Overview

My research is focused on children who have lost a significant amount of their intestine or whose intestines do not function properly. Often these children have difficulty gaining weight and reaching their growth potential. I am interested in determining how changes to the community gut bacteria in these children can impact their growth and metabolism. Ultimately, I want to find treatments to restore a healthy balance of gut bacteria in these children in order to improve intestinal function, overall nutrition, and growth. I am also interested in determining how changes to the gut bacteria impact the body's immune system and overall level of inflammation potentially predisposing children with intestinal failure to infection, liver disease, and blood clots.

Publications

Standardizing vitamin D supplementation to minimize deficiency in children with intestinal failure
Nutrition in Clinical Practice
Jade Zhong and Debby S. Martins and Hannah G. Piper
DOI: 10.1002/ncp.11094
11/2023

Nutrition considerations in pediatric surgical patients
Nutrition in Clinical Practice
Debby S. Martins and Hannah G. Piper
DOI: 10.1002/ncp.10855
06/2022

Urine sodium to urine creatinine ratio as a marker of total body sodium in infants with intestinal failure
Journal of Pediatric Surgery
Choi, S. and Casey, L. and Albersheim, S. and Van Oerle, R. and Irvine, M.A. and Piper, H.G.
DOI: 10.1016/j.jpedsurg.2021.12.035
2022

Differentiating congenital ovarian cysts from other abdominal cystic lesions in female infants: A study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)
Journal of Pediatric Surgery
Safa, N. and Yanchar, N. and Puligandla, P. and Sewitch, M. and Baird, R. and Beaunoyer, M. and Butter, A. and Campbell, N. and Chadha, R. and Griffiths, C. and Jones, S. and Kaur, M. and Le-Nguyen, A. and Nasr, A. and Piché, N. and Piper, H. and Prasil, P. and Romao, R. and VanHouwelingen, L. and Wales, P. and Guadagno, E. and Emil, S. and for the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)
DOI: 10.1016/j.jpedsurg.2021.12.043
2022

The Importance of the ileocecal valve and colon in achieving intestinal independence in infants with short bowel syndrome
Journal of Pediatric Surgery
Peters, F.B. and Bone, J.N. and Van Oerle, R. and Albersheim, S. and Casey, L. and Piper, H.
DOI: 10.1016/j.jpedsurg.2021.09.028
2022

NeoCHIRP: A model for intestinal rehabilitation in the neonatal intensive care unit
Nutrition in Clinical Practice
Linda M. Casey and Jaclyn Strauss and Keerat K. Dhaliwal and Sonia Butterworth and Hannah G. Piper and Susan G. Albersheim
DOI: 10.1002/ncp.10734
12/2021

Use of instructional videos to reduce central venous catheter complications in children with intestinal failure receiving home parenteral nutrition
Nutrition in Clinical Practice
August Pierik and Debby S. Martins and Linda Casey and Hannah G. Piper
DOI: 10.1002/ncp.10638
08/2021

The effect of daily probiotics on the incidence and severity of necrotizing enterocolitis in infants with very low birth weight
Canadian Journal of Surgery
Que, J. and Van Oerle, R. and Albersheim, S. and Panczuk, J. and Piper, H.
DOI: 10.1503/cjs.016920
2021

Enteral Nutrition in Pediatric Short-Bowel Syndrome
Nutrition in Clinical Practice
Nandini Channabasappa and Sara Girouard and Van Nguyen and Hannah Piper
DOI: 10.1002/ncp.10565
10/2020

The Impact of Lactobacillus Probiotics on the Gut Microbiota in Children With Short Bowel Syndrome.
The Journal of surgical research
Piper HG and Coughlin LA and Hussain S and Nguyen V and Channabasappa N and Koh AY
DOI: 10.1016/j.jss.2020.01.024
PubMed: 32135381
03/2020

A comparison of small bowel and fecal microbiota in children with short bowel syndrome.
Journal of pediatric surgery
Piper HG and Coughlin LA and Nguyen V and Channabasappa N and Koh AY
DOI: 10.1016/j.jpedsurg.2020.01.032
PubMed: 32063370
02/2020

A Comparison of Smoflipid® and Intralipid® in the Early Management of Infants with Intestinal Failure
Journal of Pediatric Surgery
Casson, C. and Nguyen, V. and Nayak, P. and Channabasappa, N. and Berris, K. and Panczuk, J. and Bhiladvala, C. and Dasgupta, T. and Piper, H.G.
DOI: 10.1016/j.jpedsurg.2019.09.073
2020

Access to Paid Parental Leave for Academic Surgeons
Journal of Surgical Research
Itum, D.S. and Oltmann, S.C. and Choti, M.A. and Piper, H.G.
DOI: 10.1016/j.jss.2018.01.001
2019

Pediatric breast masses: an argument for observation
Journal of Surgical Research
Cory M. McLaughlin and Jessica Gonzalez-Hernandez and Monica Bennett and Hannah G. Piper
DOI: 10.1016/j.jss.2018.03.056
08/2018

Intestinal microbiota in short bowel syndrome.
Seminars in pediatric surgery
Piper HG
DOI: 10.1053/j.sempedsurg.2018.07.007
PubMed: 30342596
07/2018

Case 2: A Large Prenatally Undiagnosed Mass in a Preterm Infant, What Could It Be?
NeoReviews
DOI: 10.1542/neo.19-7-e413
07/2018

Anticoagulation results in increased line salvage for children with intestinal failure and central venous thrombosis.
Journal of pediatric surgery
McLaughlin CM and Bennett M and Channabasappa N and Journeycake J and Piper HG
DOI: 10.1016/j.jpedsurg.2018.02.007
PubMed: 29499845
02/2018

A comparison of lipid minimization strategies in children with intestinal failure
Journal of Pediatric Surgery
Gonzalez-Hernandez, J. and Prajapati, P. and Ogola, G. and Nguyen, V. and Channabasappa, N. and Piper, H.G.
DOI: 10.1016/j.jpedsurg.2017.10.030
2018

Growth Trajectory in Children with Short Bowel Syndrome during the First 2 Years of Life
Journal of Pediatric Gastroenterology and Nutrition
McLaughlin, C.M. and Channabasappa, N. and Pace, J. and Nguyen, H. and Piper, H.G.
DOI: 10.1097/MPG.0000000000001762
2018

Growth Trajectory in Children With Short Bowel Syndrome During the First Two Years of Life
Journal of Pediatric Gastroenterology and Nutrition
Cory M. McLaughlin and Nandini Channabasappa and Jesse Pace and Hoa Nguyen and Hannah G. Piper
DOI: 10.1097/mpg.0000000000001762
09/2017

A comparison of Broviac ® and peripherally inserted central catheters in children with intestinal failure
Journal of Pediatric Surgery
Carolina Blotte and Jennifer Styers and Hong Zhu and Nandini Channabasappa and Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2017.01.036
05/2017

Predicting time to full enteral nutrition in children after significant bowel resection
Journal of Pediatric Surgery
Jessica Gonzalez-Hernandez and Purvi Prajapati and Gerald Ogola and Nandini Channabasappa and Barbara Drews and Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2017.01.038
05/2017

Caregiver Education Reduces the Incidence of Community-Acquired CLABSIs in the Pediatric Patient With Intestinal Failure
Gastroenterology Nursing
Barbie Drews and Michelle Macaluso and Hannah Piper and Nandini Channabasappa
DOI: 10.1097/sga.0000000000000274
2017

Severe Gut Microbiota Dysbiosis Is Associated with Poor Growth in Patients with Short Bowel Syndrome
Journal of Parenteral and Enteral Nutrition
Piper, H.G. and Fan, D. and Coughlin, L.A. and Ho, E.X. and McDaniel, M.M. and Channabasappa, N. and Kim, J. and Kim, M. and Zhan, X. and Xie, Y. and Koh, A.Y.
DOI: 10.1177/0148607116658762
2017

Caregiver Education Reduces the Incidence of Community-Acquired CLABSIs in the Pediatric Patient with Intestinal Failure
Gastroenterology Nursing
Drews, B. and Macaluso, M. and Piper, H. and Channabasappa, N.
DOI: 10.1097/SGA.0000000000000274
2017

Central venous thrombosis in children with intestinal failure on long-term parenteral nutrition
Journal of Pediatric Surgery
Jessica Gonzalez-Hernandez and Yahya Daoud and Jennifer Styers and Janna M. Journeycake and Nandini Channabasappa and Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2016.02.024
05/2016

Recent Advances in the Management of Pediatric Short Bowel Syndrome: An Integrative Review of the Literature
Current Surgery Reports
Melody R. Saeman and Hannah G. Piper
DOI: 10.1007/s40137-015-0126-x
01/2016

Endoscopic button gastrostomy: Comparing a sutured endoscopic approach to the current techniques
Journal of Pediatric Surgery
Jessica Gonzalez-Hernandez and Yahya Daoud and Anne C. Fischer and Bradley Barth and Hannah G. Piper
DOI: 10.1016/j.jpedsurg.2015.10.014
01/2016

Intestinal Neuronal Dysplasia-Like Submucosal Ganglion Cell Hyperplasia at the Proximal Margins of Hirschsprung Disease Resections
Pediatric and Developmental Pathology
Maya Swaminathan and Assaf P. Oron and Sumantra Chatterjee and Hannah Piper and Sandy Cope-Yokoyama and Aravinda Chakravarti and Raj P. Kapur
DOI: 10.2350/15-07-1675-oa.1
11/2015

Use of ethanol lock therapy for children with intestinal failure on long-term parenteral nutrition
Diet and Nutrition in Critical Care
Piper, H.G. and Wales, P.W.
DOI: 10.1007/978-1-4614-7836-2_133
2015

Intestinal neuronal dysplasia-like submucosal ganglion cell hyperplasia at the proximal margins of hirschsprung disease resections
Pediatric and Developmental Pathology
Swaminathan, M. and Oron, A.P. and Chatterjee, S. and Piper, H. and Cope-Yokoyama, S. and Chakravarti, A. and Kapur, R.P.
DOI: 10.2350/15-07-1675-OA.1
2015

Use of Ethanol Lock Therapy for Children with Intestinal Failure on Long-Term Parenteral Nutrition
Diet and Nutrition in Critical Care
Hannah G. Piper and Paul W. Wales
DOI: 10.1007/978-1-4614-8503-2_15-1
2014

NOTES suction grasper for tubular viscera - characterization of gripping force when varying hole size, diameter, and number
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Robert J. Brooks and Hannah Piper and Thomas Looi and James Drake
DOI: 10.1109/embc.2013.6610603
07/2013

Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultra-short bowel syndrome
Journal of Pediatric Surgery
Paul W. Wales and Tim Jancelewicz and Rodrigo L. Romao and Hannah G. Piper and Nicole T. de Silva and Yaron Avitzur
DOI: 10.1016/j.jpedsurg.2013.02.015
05/2013

Peripherally Inserted Central Catheters for Long-term Parenteral Nutrition in Infants With Intestinal Failure
Journal of Pediatric Gastroenterology and Nutrition
Hannah G. Piper and Nicole T. de Silva and Joao G. Amaral and Yaron Avitzur and Paul W. Wales
DOI: 10.1097/mpg.0b013e3182801e7b
05/2013

Prevention of catheter-related blood stream infections in children with intestinal failure
Current Opinion in Gastroenterology
Hannah G. Piper and Paul W. Wales
DOI: 10.1097/mog.0b013e328358e268
01/2013

Prevention of catheter-related blood stream infections in children with intestinal failure
Current Opinion in Gastroenterology
Piper, H.G. and Wales, P.W.
DOI: 10.1097/MOG.0b013e328358e268
2013

NOTES suction grasper for tubular viscera - Characterization of gripping force when varying hole size, diameter, and number
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Brooks, R.J. and Piper, H. and Looi, T. and Drake, J.
DOI: 10.1109/EMBC.2013.6610603
2013

Single-incision laparoscopic surgery in children: A randomized control trial of acute appendicitis
Surgical Endoscopy
Perez, E.A. and Piper, H. and Burkhalter, L.S. and Fischer, A.C.
DOI: 10.1007/s00464-012-2617-5
2013

Peripherally inserted central catheters for long-term parenteral nutrition in infants with intestinal failure
Journal of Pediatric Gastroenterology and Nutrition
Piper, H.G. and De Silva, N.T. and Amaral, J.G. and Avitzur, Y. and Wales, P.W.
DOI: 10.1097/MPG.0b013e3182801e7b
2013

Ovarian torsion: diagnosis of inclusion mandates earlier intervention
Journal of Pediatric Surgery
Hannah G. Piper and Sarah C. Oltmann and Lin Xu and Sri Adusumilli and Anne C. Fischer
DOI: 10.1016/j.jpedsurg.2012.06.011
11/2012

Childhood Diseases of the Thyroid and Parathyroid Glands
Pediatric Surgery, 2-Volume Set: Expert Consult - Online and Print
Piper, H.G. and Skinner, M.A.
DOI: 10.1016/B978-0-323-07255-7.00058-1
2012

Childhood Diseases of the Thyroid and Parathyroid Glands
Pediatric Surgery
Hannah G. Piper and Michael A. Skinner
DOI: 10.1016/b978-0-323-07255-7.00058-1
2012

Gracilis transposition flap for repair of an acquired rectovaginal fistula in a pediatric patient
Journal of Pediatric Surgery
Hannah G. Piper and Andrew Trussler and David Schindel
DOI: 10.1016/j.jpedsurg.2011.05.004
08/2011

Is it necessary to drain all postoperative fluid collections after appendectomy for perforated appendicitis?
Journal of Pediatric Surgery
Hannah G. Piper and Betul Derinkuyu and Korgun Koral and Eduardo A. Perez and Joseph T. Murphy
DOI: 10.1016/j.jpedsurg.2011.03.043
06/2011

Detection and Management of Hypothyroidism Following Thyroid Lobectomy: Evaluation of a Clinical Algorithm
Annals of Surgical Oncology
Amanda Johner and Obi L. Griffith and Blair Walker and Leanne Wood and Hannah Piper and Graeme Wilkins and Christopher Baliski and Steven J. M. Jones and Sam M. Wiseman
DOI: 10.1245/s10434-011-1627-1
03/2011

Use of a Continuous Glucose Sensor in an Extracorporeal Life Support Circuit
Journal of Diabetes Science and Technology
Garry M. Steil and Jamin Alexander and Alexandra Papas and Monica Langer and Biren P. Modi and Hannah Piper and Tom Jaksic and Rebecca Gottlieb and Michael S. D. Agus
DOI: 10.1177/193229681100500113
01/2011

Intestinal atresias: factors affecting clinical outcomes
Journal of Pediatric Surgery
Hannah G. Piper and Julia Alesbury and Stephen D. Waterford and David Zurakowski and Tom Jaksic
DOI: 10.1016/j.jpedsurg.2007.09.053
07/2008

Current management of appendicitis at a community center—how can we improve?
The American Journal of Surgery
Hannah G. Piper and Conrad Rusnak and William Orrom and Allen Hayashi and Johann Cunningham
DOI: 10.1016/j.amjsurg.2007.12.033
05/2008

First Report of the International Serial Transverse Enteroplasty Data Registry: Indications, Efficacy, and Complications
Journal of the American College of Surgeons
Biren P. Modi and Patrick J. Javid and Tom Jaksic and Hannah Piper and Monica Langer and Christopher Duggan and Daniel Kamin and Heung Bae Kim
DOI: 10.1016/j.jamcollsurg.2006.12.033
03/2007

Nutrition and Wound Healing at the Age Extremes
Nutrition and Wound Healing
Hannah Piper and Tom Jaksic and Patrick Javid
DOI: 10.1201/9780203500231.ch13
10/2006

Growth and Nutritional Status in Infants With Short-Bowel Syndrome After the Serial Transverse Enteroplasty Procedure
Clinical Gastroenterology and Hepatology
Christopher Duggan and Hannah Piper and Patrick J. Javid and Clarissa Valim and Sharon Collier and Heung Bae Kim and Tom Jaksic
DOI: 10.1016/j.cgh.2006.06.006
10/2006

Nutrition and Wound Healing at the Age Extremes
Nutrition and Wound Healing
Hannah Piper and Tom Jaksic and Patrick Javid
DOI: 10.1201/9780203500231-18
10/2006

Real-Time Continuous Glucose Monitoring in Pediatric Patients During and After Cardiac Surgery
PEDIATRICS
H. G. Piper and J. L. Alexander and A. Shukla and F. Pigula and J. M. Costello and P. C. Laussen and T. Jaksic and M. S.D. Agus
DOI: 10.1542/peds.2006-0347
09/2006

The impact of prenatal bowel dilation on clinical outcomes in neonates with gastroschisis
Journal of Pediatric Surgery
Hannah G. Piper and Tom Jaksic
DOI: 10.1016/j.jpedsurg.2006.01.005
05/2006

The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life support
Annals of Surgery
Agus, M.S.D. and Javid, P.J. and Piper, H.G. and Wypij, D. and Duggan, C.P. and Ryan, D.P. and Jaksic, T.
DOI: 10.1097/01.sla.0000237758.93186.c8
2006

The second STEP: the feasibility of repeat serial transverse enteroplasty
Journal of Pediatric Surgery
Piper, H. and Modi, B.P. and Kim, H.B. and Fauza, D. and Glickman, J. and Jaksic, T.
DOI: 10.1016/j.jpedsurg.2006.08.015
2006

Detecting and defining hypothyroidism after hemithyroidectomy
The American Journal of Surgery
Hannah G. Piper and Samuel P. Bugis and Graeme E. Wilkins and Blair A.M. Walker and Sam Wiseman and Christopher R. Baliski
DOI: 10.1016/j.amjsurg.2005.01.038
05/2005

Burns, Trauma and Critical Care
Manual of Pediatric Nutrition, 4th edition
2005

Models for antigen receptor gene rearrangement. II. Multiple rearrangement in the TCR: Allelic exclusion or inclusion?
Journal of Immunology
Piper, H. and Litwin, S. and Mehr, R.
1999

Research

Current Projects
I am currently conducting a study investigating the use of probiotics as a means to predictably alter the gut microbiota in children with intestinal failure and poor growth. It is unclear whether taking oral probiotics is an effective way to restore balance to the gut bacteria given that many of these patients have rapid intestinal transit and difficulty with absorption. Ultimately, if probiotics prove efficacious, a larger study can be performed to determine the type and duration of therapy that would be most effective.

I am also involved in a study looking at how the gut microbiota contribute to inflammation in the liver of children with intestinal failure who are dependent on intravenous nutrition (parenteral nutrition). It is well known that some children on prolonged parenteral nutrition develop significant hepatic cholestasis and inflammation but the exact etiology of this is not completely understood. Episodes of sepsis, prematurity, the lack of enteral nutrition, and certain components of the parenteral nutrition are all thought to contribute. Recently, there has been evidence to suggest that the intestinal microbiota may also contribute to hepatic inflammation. In this study, I am trying to correlate the abundance of certain species of intestinal bacteria with abnormal hepatic metabolism of propionate (a short chain fatty acid) in children with short bowel syndrome.

Another study I am participating in involves determining if children with short bowel syndrome are predisposed to central venous thrombosis. These children frequently require long-term parenteral nutrition necessitating a functional central venous catheter. Unfortunately, they seem to have an increased incidence of central venous thrombosis compared to other patient groups. A preliminary study that I conducted identified a high incidence of acquired thrombophilia in these children due likely to both systemic inflammation and underlying compromised liver function. I am currently studying the best way to prevent venous thrombosis in these patients including screening and potential anticoagulation.

Grants

"Targeted probiotic therapy to improve the gut microbiota and growth in children with short bowel syndrome"; ASPEN Rhoads Foundation Grant; 1/2017- 1/2018.

"Role of intestial microbiota in children with intestinal failure and bacterial overgrowth"; APSA Foundation Grant; 7/2014- 7/2015.

"The role of the intestinal microbiota in the development of cholestatic liver disease in infants with short bowel syndrome"; Discovery Fund Grant; 1/2016- 1/2017.

Honours & Awards

Gut Microbiota Dysbiosis is Associated with Poor Growth in Children with Show Bowel Syndrome; 2015- 2017.

Provider of the Month Award for the provider who best fulfills the hospital mission; Children's Medical Center, Dallas, Texas; 2016.

Poster with Distinction, International Pediatric Intestinal Failure and Rehabilitation Symposium; 2016.