- Overview
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Our research specifically explores how proteins within the endometrium behave to improve our understanding of maternal and infant health.
- Publications
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Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women
Frontiers in Immunology
Salker, M.S. and Abd Aziz, N.H. and Prodan, N.C. and Yang, Z. and Lankapalli, A.K. and Lazar, K. and Shafiee, M.N. and Kocak, E. and Ganesan, H. and Pal, S.S. and Khalid, O. and Kasim, N.M. and Kalok, A. and Fuad, N.A. and Bissinger, A.L. and Ganzenmueller, T. and Iftner, T. and Kagan, K.O. and Ossowski, S. and Casadei, N. and Brucker, S.Y. and Riess, O. and Singh, Y.
DOI: 10.3389/fimmu.2025.1560391
2025Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
Clinical Science
Liu, A. and Ruetalo, N. and Raja Xavier, J.P. and Lankapalli, A.K. and Admard, J. and Camarena-Sainz, M. and Brucker, S.Y. and Singh, Y. and Schindler, M. and Salker, M.S.
DOI: 10.1042/CS20241215
2025Inhibition of placental trophoblast fusion by guanylate-binding protein 5
Science Advances
Krchlikova, V. and Braun, E. and Weiss, J. and Stafl, K. and Jech, L. and Badarinarayan, S.S. and Lotke, R. and Travnicek, M. and Baur, C. and Stark, P. and Haussmann, I. and Lu, Y. and Petersen, M. and Cui, W. and Wang, W. and F{\"a}ger, B.M. and Reisinger, H. and Tokunaga, K. and Cing{\"o}z, O. and Sparrer, K.M.J. and Salker, M.S. and Hejnar, J. and Kirchhoff, F. and Trejbalova, K. and Sauter, D.
DOI: 10.1126/sciadv.adt5388
2025Optimizing the use of in vitro transcribed SGK1-mRNA as a therapeutic tool to treat female infertility
BMC Research Notes
Sahu, I. and Engelmann, F. and Weidensee, B. and Ganesan, H. and Brucker, S.Y. and Singh, Y. and Salker, M.S.
DOI: 10.1186/s13104-025-07346-5
2025Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2
Frontiers in Cell and Developmental Biology
Yang, Z. and Yan, J. and Kull, S. and Alauddin, M. and Brucker, S.Y. and Henes, M. and Lang, F. and Salker, M.S.
DOI: 10.3389/fcell.2025.1499339
2025Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development
Biological Research
Raja Xavier, J.P. and Okumura, T. and Apweiler, M. and Chacko, N.A. and Singh, Y. and Brucker, S.Y. and Takeda, S. and Lang, F. and Salker, M.S.
DOI: 10.1186/s40659-024-00526-w
2024Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1a Activity in Ishikawa and HEC1a Cells
International Journal of Molecular Sciences
Okumura, T. and Raja Xavier, J.P. and Pasternak, J. and Yang, Z. and Hang, C. and Nosirov, B. and Singh, Y. and Admard, J. and Brucker, S.Y. and Kommoss, S. and Takeda, S. and Staebler, A. and Lang, F. and Salker, M.S.
DOI: 10.3390/ijms25073666
2024Excessive endometrial PlGF- Rac1 signalling underlies endometrial cell stiffness linked to pre-eclampsia
Communications Biology
Raja Xavier, J.P. and Rianna, C. and Hellwich, E. and Nikolou, I. and Lankapalli, A.K. and Brucker, S.Y. and Singh, Y. and Lang, F. and Sch{\"a}ffer, T.E. and Salker, M.S.
DOI: 10.1038/s42003-024-06220-7
2024Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placenta
Proceedings of the National Academy of Sciences of the United States of America
?tafl, K. and Tr{\'a}vn{\'i}?ek, M. and Janovsk{\'a}, A. and Ku?erov{\'a}, D. and Pecnov{\'a}, ?. and Yang, Z. and Stepanec, V. and Jech, L. and Salker, M.S. and Hejnar, J. and Trejbalov{\'a}, K.
DOI: 10.1073/pnas.2407519121
2024Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease
Molecular Neurodegeneration
Singh, Y. and Trautwein, C. and Romani, J. and Salker, M.S. and Neckel, P.H. and Fraccaroli, I. and Abeditashi, M. and Woerner, N. and Admard, J. and Dhariwal, A. and Dueholm, M.K.D. and Sch{\"a}fer, K.-H. and Lang, F. and Otzen, D.E. and Lashuel, H.A. and Riess, O. and Casadei, N.
DOI: 10.1186/s13024-023-00628-1
2023Dysregulated Exosomes Result in Suppression of the Immune Response of Pregnant COVID-19 Convalescent Women
Frontiers in Molecular Biosciences
Cao, H. and Abd Aziz, N.H. and Xavier, J.R. and Shafiee, M.N. and Kalok, A. and Jee, B. and Salker, M.S. and Singh, Y.
DOI: 10.3389/fmolb.2022.869192
2022SARS-CoV-2 Infection in Pregnancy: Placental Histomorphological Patterns, Disease Severity and Perinatal Outcomes
International Journal of Environmental Research and Public Health
Wong, Y.P. and Tan, G.C. and Omar, S.Z. and Mustangin, M. and Singh, Y. and Salker, M.S. and Abd Aziz, N.H. and Shafiee, M.N.
DOI: 10.3390/ijerph19159517
2022Immune dynamics at single cell protein level after delta/omicron infection in COVID-19 vaccinated convalescent individuals
Biorxiv
Bajaj, R. and Yang, Z. and Hammer, V. and P{\"o}schel, S. and Bieber, K. and Salker, M.S. and Casadei, N. and Ossowski, S. and Riess, O. and Singh, Y.
DOI: 10.1101/2022.09.05.506626
2022Comparative multi-OMICS single cell atlas of five COVID-19 (rAdVV and mRNA) vaccines describe unique and distinct mechanisms of action
Biorxiv
Singh, Y. and Selting, A.S. and Gabernet, G. and Ray, U. and Bajaj, R. and Ali, M. and Loitz, M. and Hammer, V. and Buena-Atienza, E. and Ruschil, C. and Huebener-Schmid, J. and Kowarik, M. and Salker, M.S. and Casadei, N. and Nahnsen, S. and Kremsner, P. and Ossowski, S. and Altmann, D.M. and Riess, O.
DOI: 10.1101/2022.09.12.507666
2022Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cells in recovered COVID-19 pregnant women
Biorxiv
Aziz, N.H.A. and Salker, M.S. and Lankapalli, A.K. and Shafiee, M.N. and Kocak, E. and Pal, S.S. and Khalid, O. and Kasim, N.M. and Kalok, A. and Fuad, N.A. and Ossowski, S. and Casadei, N. and Brucker, S.Y. and Riess, O. and Singh, Y.
DOI: 10.1101/2022.08.18.504053
2022Molecular and Physiological Aspects of SARS-CoV-2 Infection in Women and Pregnancy
Frontiers in Global Women S Health
Liu, A. and Raja xavier, J. and Singh, Y. and Brucker, S.Y. and Salker, M.S.
DOI: 10.3389/fgwh.2022.756362
2022Marker-free imaging of a-Synuclein aggregates in a rat model of Parkinson’s disease using Raman microspectroscopy
Fide Sevgi and Eva M Brauchle and Daniel A Carvajal Berrio and Katja Schenke-Layland and Nicolas Casadei and Madhuri S Salker and Olaf Riess and Yogesh Singh
DOI: 10.1101/2021.02.02.429468
02/2021Imaging of a-Synuclein Aggregates in a Rat Model of Parkinson’s Disease Using Raman Microspectroscopy
Frontiers in Cell and Developmental Biology
Sevgi, F. and Brauchle, E.M. and Carvajal Berrio, D.A. and Schenke-Layland, K. and Casadei, N. and Salker, M.S. and Riess, O. and Singh, Y.
DOI: 10.3389/fcell.2021.664365
2021Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function
Frontiers in Nutrition
Singh, Y. and Salker, M.S. and Lang, F.
DOI: 10.3389/fnut.2020.616934
2021The putative role of 1,25(OH)2D3 in the association of milk consumption and Parkinson’s disease
Neurosignals
Lang, F. and Ma, K. and Leibrock, C.B. and Salker, M.S. and Singh, Y.
DOI: 10.33594/000000321
2021SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells
Yogesh Singh and Christoph Trautwein and Rolf Fendel and Naomi Krickeberg and Georgy Berezhnoy and Rosi Bissinger and Stephan Ossowski and Madhuri S. Salker and Nicolas Casadei and Olaf Riess
DOI: 10.1101/2020.09.04.282780
09/2020Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
Molecular Nutrition and Food Research
Alauddin, M. and Okumura, T. and Rajaxavier, J. and Khozooei, S. and P{\"o}schel, S. and Takeda, S. and Singh, Y. and Brucker, S.Y. and Wallwiener, D. and Koch, A. and Salker, M.S.
DOI: 10.1002/mnfr.201900390
2020Annexin A7 Regulates Endometrial Receptivity
Frontiers in Cell and Developmental Biology
Alauddin, M. and Salker, M.S. and Umbach, A.T. and Rajaxavier, J. and Okumura, T. and Singh, Y. and Wagner, A. and Brucker, S.Y. and Wallwiener, D. and Brosens, J.J. and Lang, F.
DOI: 10.3389/fcell.2020.00770
2020Glucose transport in lymphocytes
Pflugers Archiv European Journal of Physiology
Lang, F. and Singh, Y. and Salker, M.S. and Ma, K. and Pandyra, A.A. and Lang, P.A. and Lang, K.S.
DOI: 10.1007/s00424-020-02416-y
2020LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells
Plos One
Zeng, N. and Okumura, T. and Alauddin, M. and Khozooei, S. and Rajaxavier, J. and Zhang, S. and Singh, Y. and Shi, B. and Brucker, S.Y. and Wallwiener, D. and Takeda, S. and Lang, F. and Salker, M.S.
DOI: 10.1371/journal.pone.0230044
2020DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)
Scientific Reports
Singh, Y. and Trautwein, C. and Dhariwal, A. and Salker, M.S. and Alauddin, M. and Zizmare, L. and Pelzl, L. and Feger, M. and Admard, J. and Casadei, N. and F{\"o}ller, M. and Pachauri, V. and Park, D.S. and Mak, T.W. and Frick, J.-S. and Wallwiener, D. and Brucker, S.Y. and Lang, F. and Riess, O.
DOI: 10.1038/s41598-020-72903-w
2020Point-of-care-ready nanoscale ISFET arrays for sub-picomolar detection of cytokines in cell cultures
Analytical and Bioanalytical Chemistry
Rani, D. and Singh, Y. and Salker, M. and Vu, X.T. and Ingebrandt, S. and Pachauri, V.
DOI: 10.1007/s00216-020-02820-4
2020The Enigmatic Role of Serum & Glucocorticoid Inducible Kinase 1 in the Endometrium
Frontiers in Cell and Developmental Biology
Lang, F. and Rajaxavier, J. and Singh, Y. and Brucker, S.Y. and Salker, M.S.
DOI: 10.3389/fcell.2020.556543
2020DJ-1 (Park7) affects the gut microbiome, metabolites and development of Innate Lymphoid cells (ILCs)
Biorxiv
Singh, Y. and Trautwein, C. and Dhariwal, A. and Salker, M.S. and Alauddin, M. and Zigmare, L. and Pelzl, L. and Feger, M. and Matthes, J. and Casadei, N. and F{\"o}ller, M. and Pachauri, V. and Park, D.S. and Mak, T.W. and Frick, J.S. and Wallwiener, D. and Brucker, S.Y. and Lang, F. and Riess, O.
DOI: 10.1101/776005
2019Raman imaging of a-synuclein aggregates in a rat model of Parkinson's disease
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Brauchle, E. and Sevgi, F. and Berrio, D.C. and Schenke-Layland, K. and Casadei, N. and Riess, O. and Salker, M.S. and Singh, Y.
DOI: 10.1117/12.2509751
2019Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p
Frontiers in Immunology
Zhang, S. and Al-Maghout, T. and Cao, H. and Pelzl, L. and Salker, M.S. and Veldhoen, M. and Cheng, A. and Lang, F. and Singh, Y.
DOI: 10.3389/fimmu.2019.01737
2019Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival
Apoptosis
Bissinger, R. and Lang, E. and Gonzalez-Menendez, I. and Quintanilla-Martinez, L. and Ghashghaeinia, M. and Pelzl, L. and Sukkar, B. and Bhuyan, A.A.M. and Salker, M.S. and Singh, Y. and Fehrenbacher, B. and Fakhri, H. and Umbach, A.T. and Schaller, M. and Qadri, S.M. and Lang, F.
DOI: 10.1007/s10495-018-1481-8
2018LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry
Journal of Molecular Medicine
Salker, M.S. and Singh, Y. and Durairaj, R.R.P. and Yan, J. and Alauddin, M. and Zeng, N. and Steel, J.H. and Zhang, S. and Nautiyal, J. and Webster, Z. and Brucker, S.Y. and Wallwiener, D. and Anne Croy, B. and Brosens, J.J. and Lang, F.
DOI: 10.1007/s00109-017-1610-9
2018Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts
Oncotarget
Zhang, S. and Al-Maghout, T. and Bissinger, R. and Zeng, N. and Pelzl, L. and Salker, M.S. and Cheng, A. and Singh, Y. and Lang, F.
DOI: 10.18632/oncotarget.20032
2017Negative effect of ellagic acid on cytosolic ph regulation and glycolytic flux in human endometrial cancer cells
Cellular Physiology and Biochemistry
Abdelazeem, K.N.M. and Singh, Y. and Lang, F. and Salker, M.S.
DOI: 10.1159/000475655
2017Enhanced Reactive Oxygen Species Production, Acidic Cytosolic pH and Upregulated Na + /H + Exchanger (NHE) in Dicer Deficient CD4 + T Cells
Cellular Physiology and Biochemistry
Singh, Y. and Zhou, Y. and Zhang, S. and Abdelazeem, K.N.M. and Elvira, B. and Salker, M.S. and Lang, F.
DOI: 10.1159/000479201
20171a,25(OH) 2 D 3 Sensitive Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Ishikawa Cells
Cellular Physiology and Biochemistry
Zeng, N. and Zhou, Y. and Zhang, S. and Singh, Y. and Shi, B. and Salker, M.S. and Lang, F.
DOI: 10.1159/000458427
2017Decidualization is Impaired in Endometrial Stromal Cells from Uterine Rudiments in Mayer-Rokitansky-Küster-Hauser Syndrome
Cellular Physiology and Biochemistry
Brucker, S.Y. and Eisenbeis, S. and K{\"o}nig, J. and Lamy, M. and Salker, M.S. and Zeng, N. and Seeger, H. and Henes, M. and Sch{\"o}ller, D. and Sch{\"o}nfisch, B. and Staebler, A. and Taran, F.-A. and Wallwiener, D. and Rall, K.
DOI: 10.1159/000464116
2017DJ-1/Park7 Sensitive Na+/H+ Exchanger 1 (NHE1) in CD4+ T Cells
Journal of Cellular Physiology
Zhou, Y. and Shi, X. and Chen, H. and Zhang, S. and Salker, M.S. and Mack, A.F. and F{\"o}ller, M. and Mak, T.W. and Singh, Y. and Lang, F.
DOI: 10.1002/jcp.25516
2017SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice
Cellular Physiology and Biochemistry
Sharma, P. and Khairnar, V. and Maduni?, I.V. and Singh, Y. and Pandyra, A. and Salker, M.S. and Koepsell, H. and Saboli?, I. and Lang, F. and Lang, P.A. and Lang, K.S.
DOI: 10.1159/000479197
2017Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy
Scientific Reports
Salker, M.S. and Singh, Y. and Zeng, N. and Chen, H. and Zhang, S. and Umbach, A.T. and Fakhri, H. and Kohlhofer, U. and Quintanilla-Martinez, L. and Durairaj, R.R.P. and Barros, F.S.V. and Vrljicak, P. and Ott, S. and Brucker, S.Y. and Wallwiener, D. and Maduni?, I.V. and Breljak, D. and Saboli?, I. and Koepsell, H. and Brosens, J.J. and Lang, F.
DOI: 10.1038/s41598-017-11674-3
2017Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells
PLoS ONE
Zhang, S. and Zeng, N. and Alowayed, N. and Singh, Y. and Cheng, A. and Lang, F. and Salker, M.S.
DOI: 10.1371/journal.pone.0183681
20171a,25(OH) 2 D 3 Induces Actin Depolymerization in Endometrial Carcinoma Cells by Targeting RAC1 and PAK1
Cellular Physiology and Biochemistry
Zeng, N. and Salker, M.S. and Zhang, S. and Singh, Y. and Shi, B. and Stournaras, C. and Lang, F.
DOI: 10.1159/000453197
2016Prolyl hydroxylase 3 (PHD3) expression augments the development of regulatory T cells
Molecular Immunology
Singh, Y. and Shi, X. and Zhang, S. and Umbach, A.T. and Chen, H. and Salker, M.S. and Lang, F.
DOI: 10.1016/j.molimm.2016.06.003
2016Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4 + T Cells
Cellular Physiology and Biochemistry
Zhang, S. and Al-Maghout, T. and Zhou, Y. and Bissinger, R. and Abousaab, A. and Salker, M.S. and Pelzl, L. and Cobb, B.S. and Cheng, A. and Singh, Y. and Lang, F.
DOI: 10.1159/000447840
2016Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation
Cellular Physiology and Biochemistry
Salker, M.S. and Steel, J.H. and Hosseinzadeh, Z. and Nautiyal, J. and Webster, Z. and Singh, Y. and Brucker, S. and Lang, F. and Brosens, J.J.
DOI: 10.1159/000447903
2016Up-regulation of FGF23 release by aldosterone
Biochemical and Biophysical Research Communications
Zhang, B. and Umbach, A.T. and Chen, H. and Yan, J. and Fakhri, H. and Fajol, A. and Salker, M.S. and Spichtig, D. and Daryadel, A. and Wagner, C.A. and F{\"o}ller, M. and Lang, F.
DOI: 10.1016/j.bbrc.2016.01.034
2016ß-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2
Cellular Physiology and Biochemistry
Abousaab, A. and Warsi, J. and Salker, M.S. and Lang, F.
DOI: 10.1159/000453146
2016NF¿B-sensitive Orai1 expression in the regulation of FGF23 release
Journal of Molecular Medicine
Zhang, B. and Yan, J. and Umbach, A.T. and Fakhri, H. and Fajol, A. and Schmidt, S. and Salker, M.S. and Chen, H. and Alexander, D. and Spichtig, D. and Daryadel, A. and Wagner, C.A. and F{\"o}ller, M. and Lang, F.
DOI: 10.1007/s00109-015-1370-3
2016LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a
Cellular Physiology and Biochemistry
Alowayed, N. and Salker, M.S. and Zeng, N. and Singh, Y. and Lang, F.
DOI: 10.1159/000447792
2016LEFTYA Activates the Epithelial Na + Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1
Cellular Physiology and Biochemistry
Salker, M.S. and Hosseinzadeh, Z. and Alowayed, N. and Zeng, N. and Umbach, A.T. and Webster, Z. and Singh, Y. and Brosens, J.J. and Lang, F.
DOI: 10.1159/000447834
2016Alkaline cytosolic ph and high sodium hydrogen exchanger 1 (NHE1) activity in Th9 cells
Journal of Biological Chemistry
Singh, Y. and Zhou, Y. and Shi, X. and Zhang, S. and Umbach, A.T. and Salker, M.S. and Lang, K.S. and Lang, F.
DOI: 10.1074/jbc.M116.730259
2016Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development
Cellular Physiology and Biochemistry
Zhou, Y. and Salker, M.S. and Walker, B. and M{\"u}nzer, P. and Borst, O. and Gawaz, M. and Gulbins, E. and Singh, Y. and Lang, F.
DOI: 10.1159/000447806
2016LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells
Scientific Reports
Salker, M.S. and Schierbaum, N. and Alowayed, N. and Singh, Y. and Mack, A.F. and Stournaras, C. and Sch{\"a}ffer, T.E. and Lang, F.
DOI: 10.1038/srep29370
2016Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2
Scientific Reports
Lang, E. and Bissinger, R. and Fajol, A. and Salker, M.S. and Singh, Y. and Zelenak, C. and Ghashghaeinia, M. and Gu, S. and Jilani, K. and Lupescu, A. and Reyskens, K.M.S.E. and Ackermann, T.F. and F{\"o}ller, M. and Schleicher, E. and Sheffield, W.P. and Arthur, J.S.C. and Lang, F. and Qadri, S.M.
DOI: 10.1038/srep17316
2015LeftyA sensitive cytosolic pH regulation and glycolytic flux in Ishikawa human endometrial cancer cells
Biochemical and Biophysical Research Communications
Salker, M.S. and Zhou, Y. and Singh, Y. and Brosens, J. and Lang, F.
DOI: 10.1016/j.bbrc.2015.03.120
2015Enhanced suicidal erythrocyte death contributing to anemia in the elderly
Cellular Physiology and Biochemistry
Lupescu, A. and Bissinger, R. and Goebel, T. and Salker, M.S. and Alzoubi, K. and Liu, G. and Chirigiu, L. and Mack, A.F. and Qadri, S.M. and Lang, F.
DOI: 10.1159/000430137
2015SPAK sensitive regulation of the epithelial Na+ channel ENaC
Kidney and Blood Pressure Research
Ahmed, M. and Salker, M.S. and Elvira, B. and Umbach, A.T. and Fakhri, H. and Saeed, A.M. and Shumilina, E. and Hosseinzadeh, Z. and Lang, F.
DOI: 10.1159/000368509
2015SPAK and OSR1 sensitivity of excitatory amino acid transporter EAAT3
Nephron
Borr{\'a}s, J. and Salker, M.S. and Elvira, B. and Warsi, J. and Fezai, M. and Hoseinzadeh, Z. and Lang, F.
DOI: 10.1159/000433567
2015Lithium-Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release
NeuroSignals
Zhang, B. and Yan, J. and Schmidt, S. and Salker, M.S. and Alexander, D. and F{\"o}ller, M. and Lang, F.
DOI: 10.1159/000442602
2015Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells
Scientific Reports
Singh, Y. and Chen, H. and Zhou, Y. and F{\"o}ller, M. and Mak, T.W. and Salker, M.S. and Lang, F.
DOI: 10.1038/srep17723
2015Uterine selection of human embryos at implantation
Scientific Reports
Brosens, J.J. and Salker, M.S. and Teklenburg, G. and Nautiyal, J. and Salter, S. and Lucas, E.S. and Steel, J.H. and Christian, M. and Chan, Y.-W. and Boomsma, C.M. and Moore, J.D. and Hartshorne, G.M. and ?u?urovi?, S. and Mulac-Jericevic, B. and Heijnen, C.J. and Quenby, S. and Groot Koerkamp, M.J. and Holstege, F.C.P. and Shmygol, A. and Macklon, N.S.
DOI: 10.1038/srep03894
2014SPAK dependent regulation of peptide transporters PEPT1 and PEPT2
Kidney and Blood Pressure Research
Warsi, J. and Dong, L. and Elvira, B. and Salker, M.S. and Shumilina, E. and Hosseinzadeh, Z. and Lang, F.
DOI: 10.1159/000368451
2014Induction of 11ß-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells
Molecular Endocrinology
Kuroda, K. and Venkatakrishnan, R. and Salker, M.S. and Lucas, E.S. and Shaheen, F. and Kuroda, M. and Blanks, A. and Christian, M. and Quenby, S. and Brosens, J.J.
DOI: 10.1210/me.2012-1247
2013Reprint of: Uterine plasticity and reproductive fitness
Reproductive BioMedicine Online
Lucas, E.S. and Salker, M.S. and Brosens, J.J.
DOI: 10.1016/j.rbmo.2013.10.003
2013Uterine plasticity and reproductive fitness
Reproductive BioMedicine Online
Lucas, E.S. and Salker, M.S. and Brosens, J.J.
DOI: 10.1016/j.rbmo.2013.06.012
2013SGK1: A therapeutic target to prevent reproductive failure?
Expert Review of Obstetrics and Gynecology
Salker, M.S. and Quenby, S. and Brosens, J.J.
DOI: 10.1586/eog.12.1
2012Molecular aspects of implantation failure
Biochimica et Biophysica Acta - Molecular Basis of Disease
Koot, Y.E.M. and Teklenburg, G. and Salker, M.S. and Brosens, J.J. and Macklon, N.S.
DOI: 10.1016/j.bbadis.2012.05.017
2012Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss
PLoS ONE
Salker, M.S. and Nautiyal, J. and Steel, J.H. and Webster, Z. and ?u?urovi?, S. and Nicou, M. and Singh, Y. and Lucas, E.S. and Murakami, K. and Chan, Y.-W. and James, S. and Abdallah, Y. and Christian, M. and Croy, B.A. and Mulac-Jericevic, B. and Quenby, S. and Brosens, J.J.
DOI: 10.1371/journal.pone.0052252
2012Deregulation of the serum-and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure
Nature Medicine
Salker, M.S. and Christian, M. and Steel, J.H. and Nautiyal, J. and Lavery, S. and Trew, G. and Webster, Z. and Al-Sabbagh, M. and Puchchakayala, G. and F{\"o}ller, M. and Landles, C. and Sharkey, A.M. and Quenby, S. and Aplin, J.D. and Regan, L. and Lang, F. and Brosens, J.J.
DOI: 10.1038/nm.2498
2011The molecular basis of recurrent pregnancy loss: Impaired natural embryo selection
Molecular Human Reproduction
Teklenburg, G. and Salker, M. and Heijnen, C. and Macklon, N.S. and Brosens, J.J.
DOI: 10.1093/molehr/gaq079
2010Natural selection of human embryos: Impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
PLoS ONE
Salker, M. and Teklenburg, G. and Molokhia, M. and Lavery, S. and Trew, G. and Aojanepong, T. and Mardon, H.J. and Lokugamage, A.U. and Rai, R. and Landles, C. and Roelen, B.A.J. and Quenby, S. and Kuijk, E.W. and Kavelaars, A. and Heijnen, C.J. and Regan, L. and Macklon, N.S. and Brosens, J.J.
DOI: 10.1371/journal.pone.0010287
2010Natural selection of human embryos: Decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation
PLoS ONE
Teklenburg, G. and Salker, M. and Molokhia, M. and Lavery, S. and Trew, G. and Aojanepong, T. and Mardon, H.J. and Lokugamage, A.U. and Rai, R. and Landles, C. and Roelen, B.A.J. and Quenby, S. and Kuijk, E.W. and Kavelaars, A. and Heijnen, C.J. and Regan, L. and Brosens, J.J. and Macklon, N.S.
DOI: 10.1371/journal.pone.0010258
2010Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis
Molecular Human Reproduction
Brosens, J.J. and Hodgetts, A. and Feroze-Zaidi, F. and Sherwin, J.R.A. and Fusi, L. and Salker, M.S. and Higham, J. and Rose, G.L. and Kajihara, T. and Young, S.L. and Lessey, B.A. and Henriet, P. and Langford, P.R. and Fazleabas, A.T.
DOI: 10.1093/molehr/gap108
2009Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium
Endocrinology
Feroze-Zaidi, F. and Fusi, L. and Takano, M. and Higham, J. and Salker, M.S. and Goto, T. and Edassery, S. and Klingel, K. and Boini, K.M. and Palmada, M. and Kamps, R. and Groothuis, P.G. and Lam, E.W.-F. and Smith, S.K. and Lang, F. and Sharkey, A.M. and Brosens, J.J.
DOI: 10.1210/en.2007-0659
2007Closure of the posterior neuropore in the vl mutant mouse.
Anatomy and embryology
DOI: 10.1007/bf00305044
PubMed: 3223614
01/1988 - Research
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Developing ML prediction models for the identification of adverse maternal and neonatal outcomes
Stillbirth is often referred to as a ‘silent epidemic’ accounting for the fifth leading global cause of deaths (when compared with causes of death in all ages)-outranking cancer, tuberculosis (TB) and HIV. That is: losing 5 precious babies each minute. The rate in Canada remains high at 8.9 per 1,000 births- which has not reduced in 20 years. Stillbirths including maternal death rates are significantly higher for First Nations and Inuit populations in Canada compared to non-Aboriginal populations and, in low- and middle-income countries (LMICs), mainly related to lack of health infrastructure and clinical monitoring during pregnancy. Despite of such socio-economic disparities most cases are associated with a missed or delayed diagnosis. Therefore, there is an urgent critical need to discover novel biomarkers (prognostic and predictive) that enable diagnosis of adverse gestational outcomes (APO) earlier.Evaluating the endometrial microenvironment stiffness and pre-eclampsia
Pregnancy is dependent on the transformation of the endometrium, a process driven by the differentiation of endometrial stromal cells (EnSCs) into specialized decidual cells. The decidua contributes to early nutrient exchange, production of cytokines, and growth factors as well as supports the development of new blood vessels, modulates extravillous trophoblast (EVT) invasion, and acts as a protective barrier against infections and maternal host immune responses.
Disturbances in the uterine microenvironment are associated with miscarriages and third-trimester perinatal morbidity and mortality caused by pre-eclampsia (PE) and intrauterine growth restriction, small-for-gestational age, pre-term birth, and stillbirth. It is increasingly evident that abnormal levels of inflammatory and growth/signaling factors produced in the decidua during early pregnancy play a decisive role in the deregulation of the local microenvironment leading to several disorders of pregnancy. Our research investigates how impaired cytoskeletal rearrangement and stiffness participates in the pathophysiology of pre-eclampsia.Evaluation of new point-of-care tools for use in pregnancy
Rapid and frequent screening of molecules is necessary for precise interventions in severe pathophysiological conditions. We are evaluating the use of point-of-care-ready bioanalytical platforms for screening of multiplexed-cytokines based on one-dimensional ion-sensitive field-effect transistors arrays (nanoISFETs) of silicon fabricated at wafer-scale via nanoimprint lithography in collaboration with RWTH, Aachen, Germany.GrantsPrincipal Applicant. Margarete von Wrangell-Habilitationsprogramm für Frauen. Funding Source: BMBF and EU Funding
Principal Investigator. InUtero; Stillbirth prediction. Funding Source: Wellcome Leap
Principal Applicant. Athene Grant for Women Scientists. Funding Source: Federal Ministry of Education and Research (BMBF)
Principal Applicant. Role of NFAT5 in the endometrium. Funding Source: Else Kröner-Fresenius Foundation
Principal Applicant. Placental organoids and COVID-19 infection. Funding Source: Ferring Pharmaceuticals
Honours & AwardsTravel Award, Paris - European Molecular Biology Laboratory meeting
Study Exchange Program Prize - Juntendo University School of Medicine
Citizenship Award - London
2023 - Lindau Nobel Laurate Meeting Attendee
2019 - Finalist for Maria Gräfin von Linden Prize
Congratulations to the 2025 Outstanding Achievement recipients
The Outstanding Achievement Award recognizes the remarkable accomplishments of our trainees in research aimed at improving the health and well-being of children and families. Generously funded by the BC Children’s Hospital Foundation, this program plays a pivotal role in acknowledging and nurturing excellence within our research community. Each year, awards are given to trainees whose research skills and analytical abilities demonstrate strong potential to contribute meaningfully to the scientific community.
