOI: 10.1002/pbc.24932
2014

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin
Human Molecular Genetics
Ehrnhoefer, D.E. and Skotte, N.H. and Ladha, S. and Nguyen, Y.T.N. and Qiu, X. and Deng, Y. and Huynh, K.T. and Engemann, S. and Nielsen, S.M. and Becanovic, K. and Leavitt, B.R. and Hasholt, L. and Hayden, M.R.
DOI: 10.1093/hmg/ddt458
2014

Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritis
Journal of Neuroimmunology
Pitarokoili, K. and Ambrosius, B. and Schrewe, L. and Hayardeny, L. and Hayden, M. and Gold, R.
DOI: 10.1016/j.jneuroim.2014.06.012
2014

Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent
Pharmacogenomics Journal
Aminkeng, F. and Ross, C.J.D. and Rassekh, S.R. and Brunham, L.R. and Sistonen, J. and Dube, M.-P. and Ibrahim, M. and Nyambo, T.B. and Omar, S.A. and Froment, A. and Bodo, J.-M. and Tishkoff, S. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1038/tpj.2013.13
2014

Hepatic ABCA1 expression improves ß-cell function and glucose tolerance
Diabetes
De Haan, W. and Karasinska, J.M. and Ruddle, P. and Hayden, M.R.
DOI: 10.2337/db14-0548
2014

ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity
Journal of Lipid Research
De Haan, W. and Bhattacharjee, A. and Ruddle, P. and Kang, M.H. and Hayden, M.R.
DOI: 10.1194/jlr.M045294
2014

Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families
Clinical Genetics
Bochem, A.E. and van Capelleveen, J.C. and Dallinga-Thie, G.M. and Schimmel, A.W.M. and Motazacker, M.M. and Tietjen, I. and Singaraja, R.R. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.G. and Hovingh, G.K.
DOI: 10.1111/cge.12201
2014

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides
Molecular Therapy
Southwell, A.L. and Skotte, N.H. and Kordasiewicz, H.B. and ?stergaard, M.E. and Watt, A.T. and Carroll, J.B. and Doty, C.N. and Villanueva, E.B. and Petoukhov, E. and Vaid, K. and Xie, Y. and Freier, S.M. and Swayze, E.E. and Seth, P.P. and Bennett, C.F. and Hayden, M.R.
DOI: 10.1038/mt.2014.153
2014

A novel inhibitor of Caspase-6 provides protection against mutant huntingtin toxicity
Journal of Molecular Neuroscience
Aharony, I. and Ehrnhoefer, D. and Shruster, A. and Franciosi, S. and Hayden, M. R. and Offen, D.
2014

Use of genetic technologies to compare medicines
Clinical Genetics
Kolitz, S.E. and Towfic, F. and Grossman, I. and Hayden, M.R. and Zeskind, B.
DOI: 10.1111/cge.12462
2014

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: Implications for a role in the pathogenesis of Huntington's disease
Human Molecular Genetics
Butland, S.L. and Sanders, S.S. and Schmidt, M.E. and Riechers, S.-P. and Lin, D.T.S. and Martin, D.D.O. and Vaid, K. and Graham, R.K. and Singaraja, R.R. and Wanker, E.E. and Conibear, E. and Hayden, M.R.
DOI: 10.1093/hmg/ddu137
2014

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity
Clinical Pharmacology and Therapeutics
Carleton, B.C. and Ross, C.J. and Bhavsar, A.P. and Amstutz, U. and Pussegoda, K. and Visscher, H. and Lee, J.W. and Brooks, B. and Rassekh, S.R. and Dubé, M.-P. and Hayden, M.R.
DOI: 10.1038/clpt.2013.219
2014

Examining conditional caspase-6 deficiency as a therapeutic in Huntington's disease
Movement Disorders
Ladha, S. and Wong, B. K. Y. and Hayden, M. R.
2014

Response to "Evaluation of Pharmacogenetic Markers to Predict the Risk of Cisplatin-Induced Ototoxicity"
Clinical Pharmacology and Therapeutics
Carleton, B.C. and Ross, C.J. and Bhavsar, A.P. and Lee, J.W. and Visscher, H. and Rassekh, S.R. and Hayden, M.R.
DOI: 10.1038/clpt.2014.90
2014

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
Proceedings of the National Academy of Sciences of the United States of America
Rotblat, B. and Southwell, A.L. and Ehrnhoefer, D.E. and Skotte, N.H. and Metzler, M. and Franciosi, S. and Leprivier, G. and Somasekharan, S.P. and Barokas, A. and Deng, Y. and Tang, T. and Mathers, J. and Cetinbas, N. and Daugaard, M. and Kwok, B. and Li, L. and Carnie, C.J. and Fink, D. and Nitsch, R. and Galpin, J.D. and Ahern, C.A. and Melino, G. and Penninger, J.M. and Hayden, M.R. and Sorensen, P.H.
DOI: 10.1073/pnas.1314421111
2014

Elevated cytokine release in microglia from Huntington's disease mice is reversed by laquinimod
Movement Disorders
Leavitt, B. R. and Connolly, C. and Wagner, P. K. and Hayardeny, L. and Hayden, M. R.
2014

Bidirectional control of Postsynaptic Density-95 (PSD-95) clustering by Huntingtin
Journal of Biological Chemistry
Parsons, M.P. and Kang, R. and Buren, C. and Dau, A. and Southwell, A.L. and Doty, C.N. and Sanders, S.S. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1074/jbc.M113.513945
2014

The emerging era of pharmacogenomics: Current successes, future potential, and challenges
Clinical Genetics
Lee, J.W. and Aminkeng, F. and Bhavsar, A.P. and Shaw, K. and Carleton, B.C. and Hayden, M.R. and Ross, C.J.D.
DOI: 10.1111/cge.12392
2014

Public perceptions of pharmacogenetics
Pediatrics
Zhang, S.C. and Bruce, C. and Hayden, M. and Rieder, M.J.
DOI: 10.1542/peds.2013-1416
2014

Multisource ascertainment of Huntington disease in Canada: Prevalence and population at risk
Movement Disorders
Fisher, E.R. and Hayden, M.R.
DOI: 10.1002/mds.25717
2014

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice
Molecular Neurobiology
Lopes, C. and Ribeiro, M. and Duarte, A.I. and Humbert, S. and Saudou, F. and Pereira De Almeida, L. and Hayden, M. and Rego, A.C.
DOI: 10.1007/s12035-013-8585-5
2014

Identification of binding sites in huntingtin for the huntingtin interacting proteins HIP14 and HIP14L
PLoS ONE
Sanders, S.S. and Mui, K.K.N. and Sutton, L.M. and Hayden, M.R.
DOI: 10.1371/journal.pone.0090669
2014

Development of a broad-based ADME panel for use in pharmacogenomic studies
Pharmacogenomics
Brown, A.M.K. and Renaud, Y. and Ross, C. and Hansen, M. and Mongrain, I. and Valois, D. and Carleton, B.C. and Hayden, M.R. and Dubé, M.-P. and Tardif, J.-C. and Phillips, M.S.
DOI: 10.2217/pgs.14.81
2014

Codeine-related deaths: The role of pharmacogenetics and drug interactions
Forensic Science International
Lam, J. and Woodall, K.L. and Solbeck, P. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G. and Madadi, P.
DOI: 10.1016/j.forsciint.2014.03.018
2014

Genetic Variation Does Not Influence Renal Function Following Pediatric Kidney Transplantation Receiving Tacrolimus
Therapeutic Drug Monitoring
Gijsen, Vmgj and Hesselink, D. A. and Ross, C. and Dube, M. P. and van Schaik, R. H. N. and Van Gelder, T. and Cransberg, K. and t Jong, G. W. and Feroz-Zada, Y. and Nasserinejad, K. and van Rosmalen, J. and Hebert, D. and Grant, D. and Verjee, Z. and Carlton, B. and Hayden, M. R. and Tibboel, D. and de Wildt, S. N. and Koren, G.
2013

Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children
Clinical Pharmacology and Therapeutics
Pussegoda, K. and Ross, C.J. and Visscher, H. and Yazdanpanah, M. and Brooks, B. and Rassekh, S.R. and Zada, Y.F. and Dubé, M.-P. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1038/clpt.2013.80
2013

Recommendations for the predictive genetic test in Huntington's disease
Clinical Genetics
Macleod, R. and Tibben, A. and Frontali, M. and Evers-Kiebooms, G. and Jones, A. and Martinez-Descales, A. and Roos, R. and Bijlsma, E. and Blinkenberg, E. and Bombard, Y. and Borry, P. and Craufurd, D. and Davis, M. and De Die-Smulders, C. and Downing, C. and Dürr, A. and Garcia Barcina, M. and Glew, R. and Heiberg, A. and Heydon, F. and Hoffman-Zacharsk, D. and Hösterey Ugander, U. and José Trujillo Tiebas, M. and Krysa, W. and Liebaers, I. and Lohkamp, C. and Mandich, P. and Mariotti, C. and De Schepper, B. and Di Maria, E. and Nemeth, A. and Quarrell, O. and Ribaï, P. and Semaka, A. and Seneca, S. and Sequeiros, J. and Squitieri, F. and Sulek, A. and Van Der Meer, L. and Verellen-Dumoulin, C. and De Wert, G. and Delatycki, M. and Guttman, M. and Hayden, M. and Nance, M. and Richards, F. and Vetter, L.
DOI: 10.1111/j.1399-0004.2012.01900.x
2013

Pharmacogenomics of vincristine-induced neurotoxicity in pediatric cancer patients
Faseb Journal
Amstutz, U. and Loo, T. T. and Gylling, H. M. and Rassekh, R. and Hukin, J. and Zada, Y. F. and Dube, M. P. and Brown, A. M. and Phillips, M. S. and Hayden, M. R. and Ross, C. J. and Carleton, B. C.
2013

Pharmacogenomic investigation of adverse drug reactions (ADRS): The ADR prioritization tool, APT
Journal of Population Therapeutics and Clinical Pharmacology
Shaw, K. and Amstutz, U. and Castro-Pastrana, L. and Loo, T.T. and Ross, C.J. and Ito, S. and Rieder, M.J. and Maher, M. and MacLeod, S. and Koren, G. and Hayden, M.R. and Carleton, B.C.
2013

Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease
Human Molecular Genetics
Sutton, L.M. and Sanders, S.S. and Butland, S.L. and Singaraja, R.R. and Franciosi, S. and Southwell, A.L. and Doty, C.N. and Schmidt, M.E. and Mui, K.K. and Kovalik, V. and Young, F.B. and Zhang, W. and Hayden, M.R.
DOI: 10.1093/hmg/dds441
2013

Cancer pharmacogenomics in children: Research initiatives and progress to date
Pediatric Drugs
Rassekh, S.R. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1007/s40272-013-0021-9
2013

Antisense oligonucleotide-mediated correction of transcriptional dysregulation is correlated with behavioral benefits in the YAC128 mouse model of huntington’s disease
Journal of Huntington's Disease
Stanek, L.M. and Yang, W. and Angus, S. and Sardi, P.S. and Hayden, M.R. and Hung, G.H. and Frank Bennett, C. and Cheng, S.H. and Shihabuddin, L.S.
DOI: 10.3233/JHD-130057
2013

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy
Journal of Population Therapeutics and Clinical Pharmacology
Madadi, P. and Amstutz, U. and Rieder, M. and Ito, S. and Fung, V. and Hwang, S. and Turgeon, J. and Michaud, V. and Koren, G. and Carleton, B.C. and Hayden, M.R. and Ross, C.J. and MacLeod, S. and Rassekh, R. and Lauder, G. and Smith, A. and Brunham, L. and Shear, N.H. and Liu, G. and Kim, R. and Maher, M. and Flockhart, D.
2013

Causes of Variability in Deterioration of Renal Function Among Pediatric Liver Transplant Recipients Receiving Tacrolimus
Therapeutic Drug Monitoring
Gijsen, Vmgj and Hesselink, D. A. and t Jong, G. W. and van Schaik, R. H. N. and Ng, V. and Grant, D. and FerozZada, Y. and Nasserinejad, K. and van Rosmalen, J. and Verjee, Z. and Ross, C. and Carleton, B. and Hayden, M. R. and Tibboel, D. and Dube, M. P. and Koren, G. and de Wildt, S. N.
2013

CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease
Journal of Medical Genetics
Semaka, A. and Kay, C. and Doty, C. and Collins, J.A. and Bijlsma, E.K. and Richards, F. and Goldberg, Y.P. and Hayden, M.R.
DOI: 10.1136/jmedgenet-2013-101796
2013

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models
Nature Medicine
Marco, S. and Giralt, A. and Petrovic, M.M. and Pouladi, M.A. and Martínez-Turrillas, R. and Martínez-Hernández, J. and Kaltenbach, L.S. and Torres-Peraza, J. and Graham, R.K. and Watanabe, M. and Luján, R. and Nakanishi, N. and Lipton, S.A. and Lo, D.C. and Hayden, M.R. and Alberch, J. and Wesseling, J.F. and Pérez-Otaño, I.
DOI: 10.1038/nm.3246
2013

Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers
Therapeutic Drug Monitoring
Lam, J. and Kelly, L. and Matok, I. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Madadi, P. and Koren, G.
DOI: 10.1097/FTD.0b013e318288f158
2013

Mutations In ABCA8 Result In HDL Deficiency And Cholesterol Efflux Defects
Circulation Research
Singaraja, R. and van Capelleveen, J. and Hovingh, K. and Zhang, L. H. and Dallinga-Thie, G. and Tietjen, I. and Wong, K. and Kastelein, J. J. and Hayden, M. R.
2013

Memory and synaptic deficits in Hip14/DHHC17 knockout mice
Proceedings of the National Academy of Sciences of the United States of America
Milnerwood, A.J. and Parsons, M.P. and Young, F.B. and Singaraja, R.R. and Franciosi, S. and Volta, M. and Bergeron, S. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1073/pnas.1222384110
2013

Developing a comprehensive, effective patient-friendly website to enhance decision making in predictive testing for Huntington disease
Genetics in Medicine
Virani, A.K.H. and Creighton, S.M. and Hayden, M.R.
DOI: 10.1038/gim.2012.149
2013

An Education Based Intervention Study for Reducing CNS Depression among Neonates Exposed to Codeine through Breast Milk
Birth Defects Research Part a-Clinical and Molecular Teratology
Chaudhry, S. and Kelly, L. E. and Rieder, M. and T'Jong, G. and Morretti, M. and Lausman, A. and Ross, C. and Berger, H. and Carleton, B. and Hayden, M. R. and Madadi, P. and Koren, G.
2013

ABCA1 influences neuroinflammation and neuronal death
Neurobiology of Disease
Karasinska, J.M. and de Haan, W. and Franciosi, S. and Ruddle, P. and Fan, J. and Kruit, J.K. and Stukas, S. and Lütjohann, D. and Gutmann, D.H. and Wellington, C.L. and Hayden, M.R.
DOI: 10.1016/j.nbd.2013.01.018
2013

A systematic review and meta-analysis of clinical variables used in Huntington disease research
Movement Disorders
Franciosi, S. and Shim, Y. and Lau, M. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1002/mds.25663
2013

The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-chaperone Activity of SGT1 to Subvert Immunity
PLoS Pathogens
Bhavsar, A.P. and Brown, N.F. and Stoepel, J. and Wiermer, M. and Martin, D.D.O. and Hsu, K.J. and Imami, K. and Ross, C.J. and Hayden, M.R. and Foster, L.J. and Li, X. and Hieter, P. and Finlay, B.B.
DOI: 10.1371/journal.ppat.1003518
2013

From mutation identification to therapy: Discovery and origins of the first approved gene therapy in the western world
Human Gene Therapy
Kastelein, J.J.P. and Ross, C.J.D. and Hayden, M.R.
DOI: 10.1089/hum.2013.063
2013

The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans
Circulation: Cardiovascular Genetics
Singaraja, R.R. and Sivapalaratnam, S. and Hovingh, K. and Dubé, M.-P. and Castro-Perez, J. and Collins, H.L. and Adelman, S.J. and Riwanto, M. and Manz, J. and Hubbard, B. and Tietjen, I. and Wong, K. and Mitnaul, L.J. and Van Heek, M. and Lin, L. and Roddy, T.A. and McEwen, J. and Dallinge-Thie, G. and Van Vark-Van Der Zee, L. and Verwoert, G. and Winther, M. and Van Duijn, C. and Hofman, A. and Trip, M.D. and Marais, A.D. and Asztalos, B. and Landmesser, U. and Sijbrands, E. and Kastelein, J.J. and Hayden, M.R.
DOI: 10.1161/CIRCGENETICS.111.962613
2013

Pharmacogenetics of warfarin safety and effectiveness in children
Faseb Journal
Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S. R. and Dube, M. P. and Hayden, M. R. and Ross, C. J. and Carleton, B. C.
2013

An investigation of morphine-to-codeine metabolic ratios in postmortem blood, drug interactions, and cytochrome P450 2D6 (CYP2D6) genotype
Faseb Journal
Lam, J. and Woodall, K. and Solbeck, P. and Ross, C. J. D. and Carleton, B. and Hayden, M. R. and Koren, G. and Madadi, P.
2013

A fully humanized transgenic mouse model of Huntington disease
Human Molecular Genetics
Southwell, A.L. and Warby, S.C. and Carroll, J.B. and Doty, C.N. and Skotte, N.H. and Zhang, W. and Villanueva, E.B. and Kovalik, V. and Xie, Y. and Pouladi, M.A. and Collins, J.A. and Yang, X.W. and Franciosi, S. and Hayden, M.R.
DOI: 10.1093/hmg/dds397
2013

Tracking brain palmitoylation change: Predominance of glial change in a mouse model of Huntington's disease
Chemistry and Biology
Wan, J. and Savas, J.N. and Roth, A.F. and Sanders, S.S. and Singaraja, R.R. and Hayden, M.R. and Yates III, J.R. and Davis, N.G.
DOI: 10.1016/j.chembiol.2013.09.018
2013

Special new feature in Clinical Genetics
Clinical Genetics
Hayden, M.R.
DOI: 10.1111/cge.12067
2013

Sirtuin modulators alter mitochondrial function in in vitro and in vivo Huntington's disease models
European Journal of Clinical Investigation
Naia, L. and Rosenstock, T. R. and Oliveira-Sousa, S. I. and Caldeira, G. L. and Laco, M. N. and Hayden, M. R. and Rego, A. C.
2013

Predicting Anthracycline-induced Cardiotoxicity in Children - Genome-Wide Association Study
Faseb Journal
Aminkeng, F. and Ross, C. J. D. and Rassekh, R. S. and Brunham, L. R. and Weissman, C. and Dube, M. P. and Visscher, H. and Rieder, M. J. and Carleton, B. C. and Hayden, M. R.
2013

Life-threatening adverse events following therapeutic opioid administration in adults: Is pharmacogenetic analysis useful?
Pain Research and Management
Madadi, P. and Sistonen, J. and Silverman, G. and Gladdy, R. and Ross, C.J. and Carleton, B.C. and Carvalho, J.C. and Hayden, M.R. and Koren, G.
DOI: 10.1155/2013/518012
2013

Investigating Genetic and Clinical Sources of Variability in Predicting Deterioration of Renal Function Among Pediatric Heart Transplant Recipients Receiving Tacrolimus
Therapeutic Drug Monitoring
Gijsen, Vmgj and Dube, M. P. and Hesselink, D. A. and Ross, C. and Mital, S. and t Jong, G. W. and van Schaik, R. H. N. and Dalinghaus, M. and Grant, D. and Zada, Y. F. and Nasserinejad, K. and van Rosmalen, J. and Verjee, Z. and Carleton, B. and Hayden, M. R. and Tibboel, D. and Koren, G. and de Wildt, S. N.
2013

High frequency of intermediate alleles on huntington disease-associated haplotypes in British Columbia's general population
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Semaka, A. and Kay, C. and Doty, C.N. and Collins, J.A. and Tam, N. and Hayden, M.R.
DOI: 10.1002/ajmg.b.32193
2013

Erratum: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy (Nature Genetics (2009) 41 (1345-1349))
Nature Genetics
Ross, C.J.D. and Katzov-Eckert, H. and Dubé, M.-P. and Brooks, B. and Rassekh, S.R. and Barhdadi, A. and Feroz-Zada, Y. and Visscher, H. and Brown, A.M.K. and Rieder, M.J. and Rogers, P.C. and Phillips, M.S. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1038/ng.0513-578
2013

Choosing an animal model for the study of Huntington's disease
Nature Reviews Neuroscience
Pouladi, M.A. and Morton, A.J. and Hayden, M.R.
DOI: 10.1038/nrn3570
2013

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset
Neurogenetics
Ramos, E.M. and Latourelle, J.C. and Gillis, T. and Mysore, J.S. and Squitieri, F. and Di Pardo, A. and Di Donato, S. and Gellera, C. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Gusella, J.F. and Lee, J.-M. and Alonso, I. and Sequeiros, J. and Myers, R.H. and MacDonald, M.E.
DOI: 10.1007/s10048-013-0364-y
2013

A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk
PLoS ONE
Kelly, L.E. and Chaudhry, S.A. and Rieder, M.J. and 't Jong, G. and Moretti, M.E. and Lausman, A. and Ross, C. and Berger, H. and Carleton, B. and Hayden, M.R. and Madadi, P. and Koren, G.
DOI: 10.1371/journal.pone.0070073
2013

"Grasping the grey": Patient understanding and interpretation of an intermediate allele predictive test result for huntington disease
Journal of Genetic Counseling
Semaka, A. and Balneaves, L.G. and Hayden, M.R.
DOI: 10.1007/s10897-012-9533-7
2013

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Nucleic Acids Research
?stergaard, M.E. and Southwell, A.L. and Kordasiewicz, H. and Watt, A.T. and Skotte, N.H. and Doty, C.N. and Vaid, K. and Villanueva, E.B. and Swayze, E.E. and Bennett, C.F. and Hayden, M.R. and Seth, P.P.
DOI: 10.1093/nar/gkt725
2013

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6
Cell Death and Differentiation
Van Raam, B.J. and Ehrnhoefer, D.E. and Hayden, M.R. and Salvesen, G.S.
DOI: 10.1038/cdd.2012.98
2013

Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes
European Journal of Human Genetics
Baine, F.K. and Kay, C. and Ketelaar, M.E. and Collins, J.A. and Semaka, A. and Doty, C.N. and Krause, A. and Jacquie Greenberg, L. and Hayden, M.R.
DOI: 10.1038/ejhg.2013.2
2013

HLA-A*31:01 and HLA-B*15:02 as genetic markers for carbamazepine hypersensitivity in children
Clinical Pharmacology and Therapeutics
Amstutz, U. and Ross, C.J.D. and Castro-Pastrana, L.I. and Rieder, M.J. and Shear, N.H. and Hayden, M.R. and Carleton, B.C.
DOI: 10.1038/clpt.2013.55
2013

De novo huntington disease caused by 26-44 CAG repeat expansion on a low-risk haplotype
Neurology
Houge, G. and Bruland, O. and Bj?rnevoll, I. and Hayden, M.R. and Semaka, A.
DOI: 10.1212/WNL.0b013e3182a4a4af
2013

When access is an issue: Exploring barriers to predictive testing for Huntington disease in British Columbia, Canada
European Journal of Human Genetics
Hawkins, A.K. and Creighton, S. and Hayden, M.R.
DOI: 10.1038/ejhg.2012.147
2013

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children
Pediatric Blood and Cancer
Visscher, H. and Ross, C.J.D. and Rassekh, S.R. and Sandor, G.S.S. and Caron, H.N. and van Dalen, E.C. and Kremer, L.C. and van der Pal, H.J. and Rogers, P.C. and Rieder, M.J. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1002/pbc.24505
2013

Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145
Arteriosclerosis, Thrombosis, and Vascular Biology
Kang, M.H. and Zhang, L.-H. and Wijesekara, N. and De Haan, W. and Butland, S. and Bhattacharjee, A. and Hayden, M.R.
DOI: 10.1161/ATVBAHA.113.302004
2013

Providing predictive testing for Huntington disease via telehealth: Results of a pilot study in British Columbia, Canada
Clinical Genetics
Hawkins, A. and Creighton, S. and Ho, A. and Mcmanus, B. and Hayden, M.
DOI: 10.1111/cge.12033
2013

Hunting human disease genes: Lessons from the past, challenges for the future
Human Genetics
Brunham, L.R. and Hayden, M.R.
DOI: 10.1007/s00439-013-1286-3
2013

8OHdG as a marker for Huntington disease progression
Neurobiology of Disease
Long, J.D. and Matson, W.R. and Juhl, A.R. and Leavitt, B.R. and Paulsen, J.S. and Wassink, T. and Cross, S. and Doucette, N. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E.A. and Beglinger, L.J. and Chiu, E. and Yastrubetskaya, O. and Preston, J. and Goh, A. and Fonseka, C. and Ronsisvalle, L. and Chua, P. and Komiti, A. and Raymond, L. and Santos, R.D. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Shpritz, B. and Welsh, C. and Mallonee, W.M. and Suter, G. and Addison, J. and Samii, A. and Macaraeg, A. and Jones, R. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and Goodman, A. and Swain, R. and Dipietro, A. and McCusker, E. and Griffith, J. and Loy, C. and Gunn, D. and Stewart, L. and Landwehrmeyer, B.G. and Orth, M. and Sü?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Karmalkar, I. and Perlman, S. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Kang, G. and Warner, T. and Burrows, M. and Novak, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Price, K. and Hunt, S. and Marshall, F. and Chesire, A. and Wodarski, M. and Hickey, C. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Panegyres, P. and Vuletich, E. and Andrew, S. and Zombor, R. and Perlmutter, J. and Barton, S. and Schmidt, A. and Miedzybrodzka, Z. and Simpson, S.A. and Rae, D. and D'alessandro, M. and Craufurd, D. and Fullam, R. and Howard, E. and Mazzoni, P. and Marder, K. and Wasserman, P. and Kumar, R. and Erickson, D. and Wheelock, V. and Tempkin, T. and Mans, N. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and de Yebenes, J.G. and Garde, M.B. and Fatas, M. and Martinez-Descales, A. and Martin, W. and King, P. and Sran, S. and Ahmed, A. and Rao, S. and Reece, C. and Zimbelman, J. and Bea, A. and Newman, E. and Bura, A. and Paulsen, J. and Johnson, H. and Smith, M.M. and Williams, J. and Beglinger, L. and Mills, J. and Aylward, E. and Biglan, K. and Macdonald, M. and Nance, M. and Erwin, C. and Hayden, M. and Didonato, S. and Evans, K. and Peterson, A. and Borowsky, B. and Juhl, A. and Weir, D. and Vonsattell, J.P. and Moskowitz, C. and Leserman, A. and Schaul, L. and Vik, S. and Harrington, D. and Castillo, G. and Morison, J. and Reed, J. and Diaz, M. and Dobbins, I. and Hershey, T. and Foster, E. and Moore, D. and Westervelt, H. and Davis, J. and Tremont, G. and Moser, D.J. and Rowe, K. and Theriault, D. and Gehl, C. and Matheson, K. and Siedlecki, K. and Van Walsem, M. and Bonner, S. and Elias, G. and Faust, M. and Borowski, B. and Carlozzi, N. and Duff, K. and Georgiou-Karistianis, N. and Stout, J. and Lange, H. and Papp, K. and Ro, E. and Clark, L.A. and Downing, N. and Laing, J. and Rees, K. and Ready, R. and Vaccarino, A. and Farias, S. and Gusella, J. and Myers, R. and Juhl, A. and Wang, K. and Ross, C. and Pierson, R. and Jones, K. and Marietta, J. and McDowell, W. and Harris, G. and Kim, E.Y. and Ashburner, J. and Potkin, S. and Toga, A. and Axelson, E. and Miller, M. and Reading, S. and Beg, M.F. and Magnotta, V.A. and Helmer, K. and Lim, K. and Lowe, M. and Mori, S. and Song, A. and Turner, J. and Beall, E. and Koenig, K. and Phillips, M. and Bryant, A. and Corey-Bloom, J. and Reilmann, R. and Unds, Z. and Fiedorowicz, J. and Robinson, R. and Ruggle, A. and Liu, D. and Anderson, K. and Groves, M. and Rickards, H. and van Duijn, E. and Antonijevic, I. and Giuliano, J. and Lu, W. and Lourens, S. and Zhang, Y. and Kimble, M. and Thumma, K. and Waterman, E. and Hinkel, J. and Schaul, L. and Hughes, L. and Connell, R.J. and Pease, K. and Rogers, B. and Smith, J. and Wu, S. and Zschiegner, R. and Carney, E. and McKirgan, B. and Scully, M. and Wyse, R. and Bockholt, J. and Werling-Witkoske, C. and Anderson, K. and Rapp, J. and Dudler, A. and Schumacher, J. and Thompson, S. and Davis, L. and Henneberry, M. and Ennis, G. and Blanchard, S. and Montross, K. and Danzer, P.
DOI: 10.1016/j.nbd.2012.02.012
2012

What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration
Clinical Genetics
Ketelaar, M.E. and Hofstra, R.M.W. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.2011.01795.x
2012

Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers
Clinical Pharmacology and Therapeutics
Sistonen, J. and Madadi, P. and Ross, C.J. and Yazdanpanah, M. and Lee, J.W. and Landsmeer, M.L.A. and Nauta, M. and Carleton, B.C. and Koren, G. and Hayden, M.R.
DOI: 10.1038/clpt.2011.280
2012

Population stratiWcation may bias analysis of PGC-1a as a modiWer of age at Huntington disease motor onset
Human Genetics
Ramos, E.M. and Latourelle, J.C. and Lee, J.-H. and Gillis, T. and Mysore, J.S. and Squitieri, F. and Di Pardo, A. and Di Donato, S. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Marder, K. and Gusella, J.F. and Lee, J.-M. and Alonso, I. and Sequeiros, J. and Myers, R.H. and MacDonald, M.E.
DOI: 10.1007/s00439-012-1205-z
2012

Caspase-6-resistant mutant huntingtin does not rescue the toxic effects of caspase-cleavable mutant huntingtin in vivo
Journal of Huntington's Disease
Graham, R.K. and Deng, Y. and Pouladi, M.A. and Vaid, K. and Ehrnhoefer, D. and Southwell, A.L. and Bissada, N. and Franciosi, S. and Hayden, M.R.
DOI: 10.3233/JHD-120038
2012

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin
Journal of Neuroscience
Waldron-Roby, E. and Ratovitski, T. and Wang, X. and Jiang, M. and Watkin, E. and Arbez, N. and Graham, R.K. and Hayden, M.R. and Hou, Z. and Mori, S. and Swing, D. and Pletnikov, M. and Duan, W. and Tessarollo, L. and Ross, C.A.
DOI: 10.1523/JNEUROSCI.1305-11.2012
2012

Polyglutamine diseases and the risk of cancer
The Lancet Oncology
Pouladi, M.A. and Hayden, M.R.
DOI: 10.1016/S1470-2045(12)70167-5
2012

Pharmacogenetics of Warfarin in Children
Pharmacoepidemiology and Drug Safety
Shaw, K. and Amstutz, U. and Hildebrand, C. and Rassekh, S. R. and Ross, C. J. and Hayden, M. R. and Carleton, B. C.
2012

miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets
Diabetes
Wijesekara, N. and Zhang, L.-H. and Kang, M.H. and Abraham, T. and Bhattacharjee, A. and Warnock, G.L. and Verchere, C.B. and Hayden, M.R.
DOI: 10.2337/db11-0944
2012

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice
Human Molecular Genetics
Pouladi, M.A. and Stanek, L.M. and Xie, Y. and Franciosi, S. and Southwell, A.L. and Deng, Y. and Butland, S. and Zhang, W. and Cheng, S.H. and Shihabuddin, L.S. and Hayden, M.R.
DOI: 10.1093/hmg/dds037
2012

Human Mendelian pain disorders: A key to discovery and validation of novel analgesics
Clinical Genetics
Goldberg, Y. and Pimstone, S. and Namdari, R. and Price, N. and Cohen, C. and Sherrington, R. and Hayden, M.
DOI: 10.1111/j.1399-0004.2012.01942.x
2012

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin
Pharmacogenomics Journal
Brunham, L.R. and Lansberg, P.J. and Zhang, L. and Miao, F. and Carter, C. and Hovingh, G.K. and Visscher, H. and Jukema, J.W. and Stalenhoef, A.F. and Ross, C.J.D. and Carleton, B.C. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1038/tpj.2010.92
2012

Treatment of Na v1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
Pain
Goldberg, Y.P. and Price, N. and Namdari, R. and Cohen, C.J. and Lamers, M.H. and Winters, C. and Price, J. and Young, C.E. and Verschoof, H. and Sherrington, R. and Pimstone, S.N. and Hayden, M.R.
DOI: 10.1016/j.pain.2011.09.008
2012

Personalized Medicine: Temper Expectations Response
Science
Brunham, L. R. and Hayden, M. R.
2012

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
Neurobiology of Disease
Pouladi, M.A. and Brillaud, E. and Xie, Y. and Conforti, P. and Graham, R.K. and Ehrnhoefer, D.E. and Franciosi, S. and Zhang, W. and Poucheret, P. and Compte, E. and Maurel, J.-C. and Zuccato, C. and Cattaneo, E. and Néri, C. and Hayden, M.R.
DOI: 10.1016/j.nbd.2012.06.026
2012

Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired ß-cell function
Diabetes
Kruit, J.K. and Wijesekara, N. and Westwell-Roper, C. and Vanmierlo, T. and De Haan, W. and Bhattacharjee, A. and Tang, R. and Wellington, C.L. and LütJohann, D. and Johnson, J.D. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.
DOI: 10.2337/db11-1341
2012

Economic impact of a genetic test for cisplatin-induced ototoxicity
Pharmacogenomics Journal
Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.
DOI: 10.1038/tpj.2011.15
2012

Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region
American Journal of Human Genetics
Lee, J.-M. and Gillis, T. and Mysore, J.S. and Ramos, E.M. and Myers, R.H. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Squitieri, F. and Griguoli, A. and Di Donato, S. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Sequeiros, J. and MacDonald, M.E. and Gusella, J.F.
DOI: 10.1016/j.ajhg.2012.01.005
2012

Age-dependent resistance to excitotoxicity in Htt CAG140 mice and the effect of strain background
Journal of Huntington's Disease
Strong, M.K. and Southwell, A.L. and Yonan, J.M. and Hayden, M.R. and Macgregor, G.R. and Thompson, L.M. and Steward, O.
DOI: 10.3233/JHD-129005
2012

Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Tietjen, I. and Hovingh, G.K. and Singaraja, R. and Radomski, C. and McEwen, J. and Chan, E. and Mattice, M. and Legendre, A. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1016/j.bbalip.2011.08.006
2012

Development of the Huntington disease work function scale
Journal of Occupational and Environmental Medicine
Brossman, B. and Williams, J.K. and Downing, N. and Mills, J.A. and Paulsen, J.S. and Wassink, T. and Cross, S. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E.A. and Beglinger, L.J. and Chiu, E. and Yastrubetskaya, O. and Preston, J. and Goh, A. and Fonseka, C. and Antonopoulos, S. and Loi, S. and Chua, P. and Komiti, A. and Raymond, L. and Dar Santos, R. and Carter, K. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Shpritz, B. and Yoritomo, N. and Welsh, C. and Mallonee, W.M. and Suter, G. and Addison, J. and Samii, A. and Macaraeg, A. and Jones, R. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and Goodman, A. and Dipietro, A. and McCusker, E. and Griffith, J. and Loy, C. and Gunn, D. and Landwehrmeyer, B.G. and Orth, M. and Sü?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Karmalkar, I. and Perlman, S. and Clemente, B. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Kang, G. and Warner, T. and Burrows, M. and Novak, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Price, K. and Hunt, S. and Marshall, F. and Chesire, A. and Wodarski, M. and Hickey, C. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Panegyres, P. and Lee, J. and Andrew, S. and Perlmutter, J. and Barton, S. and Schmidt, A. and Miedzybrodzka, Z. and Rae, D. and D?alessandro, M. and Craufurd, D. and Fullam, R. and Bek, J. and Howard, E. and Mazzoni, P. and Marder, K. and Wasserman, P. and Kumar, R. and Erickson, D. and Wheelock, V. and Tempkin, T. and Kjer, L. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and Martin, W. and King, P. and Wieler, M. and Sran, S. and Ahmed, A. and Rao, S. and Reece, C. and Zimbelman, J. and Bea, A. and Newman, E. and Bura, A. and Mourany, L. and Schulz, J. and Paulsen, J. and Johnson, H. and Smith, M. and Williams, J. and Long, J.D. and Aylward, E. and Biglan, K. and Leavitt, B. and Macdonald, M. and Nance, M. and Erwin, C. and Hayden, M. and Didonato, S. and Evans, K. and Matson, W. and Peterson, A. and Borowsky, B. and Juhl, A. and Wang, K. and Weir, D. and Vonsattell, J.P. and Moskowitz, C. and Leserman, A. and Schaul, L. and Vik, S. and Harrington, D. and Castillo, G. and Morison, J. and Reed, J. and Diaz, M. and Dobbins, I. and Hershey, T. and Foster, E. and Moore, D. and Westervelt, H. and Davis, J. and Tremont, G. and Moser, D.J. and Rowe, K. and Wenman, G. and Theriault, D. and Gehl, C. and Matheson, K. and Siedlecki, K. and Van Walsem, M. and Bonner, S. and Elias, G. and Gover, M. and Bernier, R. and Faust, M. and Borowski, B. and Carlozzi, N. and Duff, K. and Georgiou-Karistianis, N. and Stout, J. and Lange, H. and Papp, K. and Ro, E. and Clark, L.A. and Laing, J. and Rees, K. and Harreld, M. and Ready, R. and Vaccarino, A. and Farias, S. and Gusella, J. and Myers, R. and Juhl, A. and Pierson, R. and Jones, K. and Marietta, J. and McDowell, W. and Harris, G. and Kim, E.Y. and Ashburner, J. and Potkin, S. and Toga, A. and Axelson, E. and Miller, M. and Reading, S. and Beg, M.F. and Magnotta, V.A. and Helmer, K. and Lim, K. and Lowe, M. and Mori, S. and Song, A. and Turner, J. and Rao, S. and Beall, E. and Koenig, K. and Phillips, M. and Bryant, A. and Corey-Bloom, J. and Geschwind, M. and Reilmann, R. and Unds, Z. and Fiedorowicz, J. and Robinson, R. and Ruggle, A. and Liu, D. and Moser, D. and Anderson, K. and Groves, M. and Rickards, H. and van Duijn, E. and Kim, J.-I. and Harrison, B. and Zhang, Y. and Lu, W. and Lourens, S. and Doucette, N. and Thumma, K. and Waterman, E. and Hinkel, J. and Hughes, L. and Connell, R.J. and Pease, K. and Rogers, B. and Smith, J. and Wu, S. and Zschiegner, R. and Carney, E. and McKirgan, B. and Scully, M. and Wyse, R. and Bockholt, J. and Werling-Witkoske, C. and Ennis, G. and Anderson, K. and Rapp, J. and Thompson, S. and Davis, L. and Henneberry, M. and Dudler, A. and Schumacher, J. and Stout, C. and Blanchard, S. and Montross, K. and Danzer, P.
DOI: 10.1097/JOM.0b013e31825f30ab
2012

Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia
Journal of Pediatrics
Lam, J. and Kelly, L. and Ciszkowski, C. and Landsmeer, M.L.A. and Nauta, M. and Carleton, B.C. and Hayden, M.R. and Madadi, P. and Koren, G.
DOI: 10.1016/j.jpeds.2011.06.050
2012

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
Neurology
Lee, J.-M. and Ramos, E.M. and Lee, J.-H. and Gillis, T. and Mysore, J.S. and Hayden, M.R. and Warby, S.C. and Morrison, P. and Nance, M. and Ross, C.A. and Margolis, R.L. and Squitieri, F. and Orobello, S. and Di Donato, S. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J.A. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Sequeiros, J. and Paulsen, J.S. and Landwehrmeyer, G.B. and Myers, R.H. and MacDonald, M.E. and Gusella, J.F.
DOI: 10.1212/WNL.0b013e318249f683
2012

Apnea and oxygen desaturations in children treated with opioids after adenotonsillectomy for obstructive sleep apnea syndrome: A prospective pilot study
Pediatric Drugs
Khetani, J.D. and Madadi, P. and Sommer, D.D. and Reddy, D. and Sistonen, J. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.
DOI: 10.2165/11633570
2012

Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases
Progress in Neurobiology
Young, F.B. and Butland, S.L. and Sanders, S.S. and Sutton, L.M. and Hayden, M.R.
DOI: 10.1016/j.pneurobio.2011.11.002
2012

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: The devil is in the details
Therapeutic Drug Monitoring
Lam, J. and Matlow, J.N. and Ross, C.J.D. and Hayden, M.R. and Carleton, B.C. and Madadi, P.
DOI: 10.1097/FTD.0b013e31825da19f
2012

Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children
Journal of Clinical Oncology
Visscher, H. and Ross, C.J.D. and Rassekh, S.R. and Barhdadi, A. and Dubé, M.-P. and Al-Saloos, H. and Sandor, G.S. and Caron, H.N. and Van Dalen, E.C. and Kremer, L.C. and Van Der Pal, H.J. and Brown, A.M.K. and Rogers, P.C. and Phillips, M.S. and Rieder, M.J. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1200/JCO.2010.34.3467
2012

Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice
PLoS ONE
Young, F.B. and Franciosi, S. and Spreeuw, A. and Deng, Y. and Sanders, S. and Tam, N.C.M. and Huang, K. and Singaraja, R.R. and Zhang, W. and Bissada, N. and Kay, C. and Hayden, M.R.
DOI: 10.1371/journal.pone.0036315
2012

Apnea and Oxygen Desaturations in Children Treated with Opioids after Adenotonsillectomy for Obstructive Sleep Apnea Syndrome A Prospective Pilot Study
Pediatric Drugs
Khetani, J. D. and Madadi, P. and Sommer, D. D. and Reddy, D. and Sistonen, J. and Ross, C. J. D. and Carleton, B. C. and Hayden, M. R. and Koren, G.
2012

Adoption and the communication of genetic risk: Experiences in Huntington disease
Clinical Genetics
Bombard, Y. and Semaka, A. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.2010.01614.x
2012

TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease
Biochemical and Biophysical Research Communications
Lee, J.-H. and Lee, J.-M. and Ramos, E.M. and Gillis, T. and Mysore, J.S. and Kishikawa, S. and Hadzi, T. and Hendricks, A.E. and Hayden, M.R. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Squitieri, F. and Gellera, C. and Gomez-Tortosa, E. and Ayuso, C. and Suchowersky, O. and Trent, R.J. and McCusker, E. and Novelletto, A. and Frontali, M. and Jones, R. and Ashizawa, T. and Frank, S. and Saint-Hilaire, M.-H. and Hersch, S.M. and Rosas, H.D. and Lucente, D. and Harrison, M.B. and Zanko, A. and Abramson, R.K. and Marder, K. and Sequeiros, J. and Bernhard Landwehrmeyer, G. and Shoulson, I. and Myers, R.H. and MacDonald, M.E. and Gusella, J.F.
DOI: 10.1016/j.bbrc.2012.06.120
2012

PHARMACOGENETIC INSIGHT INTO OXYCODONE: IMPLICATIONS TO BREASTFEEDING MOTHERS AND NEONATES DURING THE POSTPARTUM PERIOD
Clinical Pharmacology & Therapeutics
Lam, J. and Madadi, P. and Matok, I. and Kelly, L. and Carleton, B. C. and Hayden, M. R. and Koren, G.
2012

Beyond the patient: The broader impact of genetic discrimination among individuals at risk of huntington disease
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Bombard, Y. and Palin, J. and Friedman, J.M. and Veenstra, G. and Creighton, S. and Bottorff, J.L. and Hayden, M.R. and Guttman, M. and Giambattista, C. and Ludman, M. and Murphy, J. and Babineau-Sturk, T. and MacLeod, P. and Rice, J. and Martin, W. and Wieler, M. and Meschino, W. and Gibbons, C. and Raymond, L. and Decolongon, J. and Suchowersky, O. and Klimek, M.-L.
DOI: 10.1002/ajmg.b.32016
2012

Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases
Trends in Molecular Medicine
Southwell, A.L. and Skotte, N.H. and Bennett, C.F. and Hayden, M.R.
DOI: 10.1016/j.molmed.2012.09.001
2012

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol
PLoS ONE
Tietjen, I. and Hovingh, G.K. and Singaraja, R.R. and Radomski, C. and Barhdadi, A. and McEwen, J. and Chan, E. and Mattice, M. and Legendre, A. and Franchini, P.L. and Dubé, M.-P. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1371/journal.pone.0037437
2012

Cognitive domains that predict time to diagnosis in prodromal Huntington disease
Journal of Neurology, Neurosurgery and Psychiatry
Harrington, D.L. and Smith, M.M. and Zhang, Y. and Carlozzi, N.E. and Paulsen, J.S. and Wassink, T. and Cross, S. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E.A. and Beglinger, L.J. and Chiu, E. and Yastrubetskaya, O. and Preston, J. and Goh, A. and Fonseka, C. and Antonopoulos, S. and Loi, S. and Chua, P. and Komiti, A. and Raymond, L. and Dar Santos, R. and Carter, K. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Shpritz, B. and Yoritomo, N. and Welsh, C. and Mallonee, W.M. and Suter, G. and Addison, J. and Samii, A. and Macaraeg, A. and Jones, R. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and Goodman, A. and Dipietro, A. and McCusker, E. and Griffith, J. and Loy, C. and Gunn, D. and Landwehrmeyer, B.G. and Orth, M. and Sü?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Karmalkar, I. and Perlman, S. and Clemente, B. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Kang, G. and Warner, T. and Burrows, M. and Novak, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Price, K. and Hunt, S. and Marshall, F. and Chesire, A. and Wodarski, M. and Hickey, C. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Panegyres, P. and Lee, J. and Andrew, S. and Perlmutter, J. and Barton, S. and Schmidt, A. and Miedzybrodzka, Z. and Rae, D. and D?alessandro, M. and Craufurd, D. and Fullam, R. and Bek, J. and Howard, E. and Mazzoni, P. and Marder, K. and Wasserman, P. and Kumar, R. and Erickson, D. and Wheelock, V. and Tempkin, T. and Kjer, L. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and Martin, W. and King, P. and Wieler, M. and Sran, S. and Ahmed, A. and Rao, S. and Reece, C. and Zimbelman, J. and Bea, A. and Newman, E. and Bura, A. and Mourany, L. and Schulz, J. and Johnson, H. and Williams, J. and Beglinger, L. and Long, J.D. and Mills, J.A. and Aylward, E. and Biglan, K. and Leavitt, B. and Macdonald, M. and Nance, M. and Erwin, C. and Hayden, M. and Didonato, S. and Evans, K. and Matson, W. and Peterson, A. and Borowsky, B. and Juhl, A. and Wang, K. and Weir, D. and Vonsattell, J.P. and Moskowitz, C. and Leserman, A. and Schaul, L. and Vik, S. and Castillo, G. and Morison, J. and Reed, J. and Diaz, M. and Dobbins, I. and Hershey, T. and Foster, E. and Moore, D. and Westervelt, H. and Davis, J. and Tremont, G. and Moser, D.J. and Rowe, K. and Wenman, G. and Theriault, D. and Gehl, C. and Matheson, K. and Siedlecki, K. and Van Walsem, M. and Bonner, S. and Elias, G. and Gover, M. and Bernier, R. and Faust, M. and Borowski, B. and Duff, K. and Georgiou-Karistianis, N. and Stout, J. and Lange, H. and Papp, K. and Ro, E. and Clark, L.A. and Downing, N. and Laing, J. and Rees, K. and Harreld, M. and Ready, R. and Vaccarino, A. and Farias, S. and Gusella, J. and Myers, R. and Mills, J. and Pierson, R. and Jones, K. and Marietta, J. and McDowell, W. and Harris, G. and Kim, E.Y. and Ashburner, J. and Potkin, S. and Toga, A. and Axelson, E. and Miller, M. and Reading, S. and Beg, M.F. and Magnotta, V.A. and Helmer, K. and Lim, K. and Lowe, M. and Mori, S. and Song, A. and Turner, J. and Beall, E. and Koenig, K. and Phillips, M. and Bryant, A. and Corey-Bloom, J. and Reilmann, R. and Unds, Z. and Fiedorowicz, J. and Robinson, R. and Ruggle, A. and Liu, D. and Anderson, K. and Groves, M. and Rickards, H. and van Duijn, E. and Kim, J.-I. and Harrison, B. and Lu, W. and Lourens, S. and Doucette, N. and Thumma, K. and Waterman, E. and Hinkel, J. and Hughes, L. and Connell, R.J. and Pease, K. and Rogers, B. and Smith, J. and Wu, S. and Zschiegner, R. and Carney, E. and McKirgan, B. and Scully, M. and Wyse, R. and Bockholt, J. and Werling-Witkoske, C. and Ennis, G. and Bjork, K. and Thompson, S. and Davis, L. and Henneberry, M. and Dudler, A. and Schumacher, J. and Stout, C. and Blanchard, S. and Montross, K. and Danzer, P.
DOI: 10.1136/jnnp-2011-301732
2012

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease
Neurobiology of Disease
Franciosi, S. and Ryu, J.K. and Shim, Y. and Hill, A. and Connolly, C. and Hayden, M.R. and McLarnon, J.G. and Leavitt, B.R.
DOI: 10.1016/j.nbd.2011.09.003
2012

Whole-genome sequencing: The new standard of care?
Science
Brunham, L.R. and Hayden, M.R.
DOI: 10.1126/science.1220967
2012

Response
Science
Brunham, L.R. and Hayden, M.R.
DOI: 10.1126/science.337.6097.911-a
2012

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
Human Molecular Genetics
Uribe, V. and Wong, B.K.Y. and Graham, R.K. and Cusack, C.L. and Skotte, N.H. and Pouladi, M.A. and Xie, Y. and Feinberg, K. and Ou, Y. and Ouyang, Y. and Deng, Y. and Franciosi, S. and Bissada, N. and Spreeuw, A. and Zhang, W. and Ehrnhoefer, D.E. and Vaid, K. and Miller, F.D. and Deshmukh, M. and Howland, D. and Hayden, M.R.
DOI: 10.1093/hmg/dds005
2012

Peripheral and cerebral metabolic features in an animal model of Huntington's disease
2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012
Lopes, C. and Duarte, A.I. and Hayden, M. and Rego, A.C.
DOI: 10.1109/ENBENG.2012.6331390
2012

More codeine fatalities after tonsillectomy in North American children
Pediatrics
Kelly, L.E. and Rieder, M. and Van Den Anker, J. and Malkin, B. and Ross, C. and Neely, M.N. and Carleton, B. and Hayden, M.R. and Madadi, P. and Koren, G.
DOI: 10.1542/peds.2011-2538
2012

Erratum: Economic impact of a genetic test for cisplatin-induced ototoxicity (The Pharmacogenomics Journal (2012) 12 (205-213) DOI: 10.1038/tpj.2011.15)
Pharmacogenomics Journal
Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.
DOI: 10.1038/tpj.2011.21
2012

Cutaneous adverse drug reactions in children: An analysis of reports from the Canadian Pharmacogenomics Network for drug safety (CPNDS)
Journal of Population Therapeutics and Clinical Pharmacology
Castro-Pastrana, L.I. and Ghannadan, R. and Rieder, M.J. and Dahlke, E. and Hayden, M. and Carleton, B.
2011

Caspase-6 and neurodegeneration
Trends in Neurosciences
Graham, R.K. and Ehrnhoefer, D.E. and Hayden, M.R.
DOI: 10.1016/j.tins.2011.09.001
2011

A grand challenge: Providing benefits of clinical genetics to those in need
Genetics in Medicine
Hawkins, A.K. and Hayden, M.R.
DOI: 10.1097/GIM.0b013e31820c056e
2011

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14
Human Molecular Genetics
Huang, K. and Sanders, S.S. and Kang, R. and Carroll, J.B. and Sutton, L. and Wan, J. and Singaraja, R. and Young, F.B. and Liu, L. and El-Husseini, A. and Davis, N.G. and Hayden, M.R.
DOI: 10.1093/hmg/ddr242
2011

The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice
American Journal of Pathology
Ye, D. and Zhao, Y. and Hildebrand, R.B. and Singaraja, R.R. and Hayden, M.R. and Van Berkel, T.J.C. and Van Eck, M.
DOI: 10.1016/j.ajpath.2010.11.007
2011

Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics
Journal of Cardiovascular Pharmacology
Visscher, H. and Amstutz, U. and Sistonen, J. and Ross, C.J. and Hayden, M.R. and Carleton, B.C.
DOI: 10.1097/FJC.0b013e3182163b82
2011

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease
Molecular Neurodegeneration
Carroll, J.B. and Southwell, A.L. and Graham, R.K. and Lerch, J.P. and Ehrnhoefer, D.E. and Cao, L.-P. and Zhang, W.-N. and Deng, Y. and Bissada, N. and Henkelman, R. and Hayden, M.R.
DOI: 10.1186/1750-1326-6-59
2011

Diagnostic testing for vaccinomics: Is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe
OMICS A Journal of Integrative Biology
Joly, Y. and Koutrikas, G. and Ramos-Paque, E. and Zawati, M. and Gardy, J. and Hayden, M.R. and Carleton, B.C.
DOI: 10.1089/omi.2010.0135
2011

Altered palmitoylation and neuropathological deficits in mice lacking HIP14
Human Molecular Genetics
Singaraja, R.R. and Huang, K. and Sanders, S.S. and Milnerwood, A.J. and Hines, R. and Lerch, J.P. and Franciosi, S. and Drisdel, R.C. and Vaid, K. and Young, F.B. and Doty, C. and Wan, J. and Bissada, N. and Henkelman, R.M. and Green, W.N. and Davis, N.G. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1093/hmg/ddr308
2011

Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease
Neurobiology of Disease
Carroll, J.B. and Lerch, J.P. and Franciosi, S. and Spreeuw, A. and Bissada, N. and Henkelman, R.M. and Hayden, M.R.
DOI: 10.1016/j.nbd.2011.03.018
2011

The communication of pharmacogenetic research results: Participants weigh in on their informational needs in a pilot study
Journal of Population Therapeutics and Clinical Pharmacology
Madadi, P. and Joly, Y. and Avard, D. and Chitayat, D.C. and Smith, M.A. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.
2011

Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the huntington disease gene / allele-specific silencing of mutant huntingtin
Molecular Therapy
Carroll, J.B. and Warby, S.C. and Southwell, A.L. and Doty, C.N. and Greenlee, S. and Skotte, N. and Hung, G. and Bennett, C.F. and Freier, S.M. and Hayden, M.R.
DOI: 10.1038/mt.2011.201
2011

Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans
Clinical Genetics
Brunham, L.R. and Tietjen, I. and Bochem, A.E. and Singaraja, R.R. and Franchini, P.L. and Radomski, C. and Mattice, M. and Legendre, A. and Hovingh, G.K. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.2011.01682.x
2011

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Nature Medicine
Song, W. and Chen, J. and Petrilli, A. and Liot, G. and Klinglmayr, E. and Zhou, Y. and Poquiz, P. and Tjong, J. and Pouladi, M.A. and Hayden, M.R. and Masliah, E. and Ellisman, M. and Rouiller, I. and Schwarzenbacher, R. and Bossy, B. and Perkins, G. and Bossy-Wetzel, E.
DOI: 10.1038/nm.2313
2011

Cholesterol metabolism in Huntington disease
Nature Reviews Neurology
Karasinska, J.M. and Hayden, M.R.
DOI: 10.1038/nrneurol.2011.132
2011

Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL
PLoS ONE
Ding, Y. and Zhang, L. and Wang, Y. and Huang, W. and Tang, Y. and Bai, L. and Ross, C.J.D. and Hayden, M.R. and Liu, G.
DOI: 10.1371/journal.pone.0025620
2011

A quantitative method for the specific assessment of caspase-6 activity in cell culture
PLoS ONE
Ehrnhoefer, D.E. and Skotte, N.H. and Savill, J. and Nguyen, Y.T.N. and Ladha, S. and Cao, L.-P. and Dullaghan, E. and Hayden, M.R.
DOI: 10.1371/journal.pone.0027680
2011

Pharmacogenomics of serious adverse drug reactions in pediatric oncology
Journal of Population Therapeutics and Clinical Pharmacology
Ross, C.J.D. and Visscher, H. and Rod Rassekh, S. and Castro-Pastrana, L.I. and Shereck, E. and Carleton, B. and Hayden, M.R.
2011

HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia
European Journal of Human Genetics
Warby, S.C. and Visscher, H. and Collins, J.A. and Doty, C.N. and Carter, C. and Butland, S.L. and Hayden, A.R. and Kanazawa, I. and Ross, C.J. and Hayden, M.R.
DOI: 10.1038/ejhg.2010.229
2011

CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: A pilot study
Therapeutic Drug Monitoring
VanderVaart, S. and Berger, H. and Sistonen, J. and Madadi, P. and Matok, I. and Gijsen, V.M.G.J. and De Wildt, S.N. and Taddio, A. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.
DOI: 10.1097/FTD.0b013e3182272b10
2011

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease
Neurobiology of Disease
Simpson, J.M. and Gil-Mohapel, J. and Pouladi, M.A. and Ghilan, M. and Xie, Y. and Hayden, M.R. and Christie, B.R.
DOI: 10.1016/j.nbd.2010.09.012
2011

Regulatory approval for new pharmacogenomic tests: A comparative overview
Food and Drug Law Journal
Joly, Y. and Koutrikas, G. and Tassé, A.-M. and Issa, A. and Carleton, B. and Hayden, M. and Rieder, M.J. and Ramos-Paque, E. and Avard, D.
2011

Lessons from predictive testing for Huntington disease: 25 years on
Journal of Medical Genetics
Hawkins, A.K. and Ho, A. and Hayden, M.R.
DOI: 10.1136/jmedgenet-2011-100352
2011

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: Shared targets for drug development
Nature Reviews Drug Discovery
Ehrnhoefer, D.E. and Wong, B.K.Y. and Hayden, M.R.
DOI: 10.1038/nrd3556
2011

An interaction of genes in our social environment: Genetic discrimination among persons at risk for huntington disease
Challenging Genetic Determinism: New Perspectives on the Gene in Its Multiple Environments
2011

Small changes, big impact: Posttranslational modifications and function of huntingtin in huntington disease
Neuroscientist
Ehrnhoefer, D.E. and Sutton, L. and Hayden, M.R.
DOI: 10.1177/1073858410390378
2011

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules
Diabetes
Kruit, J.K. and Wijesekara, N. and Manning Fox, J.E. and Dai, X.-Q. and Brunham, L.R. and Searle, G.J. and Morgan, G.P. and Costin, A.J. and Tang, R. and Bhattacharjee, A. and Johnson, J.D. and Light, P.E. and Marsh, B.J. and MacDonald, P.E. and Verchere, C.B. and Hayden, M.R.
DOI: 10.2337/db11-0081
2011

Factors associated with experiences of genetic discrimination among individuals at risk for huntington disease
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Bombard, Y. and Palin, J.A. and Friedman, J.M. and Veenstra, G. and Creighton, S. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R. and Guttman, M. and Giambattista, C. and Ludman, M. and Murphy, J. and Babineau-Sturk, T. and MacLeod, P. and Rice, J. and Martin, W. and Wieler, M. and Meschino, W. and Gibbons, C. and Raymond, L. and Decolongon, J. and Suchowersky, O. and Klimek, M.-L.
DOI: 10.1002/ajmg.b.31130
2011

Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: A pilot study of perceptions and benefits
Clinical Pharmacology and Therapeutics
Madadi, P. and Joly, Y. and Avard, D. and Chitayat, D.C. and Smith, M.A. and Ross, C.J.D. and Carleton, B.C. and Hayden, M.R. and Koren, G.
DOI: 10.1038/clpt.2010.125
2010

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis
Human Molecular Genetics
Becanovic, K. and Pouladi, M.A. and Lim, R.S. and Kuhn, A. and Pavlidis, P. and Luthi-Carter, R. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1093/hmg/ddq018
2010

Dynamics of Macrophage Infiltration into the Arterial Wall at Different Stages of Atherosclerotic Lesion Development and Dependency on Macrophage ABCA1 Expression
Circulation
Ye, D. and Hildebrand, R. B. and Singaraja, R. R. and Hayden, M. R. and van Berkel, T. J. and Van Eck, M.
2010

Cocaine adulterant linked to neutropenia
CMAJ
Wiens, M.O. and Son, W.K. and Ross, C. and Hayden, M. and Carleton, B.
DOI: 10.1503/cmaj.090286
2010

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice
Diabetologia
Kruit, J.K. and Kremer, P.H.C. and Dai, L. and Tang, R. and Ruddle, P. and De Haan, W. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.
DOI: 10.1007/s00125-010-1691-2
2010

Challenges assessing clinical endpoints in early Huntington disease
Movement Disorders
Paulsen, J.S. and Wang, C. and Duff, K. and Barker, R. and Nance, M. and Beglinger, L. and Moser, D. and Williams, J.K. and Simpson, S. and Langbehn, D. and van Kammen, D.P. and Paulson, H. and Bastic, K. and Conybeare, R. and Humphreys, C. and Elbert, M. and Nopoulos, P. and Rodnitzky, R. and Uc, E. and Beglinger, L. and Duff, K. and Magnotta, V.A. and Cross, S. and Doucette, N. and French, S. and Hale, N. and Juhl, A. and Kuburas, H. and Mikos, A. and Reese, B. and Turner, B. and Van Der Heiden, S. and Ames, D. and Chiu, E. and Chua, P. and Yastrubetskaya, O. and Dingjan, P. and Draper, K. and Georgiou-Karistianis, N. and Goh, A. and Komiti, A. and Lemmon, C. and Raymond, L. and Decolongon, J. and Rosenblatt, A. and Ross, C. and Agarwal, A. and Gourley, L. and Shpritz, B. and Wajda, K. and Welsh, C. and Bakker, A. and Miller, R. and Mallonee, W.M. and Suter, G. and Palmer, D. and Addison, J. and Samii, A. and Lipe, H. and Bird, T. and Logsdon, R. and Weaver, K. and Field, K. and Jones, R. and Harrison, J. and Ingram, C. and Wood-Siverio, C. and Factor, S.A. and Timothy Greenamyre, J. and Testa, C. and Barker, R.A. and Mason, S. and Smith, E. and Wright, B. and McCusker, E. and Griffith, J. and Bibb, B. and Hayes, C. and Richardson, K. and Graham, S. and Landwehrmeyer, B.G. and Barth, K. and Niess, A. and Trautmann, S. and Ecker, D. and Held, C. and Weydt, P. and Orth, M. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Elliott, S. and Fonariov, Z. and Giambattista, C. and Russell, S. and Sebastian, J. and Sethna, R. and Ip, R. and Shaddick, D. and Sheinberg, A. and Stober, J. and Perlman, S. and Carroll, R. and Johnson, A. and Jackson, G. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Rose, K. and Wyss-Coray, C. and Kramer, J. and Sha, S. and Wetzel, M. and Warner, T. and Kloppel, S. and Burrows, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Golding, C. and Rosser, A. and Naji, J. and Price, K. and Handley, O.J. and Como, P. and Chesire, A. and Hickey, C. and Zimmerman, C. and Couniham, T. and Marshall, F. and Burton, C. and Wodarski, M. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Kirstein, D. and Rosas, D. and Bennett, M. and Frishman, J. and Kaneko, Y. and Landau, T. and Lausier, M. and Muir, L. and Murphy, L. and Young, A. and Skeuse, C. and Balkema, N. and Hoogenboom, W. and Leveroni, C. and Sherman, J. and Zaleta, A. and Panegyres, P. and Connor, C. and Vuletich, E. and Woodman, M. and Zombor, R. and Perlmutter, J. and Barton, S. and Kavanaugh, M. and Simpson, S.A. and Keenan, G. and Ure, A. and Summers, F. and Craufurd, D. and Fullam, R. and Macleod, R. and Sollom, A. and Howard, E. and Mazzoni, P. and Marder, K. and Williamson, J. and Moskowitz, C. and Wasserman, P. and Seeberger, L. and Diamond, A. and Erickson, D. and Judd, D. and Kasunic, T.L. and Mellick, L. and Miracle, D. and Greenwald, C. and Malleck, K. and Montellano, S. and Kumar, R. and Schneiders, J. and Wheelock, V. and Tempkin, T. and Marsano, J. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and Martin, C. and de Yebenes, J.G. and Garde, M.B. and Fatas, M. and Schwartz, C. and Sendon, J.L. and Trigo, P.M. and Nance, M. and Radtke, D. and Norberg, D. and Tupper, D. and Martin, W. and King, P. and Wieler, M. and Foster, S. and Sran, S. and Dubinsky, R. and Gray, C. and Switzer, P. and Paulsen, J. and Johnson, H. and Aylward, E. and Biglan, K. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Guttman, M. and Hayden, M. and Landwehrmeyer, B.G. and Nance, M. and Ross, C. and Stout, J.C. and Stout, J.C. and Blanchard, S. and Anderson, C. and Dudler, A. and Henneberry, M. and Montross, K. and O'brien, P. and Penziner, E. and Leserman, A. and Ludwig, B. and McAreavy, B. and Mills, J.A. and Murray, G. and Nehl, C. and Vik, S. and Wang, C. and Werling-Witkoske, C. and Bourgeois, K. and Covert, C. and Daigneault, S. and Julian-Baros, E. and Meyers, K. and Rothenburgh, K. and Olsen, B. and Orme, C. and Ross, T. and Simone, M. and Weber, J. and Zhao, H. and Queller, S. and Johnson, S.A. and Colin Campbell, J. and Peters, E. and Carlozzi, N.E. and Green, T. and Swain, S.N. and Caughlin, D. and Ward-Bluhm, B. and Whitlock, K. and Paulsen, J. and Penziner, E. and Vik, S. and Agarwal, A. and Barnes, A. and Suter, G. and Jones, R. and Griffith, J. and Lipe, H. and Barth, K. and Fox, M. and Guzijan, M. and Zanko, A. and Naji, J. and Zombor, R. and Kavanaugh, M. and Chesire, A. and Julian-Baros, E. and Kayson, E. and Tempkin, T. and Nance, M. and Quaid, K. and Paulsen, J. and Coryell, W. and Ross, C. and Kayson, E. and Shinaman, A. and Tempkin, T. and Nance, M. and Quaid, K. and Erwin, C.
DOI: 10.1002/mds.23337
2010

BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice
Journal of Neuroscience
Xie, Y. and Hayden, M.R. and Xu, B.
DOI: 10.1523/JNEUROSCI.1637-10.2010
2010

NP03, A LOW DOSE LITHIUM MICROEMULSION, IMPROVES MOTOR FUNCTION AND RESCUES STRIATAL PATHOLOGY WITHOUT TOXICITY IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
Journal of Neurology Neurosurgery and Psychiatry
Pouladi, M. A. and Brilluad, E. and Xie, Y. and Franciosi, S. and Zhang, W. N. and Zapala, M. and Compte, E. and Poucheret, P. and Maurel, J. C. and Neri, C. and Hayden, M. R.
DOI: 10.1136/jnnp.2010.222596.13
2010

In their own words: Reports of stigma and genetic discrimination by people at risk for huntington disease in the international RESPOND-HD study
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Williams, J.K. and Erwin, C. and Juhl, A.R. and Mengeling, M. and Bombard, Y. and Hayden, M.R. and Quaid, K. and Shoulson, I. and Taylor, S. and Paulsen, J.S. and Adams, W. and Elbert, M. and Chiu, E. and Goh, A. and Yastrubetskaya, O. and Agarwal, A. and Rosenblatt, A. and Welsh, C. and Marder, K. and Wasserman, P. and Moskowitz, C. and Decolongon, J. and Raymond, L.A. and Lipe, H. and Samii, A. and Williams, P. and Aylward, E. and Harrison, J.M. and Jones, R. and Wood-Siverio, C. and Wesson, M. and Biglan, K. and Chesire, A. and Como, P. and Giambattista, C. and Guttman, M. and Sheinberg, A. and Singer, A. and Griffith, J. and McCusker, E. and Richardson, K. and Tempkin, T. and Wheelock, V.L. and Johnson, A. and Linderholm, W. and Perlman, S. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Chua, P. and Komiti, A. and Panegyres, P. and Vuletich, E. and Woodman, M.
DOI: 10.1002/ajmg.b.31080
2010

HDL and LDL cholesterol significantly influence ß-cell function in type 2 diabetes mellitus
Current Opinion in Lipidology
Kruit, J.K. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.
DOI: 10.1097/MOL.0b013e328339387b
2010

Carriers of loss-of-function mutations in ABCA1 display pancreatic ß-cell dysfunction
Diabetes Care
Vergeer, M. and Brunham, L.R. and Koetsveld, J. and Kruit, J.K. and Verchere, C.B. and Kastelein, J.J.P. and Hayden, M.R. and Stroes, E.S.G.
DOI: 10.2337/dc09-1562
2010

Adenosine-triphosphate-binding cassette transporter-1 trafficking and function
Trends in Cardiovascular Medicine
Kang, M.H. and Singaraja, R. and Hayden, M.R.
DOI: 10.1016/j.tcm.2010.03.006
2010

The Canadian Pharmacogenomics Network for Drug Safety: a model for safety pharmacology.
Thyroid : official journal of the American Thyroid Association
Ross, C.J. and Visscher, H. and Sistonen, J. and Brunham, L.R. and Pussegoda, K. and Loo, T.T. and Rieder, M.J. and Koren, G. and Carleton, B.C. and Hayden, M.R. and CPNDS Consortium
DOI: 10.1089/thy.2010.1642
2010

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia
Journal of Lipid Research
Olivecrona, G. and Ehrenborg, E. and Semb, H. and Makoveichuk, E. and Lindberg, A. and Hayden, M.R. and Gin, P. and Davies, B.S.J. and Weinstein, M.M. and Fong, L.G. and Beigneux, A.P. and Young, S.G. and Olivecrona, T. and Hernell, O.
DOI: 10.1194/jlr.M002717
2010

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice (DOI:10.1016/j.neuron.2010.01.008)
Neuron
Milnerwood, A.J. and Gladding, C.M. and Pouladi, M.A. and Kaufman, A.M. and Hines, R.M. and Boyd, J.D. and Ko, R.W.Y. and Vasuta, O.C. and Graham, R.K. and Hayden, M.R. and Murphy, T.H. and Raymond, L.A.
DOI: 10.1016/j.neuron.2010.01.031
2010

Phosphorylation of huntingtin at Ser⁴²¹ in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A
Journal of Neuroscience
Metzler, M. and Gan, L. and Mazarei, G. and Graham, R.K. and Liu, L. and Bissada, N. and Lu, G. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1523/JNEUROSCI.1589-10.2010
2010

Perception, experience, and response to genetic discrimination in Huntington disease: The international RESPOND-HD study
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Erwin, C. and Williams, J.K. and Juhl, A.R. and Mengeling, M. and Mills, J.A. and Bombard, Y. and Hayden, M.R. and Quaid, K. and Shoulson, I. and Taylor, S. and Paulsen, J.S. and Adams, W. and Elbert, M. and Chiu, E. and Goh, A. and Yastrubetskaya, O. and Agarwal, A. and Rosenblatt, A. and Welsh, C. and Marder, K. and Wasserman, P. and Moskowitz, C. and Decolongon, J. and Raymond, L.A. and Lipe, H. and Samii, A. and Williams, P. and Aylward, E. and Harrison, J.M. and Jones, R. and Wood-Siverio, C. and Wesson, M. and Biglan, K. and Chesire, A. and Como, P. and Giambattista, C. and Guttman, M. and Sheinberg, A. and Singer, A. and Griffith, J. and McCusker, E. and Richardson, K. and Tempkin, T. and Wheelock, V.L. and Johnson, A. and Linderholm, W. and Perlman, S. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Chua, P. and Komiti, A. and Panegyres, P. and Vuletich, E. and Woodman, M.
DOI: 10.1002/ajmg.b.31079
2010

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice
Neuron
Milnerwood, A.J. and Gladding, C.M. and Pouladi, M.A. and Kaufman, A.M. and Hines, R.M. and Boyd, J.D. and Ko, R.W.Y. and Vasuta, O.C. and Graham, R.K. and Hayden, M.R. and Murphy, T.H. and Raymond, L.A.
DOI: 10.1016/j.neuron.2010.01.008
2010

Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice. Reply to: De Souza JC, de Oliveira CAM, Carneiro em et al. [letter]
Diabetologia
Kruit, J.K. and Brunham, L.R. and Verchere, C.B. and Hayden, M.R.
DOI: 10.1007/s00125-010-1877-7
2010

CASPASE 6 RESISTANT MUTANT HUNTINGTIN DOES NOT RESCUE THE TOXIC EFFECTS OF CASPASE CLEAVABLE MUTANT HUNTINGTIN IN VIVO
Journal of Neurology Neurosurgery and Psychiatry
Graham, R. K. and Deng, Y. and Pouladi, M. A. and Vaid, K. and Xie, Y. and Bissada, N. and Franciosi, S. and Hayden, M. R.
DOI: 10.1136/jnnp.2010.222570.4
2010

CAG-repeat length and the age of onset in Huntington Disease (HD): A review and validation study of statistical approaches
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Langbehn, D.R. and Hayden, M.R. and Paulsen, J.S. and Johnson, H. and Aylward, E. and Biglan, K. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Guttman, M. and Landwehrmeyer, B.G. and Nance, M. and Ross, C. and Stout, J.
DOI: 10.1002/ajmg.b.30992
2010

Pharmacogenomics and active surveillance for serious adverse drug reactions in children
Pharmacogenomics
Loo, T.T. and Ross, C.J.D. and Sistonen, J. and Visscher, H. and Madadi, P. and Koren, G. and Hayden, M.R. and Carleton, B.C.
DOI: 10.2217/pgs.10.111
2010

PHARMACOGENOMICS
Acta Paediatrica
Hayden, M. R.
2010

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
Human Molecular Genetics
Pouladi, M.A. and Xie, Y. and Skotte, N.H. and Ehrnhoefer, D.E. and Graham, R.K. and Kim, J.E. and Bissada, N. and Yang, X.W. and Paganetti, P. and Friedlander, R.M. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1093/hmg/ddq026
2010

Fatal hydrocodone overdose in a child: Pharmacogenetics and drug interactions
Pediatrics
Madadi, P. and Hildebrandt, D. and Gong, I.Y. and Schwarz, U.I. and Ciszkowski, C. and Ross, C.J.D. and Sistonen, J. and Carleton, B.C. and Hayden, M.R. and Lauwers, A.E. and Koren, G.
DOI: 10.1542/peds.2009-1907
2010

Effects of Endothelial Lipase Loss-of-Function Mutations on HDLc Levels in the General Population
Arteriosclerosis Thrombosis and Vascular Biology
Tietjen, Ian and Singaraja, Roshni and Hovingh, G. Kees and Motazacker, M. Madhi and Kuivenhoven, Jan Albert and Kastelein, John J. and Hayden, Michael R.
2010

CROSS SECTIONAL AND LONGITUDINAL 3T MAGNETIC RESONANCE SPECTROSCOPY IN A TRACK-HD COHORT OF INDIVIDUALS WITH PREMANIFEST AND EARLY HUNTINGTON'S DISEASE
Journal of Neurology Neurosurgery and Psychiatry
Sturrock, A. and Laule, C. and Decolongon, J. and Santos, R. D. and Coleman, A. J. and Creighton, S. and Bechtel, N. and Reilmann, R. and Hayden, M. R. and Tabrizi, S. J. and Mackay, A. L. and Leavitt, B. R.
DOI: 10.1136/jnnp.2010.222653.6
2010

Cholesterol in ß-cell dysfunction: The emerging connection between HDL cholesterol and type 2 diabetes
Current Diabetes Reports
Brunham, L.R. and Kruit, J.K. and Hayden, M.R. and Verchere, C.B.
DOI: 10.1007/s11892-009-0090-x
2010

Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes
Journal of Neuroscience
Valenza, M. and Leoni, V. and Karasinska, J.M. and Petricca, L. and Fan, J. and Carroll, J. and Pouladi, M.A. and Fossale, E. and Nguyen, H.P. and Riess, O. and MacDonald, M. and Wellington, C. and DiDonato, S. and Hayden, M. and Cattaneo, E.
DOI: 10.1523/JNEUROSCI.0917-10.2010
2010

The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone
Peptides
Glier, M.B. and Pissios, P. and Babich, S.L. and Macdonald, M.L.E. and Hayden, M.R. and Maratos-Flier, E. and Gibson, W.T.
DOI: 10.1016/j.peptides.2009.10.018
2010

Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism
Journal of Biological Chemistry
Chung, S. and Timmins, J.M. and Duong, M. and Degirolamo, C. and Rong, S. and Sawyer, J.K. and Singaraja, R.R. and Hayden, M.R. and Maeda, N. and Rudel, L.L. and Shelness, G.S. and Parks, J.S.
DOI: 10.1074/jbc.M109.096933
2010

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease
Neurobiology of Disease
Huang, K. and Kang, M.H. and Askew, C. and Kang, R. and Sanders, S.S. and Wan, J. and Davis, N.G. and Hayden, M.R.
DOI: 10.1016/j.nbd.2010.05.027
2010

Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis
Atherosclerosis
van Leuven, S.I. and van Wijk, D.F. and Volger, O.L. and de Vries, J.P.P.M. and van der Loos, C.M. and de Kleijn, D.V.P. and Horrevoets, A.J.G. and Tak, P.P. and van der Wal, A.C. and de Boer, O.J. and Pasterkamp, G. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.
DOI: 10.1016/j.atherosclerosis.2010.01.043
2010

Erratum
Trends in Cardiovascular Medicine
Kang, M.H. and Singaraja, R. and Hayden, M.R.
DOI: 10.1016/j.tcm.2010.09.001
2010

Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
Neurobiology of Disease
Soneson, C. and Fontes, M. and Zhou, Y. and Denisov, V. and Paulsen, J.S. and Kirik, D. and Petersén, ?. and Paulson, H. and Elbert, M. and Nopoulos, P. and Rodnitzky, R. and Uc, E. and Beglinger, L. and Duff, K. and Magnotta, V.A. and Cross, S. and Doucette, N. and Juhl, A. and Schumacher, J. and Kimble, M. and Ryan, P. and Wood, J. and Epping, E. and Thomsen, T. and Ames, D. and Chiu, E. and Chua, P. and Yastrubetskaya, O. and Dingjan, P. and Draper, K. and Georgiou-Karistianis, N. and Goh, A. and Komiti, A. and Raymond, L. and Dar Santos, R. and Decolongon, J. and Rosenblatt, A. and Ross, C.A. and Agarwal, A. and Shpritz, B. and Welsh, C. and Mallonee, W.M. and Suter, G. and Samii, A. and Lipe, H. and Weaver, K. and Jones, R. and Harrison, J. and Ingram, C. and Wood-Siverio, C. and Factor, S.A. and Testa, C. and Barker, R.A. and Mason, S. and McCusker, E. and Griffith, J. and Bibb, B. and Richardson, K. and Landwehrmeyer, B.G. and Ecker, D. and Weydt, P. and Orth, M. and Sü?muth, S. and Barth, K. and Trautmann, S. and Quaid, K. and Wesson, M. and Wojcieszek, J. and Guttman, M. and Sheinberg, A. and Singer, A. and Stober, J. and Perlman, S. and Johnson, A. and Geschwind, M.D. and Gooblar, J. and Guzijan, M. and Warner, T. and Kloppel, S. and Burrows, M. and Andrews, T. and Rosser, E. and Tabrizi, S. and Rosser, A. and Naji, J. and Price, K. and Handley, O.J. and Como, P. and Chesire, A. and Marshall, F. and Wodarski, M. and Suchowersky, O. and Furtado, S. and Klimek, M.L. and Rosas, D. and Young, A. and Bender, A. and Zaleta, A. and Panegyres, P. and Connor, C. and Vuletich, E. and Woodman, M. and Zombor, R. and Perlmutter, J. and Barton, S. and Simpson, S.A. and Matheson, K. and Ure, A. and Craufurd, D. and Fullam, R. and Macleod, R. and Sollom, A. and Howard, E. and Mazzoni, P. and Marder, K. and Moskowitz, C. and Wasserman, P. and Seeberger, L. and Diamond, A. and Erickson, D. and Miracle, D. and Montellano, S. and Kumar, R. and Wheelock, V. and Tempkin, T. and Marsano, J. and Sanders, M. and Baynes, K. and Jankovic, J. and Hunter, C. and Ondo, W. and de Yebenes, J.G. and Garde, M.B. and Fatas, M. and Martinez, A. and Nance, M. and Radtke, D. and Tupper, D. and Martin, W. and King, P. and Wieler, M. and Sran, S. and Langbehn, D. and Johnson, H. and Magnotta, V. and Pierson, R. and Williams, J. and Aylward, E. and Biglan, K. and Erwin, C. and Hayden, M. and Leavitt, B. and Macdonald, M. and Rao, S. and Stout, J.C. and Blanchard, S. and Dudler, A. and Henneberry, M. and Montross, K. and O'brien, P. and Mills, J.A. and Wang, C. and Werling-Witkoske, C. and Adams, W. and Anderson, K. and Thompson, S. and Didonato, S. and Mattson, W. and Petersen, A. and Harrington, D. and Westervelt, H. and Moser, D. and Smith, M. and Campbell, C. and Davison, J. and Queller, S. and Clark, L.A. and Leserman, A. and O'rourke, J. and Brossman, B. and Ro, E. and Ready, R. and Vaccarino, A. and Farias, S. and Carlozzi, N. and Nehl, C. and Gusella, J. and Myers, R. and Wassink, T. and Potkin, S. and Toga, A. and Beg, M.F. and Miller, M. and Reading, S. and Axelson, E. and Bockholt, J. and Vitense, K. and Helmer, K. and Lim, K. and Mori, S. and Song, A. and Turner, J. and Beall, E. and Koenig, K. and Lowe, M. and Phillips, M. and Reece, C. and Zimbelman, J. and Anderson, K. and Fedorowicz, J. and Robinson, R. and van Duijn, E. and Oakes, D. and Bourgeois, K. and Whitlock, K. and Vik, S. and Anderson, C. and Schumaker, J. and Reynolds, N. and Coryell, W. and Smith, J. and Connell, R.J. and Weber, J. and Werling, C. and Kayson, E. and Julian-Baros, E. and Covert, C. and Daigneault, S. and Meyers, K. and Rothenburgh, K. and Olsen, B. and Orme, C. and Ross, T. and Simone, M. and Zhao, H. and Johnson, S.A. and Colin Campbell, J. and Peters, E. and Carlozzi, N.E. and Green, T. and Swain, S.N. and Caughlin, D. and Ward-Bluhm, B. and Trautman, S. and Hersch, S.
DOI: 10.1016/j.nbd.2010.07.013
2010

A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans
Human Molecular Genetics
Acuña-Alonzo, V. and Flores-Dorantes, T. and Kruit, J.K. and Villarreal-Molina, T. and Arellano-Campos, O. and Hünemeier, T. and Moreno-Estrada, A. and Ortiz-López, M.G. and Villamil-Ramírez, H. and León-Mimila, P. and Villalobos-Comparan, M. and Jacobo-Albavera, L. and Ramírez-Jiménez, S. and Sikora, M. and Zhang, L.-H. and Pape, T.D. and de ?ngeles Granados-Silvestre, M. and Montufar-Robles, I. and Tito-Alvarez, A.M. and Zurita-Salinas, C. and Bustos-Arriaga, J. and Cedillo-Barrón, L. and Gómez-Trejo, C. and Barquera-Lozano, R. and Vieira-Filho, J.P. and Granados, J. and Romero-Hidalgo, S. and Huertas-Vázquez, A. and González-Martín, A. and Gorostiza, A. and Bonatto, S.L. and Rodríguez-Cruz, M. and Wang, L. and Tusié-Luna, T. and Aguilar-Salinas, C.A. and Lisker, R. and Moises, R.S. and Menjivar, M. and Salzano, F.M. and Knowler, W.C. and Bortolini, M.C. and Hayden, M.R. and Baier, L.J. and Canizales-Quinteros, S.
DOI: 10.1093/hmg/ddq173
2010

Unstable familial transmissions of huntington disease alleles with 27-35 CAG repeats (intermediate alleles)
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Semaka, A. and Collins, J.A. and Hayden, M.R.
DOI: 10.1002/ajmg.b.30970
2010

Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease
Neurology
Sturrock, A. and Laule, C. and Decolongon, J. and Dar Santos, R. and Coleman, A.J. and Creighton, S. and Bechtel, N. and Reilmann, R. and Hayden, M.R. and Tabrizi, S.J. and MacKay, A.L. and Leavitt, B.R.
DOI: 10.1212/WNL.0b013e3181fc27e4
2010

Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia
Experimental Biology and Medicine
Ding, Y.-L. and Wang, Y.-H. and Huang, W. and Liu, G. and Ross, C. and Hayden, M.R. and Yang, J.-K.
DOI: 10.1258/ebm.2009.009100
2010

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo
Journal of Neuroscience
Graham, R.K. and Deng, Y. and Carroll, J. and Vaid, K. and Cowan, C. and Pouladi, M.A. and Metzler, M. and Bissada, N. and Wang, L. and Faull, R.L.M. and Gray, M. and Yang, X.W. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1523/JNEUROSCI.2071-10.2010
2010

TREATMENT WITH ARIMOCLOMOL DOES NOT LEAD TO RESCUE OF MOTOR OR STRIATAL DEFICITS IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
Journal of Neurology Neurosurgery and Psychiatry
Pouladi, M. A. and Carroll, J. and Santos, R. D. and Bertram, L. and Hayden, M. R.
DOI: 10.1136/jnnp.2010.222596.12
2010

Application of principal component analysis to pharmacogenomic studies in Canada
Pharmacogenomics Journal
Visscher, H. and Ross, C.J.D. and Dubé, M.-P. and Brown, A.M.K. and Phillips, M.S. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1038/tpj.2009.36
2009

Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels
Journal of Lipid Research
Vaessen, S.F.C. and Dallinga-Thie, G.M. and Ross, C.J.D. and Splint, L.J. and Castellani, L.W. and Rensen, P.C.N. and Hayden, M.R. and Schaap, F.G. and Kuivenhoven, J.A.
DOI: 10.1194/jlr.M800551-JLR200
2009

Adverse drug reaction active surveillance: Developing a national network in Canada's children's hospitals
Pharmacoepidemiology and Drug Safety
Carleton, B.C. and Poole, R.L. and Smith, M.A. and Leeder, J.S. and Ghannadan, R. and Ross, C.J.D. and Phillips, M.S. and Hayden, M.R.
DOI: 10.1002/pds.1772
2009

Response to Falush: A Role for cis-Element Polymorphisms in HD
American Journal of Human Genetics
Warby, S.C. and Visscher, H. and Butland, S. and Pearson, C.E. and Hayden, M.R.
DOI: 10.1016/j.ajhg.2009.11.006
2009

Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: A case-control study
Clinical Pharmacology and Therapeutics
Madadi, P. and Ross, C.J.D. and Hayden, M.R. and Carleton, B.C. and Gaedigk, A. and Leeder, J.S. and Koren, G.
DOI: 10.1038/clpt.2008.157
2009

Palmitoylation of ATP-binding cassette transporter A1 Is essential for its trafficking and function
Circulation Research
Singaraja, R.R. and Kang, M.H. and Vaid, K. and Sanders, S.S. and Vilas, G.L. and Arstikaitis, P. and Coutinho, J. and Drisdel, R.C. and El Din El-Husseini, A. and Green, W.N. and Berthiaume, L. and Hayden, M.R.
DOI: 10.1161/CIRCRESAHA.108.193011
2009

Genotypic Approaches to Therapy in Children (GATC): Using information technology to improve drug safety
Studies in Health Technology and Informatics
DOI: 10.3233/978-1-58603-979-0-209
2009

Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice
Biochemical and Biophysical Research Communications
Xian, X. and Ding, Y. and Zhang, L. and Wang, Y. and McNutt, M.A. and Ross, C. and Hayden, M.R. and Deng, X. and Liu, G.
DOI: 10.1016/j.bbrc.2009.05.101
2009

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Nature Medicine
Okamoto, S.-I. and Pouladi, M.A. and Talantova, M. and Yao, D. and Xia, P. and Ehrnhoefer, D.E. and Zaidi, R. and Clemente, A. and Kaul, M. and Graham, R.K. and Zhang, D. and Vincent Chen, H.-S. and Tong, G. and Hayden, M.R. and Lipton, S.A.
DOI: 10.1038/nm.2056
2009

The role of free fatty acids, pancreatic lipase and Ca²⁺ signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice
Acta Physiologica
DOI: 10.1111/j.1748-1716.2008.01933.x
2009

Tetrabenazine
Nature Reviews Drug Discovery
Hayden, M.R. and Leavitt, B.R. and Yasothan, U. and Kirkpatrick, P.
DOI: 10.1038/nrd2784
2009

Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease
Journal of Neuroscience
Fan, J. and Cowan, C.M. and Zhang, L.Y.J. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1523/JNEUROSCI.2491-09.2009
2009

Differential susceptibility to excitotoxic stress in YAC128 mouse models of huntington disease between initiation and progression of disease
Journal of Neuroscience
Graham, R.K. and Pouladi, M.A. and Joshi, P. and Lu, G. and Deng, Y. and Wu, N.-P. and Figueroa, B.E. and Metzler, M. and André, V.M. and Slow, E.J. and Raymond, L. and Friedlander, R. and Levine, M.S. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1523/JNEUROSCI.5473-08.2009
2009

Acute hypertriglyceridemic pancreatitis during pregnancy due to homozygous lipoprotein lipase gene mutation
Clinica Chimica Acta
Bartha, I. and Dinya, T. and Seres, I. and Paragh, G. and Ross, C. and Hayden, M.R. and Biró, S. and Vargha, G.
DOI: 10.1016/j.cca.2008.10.016
2009

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
Molecular and Cellular Neuroscience
Warby, S.C. and Doty, C.N. and Graham, R.K. and Shively, J. and Singaraja, R.R. and Hayden, M.R.
DOI: 10.1016/j.mcn.2008.09.007
2009

Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
MacDonald, M.L.E. and Bissada, N. and Vallance, B.A. and Hayden, M.R.
DOI: 10.1016/j.bbalip.2009.08.001
2009

Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis
Arteriosclerosis, Thrombosis, and Vascular Biology
MacDonald, M.L.E. and Van Eck, M. and Hildebrand, R.B. and Wong, B.W.C. and Bissada, N. and Ruddle, P. and Kontush, A. and Hussein, H. and Pouladi, M.A. and Chapman, M.J. and Fievet, C. and Van Berkel, T.J.C. and Staels, B. and McManus, B.M. and Hayden, M.R.
DOI: 10.1161/ATVBAHA.108.181099
2009

Mouse models of Huntington disease: Variations on a theme
DMM Disease Models and Mechanisms
Ehrnhoefer, D.E. and Butland, S.L. and Pouladi, M.A. and Hayden, M.R.
DOI: 10.1242/dmm.002451
2009

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Journal of Cell Biology
Thompson, L.M. and Aiken, C.T. and Kaltenbach, L.S. and Agrawal, N. and Illes, K. and Khoshnan, A. and Martinez-Vincente, M. and Arrasate, M. and O'Rourke, J.G. and Khashwji, H. and Lukacsovich, T. and Zhu, Y.-Z. and Lau, A.L. and Massey, A. and Hayden, M.R. and Zeitlin, S.O. and Finkbeiner, S. and Green, K.N. and LaFerla, F.M. and Bates, G. and Huang, L. and Patterson, P.H. and Lo, D.C. and Cuervo, A.M. and Marsh, J.L. and Steffan, J.S.
DOI: 10.1083/jcb.200909067
2009

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenesinfection
Proceedings of the National Academy of Sciences of the United States of America
Yeretssian, G. and Doiron, K. and Shao, W. and Leavitt, B.R. and Hayden, M.R. and Nicholson, D.W. and Saleh, M.
DOI: 10.1073/pnas.0813362106
2009

Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function
Journal of Neuroscience
Karasinska, J.M. and Rinninger, F. and Lütjohann, D. and Ruddle, P. and Franciosi, S. and Kruit, J.K. and Singaraja, R.R. and Hirsch-Reinshagen, V. and Fan, J. and Brunham, L.R. and Bissada, N. and Ramakrishnan, R. and Wellington, C.L. and Parks, J.S. and Hayden, M.R.
DOI: 10.1523/JNEUROSCI.4741-08.2009
2009

Presynaptic defects impair learning and memory function in lipoprotein lipase deficient mice
Journal of Neurochemistry
Yu, J. and Liu, T. T. and Xian, X. D. and Wang, Y. H. and Miao, Y. F. and Zhang, J. J. and Yu, Y. and Ross, C. and Hayden, M. R. and Liu, G. and Chui, D. H.
2009

Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells
Gut
Wang, Y. and Sternfeld, L. and Yang, F. and Rodriguez, J.A. and Ross, C. and Hayden, M.R. and Carriere, F. and Liu, G. and Hofer, W. and Schulz, I.
DOI: 10.1136/gut.2007.146258
2009

CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup
American Journal of Human Genetics
Warby, S.C. and Montpetit, A. and Hayden, A.R. and Carroll, J.B. and Butland, S.L. and Visscher, H. and Collins, J.A. and Semaka, A. and Hudson, T.J. and Hayden, M.R.
DOI: 10.1016/j.ajhg.2009.02.003
2009

Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of huntington disease
Journal of Neuroscience
Joshi, P.R. and Wu, N.-P. and André, V.M. and Cummings, D.M. and Cepeda, C. and Joyce, J.A. and Carroll, J.B. and Leavitt, B.R. and Hayden, M.R. and Levine, M.S. and Bamford, N.S.
DOI: 10.1523/JNEUROSCI.5687-08.2009
2009

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis
Arteriosclerosis, Thrombosis, and Vascular Biology
Brunham, L.R. and Singaraja, R.R. and Duong, M. and Timmins, J.M. and Fievet, C. and Bissada, N. and Kang, M.H. and Samra, A. and Fruchart, J.-C. and McManus, B. and Staels, B. and Parks, J.S. and Hayden, M.R.
DOI: 10.1161/ATVBAHA.108.182303
2009

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
Brain
Pouladi, M.A. and Graham, R.K. and Karasinska, J.M. and Xie, Y. and Santos, R.D. and Petersn, Â. and Hayden, M.R.
DOI: 10.1093/brain/awp006
2009

Presynaptic defects underlying impaired learning and memory function in lipoprotein Lipase-deficient mice
Journal of Neuroscience
Xian, X. and Liu, T. and Yu, J. and Wang, Y. and Miao, Y. and Zhang, J. and Yu, Y. and Ross, C. and Karasinska, J.M. and Hayden, M.R. and Liu, G. and Chui, D.
DOI: 10.1523/JNEUROSCI.0297-09.2009
2009

Perceptions of genetic discrimination among people at risk for Huntington’s disease: A cross sectional survey
BMJ (Online)
Bombard, Y. and Veenstra, G. and Friedman, J.M. and Creighton, S. and Currie, L. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R. and Guttman, M. and Giambattista, C. and Ludman, M. and Murphy, J. and Babineau-Sturk, T. and Macleod, P. and Rice, J. and Martin, W. and Wieler, M. and Meschino, W. and Gibbons, C. and Raymond, L. and Decolongon, J. and Suchowersky, O. and Klimek, M.-L.
DOI: 10.1136/bmj.b2175
2009

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity
FASEB Journal
Huang, K. and Sanders, S. and Singaraja, R. and Orban, P. and Cijsouw, T. and Arstikaitis, P. and Yanai, A. and Hayden, M.R. and El-Husseini, A.
DOI: 10.1096/fj.08-127399
2009

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells
Journal of Biological Chemistry
Ratovitski, T. and Gucek, M. and Jiang, H. and Chighladze, E. and Waldron, E. and D'Ambola, J. and Zhipeng, H. and Yideng, L. and Poirier, M.A. and Hirschhorn, R.R. and Graham, R. and Hayden, M.R. and Cole, R.N. and Ross, C.A.
DOI: 10.1074/jbc.M804813200
2009

Motor abnormalities in premanifest persons with Huntington's disease: The PREDICT-HD study
Movement Disorders
Biglan, K.M. and Ross, C.A. and Langbehn, D.R. and Aylward, E.H. and Stout, J.C. and Queller, S. and Carlozzi, N.E. and Duff, K. and Beglinger, L.J. and Paulsen, J.S. and Johnson, H. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Guttman, M. and Hayden, M. and Landwehrmeyer, B.G. and Nance, M.
DOI: 10.1002/mds.22601
2009

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
Nature Genetics
Ross, C.J.D. and Katzov-Eckert, H. and Dubé, M.-P. and Brooks, B. and Rassekh, S.R. and Barhdadi, A. and Feroz-Zada, Y. and Visscher, H. and Brown, A.M.K. and Rieder, M.J. and Rogers, P.C. and Phillips, M.S. and Carleton, B.C. and Hayden, M.R.
DOI: 10.1038/ng.478
2009

Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease
NeuroImage
Lerch, J.P. and Carroll, J.B. and Dorr, A. and Spring, S. and Evans, A.C. and Hayden, M.R. and Sled, J.G. and Henkelman, R.M.
DOI: 10.1016/j.neuroimage.2008.02.019
2008

Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: Impact on NMDA receptor function and toxicity
Journal of Neuroscience
Cowan, C.M. and Fan, M.M.Y. and Fan, J. and Shehadeh, J. and Zhang, L.Y.J. and Graham, R.K. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1523/JNEUROSCI.4619-08.2008
2008

A toxicogenetic case-control study of codeine toxicity during breastfeeding
Clinical Pharmacology & Therapeutics
Madadi, P. and Ross, C. J. and Pape, T. and Gaedigk, A. and Carleton, B. C. and Hayden, M. R. and Leeder, S. J. and Korens, G.
2008

A humanized BAC transgenic/knockout mouse model for human caspase-12 polymorphism
Cytokine
Yeretssian, Garabet and Hayden, Michael R. and Nicholson, Donald W. and Saleh, Maya
DOI: 10.1016/j.cyto.2008.07.091
2008

Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet
Circulation Research
Zhang, X. and Qi, R. and Xian, X. and Yang, F. and Blackstein, M. and Deng, X. and Fan, J. and Ross, C. and Karasinska, J. and Hayden, M.R. and Liu, G.
DOI: 10.1161/CIRCRESAHA.107.156554
2008

Intramuscular administration of AAV1-lipoprotein lipase^S447X lowers triglycerides in lipoprotein lipase-deficient patients
Arteriosclerosis, Thrombosis, and Vascular Biology
Stroes, E.S. and Nierman, M.C. and Meulenberg, J.J. and Franssen, R. and Twisk, J. and Henny, C.P. and Maas, M.M. and Zwinderman, A.H. and Ross, C. and Aronica, E. and High, K.A. and Levi, M.M. and Hayden, M.R. and Kastelein, J.J. and Kuivenhoven, J.A.
DOI: 10.1161/ATVBAHA.108.175620
2008

Intermediate alleles for Huntington's disease: Patient understanding and current genetic counselling practices
Journal of Neurology Neurosurgery and Psychiatry
Semaka, A. and Balneaves, L. and Hayden, M. R.
2008

Cholesterol in islet dysfunction and type 2 diabetes
Journal of Clinical Investigation
Brunham, L.R. and Kruit, J.K. and Verchere, C.B. and Hayden, M.R.
DOI: 10.1172/JCI33296
2008

Automated deformation analysis in the YAC128 Huntington disease mouse model
NeuroImage
Lerch, J.P. and Carroll, J.B. and Spring, S. and Bertram, L.N. and Schwab, C. and Hayden, M.R. and Mark Henkelman, R.
DOI: 10.1016/j.neuroimage.2007.08.033
2008

Activation of caspase-6 is an early event in acute and chronic models of Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Graham, R. K. and Deng, Y. and Vaid, K. and Bissada, N. and Murphy, Z. and Wang, L. and Hayden, M. R.
2008

Caspases-2 and 6 as drug targets in Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Carroll, J. B. and Ehrnhoefer, D. E. and Graham, R. K. and Cao, L-P and Hayden, M. R.
2008

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
Human Molecular Genetics
Warby, S.C. and Doty, C.N. and Graham, R.K. and Carroll, J.B. and Yang, Y.-Z. and Singaraja, R.R. and Overall, C.M. and Hayden, M.R.
DOI: 10.1093/hmg/ddn139
2008

Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice
Journal of Lipid Research
MacDonald, M.L.E. and Singaraja, R.R. and Bissada, N. and Ruddle, P. and Watts, R. and Karasinska, J.M. and Gibson, W.T. and Fievet, C. and Vance, J.E. and Staels, B. and Hayden, M.R.
DOI: 10.1194/jlr.M700478-JLR200
2008

Engagement with genetic discrimination: Concerns and experiences in the context of Huntington disease
European Journal of Human Genetics
Bombard, Y. and Penziner, E. and Suchowersky, O. and Guttman, M. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R.
DOI: 10.1038/sj.ejhg.5201937
2008

Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic Beta Cell Dysfunction
Circulation
Vergeer, Menno and Brunham, Liam R. and Koetsveld, Joris and Kruit, Janine K. and Verchere, C. B. and Kastelein, John J. and Hayden, Michael R. and Stroes, Erik S.
2008

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
Human Molecular Genetics
Wang, C.-E. and Tydlacka, S. and Orr, A.L. and Yang, S.-H. and Graham, R.K. and Hayden, M.R. and Li, S. and Chan, A.W.S. and Li, X.-J.
DOI: 10.1093/hmg/ddn175
2008

Full length mutant huntingtin is required for altered Ca²⁺ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease
Neurobiology of Disease
Zhang, H. and Li, Q. and Graham, R.K. and Slow, E. and Hayden, M.R. and Bezprozvanny, I.
DOI: 10.1016/j.nbd.2008.03.010
2008

Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors
Journal of Neurochemistry
Fan, M.M.Y. and Zhang, H. and Hayden, M.R. and Pelech, S.L. and Raymond, L.A.
DOI: 10.1111/j.1471-4159.2007.05016.x
2008

Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Penziner, E. and Williams, J.K. and Erwin, C. and Bombard, Y. and Wallis, A. and Beglinger, L.J. and Hayden, M.R. and Paulsen, J.S.
DOI: 10.1002/ajmg.b.30600
2008

ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease
JAMA - Journal of the American Medical Association
Brunham, L.R. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1001/jama.2008.539
2008

Response to the letter by Ebara et al
Circulation Research
Liu, G. and Hayden, M.R.
DOI: 10.1161/CIRCRESAHA.108.178715
2008

Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats
Movement Disorders
Semaka, A. and Warby, S. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1002/mds.21820
2008

A toxicogenetic case-control study of codeine toxicity during breastfeeding.
Clinical Pharmacology & Therapeutics
Madadi, P. and Ross, C. J. and Pape, T. and Gaedigk, A. and Carleton, B. C. and Hayden, M. R. and Leeder, S. J. and Korens, G.
2008

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Journal of Experimental Medicine
Björkqvist, M. and Wild, E.J. and Thiele, J. and Silvestroni, A. and Andre, R. and Lahiri, N. and Raibon, E. and Lee, R.V. and Benn, C.L. and Soulet, D. and Magnusson, A. and Woodman, B. and Landles, C. and Pouladi, M.A. and Hayden, M.R. and Khalili-Shirazi, A. and Lowdell, M.W. and Brundin, P. and Bates, G.P. and Leavitt, B.R. and Möller, T. and Tabrizi, S.J.
DOI: 10.1084/jem.20080178
2008

Mechanisms of altered N-methyl-D-aspartate receptor-mediated calcium signaling in the YAC mouse model of Huntington's disease
Journal of General Physiology
Milnerwood, A. and Gladding, C. and Hayden, M. R. and Murphy, T. H. and Raymond, L. A.
2008

Detection of Huntington's disease decades before diagnosis: The Predict-HD study
Journal of Neurology, Neurosurgery and Psychiatry
Paulsen, J.S. and Langbehn, D.R. and Stout, J.C. and Aylward, E. and Ross, C.A. and Nance, M. and Guttman, M. and Johnson, S. and MacDonald, M. and Beglinger, L.J. and Duff, K. and Kayson, E. and Biglan, K. and Shoulson, I. and Oakes, D. and Hayden, M.
DOI: 10.1136/jnnp.2007.128728
2008

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation
Human Molecular Genetics
Valenza, M. and Carroll, J.B. and Leoni, V. and Bertram, L.N. and Björkhem, I. and Singaraja, R.R. and Di Donato, S. and Lutjohann, D. and Hayden, M.R. and Cattaneo, E.
DOI: 10.1093/hmg/ddm170
2007

ß-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
Nature Medicine
Brunham, L.R. and Kruit, J.K. and Pape, T.D. and Timmins, J.M. and Reuwer, A.Q. and Vasanji, Z. and Marsh, B.J. and Rodrigues, B. and Johnson, J.D. and Parks, J.S. and Verchere, C.B. and Hayden, M.R.
DOI: 10.1038/nm1546
2007

The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset
Annals of Human Genetics
Andresen, J.M. and Gayán, J. and Djoussé, L. and Roberts, S. and Brocklebank, D. and Cherny, S.S. and Cardon, L.R. and Gusella, J.F. and Macdonald, M.E. and Myers, R.H. and Housman, D.E. and Wexler, N.S. and Lorimer, J. and Porter, J. and Gomez, F. and Moskowitz, C. and Gerstenhaber, K.P. and Shackell, E. and Marder, K. and Penchaszadeh, G. and Roberts, S.A. and Brickman, A. and Brocklebank, D. and Gray, J. and Dlouhy, S.R. and Wiktorski, S. and Hodes, M.E. and Conneally, P.M. and Penney, J.B. and Gusella, J.F. and Cha, J.-H. and Irizarry, M. and Rosas, D. and Hersch, S. and Hollingsworth, Z. and Young, A.B. and Housman, D.E. and de Young, M.M. and Bonilla, E. and Stillings, T. and Negrette, A. and Snodgrass, S.R. and Martinez-Jaurrieta, M.D. and Ramos-Arroyoh, M.A. and Bickham, J. and Ramos, J.S. and Marshall, F. and Shoulson, I. and Rey, G.J. and Feigin, A. and Arnheim, N. and Acevedo-Cruz, A. and Acosta, L. and Alvir, J. and Fischbeck, K. and Thompson, L.M. and Young, A. and Dure, L. and O'Brien, C.J. and Paulsen, J. and Moran, S.P. and Krch, D. and Hogarth, P. and Higgins Jr., D.S. and Landwehrmeyer, B. and Hayden, M.R. and Almqvist, E.W. and Brinkman, R.R. and Suchowersky, O. and Durr, A. and Dodé, C.Catherine and Squitieri, F. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Estrella, G.-T. and Cabrero, D.M. and Trent, R.J.A. and McCusker, E. and Novelletto, A. and Frontali, M. and Paulsen, J.S. and Jones, R. and Zanko, A. and Ashizawa, T. and Lazzarini, A. and Li, J.-L. and Wheeler, V.C. and Russ, A.L. and Xu, G. and Mysore, J.S. and Gillis, T. and Hakky, M. and Cupples, L.A. and Saint-Hilaire, M. and Hersch, S.M.
DOI: 10.1111/j.1469-1809.2006.00335.x
2007

Predictors of diagnosis in Huntington disease
Neurology
Langbehn, D.R. and Paulsen, J.S. and Hedges, P. and McCusker, E. and Pearce, S. and Trent, R. and Abwender, D. and Como, P. and Gardiner, I. and Hickey, C. and Kayson, E. and Kieburtz, K. and Marshall, F. and Pearson, N. and Shoulson, I. and Zimmerman, C. and Louis, E. and Marder, K. and Moskowitz, C. and Polanco, C. and Taylor, S. and Zubin, N. and Brown, C. and Burke-Holder, J. and Guttman, M. and Russell, S. and Stewart, D. and Thomson, J. and Sax, D.S. and Saint-Hilaire, M. and Gray, J. and Hunter, C. and Mercado, N. and Siemers, E. and Wojcieszek, J. and Dawson, T. and Leritz, E. and Rosenblatt, A. and Sherr, M. and Young, C. and Ashizawa, T. and Beach, J. and Jankovic, J. and Jaglin, J. and Shannon, K. and Lundin, A. and Francis, K. and Lane, K. and Auchus, A. and Greenamyre, J.T. and Hersch, S. and Jones, R. and Olson, D. and Cha, J.-H.J. and Cudkowicz, M. and Koroshetz, W. and Rudolf, G. and Sexton, P. and Young, A.B. and Albin, R. and Wernette, K. and Higgins, D.S. and Reider, C. and Hunt, V. and Walker, F. and Hauser, R. and Sanchez-Ramos, J. and Walker, A. and Nance, M. and Cleary, S. and Rohs, G. and Suchowersky, O. and Duncan, K. and Seeberger, L. and Corey-Bloom, J. and Swenson, M. and Swerdlow, N. and Paulson, H. and Rodnitzky, R. and Vining, L. and Martin, W. and Wieler, M. and Facca, A. and Rey, G. and Weiner, W. and Adler, C. and Caviness, J. and Lied, C. and Newman, S. and Feigin, A. and Mazurkiewicz, J. and Caplan, K. and Cellar, J. and Marek, K. and Hayden, M. and Raymond, L. and Dure, L.S. and Lane, J. and Brown, D. and Factor, S. and Molho, E. and Harrison, M. and Manning, C. and Rost-Ruffner, E. and Adams, J. and Cummings, R. and Wheelock, V. and Dubinsky, R. and Gray, C. and Catherine Bachoud-Levi, A. and Meierkord, H. and Friedman, J. and Lannon, M. and Lawrence, J. and Rubin, A. and Schwarz, R. and Brocht, A. and Claude, K. and Goldstein, J. and McDermott, M. and Oakes, D.
DOI: 10.1212/01.wnl.0000261918.90053.96
2007

Evaluation of recombinant AAV1 produced in insect cells for muscle-directed gene transfer
Human Gene Therapy
Twisk, Jaap and Ross, Colin J. D. and Comijn, Lizzy and Biesmans, Dennis and Haast, Saskia and Bakker, Andrew C. and Van Amersfoort, Edwin S. and Van Deventer, Sander J. H. and Meulenberg, Janneke J. M. and Hayden, Michael R. and Hermens, Wim T.
2007

Beyond disgust: Impaired recognition of negative emotions prior to diagnosis in Huntington's disease
Brain
Johnson, S.A. and Stout, J.C. and Solomon, A.C. and Langbehn, D.R. and Aylward, E.H. and Cruce, C.B. and Ross, C.A. and Nance, M. and Kayson, E. and Julian-Baros, E. and Hayden, M.R. and Kieburtz, K. and Guttman, M. and Oakes, D. and Shoulson, I. and Beglinger, L. and Duff, K. and Penziner, E. and Paulsen, J.S.
DOI: 10.1093/brain/awm107
2007

When good drugs go bad
Nature
Giacomini, K.M. and Krauss, R.M. and Roden, D.M. and Eichelbaum, M. and Hayden, M.R. and Nakamura, Y.
DOI: 10.1038/446975a
2007

Testicular degeneration in Huntington disease
Neurobiology of Disease
Van Raamsdonk, J.M. and Murphy, Z. and Selva, D.M. and Hamidizadeh, R. and Pearson, J. and Petersén, ?. and Björkqvist, M. and Muir, C. and Mackenzie, I.R. and Hammond, G.L. and Vogl, A.W. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1016/j.nbd.2007.01.006
2007

Spontanous atherosclerosis in old LPL-Deficient mice with severe hypertriglyceridemia on a normal chow diet
Arteriosclerosis Thrombosis and Vascular Biology
Zhang, Xiaohong and Qi, Rong and Xian, Xunde and Huang, Wei and Fan, Jianglin and Ross, Colin and Hayden, Michael R. and Liu, George
2007

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-ß peptide levels in vivo
Journal of Lipid Research
Hirsch-Reinshagen, V. and Chan, J.Y. and Wilkinson, A. and Tanaka, T. and Fan, J. and Ou, G. and Maia, L.F. and Singaraja, R.R. and Hayden, M.R. and Wellington, C.L.
DOI: 10.1194/jlr.M600543-JLR200
2007

Pharmacogenomics and its implications for autoimmune disease
Journal of Autoimmunity
Ross, C.J.D. and Katzov, H. and Carleton, B. and Hayden, M.R.
DOI: 10.1016/j.jaut.2007.02.008
2007

Lessons learned on the design of a pharmacogenomic study
Pharmacoepidemiology and Drug Safety
Dube, Marie-Pierre and Aeschliman, Dana S. and Carleton, Bruce C. and Hayden, Michael R.
2007

Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice
Arteriosclerosis, Thrombosis, and Vascular Biology
Wang, J. and Xian, X. and Huang, W. and Chen, L. and Wu, L. and Zhu, Y. and Fan, J. and Ross, C. and Hayden, M.R. and Liu, G.
DOI: 10.1161/01.ATV.0000249683.80414.d9
2007

Canadian national active surveillance network for adverse drug reactions: Genotypic approaches to therapy in children (GATC): The first year
Pharmacoepidemiology and Drug Safety
Carleton, B. C. and Warn, D. and Stenton, S. and Rassekh, R. and Smith, M. A. and Dhami, B. and Ross, C. and Hayden, M. R.
2007

Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1^-/- mice
Molecular Reproduction and Development
Khatchadourian, K. and Smith, C.E. and Metzler, M. and Gregory, M. and Hayden, M.R. and Cyr, D.G. and Hermo, L.
DOI: 10.1002/mrd.20564
2007

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
Neurobiology of Disease
Van Raamsdonk, J.M. and Metzler, M. and Slow, E. and Pearson, J. and Schwab, C. and Carroll, J. and Graham, R.K. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1016/j.nbd.2006.12.010
2007

Mycophenolate mofetil and atherosclerosis: Results of animal and human studies
Annals of the New York Academy of Sciences
DOI: 10.1196/annals.1423.023
2007

Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease
Neuroscience
Benn, C.L. and Slow, E.J. and Farrell, L.A. and Graham, R. and Deng, Y. and Hayden, M.R. and Cha, J.-H.J.
DOI: 10.1016/j.neuroscience.2007.03.010
2007

Chapter 15 Juvenile amyotrophic lateral sclerosis
Handbook of Clinical Neurology
Orban, P. and Devon, R.S. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1016/S0072-9752(07)80018-2
2007

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease
Journal of Neuroscience
Fan, M.M.Y. and Fernandes, H.B. and Zhang, L.Y.J. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1523/JNEUROSCI.4356-06.2007
2007

Selective degeneration in YAC mouse models of Huntington disease
Brain Research Bulletin
Van Raamsdonk, J.M. and Warby, S.C. and Hayden, M.R.
DOI: 10.1016/j.brainresbull.2006.10.018
2007

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease
Journal of Neuroscience
Fernandes, H.B. and Baimbridge, K.G. and Church, J. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1523/JNEUROSCI.3455-07.2007
2007

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations
Clinical Genetics
Goldberg, Y.P. and Macfarlane, J. and Macdonald, M.L. and Thompson, J. and Dube, M.P. and Mattice, M. and Fraser, R. and Young, C. and Hossain, S. and Pape, T. and Payne, B. and Radomski, C. and Donaldson, G. and Ives, E. and Cox, J. and Younghusband, H.B. and Green, R. and Duff, A. and Boltshauser, E. and Grinspan, G.A. and Dimon, J.H. and Sibley, B.G. and Andria, G. and Toscano, E. and Kerdraon, J. and Bowsher, D. and Pimstone, S.N. and Samuels, M.E. and Sherrington, R. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.2007.00790.x
2007

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease
Cell Cycle
Ratovitski, T. and Nakamura, M. and D'Ambola, J. and Chighladze, E. and Liang, Y. and Wang, W. and Graham, R. and Hayden, M.R. and Borchelt, D.R. and Hirschhorn, R.R. and Ross, C.A.
DOI: 10.4161/cc.6.23.4992
2007

Erratum: Predictive testing for Huntington disease: Interpretation and significance of intermediate alleles (Clinical Genetics (2006) vol. 70 (283-294))
Clinical Genetics
Semaka, A. and Creighton, S. and Warby, S. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.2007.00744.x
2007

CAG-encoded polyglutamine length polymorphism in the human genome
BMC Genomics
Butland, S.L. and Devon, R.S. and Huang, Y. and Mead, C.-L. and Meynert, A.M. and Neal, S.J. and Lee, S.S. and Wilkinson, A. and Yang, G.S. and Yuen, M.M.S. and Hayden, M.R. and Holt, R.A. and Leavitt, B.R. and Ouellete, B.F.F.
DOI: 10.1186/1471-2164-8-126
2007

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
Human Molecular Genetics
Kuhn, A. and Goldstein, D.R. and Hodges, A. and Strand, A.D. and Sengstag, T. and Kooperberg, C. and Becanovic, K. and Pouladi, M.A. and Sathasivam, K. and Cha, J.-H.J. and Hannan, A.J. and Hayden, M.R. and Leavitt, B.R. and Dunnett, S.B. and Ferrante, R.J. and Albin, R. and Shelbourne, P. and Delorenzi, M. and Augood, S.J. and Faull, R.L.M. and Olson, J.M. and Bates, G.P. and Jones, L. and Luthi-Carter, R.
DOI: 10.1093/hmg/ddm133
2007

Verbal episodic memory declines prior to diagnosis in Huntington's disease
Neuropsychologia
Solomon, A.C. and Stout, J.C. and Johnson, S.A. and Langbehn, D.R. and Aylward, E.H. and Brandt, J. and Ross, C.A. and Beglinger, L. and Hayden, M.R. and Kieburtz, K. and Kayson, E. and Julian-Baros, E. and Duff, K. and Guttman, M. and Nance, M. and Oakes, D. and Shoulson, I. and Penziner, E. and Paulsen, J.S.
DOI: 10.1016/j.neuropsychologia.2006.12.015
2007

Predictive testing for Huntington disease: interpretation and significance of intermediate alleles. (vol 70, pg 283, 2006)
Clinical Genetics
Semaka, A. and Creighton, S. and Warby, S. and Hayden, M. R.
2007

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1
Journal of Neuroscience
Metzler, M. and Gan, L. and Tak, P.W. and Liu, L. and Helm, J. and Liu, L. and Georgiou, J. and Wang, Y. and Bissada, N. and Cheng, K. and Roder, J.C. and Yu, T.W. and Hayden, M.R.
DOI: 10.1523/JNEUROSCI.5175-06.2007
2007

Managing genetic discrimination: Strategies used by individuals found to have the Huntington disease mutation
Clinical Genetics
Bombard, Y. and Penziner, B. and Decolongon, J. and Klimek, M.L.N. and Creighton, S. and Suchowersky, O. and Guttman, M. and Paulsen, J.S. and Bottorff, J.L. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.2007.00770.x
2007

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity
Journal of Neuroscience
Parker, J.A. and Metzler, M. and Georgiou, J. and Mage, M. and Roder, J.C. and Rose, A.M. and Hayden, M.R. and Néri, C.
DOI: 10.1523/JNEUROSCI.1941-07.2007
2007

Genotypic approaches to therapy in children: A national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children
Annals of the New York Academy of Sciences
DOI: 10.1196/annals.1423.020
2007

Body weight is modulated by levels of full-length Huntingtin
Human Molecular Genetics
Van Raamsdonk, J.M. and Gibson, W.T. and Pearson, J. and Murphy, Z. and Lu, G. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1093/hmg/ddl072
2006

Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels
Circulation Research
Brunham, L.R. and Kruit, J.K. and Pape, T.D. and Parks, J.S. and Kuipers, F. and Hayden, M.R.
DOI: 10.1161/01.RES.0000244014.19589.8e
2006

Molecular Pathogenesis of Huntington's Disease: The Role of Excitotoxicity
Genetic Instabilities and Neurological Diseases
DOI: 10.1016/B978-012369462-1/50016-8
2006

Lipoprotein lipase S447X: A naturally occurring gain-of-function mutation
Arteriosclerosis, Thrombosis, and Vascular Biology
Rip, J. and Nierman, M.C. and Ross, C.J. and Jukema, J.W. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.G. and Kuivenhoven, J.A.
DOI: 10.1161/01.ATV.0000219283.10832.43
2006

Hippi is essential for node cilia assembly and Sonic hedgehog signaling
Developmental Biology
Houde, C. and Dickinson, R.J. and Houtzager, V.M. and Cullum, R. and Montpetit, R. and Metzler, M. and Simpson, E.M. and Roy, S. and Hayden, M.R. and Hoodless, P.A. and Nicholson, D.W.
DOI: 10.1016/j.ydbio.2006.09.001
2006

Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities
Proceedings of the National Academy of Sciences of the United States of America
Devon, R.S. and Orban, P.C. and Gerrow, K. and Barbieri, M.A. and Schwab, C. and Cao, L.P. and Helm, J.R. and Bissada, M. and Cruz-Aguado, R. and Davidson, T.-L. and Witmer, J. and Metzler, M. and Lam, C.K. and Tetzlaff, W. and Simpson, E.M. and McCaffery, J.M. and El-Husseini, A.E. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1073/pnas.0510197103
2006

Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?
Nature Clinical Practice Neurology
Leavitt, B.R. and Hayden, M.R.
DOI: 10.1038/ncpneuro0299
2006

Gene therapy with lipoprotein lipase variant S447X - Response
Arteriosclerosis Thrombosis and Vascular Biology
Ross, CJD and Twisk, J and Kuivenhoven, JA and Rip, J and Kastelein, JJ and Hayden, MR
2006

Critical role of ATP-binding cassette transporter a1 (ABCA1) in beta-cell function and glucose homeostasis
Circulation
Brunham, Liam and Pape, Terry and Soukhatcheva, Galina and Verchere, Bruce and Hayden, Michael R.
2006

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo
Circulation
Singaraja, R.R. and Van Eck, M. and Bissada, N. and Zimetti, F. and Collins, H.L. and Hildebrand, R.B. and Hayden, A. and Brunham, L.R. and Kang, M.H. and Fruchart, J.-C. and Van Berkel, T.J.C. and Parks, J.S. and Staels, B. and Rothblat, G.H. and Fiévet, C. and Hayden, M.R.
DOI: 10.1161/CIRCULATIONAHA.106.621433
2006

To be or not to be toxic: aggregations in Huntington and Alzheimer disease
Trends in Genetics
Slow, E.J. and Graham, R.K. and Hayden, M.R.
DOI: 10.1016/j.tig.2006.05.008
2006

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models
Neurobiology of Disease
Graham, R.K. and Slow, E.J. and Deng, Y. and Bissada, N. and Lu, G. and Pearson, J. and Shehadeh, J. and Leavitt, B.R. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1016/j.nbd.2005.08.007
2006

Both hepatic and extrahepatic ABCA1 are essential for the maintenance of plasma HDL-C levels in vivo
Atherosclerosis Supplements
Singaraja, R. R. and Van Eck, M. and Fievet, C. and Hayden, M. R.
DOI: 10.1016/S1567-5688(06)82182-3
2006

In response [5]
Arteriosclerosis, Thrombosis, and Vascular Biology
Ross, C.J.D. and Twisk, J. and Kuivenhoven, J.A. and Rip, J. and Kastelein, J.J. and Hayden, M.R.
DOI: 10.1161/01.ATV.0000203502.01793.8d
2006

Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: The HD MAPS study
BMC Medical Genetics
Li, J.-L. and Hayden, M.R. and Warby, S.C. and Durr, A. and Morrison, P.J. and Nance, M. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Squitieri, F. and Frati, L. and Gómez-Tortosa, E. and García, C.A. and Suchowersky, O. and Klimek, M.L. and Trent, R.J.A. and McCusker, E. and Novelletto, A. and Frontali, M. and Paulsen, J.S. and Jones, R. and Ashizawa, T. and Lazzarini, A. and Wheeler, V.C. and Prakash, R. and Xu, G. and Djoussé, L. and Mysore, J.S. and Gillis, T. and Hakky, M. and Cupples, L.A. and Saint-Hilaire, M.H. and Cha, J.-H.J. and Hersch, S.M. and Penney, J.B. and Harrison, M.B. and Perlman, S.L. and Zanko, A. and Abramson, R.K. and Lechich, A.J. and Duckett, A. and Marder, K. and Conneally, P.M. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.
DOI: 10.1186/1471-2350-7-71
2006

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant Aß in plasma
Neurobiology of Disease
Burgess, B.L. and McIsaac, S.A. and Naus, K.E. and Chan, J.Y. and Tansley, G.H.K. and Yang, J. and Miao, F. and Ross, C.J.D. and van Eck, M. and Hayden, M.R. and van Nostrand, W. and St. George-Hyslop, P. and Westaway, D. and Wellington, C.L.
DOI: 10.1016/j.nbd.2006.06.007
2006

Comparative assessment of seminal traits, ovarian responsiveness and in vitro fertilization in 15 domestic cat models of hereditary disease.
Biology of Reproduction
Magarey, Genevieve M. and Bond, Jennifer B. and Bateman, Helen L. and Haskins, Mark E. and Fyfe, John C. and Baker, Henry J. and Hayden, Michael R. and Ross, Colin J. and Lyons, Leslie A. and Swanson, William F.
2006

Hepatic ABCA1 is a key molecule in HDL cholesteryl ester metabolism in mice
Atherosclerosis Supplements
Brundert, M. and Singaraja, R. R. and Stahmer, B. and Parks, J. S. and Hayden, M. R. and Rinninger, F.
DOI: 10.1016/S1567-5688(06)80651-3
2006

Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia
Biochemical and Biophysical Research Communications
Zhao, T. and Guo, J. and Li, H. and Huang, W. and Xian, X. and Ross, C.J.D. and Hayden, M.R. and Wen, Z. and Liu, G.
DOI: 10.1016/j.bbrc.2006.01.067
2006

FASA-57 cDNA shares no homology with coding sequence of HD gene [1]
Journal of Reproductive Immunology
Warby, S. and MacDonald, M. and Butland, S. and Ouellette, F. and Hayden, M.
DOI: 10.1016/j.jri.2005.10.002
2006

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease
BMC Neuroscience
Van Raamsdonk, J.M. and Pearson, J. and Murphy, Z. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1186/1471-2202-7-80
2006

The genotype-phenotype correlation of hereditary multiple exostoses
Clinical Genetics
Alvarez, C. and Tredwell, S. and De Vera, M. and Hayden, M.
DOI: 10.1111/j.1399-0004.2006.00653.x
2006

Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro
Circulation Research
Singaraja, R.R. and Visscher, H. and James, E.R. and Chroni, A. and Coutinho, J.M. and Brunham, L.R. and Kang, M.H. and Zannis, V.I. and Chimini, G. and Hayden, M.R.
DOI: 10.1161/01.RES.0000237920.70451.ad
2006

Selective deficiency of hepatic ABCA1 results in increased susceptibility to atherosclerosis
Circulation
Brunham, Liam and Timmins, Jenelle M. and Pape, Terry D. and Duong, MyNgan and Parks, John S. and Hayden, Michael R.
2006

Predictive testing for Huntington disease: Interpretation and significance of intermediate alleles
Clinical Genetics
Semaka, A. and Creighton, S. and Warby, S. and Hayden, M.A.
DOI: 10.1111/j.1399-0004.2006.00668.x
2006

Palmitoylation of huntingtin by HIP14is essential for its trafficking and function
Nature Neuroscience
Yanai, A. and Huang, K. and Kang, R. and Singaraja, R.R. and Arstikaitis, P. and Gan, L. and Orban, P.C. and Mullard, A. and Cowan, C.M. and Raymond, L.A. and Drisdel, R.C. and Green, W.N. and Ravikumar, B. and Rubinsztein, D.C. and El-Husseini, A. and Hayden, M.R.
DOI: 10.1038/nn1702
2006

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
Journal of Clinical Investigation
Brunham, L.R. and Kruit, J.K. and Iqbal, J. and Fievet, C. and Timmins, J.M. and Pape, T.D. and Coburn, B.A. and Bissada, N. and Staels, B. and Groen, A.K. and Hussain, M.M. and Parks, J.S. and Kuipers, F. and Hayden, M.R.
DOI: 10.1172/JCI27352
2006

Huntingtin inhibits caspase-3 activation
EMBO Journal
Zhang, Y. and Leavitt, B.R. and Van Raamsdonk, J.M. and Dragatsis, I. and Goldowitz, D. and MacDonald, M.E. and Hayden, M.R. and Friedlander, R.M.
DOI: 10.1038/sj.emboj.7601445
2006

Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin
Cell
Graham, R.K. and Deng, Y. and Slow, E.J. and Haigh, B. and Bissada, N. and Lu, G. and Pearson, J. and Shehadeh, J. and Bertram, L. and Murphy, Z. and Warby, S.C. and Doty, C.N. and Roy, S. and Wellington, C.L. and Leavitt, B.R. and Raymond, L.A. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1016/j.cell.2006.04.026
2006

Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease [4]
Clinical Genetics
Björkqvist, M. and Petersén, ?. and Carroll, J. and Nielsen, J. and Ecker, D. and Mulder, H. and Hayden, M.R. and Landwehrmeyer, B. and Brundin, P. and Leavitt, B.R.
DOI: 10.1111/j.1399-0004.2006.00636.x
2006

A gene therapy approach to treat human lipoprotein lipase deficiency
Atherosclerosis Supplements
Nierman, M. C. and Stroes, E. S. and Twisk, J. and Rip, J. and Dijkhuizen, P. and Ross, C. J. D. and Bakker, A. C. and Hermens, W. T. and Meulenberg, J. M. and Hayden, M. R. and Kastelein, J. J. P. and Kuivenhoven, J. A.
DOI: 10.1016/S1567-5688(06)80052-8
2006

Testicular degeneration in Huntington's disease
Movement Disorders
Leavitt, B. R. and Van Raamsdonk, J. M. and Murphy, Z. and Vogl, A. and Mackenzie, L. and Petersen, A. and Bjorkqvist, M. and Muir, C. and Hayden, M. R.
2006

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
Neurobiology of Disease
Shehadeh, J. and Fernandes, H.B. and Zeron Mullins, M.M. and Graham, R.K. and Leavitt, B.R. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1016/j.nbd.2005.08.001
2006

Mycophenolate mofetil and animal models
Lupus
Gibson, W.T. and Hayden, M.R.
DOI: 10.1177/0961203306071675
2006

Mycophenolate mofetil (MMF): Firing at the atherosclerotic plaque from different angles?
Cardiovascular Research
Van Leuven, S.I. and Kastelein, J.J.P. and Allison, A.C. and Hayden, M.R. and Stroes, E.S.G.
DOI: 10.1016/j.cardiores.2005.09.018
2006

Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH
Proceedings of the National Academy of Sciences of the United States of America
Bae, B.-I. and Hara, M.R. and Cascio, M.B. and Wellington, C.L. and Hayden, M.R. and Ross, C.A. and Ha, H.C. and Li, X.-J. and Snyder, S.H. and Sawa, A.
DOI: 10.1073/pnas.0511316103
2006

Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice
Arteriosclerosis, Thrombosis, and Vascular Biology
Singaraja, R.R. and Stahmer, B. and Brundert, M. and Merkel, M. and Heeren, J. and Bissada, N. and Kang, M. and Timmins, J.M. and Ramakrishnan, R. and Parks, J.S. and Hayden, M.R. and Rinninger, F.
DOI: 10.1161/01.ATV.0000229219.13757.a2
2006

Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation
Human Gene Therapy
Ross, C.J.D. and Twisk, J. and Bakker, A.C. and Miao, F. and Verbart, D. and Rip, J. and Godbey, T. and Dijkhuizen, P. and Hermens, W.T.J.M.C. and Kastelein, J.J.P. and Kuivenhoven, J.A. and Meulenberg, J.M. and Hayden, M.R.
DOI: 10.1089/hum.2006.17.487
2006

Wild-type huntingtin protects neurons from excitotoxicity
Journal of Neurochemistry
Leavitt, B.R. and Van Raamsdonk, J.M. and Shehadeh, J. and Fernandes, H. and Murphy, Z. and Graham, R.K. and Wellington, C.L. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1111/j.1471-4159.2005.03605.x
2006

Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.
Annual review of nutrition
Brunham, L.R. and Singaraja, R.R. and Hayden, M.R.
DOI: 10.1146/annurev.nutr.26.061505.111214
2006

Preparing for preventive clinical trials: The predict-HD study
Archives of Neurology
Paulsen, J.S. and Hayden, M. and Stout, J.C. and Langbehn, D.R. and Aylward, E. and Ross, C.A. and Guttman, M. and Nance, M. and Kieburtz, K. and Oakes, D. and Shoulson, I. and Kayson, E. and Johnson, S. and Penziner, E.
DOI: 10.1001/archneur.63.6.883
2006

Mycophenolate mofetil as an immunomodulatory silver bullet in atherogenesis?
Lupus
Van Leuven, S.I. and Kastelein, J.J.P. and Hayden, M.R. and Stroes, E.S.
DOI: 10.1177/0961203306071670
2006

Mitochondrial-dependent Ca²⁺ handling in Huntington's disease striatal cells: Effect of histone deacetylase inhibitors
Journal of Neuroscience
Oliveira, J.M.A. and Chen, S. and Almeida, S. and Riley, R. and Gon?alves, J. and Oliveira, C.R. and Hayden, M.R. and Nicholls, D.G. and Ellerby, L.M. and Rego, A.C.
DOI: 10.1523/JNEUROSCI.3004-06.2006
2006

Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice
Arteriosclerosis, Thrombosis, and Vascular Biology
Van Eck, M. and Singaraja, R.R. and Ye, D. and Hildebrand, R.B. and James, E.R. and Hayden, M.R. and Van Berkel, T.J.C.
DOI: 10.1161/01.ATV.0000208364.22732.16
2006

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
Neurobiology of Disease
Guidetti, P. and Bates, G.P. and Graham, R.K. and Hayden, M.R. and Leavitt, B.R. and MacDonald, M.E. and Slow, E.J. and Wheeler, V.C. and Woodman, B. and Schwarcz, R.
DOI: 10.1016/j.nbd.2006.02.011
2006

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease
Neurobiology of Disease
Kishikawa, S. and Li, J.-L. and Gillis, T. and Hakky, M.M. and Warby, S. and Hayden, M. and MacDonald, M.E. and Myers, R.H. and Gusella, J.F.
DOI: 10.1016/j.nbd.2006.07.008
2006

Ethyl-EPA in Huntington's disease: A double blind, randomised, placebo controlled trial
Journal of Neurology Neurosurgery and Psychiatry
Murck, H and Manku, M and Puri, BK and Leavitt, BR and Hayden, MR and Ross, CA and Rosenblatt, A and Greenamyre, JT and Hersch, S and Vaddadi, KS
2005

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease
Human Molecular Genetics
Van Raamsdonk, J.M. and Murphy, Z. and Slow, E.J. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1093/hmg/ddi407
2005

Selective degeneration and nuclear localisation of mutant huntingtin in the YAC128 mouse model of Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Van Raamsdonk, JM and Murphy, Z and Slow, EJ and Leavitt, BR and Hayden, MR
2005

Links between proteolysis and neurotoxicity identify novel approaches for modifying the pathogenesis of Huntington's disease
Journal of Neurology Neurosurgery and Psychiatry
Graham, RK and Yanai, A and El Husseini, A and Hayden, MR
2005

Histone acetylation and recovery from excitotoxicity in striatal cells expressing full length mutant huntingtin
Journal of Neurology Neurosurgery and Psychiatry
Oliveira, JM and Chen, SF and Almeida, S and Riley, R and Goncalves, J and Oliveira, CR and Hayden, MR and Nicholls, DG and Ellerby, LM and Rego, AC
2005

Gene therapy for lipoprotein lipase deficiency: Working toward clinical application
Human Gene Therapy
Rip, J. and Nierman, M.C. and Sierts, J.A. and Petersen, W. and Van Den Oever, K. and Van Raalte, D. and Ross, C.J.D. and Hayden, M.R. and Bakker, A.C. and Dijkhuizen, P. and Hermens, W.T. and Twisk, J. and Stroes, E. and Kastelein, J.J.P. and Kuivenhoven, J.A. and Meulenberg, J.M.
DOI: 10.1089/hum.2005.16.1276
2005

Experimental models of Huntington's disease
Drug Discovery Today: Disease Models
Van Raamsdonk, J.M. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1016/j.ddmod.2005.11.010
2005

Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease
Journal of Neurochemistry
Jenkins, B.G. and Andreassen, O.A. and Dedeoglu, A. and Leavitt, B. and Hayden, M. and Borchelt, D. and Ross, C.A. and Ferrante, R.J. and Beal, M.F.
DOI: 10.1111/j.1471-4159.2005.03411.x
2005

Complete functional rescue of the ABCA^1-/- mouse by human BAC transgenesis
Journal of Lipid Research
Coutinho, J.M. and Singaraja, R.R. and Kang, M. and Arenillas, D.J. and Bertram, L.N. and Bissada, N. and Staels, B. and Fruchart, J.-C. and Fievet, C. and Joseph-George, A.M. and Wasserman, W.W. and Hayden, M.R.
DOI: 10.1194/jlr.M400506-JLR200
2005

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
Journal of Biological Chemistry
Hirsch-Reinshagen, V. and Maia, L.F. and Burgess, B.L. and Blain, J.-F. and Naus, K.E. and McIsaac, S.A. and Parkinson, P.F. and Chan, J.Y. and Tansley, G.H. and Hayden, M.R. and Poirier, J. and Van Nostrand, W. and Wellington, C.L.
DOI: 10.1074/jbc.M508781200
2005

MR spectroscopy shows metabolic changes in transgenic Huntington's disease mice
Nordic Journal of Psychiatry
Andreassen, OA and Jenkins, BG and Kuesterman, E and Dedeoglu, A and Hayden, MR and Ross, CA and Borchelt, DR and Beal, MF
2005

Huntingtin Interacting Protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain
Journal of Biological Chemistry
Legendre-Guillemin, V. and Metzler, M. and Lemaire, J.-F. and Philie, J. and Gan, L. and Hayden, M.R. and McPherson, P.S.
DOI: 10.1074/jbc.M408430200
2005

HOXA7 protein expression in human normal ovary
Journal of the Society for Gynecologic Investigation
Ota, T. and Kwok, A. and Choi, K. B. and Pang, L. and Gilks, B. and Jefferies, W. A. and Hayden, M. R. and Leung, P. C. K. and Auersperg, N.
2005

Essential role of ABCA1 in HDL catabolism in mice
Arteriosclerosis Thrombosis and Vascular Biology
Rinninger, F. and Brundert, M. and Merkel, M. and Heeren, J. and Hayden, M. and Singaraja, R.
2005

Cardiovascular disease in systemic lupus erythematosus: Has the time for action come?
Current Opinion in Lipidology
Van Leuven, S.I. and Kastelein, J.J.P. and Hayden, M.R. and D'Cruz, D. and Hughes, G.R. and Stroes, E.S.
DOI: 10.1097/01.mol.0000182533.19135.cb
2005

Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene
PLoS Genetics
Brunham, L.R. and Singaraja, R.R. and Pape, T.D. and Kejariwal, A. and Thomas, P.D. and Hayden, M.R.
DOI: 10.1371/journal.pgen.0010083
2005

W10 regulation of plasma HDL levels and metabolism
Atherosclerosis Supplements
Van Berkel, T. and Out, R. and Hoekstra, M. and Hildebrand, R. B. and Kruijt, K. and Singaraja, R. and Kaminski, W. E. and Schmitz, G. and Hayden, M. and Van Eck, M.
DOI: 10.1016/s1567-5688(05)80183-7
2005

Tissue specific deletion of enterocyte ABCA1 identifies the intestine as a significant source of plasma HDL cholesterol in vivo
Arteriosclerosis Thrombosis and Vascular Biology
Brunham, LR and Pape, TD and Flevet, C and Timmins, JM and Bissada, N and Coburn, BA and Staels, B and Parks, JS and Hayden, MR
2005

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease
Human Molecular Genetics
Van Raamsdonk, J.M. and Pearson, J. and Rogers, D.A. and Bissada, N. and Vogl, A.W. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1093/hmg/ddi147
2005

From genes to therapies: AAV-mediated gene therapy for LPL deficiency
Circulation
Ross, CJ and Twisk, J and Rip, J and Nierman, MC and Dijkhuizen, P and Hermens, WT and Meulenberg, JM and Kastelein, JJ and Kuivenhoven, JA and Hayden, MR
2005

Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPL^S447X beneficial mutation
Arteriosclerosis, Thrombosis, and Vascular Biology
Ross, C.J.D. and Liu, G. and Kuivenhoven, J.A. and Twisk, J. and Rip, J. and Van Dop, W. and Excoffon, K.J.D.A. and Lewis, S.M.E. and Kastelein, J.J. and Hayden, M.R.
DOI: 10.1161/01.ATV.0000176971.27302.b0
2005

Ethyl-EPA in Huntington disease: A double-blind, randomized, placebo-controlled trial
Neurology
Puri, B.K. and Leavitt, B.R. and Hayden, M.R. and Ross, C.A. and Rosenblatt, A. and Greenamyre, J.T. and Hersch, S. and Vaddadi, K.S. and Sword, A. and Horrobin, D.F. and Manku, M. and Murck, H.
DOI: 10.1212/01.wnl.0000169025.09670.6d
2005

Disturbed Ca²⁺ signalling and apoptosis of medium spiny neurons in Huntington's disease
Proceedings of the National Academy of Sciences of the United States of America
Tang, T.-S. and Slow, E. and Lupu, V. and Stavrovskaya, I.G. and Sugimori, M. and Llinás, R. and Kristal, B.S. and Hayden, M.R. and Bezprozvanny, I.
DOI: 10.1073/pnas.0409402102
2005

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood
Neurobiology of Disease
Devon, R.S. and Schwab, C. and Topp, J.D. and Orban, P.C. and Yang, Y.-Z. and Pape, T.D. and Helm, J.R. and Davidson, T.-L. and Rogers, D.A. and Gros-Louis, F. and Rouleau, G. and Horazdovsky, B.F. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1016/j.nbd.2004.10.002
2005

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease
Journal of Neuroscience
Van Raamsdonk, J.M. and Pearson, J. and Slow, E.J. and Hossain, S.M. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1523/JNEUROSCI.0590-05.2005
2005

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
Proceedings of the National Academy of Sciences of the United States of America
Slow, E.J. and Graham, R.K. and Osmand, A.P. and Devon, R.S. and Lu, G. and Deng, Y. and Pearson, J. and Vaid, K. and Bissada, N. and Wetzel, R. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1073/pnas.0503634102
2005

Transglutaminases in Huntington disease (HD)
Journal of Neurochemistry
Cooper, AJ and Krasnikov, BF and Pinto, JT and Van Raamsdonk, JM and Hayden, MR and Leavitt, BR and Jeitner, TM
2005

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
Journal of Clinical Investigation
Timmins, J.M. and Lee, J.-Y. and Boudyguina, E. and Kluckman, K.D. and Brunham, L.R. and Mulya, A. and Gebre, A.K. and Coutinho, J.M. and Colvin, P.L. and Smith, T.L. and Hayden, M.R. and Maeda, N. and Parks, J.S.
DOI: 10.1172/JCI200523915
2005

Psychosocial effects of predictive testing for Huntington's disease.
Advances in neurology
Hayden, M.R. and Bombard, Y.
2005

Huntington's disease: Lessons for ChAc
Movement Disorders
Hayden, MR
2005

Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1
Journal of Lipid Research
Singaraja, R.R. and James, E.R. and Crim, J. and Visscher, H. and Chatterjee, A. and Hayden, M.R.
DOI: 10.1194/jlr.M500133-JLR200
2005

Increased expression of ABCA1 provides significant protection against atherosclerosis
Circulation
Singaraja, RR and Fievet, C and Bissada, N and Kang, M and McManus, B and Staels, B and Hayden, MR
2005

Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: Implications for the treatment of Huntington disease
Journal of Neurochemistry
Pinto, J.T. and Van Raamsdonk, J.M. and Leavitt, B.R. and Hayden, M.R. and Jeitner, T.M. and Thaler, H.T. and Krasnikov, B.F. and Cooper, A.J.L.
DOI: 10.1111/j.1471-4159.2005.03255.x
2005

Introduction to Social and Behavioural Research in genetics
Clinical Genetics
Hayden, M.R. and Biesecker, B.
DOI: 10.1111/j.1399-0004.2005.00464.x
2005

Intestinal ABCA1 is a significant contributor to plasma HDL-C and apoB levels in vivo
Circulation
Brunham, L and Kruit, JK and Pape, TD and Havinga, R and Flevet, C and Timmins, JM and Bissada, N and Staels, B and Groen, AK and Parks, JS and Kuipers, F and Hayden, MR
2005

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo
Human Molecular Genetics
Warby, S.C. and Chan, E.Y. and Metzler, M. and Gan, L. and Singaraja, R.R. and Crocker, S.F. and Robertson, H.A. and Hayden, M.R.
DOI: 10.1093/hmg/ddi165
2005

Huntingtin associates with acidic phospholipids at the plasma membrane
Journal of Biological Chemistry
Kegel, K.B. and Sapp, E. and Yoder, J. and Cuiffo, B. and Sobin, L. and Kim, Y.J. and Qin, Z.-H. and Hayden, M.R. and Aronin, N. and Scott, D.L. and Isenberg, G. and Goldmann, W.H. and DiFiglia, M.
DOI: 10.1074/jbc.M503672200
2005

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease
Journal of Neurochemistry
Van Raamsdonk, J.M. and Pearson, J. and Bailey, C.D.C. and Rogers, D.A. and Johnson, G.V.W. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1111/j.1471-4159.2005.03357.x
2005

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease
Experimental Neurology
Van Raamsdonk, J.M. and Pearson, J. and Rogers, D.A. and Lu, G. and Barakauskas, V.E. and Barr, A.M. and Honer, W.G. and Hayden, M.R. and Leavitt, B.R.
DOI: 10.1016/j.expneurol.2005.07.021
2005

A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis
Clinical Genetics
Delatycki, M.B. and Allen, K.J. and Gow, P. and MacFarlane, J. and Radomski, C. and Thompson, J. and Hayden, M.R. and Goldberg, Y.P. and Samuels, M.E.
DOI: 10.1111/j.0009-9163.2004.00254.x
2004

The contribution of hepatic adenosine triphosphate-binding cassette transporter, ABCA1, to high-density lipoprotein cholesterol levels in vivo.
Journal of Investigative Medicine
Brunham, LR and Wellington, CL and Orban, PC and Deng, Y and Hayden, MR
2004

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility
Journal of Lipid Research
Selva, D.M. and Hirsch-Reinshagen, V. and Burgess, B. and Zhou, S. and Chan, J. and McIsaac, S. and Hayden, M.R. and Hammond, G.L. and Vogl, A.W. and Wellington, C.L.
DOI: 10.1194/jlr.M400007-JLR200
2004

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
Cell Death and Differentiation
Hermel, E. and Gafni, J. and Propp, S.S. and Leavitt, B.R. and Wellington, C.L. and Young, J.E. and Hackam, A.S. and Logvinova, A.V. and Peel, A.L. and Chen, S.F. and Hook, V. and Singaraja, R. and Krajewski, S. and Goldsmith, P.C. and Ellerby, H.M. and Hayden, M.R. and Bredesen, D.E. and Ellerby, L.M.
DOI: 10.1038/sj.cdd.4401358
2004

HDL deficiency and atherosclerosis: Lessons from Tangier disease [1]
Journal of Internal Medicine
Hovingh, G.K. and Kuivenhoven, J.A. and Bisoendial, R.J. and Groen, A.K. and Van Dam, M. and Van Tol, A. and Wellington, C. and Hayden, M.R. and Smelt, A.H.M. and Kastelein, J.J.P.
DOI: 10.1046/j.0954-6820.2003.01256.x
2004

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease
Journal of Neurophysiology
Li, L. and Murphy, T.H. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1152/jn.00308.2004
2004

Correction of dyslipidemia in murine and feline models of lipoprotein lipase deficiency by intramuscular administration of AAV1-LPLS447X
Molecular Therapy
Ross, CJD and Twisk, J and Kuivenhoven, JA and Liu, GQ and Miao, FD and van den Oever, K and Beetz, M and Verbart, D and Bakker, A and Oranje, PPA and Hermens, WT and Dijkhuizen, P and Kastelein, JJP and Meulenberg, JJM and Hayden, MR
2004

ABCA1-mediated lipid transport from both the liver and the periphery are essential for maintenance of plasma HDL levels in vivo
Circulation
Singaraja, RR and Coutinho, JM and Ross, C and Bissada, N and Kang, MH and Brunham, LR and Timmins, JM and Miao, F and Parks, JS and Hayden, MR
2004

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length
Clinical Genetics
Langbehn, D.R. and Brinkman, R.R. and Falush, D. and Paulsen, J.S. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.2004.00241.x
2004

The endocytic protein HIP1 influences NMDAR function
Molecular Biology of the Cell
Metzler, M and Gan, L and Wong, TP and Liu, L and Helm, J and Wang, YS and Wang, YT and Hayden, MR
2004

Mutations in LCAT, ApoA-I, and ABCA1 can be distinguished by NMR lipoprotein subphenotyping
Arteriosclerosis Thrombosis and Vascular Biology
Brownlie, A and Hovingh, GK and Coutinho, J and Dube, MP and Klerkx, AH and Otvos, JD and Ludwig, EH and Kastelein, JJ and Hayden, MR and Kuivenhoven, JA
2004

Humanized transgenic ABCA1 mice show complete functional rescue of mouse ABCA1 deficiency
Arteriosclerosis Thrombosis and Vascular Biology
Coutinho, J and Singaraja, R and Kang, M and Fievet, C and Hayden, MR
2004

HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca²⁺ release in primary culture of striatal medium spiny neurons
European Journal of Neuroscience
Tang, T.-S. and Tu, H. and Orban, P.C. and Chan, E.Y.W. and Hayden, M.R. and Bezprozvanny, I.
DOI: 10.1111/j.1460-9568.2004.03633.x
2004

Tissue-specific hepatic deletion of ABCA1 indicates that the liver is the primary site of HDL formation in vivo
Arteriosclerosis Thrombosis and Vascular Biology
Timmins, JM and Lee, JY and Mulya, A and Kluckman, K and Brunham, LR and Hayden, MR and Maeda, N and Parks, JS
2004

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
Molecular and Cellular Biology
Trushina, E. and Dyer, R.B. and Badger II, J.D. and Ure, D. and Eide, L. and Tran, D.D. and Vrieze, B.T. and Legendre-Guillemin, V. and McPherson, P.S. and Mandavilli, B.S. and Van Houten, B. and Zeitlin, S. and McNiven, M. and Aebersold, R. and Hayden, M. and Parisi, J.E. and Seeberg, E. and Dragatsis, I. and Doyle, K. and Bender, A. and Chacko, C. and McMurray, C.T.
DOI: 10.1128/MCB.24.18.8195-8209.2004
2004

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice
Experimental Neurology
Zala, D. and Bensadoun, J.-C. and De Almeida, L.P. and Leavitt, B.R. and Gutekunst, C.-A. and Aebischer, P. and Hayden, M.R. and Déglon, N.
DOI: 10.1016/j.expneurol.2003.09.002
2004

Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: A marker of cardiac dilatation
Molecular and Cellular Biochemistry
Reddy, HK and Tjahja, IE and Campbell, SE and Janicki, JS and Hayden, MR and Tyagi, SC
DOI: 10.1023/B:MCBI.0000044387.04670.81
2004

Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16
Neurogenetics
Djoussé, L. and Knowlton, B. and Hayden, M.R. and Almqvist, E.W. and Brinkman, R.R. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Durr, A. and Dode, C. and Morrison, P.J. and Novelletto, A. and Frontali, M. and Trent, R.J.A. and McCusker, E. and Gómez-Tortosa, E. and Cabrero, D.M. and Jones, R. and Zanko, A. and Nance, M. and Abramson, R.K. and Suchowersky, O. and Paulsen, J.S. and Harrison, M.B. and Yang, Q. and Cupples, L.A. and Mysore, J. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.
DOI: 10.1007/s10048-004-0175-2
2004

A case of tangier disease with a novel mutation in the C-terminal region of ATP-binding cassette transporter A1
American Journal of Medical Genetics
Guan, J.-Z. and Tamasawa, N. and Brunham, L.R. and Matsui, J. and Murakami, H. and Suda, T. and Ochiai, S. and Tsutsui, M. and Kudou, K. and Satoh, K. and Hayden, M.R.
DOI: 10.1002/ajmg.a.30284
2004

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease
Molecular and Cellular Neuroscience
Zeron, M.M. and Fernandes, H.B. and Krebs, C. and Shehadeh, J. and Wellington, C.L. and Leavitt, B.R. and Baimbridge, K.G. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1016/j.mcn.2003.11.014
2004

Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPL^S447X beneficial mutation
Human Gene Therapy
Ross, C.J.D. and Twisk, J. and Meulenberg, J.M. and Liu, G. and Van Den Oever, K. and Moraal, E. and Hermens, W.T. and Rip, J. and Kastelein, J.J.P. and Kuivenhoven, J.A. and Hayden, M.R.
DOI: 10.1089/hum.2004.15.906
2004

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
Nature
Saleh, M. and Vaillancourt, J.P. and Graham, R.K. and Huyck, M. and Srinivasula, S.M. and Alnemri, E.S. and Steinberg, M.H. and Holan, V. and Baldwin, C.T. and Hotchkiss, R.S. and Buchman, T.G. and Zehnbauer, B.A. and Hayden, M.R. and Farrer, L.A. and Roy, S. and Nicholson, D.W.
DOI: 10.1038/nature02451
2004

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length (vol 65, pg 267, 2004)
Clinical Genetics
Langbehn, DR and Brinkman, RR and Falush, D and Paulsen, JS and Hayden, MR and Int Huntingtons Dis Collaborative
DOI: 10.1111/j.1399-0004.2004.00299.x
2004

Identification of a Novel Gene (HSN2) Causing Hereditary Sensory and Autonomic Neuropathy Type II through the Study of Canadian Genetic Isolates
American Journal of Human Genetics
Lafrenière, R.G. and MacDonald, M.L.E. and Dubé, M.-P. and MacFarlane, J. and O'Driscoll, M. and Brais, B. and Meilleur, S. and Brinkman, R.R. and Dadivas, O. and Pape, T. and Platon, C. and Radomski, C. and Risler, J. and Thompson, J. and Guerra-Escobio, A.-M. and Davar, G. and Breakefield, X.O. and Pimstone, S.N. and Green, R. and Pryse-Phillips, W. and Goldberg, Y.P. and Younghusband, H.B. and Hayden, M.R. and Sherrington, R. and Rouleau, G.A. and Samuels, M.E.
DOI: 10.1086/420795
2004

Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins
Neuron
Huang, K. and Yanai, A. and Kang, R. and Arstikaitis, P. and Singaraja, R.R. and Metzler, M. and Mullard, A. and Haigh, B. and Gauthier-Campbell, C. and Gutekunst, C.-A. and Hayden, M.R. and El-Husseini, A.
DOI: 10.1016/j.neuron.2004.11.027
2004

Genetic testing and Huntington's disease: Issues of employment
Lancet Neurology
Harper, P.S. and Gevers, S. and De Wert, G. and Creighton, S. and Bombard, Y. and Hayden, M.R.
DOI: 10.1016/S1474-4422(04)00711-2
2004

ABCA1 modulates APOE levels in brain and plasma
Neurobiology of Aging
Hirsch-Reinshagen, V. and Zhou, S. and Chan, J. and McIsaac, S. and Cohn, J. and Hayden, M. and Wellington, C.
DOI: 10.1016/s0197-4580(04)80050-2
2004

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease
Journal of the American College of Cardiology
Hovingh, G.K. and Brownlie, A. and Bisoendial, R.J. and Dube, M.P. and Levels, J.H.M. and Petersen, W. and Dullaart, R.P.F. and Stroes, E.S.G. and Zwinderman, A.H. and De Groot, E. and Hayden, M.R. and Kuivenhoven, J.A. and Kastelein, J.J.P.
DOI: 10.1016/j.jacc.2004.06.070
2004

Huntington's disease-like 2 (HDL2) in North America and Japan
Annals of Neurology
Margolis, R.L. and Holmes, S.E. and Rosenblatt, A. and Gourley, L. and O'Hearn, E. and Ross, C.A. and Seltzer, W.K. and Walker, R.H. and Ashizawa, T. and Rasmussen, A. and Hayden, M. and Almqvist, E.W. and Harris, J. and Fahn, S. and MacDonald, M.E. and Mysore, J. and Shimohata, T. and Tsuji, S. and Potter, N. and Nakaso, K. and Adachi, Y. and Nakashima, K. and Bird, T. and Krause, A. and Greenstein, P.
DOI: 10.1002/ana.20248
2004

Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction
Journal of Neuroscience
Qin, Z.-H. and Wang, Y. and Sapp, E. and Cuiffo, B. and Wanker, E. and Hayden, M.R. and Kegel, K.B. and Aronin, N. and DiFiglia, M.
DOI: 10.1523/JNEUROSCI.1409-03.2004
2004

Erratum: A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length (Clinical Genetics (2004) vol. 65 (267-277))
Clinical Genetics
Langbehn, D.R. and Brinkman, R.R. and Falush, D. and Paulsen, J.S. and Hayden, M.R.
DOI: 10.1111/j.0009-9163.2004.00299.x
2004

Deranged neuronal calcium signaling and Huntington disease
Biochemical and Biophysical Research Communications
Bezprozvanny, I. and Hayden, M.R.
DOI: 10.1016/j.bbrc.2004.08.035
2004

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
Journal of Biological Chemistry
Hirsch-Reinshagen, V. and Zhou, S. and Burgess, B.L. and Bernier, L. and McIsaac, S.A. and Chan, J.Y. and Tansley, G.H. and Cohn, J.S. and Hayden, M.R. and Wellington, C.L.
DOI: 10.1074/jbc.M407962200
2004

Palmitoylation of ABCA1 is required for its normal trafficking to the plasma membrane and for lipid efflux activity
Circulation
Singaraja, RR and Kang, MH and Coutinho, JM and Arstikaitis, P and El Husseini, A and Hayden, MR
2004

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
Nature Genetics
Papanikolaou, G. and Samuels, M.E. and Ludwig, E.H. and MacDonald, M.L.E. and Franchini, P.L. and Dubé, M.-P. and Andres, L. and MacFarlane, J. and Sakellaropoulos, N. and Politou, M. and Nemeth, E. and Thompson, J. and Risler, J.K. and Zaborowska, C. and Babakaiff, R. and Radomski, C.C. and Pape, T.D. and Davidas, O. and Christakis, J. and Brissot, P. and Lockitch, G. and Ganz, T. and Hayden, M.R. and Goldberg, Y.P.
DOI: 10.1038/ng1274
2004

Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPLS447X beneficial mutation
Human Gene Therapy
Ross, CJD and Twisk, J and Meulenberg, JM and Liu, GQ and van den Oever, K and Moraal, E and Hermens, WT and Rip, J and Kastelein, JJP and Kuivenhoven, JA and Hayden, MR
DOI: 10.1089/1043034041839235
2004

Inhibition of calpain cleavage of Huntingtin reduces toxicity: Accumulation of calpain/caspase fragments in the nucleus
Journal of Biological Chemistry
Gafni, J. and Hermel, E. and Young, J.E. and Wellington, C.L. and Hayden, M.R. and Ellerby, L.M.
DOI: 10.1074/jbc.M401267200
2004

Erratum: Huntington's disease-like 2 (HDL2) in North America and Japan (Annals of Neurology (November 2004) 56 (670-674))
Annals of Neurology
Margolis, R.L. and Holmes, S.E. and Rosenblatt, A. and Gourley, L. and O'Hearn, E. and Ross, C.A. and Seltzer, W.K. and Walker, R.H. and Ashizawa, T. and Rasmussen, A. and Hayden, M. and Almqvist, E.W. and Harris, J. and Fahn, S. and MacDonald, M.E. and Mysore, J. and Shimohata, T. and Tsuji, S. and Potter, N. and Nakaso, K. and Adachi, Y. and Nakashima, K. and Bird, T. and Krause, A. and Greenstein, P.
DOI: 10.1002/ana.20349
2004

Clinical and radiographic features among presymptomatic individuals carrying an expanded CAG repeat in the Huntington's disease gene: Analysis of baseline characteristics of the PREDICT-HD cohort
Neurology
Ross, C. A. and Aylward, E. H. and Stout, J. C. and Biglan, K. M. and Hayden, M. R. and Shoulson, I. and Langbehn, D. R. and Paulsen, J. S. and Predict, H. D. Investigators H. S. D.
2004

A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study
American Journal of Human Genetics
Li, J.-L. and Hayden, M.R. and Almqvist, E.W. and Brinkman, R.R. and Durr, A. and Dodé, C. and Morrison, P.J. and Suchowersky, O. and Ross, C.A. and Margolis, R.L. and Rosenblatt, A. and Gómez-Tortosa, E. and Cabrero, D.M. and Novelletto, A. and Frontali, M. and Nance, M. and Trent, R.J.A. and McCusker, E. and Jones, R. and Paulsen, J.S. and Harrison, M. and Zanko, A. and Abramson, R.K. and Russ, A.L. and Knowlton, B. and Djoussé, L. and Mysore, J.S. and Tariot, S. and Gusella, M.F. and Wheeler, V.C. and Atwood, L.D. and Cupples, L.A. and Saint-Hilaire, M. and Cha, J.-H.J. and Hersch, S.M. and Koroshetz, W.J. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.
DOI: 10.1086/378133
2003

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
Human Molecular Genetics
Slow, E.J. and van Raamsdonk, J. and Rogers, D. and Coleman, S.H. and Graham, R.K. and Deng, Y. and Oh, R. and Bissada, N. and Hossain, S.M. and Yang, Y.-Z. and Li, X.-J. and Simpson, E.M. and Gutekunst, C.-A. and Leavitt, B.R. and Hayden, M.R.
DOI: 10.1093/hmg/ddg169
2003

Clarity is essential when using Nucleotide number systems
Atherosclerosis
Brunham, L.R. and Hayden, M.R.
DOI: 10.1016/S0021-9150(03)00234-X
2003

A genetic, biochemical and proteomic approach to dissection of inherited HDL phenotypes in humans
Atherosclerosis Supplements
Brownlie, A. and Ludwig, E. and Hovingh, K. and Van Wijland, M. and Bisoendial, R. and Klerkx, A. and Dube, M. P. and Samuels, M. and Groen, A. and Kastelein, J. and Hayden, M.
DOI: 10.1016/s1567-5688(03)90594-0
2003

Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein
Circulation
Bisoendial, R.J. and Hovingh, G.K. and Levels, J.H.M. and Lerch, P.G. and Andresen, I. and Hayden, M.R. and Kastelein, J.J.P. and Stroes, E.S.G.
DOI: 10.1161/01.CIR.0000070934.69310.1A
2003

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity
Journal of Biological Chemistry
Nucifora Jr., F.C. and Ellerby, L.M. and Wellington, C.L. and Wood, J.D. and Herring, W.J. and Sawa, A. and Hayden, M.R. and Dawson, V.L. and Dawson, T.M. and Ross, C.A.
DOI: 10.1074/jbc.M211224200
2003

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking
EMBO Journal
Metzler, M. and Li, B. and Gan, L. and Georgiou, J. and Gutekunst, C.-A. and Wang, Y. and Torre, E. and Devon, R.S. and Oh, R. and Legendre-Guillemin, V. and Rich, M. and Alvarez, C. and Gertsenstein, M. and McPhersons, P.S. and Nagy, A. and Wang, Y.T. and Roder, J.C. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1093/emboj/cdg334
2003

Biochemical characterization of mutations in ABCA1 correlate with disease severity
Atherosclerosis Supplements
Singaraja, R. and Visscher, H. and James, E. and Hayden, M.
DOI: 10.1016/s1567-5688(03)90587-3
2003

ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens
Journal of Biological Chemistry
Mulligan, J.D. and Flowers, M.T. and Tebon, A. and Bitgood, J.J. and Wellington, C. and Hayden, M.R. and Attie, A.D.
DOI: 10.1074/jbc.M212377200
2003

A novel CETP mutation (IVS7+1) in a family of Dutch descent with hyperalphalipoproteinemia
Circulation
Klerkx, AH and Hovingh, GK and Nootenboom, IC and Brownlie, AJ and van Tol, A and Hayden, MR and Kastelein, JJ and Kuivenhoven, JA
2003

Skewed X-chromosome inactivation is associated with trisomy in women ascertained on the basis of recurrent spontaneous abortion or chromosomally abnormal pregnancies
American Journal of Human Genetics
Beever, C.L. and Stephenson, M.D. and Peñaherrera, M.S. and Jiang, R.H. and Kalousek, D.K. and Hayden, M. and Field, L. and Brown, C.J. and Robinson, W.P.
DOI: 10.1086/346119
2003

Mutations in a novel gene cause hereditary sensory and autonomic neuropathy type II
American Journal of Human Genetics
Samuels, M. and Lafreniere, R. and MacDonald, M. and MacFarlane, J. and Dube, M. P. and O'Driscoll, M. and Meilleur, S. and Thompson, J. and Goldberg, Y. P. and Brais, B. and Pryse-Phillips, W. and Green, R. and Younghusband, B. and Hayden, M. and Sherrington, R. and Rouleau, G.
2003

Mutant frizzled-4 (FZD4) causes autosomal dominant familial exudative vitreoretinopathy (FEVR) with variable intrafamilial phenotype
Investigative Ophthalmology & Visual Science
Robitaille, JM and MacDonald, MLE and Guernsey, DL and Zheng, B and Siebert, LS and Hoskin-Mott, A and Beis, MJ and Hayden, MR and Goldberg, YP and Samuels, ME
2003

Macrophage ABCA1 overexpression inhibits atherosclerotic lesion progression
Atherosclerosis Supplements
Van Eck, M and Singaraja, RR and Hildebrand, RB and James, ER and Hayden, MR and Van Berkel, TJC
DOI: 10.1016/S1567-5688(03)90585-X
2003

Long-term correction of murine lipoprotein lipase (LPL) deficiency by a single intramuscular administration of AAV1-LPLS447X
Circulation
Ross, CJ and Twisk, J and Kuivenhoven, JA and Liu, GQG and Miao, F and Scheenhart-van der Meer, JW and Bakker, A and Moraal, E and Oranje, PP and Hermens, WT and Kastelein, JJ and Meulenberg, JJ and Hayden, MR
2003

Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease
American Journal of Medical Genetics
Djoussé, L. and Knowlton, B. and Hayden, M. and Almqvist, E.W. and Brinkman, R. and Ross, C. and Margolis, R. and Rosenblatt, A. and Durr, A. and Dode, C. and Morrison, P.J. and Novelletto, A. and Frontali, M. and Trent, R.J.A. and McCusker, E. and Gómez-Tortosa, E. and Mayo, D. and Jones, R. and Zanko, A. and Nance, M. and Abramson, R. and Suchowersky, O. and Paulsen, J. and Harrison, M. and Yang, Q. and Cupples, L.A. and Gusella, J.F. and MacDonald, M.E. and Myers, R.H.
DOI: 10.1002/ajmg.a.20190
2003

A novel apoA-I mutation (Leu178Pro), identified by whole genome linkage approach, predisposes to endothelial dysfunction, increased arterial wall thickness and premature coronary artery disease
Atherosclerosis Supplements
Hovingh, GK and Bisoendial, RJ and Brownlie, A and Samuels, M and Kuivenhoven, JA and De Groot, E and Stroes, ESG and Hayden, MR and Kastelein, JJP
DOI: 10.1016/S1567-5688(03)90113-9
2003

Restoration of endothelial function by increasing HDL in subjects with isolated low-HDL
Atherosclerosis Supplements
Bisoendial, RJ and Hovingh, GK and Levels, JHM and Lerch, PG and Andresen, I and Hayden, MR and Kastelein, JJP and Stroes, ESG
DOI: 10.1016/S1567-5688(03)91303-1
2003

Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease
Clinical Genetics
Almqvist, E.W. and Brinkman, R.R. and Wiggins, S. and Hayden, M.R. and Nicolson Klimek, M.L. and Trew, M. and Suchowersky, O. and Grover, S. and Bamforth, S. and Adam, S. and Huggins, M. and Bloch, M. and Green, T. and Greenberg, C. and Ives, E. and Fuller, A. and Welch, P. and Eisenberg, D. and Whelan, D. and Kane, J. and Soltan, H. and MacGregor, D. and Summers, A. and Meschino, W. and Prevost, C. and Dunfrasne, S. and Roy, M. and Rosenblatt, D. and Cardwell, S. and Gibson, A. and Shokeir, M.H.K.
DOI: 10.1034/j.1399-0004.2003.00157.x
2003

Preface
Clinical Neuroscience Research
Wellington, C.L. and Hayden, M.R.
DOI: 10.1016/S1566-2772(03)00053-7
2003

Predictive testing for persons at risk for homozygosity for CAG expansion in the Huntington disease gene [4]
Clinical Genetics
Squitieri, F. and Almqvist, E.W. and Cannella, M. and Cislaghi, G. and Hayden, M.R.
DOI: 10.1046/j.1399-0004.2003.00155.x
2003

Disruption of the endocytic protein HIP1 results in major neurological deficits and decreased AMPA receptor trafficking
American Journal of Human Genetics
Metzler, MM and Gan, L and Li, B and Georgiou, J and Gutekunst, CA and Wang, Y and Torre, E and Wang, YT and Roder, JC and Raymond, LA and Hayden, MR
2003

Depletion of wild-type huntingtin in mouse models of neurologic diseases
Journal of Neurochemistry
Zhang, Y. and Li, M. and Drozda, M. and Chen, M. and Ren, S. and Sanchez, R.O.M. and Leavitt, B.R. and Cattaneo, E. and Ferrante, R.J. and Hayden, M.R. and Friedlander, R.M.
DOI: 10.1046/j.1471-4159.2003.01980.x
2003

Working towards clinical application of gene therapy for LPL deficiency
Circulation
Rip, J and Nierman, MC and Sierts, JA and van Raalte, D and Petersen, W and van den Oever, K and Ross, CJ and Hayden, MR and Meulenberg, JM and Twisk, J and Kastelein, JJ and Kuivenhoven, JA
2003

Pro-survival effects of wild-type huntingtin in vivo.
American Journal of Human Genetics
Leavitt, BR and Rogers, D and van-Raamsdonk, J and Opina, CJ and Chan, E and Wellington, CL and Hayden, MR
2003

Mutation Screening of the ALS2 Gene in Sporadic and Familial Amyotrophic Lateral Sclerosis
Archives of Neurology
Hand, C.K. and Devon, R.S. and Gros-Louis, F. and Rochefort, D. and Khoris, J. and Meininger, V. and Bouchard, J.-P. and Camu, W. and Hayden, M.R. and Rouleau, G.A.
DOI: 10.1001/archneur.60.12.1768
2003

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Nature Genetics
Zuccato, C. and Tartari, M. and Crotti, A. and Goffredo, D. and Valenza, M. and Conti, L. and Cataudella, T. and Leavitt, B.R. and Hayden, M.R. and Timmusk, T. and Rigamonti, D. and Cattaneo, E.
DOI: 10.1038/ng1219
2003

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
Neuron
Tang, T.-S. and Tu, H. and Chan, E.Y.W. and Maximov, A. and Wang, Z. and Wellington, C.L. and Hayden, M.R. and Bezprozvanny, I.
DOI: 10.1016/S0896-6273(03)00366-0
2003

Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1
Journal of Lipid Research
Wellington, C.L. and Brunham, L.R. and Zhou, S. and Singaraja, R.R. and Visscher, H. and Gelfer, A. and Ross, C. and James, E. and Liu, G. and Huber, M.T. and Yang, Y.-Z. and Parks, R.J. and Groen, A. and Fruchart-Najib, J. and Hayden, M.R.
DOI: 10.1194/jlr.M300110-JLR200
2003

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia
Journal of Lipid Research
Hovingh, G.K. and Van Wijland, M.J.A. and Brownlie, A. and Bisoendial, R.J. and Hayden, M.R. and Kastelein, J.J.P. and Groen, A.K.
DOI: 10.1194/jlr.M300080-JLR200
2003

Mutations in the HFE2A gene cause juvenile hemochromatosis
American Journal of Human Genetics
Goldberg, P. and Papanikolaou, G. and Ludwig, E. and MacDonald, M. and Andres, L. and Dube, M. P. and Franchini, P. and Babakaiff, R. and Risler, J. and Zaborowska, C. and Pimstone, S. and Brissot, P. and Lockitch, G. and Hayden, M. and Samuels, M.
2003

Macrophage-specific ATP-Binding cassette transporter 1 (ABCA1) overexpression inhibits atherosclerotic lesion progression
Circulation
Van Eck, M and Singaraja, RR and Hildebrand, RB and James, ER and Hayden, MR and Van Berkel, TJ
2003

Huntington proteolysis in Huntington disease
Clinical Neuroscience Research
Wellington, C.L. and Ellerby, L.M. and Leavitt, B.R. and Roy, S. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1016/S1566-2772(03)00055-0
2003

Functional effects of tissue-specific expression of ATP-cassette transporter A1 (ABCA1) provide multiple mechanisms for protection against atherosclerosis
Atherosclerosis Supplements
Hayden, M. and Singaraja, R. and Van Eck, M. and Van Berkel, T. and Kastelein, J. J. P.
DOI: 10.1016/s1567-5688(03)91163-9
2003

Functional analysis of mutations in the ABCA1 gene
Journal of Investigative Medicine
Brunham, L. and Singaraja, R. and Visscher, H. and James, E. and Hayden, M.
2003

Distinct cellular and biochemical effects of specific mutations in ABCA1 predicts the phenotype in TD and FHA
American Journal of Human Genetics
Singaraja, R. and Visscher, H. and James, E. and Hayden, M.
2003

CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia
American Journal of Medical Genetics - Neuropsychiatric Genetics
Laurent, C. and Niehaus, D. and Bauché, S. and Levinson, D.F. and Soubigou, S. and Pimstone, S. and Hayden, M. and Mbanga, I. and Emsley, R. and Deleuze, J.-F. and Mallet, J.
DOI: 10.1002/ajmg.b.10797
2003

Allelic variation in the promoter region of the LDL receptor gene: Analysis of an African-specific variant in the FP2 cis-acting regulatory element
Molecular and Cellular Probes
Hoogendijk, C.F. and Scholtz, C.L. and Pimstone, S.M. and Ehrenborg, E. and Kastelein, J.J.P. and Defesche, J.C. and Thiart, R. and Du Plessis, L. and De Villiers, J.N.P. and Zaahl, M.G. and Delport, R. and Rubinsztein, D.C. and Raffel, L.J. and Grim, C.E. and Mediene-Benchekor, S. and Amouyel, P. and Brousseau, T. and Steyn, K. and Lombard, C.J. and Hayden, M.R. and Kotze, M.J.
DOI: 10.1016/S0890-8508(03)00050-1
2003

A novel apoAl mutation (Leu178Pro) leads to severely disturbed HDL metabolism, endothelial dysfunction, increased arterial wall thickness and premature coronary artery disease
Circulation
Hovingh, G. K. and Brownlie, A. and Bisoendial, R. J. and Kuivenhoven, J. A. and Levels, J. H. and Dube, M. and Stroes, E. S. and de Groot, E. and Hayden, M. R. and Kastelein, J. J.
2003

The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings
Clinical Genetics
Devon, R.S. and Helm, J.R. and Rouleau, G.A. and Leitner, Y. and Lerman-Sagie, T. and Lev, D. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.2003.00138.x
2003

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease
Neurobiology of Aging
DOI: 10.1016/j.neurobiolaging.2003.04.003
2003

Predictors of nursing home placement in Huntington disease
Neurology
Wheelock, V.L. and Tempkin, T. and Marder, K. and Nance, M. and Myers, R.H. and Zhao, H. and Kayson, E. and Orme, C. and Shoulson, I. and Hedges, P. and McCusker, E. and Pearce, S. and Trent, R. and Abwender, D. and Como, P. and Gardiner, I. and Hickey, C. and Kieburtz, K. and Marshall, F. and Pearson, N. and Zimmerman, C. and Louis, E. and Moskowitz, C. and Polanco, C. and Zubin, N. and Brown, C. and Burkeholder, J. and Guttman, M. and Russell, S. and Stewart, D. and Thomson, J. and Sax, D.S. and Saint-Hilaire, M. and Gray, J. and Hunter, C. and Mercado, N. and Siemers, E. and Wojeieszek, J. and Dawson, T. and Leritz, E. and Rosenblatt, A. and Sherr, M. and Young, C. and Ashizawa, T. and Beach, J. and Jankovic, J. and Jaglin, J. and Shannon, K. and Lundin, A. and Francis, K. and Lane, K. and Auchus, A. and Greenamyre, J.T. and Hersch, S. and Jones, R. and Olson, D. and Cha, J.-H.J. and Cudkowicz, M. and Koroshetz, W. and Penney, J. and Rudolf, G. and Sexton, P. and Young, A.B. and Albin, R. and Wernette, K. and Higgins, D.S. and Reider, C. and Hunt, V. and Walker, F. and Hauscr, R. and Sanchez-Ramos, J. and Walker, A. and Pantello, C. and Rohs, G. and Suchowersky, O. and Duncan, K. and Seeberger, L. and Corey-Bloom, J. and Paulsen, J. and Swenson, M. and Swerdlow, N. and Martin, W. and Wieler, M. and Facca, A. and Rey, G. and Weiner, W. and Adler, C. and Caviness, J. and Lied, C. and Newman, S. and Feigin, A. and Mazurkiewicz, J. and Caplan, K. and Cellar, J. and Marck, K. and Hayden, M. and Raymond, L. and Dure, L.S. and Lane, J.
DOI: 10.1212/01.WNL.0000052992.58107.67
2003

Predictive testing for Huntington's disease: A universal model?
Lancet Neurology
Hayden, M.R.
DOI: 10.1016/S1474-4422(03)00317-X
2003

Long-term correction of murine lipoprotein lipase deficiency by single intramuscular administration of AAV1-LPLS447X
Molecular Therapy
Ross, CJD and Meulenberg, JJM and Twisk, J and Kuivenhoven, JA and Liu, GQG and Miao, FD and Moraal, E and Oranje, PPA and Bakker, A and Hermens, WTJMC and Scheenhart-van der Meer, JJW and Kastelein, JJP and Hayden, MR
2003

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course
Brain
Squitieri, F. and Gellera, C. and Cannella, M. and Mariotti, C. and Cislaghi, G. and Rubinsztein, D.C. and Almqvist, E.W. and Turner, D. and Bachoud-Lévi, A.-C. and Simpson, S.A. and Delatycki, M. and Maglione, V. and Hayden, M.R. and Di Donato, S.
DOI: 10.1093/brain/awg077
2003

Dosage effects of riluzole in Huntington's disease - A multicenter placebo-controlled study
Neurology
Marshall, F. J. and Cudkowicz, M. and Hayden, M. and Kieburtz, K. and Zhao, H. W. and Penney, J. and Dure, L. and Lane, J. and Raymond, L. and Decolongon, J. and Marder, K. and Moskowitz, C. and Dubinsky, R. and Gray, C. and Nance, M. and Radtke, D. and Feigin, A. and Shannon, B. and Higgins, D. and Baic, C. and Shannon, K. and Jaglin, J. and Hauser, R. and Delgado, H. and Almqvist, E. W. and de Blieck, E. A. and Biglan, K. and Hogarth, P. and Brocht, A. and Chadwick, C. and Daigneault, S. and Donaghue, P. and Josephson, L. and Shinaman, A. and Slough, M. and Weaver, C. and Bourgeois, K. and Oakes, D. and Watts, A. and Huntington Study, Grp
2003

Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: The experience in Canada from 1987 to 2000
Clinical Genetics
Creighton, S. and Almqvist, E.W. and MacGregor, D. and Fernandez, B. and Hogg, H. and Beis, J. and Welch, J.P. and Riddell, C. and Lokkesmoe, R. and Khalifa, M. and MacKenzie, J. and Sajoo, A. and Farrell, S. and Robert, F. and Shugar, A. and Summers, A. and Meschino, W. and Allingham-Hawkins, D. and Chiu, T. and Hunter, A. and Allanson, J. and Hare, H. and Schween, J. and Collins, L. and Sanders, S. and Greenberg, C. and Cardwell, S. and Lemire, E. and MacLeod, P. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.2003.00093.x
2003

Heterozygosity for ABCA1 gene mutations: Effects on enzymes, apolipoproteins and lipoprotein particle size
Atherosclerosis
Kuivenhoven, J.A. and Hovingh, G.K. and Van Tol, A. and Jauhiainen, M. and Ehnholm, C. and Fruchart, J.C. and Brinton, E.A. and Otvos, J.D. and Smelt, A.H.M. and Brownlee, A. and Zwinderman, A.H. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1016/j.atherosclerosis.2003.08.014
2003

Efflux and atherosclerosis: The clinical and biochemical impact of variations in the ABCA1 gene
Arteriosclerosis, Thrombosis, and Vascular Biology
Singaraja, R.R. and Brunham, L.R. and Visscher, H. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1161/01.ATV.0000078520.89539.77
2003

Caudate volume as an outcome measure in clinical trials for Huntington's disease: A pilot study
Brain Research Bulletin
Aylward, E.H. and Rosenblatt, A. and Field, K. and Yallapragada, V. and Kieburtz, K. and McDermott, M. and Raymond, L.A. and Almqvist, E.W. and Hayden, M. and Ross, C.A.
DOI: 10.1016/j.brainresbull.2003.09.005
2003

An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred [2]
Annals of Neurology
Gros-Louis, F. and Meijer, I.A. and Hand, C.K. and Dubé, M.-P. and MacGregor, D.L. and Seni, M.-H. and Devon, R.S. and Hayden, M.R. and Andermann, F. and Andermann, E. and Rouleau, G.A.
DOI: 10.1002/ana.10422
2003

A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding
Journal of Biological Chemistry
Hussain, N.K. and Yamabhai, M. and Bhakar, A.L. and Metzler, M. and Ferguson, S.S.G. and Hayden, M.R. and McPherson, P.S. and Kay, B.K.
DOI: 10.1074/jbc.M300995200
2003

A genome scan for modifiers of age at onset in Huntington's disease: The HD MAPS study
American Journal of Human Genetics
Li, J. L. and Hayden, M. and Almqvist, E. W. and Durr, A. and Dod, C. and Morrison, P. J. and Suchowersky, O. and Ross, C. A. and Margolis, R. L. and Gmez-Tortosa, E. and Mayo, D. and Novelletto, A. and Nance, M. and Trent, R. J. A. and Zanko, A. and Abramson, R. K. and Russ, A. L. and Gusella, J. F. and MacDonald, M. E. and Myers, R. H.
2003

Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency
Biochemical and Biophysical Research Communications
Nishida, Y. and Hirano, K.-I. and Tsukamoto, K. and Nagano, M. and Ikegami, C. and Zhang, Z. and Tsujii, K.-I. and Matsuyama, A. and Ohama, T. and Matsuura, F. and Ishigami, M. and Sakai, N. and Hiraoka, H. and Yamashita, S. and Matsuzawa, Y. and Nagano, M. and Ishihara, M. and Hattori, H. and Egashira, T. and Sakane, N. and Yoshida, Y. and Roomp, K. and Wellington, C. and Hayden, M.R. and Misugi, S.
DOI: 10.1006/bbrc.2001.6219
2002

Skewed XCl in women experiencing a pregnancy with meiotic nondisjunction.
American Journal of Human Genetics
Penaherrera, MS and Beever, CL and Jiang, RH and McFadden, DE and Hayden, MR and Field, LL and Kalousek, DK and Brown, CJ and Robinson, WP
2002

Nuclear localization of a truncation product of mutant atrophin-1, increases cellular toxicity
Molecular Biology of the Cell
Nucifora, FC and Wood, JD and Ellerby, LM and Herring, WJ and Sawa, A and Wellington, CL and Hayden, MR and Dawson, VL and Dawson, TM and Ross, CA
2002

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
Neuron
Zeron, M.M. and Hansson, O. and Chen, N. and Wellington, C.L. and Leavitt, B.R. and Brundin, P. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1016/S0896-6273(02)00615-3
2002

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease
Human Molecular Genetics
Chan, E.Y.W. and Luthi-Carter, R. and Strand, A. and Solano, S.M. and Hanson, S.A. and DeJohn, M.M. and Kooperberg, C. and Chase, K.O. and DiFiglia, M. and Young, A.B. and Leavitt, B.R. and Cha, J.-H.J. and Aronin, N. and Hayden, M.R. and Olson, J.M.
DOI: 10.1093/hmg/11.17.1939
2002

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain
Journal of Biological Chemistry
Legendre-Guillemin, V. and Metzler, M. and Charbonneau, M. and Gan, L. and Chopra, V. and Philie, J. and Hayden, M.R. and McPherson, P.S.
DOI: 10.1074/jbc.M112310200
2002

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol
Journal of Lipid Research
Wellington, C.L. and Yang, Y.-Z. and Zhou, S. and Clee, S.M. and Tan, B. and Hirano, K. and Zwarts, K. and Kwok, A. and Gelfer, A. and Marcil, M. and Newman, S. and Roomp, K. and Singaraja, R. and Collins, J. and Zhang, L.-H. and Groen, A.K. and Hovingh, K. and Brownlie, A. and Tafuri, S. and Genest Jr., J. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1194/jlr.M200277-JLR200
2002

Striatal neurochemical changes in transgenic models of Huntington's disease
Journal of Neuroscience Research
Ariano, M.A. and Aronin, N. and Difiglia, M. and Tagle, D.A. and Sibley, D.R. and Leavitt, B.R. and Hayden, M.R. and Levine, M.S.
DOI: 10.1002/jnr.10272
2002

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: An observational study
Lancet
Van Dam, M.J. and De Groot, E. and Clee, S.M. and Hovingh, G.K. and Roelants, R. and Brooks-Wilson, A. and Zwinderman, A.H. and Smit, A.J. and Smelt, A.H.M. and Groen, A.K. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1016/S0140-6736(02)07277-X
2002

Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux
Journal of Biological Chemistry
See, R.H. and Caday-Malcolm, R.A. and Singaraja, R.R. and Zhou, S. and Silverston, A. and Huber, M.T. and Moran, J. and James, E.R. and Janoo, R. and Savill, J.M. and Rigot, V. and Zhang, L.-H. and Wang, M. and Chimini, G. and Wellington, C.L. and Tafuri, S.R. and Hayden, M.R.
DOI: 10.1074/jbc.M204923200
2002

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Nature Neuroscience
Panov, A.V. and Gutekunst, C.-A. and Leavitt, B.R. and Hayden, M.R. and Burke, J.R. and Strittmatter, W.J. and Greenamyre, J.T.
DOI: 10.1038/nn884
2002

A whole genome linkage approach leads to successful identification of a novel apoA1 mutation causing five percent of familial high-density lipoprotein deficiency in the Dutch population
Circulation
Brownlie, AJ and Hovingh, GK and Kuivenhoven, JA and Dube, MP and Verschoof, H and Samuels, M and Kastelein, JJP and Hayden, MR
2002

A whole genome linkage approach identifies a novel ApoA1 mutation causing five percent of familial hypoalphalipoproteinemia in the Dutch population.
American Journal of Human Genetics
Samuels, M and Hovingh, GK and Kuivenhoven, JA and Dube, MP and Verschoof, H and Goldberg, YP and Kastelein, JJP and Hayden, MR and Brownlie, A
2002

Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken
Journal of Lipid Research
Attie, A.D. and Hamon, Y. and Brooks-Wilson, A.R. and Gray-Keller, M.P. and MacDonald, M.L.E. and Rigot, V. and Tebon, A. and Zhang, L.-H. and Mulligan, J.D. and Singaraja, R.R. and James Bitgood, J. and Cook, M.E. and Kastelein, J.J.P. and Chimini, G. and Hayden, M.R.
DOI: 10.1194/jlr.M200223-JLR200
2002

PKA site-specific phosphorylation of ABCA1 regulates ApoA-1-dependent phospholipid efflux
Circulation
See, RH and Caday-Malcolm, RA and Singaraja, RR and Zhou, S and Silverston, A and Huber, MT and Moran, J and James, ER and Janoo, R and Zhang, LH and Wang, MH and Wellington, CL and Tafuri, SR and Hayden, MR
2002

Phenotypic description of hereditary sensory neuropathy type 1A (HSN 1A) in two kindreds segregating the same mutation in the gene encoding serine palmitoyl transferase long chain subunit
American Journal of Human Genetics
O'Driscoll, MP and Ainsworth, P and Bieger, D and Goldberg, YP and Green, RC and Hahn, AF and Khani-Hanjani, A and Hayden, MR and MacFarlanes, J and Pryse-Phillips, W and Samuels, M and Younghusband, HB
2002

Increased ABCA1 activity protects against atherosclerosis
Journal of Clinical Investigation
Singaraja, R.R. and Fievet, C. and Castro, G. and James, E.R. and Hennuyer, N. and Clee, S.M. and Bissada, N. and Choy, J.C. and Fruchart, J.-C. and McManus, B.M. and Staels, B. and Hayden, M.L.R.
DOI: 10.1172/JCI0215748
2002

Frizzled-4 mutations disrupt retinal angiogenesis in familial exudative vitreoretinopathy (FEVR)
American Journal of Human Genetics
MacDonald, MLE and Robitaille, J and Kaykas, A and Sheldahl, L and Dube, MP and Guernsey, D and Zheng, B and Siebert, L and Hoskin-Mott, A and Pimstone, SN and Shastry, BS and Moon, RT and Hayden, MR and Goldberg, YP and Samuels, ME
2002

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
Journal of Neuroscience
Wellington, C.L. and Ellerby, L.M. and Gutekunst, C.-A. and Rogers, D. and Warby, S. and Graham, R.K. and Loubser, O. and Van Raamsdonk, J. and Singaraja, R. and Yang, Y.-Z. and Gafni, J. and Bredesen, D. and Hersch, S.M. and Leavitt, B.R. and Roy, S. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1523/jneurosci.22-18-07862.2002
2002

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation
Laboratory Investigation
Wellington, C.L. and Walker, E.K.Y. and Suarez, A. and Kwok, A. and Bissada, N. and Singaraja, R. and Yang, Y.-Z. and Zhang, L.-H. and James, E. and Wilson, J.E. and Francone, O. and McManus, B.M. and Hayden, M.R.
DOI: 10.1038/labinvest.3780421
2002

Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior
Human Molecular Genetics
Chan, E.Y.W. and Nasir, J. and Gutekunst, C.-A. and Coleman, S. and Maclean, A. and Maas, A. and Metzler, M. and Gertsenstein, M. and Ross, C.A. and Nagy, A. and Hayden, M.R.
DOI: 10.1093/hmg/11.8.945
2002

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
Journal of Lipid Research
Attie, A.D. and Krauss, R.M. and Gray-Keller, M.P. and Brownlie, A. and Miyazaki, M. and Kastelein, J.J. and Lusis, A.J. and Stalenhoef, A.F.H. and Stoehr, J.P. and Hayden, M.R. and Ntambi, J.M.
DOI: 10.1194/jlr.M200189-JLR200
2002

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
Nature Cell Biology
Gervais, F.G. and Singaraja, R. and Xanthoudakis, S. and Gutekunst, C.-A. and Leavitt, B.R. and Metzler, M. and Hackam, A.S. and Tam, J. and Vaillancourt, J.P. and Houtzager, V. and Rasper, D.M. and Roy, S. and Hayden, M.R. and Nicholson, D.W.
DOI: 10.1038/ncb735
2002

Proteomics of clathrin-coated vesicles: Identification of novel endocytic proteins
Faseb Journal
McPherson, PS and Legendre-Guillemin, V and Metzler, M and Hayden, MR and Bell, AW and Wasiak, S
2002

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
Nature Genetics
Robitaille, J. and MacDonald, M.L.E. and Kaykas, A. and Sheldahl, L.C. and Zeisler, J. and Dubé, M.-P. and Zhang, L.-H. and Singaraja, R.R. and Guernsey, D.L. and Zheng, B. and Siebert, L.F. and Hoskin-Mott, A. and Trese, M.T. and Pimstone, S.N. and Shastry, B.S. and Moon, R.T. and Hayden, M.R. and Paul Goldberg, Y. and Samuels, M.E.
DOI: 10.1038/ng957
2002

Increased HDL and changes in lipoprotein composition are associated with increased efflux and atheroprotection in an ABCA1 BAC transgenic mouse model
Circulation
Singaraja, RR and Fievet, C and Castro, G and James, E and Clee, S and Hennuyer, N and Choy, J and Bissada, N and McManus, B and Staels, B and Hayden, MR
2002

ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels
Clinical Genetics
Zwarts, K.Y. and Clee, S.M. and Zwinderman, A.H. and Engert, J.C. and Singaraja, R. and Loubser, O. and James, E. and Roomp, K. and Hudson, T.J. and Jukema, J.W. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.2002.610206.x
2002

Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene
Journal of Lipid Research
Peterson, J. and Ayyobi, A.F. and Yuanhong, M. and Henderson, H. and Reina, M. and Deeb, S.S. and Santamarina-Fojo, S. and Hayden, M.R. and Brunzell, J.D.
2002

Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract
Nature Genetics
Bu, L. and Jin, Y. and Shi, Y. and Chu, R. and Ban, A. and Eiberg, H. and Andres, L. and Jiang, H. and Zheng, G. and Qian, M. and Cui, B. and Xia, Y. and Liu, J. and Hu, L. and Zhao, G. and Hayden, M.R. and Kong, X.
DOI: 10.1038/ng921
2002

Long-term efficacy of a single administration of AAV lipoprotein lipase gene therapy corrects murine hypertriglyceridemia and raises HDL
Circulation
Ross, CJD and Kuivenhoven, JA and Liu, GQG and Miao, F and Scheenhart-van der Meer, JWC and Moraal, E and Oranje, PPA and Hermens, WTJMC and Kastelein, JJP and Hayden, MR and Meulenberg, JJM
2002

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis
Human Molecular Genetics
Singaraja, R.R. and Hadano, S. and Metzler, M. and Givan, S. and Wellington, C.L. and Warby, S. and Yanai, A. and Gutekunst, C.-A. and Leavitt, B.R. and Yi, H. and Fichter, K. and Gan, L. and McCutcheon, K. and Chopra, V. and Michel, J. and Hersch, S.M. and Ikeda, J.-E. and Hayden, M.R.
DOI: 10.1093/hmg/11.23.2815
2002

HIP1 and HIP12 are interacting family members that display differential binding to clathrin, AP2 and F-actin
Molecular Biology of the Cell
Legendre-Guillemin, V and Metzler, MM and Charbonneau, M and Gan, L and Chopra, V and Kwok, A and Hayden, MR and McPherson, PS
2001

Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis
Journal of Lipid Research
Attie, AD and Kastelein, JP and Hayden, MR
2001

Onset and pre-onset studies to define the Huntington's disease natural history
Brain Research Bulletin
DOI: 10.1016/S0361-9230(01)00648-7
2001

Clinical markers of early disease in persons near onset of Huntington's disease
Neurology
Paulsen, J.S. and Zhao, H. and Stout, J.C. and Brinkman, R.R. and Guttman, M. and Ross, C.A. and Como, P. and Manning, C. and Hayden, M.R. and Shoulson, I.
DOI: 10.1212/WNL.57.4.658
2001

A one-hit model of cell death in inherited neuronal degenerations (vol 406, pg 195, 2000)
Nature
Clarke, G and Collins, RA and Leavitt, BR and Andrews, DF and Hayden, MR and Lumsden, CJ and McInnes, RR
2001

Pivotal role of ABCA1 in reverse cholesterol transport influencing HLD levels and susceptibility to atherosclerosis
Journal of Lipid Research
Attie, A.D. and Kastelein, J.P. and Hayden, M.R.
2001

Modulation of cellular cholesterol efflux in fibroblasts by cAMP: Evidence of post-transcriptional regulation and phosphorylation of ABCA1 protein
Circulation
Haidar, B. and Denis, M. and Marcil, M. and Wellington, C. and Kastelein, J. and Hayden, M. and Genest, J.
2001

Maternal expression of functional lipoprotein lipase and effects on body fat mass and body condition scores of mature cats with lipoprotein lipase deficiency
American Journal of Veterinary Research
Backus, R.C. and Ginzinger, D.G. and Ashbourne Excoffon, K.J.D. and Clee, S.M. and Hayden, M.R. and Eckel, R.H. and Hickman, M.A. and Rogers, Q.R.
DOI: 10.2460/ajvr.2001.62.264
2001

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
Science
Zuccato, C. and Ciammola, A. and Rigamonti, D. and Leavitt, B.R. and Goffredo, D. and Conti, L. and MacDonald, M.E. and Friedlander, R.M. and Silani, V. and Hayden, M.R. and Timmusk, T. and Sipione, S. and Cattaneo, E.
DOI: 10.1126/science.1059581
2001

High incidence rate and absent family histories in one quarter of patients newly diagnosed with Huntington disease in British Columbia
Clinical Genetics
Almqvist, E.W. and Elterman, D.S. and MacLeod, P.M. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.2001.600305.x
2001

Common variants in the lipoprotein lipase gene play a significant role in the pathogenesis of HDL-C deficiency in men with coronary heart disease
Arteriosclerosis Thrombosis and Vascular Biology
Brousseau, ME and Goldkamp, AL and Collins, D and Connelly, A and Ordovas, JM and Hayden, MR and Robins, SJ and Rubins, HB and Schaefer, EJ
2001

Common mutations in the lipoprotein lipase gene (LPL): Effects on HDL-cholesterol levels in a Chinese Canadian population
Atherosclerosis
McGladdery, S.H. and Pimstone, S.N. and Clee, S.M. and Bowden, J.Francois and Hayden, M.R. and Frohlich, J.J.
DOI: 10.1016/S0021-9150(00)00670-5
2001

Increased HDL-C and apoA1 dependent efflux modulated by LXREs in human ABCA1 BAC transgenic mice
Circulation
Singaraja, R and Bocher, V and James, ER and Clee, SM and Zhang, LH and Brooks-Wilson, A and Kwok, A and Bissada, N and Yang, YZ and Liu, GQ and Wellington, CL and Fievet, C and Staels, B and Hayden, MR
2001

Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron
Journal of Biological Chemistry
Singaraja, R.R. and Bocher, V. and James, E.R. and Clee, S.M. and Zhang, L.-H. and Leavitt, B.R. and Tan, B. and Brooks-Wilson, A. and Kwok, A. and Bissada, N. and Yang, Y.-Z. and Liu, G. and Tafuri, S.R. and Fievet, C. and Wellington, C.L. and Staels, B. and Hayden, M.R.
DOI: 10.1074/jbc.M102503200
2001

Familial influence on age of onset among siblings with huntington disease
American Journal of Medical Genetics - Neuropsychiatric Genetics
Rosenblatt, A. and Brinkman, R.R. and Liang, K.Y. and Almqvist, E.W. and Margolis, R.L. and Huang, C.Y. and Sherr, M. and Franz, M.L. and Abbott, M.H. and Hayden, M.R. and Ross, C.A.
DOI: 10.1002/ajmg.1400
2001

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
Proceedings of the National Academy of Sciences of the United States of America
Parker, J.A. and Connolly, J.B. and Wellington, C. and Hayden, M. and Dausset, J. and Neri, C.
DOI: 10.1073/pnas.231476398
2001

Erratum: A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 (Nature Genetics (2001) 29 (166-173))
Nature Genetics
Hadano, S. and Hand, C.K. and Osuga, H. and Yanagisawa, Y. and Otomo, A. and Devon, R.S. and Miyamoto, N. and Showguchi-Miyata, J. and Okada, Y. and Singaraja, R. and Figlewicz, D.A. and Kwiatkowski, T. and Hosler, B.A. and Sagie, T. and Skaug, J. and Nasir, J. and Brown R.H., Jr. and Scherer, S.W. and Rouleau, G.A. and Hayden, M.R. and Ikeda, J.-E.
DOI: 10.1038/ng1101-352a
2001

ABCA1 regulatory variants influence coronary artery disease (CAD) independent of effects on plasma lipid levels.
Circulation
Clee, SM and Zwarts, KY and Zwinderman, AH and Engert, JC and Singaraja, R and Loubser, O and James, ER and Roomp, K and Hudson, TJ and Jukema, JW and Kastelein, JJP and Hayden, MR
2001

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 (vol 29, pg 166, 2001)
Nature Genetics
Hadano, S. and Hand, C. K. and Osuga, H. and Yanagisawa, Y. and Otomo, A. and Devon, R. S. and Miyamoto, N. and Showguchi-Miyata, J. and Okada, Y. and Singaraja, R. and Figlewicz, D. A. and Kwiatkowski, T. and Hosler, B. A. and Sagie, T. and Skaug, J. and Nasir, J. and Brown, R. H. and Scherer, S. W. and Rouleau, G. A. and Hayden, M. R. and Ikeda, J. E.
2001

Wild-type Huntingtin reduces the cellular toxicity of mutant Huntingtin in vivo
American Journal of Human Genetics
Leavitt, B.R. and Guttman, J.A. and Hodgson, J.G. and Kimel, G.H. and Singaraja, R. and Vogl, A.W. and Hayden, M.R.
DOI: 10.1086/318207
2001

The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease
Clinical Genetics
Clee, S.M. and Loubser, O. and Collins, J. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.2001.600407.x
2001

The factor structure for positive and negative symptoms in South African Xhosa patients with schizophrenia
Schizophrenia Research
Emsley, R.A. and Niehaus, D.J.H. and Mbanga, N.I. and Oosthuizen, P.P. and Stein, D.J. and Maritz, J.S. and Pimstone, S.N. and Hayden, M.R. and Laurent, C. and Deleuze, J.-F. and Mallet, J.
DOI: 10.1016/S0920-9964(00)00010-4
2001

The 'flap' endonuclease gene FEN1 is excluded as a candidate gene implicated in the CAG repeat expansion underlying Huntington disease
Clinical Genetics
Otto, C.J. and Almqvist, E. and Hayden, M. and Andrew, S.E.
DOI: 10.1034/j.1399-0004.2001.590210.x
2001

NMDA receptor function in mouse models of Huntington disease
Journal of Neuroscience Research
Cepeda, C. and Ariano, M.A. and Calvert, C.R. and Flores-Hernández, J. and Chandler B, S.H. and Leavitt, B.R. and Hayden, M.R. and Levine, M.S.
DOI: 10.1002/jnr.1244
2001

Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's diseases (HD) transcripts and is activated in HD tissue
Human Molecular Genetics
Peel, A.L. and Rao, R.V. and Cottrell, B.A. and Hayden, M.R. and Ellerby, L.M. and Bredesen, D.E.
2001

Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue
Human Molecular Genetics
Peel, AL and Rao, RV and Cottrell, BA and Hayden, MR and Ellerby, LM and Bredesen, DE
DOI: 10.1093/hmg/10.15.1531
2001

Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease
Circulation
Clee, S.M. and Zwinderman, A.H. and Engert, J.C. and Zwarts, K.Y. and Molhuizen, H.O.F. and Roomp, K. and Jukema, J.W. and Van Wijland, M. and Van Dam, M. and Hudson, T.J. and Brooks-Wilson, A. and Genest Jr., J. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1161/01.CIR.103.9.1198
2001

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
Nature Genetics
Hadano, S. and Hand, C.K. and Osuga, H. and Yanagisawa, Y. and Otomo, A. and Devon, R.S. and Miyamoto, N. and Showguchi-Miyata, J. and Okada, Y. and Singaraja, R. and Figlewicz, D.A. and Kwiatkowski, T. and Hosler, B.A. and Sagie, T. and Skaug, J. and Nasir, J. and Brown, R.H. and Scherer, S.W. and Rouleau, G.A. and Hayden, M.R. and Ikeda, J.-E.
DOI: 10.1038/ng1001-166
2001

HIP1 Functions in Clathrin-mediated Endocytosis through Binding to Clathrin and Adaptor Protein 2
Journal of Biological Chemistry
Metzler, M. and Legendre-Guillemin, V. and Gan, L. and Chopra, V. and Kwok, A. and McPherson, P.S. and Hayden, M.R.
DOI: 10.1074/jbc.C100401200
2001

Erratum: A one-hit model of cell death in inherited neuronal degenerations (Nature (2000) 406 (195-199))
Nature
Clarke, G. and Collins, R.A. and Leavitt, B.R. and Andrews, D.F. and Hayden, M.R. and Lumsden, C.J. and McInnes, R.R.
DOI: 10.1038/35054107
2001

Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: Candidate genes for ALS2
Genomics
Hadano, S. and Yanagisawa, Y. and Skaug, J. and Fichter, K. and Nasir, J. and Martindale, D. and Koop, B.F. and Scherer, S.W. and Nicholson, D.W. and Rouleau, G.A. and Ikeda, J.-E. and Hayden, M.R.
DOI: 10.1006/geno.2000.6392
2001

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis
Proceedings of the National Academy of Sciences of the United States of America
Holbert, S. and Denghien, I. and Kiechle, T. and Rosenblatt, A. and Wellington, C. and Hayden, M.R. and Margolis, R.L. and Ross, C.A. and Dausset, J. and Ferrante, R.J. and Néri, C.
DOI: 10.1073/pnas.98.4.1811
2001

Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases
American Journal of Human Genetics
Falush, D. and Almqvist, E.W. and Brinkmann, R.R. and Iwasa, Y. and Hayden, M.R.
DOI: 10.1086/318193
2001

Truncation mutations in human ABCA1 suppress normal upregulation of wild-type ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol
Circulation
Wellington, CL and Yang, YZ and Kwok, A and Clee, SM and Zwartz, K and Marcel, M and Newman, S and Roomp, K and Singaraja, R and Zhang, LH and Kastelein, JJP and Genest, J and Hayden, MR
2001

Mutant huntingtin enhances excitotoxic cell death
Molecular and Cellular Neuroscience
Zeron, M.M. and Chen, N. and Moshaver, A. and Ting-Chun Lee, A. and Wellington, C.L. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1006/mcne.2000.0909
2001

HIP1(-/-) mice develop a adult onset phenotype characterized by thoracolumbar kyphosis, alterations in synaptic plasticity and a defect in reproduction
Molecular Biology of the Cell
Metzler, MM and Georgiou, J and Gutekunst, CA and Oh, R and Gan, L and Rich, M and Roder, J and Hayden, MR
2001

cSNP analysis of the ABCA1 gene: the R219K variant is associated with a blunted age-modulated increase in HDL cholesterol and decreased coronary artery disease (CAD).
American Journal of Human Genetics
Molhuizen, HOF and Clee, SM and Zwinderman, AH and Engert, J and Zwarts, KY and Roomp, K and Brooks-Wilson, A and Hudson, T and Jukema, JW and Kastelein, JJP and Hayden, MR
2000

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency,Mutations du gene de l'ATP binding cassette-1 (ABC1) dans la maladie de Tangier et la deficience familiale en HDL
Medecine/Sciences
Marcil, M. and Genest Jr., J. and Brooks-Wilson, A. and Hayden, M. and Kastelein, J.
DOI: 10.4267/10608/1664
2000

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain
Journal of Biological Chemistry
Hackam, A.S. and Yassa, A.S. and Singaraja, R. and Metzler, M. and Gutekunst, C.-A. and Gan, L. and Warby, S. and Wellington, C.L. and Vaillancourt, J. and Chen, N. and Gervais, F.G. and Raymond, L. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1074/jbc.M008408200
2000

Caspases and neurodegeneration: On the cutting edge of new therapeutic approaches
Clinical Genetics
Wellington, C.L. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.2000.570101.x
2000

Wild-type huntingtin protects from apoptosis upstream of caspase-3
Journal of Neuroscience
Rigamonti, D. and Bauer, J.H. and De-Fraja, C. and Conti, L. and Sipione, S. and Sciorati, C. and Clementi, E. and Hackam, A. and Hayden, M.R. and Li, Y. and Cooper, J.K. and Ross, C.A. and Govoni, S. and Vincenz, C. and Cattaneo, E.
DOI: 10.1523/jneurosci.20-10-03705.2000
2000

The modulation of HIP1 function through its interaction with its family member HIP12: implications for the pathogenesis of Huntington disease
American Journal of Human Genetics
Chopra, V. and Metzler, M. and Rasper, D. and Singaraja, R. and Gan, L. and Nicholson, D. and Hayden, M.
2000

Mutations in ABC1 in Tangier disease and familiar high-density lipoprotein deficiency
M S-Medecine Sciences
Marcil, M. and Brooks-Wilson, A. and Kastelein, J. and Hayden, M. and Genest, J.
2000

Huntingtin interacting protein 1 knockout mice are viable and provide insights into the developmental expression of HIP1
Molecular Biology of the Cell
Metzler, MM and Gan, L and Oh, R and Gertsenstein, M and Borowski, A and Jirik, FR and Nagy, A and Hayden, MR
2000

Huntingtin interacting protein 1 knock-out mice are viable and provide insights into the developmental expression of HIP1.
American Journal of Human Genetics
Metzler, MM and Gan, L and Oh, R and Gertsenstein, M and Hackam, AS and Borowski, A and Jirik, FR and Nagy, A and Hayden, MR
2000

Phenotypic correction of feline lipoprotein lipase deficiency by adenoviral gene transfer
Human Gene Therapy
Liu, G. and Ashbourne Excoffon, K.J.D. and Wilson, J.E. and McManus, B.M. and Rogers, Q.R. and Miao, L. and Kastelein, J.J.P. and Lewis, M.E.S. and Hayden, M.R.
DOI: 10.1089/10430340050016120
2000

Massive cholesterol ester accumulation in hepatocytes and intestinal epithelial cells caused by ABC1 mutation in WHAM chickens
Circulation
Attie, AD and Brooks-Wilson, A and Gray-Keller, ME and Zhang, LH and Tebon, A and Mulligan, J and Bitgood, JJ and Cook, ME and Kastelein, JJP and Hayden, MR
2000

Human huntingtin-associated protein (HAP-1) gene: Genomic organisation and an intragenic polymorphism
Gene
Nasir, J. and Lafuente, M.-J. and Duan, K. and Colomer, V. and Engelender, S. and Ingersoll, R. and Margolis, R.L. and Ross, C.A. and Hayden, M.R.
DOI: 10.1016/S0378-1119(00)00269-9
2000

A one-hit model of cell death in inherited neuronal degenerations
Nature
Clarke, G. and Collins, R.A. and Leavitt, B.R. and Andrews, D.F. and Hayden, M.R. and Lumsden, C.J. and McInnes, R.R.
DOI: 10.1038/35018098
2000

Huntington disease: New insights on the role of huntingtin cleavage
Journal of Neural Transmission, Supplement
DOI: 10.1007/978-3-7091-6284-2_1
2000

Familial aggregation of psychotic symptoms in Huntington's disease
American Journal of Psychiatry
Tsuang, D. and Almqvist, E.W. and Lipe, H. and Strgar, F. and DiGiacomo, L. and Hoff, D. and Eugenio, C. and Hayden, M.R. and Bird, T.D.
DOI: 10.1176/appi.ajp.157.12.1955
2000

Defects in cellular cholesterol efflux are frequent cause of HDL deficiency
Circulation
Bissonnette, R and Marcil, M and Molhuizen, HO and Brooks-Wilson, A and Collins, J and Boucher, B and Groen, BK and Roomp, K and Wijland, MJA and Hayden, MR and Kastelein, J and Genest, J
2000

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
Journal of Clinical Investigation
Clee, S.M. and Kastelein, J.J.P. and Van Dam, M. and Marcil, M. and Roomp, K. and Zwarts, K.Y. and Collins, J.A. and Roelants, R. and Tamasawa, N. and Stulc, T. and Suda, T. and Ceska, R. and Boucher, B. and Rondeau, C. and DeSouich, C. and Brooks-Wilson, A. and Molhuizen, H.O.F. and Frohlich, J. and Genest Jr., J. and Hayden, M.R.
DOI: 10.1172/JCI10727
2000

Accelerating the natural history of neurodegeneration in Huntington disease YAC transgenic mice: Facilitation of in vivo screening of potential therapeutic agents.
American Journal of Human Genetics
Leavitt, BR and Gutekunst, CA and Oh, R and Chan, E and Bissada, N and Hersch, S and Hayden, MR
2000

The age modulated phenotype in heterozygotes for mutations in ABC1 includes significantly decreased HDL, increased triglycerides and an increased frequency of coronary artery disease (CAD).
Circulation
Clee, SM and Zwarts, KY and Roomp, K and Collins, JA and Van Dam, M and Marcil, M and Brooks-Wilson, A and Genest, J and Kastelein, JJP and Hayden, MR
2000

Michael smith (1932-2000)
Nature
Hayden, M.R. and Ling, V.
DOI: 10.1038/35048663
2000

Huntingtin is required for normal hematopoiesis
Human Molecular Genetics
Metzler, M. and Helgason, C.D. and Dragatsis, I. and Zhang, T. and Gan, L. and Pineault, N. and Zeitlin, S.O. and Humphries, R.K. and Hayden, M.R.
DOI: 10.1093/hmg/9.3.387
2000

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
Journal of Biological Chemistry
Wellington, C.L. and Singaraja, R. and Ellerby, L. and Savill, J. and Roy, S. and Leavitt, B. and Cattaneo, E. and Hackam, A. and Sharp, A. and Thornberry, N. and Nicholson, D.W. and Bredesen, D.E. and Hayden, M.R.
DOI: 10.1074/jbc.M001475200
2000

CSNPs within the ABC1 gene influence HDL cholesterol levels and risk of coronary artery disease (CAD)
Circulation
Clee, SM and Molhuizen, HO and Zwinderman, AH and Engert, JC and Roomp, K and Zwarts, KY and Jukema, JW and Hudson, TJ and Brooks-Wilson, A and Kastelein, JJP and Hayden, MR
2000

Cholesterol efflux regulatory protein, Tangier disease and familial high density lipoprotein deficiency
Current Opinion in Lipidology
Hayden, M.R. and Clee, S.M. and Brooks-Wilson, A. and Genest Jr., J. and Attie, A. and Kastelein, J.J.P.
DOI: 10.1097/00041433-200004000-00003
2000

Predictive testing for Huntington's disease: The calm after the storm
Lancet
Hayden, M.R.
DOI: 10.1016/S0140-6736(00)03301-8
2000

Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis
Journal of Lipid Research
Clee, S.M. and Bissada, N. and Miao, F. and Miao, L. and Marais, A.D. and Henderson, H.E. and Steures, P. and McManus, J. and McManus, B. and LeBoeuf, R.C. and Kastelein, J.J.P. and Hayden, M.R.
2000

Identification of 20 full-length transcripts in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: Candidate genes for ALS2.
American Journal of Human Genetics
Hadano, S and Yanagisawa, Y and Skaug, J and Fichter, K and Scherer, SW and Rouleau, GA and Hayden, MR and Ikeda, JE
2000

HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin
Mammalian Genome
Chopra, V.S. and Metzler, M. and Rasper, D.M. and Engqvist-Goldstein, A.E.Y. and Singaraja, R. and Gan, L. and Fichter, K.M. and McCutcheon, K. and Drubin, D. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1007/s003350010195
2000

HDL levels in ABCA1 heterozygotes are predicted by cholesterol efflux levels and are influenced by age.
American Journal of Human Genetics
Clee, SM and Zwarts, KY and Roomp, K and Collins, JA and Marcil, M and van Dam, M and Brooks-Wilson, A and Genest, J and Kastelein, JJP and Hayden, MR
2000

Recent insights into the molecular pathogenesis of Huntington disease (vol 19, pg 385, 1999)
Seminars in Neurology
Leavitt, BR and Wellington, CL and Hayden, MR
2000

Lipoprotein lipase activity is associated with severity of angina pectoris
Circulation
Kastelein, J.J.P. and Jukema, J.W. and Zwinderman, A.H. and Clee, S. and Van Boven, A.J. and Jansen, H. and Rabelink, T.J. and Peters, R.J.G. and Lie, K.I. and Liu, G. and Bruschke, A.V.G. and Hayden, M.R.
DOI: 10.1161/01.CIR.102.14.1629
2000

From molecular accomplices to pathways in the pathogenesis of HD: The roles of novel DED containing interacting proteins, HIP1 and Hippi
American Journal of Human Genetics
Singaraja, R. and Gervais, F. and Hackam, A. and Xanthoudakis, S. and Houtzager, V. and Rasper, D. and Roy, S. and Leavitt, B. and Gutekunst, C. A. and Hayden, M. and Nicholson, D.
2000

A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease
American Journal of Human Genetics
Almqvist, E.W. and Bloch, M. and Brinkman, R. and Craufurd, D. and Hayden, M.R.
DOI: 10.1086/302374
1999

Neuronal degeneration in the basal ganglia and loss of pallido- subthalamic synapses in mice with targeted disruption of the Huntington's disease gene
Brain Research
O'Kusky, J.R. and Nasir, J. and Cicchetti, F. and Parent, A. and Hayden, M.R.
DOI: 10.1016/S0006-8993(98)01312-2
1999

Influence of lamotrigine on progression of early Huntington disease: A randomized clinical trial
Neurology
Kremer, B. and Clark, C.M. and Almqvist, E.W. and Raymond, L.A. and Graf, P. and Jacova, C. and Mezei, M. and Hardy, M.A. and Snow, B. and Martin, W. and Hayden, M.R.
1999

Effect of concurrent LDL receptor gene and LPL gene mutations on LDL particles size, density and lipid composition
Atherosclerosis
Zambon, A and Gagne, C and Lupien, PJ and Moorjani, S and Hayden, MR and Brunzell, JD
DOI: 10.1016/S0021-9150(99)80666-2
1999

A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: The Framingham Offspring Study
Clinical Genetics
Gagné, S.E. and Larson, M.G. and Pimstone, S.N. and Schaefer, E.J. and Kastelein, J.J.P. and Wilson, P.W.F. and Ordovas, J.M. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.1999.550609.x
1999

The actin cytoskeleton and endocytosis linked by the Huntingtin Interacting Protein 1 Related (Hip1R), a protein belonging to the Sla2/Hip1 family.
Molecular Biology of the Cell
Engqvist-Goldstein, AEY and Kessels, MM and Chopra, VS and Hayden, MR and Drubin, DG
1999

Lipid and lipoprotein analysis of cats with lipoprotein lipase deficiency
European Journal of Clinical Investigation
Ginzinger, D.G. and Clee, S.M. and Dallongeville, J. and Lewis, M.E.S. and Henderson, H.E. and Bauje, E. and Rogers, Q.R. and Jensen, D.R. and Eckel, R.H. and Dyer, R. and Innis, S. and Jones, B. and Fruchart, J.-C. and Hayden, M.R.
DOI: 10.1046/j.1365-2362.1999.00435.x
1999

Inhibition of caspase cleavage of huntingtin protects neurons from toxicity and aggregate formation.
American Journal of Human Genetics
Wellington, CL and Singaraja, R and Ellerby, L and Savill, J and Roy, S and Leavitt, B and Cattaneo, E and Hackam, A and Sharp, A and Thornberry, N and Bredesen, D and Nicholson, D and Hayden, MR
1999

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Nature Genetics
Brooks-Wilson, A. and Marcil, M. and Clee, S.M. and Zhang, L.-H. and Roomp, K. and Van Dam, M. and Yu, L. and Brewer, C. and Collins, J.A. and Molhuizen, H.O.F. and Loubser, O. and Ouelette, B.F.F. and Fichter, K. and Ashbourne-Excoffon, K.J.D. and Sensen, C.W. and Scherer, S. and Mott, S. and Denis, M. and Martindale, D. and Frohlich, J. and Morgan, K. and Koop, B. and Pimstone, S. and Kastelein, J.J.P. and Genest Jr., J. and Hayden, M.R.
DOI: 10.1038/11905
1999

Life without Huntington: Normal differentiation into functional neurons
Journal of Neurochemistry
Metzler, M. and Chen, N. and Helgason, C.D. and Graham, R.K. and Nichol, K. and McCutcheon, K. and Nasir, J. and Humphries, R.K. and Raymond, L.A. and Hayden, M.R.
DOI: 10.1046/j.1471-4159.1999.0721009.x
1999

Influence of lamotrigine on progression of early Huntington disease - A randomized clinical trial
Neurology
Kremer, B and Clark, CM and Almqvist, EW and Raymond, LA and Graf, P and Jacova, C and Mezei, M and Hardy, MA and Snow, B and Martin, W and Hayden, MR
1999

Genomic organization of the human caspase-9 gene on Chromosome 1p36.1- p36.3
Mammalian Genome
Hadano, S. and Nasir, J. and Nichol, K. and Rasper, D.M. and Vaillancourt, J.P. and Sherer, S.W. and Beatty, B.G. and Ikeda, J.-E. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1007/s003359901086
1999

A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia
Arteriosclerosis, Thrombosis, and Vascular Biology
Wittekoek, M.E. and Moll, E. and Pimstone, S.N. and Trip, M.D. and Lansberg, P.J. and Defesche, J.C. and Van Doormaal, J.J. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1161/01.ATV.19.11.2708
1999

Huntingtin interacting protein-1 (HIP-1) associated neuronal death is accompanied by activation of the caspase and JNK pathways.
American Journal of Human Genetics
Hackam, AS and Yassa, AS and Vaillancourt, J and Metzler, M and Gan, L and Nicholson, DW and Hayden, MR
1999

Allelic but not genetic heterogeneity underlies Tangier disease
Circulation
Brooks-Wilson, AR and Genest, JJ and van Dam, MJ and Marcil, M and Brewer, C and Mott, S and Morgan, K and Hayden, MR and Kastelein, JJP
1999

Recent insights into the molecular pathogenesis of Huntington disease
Seminars in Neurology
Leavitt, B.R. and Wellington, C.L. and Hayden, M.R.
DOI: 10.1055/s-2008-1040853
1999

Phenotypic correction of feline lipoprotein lipase (LPL) deficiency by adenoviral gene transfer.
American Journal of Human Genetics
Liu, G and Exocoffon, KJDA and Wilson, JE and McManus, BM and Miao, L and Lewis, MES and Hayden, MR
1999

Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux
Lancet
Marcil, M. and Brooks-Wilson, A. and Clee, S.M. and Roomp, K. and Zhang, L.-H. and Yu, L. and Collins, J.A. and Van Dam, M. and Molhuizen, H.O.F. and Loubster, O. and Ouellette, B.F.F. and Sensen, C.W. and Fichter, K. and Mott, S. and Denis, M. and Boucher, B. and Pimstone, S. and Genest Jr., J. and Kastelein, J.J.P. and Hayden, M.R.
DOI: 10.1016/S0140-6736(99)07026-9
1999

Endogenous huntingtin modulates the cellular toxicity of mutant huntingtin.
American Journal of Human Genetics
Leavitt, BR and Hackam, A and Gutekunst, CA and McCutcheon, K and Yassa, A and Singaraja, R and Kimel, G and Hersch, S and Vogl, W and Hayden, MR
1999

A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34
Genomics
Hadano, S. and Nichol, K. and Brinkman, R.R. and Nasir, J. and Martindale, D. and Koop, B.F. and Nicholson, D.W. and Scherer, S.W. and Ikeda, J.-E. and Hayden, M.R.
DOI: 10.1006/geno.1998.5637
1999

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin
Journal of Neurochemistry
Chen, N. and Luo, T. and Wellington, C. and Metzler, M. and McCutcheon, K. and Hayden, M.R. and Raymond, L.A.
DOI: 10.1046/j.1471-4159.1999.0721890.x
1999

Mutations in transportin (ABC1) in Tangier disease and familial HDL deficiency.
American Journal of Human Genetics
Brooks-Wilson, AR and Marcil, M and Clee, SM and Zhang, LH and Roomp, K and van Dam, MJ and Yu, L and Brewer, C and Collins, JA and Molhuizen, HOF and Ouellette, BFF and Sensen, CW and Martindale, D and Frohlich, J and Morgan, K and Koop, B and Pimstone, S and Kastelein, JJP and Genest, J and Hayden, MR
1999

Kennedy's disease: Caspase cleavage of the androgen receptor is a crucial event in cytotoxicity
Journal of Neurochemistry
Ellerby, L.M. and Hackam, A.S. and Propp, S.S. and Ellerby, H.M. and Rabizadeh, S. and Cashman, N.R. and Trifiro, M.A. and Pinsky, L. and Wellington, C.L. and Salvesen, G.S. and Hayden, M.R. and Bredesen, D.E.
DOI: 10.1046/j.1471-4159.1999.0720185.x
1999

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease
Human Molecular Genetics
Hackam, A.S. and Singaraja, R. and Zhang, T. and Gan, L. and Hayden, M.R.
DOI: 10.1093/hmg/8.1.25
1999

Effects of wild-type or mutant Huntingtin in striatal cells.
American Journal of Human Genetics
Bauer, JH and Rigamonti, D and De-Fraja, C and Conti, L and Sipione, S and Sciorati, C and Clementi, E and Hackam, A and Hayden, MR and Li, Y and Cooper, JK and Ross, CA and Vincenz, C and Cattaneo, E
1999

An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles
Journal of Cell Biology
Engqvist-Goldstein, ?.E.Y. and Kessels, M.M. and Chopra, V.S. and Hayden, M.R. and Drubin, D.G.
DOI: 10.1083/jcb.147.7.1503
1999

Two common mutations (D9N, N291S) in lipoprotein lipase: A cumulative analysis of their influence on plasma lipids and lipoproteins in men and women
Clinical Genetics
Kastelein, J.J.P. and Ordovas, J.M. and Wittekoek, M.E. and Pimstone, S.N. and Wilson, P.W.F. and Gagné, S.E. and Larson, M.G. and Schaefer, E.J. and Boer, J.M.A. and Gerdes, C. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.1999.560407.x
1999

The lipoprotein lipase S447X variant is associated with decreased systolic and diastolic blood pressure
Circulation
Clee, SM and Loubser, O and Collins, J and Kastelein, JJ and Hayden, MR
1999

Genomic organization of the human caspase-9 gene on Chromosome 1p36.1-p36.3
Mammalian Genome
Hadano, S and Nasir, J and Nichol, K and Rasper, DM and Vaillancourt, JP and Sherer, SW and Beatty, BG and Ikeda, JE and Nicholson, DW and Hayden, MR
1999

Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin
Neuroscience
Kim, M. and Velier, J. and Chase, K. and Laforet, G. and Kalchman, M.A. and Hayden, M.R. and Won, L. and Heller, A. and Aronin, N. and Difiglia, M.
DOI: 10.1016/S0306-4522(98)00400-X
1999

Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin
Philosophical Transactions of the Royal Society B: Biological Sciences
Hackam, A.S. and Hodgson, J.G. and Singaraja, R. and Zhang, T. and Gan, L. and Gutekunst, C.-A. and Hersch, S.M. and Hayden, M.R.
DOI: 10.1098/rstb.1999.0457
1999

Disturbed interaction between Huntingtin and HIP3 implicates defects in neuronal endocytosis in the pathogenesis of HD.
American Journal of Human Genetics
Singaraja, RR and Hadano, S and Metzier, M and Wellington, C and Leavitt, B and Baich, W and Bannykh, S and Fichter, K and Hackam, A and Gan, L and Zhang, T and Yassa, A and McCutcheon, K and Michel, JML and Chopra, V and Sherer, S and Geitz, D and Hayden, MR
1999

Chromosomal localization of the Huntingtin Associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping
Mammalian Genome
Nasir, J. and Maclean, A. and Engelender, S. and Duan, K. and Margolis, R.L. and Kleiderlein, J.J. and Ross, C.A. and Hayden, M.R.
DOI: 10.1007/s003359901009
1999

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
Neuron
Hodgson, J.G. and Agopyan, N. and Gutekunst, C.-A. and Leavitt, B.R. and Lepiane, F. and Singaraja, R. and Smith, D.J. and Bissada, N. and McCutcheon, K. and Nasir, J. and Jamot, L. and Xiao-Jiang, L. and Stevens, M.E. and Rosemond, E. and Roder, J.C. and Phillips, A.G. and Rubin, E.M. and Hersch, S.M. and Hayden, M.R.
DOI: 10.1016/S0896-6273(00)80764-3
1999

A transcript map of the ALS2 candidate locus on human chromosome 2q33-q34, and exclusion of usurpin, caspase-10, and caspase-8 as candidate genes for ALS2.ALS2.
American Journal of Human Genetics
Hadano, S and Nichol, N and Fichter, K and Huizenga, J and Skaug, J and Nasir, J and Martindale, D and Koop, BF and Nicholson, DW and Scherer, SW and Rouleau, GA and Ikeda, JE and Hayden, MR
1999

Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins
Journal of Lipid Research
Henderson, H.E. and Kastelein, J.J.P. and Zwinderman, A.H. and Gagné, E. and Jukema, J.W. and Reymer, P.W.A. and Groenemeyer, B.E. and Lie, K.I. and Bruschke, A.V.G. and Hayden, M.R. and Jansen, H.
1999

Hereditary syringomyelia: A manifestation of familial vascular malformations?
Neurology
Spacey, SD and Ramsay, DA and Hayden, MR
1999

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity
Journal of Biological Chemistry
Ellerby, L.M. and Andrusiak, R.L. and Wellington, C.L. and Hackam, A.S. and Propp, S.S. and Wood, J.D. and Sharp, A.H. and Margolis, R.L. and Ross, C.A. and Salvesen, G.S. and Hayden, M.R. and Bredesen, D.E.
DOI: 10.1074/jbc.274.13.8730
1999

Accurate determination of the number of CAG repeats in the Huntington disease gene using a sequence-specific internal DNA standard
Clinical Genetics
Bruland, O. and Almqvist, E.W. and Goldberg, Y.P. and Boman, H. and Hayden, M.R. and Knappskog, P.M.
DOI: 10.1034/j.1399-0004.1999.550308.x
1999

Ile²²⁵Thr loop mutation in the Lipoprotein Lipase (LPL) gene is a de novo event
American Journal of Medical Genetics
Henderson, H.E. and Bijvoet, S.M. and Mannens, M.A.M.M. and Bruin, T. and Erkelens, D.W. and Hayden, M.R. and Kastelein, J.J.P.
1998

Phenotypic variation in heterozygous familial hypercholesterolemia: A comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada
Arteriosclerosis, Thrombosis, and Vascular Biology
Pimstone, S.N. and Sun, X.-M. and Du Souich, C. and Frohlich, J.J. and Hayden, M.R. and Soutar, A.K.
DOI: 10.1161/01.ATV.18.2.309
1998

In vitro and in vivo models for Huntington disease: Lessons for the polyglutamine expansion disorders,Modeles in vitro et in vivo de la maladie de Huntington: Enseignements pour les pathologies liees a des expansions de polyglutamine
Pathologie Biologie
1998

Compound heterozygosity for frameshift mutations in the gene for lipoprotein lipase in a patient with early onset chylomicronemia
Human Mutation
Foubert, L. and Gennes, J.L.D. and Benlian, P. and Truffert, J. and Miao, L. and Hayden, M.R.
DOI: 10.1002/humu.1380110148
1998

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
Cell Death and Differentiation
Rasper, D.M. and Vaillancourt, J.P. and Hadano, S. and Houtzager, V.M. and Seiden, I. and Keen, S.L.C. and Tawa, P. and Xanthoudakis, S. and Nasir, J. and Martindale, D. and Koop, B.F. and Peterson, E.P. and Thornberry, N.A. and Huang, J. and MacPherson, D.P. and Black, S.C. and Hornung, F. and Lenardo, M.J. and Hayden, M.R. and Roy, S. and Nicholson, D.W.
DOI: 10.1038/sj.cdd.4400370
1998

A novel Glu421Lys substitution in the lipoprotein lipase gene in pregnancy-induced hypertriglyceridemic pancreatitis
Clinica Chimica Acta
Henderson, H. and Leisegang, F. and Hassan, F. and Hayden, M. and Marais, D.
DOI: 10.1016/S0009-8981(97)00144-7
1998

Common variants of lipoprotein lipase (LPL) strongly influence levels of lipids and lipoproteins and coronary artery disease (CAD) in patients with familial hypercholesterolemia (FH)
Circulation
Kastelein, JJP and Wittekoek, ME and Loubser, O and Clee, SM and Collins, J and Moll, E and Pimstone, SN and Hayden, MR
1998

The new clinical genetics: Towards the millennium
Clinical Genetics
Hayden, M.R.
DOI: 10.1034/j.1399-0004.1998.531530101.x
1998

Lipoprotein lipase (LPL) activity is decreased in CAD patients and inversely correlated with severity of angina pectoris and silent myocardial ischemia
Circulation
Kastelein, JJP and Jukema, JW and van Boven, AJ and Jansen, H and Zwinderman, AH and Rabelink, TJ and Peters, RJG and Lie, KI and Bruschke, AVG and Hayden, MR
1998

A mouse protein related to yeast Sla2/end4 and human huntingtin-interacting protein may link the actin cytoskeleton to membrane dynamics
Molecular Biology of the Cell
Engqvist-Goldstein, A and Lila, T and Kalchman, MA and Chopra, V and Hayden, MR and Drubin, DG
1998

The fatal attraction of polyglutamine-containing proteins
Clinical Genetics
Hackam, A.S. and Wellington, C.L. and Hayden, M.R.
DOI: 10.1111/j.1399-0004.1998.tb02687.x
1998

Gene structure and map location of the murine homolog of the Huntington- associated protein, Hap1
Mammalian Genome
Nasir, J. and Duan, K. and Nichol, K. and Engelender, S. and Ashworth, R. and Colomer, V. and Thomas, S. and Disteche, C.M. and Hayden, M.R. and Ross, C.A.
DOI: 10.1007/s003359900819
1998

Dyslipidemias associated with heterozygous lipoprotein lipase mutations in the French-Canadian population
Human Mutation
Julien, P. and Gagné, C. and Murthy, M.R.V. and Lévesque, G. and Moorjani, S. and Cadelis, F. and Hayden, M.R. and Lupien, P.J.
DOI: 10.1002/humu.1380110150
1998

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
Journal of Biological Chemistry
Wellington, C.L. and Ellerby, L.M. and Hackam, A.S. and Margolis, R.L. and Trifiro, M.A. and Singaraja, R. and McCutcheon, K. and Salvesen, G.S. and Propp, S.S. and Bromm, M. and Rowland, K.J. and Zhang, T. and Rasper, D. and Roy, S. and Thornberry, N. and Pinsky, L. and Kakizuka, A. and Ross, C.A. and Nicholson, D.W. and Bredesen, D.E. and Hayden, M.R.
DOI: 10.1074/jbc.273.15.9158
1998

The influence of huntingtin protein size on nuclear localization and cellular toxicity
Journal of Cell Biology
Hackam, A.S. and Singaraja, R. and Wellington, C.L. and Metzler, M. and McCutcheon, K. and Zhang, T. and Kalchman, M. and Hayden, M.R.
DOI: 10.1083/jcb.141.5.1097
1998

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates
Nature Genetics
Martindale, D. and Hackam, A. and Wieczorek, A. and Ellerby, L. and Wellington, C. and McCutcheon, K. and Singaraja, R. and Kazemi-Esfarjani, P. and Devon, R. and Kim, S.U. and Bredesen, D.E. and Tufaro, F. and Hayden, M.R.
DOI: 10.1038/ng0298-150
1998

Ile(225)Thr loop mutation in the lipoprotein lipase (LPL) gene is a de novo event
American Journal of Medical Genetics
Henderson, HE and Bijvoet, SM and Mannens, MAMM and Bruin, T and Erkelens, DW and Hayden, MR and Kastelein, JJP
DOI: 10.1002/(SICI)1096-8628(19980724)78:43.0.CO;2-M
1998

Compound heterozygosity for frameshift mutations in the gene for lipoprotein lipase in a patient with early-onset chylomicronemia
Human Mutation
Foubert, L and De Gennes, JL and Benlian, P and Truffert, J and Miao, L and Hayden, MR
1998

Atherogenicity of lipoprotein lipase is related to its site of expression: In vivo evidence of vessel wall versus plasma effects
Circulation
Clee, SM and Bissada, N and Miao, F and Miao, L and Steures, P and Marais, D and McManus, J and McManus, B and Henderson, HE and Hayden, MR
1998

A Huntington disease-like neurodegenerative disorder maps to chromosome 20p
American Journal of Human Genetics
Xiang, F. and Almqvist, E.W. and Huq, M. and Lundin, A. and Hayden, M.R. and Edström, L. and Anvret, M. and Zhang, Z.
DOI: 10.1086/302093
1998

The Asn9 variant of lipoprotein lipase is associated with the - 93G promoter mutation and an increased risk of coronary artery disease
Clinical Genetics
Kastelein, J.J.P. and Groenemeyer, B.E. and Hallman, D.M. and Henderson, H. and Reymer, P. and Gagné, S.E. and Jansen, H. and Seidell, J.C. and Kromhout, D. and Jukema, J.W. and Bruschke, A.V.G. and Boerwinkle, E. and Hayden, M.R.
DOI: 10.1034/j.1399-0004.1998.531530106.x
1998

Enhanced lipolysis in normal mice expressing liver-derived human lipoprotein lipase after adenoviral gene transfer
Clinical and Investigative Medicine
Liu, G. and Ashbourne Excoffon, K.J.D. and Wilson, J.E. and McManus, B.M. and Miao, L. and Benoit, P. and Duverger, N. and Branellec, D. and Denefle, P. and Hayden, M.R. and Lewis, M.E.S.
1998

A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia
Circulation
Wittekoek, M.E. and Pimstone, S.N. and Reymer, P.W.A. and Feuth, L. and Botma, G.-J. and Defesche, J.C. and Prins, M. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1161/01.CIR.97.8.729
1998

Phenotypic variation in heterozygous familial hypercholesterolemia - A comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada
Arteriosclerosis Thrombosis and Vascular Biology
Pimstone, SN and Sun, XM and du Souich, C and Frohlich, JJ and Hayden, MR and Soutar, AK
1998

In vitro and in vivo models for Huntington disease: lessons for the polyglutamine expansion disorders.
Pathologie Biologie
Hayden, MR
1998

Contribution of DNA sequence and CAG size to mutation frequencies of intermediate alleles for Huntington disease: Evidence from single sperm analyses
Human Molecular Genetics
Chong, S.S. and Almqvist, E. and Telenius, H. and LaTray, L. and Nichol, K. and Bourdelat-Parks, B. and Goldberg, Y.P. and Haddad, B.R. and Richards, F. and Sillence, D. and Greenberg, C.R. and Ives, E. and Van Den Engh, G. and Hughes, M.R. and Hayden, M.R.
DOI: 10.1093/hmg/6.2.301
1997

Toward understanding the molecular pathology of huntington's disease
Brain Pathology
DOI: 10.1111/j.1750-3639.1997.tb00897.x
1997

The likelihood of being affected with huntington disease by a particular age, for a specific CAG size
American Journal of Human Genetics
Brinkman, R.R. and Mezei, M.M. and Theilmann, J. and Almqvist, E. and Hayden, M.R.
1997

Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: Modulation by cholesteryl ester transfer protein and dietary status
Journal of Lipid Research
Clee, S.M. and Zhang, H. and Bissada, N. and Miao, L. and Ehrenborg, E. and Benlian, P. and Shen, G.X. and Angel, A. and LeBoeuf, R.C. and Hayden, M.R.
1997

Premature atherosclerosis in familial chylomicronemia - Reply
New England Journal of Medicine
Benlian, P and Hayden, MR
1997

Development of an in vitro model for Huntington's disease: Evidence that the N-terminal domain of huntingtin is toxic to cells.
American Journal of Human Genetics
Hackam, AS and Ellerby, LM and Wellington, CL and Bredesen, DE and Hayden, MR
1997

Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase - Deficient mice by adenovirus-mediated expression of human lipoprotein lipase
Arteriosclerosis, Thrombosis, and Vascular Biology
Ashbourne Excoffon, K.J.D. and Liu, G. and Miao, L. and Wilson, J.E. and McManus, B.M. and Semenkovich, C.F. and Coleman, T. and Benoit, P. and Duverger, N. and Branellec, D. and Denefle, P. and Hayden, M.R. and Lewis, M.E.S.
DOI: 10.1161/01.atv.17.11.2532
1997

Localization of the cell death genes CPP32 and Mch-2 to human Chromosome 4q
Mammalian Genome
Nasir, J. and Theilmann, J.L. and Chopra, V. and Jones, A.M. and Walker, D. and Rasper, D.M. and Vaillancourt, J.P. and Hewitt, J.E. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1007/s003359900349
1997

Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells
Human Gene Therapy
Liu, G. and Ashbourne Excoffon, K.J.D. and Benoit, P. and Ginzinger, D.G. and Miao, L. and Ehrenborg, E. and Duverger, N. and Denefle, P.P. and Hayden, M.R. and Lewis, M.E.S.
DOI: 10.1089/hum.1997.8.2-205
1997

Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer
American Journal of Human Genetics
Goellner, G.M. and Tester, D. and Thibodeau, S. and Almqvist, E. and Goldberg, Y.P. and Hayden, M.R. and McMurray, C.T.
1997

Ethnic variation and in vivo effects of the -93t¿g promoter variant in the lipoprotein lipase gene
Arteriosclerosis, Thrombosis, and Vascular Biology
Ehrenborg, E. and Clee, S.M. and Pimstone, S.N. and Reymer, P.W.A. and Benlian, P. and Hoogendijk, C.F. and Davis, H.J. and Bissada, N. and Miao, L. and Gagné, S.E. and Greenberg, L.J. and Henry, R. and Henderson, H. and Ordovas, J.M. and Schaefer, E.J. and Kastelein, J.J.P. and Kotze, M.J. and Hayden, M.R.
DOI: 10.1161/01.ATV.17.11.2672
1997

Differences in the phenotype between children with familial defective apolipoprotein B-100 and familial hypercholesterolemia
Arteriosclerosis, Thrombosis, and Vascular Biology
Pimstone, S.N. and Defesche, J.C. and Clee, S.M. and Bakker, H.D. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1161/01.ATV.17.5.826
1997

Diet-induced atherosclerosis in the domestic cat
Laboratory Investigation
Ginzinger, D.G. and Wilson, J.E. and Redenbach, D. and Lewis, M.E.S. and Clee, S.M. and Ashbourne Excoffon, K.J.D. and Rogers, Q.R. and Hayden, M.R. and McManus, B.M.
1997

Risk reversals in predictive testing for Huntington disease
American Journal of Human Genetics
Almqvist, E. and Adam, S. and Bloch, M. and Fuller, A. and Welch, P. and Eisenberg, D. and Whelan, D. and Macgregor, D. and Meschino, W. and Hayden, M.R.
DOI: 10.1086/514873
1997

Rethinking genotype and phenotype correlations in polyglutamine expansion disorders
Human Molecular Genetics
Andrew, S.E. and Goldberg, Y.P. and Hayden, M.R.
DOI: 10.1093/hmg/6.12.2005
1997

Of molecular interactions, mice and mechanisms: New insights into Huntington's disease
Current Opinion in Neurology
Wellington, C.L. and Hayden, M.R.
DOI: 10.1097/00019052-199708000-00003
1997

Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients - The Ser(447)-Stop substitution in the lipoprotein lipase gene
Circulation
Groenemeijer, BE and Hallman, MD and Reymer, PWA and Gagne, E and Kuivenhoven, JA and Bruin, T and Jansen, H and Lie, KI and Bruschke, AVG and Boerwinkle, E and Hayden, MR and Kastelein, JJP
1997

Different mutation rates of similar sized CAG tracts of affected Huntington disease chromosomes by single sperm analysis
American Journal of Human Genetics
Almqvist, E. and Chong, S. S. and Nichol, K. and Telenius, H. and La Tray, L. and Bourdelat-Parks, B. and Haddad, B. R. and Squitieri, F. and Anvret, M. and Van den Engh, G. and Hayden, M.
1997

Common mutations in the lipoprotein lipase gene influence plasma lipids and prevalence of coronary heart disease
Atherosclerosis
Hayden, MR and Gagne, SE and Larson, MG and Wittekoek, ME and Pimstone, SN and Schaefer, EJ and Defesche, JC and Wilson, PWF and Kastelein, JJP and Ordovas, JM
DOI: 10.1016/S0021-9150(97)88161-0
1997

Caspase cleavage of huntingtin, atrophin-1 and androgen receptor
American Journal of Human Genetics
Wellington, CL and Margolis, RL and Trifiro, MA and Ross, CA and Pinsky, L and Nicholson, DW and Hayden, MR
1997

Pathological association and dissociation of functional systems in multiple sclerosis and Huntington's disease
Journal of Clinical and Experimental Neuropsychology
Clark, C.M. and Jacova, C. and Klonoff, H. and Kremer, B. and Hayden, M. and Paty, D.
DOI: 10.1080/01688639708403837
1997

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane- associated huntingtin in the brain
Nature Genetics
Kalchman, M.A. and Koide, H.B. and McCutcheon, K. and Graham, R.K. and Nichol, K. and Nishiyama, K. and Kazemi-Esfarjani, P. and Lynn, F.C. and Wellington, C. and Metzler, M. and Goldberg, Y.P. and Kanazawa, I. and Gietz, R.D. and Hayden, M.R.
DOI: 10.1038/ng0597-44
1997

Genetic variant showing a positive interaction with ß-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients: The Ser⁴⁴⁷- stop substitution in the lipoprotein lipase gene
Circulation
Groenemeijer, B.E. and Hallman, M.D. and Reymer, P.W.A. and Gagné, E. and Kuivenhoven, J.A. and Bruin, T. and Jansen, H. and Lie, K.I. and Bruschke, A.V.G. and Boerwinkle, E. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1161/01.CIR.95.12.2628
1997

Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: Identification of a unique haplotype of the apolipoprotein B-100 allele
Atherosclerosis
Abdel-Wareth, L.O. and Pimstone, S.N. and Lagarde, J.-P. and Raisonnier, A. and Benlian, P. and Pritchard, H. and Hayden, M.R. and Frohlich, J.J.
DOI: 10.1016/S0021-9150(97)00159-7
1997

Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans
Journal of Biological Chemistry
Nielsen, M.S. and Brejning, J. and García, R. and Zhang, H. and Hayden, M.R. and Vilaró, S. and Gliemann, J.
DOI: 10.1074/jbc.272.9.5821
1997

Ethnic variation and in vivo effects of the -93t->g promoter variant in the lipoprotein lipase gene
Arteriosclerosis Thrombosis and Vascular Biology
Ehrenborg, E and Clee, SM and Pimstone, SN and Reymer, PWA and Benlian, P and Hoogendijk, CF and Davis, HJ and Bissada, N and Miao, L and Gagne, SE and Greenberg, LJ and Henry, R and Henderson, H and Ordovas, JM and Schaefer, EJ and Kastelein, JJP and Kotze, MJ and Hayden, MR
1997

Effects of the Ser447Stop mutation in the lipoprotein lipase gene locus on plasma triglyceride rich lipoprotein remnants
Circulation
Ordovas, JM and Gagne, E and McNamara, JR and Shah, PK and Wilson, PWF and Cupples, AL and Hayden, MR and Schaefer, EJ
1997

Dilemmas of anonymous predictive testing for Huntington disease: Privacy vs. optimal care
American Journal of Medical Genetics
Burgess, M.M. and Adam, S. and Bloch, M. and Hayden, M.R.
DOI: 10.1002/(SICI)1096-8628(19970808)71:23.0.CO;2-9
1997

Assessment of French patients with LPL deficiency for French Canadian mutations
Journal of Medical Genetics
Foubert, L. and De Gennes, J.L. and Lagarde, J.P. and Ehrenborg, E. and Raisonnier, A. and Girardet, J.P. and Hayden, M.R. and Benlian, P.
DOI: 10.1136/jmg.34.8.672
1997

A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in moroccans of Berber ancestry
Human Mutation
Foubert, L. and Bruin, T. and De Gennes, J.L. and Ehrenborg, E. and Furioli, J. and Kastelein, J. and Benlian, P. and Hayden, M.
DOI: 10.1002/(SICI)1098-1004(1997)10:33.0.CO;2-E
1997

Premature atherosclerosis in familial chylomicronemia [5]
New England Journal of Medicine
Pedro-Botet, J. and Rubies-Prat, J. and Benlian, P. and Hayden, M.R.
DOI: 10.1056/NEJM199704033361416
1997

Phenotypic variation in familial hypercholesterolemia: A comparison of Chinese patients heterozygous for the same or similar mutations in the low density lipoprotein-receptor gene living in China or Canada
Atherosclerosis
Sun, XM and Pimstone, SN and deSouich, C and Frohlich, J and Hayden, MR and Soutar, AK
DOI: 10.1016/S0021-9150(97)88444-4
1997

Molecular genetics as tools to redefine the clinics of lipoprotein disorders: The examples of lipoprotein lipase deficiency
Atherosclerosis
Benlian, P. and Hayden, M. and deGennes, J. L.
DOI: 10.1016/s0021-9150(97)88611-x
1997

Interleukin-1ß-converting enzyme (ICE) and related cell death genes ICE(rel)-II and ICE(rel)-III map to the same PAC clone at band 11q22.2-22.3
Mammalian Genome
Nasir, J. and Theilmann, J.L. and Vaillancourt, J.P. and Munday, N.A. and Ali, A. and Scherer, S. and Beatty, B. and Nicholson, D.W. and Hayden, M.R.
DOI: 10.1007/s003359900514
1997

Development of YAC transgenic mice expressing mutant human huntingtin containing different sized polyglutamine tracts.
American Journal of Human Genetics
Hodgson, G and Smith, D and Nichol, K and Bissada, N and McCutcheon, K and LePaine, F and Stevens, M and Okusky, JR and Phillips, T and Rubin, EM and Hayden, MR
1997

Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase
Arteriosclerosis Thrombosis and Vascular Biology
Excoffon, KJDA and Liu, GQ and Miao, L and Wilson, JE and McManus, BM and Semenkovich, CF and Coleman, T and Benoit, P and Duverger, N and Branellec, D and Denefle, P and Hayden, MR and Lewis, MES
1997

Analysis of cholesteryl ester transfer activity in adipose tissue
International Journal of Obesity
1996

Origin and migration of an Afrikaner founder mutation FH(Afrikaner-2) (V408M) causing familial hypercholesterolemia
Gene Geography
Defesche, J.c. and Van Diermen, D.E. and Hayden, M.R. and Kastelein, J.P.P.
1996

MED-PED: An integrated genetic strategy for preventing early deaths
Genetic Approaches To Noncommunicable Diseases
Williams, RR and HamiltonCraig, I and Kostner, GM and Hegele, RA and Hayden, MR and Pimstone, SN and Faergeman, O and Schuster, H and SteinhagenThiessen, E and Beisiegel, U and Keller, C and Czeizel, AE and Leitersdorf, E and Kastelein, JC and Defesche, JJP and Ose, L and Leren, TP and Seftel, HC and Raal, FJ and Marais, AD and Eriksson, M and Keller, U and Miserez, AR and Jeck, T and Betterridge, DJ and Humphries, SE and Day, INM and Kwiterovich, PO and Lees, RS and Stein, E and Illingworth, R and Kane, J and Boulyjenkov, V and Berg, K and Christen, Y
1996

Gene-based therapeutic strategies for human lipoprotein lipase (LPL) deficiency: Rationale and prospects for alteration of atherogenic risk
Transfusion Science
DOI: 10.1016/0955-3886(95)00061-5
1996

A mutation in the lipoprotein lipase gene is the molecular basis of chylomicronemia in a colony of domestic cats
Journal of Clinical Investigation
Ginzinger, D.G. and Lewis, M.E.S. and Ma, Y. and Jones, B.R. and Liu, G. and Jones, S.D. and Hayden, M.R.
DOI: 10.1172/JCI118541
1996

A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron triglyceride and retinyl palmitate response in normolipidemic carriers
Journal of Lipid Research
Pimstone, S.N. and Clee, S.M. and Gagné, S.E. and Miao, L. and Zhang, H. and Stein, E.A. and Hayden, M.R.
1996

Unified Huntington's disease rating scale: Reliability and consistency
Movement Disorders
Kieburtz, K. and Penney, J. B. and Como, P. and Ranen, N. and Shoulson, I. and Feigin, A. and Abwender, D. and Greenamyre, J. T. and Higgins, D. and Marshall, F. J. and Goldstein, J. and Steinberg, K. and Shih, C. and Richard, I. and Hickey, C. and Zimmerman, C. and Orme, C. and Claude, K. and Oakes, D. and Sax, D. S. and Kim, A. and Hersch, S. and Jones, R. and Auchus, A. and Olsen, D. and BisseyBlack, C. and Rubin, A. and Schwartz, R. and Dubinsky, R. and Mallonee, W. and Gray, C. and Godfrey, N. and Suter, G. and Shannon, K. M. and Stebbins, G. T. and Jaglin, J. A. and Marder, K. and Taylor, S. and Louis, E. and Moskowitz, C. and Thorne, D. and Zubin, N. and Wexler, N. and Swenson, M. R. and Paulsen, J. and Swerdlow, N. and Albin, R. and Wernette, C. and Walker, F. and Hunt, V. and Roos, R. A. C. and Young, A. B. and Koroshetz, W. and Bird, E. and Meyers, R. and Cudkowicz, M. and Guttman, M. and StCyr, J. and Burkholder, J. and Lundin, A. and Ashizawa, T. and Jankovic, J. and Siemers, E. and Quaid, K. and Martin, W. and SanchezRamos, J. and Facca, A. and Rey, G. and Suchowersky, O. and Rohs, G. and Klinek, M. L. and Ross, C. and Bylsma, F. W. and Sherr, M. and Hayden, M. and Raymond, L. and Clark, C. and Kremer, B.
1996

Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familiar combined hyperlipoproteinemia in French Canadian subjects
Journal of Lipid Research
Marcil, M. and Boucher, B. and Gagne, E. and Davignon, J. and Hayden, M. and Genest, J.
1996

Effects of lipoprotein lipase gene mutations on plasma lipids: The Framingham Offspring Study.
Circulation
Gagne, SE and Pimstone, SN and Larson, MG and Schaefer, EJ and Wilson, PWF and Ordovas, JM and Hayden, MR
1996

A long term (ca 5 years) prospective assessment of psychological consequences of predictive testing for Huntington disease (HD)
American journal of human genetics
Wiggins, S. and Green, T. and Adam, S. and Hayden, M.R.
1996

Reduced cholesteryl ester transfer in plasma of patients with lipoprotein lipase deficiency
Journal of Lipid Research
Bagdade, J.D. and Ritter, M.C. and Lithell, H. and Bassett, D. and Mailly, F. and Talmud, P. and Hayden, M.R.
1996

Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250 ¿ Asn; Ser251 ¿ Cys) resulting in lipoprotein lipase (LPL) deficiency
Netherlands Journal of Medicine
Bijvoet, S.M. and Wiebusch, H. and Ma, Y. and Reymer, P.W.A. and Bruin, T. and Bakker, H.D. and Funke, H. and Assmann, G. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1016/0300-2977(96)00043-5
1996

Common sequence variants of lipoprotein lipase: Standardized studies of in vitro expression and catalytic function
Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
Zhang, H. and Henderson, H. and Gagne, S.E. and Clee, S.M. and Miao, L. and Liu, G. and Hayden, M.R.
DOI: 10.1016/0005-2760(96)00059-8
1996

Predictive testing for Huntington disease: Lessons for other adult onset disorders
Genetic Approaches To Noncommunicable Diseases
Hayden, MR and Berg, K and Boulyjenkov, V and Christen, Y
1996

Lack of association of the apolipoprotein A-I-C-III-A-IV gene Xmnl and Sstl polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects
Journal of Lipid Research
Marcil, M. and Boucher, B. and Gagné, E. and Davignon, J. and Hayden, M. and Genest Jr., J.
1996

Combined effect of familial hypercholesterolemia and lipoprotein lipase deficiency in determining low density lipoprotein size, buoyancy and lipid composition
Journal of Investigative Medicine
Zambon, A. and Hokanson, J.E. and Gagne, C. and Lupien, P.J. and Moorjani, S. and Hayden, M.R. and Brunzell, J.D.
1996

Treatment of familial hypercholesterolemia in children and adolescents: Effect of lovastatin
Pediatrics
Lambert, M. and Lupien, P.-J. and Gagné, C. and Lévy, E. and Blaichman, S. and Langlois, S. and Hayden, M. and Rose, V. and Clarke, J.T.R. and Wolfe, B.M.J. and Clarson, C. and Parsons, H. and Stephure, D.K. and Potvin, D. and Lambert, J.
1996

The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis
Circulation
Jukema, J.W. and Van Boven, A.J. and Groenemeijer, B. and Zwinderman, A.H. and Reiber, J.H.C. and Bruschke, A.V.G. and Henneman, J.A. and Molhoek, G.P. and Bruin, T. and Jansen, H. and Gagné, E. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1161/01.CIR.94.8.1913
1996

The Asp(9) Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis
Circulation
Jukema, JW and vanBoven, AJ and Groenemeijer, B and Zwinderman, AH and Reiber, JHC and Bruschke, AVG and Henneman, JA and Molhoek, GP and Bruin, T and Jansen, H and Gagne, E and Hayden, MR and Kastelein, JJP
1996

Patients' rights to laboratory data: Trinucleotide repeat length in huntington disease
American Journal of Medical Genetics
Burgess, M.M. and Hayden, M.R.
1996

Lipoprotein lipase increases HDL levels in mice expressing cholesterol ester transfer protein
Circulation
Clee, SM and Zhang, HF and Benlian, P and Miao, L and Bissada, N and Shen, GX and Angel, A and LeBoeuf, FC and Hayden, MR
1996

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme
Journal of Biological Chemistry
Kalchman, MA and Graham, RK and Xia, G and Koide, HB and Hodgson, JG and Graham, KC and Goldberg, YP and Gietz, RD and Pickart, CM and Hayden, MR
1996

Heterozygous mutations in the lipoprotein lipase gene contribute to chylomicronemia in the adult
Journal of Investigative Medicine
Nevin, D.N. and Deeb, S.S. and Hayden, M.R. and Brunzell, J.D.
1996

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript
Human Molecular Genetics
Goldberg, Y.P. and Kalchman, M.A. and Metzler, M. and Nasir, J. and Zeisler, J. and Graham, R. and Koide, H.B. and O'Kusky, J. and Sharp, A.H. and Ross, C.A. and Jirik, F. and Hayden, M.R.
DOI: 10.1093/hmg/5.2.177
1996

Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats
American Journal of Human Genetics
1996

LPL gene mutation, causing only subtle changes in plasma lipids, promotes progression of coronary atherosclerosis which can be reversed by pravastatin
Circulation
Jukema, JW and vanBoven, AJ and Groenemeyer, B and Zwinderman, AH and Reiber, JHC and Bruschke, AVG and Henneman, JA and Molhoek, P and Bruin, T and Gagne, E and Hayden, MR and Kastelein, JJ
1996

Diet-induced atherosclerosis in normal and LPL deficient heterozygote cats
Laboratory Investigation
Ginzinger, D. and Redenbach, D. and Wilson, J. E. and Lewis, S. and Betts, J. and McManus, B. M. and Hayden, M.
1996

Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency
American Journal of Human Genetics
Benlian, P. and Foubert, L. and Gagné, E. and Bernard, L. and De Gennes, J.L. and Langlois, S. and Robinson, W. and Hayden, M.
1996

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
Nature Genetics
Goldberg, Y.P. and Nicholson, D.W. and Rasper, D.M. and Kalchman, M.A. and Koide, H.B. and Graham, R.K. and Bromm, M. and Kazemi-Esfarjani, P. and Thornberry, N.A. and Vaillancourt, J.P. and Hayden, M.R.
DOI: 10.1038/ng0896-442
1996

Adverse psychological events occurring in the first year after predictive testing for Huntington's disease
Journal of Medical Genetics
Lawson, K. and Wiggins, S. and Green, T. and Adam, S. and Bloch, M. and Hayden, M.R. and Klimek, M. and Suchowersky, O. and Grover, S. and Bamforth, S. and Shokeir, M.H.K. and Greenberg, C. and Kane, J. and Soltan, H. and Eisenberg, D. and Whelan, D. and MacGregor, D. and Summers, A. and Meschino, W. and Hunter, A. and MacLeod, P. and Dufrasne, S. and Rosenblatt, D. and Prevost, C. and Fuller, A. and Welch, P. and Ives, E.
1996

A new mutation destroying disulphide bridging in the C-terminal domain of lipoprotein lipase
Biochemical and Biophysical Research Communications
Henderson, H.E. and Hassan, F. and Marais, D. and Hayden, M.R.
DOI: 10.1006/bbrc.1996.1487
1996

Update on genetics of Huntington's disease: availability of direct and accurate predictive test.
Italian journal of neurological sciences
Squitieri, F. and Campanella, G. and Hayden, M.R.
DOI: 10.1007/BF01995681
1996

Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene
New England Journal of Medicine
Benlian, P. and De Gennes, J.L. and Foubert, L. and Zhang, H. and Gagné, S.E. and Hayden, M.
DOI: 10.1056/NEJM199609193351203
1996

Origin and migration of an Afrikaner founder mutation FHAfrikaner-2 (V408M) causing familial hypercholesterolemia
Gene Geography
Defesche, JC and VanDiermen, DE and Hayden, MR and Kastelein, JPP
1996

Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme
Journal of Biological Chemistry
Kalchman, M.A. and Graham, R.K. and Xia, G. and Brook Koide, H. and Graeme Hodgson, J. and Graham, K.C. and Paul Goldberg, Y. and Dan Gietz, R. and Pickart, C.M. and Hayden, M.R.
DOI: 10.1074/jbc.271.32.19385
1996

Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency
Journal of Lipid Research
Bijvoet, S. and Gagné, S.E. and Moorjani, S. and Gagné, C. and Henderson, H.E. and Fruchart, J.-C. and Dallongeville, J. and Alaupovic, P. and Prins, M. and Kastelein, J.J.P. and Hayden, M.R.
1996

A common alteration in the LPL gene resulting in altered lipoprotein levels
Nutrition, Genetics, and Heart Disease
Pimstone, S and Gagne, E and Zhang, H and Reymer, P and Kastelein, JJP and Ma, Y and Hayden, MR and Bray, GA and Ryan, DH
1996

Huntington disease: New insights into the relationship between CAG expansion and disease
Human Molecular Genetics
Nasir, J. and Goldberg, Y.P. and Hayden, M.R.
1996

Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype
Human Molecular Genetics
Hodgson, J.G. and Smith, D.J. and McCutcheon, K. and Koide, H.B. and Nishiyama, K. and Dinulos, M.B. and Stevens, M.E. and Bissada, N. and Nasir, J. and Kanazawa, I. and Disteche, C.M. and Rubin, E.M. and Hayden, M.R.
DOI: 10.1093/hmg/5.12.1875
1996

A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) contributes to the expression of familial combined hyperlipidemia
Human Molecular Genetics
Reymer, P.W.A. and Groenemeyer, B.E. and Gagné, E. and Miao, L. and Appelman, E.E.G. and Seidel, J.C. and Kromhout, D. and Bijvoet, S.M. and Van De Oever, K. and Bruin, T. and Hayden, M.R. and P.kastelein, J.J.
DOI: 10.1093/hmg/4.9.1543
1995

Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human Chromosome 4q21.2 by fluorescence in situ hybridization
Mammalian Genome
Leung, P.C.K. and Squire, J. and Peng, C. and Fan, N. and Hayden, M.R. and Olofsson, J.I.
DOI: 10.1007/BF00352431
1995

Hereditary late-onset chorea without significant dementia: Genetic evidence for substantial phenotypic variation in Huntington's disease
Neurology
1995

TARGETED DISRUPTION OF THE HUNTINGTONS-DISEASE GENE RESULTS IN EMBRYONIC LETHALITY IN HOMOZYGOTES AND BEHAVIORAL AND NEUROPATHOLOGICAL DEFECTS IN HETEROZYGOTES
American Journal of Human Genetics
Nasir, J. and Floresco, S. and Okusky, J. and Diewert, V. and Richman, J. and Zeisler, J. and Borowski, A. and Metzler, M. and Graham, R. and Marth, J. and Phillips, A. and Hayden, M.
1995

SOMATIC MOSAICISM IN SPERM IS ASSOCIATED WITH INTERGENERATIONAL (CAG)N CHANGES IN HUNTINGTON DISEASE (VOL 4, PG 189, 1995)
Human Molecular Genetics
TELENIUS, H and ALMQVIST, E and KREMER, B and SPENCE, N and SQUITIERI, F and NICHOL, K and GRANDELL, U and STARR, E and BENJAMIN, C and CASTALDO, I and CALABRESE, O and ANVRET, M and GOLDBERG, YP and HAYDEN, MR
DOI: 10.1093/hmg/4.5.974-b
1995

POSTPRANDIAL RETINYL PALMITATE RESPONSE SUPPORTS EVIDENCE FOR A FUNCTIONAL EFFECT OF THE ASN291SER MUTATION IN THE LIPOPROTEIN-LIPASE GENE
Circulation
PIMSTONE, SN and GAGNE, E and CLEE, SM and STEIN, EA and HAYDEN, MR
1995

Mutations in the Gene for Lipoprotein Lipase a Cause for Low HDL Cholesterol Levels in Individuals Heterozygous for Familial Hypercholesterolemia
Arteriosclerosis, Thrombosis, and Vascular Biology
Pimstone, S.N. and Gagné, S.E. and Gagné, C. and Lupien, P.J. and Gaudet, D. and Williams, R.R. and Kotze, M. and Reymer, P.W.A. and Defesche, J.C. and Kastelein, J.J.P. and Moorjani, S. and Hayden, M.R.
DOI: 10.1161/01.ATV.15.10.1704
1995

Long-term efficacy and tolerability of simvastatin in a large cohort of elderly hypercholesterolemic patients
Atherosclerosis
Lansberg, P.J. and Mitchel, Y.B. and Shapiro, D. and Kastelein, J.J.P. and Altman, R. and Jerums, G. and Bolzano, K. and Giannini, S. and Davignon, J. and DeWailly, P. and Darioli, R. and Mancini, M. and Scott, R. and Hayden, M.R.
DOI: 10.1016/0021-9150(95)05523-Y
1995

LACK OF ASSOCIATION OF THE APO AI-CIII-AIV GENE XMNL AND SSTL POLYMORPHISMS AND OF LPL GENE-MUTATIONS IN FAMILIAL COMBINED HYPERLIPOPROTEINEMIA IN FRENCH-CANADIAN SUBJECTS
Circulation
Marcil, M. and Boucher, B. and Gagne, E. and Davignon, J. and Hayden, M. and Genest, J.
1995

INCREASED INSTABILITY OF INTERMEDIATE ALLELES IN FAMILIES WITH SPORADIC HUNTINGTON DISEASE COMPARED TO INTERMEDIATE ALLELES IN THE GENERAL-POPULATION - IMPLICATIONS FOR GENETIC-COUNSELING
American Journal of Human Genetics
GOLDBERG, YP and ZIESLER, J and ALMQVIST, E and SILLENCE, D and RICHARDS, F and BUCHANAN, J and TELENIUS, H and HAYDEN, MR
1995

Summary of the 1993 ASHG ancillary meeting 'recent research on chromosome 4p syndromes and genes'
American Journal of Medical Genetics
DOI: 10.1002/ajmg.1320550412
1995

Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in huntington disease
Human Molecular Genetics
Telenius, H. and Almqvist, E. and Kremer, B. and Spence, N. and Squitieri, F. and Nichol, K. and Grandell, U. and Starr, E. and Benjamin, C. and Castaldo, I. and Calabrese, O. and Anvret, M. and Goldberg, Y.P. and Hayden, M.R.
DOI: 10.1093/hmg/4.2.189
1995

MECHANISMS UNDERLYING (CAG) EXPANDION IN HUNTINGTON DISEASE INCLUDE TISSUE-SPECIFIC AND CIS-ACTING FACTORS
Journal of Cellular Biochemistry
TELENIUS, H and ALMQVIST, E and KREMER, B and SPENCE, N and NICHOL, K and SQUITIERI, F and THEILMANN, J and ANVRET, M and GOLDBERG, YP and HAYDEN, MR
1995

Genomic organization of the human a-adducin gene and its alternately spliced isoforms
Genomics
Lin, B. and Nasir, J. and McDonald, H. and Graham, R. and Rommens, J.M. and Goldberg, Y.P. and Hayden, M.R.
DOI: 10.1016/0888-7543(95)80113-Z
1995

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
Cell
Nasir, J. and Floresco, S.B. and O'Kusky, J.R. and Diewert, V.M. and Richman, J.M. and Zeisler, J. and Borowski, A. and Marth, J.D. and Phillips, A.G. and Hayden, M.R.
DOI: 10.1016/0092-8674(95)90542-1
1995

PREDICTIVE TESTING FOR HUNTINGTONS-DISEASE (HD) - DIFFERENCES IN UPTAKE AND CHARACTERISTICS OF LINKED MARKER AND DIRECT TEST COHORTS
American Journal of Human Genetics
Adam, S. and Wiggins, S. and Lawson, K. and McKellin, B. and Hayden, M.
1995

Patients with ApoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291¿Ser mutation in the human LPL gene
Arteriosclerosis, Thrombosis, and Vascular Biology
Zhang, H. and Reymer, P.W.A. and Liu, M.-S. and Forsythe, I.J. and Groenemeyer, B.E. and Frohlich, J. and Brunzell, J.D. and Kastelein, J.J.P. and Hayden, M.R. and Ma, Y.
DOI: 10.1161/01.ATV.15.10.1695
1995

LIPOPROTEIN ANALYSIS IN A COLONY OF LIPOPROTEIN-LIPASE DEFICIENT CATS
Circulation
GINZINGER, DG and DALLONGEVILLE, J and ROGERS, Q and HAYDEN, MR
1995

Erratum: Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in Huntington disease(Human Molecular Genetics(1995)4(189-195))
Human Molecular Genetics
Telenius, H. and Almqvist, E. and Kremer, B. and Spence, N. and Squitieri, F. and Nichol, K. and Grandell, U. and Starr, E. and Benjamin, C. and Castaldo, I. and Calabrese, O. and Anvret, M. and Goldberg, Y.P. and Hayden, M.R.
1995

Ancestral differences in the distribution of the d2642 glutamic acid polymorphism is associated with varying CAG repeat lengths on normal chromosomes: Insights into the genetic evolution of huntington disease
Human Molecular Genetics
Almqvist, E. and Spence, N. and Nichol, K. and Andrew, S.E. and Vesa, J. and Peltonen, L. and Anvret, M. and Goto, J. and Kanazawa, I. and Goldberg, Y.P. and Hayden, M.R.
DOI: 10.1093/hmg/4.2.207
1995

A 2-YEAR PROSPECTIVE ASSESSMENT OF SOCIAL AND PSYCHOLOGICAL CONSEQUENCES OF PREDICTIVE TESTING FOR HUNTINGTONS-DISEASE (HD)
American Journal of Human Genetics
WIGGINS, S and COPLEY, T and ADAM, S and LAWSON, K and HAYDEN, MR
1995

PATIENT RIGHTS TO LABORATORY DATA - TRINEUCLEOTIDE REPEAT LENGTH IN HUNTINGTON DISEASE
American Journal of Human Genetics
Adams, S. and Almqvist, E. and Burgess, M. and Hayden, M.
1995

Origins and evolution of huntington disease chromosomes
Neurodegeneration
Andrew, S.E. and Hayden, M.R.
DOI: 10.1016/1055-8330(95)90013-6
1995

Erratum: Somatic mosaicism in sperm is associated with intergenerational (cag)n changes in huntington disease
Human Molecular Genetics
Telenius, H. and Almqvist, E. and Kremer, B. and Spence, N. and Squitieri, F. and Nichol, K. and Grandell, U. and Starr, E. and Benjamin, C. and Castaldo, I. and Calabrese, O. and Anvret, M. and Goldberg, Y.P. and Hayden, M.R.
DOI: 10.1093/hmg/4.5.974-u
1995

Structural analysis of the 5' region of mouse and human huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms
Genomics
Lin, B. and Nasir, J. and Kalchman, M.A. and McDonald, H. and Zeisler, J. and Goldberg, Y.P. and Hayden, M.R.
DOI: 10.1016/0888-7543(95)80014-D
1995

RETROVIRAL-MEDIATED GENE-TRANSFER AND EXPRESSION OF HUMAN LIPOPROTEIN-LIPASE IN SOMATIC-CELLS
Human Gene Therapy
LEWIS, MES and FORSYTHE, IJ and MARTH, JD and BRUNZELL, JD and HAYDEN, MR and HUMPHRIES, RK
DOI: 10.1089/hum.1995.6.7-853
1995

Retroviral-mediated gene transfer and expression of human lipoprotein lipase in somatic cells
Human Gene Therapy
1995

MUTATIONS IN THE GENE FOR LIPOPROTEIN-LIPASE - A CAUSE FOR LOW HDL CHOLESTEROL LEVELS IN INDIVIDUALS HETEROZYGOUS FOR FAMILIAL HYPERCHOLESTEROLEMIA
Arteriosclerosis Thrombosis and Vascular Biology
PIMSTONE, SN and GAGNE, SE and GAGNE, C and LUPIEN, PJ and GAUDET, D and WILLIAMS, RR and KOTZE, M and REYMER, PWA and DEFESCHE, JC and KASTELEIN, JJP and MOORJANI, S and HAYDEN, MR
1995

Many roads lead to atheroma
Nature Medicine
Hayden, M.R. and Reidy, M.
DOI: 10.1038/nm0195-22
1995

FALSE NEGATIVES AND POSITIVES IN PREDICTIVE TESTING FOR HUNTINGTON DISEASE THE IMPORTANCE OF ACCURATE ASSESSMENT OF THE ADJACENT CCG REPEAT
American Journal of Human Genetics
ALMQVIST, E and GOLDBERG, YP and HAYDEN, MR
1995

YAC TRANSGENIC MICE CONTAINING THE HUNTINGTON DISEASE GENE
American Journal of Human Genetics
HODGSON, G and SMITH, D and TELENIUS, H and NASIR, J and RUBIN, EM and HAYDEN, MR
1995

STRUCTURAL FEATURES IN LIPOPROTEIN-LIPASE NECESSARY FOR THE MEDIATION OF LIPOPROTEIN UPTAKE INTO CELLS
Journal of Lipid Research
KRAPP, A and ZHANG, HF and GINZINGER, D and LIU, MS and LINDBERG, A and OLIVECRONA, G and HAYDEN, MR and BEISIEGEL, U
1995

Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes
American Journal of Human Genetics
Kremer, B. and Almqvist, E. and Theilmann, J. and Spence, N. and Telenius, H. and Goldberg, Y.P. and Hayden, M.R.
1995

Psychological effects of predictive testing for Huntington's disease.
Advances in neurology
Hayden, M.R. and Bloch, M. and Wiggins, S.
1995

HEREDITARY LATE-ONSET CHOREA WITHOUT SIGNIFICANT DEMENTIA - GENETIC-EVIDENCE FOR SUBSTANTIAL PHENOTYPIC VARIATION IN HUNTINGTONS-DISEASE
Neurology
BRITTON, JW and UITTI, RJ and AHLSKOG, JE and ROBINSON, RG and KREMER, B and HAYDEN, MR
1995

COMPLETE PATERNAL ISODISOMY OF CHROMOSOME-8 UNMASKED BY THE MOLECULAR CHARACTERIZATION OF LIPOPROTEIN-LIPASE DEFICIENCY
American Journal of Human Genetics
BENLIAN, P and FOUBERT, L and BERNARD, L and GAGNE, E and FORSYTHE, I and LAGARDE, IP and TELENIUS, H and LANGLOIS, S and DEGENNES, IL and HAYDEN, MR
1995

Are we all of one mind? Clinicians' and patients' opinions regarding the development of a service protocol for predictive testing for Huntington disease
American Journal of Medical Genetics
Copley, T.T. and Wiggins, S. and Dufrasne, S. and Bloch, M. and Adam, S. and McKellin, W. and Hayden, M.R. and Ives, E. and Welch, J.P. and Fuller, A. and Miller, S. and Andermann, E. and Roy, M. and McLeod, P. and Hunter, A. and Meschino, W. and Summers, A. and Whelan, D. and Eisenberg, D.
DOI: 10.1002/ajmg.1320580113
1995

TRANSACTIVATIONAL ANALYSIS OF THE GLUTAMINE-RICH REGIONS OF THE HUMAN ANDROGEN RECEPTOR AND THE HUNTINGTON DISEASE GENE
American Journal of Human Genetics
KAZEMIESFARJANI, P and GOLDBERG, YP and YAO, J and DETOURREIL, AS and TRIFIRO, M and HAYDEN, MR and PINSKY, L
1995

Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells
Journal of Lipid Research
Krapp, A. and Zhang, H. and Ginzinger, D. and Liu, M.-S. and Lindberg, A. and Olivecrona, G. and Hayden, M.R. and Beisiegel, U.
1995

PATIENTS WITH APOE3 DEFICIENCY (E2/2, E3/2, AND E4/2) WHO MANIFEST WITH HYPERLIPIDEMIA HAVE INCREASED FREQUENCY OF AN ASN 291-]SER MUTATION IN THE HUMAN LPL GENE
Arteriosclerosis Thrombosis and Vascular Biology
ZHANG, HF and REYMER, PWA and LIU, MS and FORSYTHE, IJ and GROENEMEYER, BE and FROHLICH, J and BRUNZELL, JD and KASTELEIN, JJP and HAYDEN, MR and MA, YH
1995

Increased instability of intermediate alleles in families with sporadic huntington disease compared to similar sized intermediate alleles in the general population
Human Molecular Genetics
Goldberg, Y.P. and Mcmurray, C.T. and Zeisier, J. and Almqvist, E. and Sillence, D. and Richards, F. and Gacy, A.M. and Buchanan, J. and Telenius, H. and Hayden, M.
DOI: 10.1093/hmg/4.10.1911
1995

A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis
Nature Genetics
Reymer, P.W.A. and Gagné, E. and Groenemeyer, B.E. and Zhang, H. and Forsyth, I. and Jansen, H. and Seidell, J.C. and Kromhout, D. and Lie, K.E. and Kastelein, J. and Hayden, M.R.
DOI: 10.1038/ng0595-28
1995

A compound heterozygote for lipoprotein lipase deficiency, Val⁶⁹¿Leu and Gly¹⁸⁸¿Glu: Correlation between in vitro LPL activity and clinical expression
Journal of Lipid Research
Bruin, T. and Tuzgol, S. and Mulder, W.J. and Van den Ende, A.E. and Jansen, H. and Hayden, M.R. and Kastelein, J.J.P.
1994

Homozygosity for a mutation in the lipoprotein lipase gene (Gly¹³⁹¿Ser) causes chylomicronaemia in a boy of Spanish descent
Human Genetics
Bijvoet, S.M. and Bruin, T. and Thzgöl, S. and Bakker, H.D. and Hayden, M.R. and Kastelein, J.J.P.
DOI: 10.1007/BF00212035
1994

Guidelines for the molecular genetics predictive test in Huntington's disease
Journal of Medical Genetics
Went., L. and Broholm, J. and Cassiman, J.-J. and Craufurd, D. and Falek, A. and Farmer-Little, C. and Hayden, M. and Kapp, R. and Krahnen, K. and Martinez-Descals, A. and Mol, M. and Myrianthopoulos, N. and Petit, H. and Quaid, K. and De Somviele, C. and Taylor, E. and Tyler, A. and Walker, R. and Wexler, N.
1994

Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase
Journal of Biological Chemistry
Liu, M.-S. and Jirik, F.R. and LeBoeuf, R.C. and Henderson, H. and Castellani, L.W. and Lusis, A.J. and Ma, Y. and Forsythe, I.J. and Zhang, H. and Kirk, E. and Brunzell, J.D. and Hayden, M.R.
1994

Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase
Journal of Lipid Research
Ma, Y. and Henderson, H.E. and Liu, M.-S. and Zhang, H. and Forsythe, I.J. and Clarke-Lewis, I. and Hayden, M.R. and Brunzell, J.D.
1994

HUNTINGTON DISEASE WITHOUT CAG EXPANSION - PHENOCOPIES OR ERRORS IN ASSIGNMENT
American Journal of Human Genetics
ANDREW, SE and GOLDBERG, YP and KREMER, B and SQUITIERI, F and THEILMANN, J and ZEISLER, J and TELENIUS, H and ADAM, S and ALMQUIST, E and ANVRET, M and LUCOTTE, G and STOESS, AJ and CAMPANELLA, G and HAYDEN, MR
1994

HIGH-FREQUENCY OF MUTATIONS IN THE HUMAN LIPOPROTEIN-LIPASE GENE IN PREGNANCY-INDUCED CHYLOMICRONEMIA - POSSIBLE ASSOCIATION WITH APOLIPOPROTEIN E2 ISOFORM
Journal of Lipid Research
MA, YH and OOI, TC and LIU, MS and ZHANG, HF and MCPHERSON, R and EDWARDS, AL and FORSYTHE, IJ and FROHLICH, J and BRUNZELL, JD and HAYDEN, MR
1994

High frequency of mutations in the human lipoprotein lipase gene in pregnancy-induced chylomicronemia: Possible association with apolipoprotein E2 isoform
Journal of Lipid Research
Ma, Y. and Ooi, T.C. and Liu, M.-S. and Zhang, H. and McPherson, R. and Edwards, A.L. and Forsythe, I.J. and Frohlich, J. and Brunzell, J.D. and Hayden, M.R.
1994

Geographical distribution of haplotypes in Swedish families with Huntington's disease
Human Genetics
Almqvist, E. and Andrew, S. and Theilmann, J. and Goldberg, P. and Zeisler, J. and Drugge, U. and Grandell, U. and Tapper-Persson, M. and Winblad, B. and Hayden, M. and Anvret, M.
DOI: 10.1007/BF00202856
1994

A TRANSCRIPTION MAP OF THE HUNTINGTON DISEASE LOCUS
Cytogenetics and Cell Genetics
GOLDBERG, YP and ROMMENS, JR and HUTCHINSON, GB and ANDREW, SE and GRAHAM, RK and LIN, BY and THEILMANN, J and NASIR, J and KALCHMAN, MA and SHAPPERT, K and CLARKE, L and HAYDEN, MR
1994

A COMPOUND HETEROZYGOTE FOR LIPOPROTEIN-LIPASE DEFICIENCY, VAL(69)- LEU AND GLY(188)- GLU - CORRELATION BETWEEN IN-VITRO LPL ACTIVITY AND CLINICAL EXPRESSION
Journal of Lipid Research
Bruin, T. and Tuzgol, S. and Mulder, W. J. and Vandenende, A. E. and Jansen, H. and Hayden, M. R. and Kastelein, J. J. P.
1994

U-type exchange in a paracentric inversion as a possible mechanism of origin of an inverted tandem duplication of chromosome 8
American Journal of Medical Genetics
Mitchell, J.J. and Vekemans, M. and Luscombe, S. and Hayden, M. and Weber, B. and Richter, A. and Sparkes, R. and Kojis, T. and Watters, G. and Der Kaloustian, V.M.
DOI: 10.1002/ajmg.1320490406
1994

SOMATIC AND GONADAL MOSAICISM OF THE HUNTINGTON DISEASE GENE CAG REPEAT IN BRAIN AND SPERM (VOL 6, PG 409, 1994)
Nature Genetics
TELENIUS, H and KREMER, B and GOLDBERG, YP and THEILMANN, J and ANDREW, SE and ZEISLER, J and ADAM, S and GREENBERG, C and IVES, J and CLARKE, LA and HAYDEN, MR
1994

Sequence of the murine huntington dusease gene: Evidence for conservation, and polymorphism in a triplet (CCG) repeat alternate splicing
Human Molecular Genetics
Lin, B. and Nasir, J. and Macdonald, H. and Hutchinson, G. and Graham, R.K. and Rommesns, J.M. and Hayden, M.R.
DOI: 10.1093/hmg/3.1.85
1994

Regional cerebral glucose metabolism in huntington's disease: A statistical investigation
Human Brain Mapping
Clark, C.M. and Kremer, B. and Hayden, M.R.
DOI: 10.1002/hbm.460020109
1994

Precise mapping of the brain a2-Adrenergic receptor gene within chromosome 4p16
Genomics
Riess, O. and Thies, U. and Siedlaczck, I. and Potisek, S. and Graham, R. and Theilmann, J. and Grimm, T. and Epplen, J.T. and Hayden, M.R.
DOI: 10.1006/geno.1994.1061
1994

Normal CAG repeat length in the huntington’s disease gene in senile chorea
Neurology
Shinotoh, H. and Calne, D.B. and Snow, B. and Hayward, M. and Kremer, B. and Theilmann, J. and Hayden, M.R.
DOI: 10.1212/wnl.44.11.2183
1994

Murine a-l-Iduronidase: cDNA isolation and expression
Genomics
Clarke, L.A. and Nasir, J. and Zhang, H. and McDonald, H. and Applegarth, D.A. and Hayden, M.R. and Toone, J.
DOI: 10.1006/geno.1994.1621
1994

GEOGRAPHICAL-DISTRIBUTION OF HAPLOTYPES IN SWEDISH FAMILIES WITH HUNTINGTONS-DISEASE
Human Genetics
Almqvist, E. and Andrew, S. and Theilmann, J. and Goldberg, P. and Zeisler, J. and Drugge, U. and Grandell, U. and Tapperpersson, M. and Winblad, B. and Hayden, M. and Anvret, M.
1994

The murine homologues of the huntington disease gene (Hdh) and the a-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3
Genomics
Nasir, J. and Lin, B. and Bucan, M. and Koizumi, T. and Nadeau, J.H. and Hayden, M.R.
DOI: 10.1006/geno.1994.1361
1994

GENE ENVIRONMENT INTERACTION AND PLASMA TRIGLYCERIDE LEVELS - THE CRUCIAL ROLE OF LIPOPROTEIN-LIPASE
Clinical Genetics
HAYDEN, MR and LIU, MS and MA, YH
1994

FAMILIAL LATE-ONSET CHOREA (WITHOUT OTHER FEATURES) MAY BE HUNTINGTONS-DISEASE
Neurology
BRITTON, JW and UITTI, RJ and AHLSKOG, JE and ROBINSON, RG and KREMER, B and HAYDEN, MR
1994

DNA haplotype analysis of huntington disease reveals clues to the origins and mechanisms of CAG expansion and reasons for geographic variations of prevalence
Human Molecular Genetics
Squitieri, F. and Andrew, S.E. and Goldberg, Y.P. and Kremer, B. and Spence, N. and Zelsler, J. and Nichol, K. and Theilmann, J. and Greenberg, J. and Goto, J. and Kanazawa, I. and Vesa, J. and Peltonen, L. and Almqvist, E. and Anvret, M. and Telenius, H. and Lin, B. and Napolitano, G. and Morgan, K. and Hayden, M.R.
DOI: 10.1093/hmg/3.12.2103
1994

ALTERATION OF LIPID PROFILES IN PLASMA OF TRANSGENIC MICE EXPRESSING HUMAN LIPOPROTEIN-LIPASE
Journal of Biological Chemistry
LIU, MS and JIRIK, FR and LEBOEUF, RC and HENDERSON, H and CASTELLANI, LW and LUSIS, AJ and MA, YH and FORSYTHE, IJ and ZHANG, HF and KIRK, E and BRUNZELL, JD and HAYDEN, MR
1994

A MUTATION (N291S) IN THE LPL GENE OCCURS WITH INCREASED FREQUENCY IN PATIENTS WITH PREMATURE ATHEROSCLEROSIS AND HYPERLIPIDEMIA
Circulation
REYMER, PWA and GAGNE, E and GROENEMEYER, BE and MA, YH and APPLEMAN, EEG and VANDEROEVER, K and BRUIN, T and SEIDEL, JC and KASTELEIN, JJP and HAYDEN, MR
1994

Recurrent missense mutations at the first and second base of codon Arg²⁴³ in human lipoprotein lipase in patients of different ancestries
Human Mutation
Ma, Y. and Liu, M.?S. and Chitayat, D. and Bruin, T. and Beisiegel, U. and Benlian, P. and Foubert, L. and De Gennes, J.L. and Funke, H. and Forsythe, I. and Blaichman, S. and Papanikolaou, M. and Erkelens, D.W. and Kastelein, J. and Brunzell, J.D. and Hayden, M.R.
DOI: 10.1002/humu.1380030109
1994

PROCEED WITH CARE - DIRECT PREDICTIVE TESTING FOR HUNTINGTON DISEASE
American Journal of Human Genetics
BENJAMIN, CM and ADAM, S and WIGGINS, S and THEILMANN, JL and COPLEY, TT and BLOCH, M and SQUITIERI, F and MCKELLIN, W and COX, S and BROWN, SA and KREMER, HPH and BURGESS, M and MESHINO, W and SUMMERS, A and MACGREGOR, D and BUCHANAN, J and GREENBERG, C and CARSON, N and IVES, E and FRECKER, M and WELCH, JP and FULLER, A and ROSENBLATT, D and MILLER, S and DUFRASNE, S and ROY, M and ANDERMANN, E and PREVOST, C and KHALIFA, M and GIRARD, K and TAYLOR, S and HUNTER, A and GOLDSMITH, C and WHELAN, D and EISENBERG, D and SOLTAN, H and KANE, J and SHOKEIR, MHK and GIBSON, A and CARDWELL, S and BAMFORTH, S and GROVER, S and SUCHOWERSKY, O and KLIMEK, M and GARBER, T and GARDNER, HA and MACLEOD, P and HAYDEN, MR
1994

Erratum: Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm (Nature Genetics (1994) 6 (409-413))
Nature Genetics
Telenius, H. and Kremer, B. and Goldberg, Y.P. and Theilmann, J. and Andrew, S.E. and Zeisler, J. and Adam, S. and Greenberg, C. and Ives, E.J. and Clarke, L.A. and Hayden, M.R.
DOI: 10.1038/ng0594-113b
1994

Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia
The American Journal of Cardiology
Davignon, J. and Roederer, G. and Montigny, M. and Hayden, M.R. and Tan, M.-H. and Connelly, P.W. and Hegele, R. and McPherson, R. and Lupien, P.J. and Gagné, C. and Little, J.A. and Colin, P.
DOI: 10.1016/0002-9149(94)90005-1
1994

Apolipoprotein CII-Padova (Tyr³⁷¿stop) as a cause of chylomicronaemia in an Italian kindred from Siculiana
Journal of Medical Genetics
Tuzgol, S. and Bijvoet, S.M. and Bruin, T. and Kastelein, J.J.P. and Hayden, M.R.
1994

NORMAL CAG REPEAT LENGTH IN THE HUNTINGTONS-DISEASE GENE IN SENILE CHOREA
Neurology
SHINOTOH, H and CALNE, DB and SNOW, B and HAYWARD, M and KREMER, B and THEILMANN, J and HAYDEN, MR
1994

MUTAGENESIS IN 4 CANDIDATE HEPARIN-BINDING REGIONS (RESIDUE-279-282, RESIDUE-291-304, RESIDUE-390-393, AND RESIDUE-439-448) AND IDENTIFICATION OF RESIDUES AFFECTING HEPARIN-BINDING OF HUMAN LIPOPROTEIN-LIPASE
Journal of Lipid Research
MA, YH and HENDERSON, HE and LIU, MS and ZHANG, HF and FORSYTHE, IJ and CLARKELEWIS, I and HAYDEN, MR and BRUNZELL, JD
1994

Issues in molecular genetic testing of individuals with suspected early-onset familial Alzheimer's disease
Alzheimer Disease and Associated Disorders
Karlinsky, H. and Sadovnick, A.D. and Burgess, M.M. and Langlois, S. and Hayden, M.R. and Berg, J.M.
DOI: 10.1097/00002093-199408020-00008
1994

IN-VITRO MUTAGENESIS STUDIES DEFINES THOSE RESIDUES OF LIPOPROTEIN-LIPASE CRITICAL FOR MEDIATION OF THE BINDING OF LIPOPROTEINS TO THE LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP)
Circulation
ZHANG, HF and KRAPP, A and MA, YH and GINZINGER, DG and BEISIEGEL, U and HAYDEN, MR
1994

A CCG repeat polymorphism adjacent to the CAG repeat in the huntington disease gene: Implications for diagnostic accuracy and predictive testing
Human Molecular Genetics
Andrew, S.E. and Goldberg, Y.P. and Theilmann, J. and Zeisler, J. and Hayden, M.R.
DOI: 10.1093/hmg/3.1.65
1994

THE MOLECULAR-GENETICS OF HUNTINGTONS-DISEASE
Current Opinion in Neurology
GOLDBERG, YP and TELENIUS, H and HAYDEN, MR
1994

Huntington disease without CAG expansion: Phenocopies or errors in assignment?
American Journal of Human Genetics
Andrew, S.E. and Paul Goldberg, Y. and Kremer, B. and Squitieri, F. and Theilmann, J. and Zeisler, J. and Telenius, H. and Adam, S. and Almquist, E. and Anvret, M. and Lucotte, G. and Jon Stoessl, A. and Campanella, G. and Hayden, M.R.
1994

GUIDELINES FOR THE MOLECULAR-GENETICS PREDICTIVE TEST IN HUNTINGTONS-DISEASE
Neurology
Broholm, J. and Cassiman, J. J. and Craufurd, D. and Falek, A. and Farmerlittle, C. and Hayden, M. and Kapp, R. and Krahnen, K. and Martinezdescals, A. and Mol, M. and Myrianthopoulos, N. and Petit, H. and Quaid, K. and Desomviele, C. and Taylor, E. and Tyler, A. and Walker, R. and Went, L. and Wexler, N.
1994

APOLIPOPROTEIN CII-PADOVA (TYR(37)-]STOP) AS A CAUSE OF CHYLOMICRONEMIA IN AN ITALIAN KINDRED FROM SICULIANA
Journal of Medical Genetics
TUZGOL, S and BIJVOET, SM and BRUIN, T and KASTELEIN, JJP and HAYDEN, MR
DOI: 10.1136/jmg.31.8.622
1994

The molecular genetics of Huntington's disease
Current Opinion in Neurology
Goldberg, Y.P. and Telenius, H. and Hayden, M.R.
DOI: 10.1097/00019052-199408000-00009
1994

Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm
Nature Genetics
Telenius, H. and Kremer, B. and Goldberg, Y.P. and Theilmann, J. and Andrew, S.E. and Zeisler, J. and Adam, S. and Greenberg, C. and Ives, E.J. and Clarke, L.A. and Hayden, M.R.
DOI: 10.1038/ng0494-409
1994

Sequence of the murine huntington disease gene: Evidence for conservation, alternate splicing and polymorphism in a triplet (ccg) repeat
Human Molecular Genetics
Lin, B. and Nasir, J. and Macdonald, H. and Hutchinson, G. and Graham, R.K. and Rommens, J.M. and Hayden, M.R.
DOI: 10.1093/hmg/3.3.530-a
1994

Proceed with Care: Direct Predictive Testing for Huntington Disease
American Journal of Human Genetics
Benjamin, C.M. and Adam, S. and Wiggins, S. and Theilmann, J.L. and Copley, T.T. and Bloch, M. and Squitieri, F. and McKellin, W. and Cox, S. and Brown, S.A. and Kremer, H.P.H. and Burgess, M. and Meshino, W. and Summers, A. and Macgregor, D. and Buchanan, J. and Greenberg, C. and Carson, N. and Ives, E. and Frecker, M. and Welch, J.P. and Fuller, A. and Rosenblatt, D. and Miller, S. and Dufrasne, S. and Roy, M. and Andermann, E. and Prevost, C. and Khalifa, M. and Girard, K. and Taylor, S. and Hunter, A. and Goldsmith, C. and Whelan, D. and Eisenberg, D. and Soltan, H. and Kane, J. and Shokeir, M.H.K. and Gibson, A. and Cardwell, S. and Banforth, S. and Grover, S. and Suchowersky, O. and Klimek, M. and Garber, T. and Gardner, H.A. and MacLeod, P. and Hayden, M.R.
1994

Gene environment interaction and plasma triglyceride levels: the crucial role of lipoprotein lipase
Clinical Genetics
Hayden, M.R. and Liu, M.?S. and Ma, Y.
DOI: 10.1111/j.1399-0004.1994.tb04197.x
1994

Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia
Arteriosclerosis, Thrombosis, and Vascular Biology
Gagné, E. and Genest Jr., J. and Zhang, H. and Clarke, L.A. and Hayden, M.R.
DOI: 10.1161/01.ATV.14.8.1250
1994