• Cabral, David A.

    Titles
    Investigator, BC Children's Hospital
    Clinical Professor, Division of Rheumatology, Department of Pediatrics, University of British Columbia
    Degrees / Designations
    MBBS, FRCPC
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2437
    Fax
    604-875-3141
    Lab Phone
    Mailing Address
    BC Children's Hospital
    Room K4-119
    4480 Oak Street
    Vancouver, BC V6H 3V4
    Affiliate Websites
    Research Areas
    • Characterizing the clinical features of rheumatic diseases of children and youth, specifically juvenile idiopathic arthritis, systemic lupus erythematosus and vasculitis while concurrently predicting and improving the outcomes for these children.

    • Facilitating the above research by developing, implementing or participating in national and international Web-based registries of patients with the above rare diseases.

    Summary

    Dr Cabral is the co-founder and current director of the young adult rheumatic disease (YARD) clinic with Mary Pack Arthritis Program of the Vancouver Coastal Health Authority. He has an interest in characterising the processes and difficulties that young adults have in transitioning from the child health care delivery system to the adult system. He is actively involved in clinical and translation research focused on the paediatric rheumatic diseases including chronic arthritis, systemic lupus erythematosus and vasculitis. He is participating in, and involved in the development of, national and international networks and patient registries to facilitate this research.

    Current Projects

    Chronic Arthritides of Childhood
    A productive ad hoc research alliance of Western Canadian paediatric rheumatology centres (in which I was a coinvestigator) provided the model for a successful national endeavor of the Canadian Pediatric Rheumatology Association in obtaining a CIHR New Emerging Team (NET) Grant: New onset juvenile idiopathic arthritis: A Canadian multi-centre collaborative outcomes study (2004). <st1:city w:st="on"><st1:place w:st="on">Vancouver is a core site for this endeavour and Dr Lori Tucker is one of the co-investigators. The early success of this collaboration has also lead to the successful funding of a second grant: Biological based predictors of outcome in JIA: the BBOP study. Again, <st1:city w:st="on"><st1:place w:st="on">Vancouver is also a core center for basic research. Dr Stuart Turvey is a co-investigator. This five year program, unique in <st1:place w:st="on">North America, has already enrolled nearly 500 children with new onset JIA as a cohort of for current and future studies of international significance. Currently, I am a member of the interim steering committee of this research network that has evolved and become known since 2006 as the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI).

    Pediatric vasculitis
    I have lead an initiative since 2004 in the Childhood Arthritis and Rheumatology Research Alliance (CARRA), and established a network of Canadian and American CARRA-associated pediatric Rheumatology centers (more than 50 centers) to study a cohort of patients with the rare Pediatric chronic vasculitides using ‘Web-based’ data entry systems. The initial focus is on Wegener’s granulomatosis and other related small-medium vessel or ANCA-related vasculitidies and is described as A Registry of Childhood Vasculitis: e-entry. ARChiVe. Because of the rarity of these diseases there is limited opportunity to study the unique pediatric clinical features and outcomes with and without various treatments. The current cohort of nearly 50 patients is already double that of any previous study. 

    Systemic lupus erythematosus
    As part of a recently funded "CIHR team in childhood autoimmunity" investigating the common underlying mechanisms and pathways in childhood onset systemic lupus erythematosus (SLE) and diabetes, I am clinical co-investigator for the SLE arm of this study.

    Pediatric Osteoporosis
    I am currently site principal investigator and on the steering committee of a CIHR funded national, multicentre observational study of steroid-induced osteoporosis in the paediatric population.  This cohort of patients with acute lymphatic leukemia, nephrotic syndrome and rheumatic diseases is already the largest of its kind.  The study will provide previously uncharacterised baseline characteristics and natural history of bone health in these populations. This will also establish a basis for collaborative intervention studies. 

    Selected Publications

    Shiff NJ, Abdwani R, Cabral DA, Houghton KM, Malleson PN, Petty RE, Espinosa VM, Tucker LB.: Access to pediatric rheumatology subspecialty care in British Columbia, Canada. J Rheumatol. 2009 Feb;36(2):410-5.

    Cabral DA.: Transition Management. In: Kuchta G, Davidson I, eds; Occupational and physical therapy for children with rheumatic diseases: a clinical handbook. Oxon. Radcliffe Publishing Ltd pp241-246, 2008.

    Cabral, D, Morishita, K.: The Classification of childhood vasculitis. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2008.

    Cabral DA, Morishita K.: Overview of the management of childhood vasculitis, In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2008.

    Wilkinson NMR, Page J, Uribe AG, Espinosa V, Cabral DA. Establishment of a pilot paediatric registry for chronic vasculitis is both essential and feasible: A Childhood Arthritis and Rheumatology Alliance (CARRA) survey. J Rheumatol 2007:34(1)224-6.

    Houghton KM, Page J, Cabral DA, Petty RE, Tucker LB. Systemic lupus erythematosus in the pediatric North American Native population of British Columbia. J Rheumatol 2006;33(1):161-3.

    Oen K, Malleson PN, Cabral DA, Rosenberg AM, Petty RE, Nickerson P, et al. Cytokine genotypes correlate with pain and radiologically defined joint damage in patients with juvenile rheumatoid arthritis. Rheumatology (Oxford) 2005;44(9):1115-21.

    Tucker LB, Cabral DA. Transition of the adolescent patient with rheumatic disease: issues to consider. Pediatr Clin North Am 2005 Apr;52(2):641-52.

    Miettunen PM, Ortiz-Alvarez O, Petty RE, Cimaz R, Malleson PN, Cabral DA, Ensworth S, Tucker LB. Gender and ethnic origin have no effect on longterm outcome of childhood-onset systemic lupus erythematosus. J Rheumatol. 2004 Aug;31(8):1650-4.

    Oen K, Reed M, Malleson PN, Cabral DA, Petty RE, Rosenberg AM, Cheang M. Radiologic outcome and its relationship to functional disability in juvenile rheumatoid arthritis. J Rheumatol. 2003 Apr;30(4):832-40.

    Oen K, Malleson PN, Cabral DA, Rosenberg AM, Petty RE, Reed M, Schroeder ML, Cheang M. Early predictors of longterm outcome in patients with juvenile rheumatoid arthritis: subset-specific correlations. J Rheumatol. 2003 Mar;30(3):585-93.

    Al-Matar MJ, Petty RE, Tucker LB, Malleson PN, Schroeder ML, Cabral DA. The early pattern of joint involvement predicts disease progression in children with oligoarticular (pauciarticular) juvenile rheumatoid arthritis. Arthritis Rheum. 2002 Oct;46(10):2708-15.

    Oen K, Malleson PN, Cabral DA, Rosenberg AM, Petty RE, Cheang M. Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort. J Rheumatol. 2002 Sep;29(9):1989-99.

    Petty RE, Cabral DA. Controversies in Pediatric Rheumatology. Bailliere's Best Practice and Research in Clinical Rheumatology, Vol16, No3, 2002.

    Grants
    Honours & Awards
    Research Group Members