Matthew Smyth
MD
Investigator and Pediatric Gastroenterologist, BC Children's Hospital
Inflammatory Bowel Diseases
Amelia Kellar and Tessa George and Michael T Dolinger and Noa Krugliak Cleveland and David T Rubin and Jolle St-Pierre
DOI: 10.1093/ibd/izaf23811 / 2025
Inflammatory Bowel Diseases
Kayal, M. and Spencer, E.A. and Smyth, M. and Raffals, L. and Qazi, T. and Deepak, P. and Beniwal-Patel, P. and Chang, S. and Higgins, P. and Cross, R.K. and Anderson, C. and Long, M. and Herfarth, H.H. and Dubinsky, M.C. and Barnes, E.L.
DOI: 10.1093/ibd/izae164Digestive Diseases and Sciences
Smyth, M.J. and Dolinger, M.T. and Kellar, A. and Spencer, E.A. and Dubinsky, M.C.
DOI: 10.1007/s10620-025-09181-xJournal of the Canadian Association of Gastroenterology
Smyth, M. and Lunken, G. and Jacobson, K.
DOI: 10.1093/jcag/gwad058Journal of the Canadian Association of Gastroenterology
Wine, E. and Debruyn, J. and Crowley, E. and Griffiths, A.M. and Jeong, J. and Jacobson, K. and Lawrence, S. and Piper, H. and Smyth, M. and Tropini, C. and Vallance, B. and de Bruyn, J. and Huynh, H. and Carroll, M. and Isaac, D.M. and Armstrong, H. and El-Matary, W. and Grover, Z. and Bax, K. and Brill, H. and Dowhaniuk, J. and Prowse, K. and Sherlock, M. and Zachos, M. and Hart, L. and Popalis, C. and Griffths, A.M. and Muise, A. and Ricciuto, A. and Benchimol, E. and Jones, N. and Carman, N. and Church, P. and Walters, T. and Mulder, D. and Mack, D. and Stanisz, J. and Stintzi, A. and Pai, N. and Deslandres, C. and Breton, J. and Grzywacz, K. and Jantchou, P. and Chapuy, L. and Schneider, R. and Otley, A. and Burnett, D. and Critch, J. and Dinn, S.
DOI: 10.1093/jcag/gwae034The Journal of Pediatrics
Matthew Smyth and Justin Chan and Kathi Evans and Carlie Penner and Alam Lakhani and Theresa Newlove and Kevan Jacobson
DOI: 10.1016/j.jpeds.2021.07.03611 / 2021
Clinical Epidemiology
Justin M Chan and Matthew W Carroll and Matthew Smyth and Zachary Hamilton and Dewey Evans and Kimberlyn McGrail and Eric I Benchimol and Kevan Jacobson
DOI: 10.2147/clep.s29254602 / 2021
Data in Brief
Smyth, M. and Jacobson, K.
DOI: 10.1016/j.dib.2021.107599Journal of the Canadian Association of Gastroenterology
David O Prichard and Zachary Hamilton and Thomas Savage and Matthew Smyth and Carlie Penner and Alam Lakhani and Matthew W Carroll and Ahmed Al Sarkhy and Daniel A Lemberg and Robert Enns and Douglas Jamieson and Kevan Jacobson
DOI: 10.1093/jcag/gwz02809 / 2019
World Journal of Gastroenterology
Alice Jane Foster and Matthew Smyth and Alam Lakhani and Benjamin Jung and Rollin F Brant and Kevan Jacobson
DOI: 10.3748/wjg.v25.i10.126603 / 2019
Inflammatory Bowel Diseases
Julianna Cheng and Zachary Hamilton and Matthew Smyth and Collin Barker and David Israel and Kevan Jacobson
DOI: 10.1097/mib.000000000000121210 / 2017
Gastroenterology
David O. Prichard and Zachary Hamilton and Thomas Savage and Matthew Smyth and Carlie Penner and Alam Lakhani and Matthew Carroll and Ahmed A. Alsarkhy and Daniel Lemberg and Robert A. Enns and Robert J. Prosser and Daniel Jamieson and Kevan Jacobson
DOI: 10.1016/s0016-5085(17)32196-004 / 2017
Inflammatory Bowel Diseases
Matthew W. Carroll and Zachary Hamilton and Hira Gill and Jonathan Simkin and Matthew Smyth and Victor Espinosa and Brian Bressler and Kevan Jacobson
DOI: 10.1097/mib.000000000000065102 / 2016
Intestinal ultrasound (IUS) accurately detects intestinal inflammation in patients with inflammatory bowel disease (IBD). On ultrasound, inflamed bowel appears thickened (an increase in bowel wall thickness, BWT) and hyperemic (an increase in vascular flow within in the bowel wall, measured using doppler), and extra-luminal features are often present including inflammatory fat and lymphadenopathy. The transmural (ultrasound) features of normal bowel are well established in the adult population, with measurement thresholds that correlate well with colonoscopy findings. Colonoscopy is the gold standard assessment tool for IBD, and is the test used to guide therapy decision: however, with the exceptional accuracy of IUS for predicting colonoscopy, decisions are frequently made based on IUS alone. However, pediatric transmural findings differ significantly compared to adult norms, specifically in young children. There is a significant gap in our understanding of ultrasound findings in young patients: there is an urgent need to understand pediatric norms and establish pediatric-specific thresholds for macroscopic changes on colonoscopy. This study looks to definitively establish pediatric norms, and develop measurement thresholds for ultrasound that correlate to mild, moderate, and severe changes on colonoscopy. This will initially be looked at retrospectively, which will subsequently be used at the background for a prospective multi-centre study.
Advanced therapies in Inflammatory Bowel Disease (IBD) are rapidly expanding in number and immune pathways targeted. However, not all patients respond to a given therapy. Intestinal Ultrasound (IUS) offers a non-invasive way to assess for treatment response in patients with IBD, which can help guide dosing and therapy decisions to help maximize a patients chance of achieving disease remission. Historically, a patient will wait 12 months after a treatment is initiated before a re-assessment of their response is done by colonoscopy. However, IUS can detect changes in bowel inflammation within days of starting treatment. This study aims to look at transmural (ultrasound) changes after 3 months of therapy, and understand what factors predict disease remission at 1 year of therapy. Furthermore, in patients who do not achieve a transmural response after 3 months of therapy, we look to understand whether therapy optimization based on IUS improves the chance of remission on that therapy at 12 months.
This study will be conducted at BC Children’s Hospital, the IBD Centre of BC, and potentially 3-4 other sites across Canada/US.
2023–2024 - Advanced fellow, Inflammatory Bowel Disease, Icahn School of Medicine at Mount Sinai, New York
2023 - Laura Macrae Award, UBC Department of Pediatrics
2023 - Fellowship Research Award, UBC Department of Pediatrics
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