Overview

My research is primarily involved in the development, prevention and treatment of type 1 (insulin-dependent or juvenile-onset) diabetes. I am an investigator in several multicenter clinical trials involved in preventing type 1 diabetes.

I also maintain our Division's large website providing resources for families of children with diabetes and other endocrine disorders, and for the professionals caring for these patients.

Working with local and provincial resources, I have helped initiate an endocrine treatment program for transgender youth, and I am a Co-Investigator on a pan-Canadian study of these youth and their families (Trans Youth CAN!).

Publications

Une approche d'affirmation pour les soins aux jeunes transgenres et de diverses identités de genre
Paediatrics and Child Health (Canada)
Vandermorris, A. and Metzger, D.L.
DOI: 10.1093/pch/pxad046
2023

Measuring severe obesity in pediatrics: A cohort study
Research Square
Ball, G.D.C. and Sharma, A.K. and Moore, S.A. and Metzger, D.L. and Klein, D. and Morrison, K.M.
DOI: 10.21203/rs.3.rs-2715882/v1
2023

Measuring severe obesity in pediatrics using body mass index-derived metrics from the Centers for Disease Control and Prevention and World Health Organization: a secondary analysis of CANadian Pediatric Weight management Registry (CANPWR) data
European Journal of Pediatrics
Ball, G.D.C. and Sharma, A.K. and Moore, S.A. and Metzger, D.L. and Klein, D. and Morrison, K.M. and Buchholz, A. and Chanoine, J.-P. and Hamilton, J. and Ho, J. and Laberge, A.-M. and Legault, L. and Thabane, L. and Tremblay, M.S. and Zenlea, I.
DOI: 10.1007/s00431-023-05039-4
2023

An affirming approach to caring for transgender and gender-diverse youth
Paediatrics and Child Health (Canada)
Vandermorris, A. and Metzger, D.L.
DOI: 10.1093/pch/pxad045
2023

Targeted treatment of immune thrombocytopenia in CTLA-4 insufficiency: a case report
British Journal of Haematology
Lai, C.M.B. and Setiadi, A. and Barlas, A. and Kanani, A. and Pourshahnazari, P. and Leitch, H.A. and Metzger, D.L. and Merkeley, H. and Biggs, C.M.
DOI: 10.1111/bjh.17866
2022

Reply
Journal of Pediatrics
Bauer, G.R. and Lawson, M.L. and Metzger, D.L.
DOI: 10.1016/j.jpeds.2022.03.004
2022

Toward Building a Provincial Diabetes Registry of Children and Youth Living With Diabetes in British Columbia, Canada
Canadian Journal of Diabetes
Ayub, A. and Ng, C. and Portales-Casamar, E. and Metzger, D. and Amed, S.
DOI: 10.1016/j.jcjd.2021.11.006
2022

Endocrine treatment of transgender and gender-diverse people
British Columbia Medical Journal
Dahl, M. and Metzger, D.L.
2022

Gender-affirming care in British Columbia, Part 2
British Columbia Medical Journal
Knudson, G. and Findlay, B. and Metzger, D.L.
2022

Do Clinical Data from Transgender Adolescents Support the Phenomenon of “Rapid Onset Gender Dysphoria”?
Journal of Pediatrics
Bauer, G.R. and Lawson, M.L. and Metzger, D.L.
DOI: 10.1016/j.jpeds.2021.11.020
2022

Precocious puberty: A red flag for malignancy in childhood
British Columbia Medical Journal
D?alessandro, P.R. and Hamilton, J. and Khatchadourian, K. and Lunaczek-Motyka, E. and Schultz, K.R. and Metzger, D. and Deyell, R.J.
2021

Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk
Diabetologia
Nucci, A.M. and Virtanen, S.M. and Cuthbertson, D. and Ludvigsson, J. and Einberg, U. and Huot, C. and Castano, L. and Aschemeier, B. and Becker, D.J. and Knip, M. and Krischer, J.P. and Mandrup-Poulsen, T. and Arjas, E. and L{\"a}{\"a}r{\"a}, E. and Lernmark, ?. and Schmidt, B. and ?kerblom, H.K. and Hyytinen, M. and Koski, K. and Koski, M. and Pajakkala, E. and Salonen, M. and Shanker, L. and Bradley, B. and Dosch, H.-M. and Dupr{\'e}, J. and Fraser, W. and Lawson, M. and Mahon, J.L. and Sermer, M. and Taback, S.P. and Becker, D. and Franciscus, M. and Nucci, A. and Palmer, J. and Catteau, J. and Howard, N. and Crock, P. and Craig, M. and Clarson, C.L. and Bere, L. and Thompson, D. and Metzger, D. and Marshall, C. and Kwan, J. and Stephure, D.K. and Pacaud, D. and Schwarz, W. and Girgis, R. and Thompson, M. and Catte, D. and Lawson, M.L. and Bradley, B. and Daneman, D. and Sermer, M. and Martin, M.-J. and Morin, V. and Frenette, L. and Ferland, S. and Sanderson, S. and Heath, K. and Huot, C. and Gonthier, M. and Thibeault, M. and Legault, L. and Laforte, D. and Cummings, E.A. and Scott, K. and Bridger, T. and Crummell, C. and Houlden, R. and Breen, A. and Carson, G. and Kelly, S. and Sankaran, K. and Penner, M. and White, R.A. and King, N. and Popkin, J. and Robson, L. and Al Taji, E. and Mendlova, P. and Romanova, M. and Vavrinec, J. and Vosahlo, J. and Brazdova, L. and Venhacova, J. and Venhacova, P. and Cipra, A. and Tomsikova, Z. and Paterov{\'a}, P. and Gogelova, P. and Einberg, {\"U}. and Riikj{\"a}rv, M.-A. and Ormisson, A. and Tillmann, V. and Johansson, S. and Kleemola, P. and Parkkola, A. and J{\"a}rvenp{\"a}{\"a}, A.-L. and H{\"a}m{\"a}l{\"a}inen, A.-M. and Kiiveri, S. and Salonen, M. and Tenhola, S. and Salonen, P. and Jason, E. and Selvenius, J. and Siljander, H. and Ylitalo, S. and Paajanen, I. and Talvitie, T. and Lindstr{\"o}m, K. and Huopio, H. and Pesola, J. and Veijola, R. and Tapanainen, P. and Alar, A. and Popov, E. and Virransalo, R. and Nyk{\"a}nen, P. and Danne, T. and Kordonouri, O. and Krikovszky, D. and Mad{\'a}csy, L. and Khazrai, Y.M. and Maddaloni, E. and Pozzilli, P. and Mannu, C. and Songini, M. and de Beaufort, C. and Schierloh, U. and Bruining, J. and Bisschoff, M. and Basiak, A. and Wasikowa, R. and Ciechanowska, M. and Deja, G. and Jarosz-Chobot, P. and Szadkowska, A. and Cypryk, K. and Zawodniak-Szalapska, M. and Frutos, T.G. and Oyarzabal, M. and Serrano-R{\'i}os, M. and Mart{\'i}nez-Larrad, M.T. and Hawkins, F.G. and Arnau, D.R. and Konefal, M.S. and Hanas, R. and Lindblad, B. and Nilsson, N.-{\"O}. and Fors, H. and Nordwall, M. and Lindh, A. and Edenwall, H. and ?man, J. and Johansson, C. and Gadient, M. and Konrad, D. and Schoenle, E. and Becker, D. and Daftary, A. and Klein, M.B. and Gilmour, C. and Palmer, J. and Malone, P. and Tanner-Blasiar, M. and White, N. and Devaskar, U. and Horowitz, H. and Rogers, L. and Colon, R. and Frazer, T. and Torres, J. and Goland, R. and Greenberg, E. and Schachner, H. and Softness, B. and Ilonen, J. and Trucco, M. and Nichol, L. and Savilahti, E. and H{\"a}rk{\"o}nen, T. and Vaarala, O. and Luopaj{\"a}rvi, K. and Dosch, H.-M.
DOI: 10.1007/s00125-020-05358-3
2021

Prevalence of high blood pressure among Canadian Children: 2017 American Academy of Pediatrics guidelines with the Canadian Health Measures Survey
Paediatrics and Child Health (Canada)
Robinson, S.K. and Rodd, C.J. and Metzger, D.L. and Sharma, A.K.
DOI: 10.1093/pch/pxaa026
2021

Transgender youth referred to clinics for gender-affirming medical care in canada
Pediatrics
Bauer, G.R. and Pacaud, D. and Couch, R. and Metzger, D.L. and Gale, L. and Gotovac, S. and Mokashi, A. and Feder, S. and Raiche, J. and Speechley, K.N. and Newhook, J.T. and Ghosh, S. and Sansfacon, A.P. and Susset, F. and Lawson, M.L.
DOI: 10.1542/peds.2020-047266
2021

Isolated diastolic high blood pressure: a distinct clinical phenotype in US children
Pediatric Research
Alsaeed, H. and Metzger, D.L. and Blydt-Hansen, T.D. and Rodd, C. and Sharma, A.
DOI: 10.1038/s41390-021-01369-x
2021

Are there alternatives to over-the-counter diabetes-care glucose-gels for transitional neonatal hypoglycemia?
Paediatrics and Child Health (Canada)
Solimano, A. and Osiovich, H. and Kwan, E. and Metzger, D.L. and Everett, R.
DOI: 10.1093/pch/pxaa002
2021

Effects of Bisphosphonate Therapy on Bone Mineral Density in Boys with Duchenne Muscular Dystrophy.
Clinical medicine insights. Endocrinology and diabetes
Ronsley R and Islam N and Kang M and Nadel H and Reilly C and Metzger D and Selby K and Panagiotopoulos C
DOI: 10.1177/1179551420972400
PubMed: 33335437
12/2020

Fluid management in children with diabetic ketoacidosis.
Canadian family physician Medecin de famille canadien
McGregor S and Metzger DL and Amed S and Goldman RD
PubMed: 33208421
11/2020

Fluid management in children with diabetic ketoacidosis,Prise en charge des liquides chez les enfants atteints d’acidocétose diabétique
Canadian Family Physician
McGregor, S. and Metzger, D.L. and Amed, S. and Goldman, R.D.
2020

Is Age a Risk Factor for Cerebral Edema in Children With Diabetic Ketoacidosis? A Literature Review
Canadian Journal of Diabetes
Glackin, S. and Metzger, D. and Hanas, R. and Chanoine, J.-P.
DOI: 10.1016/j.jcjd.2019.04.013
2020

Growth Hormone Supplementation and Psychosocial Functioning to Adult Height in Turner Syndrome: A Questionnaire Study of Participants in the Canadian Randomized Trial.
Frontiers in endocrinology
Rovet JF and Van Vliet G
DOI: 10.3389/fendo.2019.00125
PubMed: 30930850
03/2019

Prevalence and Severity of High Blood Pressure Among Children Based on the 2017 American Academy of Pediatrics Guidelines
JAMA Pediatrics
Atul K. Sharma and Daniel L. Metzger and Celia J. Rodd
DOI: 10.1001/jamapediatrics.2018.0223
06/2018

Glucose control and autonomic response during acute stress in youth with type 1 diabetes: A pilot study.
Pediatric diabetes
Guan L and Metzger DL and Lavoie PM and Collet JP
DOI: 10.1111/pedi.12680
PubMed: 29654713
05/2018

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.
JAMA
Writing Group for the TRIGR Study Group and Knip M and Åkerblom HK and Al Taji E and Becker D and Bruining J and Castano L and Danne T and de Beaufort C and Dosch HM and Dupre J and Wasikowa R
DOI: 10.1001/jama.2017.19826
PubMed: 29297078
01/2018

Adherence to a pediatric diabetic ketoacidosis protocol in children presenting to a tertiary care hospital
Pediatric Diabetes
Ronsley, R. and Islam, N. and Ronsley, C. and Metzger, D.L. and Panagiotopoulos, C.
DOI: 10.1111/pedi.12556
2018

WHO height charts can be safely substituted when calculating BP Z-scores in a North American clinic setting
Paediatrics and Child Health (Canada)
Rodd, C.J. and Metzger, D.L. and Sharma, A.K.
DOI: 10.1093/pch/pxx185
2018

Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial
Maternal & Child Nutrition
DOI: 10.1111/mcn.12354
07/2017

Hypogonadotropic Hypogonadism in Males with Glycogen Storage Disease Type 1.
JIMD reports
DOI: 10.1007/8904_2016_38
PubMed: 28160246
02/2017

Re: Young adult patients with diabetes presenting to a university health clinic with depression and anxiety
British Columbia Medical Journal
Metzger, D.L.
2017

Exome Sequencing and the Management of Neurometabolic Disorders.
The New England journal of medicine
Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drögemöller BI and Abdelsayed M and Alfadhel M and van Karnebeek CD
DOI: 10.1056/nejmoa1515792
PubMed: 27276562
05/2016

Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects.
Endocrine-related cancer
Daly AF and Yuan B and Fina F and Caberg JH and Trivellin G and Rostomyan L and de Herder WW and Naves LA and Metzger D and Cuny T and Rabl W and Shah N and Jaffrain-Rea ML and Zatelli MC and Beckers A
DOI: 10.1530/erc-16-0082
PubMed: 26935837
03/2016

Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects
Endocrine-Related Cancer
Daly, A.F. and Yuan, B. and Fina, F. and Caberg, J.-H. and Trivellin, G. and Rostomyan, L. and De Herder, W.W. and Naves, L.A. and Metzger, D. and Cuny, T. and Rabl, W. and Shah, N. and Jaffrain-Rea, M.-L. and Chiara Zatelli, M. and Faucz, F.R. and Castermans, E. and Nanni-Metellus, I. and Lodish, M. and Muhammad, A. and Palmeira, L. and Potorac, I. and Mantovani, G. and Neggers, S.J. and Klein, M. and Barlier, A. and Liu, P. and Ouafik, L. and Bours, V. and Lupski, J.R. and Stratakis, C.A. and Beckers, A.
DOI: 10.1530/ERC-16-0082
2016

Exome sequencing and the management of neurometabolic disorders
New England Journal of Medicine
Tarailo-Graovac, M. and Shyr, C. and Ross, C.J. and Horvath, G.A. and Salvarinova, R. and Ye, X.C. and Zhang, L.-H. and Bhavsar, A.P. and Lee, J.J.Y. and Drögemöller, B.I. and Abdelsayed, M. and Alfadhel, M. and Armstrong, L. and Baumgartner, M.R. and Burda, P. and Connolly, M.B. and Cameron, J. and Demos, M. and Dewan, T. and Dionne, J. and Evans, A.M. and Friedman, J.M. and Garber, I. and Lewis, S. and Ling, J. and Mandal, R. and Mattman, A. and McKinnon, M. and Michoulas, A. and Metzger, D. and Ogunbayo, O.A. and Rakic, B. and Rozmus, J. and Ruben, P. and Sayson, B. and Santra, S. and Schultz, K.R. and Selby, K. and Shekel, P. and Sirrs, S. and Skrypnyk, C. and Superti-Furga, A. and Turvey, S.E. and Van Allen, M.I. and Wishart, D. and Wu, J. and Wu, J. and Zafeiriou, D. and Kluijtmans, L. and Wevers, R.A. and Eydoux, P. and Lehman, A.M. and Vallance, H. and Stockler-Ipsiroglu, S. and Sinclair, G. and Wasserman, W.W. and Van Karnebeek, C.D.
DOI: 10.1056/NEJMoa1515792
2016

LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: association with cardio-metabolic risks.
Pediatric research
DOI: 10.1038/pr.2015.160
PubMed: 26331767
12/2015

Use of growth charts in Canada: A National Canadian Paediatric Surveillance Program survey.
Paediatrics & child health
DOI: 10.1093/pch/20.4.185
PubMed: 26038634
05/2015

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Nature genetics
Onengut-Gumuscu S and Chen WM and Burren O and Cooper NJ and Quinlan AR and Mychaleckyj JC and Farber E and Bonnie JK and Szpak M and Schofield E and Achuthan P and Guo H and Rich SS
DOI: 10.1038/ng.3245
PubMed: 25751624
03/2015

X-linked acrogigantism syndrome: clinical profile and therapeutic responses.
Endocrine-related cancer
Beckers A and Lodish MB and Trivellin G and Rostomyan L and Lee M and Faucz FR and Yuan B and Choong CS and Caberg JH and Verrua E and Naves LA and Cheetham TD and Young J and Lysy PA and Stratakis CA
DOI: 10.1530/erc-15-0038
PubMed: 25712922
02/2015

X-linked acrogigantism syndrome: Clinical profile and therapeutic responses
Endocrine-Related Cancer
Beckers, A. and Lodish, M.B. and Trivellin, G. and Rostomyan, L. and Lee, M. and Faucz, F.R. and Yuan, B. and Choong, C.S. and Caberg, J.-H. and Verrua, E. and Naves, L.A. and Cheetham, T.D. and Young, J. and Lysy, P.A. and Petrossians, P. and Cotterill, A. and Shah, N.S. and Metzger, D. and Castermans, E. and Ambrosio, M.R. and Villa, C. and Strebkova, N. and Mazerkina, N. and Gaillard, S. and Barra, G.B. and Casulari, L.A. and Neggers, S.J. and Salvatori, R. and Jaffrain-Rea, M.-L. and Zacharin, M. and Santamaria, B.L. and Zacharieva, S. and Lim, E.M. and Mantovani, G. and Zatelli, M.C. and Collins, M.T. and Bonneville, J.-F. and Quezado, M. and Chittiboina, P. and Oldfield, E.H. and Bours, V. and Liu, P. and De Herder, W.W. and Pellegata, N. and Lupski, J.R. and Daly, A.F. and Stratakis, C.A.
DOI: 10.1530/ERC-15-0038
2015

Managing type 1 diabetes in school: Recommendations for policy and practice
Paediatrics and Child Health (Canada)
Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.
DOI: 10.1093/pch/20.1.35
2015

Managing type 1 diabetes in school: Recommendations for policy and practice,Prise en charge du diabète de type 1 à l'école : Recommandations de politiques et de pratiques
Paediatrics and Child Health (Canada)
Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.
DOI: 10.1093/pch/20.1.40
2015

Managing type 1 diabetes in school: Recommendations for policy and practice.
Paediatrics & child health
PubMed: 25722642
2015

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
The New England journal of medicine
Trivellin G and Daly AF and Faucz FR and Yuan B and Rostomyan L and Larco DO and Schernthaner-Reiter MH and Szarek E and Leal LF and Caberg JH and Castermans E and Villa C and Stratakis CA
DOI: 10.1056/nejmoa1408028
PubMed: 25470569
12/2014

Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: phenotypic and molecular characterization.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2014-1029
PubMed: 24823460
09/2014

Hydrolyzed infant formula and early ß-cell autoimmunity: a randomized clinical trial.
JAMA
DOI: 10.1001/jama.2014.5610
PubMed: 24915259
06/2014

Clinical management of youth with gender dysphoria in Vancouver.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2013.10.068
PubMed: 24315505
04/2014

Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada.
Healthcare Policy
PubMed: 24726076
02/2014

B7-H4 expression in normal and diseased human islet ß cells.
Pancreas
DOI: 10.1097/mpa.0b013e31829695d2
PubMed: 24326367
01/2014

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation
New England Journal of Medicine
Trivellin, G. and Daly, A.F. and Faucz, F.R. and Yuan, B. and Rostomyan, L. and Larco, D.O. and Schernthaner-Reiter, M.H. and Szarek, E. and Leal, L.F. and Caberg, J.-H. and Castermans, E. and Villa, C. and Dimopoulos, A. and Chittiboina, P. and Xekouki, P. and Shah, N. and Metzger, D. and Lysy, P.A. and Ferrante, E. and Strebkova, N. and Mazerkina, N. and Zatelli, M.C. and Lodish, M. and Horvath, A. and Bertollo De Alexandre, R. and Manning, A.D. and Levy, I. and Keil, M.F. and De La Luz Sierra, M. and Palmeira, L. and Coppieters, W. and Georges, M. and Naves, L.A. and Jamar, M. and Bours, V. and Wu, T.J. and Choong, C.S. and Bertherat, J. and Chanson, P. and Kamenicky, P. and Farrell, W.E. and Barlier, A. and Quezado, M. and Bjelobaba, I. and Stojilkovic, S.S. and Wess, J. and Costanzi, S. and Liu, P. and Lupski, J.R. and Beckers, A. and Stratakis, C.A.
DOI: 10.1056/NEJMoa1408028
2014

Extending World Health Organization weight-for-age reference curves to older children
BMC Pediatrics
Rodd, C. and Metzger, D.L. and Sharma, A. and Cummings, E. and Chanoine, J.-P. and Lawrence, S. and Palmert, M.
DOI: 10.1186/1471-2431-14-32
2014

Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine
PLoS Genetics
Holik, A.Z. and Young, M. and Krzystyniak, J. and Williams, G.T. and Metzger, D. and Shorning, B.Y. and Clarke, A.R.
DOI: 10.1371/journal.pgen.1004453
2014

Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada
Healthcare Policy
Hasan, H. and Howard, F. and Morgan, S.G. and Metzger, D.L. and Lo, A.C. and Goddard, K. and Gill, S. and Johnson, M.
DOI: 10.12927/hcpol.2014.23728
2014

B7-H4 expression in normal and diseased human islet ß Cells
Pancreas
Cheung, S.S.C. and Ou, D. and Metzger, D.L. and Meloche, M. and Ao, Z. and Ng, S.S.W. and Owen, D. and Warnock, G.L.
DOI: 10.1097/MPA.0b013e31829695d2
2014

Canadian endocrinologists' views on growth hormone replacement therapy in adult survivors of pediatric brain tumors following achievement of final height
British Columbia Medical Journal
Hasan, H. and Fuchsia Howard, A. and Metzger, D.L. and Gill, S. and Johnson, M. and Lo, A.C. and Goddard, K.
2014

Canadian endocrinologists’ views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height
BC Medical Journal
2014

Canadian Pediatric Endocrine Group extension to WHO growth charts: Why bother?
Paediatrics & child health
PubMed: 24421695
06/2013

Case 2: Pimples in prepuberty: A five-year-old with an unusual cause of facial comedones.
Paediatrics & child health
DOI: 10.1093/pch/18.2.91a
PubMed: 24421664
02/2013

Endogenous expression of B7-H4 improves long-term murine islet allograft survival.
Transplantation
DOI: 10.1097/tp.0b013e318277229d
PubMed: 23192157
01/2013

Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty.
Hormone research in paediatrics
DOI: 10.1159/000351028
PubMed: 23859950
2013

Canadian Pediatric Endocrine Group extension to WHO growth charts: Why bother?
Paediatrics and Child Health (Canada)
Lawrence, S. and Cummings, E. and Chanoine, J.-P. and Metzger, D.L. and Palmert, M. and Sharma, A. and Rodd, C.
DOI: 10.1093/pch/18.6.295
PubMed: 24421695
2013

Endogenous expression of B7-H4 improves long-term murine islet allograft survival
Transplantation
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Lee, I.-F. and Akhoundsadegh, N. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Warnock, G.L.
DOI: 10.1097/TP.0b013e318277229d
2013

When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR).
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2012-1264
PubMed: 22745237
09/2012

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry
Nature Genetics
Hunt, K.A. and Smyth, D.J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmad, T. and Anand, V. and Barrett, J.C. and Bhaw-Rosun, L. and Bockett, N.A. and Brand, O.J. and Brouwer, E. and Concannon, P. and Cooper, J.D. and Dias, K.-R.M. and Van Diemen, C.C. and Dubois, P.C. and Edkins, S. and F{\"o}lster-Holst, R. and Fransen, K. and Glass, D.N. and Heap, G.A.R. and Hofmann, S. and Huizinga, T.W.J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Marrosu, M.G. and Mathew, C.G. and Mein, C.A. and M{\"u}ller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N.J. and Posthumus, M.D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M.J. and Sudman, M. and Thompson, S.D. and Toes, R. and Trynka, G. and Vyse, T.J. and Walker, N.M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S.S. and Todd, J.A. and Van Heel, D.A. and Baskerville, T. and Bautista, N. and Bhatia, E. and Bhatia, V. and Hasan, K.B. and Bonnici, F. and Brodnicki, T. and Browning, B. and Cameron, F. and Chaichanwatanakul, K. and Cheung, P.T. and Colman, P. and Cotterill, A. and Couper, J. and Crock, P. and Cutfield, R. and Davis, T. and Dixon, P. and Donaghue, K. and Dowling, K. and Drury, P. and Dye, S. and Gellert, S. and Ghani, R.A. and Greer, R. and Han, X. and Harrison, L. and Homatopoulos, N. and Ji, L. and Jones, T. and Yin, L.K. and Kamaruddin, N.A. and Kanga, U. and Kanungo, A. and Kaur, G. and Kek, B. and Knowles, S. and Krebs, J. and Kumar, N. and Lee, Y.-J. and Li, X. and Liktimaskul, S. and Lloyd, M. and Loth, A. and Louey, A. and Mehra, N. and Merriman, T. and Min, L. and Morahan, G. and Moses, R. and Mraz, G. and Murphy, R. and Nicholson, I. and Panelo, A. and Poh, P. and Price, G. and Ratnam, N. and Sanjeevi, C. and Sedimbi, S. and Shen, S. and Ying, G.S. and Tait, B. and Tandon, N. and Thomas, A. and Varney, M. and Weerakulwattana, P. and Willis, J. and Akwo, E.A. and Albret, L. and Ampudia-Blasco, F. and Argente, J. and Avbelj, M. and Babadjanova, G. and Badenhoop, K. and Battelino, T. and Beilhack, G. and Bergholdt, R. and Bingley, P. and Boehm, B. and Bolidson, J. and Brismar, K. and Brorsson, C. and Carlson, J. and Castano, L. and Chandler, K. and Cherubini, V. and Cinek, O. and Cipponeri, E. and Collado, R.C. and de Leiva, A. and Dzivite, I. and Fagulha, A. and Balcells, M.F. and Cuartero, B.G. and Lacalle, C.G. and Guja, C. and Guti{\'e}rrez, P. and Hamou, A. and Hatziagelaki, E. and Heath, S. and Heilman, K. and Helmberg, W. and Hermon, O. and Hernandez, M. and Holzheu, I. and Hosszufalusi, N. and Ilonen, J. and Ionescu-Tirgoviste, C. and Johannesen, J. and Julier, C. and Kahles, H. and Kinalska, I. and Knip, M. and Kockum, I. and Kojo, E. and Kordonouri, O. and Kretowski, A. and Krikovszky, D. and Kurkhaus, A. and Kuzmicki, M. and Lavant, E. and Long, A. and Ludvigsson, J. and Madacsy, L. and Maliszewska, K. and Marga, M. and Martinez, M.P. and Mauricio, D. and Mazurkievicz, G. and Nerup, J. and Norkus, A. and Mogollon, F.J.N. and Okruszko, A. and Pettinari, C. and Phillip, M. and Pirags, V. and Pociot, F. and Pozzilli, P. and Racasan, R. and Raile, K. and Rappner, R. and Troyano, M.J.R. and Roep, B.O. and Rokni, S. and Rosinger, S. and Rubio-Cabezas, O. and Ruckgaber, C. and Satman, I. and Schober, E. and Seufert, J. and Sing, R. and Skrha, J. and Sobngwi, E. and Somerville, M. and Spinas, G. and Sumnik, Z. and Tillmann, V. and Undlien, D. and Urbanavicius, V. and Van der Auwera, B. and Miguel, F.V.S. and Vazeo-Gerasimidi, A. and Velickiene, D. and W{\"a}gner, A. and Walter, M. and Williams, A. and Ziegler, A. and Agleham, M. and Aldrich, A. and Alemzadeh, R. and Alper, C. and Aly, T. and Anastassiou, D. and Arora, S. and Austin, A. and Becker, D. and Benoist, C. and Berka, N. and Bhatia, S. and Bonella, P. and Bottini, N. and Boyle, S. and Braden, J. and Brady, B. and Brickman, W. and Christensen, R. and Couch, R. and Counts, D. and Crandall, J. and Daniels, M. and Dolan, L. and Donaldson, D. and Doria, A. and Eisenbarth, G. and Elder, J. and El-Hajj, R. and Erlich, H. and Fain, P. and Fear, A.L. and Ferry, R. and Fiallo-Scharer, R. and Geraghty, D. and Ghosh, S. and Gitelman, S. and Godwin, M. and Goland, R. and Goodman, N. and Goodwin, G. and Gravely, J. and Greenbaum, C. and Gudgeon, C. and Gunville, F. and Hagopian, W. and Hakonarson, H. and Hansen, J. and Harrington, K. and Hassing, J. and Hilliker, W. and Hoffman, R. and Hulbert, E. and Izquierdo, R. and Jospe, N. and Kaiserman, K. and Kaufman, F. and Kim, S. and Kloos, E. and Kosoy, R. and Lane, J. and Lane, J. and Lawrence, J. and Levetan, C. and Levin, P. and Lipton, R. and Lonsdale, J. and Magnuson, V. and Marks, J. and Mayer-Davis, B. and McEvoy, R. and McIndoe, R. and Merkle, L. and Metzger, D. and Miao, D. and Mickelson, E. and Moonsamy, P. and Moore, W. and Moran, A. and Noble, J. and Olsem, G. and Orban, T. and Orlowski, C. and Paterson, A. and Pietropaolo, M. and Pihoker, C. and Polychronakos, C. and Post, J. and Postellon, D. and Pugliese, A. and Qu, H.Q. and Quattrin, T. and Rappaport, M. and Raskin, P. and Risbeck, H. and Rodriguez, H. and Rodriguez, L. and Rogers, M. and Rubalcava, L. and Russell, B. and Schatz, D. and Scott, C. and She, J.-X. and Shilling, H. and Shulman, D. and Soyka, L. and Speiser, P. and Starkman, H. and Steck, A. and Stender, S. and Stratton, L. and Sur, D. and Taback, S. and Thrailkill, K. and Toth, E. and Trymbiski, P. and Tsalikian, E. and Vertachnik, K. and Wahlen, J. and Wang, X. and Weber, S. and Wherrett, D. and Willi, S. and Wilson, D. and Youkey, J. and Young, N. and Yu, L. and Zhao, L.P. and Zimmerman, D. and Adlem, E. and Allen, J. and Brown, J. and Burren, O. and Clarke, P. and Clayton, D. and Coleman, G. and Davison, L. and Downes, K. and Duley, S. and Dunger, D. and Esposito, L. and Everett, V. and Field, S. and Hafler, J. and Hardy, M. and Harrison, D. and Harrison, I. and Hawkins, S. and Healy, B. and Hood, S. and Howell, S. and Howson, J. and Maisuria, M. and Meadows, W. and Nezhenstsev, S. and Ovington, N. and Plagnol, V. and Rainbow, D. and Rainbow, K. and Raj, S. and Schuilenburg, H. and Simpson, A. and Smink, L. and Stevens, H. and Taylor, N. and Tuomilehto, J. and Wicker, L. and Widmer, B. and Wilson, M. and Withers, H. and Yang, J. and Brown, M. and Chen, W.-M. and Crews, A. and Griffin, J. and Hall, M. and Harnish, T. and Hepler, J. and Hilner, J. and King, N. and Lohman, K. and Lu, L. and Mychaleckyj, J. and Nail, J. and Perdue, L. and Pierce, J. and Reboussin, D. and Rushing, S. and Sale, M. and Sides, E. and Snively, B. and Teuschler, H. and Theil, G. and Wagenknecht, L. and Williams, D. and Akolkar, B. and McKeon, C. and Nierras, C. and Thomson, E. and Altshuler, D. and Au, K. and Bain, S. and Barcellos, L. and Barral, S. and Becker, T. and Briggs, F. and Bronson, P. and Daly, M. and de Bakker, P. and Devlin, B. and Eike, M.C. and Field, L. and Gabriel, S. and Garge, N. and Gaudieri, S. and Goldstein, B. and Gorodezky, C. and Hamon, S. and He, C. and Humphreys, K. and James, I. and Lathrop, M. and Lie, B.A. and Li, D. and Mack, S. and McGinnis, R. and McKinnon, E. and McLaren, W. and Nolan, D. and Olsson, M. and Ott, J. and Owerbach, D. and Patterson, C. and Podolsky, R. and Ramsay, P. and Rangantah, V. and Risch, N. and Ronningen, S. and Shao, X. and Single, R. and Steffes, M. and Thomson, G. and Valdes, A.M. and Vandiedonck, C. and Whittaker, P. and Zhang, Q. and Anderson, C. and Drummond, H.E. and Edwards, C. and Harrison, K.L. and Henderson, P. and Lees, C. and Mathew, C.G. and Mowat, C. and Newman, W. and Nimmo, E.R. and Phillips, A. and Russell, R. and Sanderson, J. and Wilson, D.C. and Zhang, H. and Brown, M.A. and Burton, P.R. and Caulfield, M.J. and Craddock, N. and Compston, A. and Duncanson, A. and Hall, A.S. and Hattersley, A.T. and Hill, A.V.S. and Hurles, M. and Kwiatkowski, D.P. and McCarthy, M. and Pembrey, M. and Rahman, N. and Samani, N.J. and Satsangi, J. and Stratton, M.R. and Worthington, J. and Donnelly, P.
DOI: 10.1038/ng.1037
2012

Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival
Islets
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Lee, I.-F. and Akhoundsadegh, N. and Chen, C.L. and Ou, D. and Ao, Z. and Verchere, C.B. and Warnock, G.L.
DOI: 10.4161/isl.21239
2012

Generation of transplantable beta cells for patient-specific cell therapy
International Journal of Endocrinology
Wang, X. and Metzger, D.L. and Meloche, M. and Hao, J. and Ao, Z. and Warnock, G.L.
DOI: 10.1155/2012/414812
2012

B7-H4 induces donor-specific tolerance in mouse islet allografts
Cell Transplantation
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Ao, Z. and Bruce Verchere, C. and Chen, L. and Ou, D. and Warnock, G.L.
DOI: 10.3727/096368911X582750
2012

B7-H4 treatment of t cells inhibits erk, jnk, p38, and akt activation
PLoS ONE
Wang, X. and Hao, J. and Metzger, D.L. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Mui, A. and Warnock, G.L.
DOI: 10.1371/journal.pone.0028232
2012

B7-H4 induces donor-specific tolerance in mouse islet allografts.
Cell transplantation
DOI: 10.3727/096368912x633815
PubMed: 21929869
2012

Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.
Diabetes
DOI: 10.2337/db11-0375
PubMed: 21984581
12/2011

Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome.
Pediatric radiology
DOI: 10.1007/s00247-011-2109-0
PubMed: 21567141
10/2011

Validation of diabetes case definitions using administrative claims data.
Diabetic medicine : a journal of the British Diabetic Association
DOI: 10.1111/j.1464-5491.2011.03238.x
PubMed: 21392063
04/2011

B7-H4 Pathway in Islet Transplantation and ß-Cell Replacement Therapies.
Journal of transplantation
DOI: 10.1155/2011/418902
PubMed: 22028949
2011

Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).
Clinical trials (London, England)
Hilner JE and Perdue LH and Sides EG and Pierce JJ and Wägner AM and Aldrich A and Loth A and Albret L and Wagenknecht LE and Nierras C and Akolkar B and T1DGC
DOI: 10.1177/1740774510373497
PubMed: 20603248
07/2010

Methylation profiling in individuals with Russell-Silver syndrome.
American journal of medical genetics. Part A
DOI: 10.1002/ajmg.a.33204
PubMed: 20082469
02/2010

Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol
BC Medical Journal
2010

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Nature Genetics
DOI: 10.1038/ng.381
06/2009

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.
Transplantation
DOI: 10.1097/tp.0b013e318195e5fa
PubMed: 19307783
02/2009

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse
Genesis
Wendling, O. and Bornert, J.-M. and Chambon, P. and Metzger, D.
DOI: 10.1002/dvg.20448
2009

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival
Transplantation
Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Ao, Z. and Verchere, C.B. and Chen, L. and Ou, D. and Warnock, G.L.
DOI: 10.1097/TP.0b013e318195e5fa
2009

Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
DOI: 10.1093/ndt/gfn386
PubMed: 18622023
12/2008

The TRIGR Trial: Testing the Potential Link between Weaning Diet and Type 1 Diabetes
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry
DOI: 10.2174/187152207780832315
06/2007

Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR)
Pediatric Diabetes
DOI: 10.1111/j.1399-5448.2007.00239.x
06/2007

Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure.
American journal of medical genetics. Part A
DOI: 10.1002/ajmg.a.31679
PubMed: 17431892
05/2007

Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults.
Journal of the American Society of Nephrology : JASN
DOI: 10.1681/asn.2005111188
PubMed: 16611713
05/2006

Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0600962103
PubMed: 16606836
04/2006

Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.
Cell transplantation
DOI: 10.3727/000000006783981837
PubMed: 28871868
2006

Autosomal dominant pseudohypoaldosteronism type 1: Mechanisms, evidence for neonatal lethality, and phenotypic expression in adults
Journal of the American Society of Nephrology
Geller, D.S. and Zhang, J. and Zennaro, M.-C. and Vallo-Boado, A. and Rodriguez-Soriano, J. and Furu, L. and Haws, R. and Metzger, D. and Botelho, B. and Karaviti, L. and Haqq, A.M. and Corey, H. and Janssens, S. and Corvol, P. and Lifton, R.P.
DOI: 10.1681/ASN.2005111188
2006

Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia.
Journal of the American Society of Nephrology : JASN
DOI: 10.1681/asn.2004110989
PubMed: 16107578
10/2005

Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human beta cells by Fas-associated death domain and nuclear factor kappaB.
Human immunology
DOI: 10.1016/j.humimm.2005.03.009
PubMed: 16112027
07/2005

Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2005-0572
PubMed: 15870119
07/2005

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.
Diabetes care
DOI: 10.2337/diacare.28.5.1068
PubMed: 15855569
05/2005

Tumor necrosis factor-related apoptosis-inducing ligand and CD56 expression in patients with type 1 diabetes mellitus.
Pancreas
DOI: 10.1097/01.mpa.0000148515.77497.4b
PubMed: 15714132
03/2005

Oculorespiratory syndrome after influenza immunization in children.
The Pediatric infectious disease journal
DOI: 10.1097/01.inf.0000148924.89558.d5
PubMed: 15665712
01/2005

Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic ß cells by Bcl-2 and X-linked inhibitor of apoptosis
Human Immunology
Ou, D. and Wang, X. and Metzger, D.L. and James, R.F.L. and Pozzilli, P. and Plesner, A. and Korneluk, R.G. and Verchere, C.B. and Tingle, A.J.
DOI: 10.1016/j.humimm.2004.12.002
2005

Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia
Journal of the American Society of Nephrology
Schlingmann, K.P. and Sassen, M.C. and Weber, S. and Pechmann, U. and Kusch, K. and Pelken, L. and Lotan, D. and Syrrou, M. and Prebble, J.J. and Cole, D.E.C. and Metzger, D.L. and Rahman, S. and Tajima, T. and Shu, S.-G. and Waldegger, S. and Seyberth, H.W. and Konrad, M.
DOI: 10.1681/ASN.2004110989
2005

Long on QT and low on calcium.
Cardiology in the young
DOI: 10.1017/s1047951104006134
PubMed: 15680004
12/2004

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY).
Clinical and investigative medicine. Medecine clinique et experimentale
PubMed: 15305805
06/2004

Addison’s disease in a child with systemic lupus erythematosus
Pediatric Rheumatology Online Journal
2004

Long on QT and low on calcium
Cardiology in the Young
Bradley, T.J. and Metzger, D.L. and Sanatani, S.
DOI: 10.1017/S1047951104006134
2004

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY)
Clinical and Investigative Medicine
McKinney, J.L. and Cao, H. and Robinson, J.F. and Metzger, D.L. and Cummings, E. and Riddell, D.C. and Sanderson, S.R. and Pacaud, D. and Ho, J. and Hegele, R.A.
2004

Current approaches to the prevention of type 1 diabetes
British Columbia Medical Journal
Metzger, D.L.
2004

Current approaches to the prevention of type 1 diabetes
BC Medical Journal
2004

Telephone contact by a diabetes nurse educator improves hemoglobin A1c in adolescents with poorly controlled type 1 diabetes: a randomized controlled trial
Canadian Journal of Diabetes
2003

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis
Biology of Reproduction
Weber, P. and Schuler, M. and Gérard, C. and Mark, M. and Metzger, D. and Chambon, P.
DOI: 10.1095/biolreprod.102.005801
2003

Weekly Telephone Contact by a Diabetes Educator in Adolescents with Type 1 Diabetes
Canadian Journal of Diabetes
Panagiotopoulos, C. and Preston, J.M. and Stewart, L.L. and Metzger, D.L. and Chanoine, J.-P.
2003

GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY).
Human mutation
DOI: 10.1002/humu.9090
PubMed: 12442280
12/2002

TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction.
Diabetologia
DOI: 10.1007/s00125-002-0926-2
PubMed: 12488957
12/2002

Effects of insulin in relatives of patients with type 1 diabetes mellitus.
The New England journal of medicine
DOI: 10.1056/nejmoa012350
PubMed: 12037147
05/2002

beta-cell antigen-specific CD56(+) NKT cells from type 1 diabetic patients: autoaggressive effector T cells damage human CD56(+) beta cells by HLA-restricted and non-HLA-restricted pathways.
Human immunology
DOI: 10.1016/s0198-8859(02)00372-5
PubMed: 12039407
04/2002

ß-cell antigen-specific CD56+ NKT cells from type 1 diabetic patients: Autoaggressive effector T cells damage human CD56+ ß cells by HLA-restricted and non-HLA-restricted pathways
Human Immunology
Ou, D. and Metzger, D.L. and Wang, X. and Pozzilli, P. and Tingle, A.J.
DOI: 10.1016/S0198-8859(02)00372-5
2002

Nine novel mutations in NR0B1 (DAX1) causing adrenal hypoplasia congenita.
Human mutation
DOI: 10.1002/humu.1236
PubMed: 11748852
12/2001

Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.86.11.5433
PubMed: 11701718
11/2001

High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
DOI: 10.1155/2001/640796
PubMed: 11381296
05/2001

Spectrum of mutations of the AAAS gene in allgrove syndrome: Lack of mutations in six kindreds with isolated resistance to corticotropin
Journal of Clinical Endocrinology and Metabolism
Sandrini, F. and Farmakidis, C. and Kirschner, L.S. and Wu, S.-M. and Tullio-Pelet, A. and Lyonnet, S. and Metzger, D.L. and Bourdony, C.J. and Tiosano, D. and Chan, W.-Y. and Stratakis, C.A.
DOI: 10.1210/jcem.86.11.8037
2001

Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie
DOI: 10.1155/2000/172914
PubMed: 11125180
12/2000

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus.
Diabetologia
DOI: 10.1007/s001250051373
PubMed: 10907121
06/2000

Erratum: Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issue (Genetics in Medicine (1999))
Genetics in Medicine
Travitz, J. and Metzger, D.
2000

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus
Diabetologia
Ou, D. and Mitchell, L.A. and Metzger, D.L. and Gillam, S. and Tingle, A.J.
2000

CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.
Human immunology
DOI: 10.1016/s0198-8859(99)00037-3
PubMed: 10439311
08/1999

Sex-Steroid—Hormone Modulation of the Somatotropic Axis During Normal Male Puberty
Sex-Steroid Interactions with Growth Hormone
Daniel L. Metzger and James R. Kerrigan
DOI: 10.1007/978-1-4612-1546-2_4
1999

CD4+ and CD8+ T-cell clones from congenital Rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes: Implications for HLA class I and II allelic linkage to disease susceptibility
Human Immunology
Ou, D. and Jonsen, L.A. and Metzger, D.L. and Tingle, A.J.
DOI: 10.1016/S0198-8859(99)00037-3
1999

Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor a
Molecular and Cellular Biology
Endoh, H. and Maruyama, K. and Masuhiro, Y. and Kobayashi, Y. and Goto, M. and Tai, H. and Yanagisawa, J. and Metzger, D. and Hashimoto, S. and Kato, S.
DOI: 10.1128/mcb.19.8.5363
1999

Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issues.
Genetics in medicine : official journal of the American College of Medical Genetics
PubMed: 11256677
1999

A provincial protocol for the treatment of diabetic ketoacidosis in children
BC Medical Journal
1998

Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.82.10.4317
PubMed: 9329378
10/1997

The short-term infusion of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.82.2.3782
PubMed: 9024279
02/1997

The short-term infusion of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men
Journal of Clinical Endocrinology and Metabolism
Metzger, D.L. and Kerrigan, J.R. and Rogol, A.D.
DOI: 10.1210/jc.82.2.697
1997

Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth homone)-insulin- like growth factor I axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement
Journal of Clinical Endocrinology and Metabolism
Veldhuis, J.D. and Metzger, D.L. and Martha Jr., P.M. and Mauras, N. and Kerrigan, J.R. and Keenan, B. and Rogol, A.D. and Pincus, S.M.
DOI: 10.1210/jc.82.10.3414
1997

Estrogen and diclofenac sodium therapy in a prepubertal female with idiopathic juvenile osteoporosis.
Journal of pediatric endocrinology & metabolism : JPEM
DOI: 10.1515/jpem.1995.8.2.135
PubMed: 7584708
1995

Estrogen and Diclofenac Sodium Therapy in a Prepubertal Female with Idiopathic Juvenile Osteoporosis
Journal of Pediatric Endocrinology and Metabolism
Wright, N.M. and Key, L.L. and Metzger, D.L.
DOI: 10.1515/JPEM.1995.8.2.135
1995

Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans Mechanisms of androgen and estrogen action.
Trends in endocrinology and metabolism: TEM
DOI: 10.1016/1043-2760(94)p3204-k
PubMed: 18407221
09/1994

Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jcem.79.2.8045971
PubMed: 8045971
08/1994

Radiological case of the month. Case 2. Untreated chronic lymphocytic thyroiditis presenting as a pituitary mass and secondary hypocortisolism.
Archives of pediatrics & adolescent medicine
DOI: 10.1001/archpedi.1994.02170070059010
PubMed: 8019626
07/1994

The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group.
Annals of internal medicine
DOI: 10.7326/0003-4819-121-1-199407010-00006
PubMed: 8198345
07/1994

The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis
Annals of Internal Medicine
Caldwell, S.H. and Brantley, K. and Dent, J. and Keeley, R.C. and Pruett, T. and Angle, J.F. and Gaffey, M. and Waldron, P. and Metzger, D.L. and Stevenson, W.C. and Ishitani, M. and Dickson, R.C. and Dye, K.R.
1994

Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans. Mechanisms of androgen and estrogen action
Trends in Endocrinology and Metabolism
Metzger, D.L. and Kerrigan, J.R. and Rogol, A.D.
DOI: 10.1016/1043-2760(94)P3204-K
1994

Cholinergic and opioid involvement in release of growth hormone during exercise and recovery.
Journal of applied physiology (Bethesda, Md. : 1985)
PubMed: 8226493
08/1993

Characterization of pulsatile secretion and clearance of plasma cortisol in premature and term neonates using deconvolution analysis.
The Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jcem.77.2.8345052
PubMed: 8345052
08/1993

Permanent neonatal diabetes mellitus and pancreatic exocrine insufficiency resulting from congenital pancreatic agenesis.
American journal of diseases of children (1960)
PubMed: 8506821
06/1993

Alterations in the neuroendocrine control of growth hormone secretion in the uremic rat.
Kidney international
DOI: 10.1038/ki.1993.146
PubMed: 8099633
05/1993

Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jcem.76.5.8496305
PubMed: 8496305
05/1993

Cholinergic and opioid involvement in release of growth hormone during exercise and recovery
Journal of Applied Physiology
Thompson, D.L. and Weltman, J.Y. and Rogol, A.D. and Metzger, D.L. and Veldhuis, J.D. and Weltman, A.
1993

Permanent Neonatal Diabetes Mellitus and Pancreatic Exocrine Insufficiency Resulting From Congenital Pancreatic Agenesis
American Journal of Diseases of Children
Wright, N.M. and Metzger, D.L. and Borowitz, S.M. and Clarke, W.L.
DOI: 10.1001/archpedi.1993.02160300013005
1993

Research

Current Project
I am currently involved in a multicenter trial involved with the prevention of early treatment of type 1 diabetes: the Diabetes TrialNet.

I am a Co-Investigator on a pan-Canadian study of transgender youth and their families (Trans Youth CAN!).

Honours & Awards

Queen Elizabeth II Diamond Jubilee Medal — 2013

Patient & Family Centred Care Award, BCCH Partners in Care — 2013

Noni MacDonald Award from Paediatrics & Child Health (joint awardee) — 2014

Youth Friendly Care Award of Excellence, BCCH Youth Advisory Committee — 2015

Dr. Harvey Guyda Educator of the Year Award, Canadian Society of Endocrinology and Metabolism — 2016

American Academy of Pediatrics Special Achievement Award — 2018

American Academy of Pediatrics Special Achievement Award — 2021

Most Valuable Teaching Service Award, UBC/BCCH Department of Pediatrics — 2021

Dr. John Hunt Camping Spirit Award, Canadian Diabetes Association — 2004

Dr. Robert Volpé Distinguished Service Award, Canadian Society of Endocrinology and Metabolism — 2021

Education Award of Excellence with Distinction, C&W — 2006

Charles H. Best Award, Canadian Diabetes Association — 2006

Dr. Parminder Singh Award, British Columbia Pediatric Society — 2006

Family-Centred Care Award, BCCH Partners in Care — 2007

Diabetes Champion Certificate of Recognition, Canadian Diabetes Association — 2009

15 Years of Volunteering Recognition Award, Canadian Diabetes Association — 2012

Outstanding Achievement Award, Canadian Diabetes Association — 2003