Overview

Gonadotropin-releasing hormone (GnRH) is a key regulator of mammalian reproduction. After its release from the hypothalamus, this decapeptide hormone is transported from the brain via the portal blood circulation to the anterior pituitary gland, where it stimulates the synthesis and release of the gonadotropins that play pivotal roles in the regulation of the gonads (i.e. ovary and testis). In addition, GnRH has been implicated as an autocrine regulator in several extra-pituitary tissues, including the ovary and placenta, but the specific functions are still unknown. Numerous synthetic analogs of GnRH are now being used in different areas of reproductive medicine, such as assisted reproduction. The long-term goal of my research program is to understand the multi-faceted role of GnRH in reproductive health and medicine.

Publications

Connective tissue growth factor mediates TGF-ß1-induced low-grade serous ovarian tumor cell apoptosis
Oncotarget
DOI: 10.18632/oncotarget.19626
10/2017

SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells
Cellular Signalling
Long Bai, Hsun-Ming Chang, Jung-Chien Cheng, Christian Klausen, Guiyan Chu, Peter C.K. Leung, Gongshe Yang
DOI: 10.1016/j.cellsig.2017.05.017
09/2017

Lithium chloride inhibits StAR and progesterone production through GSK-3ß and ERK1/2 signaling pathways in human granulosa-lutein cells.
Molecular and cellular endocrinology
DOI: 10.1016/j.mce.2017.08.018
PubMed: 28867214
09/2017

Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome.
Clinica chimica acta; international journal of clinical chemistry
DOI: 10.1016/j.cca.2017.06.013
PubMed: 28624500
08/2017

ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells
Endocrinology
Long Bai, Hsun-Ming Chang, Jung-Chien Cheng, Guiyan Chu, Peter C. K Leung, Gongshe Yang
DOI: 10.1210/en.2017-00436
07/2017

Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3ß/ß-Catenin Signaling Pathway
Endocrinology
Long Bai, Hsun-Ming Chang, Jung-Chien Cheng, Guiyan Chu, Peter C K Leung, Gongshe Yang
DOI: 10.1210/en.2017-00287
07/2017

TGF-ß1 Inhibits Human Trophoblast Cell Invasion by Upregulating Connective Tissue Growth Factor Expression
Endocrinology
Jung-Chien Cheng, Hsun-Ming Chang, Peter C. K Leung
DOI: 10.1210/en.2017-00536
07/2017

TGFß1 induces endometrial cancer cell adhesion and migration by up-regulating integrin avß3 via SMAD-independent MEK-ERK1/2 signaling
Cellular Signalling
Siyuan Xiong, Christian Klausen, Jung-Chien Cheng, Peter C.K. Leung
DOI: 10.1016/j.cellsig.2017.03.010
06/2017

Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling
Oncotarget
Qianlan Fan, Yuan Cheng, Hsun-Ming Chang, Masashi Deguchi, Aaron J. Hsueh, Peter C.K. Leung
DOI: 10.18632/oncotarget.15677
04/2017

Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.
EBioMedicine
DOI: 10.1016/j.ebiom.2017.01.011
PubMed: 28111236
02/2017

HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis.
Reproductive sciences (Thousand Oaks, Calif.)
DOI: 10.1177/1933719117732164
PubMed: 28969513
01/2017

Growth hormone-releasing hormone antagonist inhibits the invasiveness of human endometrial cancer cells by down-regulating twist and N-cadherin expression
Oncotarget
Hsien-Ming Wu, Hong-Yuan Huang, Andrew V. Schally, Angel Chao, Hung-Hsueh Chou, Peter C.K. Leung, Hsin-Shih Wang
DOI: 10.18632/oncotarget.13877
01/2017

Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors.
Human reproduction update
DOI: 10.1093/humupd/dmw039
PubMed: 27797914
12/2016

Low Thyroid Hormone in Early Pregnancy Is Associated With an Increased Risk of Gestational Diabetes Mellitus.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2016-1506
PubMed: 27583471
11/2016

Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation
Cellular Signalling
Jianfang Zhao, Christian Klausen, Siyuan Xiong, Jung-Chien Cheng, Hsun-Ming Chang, Peter C.K. Leung
DOI: 10.1016/j.cellsig.2016.07.013
11/2016

Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells
Oncotarget
Jung-Chien Cheng, Hsun-Ming Chang, Siyuan Xiong, Wai-Kin So, Peter C. K. Leung
DOI: 10.18632/oncotarget.13162
11/2016

Connective tissue growth factor mediates growth differentiation factor 8-induced increase of lysyl oxidase activity in human granulosa-lutein cells
Molecular and Cellular Endocrinology
Hsun-Ming Chang, Ying Fang, Pang-Pin Liu, Jung-Chien Cheng, Xiaokui Yang, Peter C.K. Leung
DOI: 10.1016/j.mce.2016.07.007
10/2016

Activin A upregulates PTGS2 expression and increases PGE2 production in human granulosa-lutein cells
Reproduction
Pang-Pin Liu, Hsun-Ming Chang, Jung-Chien Cheng, Peter C K Leung
DOI: 10.1530/rep-16-0262
09/2016

TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways
Oncotarget
Siyuan Xiong, Jung-Chien Cheng, Christian Klausen, Jianfang Zhao, Peter C.K. Leung
DOI: 10.18632/oncotarget.11311
08/2016

Activin A-induced increase in LOX activity in human granulosa–lutein cells is mediated by CTGF
Reproduction
Hsun-Ming Chang, Jung-Chien Cheng, Yingtao Liu, Christian Klausen, Congjian Xu, Peter C K Leung
DOI: 10.1530/rep-16-0254
08/2016

Sprouty4 mediates amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
DOI: 10.1007/s13277-016-4790-y
PubMed: 26768617
07/2016

Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling
Cellular Signalling
Jung-Chien Cheng, Hsun-Ming Chang, Pang-Pin Liu, Peter C.K. Leung
DOI: 10.1016/j.cellsig.2016.03.006
06/2016

Transforming growth factor-ß1 increases lysyl oxidase expression by downregulating MIR29A in human granulosa lutein cells
Reproduction
Ying Fang, Hsun-Ming Chang, Jung-Chien Cheng, Christian Klausen, Peter C K Leung, Xiaokui Yang
DOI: 10.1530/rep-16-0144
06/2016

Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells.
Molecular and cellular endocrinology
DOI: 10.1016/j.mce.2016.03.016
PubMed: 26992562
06/2016

Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor are expressed at tubal ectopic pregnancy implantation sites
Fertility and Sterility
Bo Peng, Christian Klausen, Lisa Campbell, Peter C.K. Leung, Andrew W. Horne, Mohamed A. Bedaiwy
DOI: 10.1016/j.fertnstert.2016.02.003
06/2016

Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling
Oncotarget
Siyuan Xiong, Christian Klausen, Jung-Chien Cheng, Peter C.K. Leung
DOI: 10.18632/oncotarget.9483
05/2016

Betacellulin induces Slug-mediated down-regulation of E-cadherin and cell migration in ovarian cancer cells.
Oncotarget
DOI: 10.18632/oncotarget.7591
PubMed: 27129169
05/2016

Whole exome sequencing in recurrent early pregnancy loss.
Molecular human reproduction
DOI: 10.1093/molehr/gaw008
PubMed: 26826164
05/2016

Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells
Fertility and Sterility
Hsun-Ming Chang, Lanlan Fang, Jung-Chien Cheng, Elizabeth L. Taylor, Ying-Pu Sun, Peter C.K. Leung
DOI: 10.1016/j.fertnstert.2015.10.034
02/2016

Growth differentiation factor 8 suppresses cell proliferation by up-regulating CTGF expression in human granulosa cells
Molecular and Cellular Endocrinology
Hsun-Ming Chang, Hui-Hui Pan, Jung-Chien Cheng, Yi-Min Zhu, Peter C.K. Leung
DOI: 10.1016/j.mce.2015.11.009
02/2016

EGF-Induced Connexin43 Negatively Regulates Cell Proliferation in Human Ovarian Cancer.
Journal of cellular physiology
DOI: 10.1002/jcp.25058
PubMed: 26031779
01/2016

Bone morphogenetic protein 2 regulates cell–cell communication by down-regulating connexin43 expression in luteinized human granulosa cells
Molecular Human Reproduction
Yan-Ting Wu, Hsun-Ming Chang, He-Feng Huang, Jian-Zhong Sheng, Peter C.K. Leung
DOI: 10.1093/molehr/gaw078
2016

Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line.
Current molecular medicine
DOI: 10.2174/1566524016666160225154040
PubMed: 26917260
2016

hCG-induced Sprouty2 mediates amphiregulin-stimulated COX-2/PGE2 up-regulation in human granulosa cells: a potential mechanism for the OHSS.
Scientific reports
DOI: 10.1038/srep31675
PubMed: 27539669
2016

BMP4 and BMP7 Suppress StAR and Progesterone Production via ALK3 and SMAD1/5/8-SMAD4 in Human Granulosa-Lutein Cells
Endocrinology
Han Zhang, Christian Klausen, Hua Zhu, Hsun-Ming Chang, Peter C. K. Leung
DOI: 10.1210/en.2015-1494
11/2015

Activin A Increases Human Trophoblast Invasion by Inducing SNAIL-Mediated MMP2 Up-Regulation Through ALK4
The Journal of Clinical Endocrinology & Metabolism
Yan Li, Christian Klausen, Hua Zhu, Peter C. K. Leung
DOI: 10.1210/jc.2015-2134
11/2015

Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation
Endocrinology
Yan Li, Hua Zhu, Christian Klausen, Bo Peng, Peter C. K. Leung
DOI: 10.1210/en.2015-1228
11/2015

Transforming growth factor-ß stimulates human ovarian cancer cell migration by up-regulating connexin43 expression via Smad2/3 signaling
Cellular Signalling
Xin Qiu, Jung-Chien Cheng, Jianfang Zhao, Hsun-Ming Chang, Peter C.K. Leung
DOI: 10.1016/j.cellsig.2015.07.010
10/2015

Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells.
Molecular and cellular endocrinology
DOI: 10.1016/j.mce.2015.05.016
PubMed: 26001835
09/2015

Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling
Oncotarget
Siyuan Xiong, Christian Klausen, Jung-Chien Cheng, Hua Zhu, Peter C.K. Leung
DOI: 10.18632/oncotarget.5229
08/2015

CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.
Cell death & disease
DOI: 10.1038/cddis.2015.229
PubMed: 26313915
08/2015

Transforming growth factor-ß1 up-regulates connexin43 expression in human granulosa cells
Human Reproduction
Yu-Ching Chen, Hsun-Ming Chang, Jung-Chien Cheng, Horng-Der Tsai, Cheng-Hsuan Wu, Peter C.K. Leung
DOI: 10.1093/humrep/dev175
07/2015

AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion
Endocrinology
Bo Peng, Hua Zhu, Liyang Ma, Yan-ling Wang, Christian Klausen, Peter C. K. Leung
DOI: 10.1210/en.2014-1871
06/2015

TGF-ß1 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways
PLOS ONE
Jung-Chien Cheng, Hsun-Ming Chang, Lanlan Fang, Ying-Pu Sun, Peter C. K. Leung
DOI: 10.1371/journal.pone.0126532
05/2015

Transforming growth factor-a induces human ovarian cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner.
Biochemical and biophysical research communications
DOI: 10.1016/j.bbrc.2015.03.180
PubMed: 25869072
05/2015

Alternative splicing of the androgen receptor in polycystic ovary syndrome.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1418216112
PubMed: 25825716
04/2015

Gonadotropin-Releasing Hormone Type II (GnRH-II) Agonist Regulates the Motility of Human Decidual Endometrial Stromal Cells: Possible Effect on Embryo Implantation and Pregnancy
Biology of Reproduction
DOI: 10.1095/biolreprod.114.127324
04/2015

Recombinant BMP4 and BMP7 Increase Activin A Production by Up-Regulating Inhibin ßA Subunit and Furin Expression in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang, Jung-Chien Cheng, Christian Klausen, Peter C.K. Leung
DOI: 10.1210/jc.2014-3026
03/2015

Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells
Molecular and Cellular Endocrinology
Hsun-Ming Chang, Lanlan Fang, Jung-Chien Cheng, Christian Klausen, Ying-Pu Sun, Peter C.K. Leung
DOI: 10.1016/j.mce.2015.01.036
03/2015

TGF-ß1 up-regulates connexin43 expression: A potential mechanism for human trophoblast cell differentiationTGF-ß1-INDUCED TROPHOBLAST DIFFERENTIATION
Journal of Cellular Physiology
Jung-Chien Cheng, Hsun-Ming Chang, Lanlan Fang, Ying-Pu Sun, Peter C.K. Leung
DOI: 10.1002/jcp.24902
03/2015

Recombinant BMP4 and BMP7 Downregulate Pentraxin 3 in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang, Jung-Chien Cheng, Lanlan Fang, Xin Qiu, Christian Klausen, Elizabeth L. Taylor, Peter C.K. Leung
DOI: 10.1210/jc.2014-2496
03/2015

EpCAM is up-regulated by EGF via ERK1/2 signaling and suppresses human epithelial ovarian cancer cell migration.
Biochemical and biophysical research communications
DOI: 10.1016/j.bbrc.2014.12.097
PubMed: 25576358
02/2015

Nitric Oxide and cGMP Induce COX-2 Expression and PGE2Production in Human Granulosa Cells Through CREB Signaling Pathway
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang, Hsun-Ming Chang, Jung-Chien Cheng, Peter C. K. Leung, Ying-Pu Sun
DOI: 10.1210/jc.2014-2886
02/2015

Loss of Sprouty2 in human high-grade serous ovarian carcinomas promotes EGF-induced E-cadherin down-regulation and cell invasion.
FEBS letters
DOI: 10.1016/j.febslet.2014.12.012
PubMed: 25533808
01/2015

Gonadotropin-Releasing Hormone Regulates Human Trophoblastic Cell Invasion via TWIST-Induced N-cadherin Expression
The Journal of Clinical Endocrinology & Metabolism
Bo Peng, Hua Zhu, Peter C.K. Leung
DOI: 10.1210/jc.2014-1897
01/2015

GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression
Molecular Human Reproduction
Bo Peng, Hua Zhu, Christian Klausen, Liyang Ma, Yan-ling Wang, Peter C.K. Leung
DOI: 10.1093/molehr/gav070
2015

Growth Differentiation Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells
Endocrinology
Lanlan Fang, Hsun-Ming Chang, Jung-Chien Cheng, Yiping Yu, Peter C. K. Leung, Ying-Pu Sun
DOI: 10.1210/en.2015-1461
2015

Functional consequences of copy number variants in miscarriage.
Molecular cytogenetics
DOI: 10.1186/s13039-015-0109-8
PubMed: 25674159
2015

TGF-ß1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang, Hsun-Ming Chang, Jung-Chien Cheng, Peter C. K. Leung, Ying-Pu Sun
DOI: 10.1210/jc.2014-1930
11/2014

Amphiregulin induces human ovarian cancer cell invasion by down-regulating E-cadherin expression.
FEBS letters
DOI: 10.1016/j.febslet.2014.09.017
PubMed: 25261255
11/2014

Activin A, B, and AB Increase Human Trophoblast Cell Invasion by Up-regulating N-Cadherin
The Journal of Clinical Endocrinology & Metabolism
Yan Li, Christian Klausen, Jung-Chien Cheng, Hua Zhu, Peter C. K. Leung
DOI: 10.1210/jc.2014-2118
11/2014

Effects of Recombinant Activins on Steroidogenesis in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang, Jung-Chien Cheng, Christian Klausen, Elizabeth L. Taylor, Peter C. K. Leung
DOI: 10.1210/jc.2014-1223
10/2014

COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion.
Endocrine-related cancer
DOI: 10.1530/erc-13-0450
PubMed: 24969217
08/2014

TGF-ß1 Induces COX-2 Expression and PGE2 Production in Human Granulosa Cells Through Smad Signaling Pathways
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang, Hsun-Ming Chang, Jung-Chien Cheng, Peter C. K. Leung, Ying-Pu Sun
DOI: 10.1210/jc.2013-4100
07/2014

Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells.
Molecular human reproduction
DOI: 10.1093/molehr/gau001
PubMed: 24413384
05/2014

FOXL2-induced follistatin attenuates activin A-stimulated cell proliferation in human granulosa cell tumors
Biochemical and Biophysical Research Communications
Jung-Chien Cheng, Hsun-Ming Chang, Xin Qiu, Lanlan Fang, Peter C.K. Leung
DOI: 10.1016/j.bbrc.2013.12.010
01/2014

Transforming growth factor-ß1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein.
The Journal of biological chemistry
DOI: 10.1074/jbc.m113.488866
PubMed: 24106276
11/2013

Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha
Biochemical and Biophysical Research Communications
Yu Zhang, Jung-Chien Cheng, He-Feng Huang, Peter C.K. Leung
DOI: 10.1016/j.bbrc.2013.09.121
11/2013

Gonadal steroids regulate the expression of aggrecanases in human endometrial stromal cellsin vitro
Journal of Cellular and Molecular Medicine
Jiadi Wen, Hua Zhu, Peter C.K. Leung
DOI: 10.1111/jcmm.12110
08/2013

Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2.
BMC cancer
DOI: 10.1186/1471-2407-13-300
PubMed: 23786715
06/2013

HER2 mediates epidermal growth factor-induced down-regulation of E-cadherin in human ovarian cancer cells.
Biochemical and biophysical research communications
DOI: 10.1016/j.bbrc.2013.03.062
PubMed: 23542467
04/2013

Theca-Derived BMP4 and BMP7 Down-Regulate Connexin43 Expression and Decrease Gap Junction Intercellular Communication Activity in Immortalized Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang, Jung-Chien Cheng, Peter C. K. Leung
DOI: 10.1210/jc.2012-3851
03/2013

Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways.
Molecular human reproduction
DOI: 10.1093/molehr/gas055
PubMed: 23184927
03/2013

Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells.
Oncogene
DOI: 10.1038/onc.2012.127
PubMed: 22508482
02/2013

Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
Cancer Letters
Jung-Chien Cheng, Christian Klausen, Peter C.K. Leung
DOI: 10.1016/j.canlet.2012.10.029
02/2013

Targeting Gonadotropin-releasing Hormone Receptor Inhibits the Early Step of Ovarian Cancer Metastasis by Modulating Tumor-mesothelial Adhesion
Molecular Therapy
Lydia WT Cheung, Susan Yung, Tak-Mao Chan, Peter CK Leung, Alice ST Wong
DOI: 10.1038/mt.2012.187
01/2013

Overexpression of Wild-Type but Not C134W Mutant FOXL2 Enhances GnRH-Induced Cell Apoptosis by Increasing GnRH Receptor Expression in Human Granulosa Cell Tumors
PLoS ONE
Jung-Chien Cheng, Christian Klausen, Peter C. K. Leung
DOI: 10.1371/journal.pone.0055099
01/2013

Molecular mechanism(s) of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors.
Journal of cellular and molecular medicine
DOI: 10.1111/j.1582-4934.2012.01649.x
PubMed: 23279634
01/2013

EGF-like Growth Factors Induce COX-2–Derived PGE2 Production Through ERK1/2 in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang, Jung-Chien Cheng, Hsun-Ming Chang, Ying-Pu Sun, Peter C. K. Leung
DOI: 10.1210/jc.2013-2662
2013

BMP15 Suppresses Progesterone Production by Down-Regulating StAR via ALK3 in Human Granulosa Cells
Molecular Endocrinology
Hsun-Ming Chang, Jung-Chien Cheng, Christian Klausen, Peter C. K. Leung
DOI: 10.1210/me.2013-1233
2013

Fibroblast growth factor 2 induces E-cadherin down-regulation via PI3K/Akt/mTOR and MAPK/ERK signaling in ovarian cancer cells.
PloS one
DOI: 10.1371/journal.pone.0059083
PubMed: 23554977
2013

Epidermal Growth Factor Induces Human Oviductal Epithelial Cell Invasion by Down-Regulating E-Cadherin Expression
The Journal of Clinical Endocrinology & Metabolism
Jung-Chien Cheng, Hsun-Ming Chang, Peter C. K. Leung
DOI: 10.1210/jc.2011-2751
08/2012

A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells.
Journal of molecular medicine (Berlin, Germany)
DOI: 10.1007/s00109-012-0881-4
PubMed: 22349439
08/2012

TGF-Beta Induces Serous Borderline Ovarian Tumor Cell Invasion by Activating EMT but Triggers Apoptosis in Low-Grade Serous Ovarian Carcinoma Cells
PLoS ONE
Jung-Chien Cheng, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1371/journal.pone.0042436
08/2012

The Human Gonadotropin-Inhibitory Hormone Ortholog RFamide-Related Peptide-3 Suppresses Gonadotropin-Induced Progesterone Production in Human Granulosa Cells
Endocrinology
Hajime Oishi, Christian Klausen, George E. Bentley, Tomohiro Osugi, Kazuyoshi Tsutsui, C. Blake Gilks, Tetsu Yano, Peter C. K. Leung
DOI: 10.1210/en.2012-1066
07/2012

Integrin ß1 mediates epithelial growth factor-induced invasion in human ovarian cancer cells
Cancer Letters
Man-Tat Lau, Wai-Kin So, Peter C.K. Leung
DOI: 10.1016/j.canlet.2012.02.028
07/2012

Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia.
Diabetes
DOI: 10.2337/db11-1314
PubMed: 22447856
05/2012

Gonadotropin-Releasing Hormone-I or -II Interacts with IGF-I/Akt But Not Connexin 43 in Human Granulosa Cell Apoptosis
The Journal of Clinical Endocrinology & Metabolism
In-Sun Hong, C. Klausen, Anthony P. Cheung, Peter C. K. Leung
DOI: 10.1210/jc.2011-1229
02/2012

Twist Modulates Human Trophoblastic Cell Invasion via Regulation of N-Cadherin
Endocrinology
York Hunt Ng, Hua Zhu, Peter C. K. Leung
DOI: 10.1210/en.2011-1488
02/2012

Gonadotrophin-releasing hormone antagonist induces apoptosis in human decidual stromal cells: effect on GADD45  and MAPK signaling
Human Reproduction
H.-M. Wu, H.-S. Wang, Y.-K. Soong, H.-Y. Huang, C.-K. Chen, C.-L. Lee, P. C. K. Leung
DOI: 10.1093/humrep/der460
01/2012

The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells
Cancer Letters
Man-Tat Lau, Peter C.K. Leung
DOI: 10.1016/j.canlet.2012.08.016
2012

EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
PloS one
DOI: 10.1371/journal.pone.0034071
PubMed: 22479527
2012

Identification of Estrogen Response Element in the Aquaporin-2 Gene That Mediates Estrogen-Induced Cell Migration and Invasion in Human Endometrial Carcinoma
The Journal of Clinical Endocrinology & Metabolism
Li-Bo Zou, Run-Ju Zhang, Ya-Jing Tan, Guo-Lian Ding, Shuai Shi, Dan Zhang, Rong-Huan He, Ai-Xia Liu, Ting-Ting Wang, Peter C. K. Leung, Jian-Zhong Sheng, He-Feng Huang
DOI: 10.1210/jc.2011-0426
09/2011

Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells.
Oncogene
DOI: 10.1038/onc.2011.117
PubMed: 21478913
09/2011

Wild-Type p53 Attenuates Cancer Cell Motility by Inducing Growth Differentiation Factor-15 Expression
Endocrinology
Jung-Chien Cheng, Hsun-Ming Chang, Peter C. K. Leung
DOI: 10.1210/en.2011-0059
08/2011

Growth Differentiation Factor 9 (GDF9) Suppresses Follistatin and Follistatin-Like 3 Production in Human Granulosa-Lutein Cells
PLoS ONE
Feng-Tao Shi, Anthony P. Cheung, He-Feng Huang, Peter C. K. Leung
DOI: 10.1371/journal.pone.0022866
08/2011

Anti-Mu¨llerian Hormone Inhibits FSH-Induced Adenylyl Cyclase Activation, Aromatase Expression, and Estradiol Production in Human Granulosa-Lutein Cells.
Biology of Reproduction
Hsun Ming Chang, Christian Klausen, Peter C.K. Leung
DOI: 10.1093/biolreprod/85.s1.392
07/2011

P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin.
Oncogene
DOI: 10.1038/onc.2011.7
PubMed: 21317933
06/2011

E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via ß-catenin-Egr1-mediated PTEN expression.
Oncogene
DOI: 10.1038/onc.2011.6
PubMed: 21297666
06/2011

Type I collagen down-regulates E-cadherin expression by increasing PI3KCA in cancer cells.
Cancer letters
DOI: 10.1016/j.canlet.2011.02.008
PubMed: 21377268
05/2011

Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?
PloS one
DOI: 10.1371/journal.pone.0018473
PubMed: 21494557
04/2011

Gonadotropin-Releasing Hormone-II Increases Membrane Type I Metalloproteinase Production via ß-Catenin Signaling in Ovarian Cancer Cells
Endocrinology
Song Ling Poon, Man-Tat Lau, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/en.2010-0942
03/2011

Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2010-2192
PubMed: 21177787
03/2011

Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin.
Oncogene
DOI: 10.1038/onc.2010.486
PubMed: 20972462
03/2011

37-kDa Laminin Receptor Precursor Mediates GnRH-II–Induced MMP-2 Expression and Invasiveness in Ovarian Cancer Cells
The Journal of Clinical Endocrinology & Metabolism
Song Ling Poon, Christian Klausen, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/jcem.96.2.zeg557b
02/2011

Twist Regulates Cadherin-Mediated Differentiation and Fusion of Human Trophoblastic Cells
The Journal of Clinical Endocrinology & Metabolism
York Hunt Ng, Hua Zhu, Peter C. K. Leung
DOI: 10.1210/jc.2010-2714
2011

Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle
Reproductive Biology and Endocrinology
Hyun Yang, Tae-Hee Kim, Hae-Hyeog Lee, Kyung-Chul Choi, Yeon-pyo Hong, Peter CK Leung, Eui-Bae Jeung
DOI: 10.1186/1477-7827-9-28
2011

G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve
Fertility and Sterility
Ting-Ting Wang, Yan-Ting Wu, Min-Yue Dong, Jian-Zhong Sheng, Peter C.K. Leung, He-Feng Huang
DOI: 10.1016/j.fertnstert.2010.03.070
11/2010

Growth Differentiation Factor 9 Reverses Activin A Suppression of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Feng-Tao Shi, Anthony P. Cheung, Christian Klausen, He-Feng Huang, Peter C. K. Leung
DOI: 10.1210/jc.2010-0477
10/2010

Hydrogen Peroxide Mediates EGF-Induced Down-Regulation of E-Cadherin Expression via p38 MAPK and Snail in Human Ovarian Cancer Cells
Molecular Endocrinology
Jung-Chien Cheng, Christian Klausen, Peter C. K. Leung
DOI: 10.1210/me.2010-0034
08/2010

Gonadotropins Induce Tumor Cell Migration and Invasion by Increasing Cyclooxygenases Expression and Prostaglandin E2Production in Human Ovarian Cancer Cells
Endocrinology
Man-Tat Lau, Alice S. T. Wong, Peter C. K. Leung
DOI: 10.1210/en.2009-1318
07/2010

Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer.
Oncogene
DOI: 10.1038/onc.2009.523
PubMed: 20118984
04/2010

Gonadotropin-Releasing Hormone-I-Mediated Activation of Progesterone Receptor Contributes to Gonadotropin a-Subunit Expression in Mouse Gonadotrophs
Endocrinology
Junling Chen, Beum-Soo An, Wai-Kin So, Linan Cheng, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/en.2009-0816
03/2010

Influence of the prodrugs 5-fluorocytosine and CPT-11 on ovarian cancer cells using genetically engineered stem cells: tumor-tropic potential and inhibition of ovarian cancer cell growth
Cancer Science
Ki-Yon Kim, Seung U. Kim, Peter C. K. Leung, Eui-Bae Jeung, Kyung-Chul Choi
DOI: 10.1111/j.1349-7006.2009.01485.x
02/2010

Oviductal Glycoprotein (OVGP1, MUC9)A Differentiation-Based Mucin Present in Serum of Women With Ovarian Cancer
International Journal of Gynecological Cancer
Sarah Maines-Bandiera, Michelle M.M. Woo, Marilyn Borugian, Laurie L. Molday, Theresa Hii, Blake Gilks, Peter C.K. Leung, Robert S. Molday, Nelly Auersperg
DOI: 10.1111/igc.0b013e3181bcc96d
01/2010

Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia.
BJOG : an international journal of obstetrics and gynaecology
DOI: 10.1111/j.1471-0528.2009.02428.x
PubMed: 20002372
01/2010

Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth
Carcinogenesis
Jung-Hye Choi, Kyung-Tae Lee, Peter C.K. Leung
DOI: 10.1093/carcin/bgq276
2010

Growth hormone-releasing hormone antagonist induces apoptosis of human endometrial cancer cells through PKCd-mediated activation of p53/p21
Cancer Letters
Hsien-Ming Wu, Andrew V. Schally, Jung-Chien Cheng, Marta Zarandi, Jozsef Varga, Peter C.K. Leung
DOI: 10.1016/j.canlet.2010.05.022
2010

Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway
Reproductive Biology and Endocrinology
Jian Guo, Andrew V Schally, Marta Zarandi, Jozsef Varga, Peter CK Leung
DOI: 10.1186/1477-7827-8-54
2010

Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells
Reproductive Biology and Endocrinology
Yu Zhang, Qing Huang, Jung-Chien Cheng, Yoshihiro Nishi, Toshihiko Yanase, He-Feng Huang, Peter CK Leung
DOI: 10.1186/1477-7827-8-61
2010

Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-7-144
PubMed: 19968870
12/2009

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.
PloS one
DOI: 10.1371/journal.pone.0007988
PubMed: 19956657
11/2009

Gonadotropin-Releasing Hormone-Mediated Phosphorylation of Estrogen Receptor-a Contributes to fosB Expression in Mouse Gonadotrophs
Endocrinology
DOI: 10.1210/en.2009-0455
10/2009

Epidermal Growth Factor-Induced GnRH-II Synthesis Contributes to Ovarian Cancer Cell Invasion
The Journal of Clinical Endocrinology & Metabolism
Song Ling Poon, Gareth T. Hammond, Peter C. K. Leung
DOI: 10.1210/jcem.94.9.9996
09/2009

Cell Motility and Spreading Are Suppressed by HOXA4 in Ovarian Cancer Cells: Possible Involvement of  1 Integrin
Molecular Cancer Research
C. Klausen, P. C.K. Leung, N. Auersperg
DOI: 10.1158/1541-7786.mcr-08-0466
09/2009

Rapid effect of GNRH1 on follicle-stimulating hormone beta gene expression in LbetaT2 mouse pituitary cells requires the progesterone receptor.
Biology of reproduction
DOI: 10.1095/biolreprod.109.076216
PubMed: 19357364
08/2009

Growth Differentiation Factor 9 Enhances Activin A-Induced Inhibin B Production in Human Granulosa Cells
Endocrinology
Feng-Tao Shi, Anthony P. Cheung, Peter C. K. Leung
DOI: 10.1210/en.2009-0267
08/2009

Clinical and endocrine response to the withdrawal of gonadotropin-releasing hormone agonists during prolonged coasting
Fertility and Sterility
Basil Ho Yuen, Tuan-Anh T. Nguyen, Anthony P. Cheung, Peter C.K. Leung
DOI: 10.1016/j.fertnstert.2008.06.039
08/2009

Promotion of Human Trophoblasts Invasion by Gonadotropin-Releasing Hormone (GnRH) I and GnRH II via Distinct Signaling Pathways
Molecular Endocrinology
Jing Liu, Colin D. MacCalman, Yan-ling Wang, Peter C. K. Leung
DOI: 10.1210/me.2008-0451
07/2009

Mutation of FOXL2 in granulosa-cell tumors of the ovary.
The New England journal of medicine
DOI: 10.1056/nejmoa0902542
PubMed: 19516027
06/2009

Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation.
American journal of physiology. Endocrinology and metabolism
DOI: 10.1152/ajpendo.90929.2008
PubMed: 19366876
06/2009

Gonadotropin-releasing hormone type II induces apoptosis of human endometrial cancer cells by activating GADD45alpha.
Cancer research
DOI: 10.1158/0008-5472.can-08-4591
PubMed: 19366794
05/2009

GnRH signaling in intrauterine tissues.
Reproduction (Cambridge, England)
DOI: 10.1530/rep-08-0397
PubMed: 19208750
05/2009

Gonadotropin-stimulated epidermal growth factor receptor expression in human ovarian surface epithelial cells: involvement of cyclic AMP-dependent exchange protein activated by cAMP pathway.
Endocrine-related cancer
DOI: 10.1677/erc-07-0238
PubMed: 19022848
03/2009

Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells
Differentiation
Takayo Ota, Christian Klausen, M. Clara Salamanca, Henry L. Woo, Peter C.K. Leung, Nelly Auersperg
DOI: 10.1016/j.diff.2008.09.018
02/2009

Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38.
The Journal of reproduction and development
DOI: 10.1262/jrd.20094
PubMed: 18854640
02/2009

Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: Involvement of integrin beta3 and focal adhesion kinase
Reproductive Biology and Endocrinology
Dong Park, Kyung-Chul Choi, Colin D MacCalman, Peter CK Leung
DOI: 10.1186/1477-7827-7-81
2009

Effects of Endogenous Growth Differentiation Factor 9 on Activin A-Induced Inhibin B Production in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Feng-Tao Shi, Anthony P. Cheung, He-Feng Huang, Peter C. K. Leung
DOI: 10.1210/jc.2009-1047
2009

Transcripts of testicular gonadotropin-releasing hormone, steroidogenic enzymes, and intratesticular testosterone levels in infertile men
Fertility and Sterility
Yung Ming Lin, Song Ling Poon, Jung Hye Choi, Johnny Shinn Nan Lin, Peter C.K. Leung, Bu Miin Huang
DOI: 10.1016/j.fertnstert.2007.08.078
11/2008

Temporal Recruitment of Transcription Factors at the 3',5'-Cyclic Adenosine 5'-Monophosphate-Response Element of the HumanGnRH-IIPromoter
Endocrinology
Song Ling Poon, Beum-Soo An, Wai-Kin So, Geoffrey L. Hammond, Peter C. K. Leung
DOI: 10.1210/en.2008-0481
10/2008

Gonadotropin-releasing hormone and ovarian cancer: a functional and mechanistic overviewGnRH and ovarian cancer
FEBS Journal
Wai-Kin So, Jung-Chien Cheng, Song-Ling Poon, Peter C. K. Leung
DOI: 10.1111/j.1742-4658.2008.06679.x
10/2008

SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.
Gynecologic oncology
DOI: 10.1016/j.ygyno.2008.06.021
PubMed: 18678400
10/2008

Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha.
Molecular Endocrinology
DOI: 10.1210/me.2007-0512
PubMed: 18550773
09/2008

Gonadotropin-Releasing Hormones I and II Induce Apoptosis in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
In-Sun Hong, Anthony P. Cheung, Peter C. K. Leung
DOI: 10.1210/jc.2008-0127
08/2008

Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
Journal of cell science
DOI: 10.1242/jcs.013029
PubMed: 18270270
03/2008

Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells.
Molecular pharmacology
DOI: 10.1124/mol.107.041087
PubMed: 18042733
03/2008

Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells.
American journal of physiology. Endocrinology and metabolism
DOI: 10.1152/ajpendo.00480.2007
PubMed: 18056793
02/2008

Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
DOI: 10.1111/j.1525-1438.2007.01171.x
PubMed: 18217967
2008

HOX cofactors expression and regulation in the human ovary
Reproductive Biology and Endocrinology
Takayo Ota, Haruka Asahina, Se-Hyung Park, Qing Huang, Takashi Minegishi, Nelly Auersperg, Peter CK Leung
DOI: 10.1186/1477-7827-6-49
2008

HOXA7 in Epithelial Ovarian Cancer: Interrelationships Between Differentiation and Clinical Features
Reproductive Sciences
Takayo Ota, C. Blake Gilks, Teri Longacre, Peter C. K. Leung, Nelly Auersperg
DOI: 10.1177/1933719107307781
09/2007

Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion
Endocrine
Chien-Lin Chen, Lydia W. T. Cheung, Man-Tat Lau, Jung-Hye Choi, Nelly Auersperg, Hsin-Shih Wang, Alice S. T. Wong, Peter C. K. Leung
DOI: 10.1007/s12020-007-0041-8
07/2007

Gonadotropins and Ovarian Cancer
Endocrine Reviews
Jung-Hye Choi, Alice S. T. Wong, He-Feng Huang, Peter C. K. Leung
DOI: 10.1210/er.2006-0036
06/2007

Multiple roles of the candidate oncogeneZNF217in ovarian epithelial neoplastic progression
International Journal of Cancer
Peixiang Li, Sarah Maines-Bandiera, Wen-Lin Kuo, Yinghui Guan, Yu Sun, Mark Hills, Guiqing Huang, Collin C. Collins, Peter C.K. Leung, Joe W. Gray, Nelly Auersperg
DOI: 10.1002/ijc.22300
05/2007

Involvement of NF-¿B subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II geneDifferential regulation of the GnRH II gene
FEBS Journal
Ruby L. C. Hoo, Kathy Y. Y. Chan, Francis K. Y. Leung, Leo T. O. Lee, Peter C. K. Leung, Billy K. C. Chow
DOI: 10.1111/j.1742-4658.2007.05804.x
04/2007

Role of endocrine and growth factors on the ovarian surface epithelium.
The journal of obstetrics and gynaecology research
DOI: 10.1111/j.1447-0756.2007.00478.x
PubMed: 17212660
02/2007

Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines.
Human reproduction (Oxford, England)
DOI: 10.1093/humrep/del356
PubMed: 17067994
01/2007

Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma.
BMC medicine
DOI: 10.1186/1741-7015-5-33
PubMed: 18005407
2007

Immunolocalization of Gonadotropin-Releasing Hormone (GnRH)-I, GnRH-II, and Type I GnRH Receptor during Follicular Development in the Human Ovary
The Journal of Clinical Endocrinology & Metabolism
Jung-Hye Choi, C. Blake Gilks, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/jc.2006-1147
11/2006

Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9.
Cancer research
DOI: 10.1158/0008-5472.can-06-2217
PubMed: 17108127
11/2006

Endocrine signaling in ovarian surface epithelium and cancer
Human Reproduction Update
Jung-Hye Choi, Peter C.K. Leung
DOI: 10.1093/humupd/dml002
10/2006

Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid by gonadotropins in human immortalized ovarian surface epithelium and ovarian cancer cells.
Endocrine-related cancer
DOI: 10.1677/erc.1.01057
PubMed: 16728589
06/2006

Differential effects of interleukin-1ß and transforming growth factor-ß1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro
Human Reproduction
York Hunt Ng, Hua Zhu, Catherine J. Pallen, Peter C.K. Leung, Colin D. MacCalman
DOI: 10.1093/humrep/del108
05/2006

Steroid Receptor Coactivator-3 Is Required for Progesterone Receptor Trans-activation of Target Genes in Response to Gonadotropin-releasing Hormone Treatment of Pituitary Cells
Journal of Biological Chemistry
Beum-Soo An, David M. Selva, Geoffrey L. Hammond, Adolfo Rivero-Muller, Nafis Rahman, Peter C. K. Leung
DOI: 10.1074/jbc.m600743200
05/2006

Gonadotropins Activate Proteolysis and Increase Invasion through Protein Kinase A and Phosphatidylinositol 3-Kinase Pathways in Human Epithelial Ovarian Cancer Cells
Cancer Research
Jung-Hye Choi, Kyung-Chul Choi, Nelly Auersperg, Peter C.K. Leung
DOI: 10.1158/0008-5472.can-05-1785
04/2006

Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway.
Endocrine-related cancer
DOI: 10.1677/erc.1.01033
PubMed: 16601289
03/2006

Cell type- and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: possible role of GDF-9.
Differentiation; research in biological diversity
DOI: 10.1111/j.1432-0436.2006.00053.x
PubMed: 16466395
02/2006

Impact of Environmental Endocrine Disruption on the Reproductive System for Human Health
Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry
Kyung-Chul Choi, Eui-Bae Jeung, Peter Leung
DOI: 10.2174/187152206775528905
02/2006

Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-4-49
PubMed: 17010207
2006

Regulation of A Disintegrin And Metalloproteinase with ThromboSpondin Repeats-1 Expression in Human Endometrial Stromal Cells by Gonadal Steroids Involves Progestins, Androgens, and Estrogens
The Journal of Clinical Endocrinology & Metabolism
Jiadi Wen, Hua Zhu, Shuko Murakami, Peter C. K. Leung, Colin D. MacCalman
DOI: 10.1210/jc.2006-1567
2006

Biology and physiology of Calbindin-D9k in female reproductive tissues: involvement of steroids and endocrine disruptors.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-3-66
PubMed: 16288660
11/2005

Expression and transcriptional regulation of the GnRH receptor gene in human neuronal cells.
Molecular human reproduction
DOI: 10.1093/molehr/gah241
PubMed: 16364974
11/2005

Caspase-1a Is Down-regulated in Human Ovarian Cancer Cells and the Overexpression of Caspase-1a Induces Apoptosis
Cancer Research
Qiang Feng, Peixiang Li, Clara Salamanca, David Huntsman, Peter C.K. Leung, Nelly Auersperg
DOI: 10.1158/0008-5472.can-05-0239
10/2005

GnRH in non-hypothalamic reproductive tissues
Animal Reproduction Science
N. Ramakrishnappa, R. Rajamahendran, Yung-Ming Lin, P.C.K. Leung
DOI: 10.1016/j.anireprosci.2005.05.009
08/2005

Gonadotropins upregulate the epidermal growth factor receptor through activation of mitogen-activated protein kinases and phosphatidyl-inositol-3-kinase in human ovarian surface epithelial cells.
Endocrine-related cancer
DOI: 10.1677/erc.1.00896
PubMed: 15947112
06/2005

Molecular Biology of Gonadotropin-Releasing Hormone (GnRH)-I, GnRH-II, and Their Receptors in Humans
Endocrine Reviews
Chi Keung Cheng, Peter C. K. Leung
DOI: 10.1210/er.2003-0039
04/2005

Extracellular Signal-Regulated Protein Kinase, But Not c-Jun N-Terminal Kinase, Is Activated by Type II Gonadotropin-Releasing Hormone Involved in the Inhibition of Ovarian Cancer Cell Proliferation
The Journal of Clinical Endocrinology & Metabolism
Ki-Yon Kim, Kyung-Chul Choi, Se-Hyung Park, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/jc.2004-1636
03/2005

Differential Role of Progesterone Receptor Isoforms in the Transcriptional Regulation of Human Gonadotropin-Releasing Hormone I (GnRH I) Receptor, GnRH I, and GnRH II
The Journal of Clinical Endocrinology & Metabolism
Beum-Soo An, Jung-Hye Choi, Kyung-Chul Choi, Peter C. K. Leung
DOI: 10.1210/jc.2004-0318
02/2005

Expression of Leptin Receptors and Potential Effects of Leptin on the Cell Growth and Activation of Mitogen-Activated Protein Kinases in Ovarian Cancer Cells
The Journal of Clinical Endocrinology & Metabolism
Jung-Hye Choi, Se-Hyung Park, Peter C. K. Leung, Kyung-Chul Choi
DOI: 10.1210/jc.2004-0297
01/2005

Extrapituitary effects of GnRH and analogs: evidence and importance
Medicine Therapeutique en Endocrinologie de la Reproduction
2005

Overexpression of Follicle-Stimulating Hormone Receptor Activates Oncogenic Pathways in Preneoplastic Ovarian Surface Epithelial Cells
The Journal of Clinical Endocrinology & Metabolism
Jung-Hye Choi, Kyung-Chul Choi, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/jc.2004-0044
11/2004

Adenosine 5'-Triphosphate Activates Nuclear Translocation of Mitogen-Activated Protein Kinases Leading to the Induction of Early Growth Response 1 and Raf Expression in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
Chen-Jei Tai, Shu-Ju Chang, Peter C. K. Leung, Chii-Ruey Tzeng
DOI: 10.1210/jc.2003-032111
10/2004

Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
Journal of Obstetrics and Gynaecology Research
Akiko Fuchisawa, Stephan van Eeden, Laura A. Magee, Beth Whalen, Peter C. K. Leung, James A. Russell, Keith R. Walley, Peter von Dadelszen
DOI: 10.1111/j.1447-0756.2004.00209.x
10/2004

Caspase-1zeta, a new splice variant of the caspase-1 gene.
Genomics
DOI: 10.1016/j.ygeno.2004.06.005
PubMed: 15498465
09/2004

Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.
Experimental cell research
DOI: 10.1016/j.yexcr.2004.06.002
PubMed: 15302591
09/2004

Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat model
Reproductive Toxicology
Eui-Ju Hong, Kyung-Chul Choi, Yong-Woo Jung, Peter C.K Leung, Eui-Bae Jeung
DOI: 10.1016/j.reprotox.2004.03.005
07/2004

Activin Receptor Signaling
Growth Factors
DOI: 10.1080/08977190410001704688
06/2004

Type II Gonadotropin-Releasing Hormone Stimulates p38 Mitogen-Activated Protein Kinase and Apoptosis in Ovarian Cancer Cells
The Journal of Clinical Endocrinology & Metabolism
Ki-Yon Kim, Kyung-Chul Choi, Se-Hyung Park, Chun-Shan Chou, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/jc.2003-031871
06/2004

Oviductal glycoprotein, a new differentiation-based indicator present in early ovarian epithelial neoplasia and cortical inclusion cysts.
Gynecologic oncology
DOI: 10.1016/j.ygyno.2004.01.047
PubMed: 15099939
05/2004

Effects of Epidermal Growth Factor/Hydrocortisone on the Growth and Differentiation of Human Ovarian Surface Epithelium
Journal of the Society for Gynecologic Investigation
Clara M. Salamanca, Sarah L. Maines-Bandiera, Peter C. K. Leung, Yu-Long Hu, Nelly Auersperg
DOI: 10.1016/j.jsgi.2003.10.010
05/2004

Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line.
Differentiation; research in biological diversity
DOI: 10.1111/j.1432-0436.2004.07204003.x
PubMed: 15157238
04/2004

Cellular Localization of Gonadotropin-Releasing Hormone (GnRH) I and GnRH II in First-Trimester Human Placenta and Decidua
The Journal of Clinical Endocrinology & Metabolism
Chun-Shan Chou, Alexander G. Beristain, Colin D. MacCalman, Peter C. K. Leung
DOI: 10.1210/jc.2003-031636
03/2004

Complex regulation of Calbindin-D9k in the mouse placenta and extra-embryonic membrane during mid- and late pregnancy
Molecular and Cellular Endocrinology
Beum-Soo An, Kyung-Chul Choi, Geun-Shik Lee, Peter C.K. Leung, Eui-Bae Jeung
DOI: 10.1016/j.mce.2003.11.029
02/2004

Gn-RH as an Autocrine Regulator in the Human Ovary
The Ovary, Second Edition
DOI: 10.1016/b978-012444562-8/50018-5
2004

Gain of OGP, an Estrogen-Regulated Oviduct-Specific Glycoprotein, Is Associated with the Development of Endometrial Hyperplasia and Endometrial Cancer
Clinical Cancer Research
M. M. M. Woo
DOI: 10.1158/1078-0432.ccr-04-1261
2004

Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-1-71
PubMed: 14577832
10/2003

Regulatory Effects of Gonadotropin-Releasing Hormone (GnRH) I and GnRH II on the Levels of Matrix Metalloproteinase (MMP)-2, MMP-9, and Tissue Inhibitor of Metalloproteinases-1 in Primary Cultures of Human Extravillous Cytotrophoblasts
The Journal of Clinical Endocrinology & Metabolism
Chun-Shan Chou, Hua Zhu, Colin D. MacCalman, Peter C. K. Leung
DOI: 10.1210/jc.2003-030659
10/2003

Transcriptional regulation of the mouse calbindin-D9k gene by the ovarian sex hormone.
Molecules and cells
PubMed: 14503844
08/2003

Differential Effects of Gonadotropin-Releasing Hormone I and II on the Urokinase-Type Plasminogen Activator/Plasminogen Activator Inhibitor System in Human Decidual Stromal Cellsin Vitro
The Journal of Clinical Endocrinology & Metabolism
Chun-Shan Chou, Colin D. MacCalman, Peter C. K. Leung
DOI: 10.1210/jc.2002-021955
08/2003

Functional Cooperation between Multiple Regulatory Elements in the Untranslated Exon 1 Stimulates the Basal Transcription of the Human GnRH-II Gene
Molecular Endocrinology
Chi Keung Cheng, Ruby L. C. Hoo, Billy K. C. Chow, Peter C. K. Leung
DOI: 10.1210/me.2002-0418
07/2003

Potential role of gonadotrophin-releasing hormone (GnRH)-I and GnRH-II in the ovary and ovarian cancer.
Endocrine-related cancer
DOI: 10.1677/erc.0.0100169
PubMed: 12790779
06/2003

Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.
Biology of reproduction
DOI: 10.1095/biolreprod.102.013045
PubMed: 12606401
05/2003

Multi-factorial role of GnRH-I and GnRH-II in the human ovary
Molecular and Cellular Endocrinology
Peter C.K. Leung, Chi Keung Cheng, Xiao-Ming Zhu
DOI: 10.1016/s0303-7207(03)00076-5
04/2003

Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-1-29
PubMed: 12702211
03/2003

Differential Regulation of Gonadotropin-Releasing Hormone (GnRH)I and GnRHII Messenger Ribonucleic Acid by Gonadal Steroids in Human Granulosa Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
Shahram Khosravi, Peter C. K. Leung
DOI: 10.1210/jc.2002-020866
02/2003

Two Inr Elements Are Important for Mediating the Activity of the Proximal Promoter of the Human Gonadotropin-Releasing Hormone Receptor Gene
Endocrinology
DOI: 10.1210/en.2002-220591
02/2003

Dose-Dependent Effects of Gonadotropin Releasing Hormone on Matrix Metalloproteinase (MMP)-2, and MMP-9 and Tissue Specific Inhibitor of Metalloproteinases-1 Messenger Ribonucleic Acid Levels in Human Decidual Stromal Cells in Vitro
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jc.2002-021277
02/2003

Gonadotropin-Releasing Hormone And Reproductive Medicine
Journal of Obstetrics and Gynaecology Canada
Eliezer Shalev, Peter C.K. Leung
DOI: 10.1016/s1701-2163(16)30206-7
02/2003

Adenosine triphosphate activates mitogen-activated protein kinase in pre-neoplastic and neoplastic ovarian surface epithelial cells.
Biology of reproduction
DOI: 10.1095/biolreprod.102.006551
PubMed: 12493727
01/2003

Activin Receptor Signaling
Encyclopedia of Hormones
Peter C.K. Leung, Chun Peng
DOI: 10.1016/b0-12-341103-3/00004-8
2003

An Activator Protein 1-Like Motif Mediates 17ß-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor a-Dependent Mechanism in Ovarian and Breast Cancer Cells
Molecular Endocrinology
Chi Keung Cheng, Billy K. C. Chow, Peter C. K. Leung
DOI: 10.1210/me.2003-0217
2003

Differential effects of cellular fibronectin and plasma fibronectin on ovarian cancer cell adhesion, migration, and invasion.
In vitro cellular & developmental biology. Animal
DOI: 10.1007/s11626-003-0013-0
PubMed: 14505428
2003

Oncogenic pathways of mitogen-activated protein kinases and phosphatidylinositol 3-kinase in epithelial ovarian cancer
Korean Journal of Gynecologic Oncology and Colposcopy
2003

Effects of gonadotropin-releasing hormone (GnRH)-I and -II on regulating the urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in cultured human extravillous cytotrophoblasts
Fertility and Sterility
Chunshan Sam Chou, Eliezer Shalev, Hua Ellen Zhu, Colin D MacCalman, Peter C.K Leung
DOI: 10.1016/s0015-0282(02)03650-6
09/2002

Adenosine triphosphate induces activation of caspase in apoptosis of human granulosa-luteal cells
Fertility and Sterility
Chen-Jei Tai, Shu-Ju Chang, Peter C.K Leung, Chii-Ruey Tzeng
DOI: 10.1016/s0015-0282(02)03831-1
09/2002

Human Chorionic Gonadotropin-Activated cAMP Pathway Regulates Human Placental GnRH Receptor Gene Transcription in Choriocarcinoma JEG-3 Cells
The Journal of Clinical Endocrinology & Metabolism
Kwai Wa Cheng, Peter C. K. Leung
DOI: 10.1210/jcem.87.7.8650
07/2002

Characterization of a new upstream GnRH receptor promoter in human ovarian granulosa-luteal cells.
Molecular Endocrinology
DOI: 10.1210/me.16.7.1552
PubMed: 12089350
07/2002

Intracellular Calcium Mobilization in Response to the Activation of Human Wild-Type and Chimeric Gonadotropin Receptors
Endocrinology
Pearly S. N. Lee, Alison M. J. Buchan, Aaron J. W. Hsueh, Basil Ho Yuen, Peter C. K. Leung
DOI: 10.1210/endo.143.5.8758
05/2002

Follicle-Stimulating Hormone Activates Mitogen-Activated Protein Kinase in Preneoplastic and Neoplastic Ovarian Surface Epithelial Cells
The Journal of Clinical Endocrinology & Metabolism
Kyung-Chul Choi, Sung Keun Kang, Chen-Jei Tai, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/jcem.87.5.8506
05/2002

Oct-1 Is Involved in the Transcriptional Repression of the Gonadotropin-Releasing Hormone Receptor Gene
Endocrinology
Chi Keung Cheng, Chung Man Yeung, Ruby L. C. Hoo, Billy K. C. Chow, Peter C. K. Leung
DOI: 10.1210/en.2002-220576
2002

Direct Action of Melatonin in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
Michelle M. M. Woo, Chen-Jei Tai, Sung Keun Kang, Parimal S. Nathwani, Shiu Fun Pang, Peter C. K. Leung
DOI: 10.1210/jcem.86.10.7912
10/2001

Expression and Antiproliferative Effect of a Second Form of Gonadotropin-Releasing Hormone in Normal and Neoplastic Ovarian Surface Epithelial Cells
The Journal of Clinical Endocrinology & Metabolism
Kyung-Chul Choi, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/jcem.86.10.8100
10/2001

Profiling of Protein Kinases in the Neoplastic Transformation of Human Ovarian Surface Epithelium
Gynecologic Oncology
Alice S.T. Wong, Sung O. Kim, Peter C.K. Leung, Nelly Auersperg, Steven L. Pelech
DOI: 10.1006/gyno.2001.6280
08/2001

Antigonadotropic Action of Adenosine Triphosphate in Human Granulosa-Luteal Cells: Involvement of Protein Kinase Ca
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.86.7.7691
07/2001

Human gonadotropin-releasing hormone receptor gene transcription: up-regulation by 3',5'-cyclic adenosine monophosphate/protein kinase A pathway
Molecular and Cellular Endocrinology
Kwai Wa Cheng, Peter C.K. Leung
DOI: 10.1016/s0303-7207(01)00480-4
07/2001

Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells.
Endocrinology
DOI: 10.1210/en.142.6.2351
PubMed: 11356682
06/2001

Interplay of pituitary adenylate cyclase-activating polypeptide with a silencer element to regulate the upstream promoter of the human gonadotropin-releasing hormone receptor gene
Molecular and Cellular Endocrinology
Elly S.W. Ngan, Peter C.K. Leung, Billy K.C. Chow
DOI: 10.1016/s0303-7207(01)00402-6
05/2001

The Regulation of Apoptosis by Activin and Transforming Growth Factor-ß in Early Neoplastic and Tumorigenic Ovarian Surface Epithelium1
The Journal of Clinical Endocrinology & Metabolism
Kyung-Chul Choi, Sung Keun Kang, Chen-Jei Tai, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/jcem.86.5.7478
05/2001

Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology
Endocrine Reviews
DOI: 10.1210/edrv.22.2.0422
04/2001

Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells.
Endocrinology
DOI: 10.1210/en.142.4.1554
PubMed: 11250936
04/2001

Functional Mapping of a Placenta-Specific Upstream Promoter for Human Gonadotropin-Releasing Hormone Receptor Gene1
Endocrinology
Kwai Wa Cheng, Billy K. C. Chow, Peter C. K. Leung
DOI: 10.1210/endo.142.4.8104
04/2001

Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE)
Molecular and Cellular Endocrinology
Kyung-Chul Choi, Sung Keun Kang, Parimal S. Nathwani, Kwai Wa Cheng, Nelly Auersperg, Peter C.K. Leung
DOI: 10.1016/s0303-7207(00)00447-0
03/2001

Coexpression of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis?
Oncogene
DOI: 10.1038/sj.onc.1204253
PubMed: 11313876
03/2001

Stimulation of Mitogen-Activated Protein Kinase by Gonadotropin-Releasing Hormone in Human Granulosa-Luteal Cells
Endocrinology
DOI: 10.1210/endo.142.2.7960
02/2001

Adenosine Triphosphate-Evoked Cytosolic Calcium Oscillations in Human Granulosa-Luteal Cells: Role of Protein Kinase C1
The Journal of Clinical Endocrinology & Metabolism
Chen-Jei Tai, Sung Keun Kang, Peter C. K. Leung
DOI: 10.1210/jcem.86.2.7231
02/2001

Estradiol Regulates Gonadotropin-Releasing Hormone (GnRH) and its Receptor Gene Expression and Antagonizes the Growth Inhibitory Effects of GnRH in Human Ovarian Surface Epithelial and Ovarian Cancer Cells
Endocrinology
DOI: 10.1210/endo.142.2.7982
02/2001

Role of Mitogen-Activated Protein Kinase in Prostaglandin F2aAction in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.86.1.7159
01/2001

Differential Regulation of Two Forms of Gonadotropin-Releasing Hormone Messenger Ribonucleic Acid in Human Granulosa-Luteal Cells1
Endocrinology
Sung Keun Kang, Chen-Jei Tai, Parimal S. Nathwani, Peter C. K. Leung
DOI: 10.1210/endo.142.1.7895
01/2001

Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates
International Journal of Oncology
H. Lau, Xiao-Ming Zhu, Peter Leung, L. Chan, G. Chen, Peter Chan, K. Yu, Franky Chan
DOI: 10.3892/ijo.19.6.1193
2001

DIFFERENTIATION AND GROWTH POTENTIAL OF HUMAN OVARIAN SURFACE EPITHELIAL CELLS EXPRESSING TEMPERATURE-SENSITIVE SV40 T ANTIGEN
In Vitro Cellular & Developmental Biology - Animal
EARNEST H. L. LEUNG, PETER C. K. LEUNG, NELLY AUERSPERG
DOI: 10.1290/1071-2690(2001)0372.0.co;2
2001

Interaction of prostaglandin F(2alpha) and prostaglandin E(2) on progesterone production in human granulosa-luteal cells.
Biological signals and receptors
PubMed: 11721093
2001

Hormonal Regulation of Estrogen Receptor a and ß Gene Expression in Human Granulosa-Luteal Cellsin Vitro
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.85.10.6886
10/2000

Transcriptional Down-Regulation of Human Gonadotropin-Releasing Hormone (GnRH) Receptor Gene by GnRH: Role of Protein Kinase C and Activating Protein 1
Endocrinology
DOI: 10.1210/endo.141.10.7730
10/2000

Hepatocyte growth factor promotes in vitro scattering and morphogenesis of human cervical carcinoma cells.
Gynecologic oncology
DOI: 10.1006/gyno.2000.5877
PubMed: 10926796
08/2000

Regulation of Human Gonadotropin-Releasing Hormone Receptor Gene Expression in Placental Cells
Endocrinology
DOI: 10.1210/endo.141.7.7543
07/2000

Regulation of Gonadotropin-Releasing Hormone and Its Receptor Gene Expression by 17ß-Estradiol in Cultured Human Granulosa-Luteal Cells1
Endocrinology
Parimal S. Nathwani, Sung Keun Kang, Kwai Wa Cheng, Kyung-Chul Choi, Peter C. K. Leung
DOI: 10.1210/endo.141.5.7447
05/2000

Expression and Regulation of P2U-Purinergic Receptor in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.85.4.6558
04/2000

Differential expression of human gonadotropin-releasing hormone receptor gene in pituitary and ovarian cells
Molecular and Cellular Endocrinology
Sung Keun Kang, Kwai Wa Cheng, Elly S.W. Ngan, Billy K.C. Chow, Kyung-Chul Choi, Peter C.K. Leung
DOI: 10.1016/s0303-7207(00)00196-9
04/2000

Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma.
British journal of cancer
DOI: 10.1054/bjoc.1999.1127
PubMed: 10780520
04/2000

Identification of an Upstream Promoter in the Human Gonadotropin-Releasing Hormone Receptor Gene
Biochemical and Biophysical Research Communications
Elly S.W. Ngan, Peter C.K. Leung, Billy K.C. Chow
DOI: 10.1006/bbrc.2000.2509
04/2000

Role of Gonadotropin-Releasing Hormone as an Autocrine Growth Factor in Human Ovarian Surface Epithelium1
Endocrinology
Sung Keun Kang, Kyung-Chul Choi, Kwai Wa Cheng, Parimal S. Nathwani, Nelly Auersperg, Peter C. K. Leung
DOI: 10.1210/endo.141.1.7250
01/2000

Gonadotropin-releasing hormone activates mitogen-activated protein kinase in human ovarian and placental cells
Molecular and Cellular Endocrinology
Sung Keun Kang, Chen-Jei Tai, Kwai Wa Cheng, Peter C.K Leung
DOI: 10.1016/s0303-7207(00)00320-8
2000

Autocrine Role of Gonadotropin-Releasing Hormone and Its Receptor in Ovarian Cancer Cell Growth
Endocrine
Sung K. Kang, Kwai W. Cheng, Parimal S. Nathwani, Kyung-Chul Choi, Peter C. K. Leung
DOI: 10.1385/endo:13:3:297
2000

Extrapituitary gonadotropin-releasing hormone (GnRH) receptor
Hormone Frontier in Gynecology
2000

The expression, regulation and signal transduction pathways of the mammalian gonadotropin-releasing hormone receptor
Canadian Journal of Physiology and Pharmacology
Kwai Wa Cheng, Peter CK Leung
DOI: 10.1139/y00-096
2000

Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression
Endocrinology
DOI: 10.1210/endo.140.6.6759
06/1999

Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: Influence of family history of ovarian cancer
International Journal of Cancer
Alice S.T. Wong, Sarah L. Maines-Bandiera, Barry Rosen, Margaret J. Wheelock, Keith R. Johnson, Peter C.K. Leung, Calvin D. Roskelley, Nelly Auersperg
DOI: 10.1002/(sici)1097-0215(19990412)81:23.0.co;2-7
04/1999

Human Peripheral Blood Mononuclear Cells Express Gonadotropin-Releasing Hormone (GnRH), GnRH Receptor, and Interleukin-2 Receptor ¿-Chain Messenger Ribonucleic Acids That Are Regulated by GnRHin Vitro1
The Journal of Clinical Endocrinology & Metabolism
Hsin-Fu Chen, Eui-Bae Jeung, Mary Stephenson, Peter C. K. Leung
DOI: 10.1210/jcem.84.2.5440
02/1999

Human ovary and placenta express messenger RNA for multiple activin receptors
Life Sciences
Chun Peng, Tsukasa Ohno, Loo Yee Koh, Victor T.S. Chen, Peter C.K. Leung
DOI: 10.1016/s0024-3205(99)00035-1
02/1999

Cell survival effect of activin against heat shock stress on OVCAR3
Life Sciences
Jun Fukuda, Ikuro Ito, Toshinobu Tanaka, Peter C.K. Leung
DOI: 10.1016/s0024-3205(98)00505-0
11/1998

Metaplastic changes in cultured human ovarian surface epithelium.
In vitro cellular & developmental biology. Animal
DOI: 10.1007/s11626-998-0059-0
PubMed: 9794215
10/1998

Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway.
Endocrine
DOI: 10.1385/endo:8:3:301
PubMed: 9741835
06/1998

Regulation of prostaglandin F2alpha-receptor mRNA in human granulosa-luteal cells by human chorionic gonadotrophin and prostaglandin F2alpha.
Endocrine
DOI: 10.1385/endo:8:3:261
PubMed: 9741831
06/1998

Expression of the messenger RNA for gonadotropin-releasing hormone and its receptor in human cancer cell lines
Life Sciences
Hong Yin, Kwai Wa Cheng, Hsiao-Lin Hwa, Chun Peng, Nelly Auersperg, Peter C.K. Leung
DOI: 10.1016/s0024-3205(98)00173-8
04/1998

Interaction of prostaglandin F2alpha and gonadotropin-releasing hormone on progesterone and estradiol production in human granulosa-luteal cells.
Biology of reproduction
DOI: 10.1095/biolreprod57.6.1346
PubMed: 9408239
12/1997

Efficient introduction of genes into human ovarian surface epithelium
In Vitro Cellular & Developmental Biology - Animal
Earnest H. Leung, Barry R. Davies, Peter C. K. Leung, George T. C. Chen, Calvin D. Roskelley, Nelly Auersperg
DOI: 10.1007/s11626-997-0120-4
09/1997

Mechanisms involved in ATP-evoked Ca2+ oscillations in isolated human granulosa-luteal cells.
Cell calcium
DOI: 10.1016/s0143-4160(97)90030-0
PubMed: 9174649
05/1997

Characterization and regulation of a mRNA encoding the prostaglandin F2alpha receptor in the rat ovary.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(96)03894-4
PubMed: 8912810
10/1996

P2-purinoreceptor evoked changes in intracellular calcium oscillations in single isolated human granulosa-lutein cells.
Endocrinology
P S Lee, P E Squires, A M Buchan, B H Yuen, P C Leung
DOI: 10.1210/endo.137.9.8756543
09/1996

Long-term growth and steroidogenic potential of human granulosa-lutein cells immortalized with SV40 large T antigen
Molecular and Cellular Endocrinology
Byong-Lyul Lie, Earnest Leung, Peter C.K. Leung, Nelly Auersperg
DOI: 10.1016/0303-7207(96)03835-x
07/1996

Quantitation of activin receptor type-I mRNA by competitive PCR in human trophoblast cells
Placenta
Victor Chen, Jessica Dy, Chun Peng, Peter C.K. Leung
DOI: 10.1016/s0143-4004(96)90203-9
07/1996

Molecular characterisation of the gonadotropin-releasing hormone receptor gene
Animal Reproduction Science
Peter C.K. Leung, Nancy C. Fan, Chun Peng
DOI: 10.1016/0378-4320(96)01482-0
04/1996

Gonadotropin-Releasing Hormone Receptor: Gene Structure, Expression and Regulation
Neurosignals
Peter C.K. Leung, Chun Peng
DOI: 10.1159/000109175
1996

Prostaglandins and Their Receptors: Implications for Ovarian Physiology
Neurosignals
Jan I. Olofsson, Peter C.K. Leung
DOI: 10.1159/000109178
1996

Activin and Follistatin as Local Regulators in the Human Ovary
Neurosignals
Chun Peng, Tsukasa Ohno, Shideh Khorasheh, Peter C.K. Leung
DOI: 10.1159/000109177
1996

Purinoreceptor-mediated calcium signalling in isolated human granulosa-lutein cells
Endocrinology
1996

Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization.
Mammalian genome : official journal of the International Mammalian Genome Society
DOI: 10.1007/bf00352431
PubMed: 7613048
04/1995

The baboon expresses the calbindin-D9k gene in intestine but not in uterus and placenta: Implication for conservation of the gene in primates
Molecular Reproduction and Development
Eui-Bae Jeung, Nancy C. Fan, Peter C. K. Leung, John C. Herr, Alex Freemerman, John Krisinger
DOI: 10.1002/mrd.1080400403
04/1995

Homologous and heterologous regulation of gonadotropin-releasing hormone receptor gene expression in preovulatory rat granulosa cells.
Endocrinology
J I Olofsson, C C Conti, P C Leung
DOI: 10.1210/endo.136.3.7867607
03/1995

The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals
Molecular and Cellular Endocrinology
Nancy C Fan, Chun Peng, John Krisinger, Peter C.K Leung
DOI: 10.1016/0303-7207(94)03460-b
02/1995

Porcine Calbindin-D9k Gene: Expression in Endometrium, Myometrium, and Placenta in the Absence of a Functional Estrogen Response Element in Intron A
Biology of Reproduction
DOI: 10.1095/biolreprod52.1.115
01/1995

Expression and regulation of gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acids in human granulosa-luteal cells.
Endocrinology
DOI: 10.1210/endo.135.5.7956897
PubMed: 7956897
11/1994

The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(94)90087-6
PubMed: 7958384
07/1994

Expression of calbindin-D9k in the early pregnant rat uterus: Effects of RU 486 and correlation to estrogen receptor mRNA
Molecular and Cellular Endocrinology
John Krisinger, Takuya Setoyama, Peter C.K. Leung
DOI: 10.1016/0303-7207(94)90092-2
06/1994

Auto/paracrine role of prostaglandins in corpus luteum function
Molecular and Cellular Endocrinology
Jan Olofsson, Peter C.K. Leung
DOI: 10.1016/0303-7207(94)90284-4
04/1994

The Human Calbindin-D9k Gene
Journal of Molecular Biology
Eui-Bae Jeung, Peter C.K. Leung, John Krisinger
DOI: 10.1006/jmbi.1994.1076
01/1994

Gonadotropin-releasing hormone (GnRH) and cyclic amp positively regulate inhibin subunit messenger RNA levels in human placental cells
Life Sciences
Wei Li, Jan I. Olofsson, Eui-Bae Jeung, John Krisinger, Basil Ho Yuen, Peter C.K. Leung
DOI: 10.1016/0024-3205(94)00340-8
01/1994

Tissue-specific regulation of gonadotropin-releasing hormone (GnRH) receptor gene expression during the periovulatory period
Endocrine
1994

Expression of the type II activin receptor gene in the human placenta.
Endocrinology
DOI: 10.1210/en.133.6.3046
PubMed: 8243335
12/1993

Cytosolic free Ca2+ in human syncytiotrophoblast cells increased by gonadotropin-releasing hormone
Endocrinology
W. D. Currie
DOI: 10.1210/en.133.5.2220
11/1993

Calbindin-D9k gene expression during the perinatal period in the rat: correlation to estrogen receptor expression in uterus
Molecular and Cellular Endocrinology
John Krisinger, Jamie L. Dann, Oliver Applegarth, W.David Currie, Eui-Bae Jeung, Michael Staun, Peter C.K. Leung
DOI: 10.1016/0303-7207(93)90211-2
11/1993

Acute stimulation of human chorionic gonadotropin secretion by recombinant human activin-A in first trimester human trophoblast.
Endocrinology
DOI: 10.1210/endo.133.1.8319577
PubMed: 8319577
07/1993

Stimulation of progesterone secretion by recombinant follistatin-288 in human granulosa cells.
Endocrinology
DOI: 10.1210/endo.132.4.8384994
PubMed: 8384994
04/1993

Arachidonic acid and cell signalling in the ovary and placenta.
Prostaglandins, leukotrienes, and essential fatty acids
DOI: 10.1016/0952-3278(93)90013-m
PubMed: 8424126
01/1993

Signal Transduction of PGF2a in Rat Corpora Lutea
Molecular Basis of Reproductive Endocrinology
Gillian L. Steele, Peter C. K. Leung
DOI: 10.1007/978-1-4613-9260-6_21
1993

Mechanism of prostaglandin F2 alpha action in the ovary.
Journal of lipid mediators
PubMed: 8358010
1993

Arachidonic Acid as a Second Messenger for Regulation of Aromatase Activity in Porcine Granulosa Cells
Molecular Basis of Reproductive Endocrinology
F. Ledwitz-Rigby, M. K. Nickerson, S. W. Lin, Peter C. K. Leung
DOI: 10.1007/978-1-4613-9260-6_18
1993

LHRH- and (Hydroxyproline9) LHRH-Stimulated hCG Secretion from Perifused First-Trimester Placental Cells
Recent Progress in Hormone Research
W. DAVID CURRIE, GILLIAN L. STEELE, BASIL HO YUEN, CLAUDE KORDON, J.-PIERRE GAUTRON, Peter C.K. Leung
DOI: 10.1016/b978-0-12-571148-7.50026-9
1993

Molecular Basis of Reproductive Endocrinology
DOI: 10.1007/978-1-4613-9260-6
1993

LHRH- and (hydroxyproline9) LHRH-stimulated hCG secretion from perifused first-trimester placental cells.
Recent progress in hormone research
PubMed: 8441858
1993

Characterization of Cell Types within a Chorionic Gonadotropin-Secreting, Mechanically Dissociated Human Placental Cell Population in Perifusion
Neurosignals
Gillian L. Steele, David Currie, Basil Ho Yuen, Peter C.K. Leung
DOI: 10.1159/000109487
1993

GnRH- and cAMP-Stimulated Human Chorionic Gonadotropin Secretion from Perifused Placental Cells
Molecular Basis of Reproductive Endocrinology
W. David Currie, Gillian L. Steele, Basil Ho-Yuen, Peter C. K. Leung
DOI: 10.1007/978-1-4613-9260-6_25
1993

Divergent differentiation of rat adrenocortical cells is associated with an interruption of angiotensin II-mediated signal transduction
Molecular and Cellular Endocrinology
Calvin D Roskelley, Kenneth G Baimbridge, Peter C.K Leung, Nelly Auersperg
DOI: 10.1016/0303-7207(92)90213-p
11/1992

Cloning of the Porcine Calbindin-D9k Complementary Deoxyribonucleic Acid by Anchored Polymerase Chain Reaction Technique1
Biology of Reproduction
Eui-Bae Jeung, John Krisinger, Jamie L. Dann, Peter C. K. Leung
DOI: 10.1095/biolreprod47.4.503
10/1992

Calbindin-D9k gene expression during pregnancy and lactation in the rat
Molecular and Cellular Endocrinology
J. Krisinger, J.L. Dann, E.B. Jeung, P.C.K. Leung
DOI: 10.1016/0303-7207(92)90016-y
10/1992

Rapid stimulation of human chorionic gonadotropin secretion by interleukin-1 beta from perifused first trimester trophoblast.
The Journal of Clinical Endocrinology & Metabolism
G L Steele, W D Currie, E H Leung, B H Yuen, P C Leung
DOI: 10.1210/jcem.75.3.1517367
09/1992

Intracellular calcium and the signaling mechanism of luteinizing hormone—releasing hormone in rat granulosa cells
American Journal of Obstetrics and Gynecology
Jian Wang, Gillian L. Steele, Kenneth G. Baimbridge, Marie R. Rodway, Peter C.K. Leung
DOI: 10.1016/s0002-9378(11)91450-1
08/1992

Intracellular signaling in the gonads.
Endocrine reviews
DOI: 10.1210/er.13.3.476
PubMed: 1425484
08/1992

Molecular cloning of the full-length cDNA encoding the human calbindin-D9k
FEBS Letters
Eui-Bae Jeung, John Krisinger, Jamie L. Dann, Peter C.K. Leung
DOI: 10.1016/0014-5793(92)80772-9
07/1992

Inhibition of progestin accumulation by activin-A in human granulosa cells.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.75.1.285
PubMed: 1320053
07/1992

Calbindin-D9k mRNA is tightly regulated during the estrous cycle in the rat uterus.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(92)90182-6
PubMed: 1511778
07/1992

Cytosolic free calcium increased by prostaglandin F2 alpha (PGF2 alpha), gonadotropin-releasing hormone, and angiotensin II in rat granulosa cells and PGF2 alpha in human granulosa cells.
Endocrinology
DOI: 10.1210/endo.130.4.1547713
PubMed: 1547713
04/1992

Prostaglandin F2a and gonadotropin-releasing hormone increase intracellular free calcium in rat granulosa cells
Molecular and Cellular Endocrinology
Marie R. Rodway, Gillian L. Steele, Kenneth G. Baimbridge, Peter C.K. Leung
DOI: 10.1016/0303-7207(92)90080-p
03/1992

Intragonadal signalling mechanisms in the control of steroid hormone production
The Journal of Steroid Biochemistry and Molecular Biology
Gillian L. Steele, Peter C.K. Leung
DOI: 10.1016/0960-0760(92)90376-t
03/1992

Suppression of Luteinizing Hormone Secretion by Atrial and Brain Natriuretic Peptides in Ovariectomized Rats
Endocrinology
DOI: 10.1210/endo-129-2-801
08/1991

Effect of prostaglandin F2 alpha on cytosolic free calcium ion concentrations in rat luteal cells.
Endocrinology
DOI: 10.1210/endo-129-2-889
PubMed: 1855479
08/1991

Inositol Lipid Metabolism and Calcium Signaling in Rat Ovarian Cells
Signaling Mechanisms and Gene Expression in the Ovary
Marie R. Rodway, Peter C. K. Leung
DOI: 10.1007/978-1-4612-3200-1_3
1991

Androgens Positively Regulate Follicle-Stimulating Hormone ß-Subunit mRNA Levels in Rat Pituitary Cells
Molecular Endocrinology
Soheyla D. Gharib, Peter C. K. Leung, Rona S. Carroll, William W. Chin
DOI: 10.1210/mend-4-11-1620
11/1990

Inhibition of aromatase activity by 8-bromo-cyclic adenosine monophosphate in cultured first-trimester human trophoblast
American Journal of Obstetrics and Gynecology
Marie R Rodway, Basil Ho Yuen, Peter C.K Leung
DOI: 10.1016/0002-9378(90)90623-f
11/1990

The physiological basis of superovulation
Seminars in Reproductive Physiology
1990

Mechanism of action of luteinizing hormone-releasing hormone in rat ovarian cells
Canadian Journal of Physiology and Pharmacology
Peter C. K. Leung, Jian Wang, Kenneth G. Baimbridge
DOI: 10.1139/y89-152
08/1989

Ovarian follicular development and regression
Canadian Journal of Physiology and Pharmacology
Peter C. K. Leung
DOI: 10.1139/y89-149
08/1989

Synergistic stimulation of prostaglandin E2 production by calcium ionophore and protein kinase C activator in rat granulosa cells.
Biology of reproduction
DOI: 10.1095/biolreprod40.5.1000
PubMed: 2504300
05/1989

Changes in Cytosolic Free Calcium Ion Concentrations in Individual Rat Granulosa Cells: Effect of Luteinizing Hormone-Releasing Hormone*
Endocrinology
JIAN WANG, KENNETH G. BAIMBRIDGE, PETER C. K. LEUNG
DOI: 10.1210/endo-124-4-1912
04/1989

Arachidonic Acid as a Stimulatory Mediator of Luteinizing Hormone-Releasing Hormone Action in the Rat Ovary*
Endocrinology
JIAN WANG, PETER C. K. LEUNG
DOI: 10.1210/endo-124-4-1973
04/1989

Differential role of protein kinase C in the action of luteinizing hormone-releasing hormone on hormone production in rat ovarian cells
American Journal of Obstetrics and Gynecology
J. Wang, V. Lee, P.C.K. Leung
DOI: 10.1016/0002-9378(89)90321-9
04/1989

The Role of Inositol Lipid Metabolism in the Ovary
Biology of Reproduction
Peter C. K Leung, Jian Wang
DOI: 10.1095/biolreprod40.4.703
04/1989

Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid.
FEBS letters
DOI: 10.1016/0014-5793(89)81182-2
PubMed: 2494061
02/1989

PERTURBATION OF INTRACELLULAR CALCIUM ION CONCENTRATION IN SINGLE RAT GRANULOSA CELLS BY ANGIOTENSIN II
Endocrinology
JIAN WANG, KENNETH G. BAIMBRIDGE, PETER C.K. LEUNG
DOI: 10.1210/endo-124-2-1094
02/1989

Inositol lipids and LHRH action in the rat ovary.
Journal of reproduction and fertility. Supplement
PubMed: 2509693
1989

Role of Calcium in the Action of LHRH on Ovarian Progesterone Production
Growth Factors and the Ovary
Peter C. K. Leung, Jian Wang
DOI: 10.1007/978-1-4684-5688-2_33
1989

Electrical Stimulation of Ascending Noradrenergic Tracts in the Midbrain: Suppression of Steroid-Induced Luteinizing Hormone Release
Endocrinology
DOI: 10.1210/endo-122-3-899
03/1988

Role of Arachidonic Acid in Luteinizing Hormone-Releasing Hormone Action: Stimulation of Progesterone Production in Rat Granulosa Cells*
Endocrinology
JIAN WANG, PETER C. K. LEUNG
DOI: 10.1210/endo-122-3-906
03/1988

Inhibition of follicle-stimulating hormone- and adenosine-3',5'-cyclic monophosphate-induced progesterone production by calcium and protein kinase C in the rat ovary.
American journal of obstetrics and gynecology
DOI: 10.1016/0002-9378(88)90153-6
PubMed: 2829629
02/1988

Differential effects of 8-bromo-cyclic AMP on human chorionic gonadotropin (hCG), progesterone and estrogen production by term placental cells
Life Sciences
Marie Rodway, Fuzhen Zhou, Joanne Benoit, Basil Ho Yuen, Peter C.K. Leung
DOI: 10.1016/0024-3205(88)90256-1
01/1988

Effects of cyclic adenosine monophosphate on human chorionic gonadotropin and estradiol output by cultured human placental cells
American Journal of Obstetrics and Gynecology
Joanne Benoit, Marie Rodway, Basil Ho Yuen, Peter C.K. Leung
DOI: 10.1016/0002-9378(88)90148-2
1988

Role of testosterone in the regulation of rat ovarian estradiol-17b secretion
Life Science Advances
1988

Role of protein kinase C in luteinizing hormone-releasing hormone (LHRH)-stimulated progesterone production in rat granulosa cells
Biochemical and Biophysical Research Communications
Jian Wang, Peter C.K. Leung
DOI: 10.1016/0006-291x(87)90737-6
08/1987

Luteinizing hormone-releasing hormone (LHRH)-induced arachidonic acid release in rat granulosa cells Role of calcium and protein kinase C
FEBS Letters
T. Minegishi, J. Wang, P.C.K. Leung
DOI: 10.1016/0014-5793(87)80029-7
04/1987

Effects of adenosine 3',5'-cyclic monophosphate, forskolin, and cholera toxin on hormone production in human term placental cells.
American journal of obstetrics and gynecology
DOI: 10.1016/0002-9378(87)90296-1
PubMed: 3030108
02/1987

Electrical Stimulation of Ventral versus Dorsal Mesencephalic Tegmental Areas in the Conscious Rat: Effects on Luteinizing Hormone Release
Neuroendocrinology
Hugo Bergen, Peter C.K. Leung
DOI: 10.1159/000124807
1987

Dual Action of Norepinephrine in the Control of Gonadotropin Release
Endocrinology and Physiology of Reproduction
Hugo Bergen, Peter C. K. Leung
DOI: 10.1007/978-1-4899-1971-7_9
1987

Induction of Polyphosphoinositide Breakdown in Rat Corpus Luteum by Prostaglandin F2a
Endocrinology
DOI: 10.1210/endo-119-1-12
07/1986

Norepinephrine inhibition of pulsatile LH release: receptor specificity.
The American journal of physiology
PubMed: 3953791
02/1986

Alleviation of Estrogen-Induced Hyperprolactinemia through Intracerebral Transplantation of Hypothalamic Tissue Containing Dopaminergic Neurons
Neuroendocrinology
Gary W. Arendash, Peter C.K. Leung
DOI: 10.1159/000124551
1986

Suppression of Progesterone-Induced Gonadotropin Surge by Adrenergic Agonists in Estrogen-Primed Ovariectomized Rats
Neuroendocrinology
Hugo Bergen, Peter C.K. Leung
DOI: 10.1159/000124555
1986

Effects of cannabinoids on progesterone release in cultures of rat luteal cells
Life Sciences
Peter C.K. Leung, Michael Flesher, Young S. Moon, Takashi Minegishi
DOI: 10.1016/0024-3205(85)90296-6
11/1985

Luteinizing Hormone-Releasing Hormone Stimulates Arachidonic Acid Release in Rat Granulosa Cells
Endocrinology
DOI: 10.1210/endo-117-5-2001
11/1985

Luteinizing hormone-releasing hormone enhances polyphosphoinositide breakdown in rat granulosa cells
Biochemical and Biophysical Research Communications
Felix Ma, Peter C.K. Leung
DOI: 10.1016/0006-291x(85)91742-5
08/1985

Effects of prostaglandins and luteinizing hormone-releasing hormone on phosphatidic acid – phosphatidylinositol labeling in rat granulosa cells
Canadian Journal of Physiology and Pharmacology
Takashi Minegishi, Peter C. K. Leung
DOI: 10.1139/y85-058
04/1985

Mechanisms of gonadotropin-releasing hormone and prostaglandin action on luteal cells
Canadian Journal of Physiology and Pharmacology
Peter C. K. Leung
DOI: 10.1139/y85-046
03/1985

Vasopressin rapidly stimulates phosphatidic acid-phosphatidylinositol turnover in rat anterior pituitary cells.
FEBS letters
DOI: 10.1016/0014-5793(85)81183-2
PubMed: 3972124
03/1985

LHRH rapidly stimulates phosphatidylinositol metabolism in enriched gonadotrophs
Molecular and Cellular Endocrinology
Vincent Raymond, Peter C.K. Leung, Raymonde Veilleux, Gérard Lefèvre, Fernand Labrie
DOI: 10.1016/0303-7207(84)90031-5
07/1984

Stimulation by prostaglandin F2 alpha of phosphatidic acid-phosphatidylinositol turnover in rat luteal cells.
Biochemical and biophysical research communications
DOI: 10.1016/0006-291x(83)90377-7
PubMed: 6357198
10/1983

Androgenic alteration in pathways of C19-steroid metabolism by cultured rat granulosa cells.
Biochemical and biophysical research communications
DOI: 10.1016/0006-291x(83)91090-2
PubMed: 6870903
06/1983

STIMULATION OF PHOSPHATIDIC ACID AND PHOSPHATIDYLINOSITOL LABELING IN LUTEAL CELLS BY LUTEINIZING HORMONE RELEASING HORMONE
Endocrinology
PETER C.K. LEUNG, VINCENT RAYMOND, FERNAND LABRIE
DOI: 10.1210/endo-112-3-1138
03/1983

Mechanism of action of TRH: involvement of the phosphatidylinositol (PI) response in the action of TRH in rat anterior pituitary cells.
Life sciences
DOI: 10.1016/0024-3205(82)90072-8
PubMed: 6819422
12/1982

Differential effects of central adrenoceptor agonists on luteinizing hormone release.
Neuroendocrinology
DOI: 10.1159/000123301
PubMed: 6280093
03/1982

Electrophysiologic correlates of steroid modulation of luteinizing hormone release.
The American journal of physiology
PubMed: 7065175
03/1982

beta-Adrenergic suppression of progesterone-induced luteinizing hormone surge in ovariectomized, estrogen-primed rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
PubMed: 6278508
02/1982

Electrical Stimulation of Mesencephalic Noradrenergic Pathway: Effects on Luteinizing Hormone Levels in Blood of Ovariectomized and Ovariectomized, Steroid-Primed Rats
Endocrinology
DOI: 10.1210/endo-109-3-720
09/1981

Effect of an aromatase inhibitor (4-acetoxy-4-androstene-3,17-dione) on the stimulatory action of luteinizing hormone on estradiol-17 beta synthesis by rat preovulatory follicles in vitro.
Biology of reproduction
DOI: 10.1095/biolreprod25.2.290
PubMed: 7306626
09/1981

Effects of intraventricular norepinephrine on preoptic-anterior hypothalamic electrical activity in the freely-moving rat: modulation by ovarian steroid hormones
Brain Research
Peter C.K. Leung, David I. Whitmoyer, Gary W. Arendash, Charles H. Sawyer
DOI: 10.1016/0006-8993(81)91089-1
1981

Further evidence in support of a short-loop feedback action of estrogen on ovarian androgen production
Life Sciences
Peter C.K. Leung, David T. Armstrong
DOI: 10.1016/0024-3205(80)90190-3
08/1980

Interactions of steroids and gonadotropins in the control of steroidogenesis in the ovarian follicle.
Annual review of physiology
DOI: 10.1146/annurev.ph.42.030180.000443
PubMed: 6773470
1980

A Mechanism for the Intraovarian Inhibitory Action of Estrogen on Androgen Production1
Biology of Reproduction
Peter C. K. Leung, David T. Armstrong
DOI: 10.1095/biolreprod21.4.1035
11/1979

Interactions of Estrogen and Androgen with Gonadotropins on Ovarian Progesterone Production1
Biology of Reproduction
Peter C. K. Leung, Keith M. Henderson, David T. Armstrong
DOI: 10.1095/biolreprod20.4.713
05/1979

Inhibition by estradiol-17 beta of porcine thecal androgen production in vitro.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(79)90101-1
PubMed: 223899
05/1979

Estrogen Treatment of Immature Rats Inhibits Ovarian Androgen Production in Vitro*
Endocrinology
PETER C. K. LEUNG, DAVID T. ARMSTRONG
DOI: 10.1210/endo-104-5-1411
05/1979

Stimulatory action of androgen administration in vivo on ovarian responsiveness to gonadotropins.
Endocrinology
DOI: 10.1210/endo-104-4-1119
PubMed: 220024
04/1979

Testosterone restores ovarian aromatase activity in rats treated with a 17,20-lyase inhibitor
Molecular and Cellular Endocrinology
Yair Katz, Peter C.K. Leung, David T. Armstrong
DOI: 10.1016/0303-7207(79)90056-x
04/1979

Stimulatory action of follicle-stimulating hormone and androgens on the responsiveness of rat granulosa cells to gonadotropins in vitro.
Endocrinology
DOI: 10.1210/endo-104-4-1124
PubMed: 220025
04/1979

Changes with age in aromatization of testosterone in immature female rats.
Biology of reproduction
DOI: 10.1095/biolreprod19.5.1036
PubMed: 743539
12/1978

An intraovarian inhibitory action of estrogen on androgen production in vivo.
Biology of reproduction
DOI: 10.1095/biolreprod19.3.641
PubMed: 719107
10/1978

Uterotrophic effects of testosterone and 5alpha-dihydrotestosterone in intact and ovariectomized immature female rats.
Biology of reproduction
DOI: 10.1095/biolreprod15.1.107
PubMed: 953105
08/1976

The thyroidal response to chronic goitrogenic stimulation and the persistence of effects of early goitrogenic stimulation
Canadian Journal of Physiology and Pharmacology
Peter Leung, B. E. March
DOI: 10.1139/y76-080
08/1976

Effects of alterations in maternal thyroid metabolism on embryonic thyroid development in the chick
Canadian Journal of Physiology and Pharmacology
B. E. March, Peter Leung
DOI: 10.1139/y76-038
06/1976

Potential Role of Gonadotropin-Releasing Hormone and Estrogen in Ovarian Cancer
Hormonal Carcinogenesis IV
Peter C. K. Leung, Kyung-Chul Choi, Nelly Auersperg
DOI: 10.1007/0-387-23761-5_21

Research

Normal and neoplastic ovarian surface epithelium -endocrine and hereditary influences
The epithelial ovarian carcinomas, which comprise over 85% of human ovarian cancers, arise in the ovarian surface epithelium (OSE). The etiology and early events in the progression of these carcinomas are among the least understood of all major human malignancies because there are no appropriate animal models, and because methods to culture OSE have become available only recently. The purpose of this project is to define the molecular mechanisms which underlie the control of normal and neoplastic OSE cell growth, differentiation and expression of indicators of neoplastic progression, by GnRH and other key reproductive hormones. Also, the hormonal response of OSE isolated from overtly normal ovaries of women with and without family histories of ovarian cancer will be examined, in order to define the specific abnormalities in the OSE that lead to a high risk of developing ovarian cancer. The results of this research will be relevant to the development of more efficient chemotherapeutic methods for ovarian cancer treatment.

Function of GnRH in endometrium and placenta
The establishment of a successful pregnancy is dependent on the coordinated development of the implanting embryo and the lining of the uterus (endometrium). To date, the regulatory factors involved in the development of a uterine environment that promotes embryonic implantation and/or the formation of functional placenta remain poorly characterized. In this project, the regulation of GnRH in endometrial and trophoblast cells undergoing differentiation in culture will be examined. A better understanding of the role of GnRH and related hormones in implantation and placentation is likely to reduce the number of couples assigned the frustrating and costly diagnosis of unexplained infertility.

Endocrine control of reproduction
The aim of this project is to better understand the hormonal control of reproductive function by GnRH. Experiments are designed to test the hypothesis that, in addition to its well-known role in the regulation of pituitary hormone secretion, GnRH is also an autocrine regulator of ovarian hormone production. Further experiments are proposed to examine the regulation of the human GnRH receptor, at the level of gene transcription. It is expected that this research will lead to a better understanding on the cellular and molecular basis underlying the use of GnRH analogs in many different areas of reproductive medicine, such as fertility and sterility, control of ovulation and assisted reproductive technology.

Grants

CIHR Operating Grant - Project: "Regulation of human ovarian granulosa cell function by GDF9 and BMP15"

Honours & Awards

Distinguished Scholar of the Michael Smith Foundation for Health Research - 2001-present

UBC Killam Research Award - 2009

Honorary Professor of the Institute of Zoology, Chinese Academy of Sciences, Beijing - 2002-present

Research Group Members

Hsun Ming (William) Chang, Postdoctoral Fellow
Hongjin (George) Zhao, Doctoral Student
Christian Klausen, Research Associate
Faten Ahmed, PhD student
Hui Li, Postdoctoral Fellow
Hua (Ellen) Zhu
Yingtao (Stella) Liu, Visiting Scientist
Arezoo Alemzadeh Mehrizi, Doctoral student
Chang Liu, Graduate Student
Yuyin Yi, PhD student
Fuxin Wang
Beili Chen, Graduate Student
Bhavi Pinesh Modi, Postdoctoral Fellow
Jiamin Xie
Liping Zheng