Peter C.K. Leung

Investigator, BC Children's Hospital

Academic Affiliations

Professor, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia

Research Theme

Healthy Starts

Research Group

Pathways to Healthy Birth

Research Areas

Assisted Reproductive Technology

Contact

peter.leung@ubc.ca

Phone

(604) 875-2718

Mailing Address

4500 Oak St
Vancouver, BC
V6H 3N1

Overview: Gonadotropin-releasing hormone (GnRH) is a key regulator of mammalian reproduction. After its release from the hypothalamus, this decapeptide hormone is transported from the brain via the portal blood circulation to the anterior pituitary gland, where it stimulates the synthesis and release of the gonadotropins that play pivotal roles in the regulation of the gonads (i.e. ovary and testis). In addition, GnRH has been implicated as an autocrine regulator in several extra-pituitary tissues, including the ovary and placenta, but the specific functions are still unknown. Numerous synthetic analogs of GnRH are now being used in different areas of reproductive medicine, such as assisted reproduction. The long-term goal of my research program is to understand the multi-faceted role of GnRH in reproductive health and medicine.
Publications: Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy
Human Reproduction Update
DOI: 10.1093/humupd/dmad031
2024
Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome
Journal of Assisted Reproduction and Genetics
DOI: 10.1007/s10815-023-02972-z
2024
EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells
Journal of Ovarian Research
DOI: 10.1186/s13048-024-01404-5
2024
Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms
Developmental Cell
DOI: 10.1016/j.devcel.2024.01.023
2024
Bone Morphogenetic Protein 6 Induces Downregulation of Pentraxin 3 Expression in Human Granulosa Cells through the SMAD-Dependent Signaling Pathway in Women with Polycystic Ovary Syndrome
Research Square
DOI: 10.21203/rs.3.rs-2547203/v1
2023
ID3 mediates BMP2-induced downregulation of ICAM1 expression in human endometiral stromal cells and decidual cells
Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2023.1090593
2023
Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications
Collagen and leather
DOI: 10.1186/s42825-023-00142-6
2023
Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells
FASEB Journal
DOI: 10.1096/fj.202300740R
2023
ANGPTL4 inhibits granulosa cell proliferation in polycystic ovary syndrome by EGFR/JAK1/STAT3-mediated induction of p21
FASEB Journal
DOI: 10.1096/fj.202201246RR
2023
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells
ACS Applied Materials and Interfaces
DOI: 10.1021/acsami.2c18734
2023
Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia
Journal of Translational Medicine
DOI: 10.1186/s12967-023-04472-1
2023
Editorial: Polycystic ovary syndrome: mechanism and management—volume II
Frontiers in Endocrinology
DOI: 10.3389/fendo.2023.1247679
2023
Betacellulin regulates gap junction intercellular communication by inducing the phosphorylation of connexin 43 in human granulosa-lutein cells
Research Square
DOI: 10.21203/rs.3.rs-2499915/v1
2023
NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
Experimental Cell Research
DOI: 10.1016/j.yexcr.2023.113693
2023
BMP2 suppresses the production of pentraxin 3 in human endometrial stromal and decidual stromal cells
The FASEB Journal
Yu Zhang and Hsun-Ming Chang and Hua Zhu and Peter C. K. Leung
DOI: 10.1096/fj.202200081RR
05/2022
Myostatin increases human trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 signaling
Biology of Reproduction
Abdelhafez, F. and Klausen, C. and Zhu, H. and Leung, P.C.K.
DOI: 10.1093/biolre/ioab238
2022
Single-cell assessment of trophoblast stem cell-based organoids as human placenta-modeling platforms
bioRxiv
DOI: 10.1101/2022.11.02.514970
2022
Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing
Research Square
DOI: 10.21203/rs.3.rs-1276715/v2
2022
Impact of growth hormone-releasing hormone antagonist on decidual stromal cell growth and apoptosis in vitro
Biology of Reproduction
DOI: 10.1093/biolre/ioab214
2022
Editorial: Polycystic ovary syndrome (PCOS): Mechanism and management
Frontiers in Endocrinology
DOI: 10.3389/fendo.2022.1030353
2022
Characterization of the roles of amphiregulin and transforming growth factor ß1 in microvasculature-like formation in human granulosa-lutein cells
Frontiers in Cell and Developmental Biology
Li, H. and Chang, H.-M. and Li, S. and Klausen, C. and Shi, Z. and Leung, P.C.K.
DOI: 10.3389/fcell.2022.968166
2022
Activin A promotes hyaluronan production and upregulates versican expression in human granulosa cells
Biology of Reproduction
Tian, S. and Zhang, H. and Chang, H.-M. and Klausen, C. and Huang, H.-F. and Jin, M. and Leung, P.C.K.
DOI: 10.1093/biolre/ioac070
2022
The interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
Biology of Reproduction
Li, S.-J. and Chang, H.-M. and Wang, J.H. and Yang, J. and Leung, P.C.K.
DOI: 10.1093/biolre/ioac020
2022
Primary specification of blastocyst trophectoderm by scRNA-seq: New insights into embryo implantation
Science Advances
DOI: 10.1126/sciadv.abj3725
2022
Transcription factor SOX4 facilitates BMP2-regulated gene expression during invasive trophoblast differentiation
The FASEB Journal
Yuyin Yi and Hua Zhu and Christian Klausen and Peter C. K. Leung
DOI: 10.1096/fj.202100925RR
12/2021
Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells
Reproductive Biology and Endocrinology
Xiaoyan Luo and Hsun-Ming Chang and Yuyin Yi and Yingpu Sun and Peter C. K. Leung
DOI: 10.1186/s12958-021-00854-6
11/2021
BMP6 increases CD68 expression by up-regulating CTGF expression in human granulosa-lutein cells
Molecular and Cellular Endocrinology
Xin-Yue Zhang and Hsun-Ming Chang and Yuyin Yi and Hua Zhu and Rui-Zhi Liu and Peter C.K. Leung
DOI: 10.1016/j.mce.2021.111414
10/2021
Bone morphogenetic protein 2 upregulates SERPINE2 expression through noncanonical SMAD2/3 and p38 MAPK signaling pathways in human granulosa-lutein cells
The FASEB Journal
Xiaoyan Luo and Hsun-Ming Chang and Yuyin Yi and Peter C. K. Leung and Yingpu Sun
DOI: 10.1096/fj.202100670RR
09/2021
Outcomes comparison of IVF/ICSI among different trigger methods for final oocyte maturation: A systematic review and meta-analysis
The FASEB Journal
Yu Zhang and Xiaoyan Guo and Linjiang Guo and Hsun-Ming Chang and Jing Shu and Peter C. K. Leung
DOI: 10.1096/fj.202100406R
07/2021
lncRNA DDGC participates in premature ovarian insufficiency through regulating RAD51 and WT1
Molecular Therapy - Nucleic Acids
Li, D. and Xu, W. and Wang, X. and Dang, Y. and Xu, L. and Lu, G. and Chan, W.-Y. and Leung, P.C.K. and Zhao, S. and Qin, Y.
DOI: 10.1016/j.omtn.2021.10.015
2021
Recent progress in the treatment of women with diminished ovarian reserve
Gynecology and Obstetrics Clinical Medicine
Yin, J. and Chang, H.-M. and Li, R. and Leung, P.C.K.
DOI: 10.1016/j.gocm.2021.10.004
2021
Dysregulated BMP2 in the Placenta May Contribute to Early-Onset Preeclampsia by Regulating Human Trophoblast Expression of Extracellular Matrix and Adhesion Molecules
Frontiers in Cell and Developmental Biology
Yi, Y. and Zhu, H. and Klausen, C. and Chang, H.-M. and Inkster, A.M. and Terry, J. and Leung, P.C.K.
DOI: 10.3389/fcell.2021.768669
2021
The interleukin 6 trans-signaling increases prostaglandin E₂production in human granulosa cells
Biology of Reproduction
DOI: 10.1093/biolre/ioab128
2021
The BMP2 Signaling Axis Promotes Invasive Differentiation of Human Trophoblasts
Frontiers in Cell and Developmental Biology
You, J. and Wang, W. and Chang, H.-M. and Yi, Y. and Zhao, H. and Zhu, H. and Sun, Y. and Tang, M. and Wang, C. and Sang, Y. and Feng, G. and Cheng, S. and Leung, P.C.K. and Zhu, Y.-M.
DOI: 10.3389/fcell.2021.607332
2021
TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study
Frontiers in Endocrinology
Man, Y. and Zhao, R. and Gao, X. and Liu, Y. and Zhao, S. and Lu, G. and Chan, W.-Y. and Leung, P.C.K. and Bian, Y.
DOI: 10.3389/fendo.2020.615846
2021
Roles of TGF-ß Superfamily Proteins in Extravillous Trophoblast Invasion
Trends in Endocrinology and Metabolism
Li, Y. and Yan, J. and Chang, H.-M. and Chen, Z.-J. and Leung, P.C.K.
DOI: 10.1016/j.tem.2020.12.005
2021
TGF-ß1 inhibits microvascular-like formation by decreasing VCAM1 and ICAM1 via the upregulation of SNAIL in human granulosa cells
Molecular and Cellular Endocrinology
Li, H. and Chang, H.-M. and Lin, Y.-M. and Shi, Z. and Leung, P.C.K.
DOI: 10.1016/j.mce.2021.111395
2021
Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): A multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity
BMJ Open
Wu, Y. and Marc, I. and Bouchard, L. and Ouyang, F. and Luo, Z.-C. and Fan, J. and Dubois, L. and Mâsse, B. and Zhang, J. and Leung, P.C.K. and Liao, X.P. and Herba, C.M. and Booij, L. and Shen, J. and Lewin, A. and Jiang, H. and Wang, L. and Xu, J. and Wu, W. and Sun, W. and Wu, J. and Li, H. and Lei, C. and Kozyrskyj, A. and Semenic, S. and Chaillet, N. and Fortier, I. and Masse, L. and Zhan, J. and Allard, C. and Knoppers, B. and Zawati, M. and Baillargeon, J.-P. and Velez, M.P. and Zhang, H. and Yu, Y. and Yu, W. and Ding, Y. and Vaillancourt, C. and Liu, H. and Tetu, A. and Fang, W. and Zhang, R. and Zhao, X. and Jin, Y. and Liu, X.-M. and Zhang, H. and Chen, Z. and Yang, X. and Hao, Y.-H. and Abdelouahab, N. and Fraser, W. and Huang, H.-F.
DOI: 10.1136/bmjopen-2020-045192
2021
Raman spectroscopy of follicular fluid and plasma with machine-learning algorithms for polycystic ovary syndrome screening
Molecular and Cellular Endocrinology
Zhang, X. and Liang, B. and Zhang, J. and Hao, X. and Xu, X. and Chang, H.-M. and Leung, P.C.K. and Tan, J.
DOI: 10.1016/j.mce.2020.111139
2021
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring
Scientific Reports
Lin, X.-H. and Gao, L. and Tian, S. and Klausen, C. and Guo, M.-X. and Gao, Q. and Liu, M.-E. and Wang, H. and Wu, D.-D. and Zhou, C.-L. and Yang, J. and Meng, Y. and Liu, Y. and Xu, G.-F. and Tan, Y.-J. and Ullah, K. and Zhu, Y.-M. and Fraser, W.D. and Sheng, J.-Z. and Leung, P.C.K. and Muglia, L.J. and Wu, Y.-T. and Huang, H.-F.
DOI: 10.1038/s41598-020-79604-4
2021
A Lancet Commission on 70 years of women's reproductive, maternal, newborn, child, and adolescent health in China
The Lancet
Qiao, J. and Wang, Y. and Li, X. and Jiang, F. and Zhang, Y. and Ma, J. and Song, Y. and Ma, J. and Fu, W. and Pang, R. and Zhu, Z. and Zhang, J. and Qian, X. and Wang, L. and Wu, J. and Chang, H.-M. and Leung, P.C.K. and Mao, M. and Ma, D. and Guo, Y. and Qiu, J. and Liu, L. and Wang, H. and Norman, R.J. and Lawn, J. and Black, R.E. and Ronsmans, C. and Patton, G. and Zhu, J. and Song, L. and Hesketh, T.
DOI: 10.1016/S0140-6736(20)32708-2
2021
Connective tissue growth factor mediates bone Morphogenetic protein 2-induced increase in Hyaluronan production in Luteinized human Granulosa cells
Research Square
DOI: 10.21203/rs.3.rs-1098041/v1
2021
Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma.
Journal of pineal research
Zhang Z and Mu Y and Ding D and Zou W and Li X and Chen B and Leung PC and Chang HM and Zhu Q and Wang K and Xue R and Xu Y and Zou H and Zhou P and Wei Z and Cao Y
DOI: 10.1111/jpi.12707
PubMed: 33274466
12/2020
Activin A increases human trophoblast invasion by upregulating integrin ß1 through ALK4.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhu S and Li Z and Cui L and Ban Y and Leung PCK and Li Y and Ma J
DOI: 10.1096/fj.202001604r
PubMed: 33230889
11/2020
lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1.
Molecular therapy. Nucleic acids
Li D and Wang X and Dang Y and Zhang X and Zhao S and Lu G and Chan WY and Leung PCK and Qin Y
DOI: 10.1016/j.omtn.2020.10.041
PubMed: 33335798
11/2020
GDF8 Promotes the Cell Invasiveness in Human Trophoblasts by Upregulating the Expression of Follistatin-Like 3 Through the ALK5-SMAD2/3 Signaling Pathway.
Frontiers in cell and developmental biology
Xie J and Zhu H and Chang HM and Klausen C and Dong M and Leung PCK
DOI: 10.3389/fcell.2020.573781
PubMed: 33195207
10/2020
Gonadotropin-releasing hormone analogs: Mechanisms of action and clinical applications in female reproduction.
Frontiers in neuroendocrinology
Wu HM and Chang HM and Leung PCK
DOI: 10.1016/j.yfrne.2020.100876
PubMed: 33045257
10/2020
BMP2 increases the production of BDNF through the upregulation of proBDNF and furin expression in human granulosa-lutein cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Bai L and Chang HM and Zhang L and Zhu YM and Leung PCK
DOI: 10.1096/fj.202000940r
PubMed: 33047388
10/2020
The p38 signaling pathway mediates the TGF-ß1-induced increase in type I collagen deposition in human granulosa cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li H and Chang HM and Shi Z and Leung PCK
DOI: 10.1096/fj.202001377r
PubMed: 32996643
09/2020
ALK3-SMAD1/5 Signaling Mediates the BMP2-Induced Decrease in PGE2 Production in Human Endometrial Stromal Cells and Decidual Stromal Cells.
Frontiers in cell and developmental biology
Zhang Y and Zhu H and Chang HM and Leung PCK
DOI: 10.3389/fcell.2020.573028
PubMed: 33043005
09/2020
The regulation of IGFBP3 by BMP2 has a role in human endometrial remodeling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Luo J and Zhu H and Chang HM and Lin YM and Yang J and Leung PCK
DOI: 10.1096/fj.202000508r
PubMed: 32975335
09/2020
Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis.
Fertility and sterility
Zhan H and Peng B and Ma J and Lin K and Xu K and Lin J and Yong PJ and Leung PCK and Bedaiwy MA and Lin J
DOI: 10.1016/j.fertnstert.2020.05.005
PubMed: 32762950
08/2020
NPFF increases fusogenic proteins syncytin 1 and syncytin 2 via GCM1 in first trimester primary human cytotrophoblast cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhu H and Peng B and Klausen C and Yi Y and Li Y and Xiong S and von Dadelszen P and Leung PCK
DOI: 10.1096/fj.201902978r
PubMed: 32501590
06/2020
Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1.
Nucleic acids research
Wang X and Zhang X and Dang Y and Li D and Lu G and Chan WY and Leung PCK and Zhao S and Qin Y and Chen ZJ
DOI: 10.1093/nar/gkaa127
PubMed: 32112110
05/2020
TGF-ß1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome.
Experimental & molecular medicine
Fang L and Li Y and Wang S and Li Y and Chang HM and Yi Y and Yan Y and Thakur A and Leung PCK and Cheng JC and Sun YP
DOI: 10.1038/s12276-020-0396-y
PubMed: 32152452
03/2020
Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis.
Human reproduction update
Zhang Y and Zhang C and Shu J and Guo J and Chang HM and Leung PCK and Sheng JZ and Huang H
DOI: 10.1093/humupd/dmz046
PubMed: 32045470
02/2020
Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity.
Frontiers in cell and developmental biology
Zhou X and Xu B and Zhang D and Jiang X and Chang HM and Leung PCK and Xia X and Zhang A
DOI: 10.3389/fcell.2020.00105
PubMed: 32158757
02/2020
ALK4-SMAD3/4 mediates the effects of activin A on the upregulation of PAI-1 in human granulosa lutein cells.
Molecular and cellular endocrinology
Chen B and Chang HM and Zhang Z and Cao Y and Leung PCK
DOI: 10.1016/j.mce.2020.110731
PubMed: 31982478
01/2020
Transvaginal ovarian drilling followed by controlled ovarian stimulation from the next day improves ovarian response for the poor responders with polycystic ovary syndrome during IVF treatment: a pilot study.
Reproductive Biology and Endocrinology : RB&E
Xu B and Zhou M and Cheng M and Zhang D and Wu X and Si C and Xia L and Xu H and Li J and Chang HM and Leung PCK and Zhang A
DOI: 10.1186/s12958-019-0559-7
PubMed: 31980027
01/2020
TGF-ß1 promotes vitamin D-induced prostaglandin E2 synthesis by upregulating vitamin D receptor expression in human granulosa-lutein cells.
American journal of physiology. Endocrinology and metabolism
Wang F and Chang HM and Yi Y and Lin YM and Li H and Leung PCK
DOI: 10.1152/ajpendo.00361.2019
PubMed: 31961707
01/2020
Bone morphogenetic protein 2 promotes human trophoblast cell invasion and endothelial-like tube formation through ID1-mediated upregulation of IGF binding protein-3.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhao HJ and Klausen C and Zhu H and Chang HM and Li Y and Leung PCK
DOI: 10.1096/fj.201902168rr
PubMed: 31908038
01/2020
TGF-ß1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells
Cells
Jingwen Yin and Hsun-Ming Chang and Yuyin Yi and Yuanqing Yao and Peter C.K. Leung
DOI: 10.3390/cells9010185
01/2020
Corrigendum. Decreased PECAM1-mediated TGF-ß1 expression in the mid-secretory endometrium in women with recurrent implantation failure.
Human reproduction (Oxford, England)
Guo F and Si C and Zhou M and Wang J and Zhang D and Leung PCK and Xu B and Zhang A
DOI: 10.1093/humrep/dez236
PubMed: 31769475
01/2020
Erratum: Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer (Journal of Cell Science (2008) 121 (664-674) DOI: 10.1242/jcs.013029)
Journal of Cell Science
Astanehe, A. and Arenillas, D. and Wasserman, W.W. and Leung, P.C.K. and Dunn, S.E. and Davies, B.R. and Mills, G.B. and Auersperg, N.
DOI: 10.1242/jcs.253260
2020
CCN2 Mediates S1P-Induced Upregulation of COX2 Expression in Human Granulosa-Lutein Cells.
Cells
Hu LL and Chang HM and Yi Y and Liu Y and Taylor EL and Zheng LP and Leung PCK
DOI: 10.3390/cells8111445
PubMed: 31731760
11/2019
Bone morphogenetic protein 2 induces the activation of WNT/ß-catenin signaling and human trophoblast invasion through up-regulating BAMBI.
Cellular signalling
Zhao HJ and Chang HM and Klausen C and Zhu H and Li Y and Leung PCK
DOI: 10.1016/j.cellsig.2019.109489
PubMed: 31786181
11/2019
Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite.
Scientific reports
Zhu Y and Klausen C and Zhou J and Guo X and Zhang Y and Zhu H and Li Z and Cheng JC and Xie S and Yang W and Li Y and Leung PCK
DOI: 10.1038/s41598-019-52108-6
PubMed: 31664127
10/2019
Betacellulin enhances ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling.
Cellular signalling
Zhao J and Klausen C and Yi Y and Cheng JC and Chang HM and Leung PCK
DOI: 10.1016/j.cellsig.2019.109439
PubMed: 31654720
10/2019
TGF-ß1 promotes hyaluronan synthesis by upregulating hyaluronan synthase 2 expression in human granulosa-lutein cells.
Cellular signalling
Wang F and Chang HM and Yi Y and Li H and Leung PCK
DOI: 10.1016/j.cellsig.2019.109392
PubMed: 31437481
08/2019
Bone morphogenetic protein 6 affects cell-cell communication by altering the expression of Connexin43 in human granulosa-lutein cells.
Molecular and cellular endocrinology
Wu HC and Chang HM and Yi Y and Sun ZG and Lin YM and Lian F and Leung PCK
DOI: 10.1016/j.mce.2019.110548
PubMed: 31434001
08/2019
Kisspeptin regulation of human decidual stromal cells motility via FAK-Src intracellular tyrosine kinases.
Human reproduction (Oxford, England)
Wu HM and Huang HY and Soong YK and Leung PCK and Wang HS
DOI: 10.1093/humrep/dez061
PubMed: 31188433
07/2019
ID3 mediates the TGF-ß1-induced suppression of matrix metalloproteinase-1 in human granulosa cells.
The FEBS journal
Li H and Chang HM and Shi Z and Leung PCK
DOI: 10.1111/febs.14964
PubMed: 31215762
06/2019
Identification of potential metabolic biomarkers of polycystic ovary syndrome in follicular fluid by SWATH mass spectrometry.
Reproductive biology and endocrinology : RB&E
Sun Z and Chang HM and Wang A and Song J and Zhang X and Guo J and Leung PCK and Lian F
DOI: 10.1186/s12958-019-0490-y
PubMed: 31186025
06/2019
SMAD-dependent signaling mediates BMP6-induced stimulation of connective tissue growth factor in luteinized human granulosa cells.
Biology of reproduction
Liu S and Chang HM and Yi Y and Yao YQ and Leung PCK
DOI: 10.1093/biolre/ioz108
PubMed: 31210269
06/2019
ALK4-SMAD2/3-SMAD4 signaling mediates the activin A-induced suppression of PTX3 in human granulosa-lutein cells.
Molecular and cellular endocrinology
Liu C and Chang HM and Yi Y and Fang Y and Zhao F and Leung PCK and Yang X
DOI: 10.1016/j.mce.2019.110485
PubMed: 31185247
06/2019
Activin A promotes ovarian cancer cell migration by suppressing E-cadherin expression.
Experimental cell research
Yi Y and Cheng JC and Klausen C and Leung PCK
DOI: 10.1016/j.yexcr.2019.06.016
PubMed: 31229504
06/2019
Lapatinib Inhibits Amphiregulin-induced BeWo Choriocarcinoma Cell Proliferation by Reducing ERK1/2 and AKT Signaling Pathways.
Anticancer research
Pires LV and Yi Y and Cheng JC and Pizzolato LS and Cordero E and Leung PCK and Brum IS
DOI: 10.21873/anticanres.13355
PubMed: 31092430
05/2019
The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.
The Journal of clinical endocrinology and metabolism
Li M and Zhao H and Zhao SG and Wei DM and Zhao YR and Huang T and Muhammad T and Yan L and Gao F and Li L and Lu G and Chan WY and Leung PCK and Dunaif A and Liu HB and Chen ZJ
DOI: 10.1210/jc.2018-00544
PubMed: 30247605
04/2019
Palmitic acid causes insulin resistance in granulosa cells via activation of JNK.
Journal of molecular endocrinology
Xu L and Wang W and Zhang X and Ke H and Qin Y and You L and Li W and Lu G and Chan WY and Leung PCK and Zhao S and Chen ZJ
DOI: 10.1530/jme-18-0214
PubMed: 30913535
03/2019
Neurotrophins and glial cell line-derived neurotrophic factor in the ovary: physiological and pathophysiological implications.
Human reproduction update
Chang HM and Wu HC and Sun ZG and Lian F and Leung PCK
DOI: 10.1093/humupd/dmy047
PubMed: 30608586
03/2019
BMP6 increases TGF-ß1 production by up-regulating furin expression in human granulosa-lutein cells.
Cellular signalling
Zhang XY and Chang HM and Zhu H and Liu RZ and Leung PCK
DOI: 10.1016/j.cellsig.2019.01.002
PubMed: 30633987
01/2019
Cell-Cell Interactions in Ovarian Follicles: Role of TGF-ß Superfamily Members
The Ovary
Hsun-Ming Chang and Yi-Min Zhu and Peter C.K. Leung
DOI: 10.1016/b978-0-12-813209-8.00007-8
2019
Maternal Hyperlipidemia Mediates Elevated Blood Pressure in Offspring Associated with Reprogramming Leptin Levels
SSRN
Lin, X.-H. and Xiong, Y.-M. and Tian, S. and Klausen, C. and Guo, M.-X. and Gao, Q. and Liu, M.-E. and Wang, H. and Gao, L. and Wu, D.-D. and Zhou, C.-L. and Yang, J. and Meng, Y. and Liu, Y. and Xu, G.-F. and Lu, Y.-C. and Tan, Y.-J. and Ullah, K. and Zhu, Y.-M. and Fraser, W.D. and Sheng, J.-Z. and Leung, P.C.K. and Muglia, L.J. and Wu, Y.-T. and Huang, H.-F.
DOI: 10.2139/ssrn.3411710
2019
Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells.
Cellular signalling
Bai L and Chang HM and Zhu YM and Leung PCK
DOI: 10.1016/j.cellsig.2018.10.009
PubMed: 30321593
10/2018
GDNF-Induced Downregulation of miR-145-5p Enhances Human Oocyte Maturation and Cumulus Cell Viability.
The Journal of clinical endocrinology and metabolism
Cui L and Fang L and Mao X and Chang HM and Leung PCK and Ye Y
DOI: 10.1210/jc.2017-02742
PubMed: 29897461
07/2018
Increased AIF-1-mediated TNF-a expression during implantation phase in IVF cycles with GnRH antagonist protocol.
Human reproduction (Oxford, England)
Xu B and Zhou M and Wang J and Zhang D and Guo F and Si C and Leung PCK and Zhang A
DOI: 10.1093/humrep/dey119
PubMed: 29897458
07/2018
Bone Morphogenetic Protein 2 Promotes Human Trophoblast Cell Invasion by Inducing Activin A Production.
Endocrinology
Zhao HJ and Chang HM and Zhu H and Klausen C and Li Y and Leung PCK
DOI: 10.1210/en.2018-00301
PubMed: 29846546
07/2018
miR-106a Increases Granulosa Cell Viability and Is Downregulated in Women With Diminished Ovarian Reserve.
The Journal of clinical endocrinology and metabolism
Hong L and Peng S and Li Y and Fang Y and Wang Q and Klausen C and Yin C and Wang S and Leung PCK and Yang X
DOI: 10.1210/jc.2017-02344
PubMed: 29590425
06/2018
TGF-ß1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2.
Placenta
Yi Y and Cheng JC and Klausen C and Leung PCK
DOI: 10.1016/j.placenta.2018.06.313
PubMed: 30055669
06/2018
Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries.
Biology of reproduction
Lin TT and Chang HM and Hu XL and Leung PCK and Zhu YM
DOI: 10.1093/biolre/ioy029
PubMed: 29409020
05/2018
BMP6 Downregulates GDNF Expression Through SMAD1/5 and ERK1/2 Signaling Pathways in Human Granulosa-Lutein Cells
Endocrinology
Xin-Yue Zhang and Hsun-Ming Chang and Elizabeth L Taylor and Rui-Zhi Liu and Peter C K Leung
DOI: 10.1210/en.2018-00189
05/2018
Activated protein C as disease-modifying therapy in antenatal preeclampsia: An open-label, single arm safety and efficacy trial.
Pregnancy hypertension
von Dadelszen P and Magee LA and Benton SJ and Hu Y and Ansermino JM and Carleton B and Carter C and Douglas MJ and Janssen PA and Lee SK and Leung PCK and Li J and MacNab Y and Payne BA and Russell JA
DOI: 10.1016/j.preghy.2018.05.009
PubMed: 30177038
05/2018
Decreased PECAM1-mediated TGF-ß1 expression in the mid-secretory endometrium in women with recurrent implantation failure.
Human reproduction (Oxford, England)
Guo F and Si C and Zhou M and Wang J and Zhang D and Leung PCK and Xu B and Zhang A
DOI: 10.1093/humrep/dey022
PubMed: 29617817
05/2018
Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling.
Cell death & disease
Zhao HJ and Klausen C and Li Y and Zhu H and Wang YL and Leung PCK
DOI: 10.1038/s41419-017-0230-1
PubMed: 29416020
02/2018
SNAIL Mediates TGF-ß1–Induced Downregulation of Pentraxin 3 Expression in Human Granulosa Cells
Endocrinology
Hui Li and Hsun-Ming Chang and Zhendan Shi and Peter C K Leung
DOI: 10.1210/en.2017-03127
02/2018
Metabolomic Markers of Essential Fatty Acids, Carnitine, and Cholesterol Metabolism in Adults and Adolescents with Phenylketonuria.
The Journal of nutrition
DOI: 10.1093/humupd/dmw039
PubMed: 29490096
02/2018
BMP6 Increases TGF-Beta1 Production by Up-Regulating Furin Expression in Human Granulosa-Lutein Cells
SSRN
Zhang, X.-Y. and Chang, H.-M. and Zhu, H. and Liu, R.-Z. and Leung, P.C.K.
DOI: 10.2139/ssrn.3273159
2018
Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors
Journal of Nutrition
Chang, H.-M. and Qiao, J. and Leung, P.C.K.
DOI: 10.1093/jn/nxx039
2018
Human reproductive and prenatal genetics
Human Reproductive and Prenatal Genetics
DOI: 10.1016/C2016-0-05333-0
2018
Physiological roles of activins in the human ovary
Journal of Bio-X Research
Chang, H.-M. and Leung, P.C.K.
DOI: 10.1097/JBR.0000000000000016
2018
TGF-ß1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation.
Cellular signalling
Cheng JC and Yi Y and Chang HM and Leung PCK
DOI: 10.1016/j.cellsig.2017.12.004
PubMed: 29269046
12/2017
Connective tissue growth factor mediates TGF-ß1-induced low-grade serous ovarian tumor cell apoptosis
Oncotarget
DOI: 10.18632/oncotarget.19626
10/2017
SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells
Cellular Signalling
Long Bai and Hsun-Ming Chang and Jung-Chien Cheng and Christian Klausen and Guiyan Chu and Peter C.K. Leung and Gongshe Yang
DOI: 10.1016/j.cellsig.2017.05.017
09/2017
Lithium chloride inhibits StAR and progesterone production through GSK-3ß and ERK1/2 signaling pathways in human granulosa-lutein cells.
Molecular and cellular endocrinology
DOI: 10.1016/j.mce.2017.08.018
PubMed: 28867214
09/2017
Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome.
Clinica chimica acta; international journal of clinical chemistry
DOI: 10.1016/j.cca.2017.06.013
PubMed: 28624500
08/2017
Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3ß/ß-Catenin Signaling Pathway
Endocrinology
Long Bai and Hsun-Ming Chang and Jung-Chien Cheng and Guiyan Chu and Peter C K Leung and Gongshe Yang
DOI: 10.1210/en.2017-00287
07/2017
TGF-ß1 Inhibits Human Trophoblast Cell Invasion by Upregulating Connective Tissue Growth Factor Expression
Endocrinology
Jung-Chien Cheng and Hsun-Ming Chang and Peter C. K Leung
DOI: 10.1210/en.2017-00536
07/2017
ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells
Endocrinology
Long Bai and Hsun-Ming Chang and Jung-Chien Cheng and Guiyan Chu and Peter C. K Leung and Gongshe Yang
DOI: 10.1210/en.2017-00436
07/2017
TGFß1 induces endometrial cancer cell adhesion and migration by up-regulating integrin avß3 via SMAD-independent MEK-ERK1/2 signaling
Cellular Signalling
Siyuan Xiong and Christian Klausen and Jung-Chien Cheng and Peter C.K. Leung
DOI: 10.1016/j.cellsig.2017.03.010
06/2017
Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling
Oncotarget
Qianlan Fan and Yuan Cheng and Hsun-Ming Chang and Masashi Deguchi and Aaron J. Hsueh and Peter C.K. Leung
DOI: 10.18632/oncotarget.15677
04/2017
Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.
EBioMedicine
DOI: 10.1016/j.ebiom.2017.01.011
PubMed: 28111236
02/2017
Growth hormone-releasing hormone antagonist inhibits the invasiveness of human endometrial cancer cells by down-regulating twist and N-cadherin expression
Oncotarget
Hsien-Ming Wu and Hong-Yuan Huang and Andrew V. Schally and Angel Chao and Hung-Hsueh Chou and Peter C.K. Leung and Hsin-Shih Wang
DOI: 10.18632/oncotarget.13877
01/2017
HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis.
Reproductive sciences (Thousand Oaks, Calif.)
DOI: 10.1177/1933719117732164
PubMed: 28969513
01/2017
Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation
Cellular Signalling
Jianfang Zhao and Christian Klausen and Siyuan Xiong and Jung-Chien Cheng and Hsun-Ming Chang and Peter C.K. Leung
DOI: 10.1016/j.cellsig.2016.07.013
11/2016
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells
Oncotarget
Jung-Chien Cheng and Hsun-Ming Chang and Siyuan Xiong and Wai-Kin So and Peter C. K. Leung
DOI: 10.18632/oncotarget.13162
11/2016
Low Thyroid Hormone in Early Pregnancy Is Associated With an Increased Risk of Gestational Diabetes Mellitus.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2016-1506
PubMed: 27583471
11/2016
Connective tissue growth factor mediates growth differentiation factor 8-induced increase of lysyl oxidase activity in human granulosa-lutein cells
Molecular and Cellular Endocrinology
Hsun-Ming Chang and Ying Fang and Pang-Pin Liu and Jung-Chien Cheng and Xiaokui Yang and Peter C.K. Leung
DOI: 10.1016/j.mce.2016.07.007
10/2016
Activin A upregulates PTGS2 expression and increases PGE2 production in human granulosa-lutein cells
Reproduction
Pang-Pin Liu and Hsun-Ming Chang and Jung-Chien Cheng and Peter C K Leung
DOI: 10.1530/rep-16-0262
09/2016
Activin A-induced increase in LOX activity in human granulosa–lutein cells is mediated by CTGF
Reproduction
Hsun-Ming Chang and Jung-Chien Cheng and Yingtao Liu and Christian Klausen and Congjian Xu and Peter C K Leung
DOI: 10.1530/rep-16-0254
08/2016
TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways
Oncotarget
Siyuan Xiong and Jung-Chien Cheng and Christian Klausen and Jianfang Zhao and Peter C.K. Leung
DOI: 10.18632/oncotarget.11311
08/2016
Sprouty4 mediates amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
DOI: 10.1007/s13277-016-4790-y
PubMed: 26768617
07/2016
Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling
Cellular Signalling
Jung-Chien Cheng and Hsun-Ming Chang and Pang-Pin Liu and Peter C.K. Leung
DOI: 10.1016/j.cellsig.2016.03.006
06/2016
Transforming growth factor-ß1 increases lysyl oxidase expression by downregulating MIR29A in human granulosa lutein cells
Reproduction
Ying Fang and Hsun-Ming Chang and Jung-Chien Cheng and Christian Klausen and Peter C K Leung and Xiaokui Yang
DOI: 10.1530/rep-16-0144
06/2016
Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor are expressed at tubal ectopic pregnancy implantation sites
Fertility and Sterility
Bo Peng and Christian Klausen and Lisa Campbell and Peter C.K. Leung and Andrew W. Horne and Mohamed A. Bedaiwy
DOI: 10.1016/j.fertnstert.2016.02.003
06/2016
Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells.
Molecular and cellular endocrinology
DOI: 10.1016/j.mce.2016.03.016
PubMed: 26992562
06/2016
Betacellulin induces Slug-mediated down-regulation of E-cadherin and cell migration in ovarian cancer cells.
Oncotarget
DOI: 10.18632/oncotarget.7591
PubMed: 27129169
05/2016
Whole exome sequencing in recurrent early pregnancy loss.
Molecular human reproduction
DOI: 10.1093/molehr/gaw008
PubMed: 26826164
05/2016
Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling
Oncotarget
Siyuan Xiong and Christian Klausen and Jung-Chien Cheng and Peter C.K. Leung
DOI: 10.18632/oncotarget.9483
05/2016
Growth differentiation factor 8 suppresses cell proliferation by up-regulating CTGF expression in human granulosa cells
Molecular and Cellular Endocrinology
Hsun-Ming Chang and Hui-Hui Pan and Jung-Chien Cheng and Yi-Min Zhu and Peter C.K. Leung
DOI: 10.1016/j.mce.2015.11.009
02/2016
Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells
Fertility and Sterility
Hsun-Ming Chang and Lanlan Fang and Jung-Chien Cheng and Elizabeth L. Taylor and Ying-Pu Sun and Peter C.K. Leung
DOI: 10.1016/j.fertnstert.2015.10.034
02/2016
EGF-Induced Connexin43 Negatively Regulates Cell Proliferation in Human Ovarian Cancer.
Journal of cellular physiology
DOI: 10.1002/jcp.25058
PubMed: 26031779
01/2016
Bone morphogenetic protein 2 regulates cell–cell communication by down-regulating connexin43 expression in luteinized human granulosa cells
Molecular Human Reproduction
Yan-Ting Wu and Hsun-Ming Chang and He-Feng Huang and Jian-Zhong Sheng and Peter C.K. Leung
DOI: 10.1093/molehr/gaw078
2016
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line.
Current molecular medicine
DOI: 10.2174/1566524016666160225154040
PubMed: 26917260
2016
hCG-induced Sprouty2 mediates amphiregulin-stimulated COX-2/PGE2 up-regulation in human granulosa cells: a potential mechanism for the OHSS.
Scientific reports
DOI: 10.1038/srep31675
PubMed: 27539669
2016
BMP4 and BMP7 Suppress StAR and Progesterone Production via ALK3 and SMAD1/5/8-SMAD4 in Human Granulosa-Lutein Cells
Endocrinology
Han Zhang and Christian Klausen and Hua Zhu and Hsun-Ming Chang and Peter C. K. Leung
DOI: 10.1210/en.2015-1494
11/2015
Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation
Endocrinology
Yan Li and Hua Zhu and Christian Klausen and Bo Peng and Peter C. K. Leung
DOI: 10.1210/en.2015-1228
11/2015
Activin A Increases Human Trophoblast Invasion by Inducing SNAIL-Mediated MMP2 Up-Regulation Through ALK4
The Journal of Clinical Endocrinology & Metabolism
Yan Li and Christian Klausen and Hua Zhu and Peter C. K. Leung
DOI: 10.1210/jc.2015-2134
11/2015
Transforming growth factor-ß stimulates human ovarian cancer cell migration by up-regulating connexin43 expression via Smad2/3 signaling
Cellular Signalling
Xin Qiu and Jung-Chien Cheng and Jianfang Zhao and Hsun-Ming Chang and Peter C.K. Leung
DOI: 10.1016/j.cellsig.2015.07.010
10/2015
Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells.
Molecular and cellular endocrinology
DOI: 10.1016/j.mce.2015.05.016
PubMed: 26001835
09/2015
CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.
Cell death & disease
DOI: 10.1038/cddis.2015.229
PubMed: 26313915
08/2015
Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling
Oncotarget
Siyuan Xiong and Christian Klausen and Jung-Chien Cheng and Hua Zhu and Peter C.K. Leung
DOI: 10.18632/oncotarget.5229
08/2015
Transforming growth factor-ß1 up-regulates connexin43 expression in human granulosa cells
Human Reproduction
Yu-Ching Chen and Hsun-Ming Chang and Jung-Chien Cheng and Horng-Der Tsai and Cheng-Hsuan Wu and Peter C.K. Leung
DOI: 10.1093/humrep/dev175
07/2015
AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion
Endocrinology
Bo Peng and Hua Zhu and Liyang Ma and Yan-ling Wang and Christian Klausen and Peter C. K. Leung
DOI: 10.1210/en.2014-1871
06/2015
TGF-ß1 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways
PLOS ONE
Jung-Chien Cheng and Hsun-Ming Chang and Lanlan Fang and Ying-Pu Sun and Peter C. K. Leung
DOI: 10.1371/journal.pone.0126532
05/2015
Transforming growth factor-a induces human ovarian cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner.
Biochemical and biophysical research communications
DOI: 10.1016/j.bbrc.2015.03.180
PubMed: 25869072
05/2015
Gonadotropin-Releasing Hormone Type II (GnRH-II) Agonist Regulates the Motility of Human Decidual Endometrial Stromal Cells: Possible Effect on Embryo Implantation and Pregnancy
Biology of Reproduction
DOI: 10.1095/biolreprod.114.127324
04/2015
Alternative splicing of the androgen receptor in polycystic ovary syndrome.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1418216112
PubMed: 25825716
04/2015
Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells
Molecular and Cellular Endocrinology
Hsun-Ming Chang and Lanlan Fang and Jung-Chien Cheng and Christian Klausen and Ying-Pu Sun and Peter C.K. Leung
DOI: 10.1016/j.mce.2015.01.036
03/2015
TGF-ß1 up-regulates connexin43 expression: A potential mechanism for human trophoblast cell differentiation
Journal of Cellular Physiology
Jung-Chien Cheng and Hsun-Ming Chang and Lanlan Fang and Ying-Pu Sun and Peter C.K. Leung
DOI: 10.1002/jcp.24902
03/2015
Recombinant BMP4 and BMP7 Downregulate Pentraxin 3 in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang and Jung-Chien Cheng and Lanlan Fang and Xin Qiu and Christian Klausen and Elizabeth L. Taylor and Peter C.K. Leung
DOI: 10.1210/jc.2014-2496
03/2015
Recombinant BMP4 and BMP7 Increase Activin A Production by Up-Regulating Inhibin ßA Subunit and Furin Expression in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang and Jung-Chien Cheng and Christian Klausen and Peter C.K. Leung
DOI: 10.1210/jc.2014-3026
03/2015
EpCAM is up-regulated by EGF via ERK1/2 signaling and suppresses human epithelial ovarian cancer cell migration.
Biochemical and biophysical research communications
DOI: 10.1016/j.bbrc.2014.12.097
PubMed: 25576358
02/2015
Nitric Oxide and cGMP Induce COX-2 Expression and PGE2Production in Human Granulosa Cells Through CREB Signaling Pathway
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang and Hsun-Ming Chang and Jung-Chien Cheng and Peter C. K. Leung and Ying-Pu Sun
DOI: 10.1210/jc.2014-2886
02/2015
Loss of Sprouty2 in human high-grade serous ovarian carcinomas promotes EGF-induced E-cadherin down-regulation and cell invasion.
FEBS letters
DOI: 10.1016/j.febslet.2014.12.012
PubMed: 25533808
01/2015
Gonadotropin-Releasing Hormone Regulates Human Trophoblastic Cell Invasion via TWIST-Induced N-cadherin Expression
The Journal of Clinical Endocrinology & Metabolism
Bo Peng and Hua Zhu and Peter C.K. Leung
DOI: 10.1210/jc.2014-1897
01/2015
GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression
Molecular Human Reproduction
Bo Peng and Hua Zhu and Christian Klausen and Liyang Ma and Yan-ling Wang and Peter C.K. Leung
DOI: 10.1093/molehr/gav070
2015
Functional consequences of copy number variants in miscarriage.
Molecular cytogenetics
DOI: 10.1186/s13039-015-0109-8
PubMed: 25674159
2015
Growth Differentiation Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells
Endocrinology
Lanlan Fang and Hsun-Ming Chang and Jung-Chien Cheng and Yiping Yu and Peter C. K. Leung and Ying-Pu Sun
DOI: 10.1210/en.2015-1461
2015
Activin A, B, and AB Increase Human Trophoblast Cell Invasion by Up-regulating N-Cadherin
The Journal of Clinical Endocrinology & Metabolism
Yan Li and Christian Klausen and Jung-Chien Cheng and Hua Zhu and Peter C. K. Leung
DOI: 10.1210/jc.2014-2118
11/2014
TGF-ß1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang and Hsun-Ming Chang and Jung-Chien Cheng and Peter C. K. Leung and Ying-Pu Sun
DOI: 10.1210/jc.2014-1930
11/2014
Amphiregulin induces human ovarian cancer cell invasion by down-regulating E-cadherin expression.
FEBS letters
DOI: 10.1016/j.febslet.2014.09.017
PubMed: 25261255
11/2014
Effects of Recombinant Activins on Steroidogenesis in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang and Jung-Chien Cheng and Christian Klausen and Elizabeth L. Taylor and Peter C. K. Leung
DOI: 10.1210/jc.2014-1223
10/2014
COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion.
Endocrine-related cancer
DOI: 10.1530/erc-13-0450
PubMed: 24969217
08/2014
TGF-ß1 Induces COX-2 Expression and PGE2 Production in Human Granulosa Cells Through Smad Signaling Pathways
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang and Hsun-Ming Chang and Jung-Chien Cheng and Peter C. K. Leung and Ying-Pu Sun
DOI: 10.1210/jc.2013-4100
07/2014
Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells.
Molecular human reproduction
DOI: 10.1093/molehr/gau001
PubMed: 24413384
05/2014
FOXL2-induced follistatin attenuates activin A-stimulated cell proliferation in human granulosa cell tumors
Biochemical and Biophysical Research Communications
Jung-Chien Cheng and Hsun-Ming Chang and Xin Qiu and Lanlan Fang and Peter C.K. Leung
DOI: 10.1016/j.bbrc.2013.12.010
01/2014
Correction: Fibroblast Growth Factor 2 Induces E-Cadherin Down-Regulation via PI3K/Akt/mTOR and MAPK/ERK Signaling in Ovarian Cancer Cells.
PloS one
Lau M and So W and Leung PCK
12/2013
Transforming growth factor-ß1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein.
The Journal of biological chemistry
DOI: 10.1074/jbc.m113.488866
PubMed: 24106276
11/2013
Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha
Biochemical and Biophysical Research Communications
Yu Zhang and Jung-Chien Cheng and He-Feng Huang and Peter C.K. Leung
DOI: 10.1016/j.bbrc.2013.09.121
11/2013
Gonadal steroids regulate the expression of aggrecanases in human endometrial stromal cellsin vitro
Journal of Cellular and Molecular Medicine
Jiadi Wen and Hua Zhu and Peter C.K. Leung
DOI: 10.1111/jcmm.12110
08/2013
Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2.
BMC cancer
DOI: 10.1186/1471-2407-13-300
PubMed: 23786715
06/2013
HER2 mediates epidermal growth factor-induced down-regulation of E-cadherin in human ovarian cancer cells.
Biochemical and biophysical research communications
DOI: 10.1016/j.bbrc.2013.03.062
PubMed: 23542467
04/2013
Theca-Derived BMP4 and BMP7 Down-Regulate Connexin43 Expression and Decrease Gap Junction Intercellular Communication Activity in Immortalized Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Hsun-Ming Chang and Jung-Chien Cheng and Peter C. K. Leung
DOI: 10.1210/jc.2012-3851
03/2013
Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways.
Molecular human reproduction
DOI: 10.1093/molehr/gas055
PubMed: 23184927
03/2013
Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
Cancer Letters
Jung-Chien Cheng and Christian Klausen and Peter C.K. Leung
DOI: 10.1016/j.canlet.2012.10.029
02/2013
Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells.
Oncogene
DOI: 10.1038/onc.2012.127
PubMed: 22508482
02/2013
Molecular mechanism(s) of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors.
Journal of cellular and molecular medicine
DOI: 10.1111/j.1582-4934.2012.01649.x
PubMed: 23279634
01/2013
Targeting Gonadotropin-releasing Hormone Receptor Inhibits the Early Step of Ovarian Cancer Metastasis by Modulating Tumor-mesothelial Adhesion
Molecular Therapy
Lydia WT Cheung and Susan Yung and Tak-Mao Chan and Peter CK Leung and Alice ST Wong
DOI: 10.1038/mt.2012.187
01/2013
Overexpression of Wild-Type but Not C134W Mutant FOXL2 Enhances GnRH-Induced Cell Apoptosis by Increasing GnRH Receptor Expression in Human Granulosa Cell Tumors
PLoS ONE
Jung-Chien Cheng and Christian Klausen and Peter C. K. Leung
DOI: 10.1371/journal.pone.0055099
01/2013
Fibroblast growth factor 2 induces E-cadherin down-regulation via PI3K/Akt/mTOR and MAPK/ERK signaling in ovarian cancer cells.
PloS one
DOI: 10.1371/journal.pone.0059083
PubMed: 23554977
2013
BMP15 Suppresses Progesterone Production by Down-Regulating StAR via ALK3 in Human Granulosa Cells
Molecular Endocrinology
Hsun-Ming Chang and Jung-Chien Cheng and Christian Klausen and Peter C. K. Leung
DOI: 10.1210/me.2013-1233
2013
EGF-like Growth Factors Induce COX-2–Derived PGE2 Production Through ERK1/2 in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
Lanlan Fang and Jung-Chien Cheng and Hsun-Ming Chang and Ying-Pu Sun and Peter C. K. Leung
DOI: 10.1210/jc.2013-2662
2013
Antimüllerian hormone inhibits follicle-stimulating hormone-induced adenylyl cyclase activation, aromatase expression, and estradiol production in human granulosa-lutein cells
Fertility and Sterility
Chang, H.-M. and Klausen, C. and Leung, P.C.K.
DOI: 10.1016/j.fertnstert.2013.04.019
2013
Epidermal Growth Factor Induces Human Oviductal Epithelial Cell Invasion by Down-Regulating E-Cadherin Expression
The Journal of Clinical Endocrinology & Metabolism
Jung-Chien Cheng and Hsun-Ming Chang and Peter C. K. Leung
DOI: 10.1210/jc.2011-2751
08/2012
A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells.
Journal of molecular medicine (Berlin, Germany)
DOI: 10.1007/s00109-012-0881-4
PubMed: 22349439
08/2012
TGF-Beta Induces Serous Borderline Ovarian Tumor Cell Invasion by Activating EMT but Triggers Apoptosis in Low-Grade Serous Ovarian Carcinoma Cells
PLoS ONE
Jung-Chien Cheng and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1371/journal.pone.0042436
08/2012
The Human Gonadotropin-Inhibitory Hormone Ortholog RFamide-Related Peptide-3 Suppresses Gonadotropin-Induced Progesterone Production in Human Granulosa Cells
Endocrinology
Hajime Oishi and Christian Klausen and George E. Bentley and Tomohiro Osugi and Kazuyoshi Tsutsui and C. Blake Gilks and Tetsu Yano and Peter C. K. Leung
DOI: 10.1210/en.2012-1066
07/2012
Integrin ß1 mediates epithelial growth factor-induced invasion in human ovarian cancer cells
Cancer Letters
Man-Tat Lau and Wai-Kin So and Peter C.K. Leung
DOI: 10.1016/j.canlet.2012.02.028
07/2012
Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia.
Diabetes
DOI: 10.2337/db11-1314
PubMed: 22447856
05/2012
Gonadotropin-Releasing Hormone-I or -II Interacts with IGF-I/Akt But Not Connexin 43 in Human Granulosa Cell Apoptosis
The Journal of Clinical Endocrinology & Metabolism
In-Sun Hong and C. Klausen and Anthony P. Cheung and Peter C. K. Leung
DOI: 10.1210/jc.2011-1229
02/2012
Twist Modulates Human Trophoblastic Cell Invasion via Regulation of N-Cadherin
Endocrinology
York Hunt Ng and Hua Zhu and Peter C. K. Leung
DOI: 10.1210/en.2011-1488
02/2012
Gonadotrophin-releasing hormone antagonist induces apoptosis in human decidual stromal cells: effect on GADD45 and MAPK signaling
Human Reproduction
H.-M. Wu and H.-S. Wang and Y.-K. Soong and H.-Y. Huang and C.-K. Chen and C.-L. Lee and P. C. K. Leung
DOI: 10.1093/humrep/der460
01/2012
The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells
Cancer Letters
Man-Tat Lau and Peter C.K. Leung
DOI: 10.1016/j.canlet.2012.08.016
2012
EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
PloS one
DOI: 10.1371/journal.pone.0034071
PubMed: 22479527
2012
Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells.
Oncogene
DOI: 10.1038/onc.2011.117
PubMed: 21478913
09/2011
Identification of Estrogen Response Element in the Aquaporin-2 Gene That Mediates Estrogen-Induced Cell Migration and Invasion in Human Endometrial Carcinoma
The Journal of Clinical Endocrinology & Metabolism
Li-Bo Zou and Run-Ju Zhang and Ya-Jing Tan and Guo-Lian Ding and Shuai Shi and Dan Zhang and Rong-Huan He and Ai-Xia Liu and Ting-Ting Wang and Peter C. K. Leung and Jian-Zhong Sheng and He-Feng Huang
DOI: 10.1210/jc.2011-0426
09/2011
Wild-Type p53 Attenuates Cancer Cell Motility by Inducing Growth Differentiation Factor-15 Expression
Endocrinology
Jung-Chien Cheng and Hsun-Ming Chang and Peter C. K. Leung
DOI: 10.1210/en.2011-0059
08/2011
Growth Differentiation Factor 9 (GDF9) Suppresses Follistatin and Follistatin-Like 3 Production in Human Granulosa-Lutein Cells
PLoS ONE
Feng-Tao Shi and Anthony P. Cheung and He-Feng Huang and Peter C. K. Leung
DOI: 10.1371/journal.pone.0022866
08/2011
Anti-Mu¨llerian Hormone Inhibits FSH-Induced Adenylyl Cyclase Activation, Aromatase Expression, and Estradiol Production in Human Granulosa-Lutein Cells.
Biology of Reproduction
Hsun Ming Chang and Christian Klausen and Peter C.K. Leung
DOI: 10.1093/biolreprod/85.s1.392
07/2011
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via ß-catenin-Egr1-mediated PTEN expression.
Oncogene
DOI: 10.1038/onc.2011.6
PubMed: 21297666
06/2011
P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin.
Oncogene
DOI: 10.1038/onc.2011.7
PubMed: 21317933
06/2011
Type I collagen down-regulates E-cadherin expression by increasing PI3KCA in cancer cells.
Cancer letters
DOI: 10.1016/j.canlet.2011.02.008
PubMed: 21377268
05/2011
Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?
PloS one
DOI: 10.1371/journal.pone.0018473
PubMed: 21494557
04/2011
Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin.
Oncogene
DOI: 10.1038/onc.2010.486
PubMed: 20972462
03/2011
Gonadotropin-Releasing Hormone-II Increases Membrane Type I Metalloproteinase Production via ß-Catenin Signaling in Ovarian Cancer Cells
Endocrinology
Song Ling Poon and Man-Tat Lau and Geoffrey L. Hammond and Peter C. K. Leung
DOI: 10.1210/en.2010-0942
03/2011
Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.2010-2192
PubMed: 21177787
03/2011
37-kDa Laminin Receptor Precursor Mediates GnRH-II–Induced MMP-2 Expression and Invasiveness in Ovarian Cancer Cells
The Journal of Clinical Endocrinology & Metabolism
Song Ling Poon and Christian Klausen and Geoffrey L. Hammond and Peter C. K. Leung
DOI: 10.1210/jcem.96.2.zeg557b
02/2011
Twist Regulates Cadherin-Mediated Differentiation and Fusion of Human Trophoblastic Cells
The Journal of Clinical Endocrinology & Metabolism
York Hunt Ng and Hua Zhu and Peter C. K. Leung
DOI: 10.1210/jc.2010-2714
2011
Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle
Reproductive Biology and Endocrinology
Hyun Yang and Tae-Hee Kim and Hae-Hyeog Lee and Kyung-Chul Choi and Yeon-pyo Hong and Peter CK Leung and Eui-Bae Jeung
DOI: 10.1186/1477-7827-9-28
2011
37-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells
Molecular Endocrinology
Poon, S.L. and Klausen, C. and Hammond, G.L. and Leung, P.C.K.
DOI: 10.1210/me.2010-0334
2011
G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve
Fertility and Sterility
Ting-Ting Wang and Yan-Ting Wu and Min-Yue Dong and Jian-Zhong Sheng and Peter C.K. Leung and He-Feng Huang
DOI: 10.1016/j.fertnstert.2010.03.070
11/2010
Growth Differentiation Factor 9 Reverses Activin A Suppression of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Feng-Tao Shi and Anthony P. Cheung and Christian Klausen and He-Feng Huang and Peter C. K. Leung
DOI: 10.1210/jc.2010-0477
10/2010
Hydrogen Peroxide Mediates EGF-Induced Down-Regulation of E-Cadherin Expression via p38 MAPK and Snail in Human Ovarian Cancer Cells
Molecular Endocrinology
Jung-Chien Cheng and Christian Klausen and Peter C. K. Leung
DOI: 10.1210/me.2010-0034
08/2010
Gonadotropins Induce Tumor Cell Migration and Invasion by Increasing Cyclooxygenases Expression and Prostaglandin E2Production in Human Ovarian Cancer Cells
Endocrinology
Man-Tat Lau and Alice S. T. Wong and Peter C. K. Leung
DOI: 10.1210/en.2009-1318
07/2010
Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer.
Oncogene
DOI: 10.1038/onc.2009.523
PubMed: 20118984
04/2010
Gonadotropin-Releasing Hormone-I-Mediated Activation of Progesterone Receptor Contributes to Gonadotropin a-Subunit Expression in Mouse Gonadotrophs
Endocrinology
Junling Chen and Beum-Soo An and Wai-Kin So and Linan Cheng and Geoffrey L. Hammond and Peter C. K. Leung
DOI: 10.1210/en.2009-0816
03/2010
Influence of the prodrugs 5-fluorocytosine and CPT-11 on ovarian cancer cells using genetically engineered stem cells: tumor-tropic potential and inhibition of ovarian cancer cell growth
Cancer Science
Ki-Yon Kim and Seung U. Kim and Peter C. K. Leung and Eui-Bae Jeung and Kyung-Chul Choi
DOI: 10.1111/j.1349-7006.2009.01485.x
02/2010
Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia.
BJOG : an international journal of obstetrics and gynaecology
DOI: 10.1111/j.1471-0528.2009.02428.x
PubMed: 20002372
01/2010
Oviductal Glycoprotein (OVGP1, MUC9)
International Journal of Gynecological Cancer
Sarah Maines-Bandiera and Michelle M.M. Woo and Marilyn Borugian and Laurie L. Molday and Theresa Hii and Blake Gilks and Peter C.K. Leung and Robert S. Molday and Nelly Auersperg
DOI: 10.1111/igc.0b013e3181bcc96d
01/2010
Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway
Reproductive Biology and Endocrinology
Jian Guo and Andrew V Schally and Marta Zarandi and Jozsef Varga and Peter CK Leung
DOI: 10.1186/1477-7827-8-54
2010
Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells
Reproductive Biology and Endocrinology
Yu Zhang and Qing Huang and Jung-Chien Cheng and Yoshihiro Nishi and Toshihiko Yanase and He-Feng Huang and Peter CK Leung
DOI: 10.1186/1477-7827-8-61
2010
Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth
Carcinogenesis
Jung-Hye Choi and Kyung-Tae Lee and Peter C.K. Leung
DOI: 10.1093/carcin/bgq276
2010
Growth hormone-releasing hormone antagonist induces apoptosis of human endometrial cancer cells through PKCd-mediated activation of p53/p21
Cancer Letters
Hsien-Ming Wu and Andrew V. Schally and Jung-Chien Cheng and Marta Zarandi and Jozsef Varga and Peter C.K. Leung
DOI: 10.1016/j.canlet.2010.05.022
2010
Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-7-144
PubMed: 19968870
12/2009
The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.
PloS one
DOI: 10.1371/journal.pone.0007988
PubMed: 19956657
11/2009
Effects of Endogenous Growth Differentiation Factor 9 on Activin A-Induced Inhibin B Production in Human Granulosa-Lutein Cells.
Molecular endocrinology (Baltimore, Md.)
Shi F and Cheung AP and Huang H and Leung PCK
DOI: 10.1210/mend.23.11.9995
11/2009
Gonadotropin-Releasing Hormone-Mediated Phosphorylation of Estrogen Receptor-a Contributes to fosB Expression in Mouse Gonadotrophs
Endocrinology
DOI: 10.1210/en.2009-0455
10/2009
Cell Motility and Spreading Are Suppressed by HOXA4 in Ovarian Cancer Cells: Possible Involvement of 1 Integrin
Molecular Cancer Research
C. Klausen and P. C.K. Leung and N. Auersperg
DOI: 10.1158/1541-7786.mcr-08-0466
09/2009
Epidermal Growth Factor-Induced GnRH-II Synthesis Contributes to Ovarian Cancer Cell Invasion
The Journal of Clinical Endocrinology & Metabolism
Song Ling Poon and Gareth T. Hammond and Peter C. K. Leung
DOI: 10.1210/jcem.94.9.9996
09/2009
Rapid effect of GNRH1 on follicle-stimulating hormone beta gene expression in LbetaT2 mouse pituitary cells requires the progesterone receptor.
Biology of reproduction
DOI: 10.1095/biolreprod.109.076216
PubMed: 19357364
08/2009
Growth Differentiation Factor 9 Enhances Activin A-Induced Inhibin B Production in Human Granulosa Cells
Endocrinology
Feng-Tao Shi and Anthony P. Cheung and Peter C. K. Leung
DOI: 10.1210/en.2009-0267
08/2009
Clinical and endocrine response to the withdrawal of gonadotropin-releasing hormone agonists during prolonged coasting
Fertility and Sterility
Basil Ho Yuen and Tuan-Anh T. Nguyen and Anthony P. Cheung and Peter C.K. Leung
DOI: 10.1016/j.fertnstert.2008.06.039
08/2009
Promotion of Human Trophoblasts Invasion by Gonadotropin-Releasing Hormone (GnRH) I and GnRH II via Distinct Signaling Pathways
Molecular Endocrinology
Jing Liu and Colin D. MacCalman and Yan-ling Wang and Peter C. K. Leung
DOI: 10.1210/me.2008-0451
07/2009
Mutation of FOXL2 in granulosa-cell tumors of the ovary.
The New England journal of medicine
DOI: 10.1056/nejmoa0902542
PubMed: 19516027
06/2009
Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation.
American journal of physiology. Endocrinology and metabolism
DOI: 10.1152/ajpendo.90929.2008
PubMed: 19366876
06/2009
Gonadotropin-releasing hormone type II induces apoptosis of human endometrial cancer cells by activating GADD45alpha.
Cancer research
DOI: 10.1158/0008-5472.can-08-4591
PubMed: 19366794
05/2009
GnRH signaling in intrauterine tissues.
Reproduction (Cambridge, England)
DOI: 10.1530/rep-08-0397
PubMed: 19208750
05/2009
Gonadotropin-stimulated epidermal growth factor receptor expression in human ovarian surface epithelial cells: involvement of cyclic AMP-dependent exchange protein activated by cAMP pathway.
Endocrine-related cancer
DOI: 10.1677/erc-07-0238
PubMed: 19022848
03/2009
Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells
Differentiation
Takayo Ota and Christian Klausen and M. Clara Salamanca and Henry L. Woo and Peter C.K. Leung and Nelly Auersperg
DOI: 10.1016/j.diff.2008.09.018
02/2009
Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38.
The Journal of reproduction and development
DOI: 10.1262/jrd.20094
PubMed: 18854640
02/2009
Effects of Endogenous Growth Differentiation Factor 9 on Activin A-Induced Inhibin B Production in Human Granulosa-Lutein Cells
The Journal of Clinical Endocrinology & Metabolism
Feng-Tao Shi and Anthony P. Cheung and He-Feng Huang and Peter C. K. Leung
DOI: 10.1210/jc.2009-1047
2009
Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: Involvement of integrin beta3 and focal adhesion kinase
Reproductive Biology and Endocrinology
Dong Park and Kyung-Chul Choi and Colin D MacCalman and Peter CK Leung
DOI: 10.1186/1477-7827-7-81
2009
Leptin interferes with 3',5'-Cyclic Adenosine Monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cells
Reproductive Biology and Endocrinology
Lin, Q. and Poon, S.L. and Chen, J. and Cheng, L. and HoYuen, B. and Leung, P.C.K.
DOI: 10.1186/1477-7827-7-115
2009
Transcripts of testicular gonadotropin-releasing hormone, steroidogenic enzymes, and intratesticular testosterone levels in infertile men
Fertility and Sterility
Yung Ming Lin and Song Ling Poon and Jung Hye Choi and Johnny Shinn Nan Lin and Peter C.K. Leung and Bu Miin Huang
DOI: 10.1016/j.fertnstert.2007.08.078
11/2008
Temporal Recruitment of Transcription Factors at the 3',5'-Cyclic Adenosine 5'-Monophosphate-Response Element of the HumanGnRH-IIPromoter
Endocrinology
Song Ling Poon and Beum-Soo An and Wai-Kin So and Geoffrey L. Hammond and Peter C. K. Leung
DOI: 10.1210/en.2008-0481
10/2008
Gonadotropin-releasing hormone and ovarian cancer: a functional and mechanistic overview
FEBS Journal
Wai-Kin So and Jung-Chien Cheng and Song-Ling Poon and Peter C. K. Leung
DOI: 10.1111/j.1742-4658.2008.06679.x
10/2008
SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells.
Gynecologic oncology
DOI: 10.1016/j.ygyno.2008.06.021
PubMed: 18678400
10/2008
Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha.
Molecular Endocrinology
DOI: 10.1210/me.2007-0512
PubMed: 18550773
09/2008
Gonadotropin-Releasing Hormones I and II Induce Apoptosis in Human Granulosa Cells
The Journal of Clinical Endocrinology & Metabolism
In-Sun Hong and Anthony P. Cheung and Peter C. K. Leung
DOI: 10.1210/jc.2008-0127
08/2008
Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
Journal of cell science
DOI: 10.1242/jcs.013029
PubMed: 18270270
03/2008
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells.
Molecular pharmacology
DOI: 10.1124/mol.107.041087
PubMed: 18042733
03/2008
Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells.
American journal of physiology. Endocrinology and metabolism
DOI: 10.1152/ajpendo.00480.2007
PubMed: 18056793
02/2008
Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
DOI: 10.1111/j.1525-1438.2007.01171.x
PubMed: 18217967
2008
HOX cofactors expression and regulation in the human ovary
Reproductive Biology and Endocrinology
Takayo Ota and Haruka Asahina and Se-Hyung Park and Qing Huang and Takashi Minegishi and Nelly Auersperg and Peter CK Leung
DOI: 10.1186/1477-7827-6-49
2008
HOXA7 in Epithelial Ovarian Cancer: Interrelationships Between Differentiation and Clinical Features
Reproductive Sciences
Takayo Ota and C. Blake Gilks and Teri Longacre and Peter C. K. Leung and Nelly Auersperg
DOI: 10.1177/1933719107307781
09/2007
Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion
Endocrine
Chien-Lin Chen and Lydia W. T. Cheung and Man-Tat Lau and Jung-Hye Choi and Nelly Auersperg and Hsin-Shih Wang and Alice S. T. Wong and Peter C. K. Leung
DOI: 10.1007/s12020-007-0041-8
07/2007
Gonadotropins and Ovarian Cancer
Endocrine Reviews
Jung-Hye Choi and Alice S. T. Wong and He-Feng Huang and Peter C. K. Leung
DOI: 10.1210/er.2006-0036
06/2007
Multiple roles of the candidate oncogeneZNF217in ovarian epithelial neoplastic progression
International Journal of Cancer
Peixiang Li and Sarah Maines-Bandiera and Wen-Lin Kuo and Yinghui Guan and Yu Sun and Mark Hills and Guiqing Huang and Collin C. Collins and Peter C.K. Leung and Joe W. Gray and Nelly Auersperg
DOI: 10.1002/ijc.22300
05/2007
Involvement of NF-¿B subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene
FEBS Journal
Ruby L. C. Hoo and Kathy Y. Y. Chan and Francis K. Y. Leung and Leo T. O. Lee and Peter C. K. Leung and Billy K. C. Chow
DOI: 10.1111/j.1742-4658.2007.05804.x
04/2007
Role of endocrine and growth factors on the ovarian surface epithelium.
The journal of obstetrics and gynaecology research
DOI: 10.1111/j.1447-0756.2007.00478.x
PubMed: 17212660
02/2007
Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines.
Human reproduction (Oxford, England)
DOI: 10.1093/humrep/del356
PubMed: 17067994
01/2007
Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma.
BMC medicine
DOI: 10.1186/1741-7015-5-33
PubMed: 18005407
2007
Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9.
Cancer research
DOI: 10.1158/0008-5472.can-06-2217
PubMed: 17108127
11/2006
Immunolocalization of Gonadotropin-Releasing Hormone (GnRH)-I, GnRH-II, and Type I GnRH Receptor during Follicular Development in the Human Ovary
The Journal of Clinical Endocrinology & Metabolism
Jung-Hye Choi and C. Blake Gilks and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1210/jc.2006-1147
11/2006
Endocrine signaling in ovarian surface epithelium and cancer
Human Reproduction Update
Peter C.K. Leung and Jung-Hye Choi
DOI: 10.1093/humupd/dml002
10/2006
Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid by gonadotropins in human immortalized ovarian surface epithelium and ovarian cancer cells.
Endocrine-related cancer
DOI: 10.1677/erc.1.01057
PubMed: 16728589
06/2006
Steroid Receptor Coactivator-3 Is Required for Progesterone Receptor Trans-activation of Target Genes in Response to Gonadotropin-releasing Hormone Treatment of Pituitary Cells
Journal of Biological Chemistry
Beum-Soo An and David M. Selva and Geoffrey L. Hammond and Adolfo Rivero-Muller and Nafis Rahman and Peter C. K. Leung
DOI: 10.1074/jbc.m600743200
05/2006
Differential effects of interleukin-1ß and transforming growth factor-ß1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro
Human Reproduction
York Hunt Ng and Hua Zhu and Catherine J. Pallen and Peter C.K. Leung and Colin D. MacCalman
DOI: 10.1093/humrep/del108
05/2006
Gonadotropins Activate Proteolysis and Increase Invasion through Protein Kinase A and Phosphatidylinositol 3-Kinase Pathways in Human Epithelial Ovarian Cancer Cells
Cancer Research
Jung-Hye Choi and Kyung-Chul Choi and Nelly Auersperg and Peter C.K. Leung
DOI: 10.1158/0008-5472.can-05-1785
04/2006
Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway.
Endocrine-related cancer
DOI: 10.1677/erc.1.01033
PubMed: 16601289
03/2006
Cell type- and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: possible role of GDF-9.
Differentiation; research in biological diversity
DOI: 10.1111/j.1432-0436.2006.00053.x
PubMed: 16466395
02/2006
Impact of Environmental Endocrine Disruption on the Reproductive System for Human Health
Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry
Kyung-Chul Choi and Eui-Bae Jeung and Peter Leung
DOI: 10.2174/187152206775528905
02/2006
Editorial
Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Leung, P.C.K.
2006
Regulation of A Disintegrin And Metalloproteinase with ThromboSpondin Repeats-1 Expression in Human Endometrial Stromal Cells by Gonadal Steroids Involves Progestins, Androgens, and Estrogens
The Journal of Clinical Endocrinology & Metabolism
Jiadi Wen and Hua Zhu and Shuko Murakami and Peter C. K. Leung and Colin D. MacCalman
DOI: 10.1210/jc.2006-1567
2006
Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-4-49
PubMed: 17010207
2006
Expression and transcriptional regulation of the GnRH receptor gene in human neuronal cells.
Molecular human reproduction
DOI: 10.1093/molehr/gah241
PubMed: 16364974
11/2005
Biology and physiology of Calbindin-D9k in female reproductive tissues: involvement of steroids and endocrine disruptors.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-3-66
PubMed: 16288660
11/2005
Caspase-1a Is Down-regulated in Human Ovarian Cancer Cells and the Overexpression of Caspase-1a Induces Apoptosis
Cancer Research
Qiang Feng and Peixiang Li and Clara Salamanca and David Huntsman and Peter C.K. Leung and Nelly Auersperg
DOI: 10.1158/0008-5472.can-05-0239
10/2005
GnRH in non-hypothalamic reproductive tissues
Animal Reproduction Science
N. Ramakrishnappa and R. Rajamahendran and Yung-Ming Lin and P.C.K. Leung
DOI: 10.1016/j.anireprosci.2005.05.009
08/2005
Gonadotropins upregulate the epidermal growth factor receptor through activation of mitogen-activated protein kinases and phosphatidyl-inositol-3-kinase in human ovarian surface epithelial cells.
Endocrine-related cancer
DOI: 10.1677/erc.1.00896
PubMed: 15947112
06/2005
Molecular Biology of Gonadotropin-Releasing Hormone (GnRH)-I, GnRH-II, and Their Receptors in Humans
Endocrine Reviews
Chi Keung Cheng and Peter C. K. Leung
DOI: 10.1210/er.2003-0039
04/2005
Extracellular Signal-Regulated Protein Kinase, But Not c-Jun N-Terminal Kinase, Is Activated by Type II Gonadotropin-Releasing Hormone Involved in the Inhibition of Ovarian Cancer Cell Proliferation
The Journal of Clinical Endocrinology & Metabolism
Ki-Yon Kim and Kyung-Chul Choi and Se-Hyung Park and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1210/jc.2004-1636
03/2005
Differential Role of Progesterone Receptor Isoforms in the Transcriptional Regulation of Human Gonadotropin-Releasing Hormone I (GnRH I) Receptor, GnRH I, and GnRH II
The Journal of Clinical Endocrinology & Metabolism
Beum-Soo An and Jung-Hye Choi and Kyung-Chul Choi and Peter C. K. Leung
DOI: 10.1210/jc.2004-0318
02/2005
Expression of Leptin Receptors and Potential Effects of Leptin on the Cell Growth and Activation of Mitogen-Activated Protein Kinases in Ovarian Cancer Cells
The Journal of Clinical Endocrinology & Metabolism
Jung-Hye Choi and Se-Hyung Park and Peter C. K. Leung and Kyung-Chul Choi
DOI: 10.1210/jc.2004-0297
01/2005
Adenosine triphosphate induces activation of caspase-3 in apoptosis of human granulosa-luteal cells
Endocrine Journal
Tai, C.-J. and Chang, S.-J. and Chien, L.-Y. and Leung, P.C.K. and Tzeng, C.-R.
DOI: 10.1507/endocrj.52.327
2005
A randomized, double-blind, multicenter study comparing a starting dose of 100 IU or 200 IU of recombinant follicle stimulating hormone (Puregon®) in women undergoing controlled ovarian hyperstimulation for IVF Treatment
Journal of Assisted Reproduction and Genetics
Tan, S.L. and Child, T.J. and Cheung, A.P. and Fluker, M.R. and Yuzpe, A. and Casper, R. and Leung, P. and Cadesky, K. and Davis, V.J.
DOI: 10.1007/s10815-005-1497-1
2005
Erratum: "Adenosine 5'-triphosphate activates nuclear translocation of mitogen-activated protein kinases leading to the induction of early growth response 1 and raf expression in human granulosa-luteal cells (The Journal of Clinical Endocrinology and Metabolism (2004) 89 (5189-5195))
Journal of Clinical Endocrinology and Metabolism
Tai, C.-J. and Chang, S.-J. and Leung, P.C.K. and Tzeng, C.-R.
2005
Extrapituitary effects of GnRH and analogs: evidence and importance
Medicine Therapeutique en Endocrinologie de la Reproduction
2005
Overexpression of Follicle-Stimulating Hormone Receptor Activates Oncogenic Pathways in Preneoplastic Ovarian Surface Epithelial Cells
The Journal of Clinical Endocrinology & Metabolism
Jung-Hye Choi and Kyung-Chul Choi and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1210/jc.2004-0044
11/2004
Adenosine 5'-Triphosphate Activates Nuclear Translocation of Mitogen-Activated Protein Kinases Leading to the Induction of Early Growth Response 1 and Raf Expression in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
Chen-Jei Tai and Shu-Ju Chang and Peter C. K. Leung and Chii-Ruey Tzeng
DOI: 10.1210/jc.2003-032111
10/2004
Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
Journal of Obstetrics and Gynaecology Research
Akiko Fuchisawa and Stephan van Eeden and Laura A. Magee and Beth Whalen and Peter C. K. Leung and James A. Russell and Keith R. Walley and Peter von Dadelszen
DOI: 10.1111/j.1447-0756.2004.00209.x
10/2004
Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.
Experimental cell research
DOI: 10.1016/j.yexcr.2004.06.002
PubMed: 15302591
09/2004
Caspase-1zeta, a new splice variant of the caspase-1 gene.
Genomics
DOI: 10.1016/j.ygeno.2004.06.005
PubMed: 15498465
09/2004
Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat model
Reproductive Toxicology
Eui-Ju Hong and Kyung-Chul Choi and Yong-Woo Jung and Peter C.K Leung and Eui-Bae Jeung
DOI: 10.1016/j.reprotox.2004.03.005
07/2004
Activin Receptor Signaling
Growth Factors
DOI: 10.1016/b0-12-341103-3/00004-8
06/2004
Type II Gonadotropin-Releasing Hormone Stimulates p38 Mitogen-Activated Protein Kinase and Apoptosis in Ovarian Cancer Cells
The Journal of Clinical Endocrinology & Metabolism
Ki-Yon Kim and Kyung-Chul Choi and Se-Hyung Park and Chun-Shan Chou and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1210/jc.2003-031871
06/2004
Mini ReviewActivin Receptor Signaling
Growth Factors
Yumiko Abe and Takashi Minegishi and Peter C.K. Leung
DOI: 10.1080/08977190410001704688
06/2004
Oviductal glycoprotein, a new differentiation-based indicator present in early ovarian epithelial neoplasia and cortical inclusion cysts.
Gynecologic oncology
DOI: 10.1016/j.ygyno.2004.01.047
PubMed: 15099939
05/2004
Effects of Epidermal Growth Factor/Hydrocortisone on the Growth and Differentiation of Human Ovarian Surface Epithelium
Journal of the Society for Gynecologic Investigation
Clara M. Salamanca and Sarah L. Maines-Bandiera and Peter C. K. Leung and Yu-Long Hu and Nelly Auersperg
DOI: 10.1016/j.jsgi.2003.10.010
05/2004
Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line.
Differentiation; research in biological diversity
DOI: 10.1111/j.1432-0436.2004.07204003.x
PubMed: 15157238
04/2004
Cellular Localization of Gonadotropin-Releasing Hormone (GnRH) I and GnRH II in First-Trimester Human Placenta and Decidua
The Journal of Clinical Endocrinology & Metabolism
Chun-Shan Chou and Alexander G. Beristain and Colin D. MacCalman and Peter C. K. Leung
DOI: 10.1210/jc.2003-031636
03/2004
Complex regulation of Calbindin-D9k in the mouse placenta and extra-embryonic membrane during mid- and late pregnancy
Molecular and Cellular Endocrinology
Beum-Soo An and Kyung-Chul Choi and Geun-Shik Lee and Peter C.K. Leung and Eui-Bae Jeung
DOI: 10.1016/j.mce.2003.11.029
02/2004
Gain of OGP, an Estrogen-Regulated Oviduct-Specific Glycoprotein, Is Associated with the Development of Endometrial Hyperplasia and Endometrial Cancer
Clinical Cancer Research
M. M. M. Woo
DOI: 10.1158/1078-0432.ccr-04-1261
2004
Preface
The Ovary: Second Edition
DOI: 10.1016/B978-012444562-8/50001-X
2004
Gn-RH as an Autocrine Regulator in the Human Ovary
The Ovary, Second Edition
DOI: 10.1016/b978-012444562-8/50018-5
2004
Regulatory Effects of Gonadotropin-Releasing Hormone (GnRH) I and GnRH II on the Levels of Matrix Metalloproteinase (MMP)-2, MMP-9, and Tissue Inhibitor of Metalloproteinases-1 in Primary Cultures of Human Extravillous Cytotrophoblasts
The Journal of Clinical Endocrinology & Metabolism
Chun-Shan Chou and Hua Zhu and Colin D. MacCalman and Peter C. K. Leung
DOI: 10.1210/jc.2003-030659
10/2003
Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-1-71
PubMed: 14577832
10/2003
Differential Effects of Gonadotropin-Releasing Hormone I and II on the Urokinase-Type Plasminogen Activator/Plasminogen Activator Inhibitor System in Human Decidual Stromal Cellsin Vitro
The Journal of Clinical Endocrinology & Metabolism
Chun-Shan Chou and Colin D. MacCalman and Peter C. K. Leung
DOI: 10.1210/jc.2002-021955
08/2003
Transcriptional regulation of the mouse calbindin-D9k gene by the ovarian sex hormone.
Molecules and cells
PubMed: 14503844
08/2003
Functional Cooperation between Multiple Regulatory Elements in the Untranslated Exon 1 Stimulates the Basal Transcription of the Human GnRH-II Gene
Molecular Endocrinology
Chi Keung Cheng and Ruby L. C. Hoo and Billy K. C. Chow and Peter C. K. Leung
DOI: 10.1210/me.2002-0418
07/2003
Potential role of gonadotrophin-releasing hormone (GnRH)-I and GnRH-II in the ovary and ovarian cancer.
Endocrine-related cancer
DOI: 10.1677/erc.0.0100169
PubMed: 12790779
06/2003
Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.
Biology of reproduction
DOI: 10.1095/biolreprod.102.013045
PubMed: 12606401
05/2003
Multi-factorial role of GnRH-I and GnRH-II in the human ovary
Molecular and Cellular Endocrinology
Peter C.K. Leung and Chi Keung Cheng and Xiao-Ming Zhu
DOI: 10.1016/s0303-7207(03)00076-5
04/2003
Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
Reproductive biology and endocrinology : RB&E
DOI: 10.1186/1477-7827-1-29
PubMed: 12702211
03/2003
Dose-Dependent Effects of Gonadotropin Releasing Hormone on Matrix Metalloproteinase (MMP)-2, and MMP-9 and Tissue Specific Inhibitor of Metalloproteinases-1 Messenger Ribonucleic Acid Levels in Human Decidual Stromal Cells in Vitro
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jc.2002-021277
02/2003
Gonadotropin-Releasing Hormone And Reproductive Medicine
Journal of Obstetrics and Gynaecology Canada
Eliezer Shalev and Peter C.K. Leung
DOI: 10.1016/s1701-2163(16)30206-7
02/2003
Two Inr Elements Are Important for Mediating the Activity of the Proximal Promoter of the Human Gonadotropin-Releasing Hormone Receptor Gene
Endocrinology
DOI: 10.1210/en.2002-220591
02/2003
Differential Regulation of Gonadotropin-Releasing Hormone (GnRH)I and GnRHII Messenger Ribonucleic Acid by Gonadal Steroids in Human Granulosa Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
Shahram Khosravi and Peter C. K. Leung
DOI: 10.1210/jc.2002-020866
02/2003
Adenosine triphosphate activates mitogen-activated protein kinase in pre-neoplastic and neoplastic ovarian surface epithelial cells.
Biology of reproduction
DOI: 10.1095/biolreprod.102.006551
PubMed: 12493727
01/2003
Transcriptional regulation of the mouse calbindin-D9k gene by the ovarian sex hormone
Molecules and Cells
Lee, K.-Y. and Oh, G.T. and Kang, J.-H. and Shin, S.M. and Heo, B.-E. and Yun, Y.-W. and Paik, S.-G. and Krisinger, J. and Leung, P.C.K. and Jeung, E.-B.
2003
The Ovary: Second Edition
The Ovary: Second Edition
Leung, P.C.K. and Adashi, E.Y.
DOI: 10.1016/B978-0-12-444562-8.X5000-9
2003
Differential effects of cellular fibronectin and plasma fibronectin on ovarian cancer cell adhesion, migration, and invasion.
In vitro cellular & developmental biology. Animal
DOI: 10.1007/s11626-003-0013-0
PubMed: 14505428
2003
Oncogenic pathways of mitogen-activated protein kinases and phosphatidylinositol 3-kinase in epithelial ovarian cancer
Korean Journal of Gynecologic Oncology and Colposcopy
2003
An Activator Protein 1-Like Motif Mediates 17ß-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor a-Dependent Mechanism in Ovarian and Breast Cancer Cells
Molecular Endocrinology
Chi Keung Cheng and Billy K. C. Chow and Peter C. K. Leung
DOI: 10.1210/me.2003-0217
2003
Effects of gonadotropin-releasing hormone (GnRH)-I and -II on regulating the urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in cultured human extravillous cytotrophoblasts
Fertility and Sterility
Chunshan Sam Chou and Eliezer Shalev and Hua Ellen Zhu and Colin D MacCalman and Peter C.K Leung
DOI: 10.1016/s0015-0282(02)03650-6
09/2002
Adenosine triphosphate induces activation of caspase in apoptosis of human granulosa-luteal cells
Fertility and Sterility
Chen-Jei Tai and Shu-Ju Chang and Peter C.K Leung and Chii-Ruey Tzeng
DOI: 10.1016/s0015-0282(02)03831-1
09/2002
Human Chorionic Gonadotropin-Activated cAMP Pathway Regulates Human Placental GnRH Receptor Gene Transcription in Choriocarcinoma JEG-3 Cells
The Journal of Clinical Endocrinology & Metabolism
Kwai Wa Cheng and Peter C. K. Leung
DOI: 10.1210/jcem.87.7.8650
07/2002
Characterization of a new upstream GnRH receptor promoter in human ovarian granulosa-luteal cells.
Molecular Endocrinology
DOI: 10.1210/me.16.7.1552
PubMed: 12089350
07/2002
Follicle-Stimulating Hormone Activates Mitogen-Activated Protein Kinase in Preneoplastic and Neoplastic Ovarian Surface Epithelial Cells
The Journal of Clinical Endocrinology & Metabolism
Kyung-Chul Choi and Sung Keun Kang and Chen-Jei Tai and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1210/jcem.87.5.8506
05/2002
Intracellular Calcium Mobilization in Response to the Activation of Human Wild-Type and Chimeric Gonadotropin Receptors
Endocrinology
Pearly S. N. Lee and Alison M. J. Buchan and Aaron J. W. Hsueh and Basil Ho Yuen and Peter C. K. Leung
DOI: 10.1210/endo.143.5.8758
05/2002
Characterization of a new upstream GnRH receptor promoter in human ovarian granulosa-luteal cells
Molecular Endocrinology
Cheng, C.K. and Yeung, C.M. and Chow, B.K.C. and Leung, P.C.K.
DOI: 10.1210/mend.16.7.0869
2002
Oct-1 Is Involved in the Transcriptional Repression of the Gonadotropin-Releasing Hormone Receptor Gene
Endocrinology
Chi Keung Cheng and Chung Man Yeung and Ruby L. C. Hoo and Billy K. C. Chow and Peter C. K. Leung
DOI: 10.1210/en.2002-220576
2002
The effects of gonadotropin-releasing hormone (GnRH) I and GnRH II on the urokinase-type plasminogen activator/plasminogen activator inhibitor system in human extravillous cytotrophoblasts in vitro
Journal of Clinical Endocrinology and Metabolism
Chou, C.-S. and Zhu, H. and Shalev, E. and MacCalman, C.D. and Leung, P.C.K.
DOI: 10.1210/jc.2002-020883
2002
Expression and Antiproliferative Effect of a Second Form of Gonadotropin-Releasing Hormone in Normal and Neoplastic Ovarian Surface Epithelial Cells
The Journal of Clinical Endocrinology & Metabolism
Kyung-Chul Choi and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1210/jcem.86.10.8100
10/2001
Direct Action of Melatonin in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
Michelle M. M. Woo and Chen-Jei Tai and Sung Keun Kang and Parimal S. Nathwani and Shiu Fun Pang and Peter C. K. Leung
DOI: 10.1210/jcem.86.10.7912
10/2001
Profiling of Protein Kinases in the Neoplastic Transformation of Human Ovarian Surface Epithelium
Gynecologic Oncology
Alice S.T. Wong and Sung O. Kim and Peter C.K. Leung and Nelly Auersperg and Steven L. Pelech
DOI: 10.1006/gyno.2001.6280
08/2001
Human gonadotropin-releasing hormone receptor gene transcription: up-regulation by 3',5'-cyclic adenosine monophosphate/protein kinase A pathway
Molecular and Cellular Endocrinology
Kwai Wa Cheng and Peter C.K. Leung
DOI: 10.1016/s0303-7207(01)00480-4
07/2001
Antigonadotropic Action of Adenosine Triphosphate in Human Granulosa-Luteal Cells: Involvement of Protein Kinase Ca
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.86.7.7691
07/2001
Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells.
Endocrinology
DOI: 10.1210/en.142.6.2351
PubMed: 11356682
06/2001
Interplay of pituitary adenylate cyclase-activating polypeptide with a silencer element to regulate the upstream promoter of the human gonadotropin-releasing hormone receptor gene
Molecular and Cellular Endocrinology
Elly S.W. Ngan and Peter C.K. Leung and Billy K.C. Chow
DOI: 10.1016/s0303-7207(01)00402-6
05/2001
The Regulation of Apoptosis by Activin and Transforming Growth Factor-ß in Early Neoplastic and Tumorigenic Ovarian Surface Epithelium1
The Journal of Clinical Endocrinology & Metabolism
Kyung-Chul Choi and Sung Keun Kang and Chen-Jei Tai and Nelly Auersperg and Peter C. K. Leung
DOI: 10.1210/jcem.86.5.7478
05/2001
Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells.
Endocrinology
DOI: 10.1210/en.142.4.1554
PubMed: 11250936
04/2001
Functional Mapping of a Placenta-Specific Upstream Promoter for Human Gonadotropin-Releasing Hormone Receptor Gene1
Endocrinology
Kwai Wa Cheng and Billy K. C. Chow and Peter C. K. Leung
DOI: 10.1210/endo.142.4.8104
04/2001
Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology
Endocrine Reviews
DOI: 10.1210/edrv.22.2.0422
04/2001
Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE)
Molecular and Cellular Endocrinology
Kyung-Chul Choi and Sung Keun Kang and Parimal S. Nathwani and Kwai Wa Cheng and Nelly Auersperg and Peter C.K. Leung
DOI: 10.1016/s0303-7207(00)00447-0
03/2001
Coexpression of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis?
Oncogene
DOI: 10.1038/sj.onc.1204253
PubMed: 11313876
03/2001
Stimulation of Mitogen-Activated Protein Kinase by Gonadotropin-Releasing Hormone in Human Granulosa-Luteal Cells
Endocrinology
DOI: 10.1210/endo.142.2.7960
02/2001
Estradiol Regulates Gonadotropin-Releasing Hormone (GnRH) and its Receptor Gene Expression and Antagonizes the Growth Inhibitory Effects of GnRH in Human Ovarian Surface Epithelial and Ovarian Cancer Cells
Endocrinology
DOI: 10.1210/endo.142.2.7982
02/2001
Adenosine Triphosphate-Evoked Cytosolic Calcium Oscillations in Human Granulosa-Luteal Cells: Role of Protein Kinase C1
The Journal of Clinical Endocrinology & Metabolism
Chen-Jei Tai and Sung Keun Kang and Peter C. K. Leung
DOI: 10.1210/jcem.86.2.7231
02/2001
Differential Regulation of Two Forms of Gonadotropin-Releasing Hormone Messenger Ribonucleic Acid in Human Granulosa-Luteal Cells
Endocrinology
DOI: 10.1210/endo.142.1.7895
01/2001
Role of Mitogen-Activated Protein Kinase in Prostaglandin F2aAction in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.86.1.7159
01/2001
Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells
Endocrinology
Tai, C.-J. and Sung Keun Kang and Tzeng, C.-R. and Leung, P.C.K.
DOI: 10.1210/endo.142.4.8081
2001
Interaction of Prostaglandin F_2aand Prostaglandin-E₂on Progesterone Production in Human Granulosa-Luteal Cells
NeuroSignals
DOI: 10.1159/000046905
2001
Functional mapping of a placenta-specific upstream promoter for human gonadotropin-releasing hormone receptor gene
Endocrinology
Kwai Wa Cheng and Chow, B.K.C. and Leung, P.C.K.
DOI: 10.1210/en.142.4.1506
2001
Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates
International Journal of Oncology
H. Lau and Xiao-Ming Zhu and Peter Leung and L. Chan and G. Chen and Peter Chan and K. Yu and Franky Chan
DOI: 10.3892/ijo.19.6.1193
2001
Interaction of prostaglandin F(2alpha) and prostaglandin E(2) on progesterone production in human granulosa-luteal cells.
Biological signals and receptors
PubMed: 11721093
2001
Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells
Endocrinology
Choi, K.-C. and Kang, S.K. and Tai, C.-J. and Auersperg, N. and Leung, P.C.K.
DOI: 10.1210/endo.142.6.8144
2001
Expression and anti-proliferative effect of a second form of gonadotropin-releasing hormone in normal and neoplastic ovarian surface epithelial cells
Journal of Clinical Endocrinology and Metabolism
Choi, K.-C. and Auersperg, N. and Leung, P.C.K.
DOI: 10.1210/jc.86.10.5075
2001
Adenosine triphosphate-evoked cytosolic calcium oscillations in human granulosa-luteal cells: Role of protein kinase C
Journal of Clinical Endocrinology and Metabolism
Tai, C.-J. and Kang, S.K. and Leung, P.C.K.
DOI: 10.1210/jc.86.2.773
2001
Role of mitogen-activated protein kinase in prostaglandin F_2a action in human granulosa-luteal cells
Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jc.86.1.375
2001
The regulation of apoptosis by activin and transforming growth factor-ß in early neoplastic and tumorigenic ovarian surface epithelium
Journal of Clinical Endocrinology and Metabolism
Choi, K.-C. and Kang, S.K. and Tai, C.-J. and Auersperg, N. and Leung, P.C.K.
DOI: 10.1210/jc.86.5.2125
2001
Differentiation and growth potential of human ovarian surface epithelial cells expressing temperature sensitive SV40T antigen
In Vitro Cellular & Developmental Biology - Animal
DOI: 10.1290/1071-2690(2001)0372.0.co;2
2001
Differential role of PR-A and -B isoforms in transcription regulation of human GnRH receptor gene
Molecular Endocrinology
Cheng, K.W. and Cheng, C.-K. and Leung, P.C.K.
DOI: 10.1210/mend.15.12.0739
2001
Transcriptional Down-Regulation of Human Gonadotropin-Releasing Hormone (GnRH) Receptor Gene by GnRH: Role of Protein Kinase C and Activating Protein 1
Endocrinology
DOI: 10.1210/endo.141.10.7730
10/2000
Hormonal Regulation of Estrogen Receptor a and ß Gene Expression in Human Granulosa-Luteal Cellsin Vitro
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.85.10.6886
10/2000
Hepatocyte growth factor promotes in vitro scattering and morphogenesis of human cervical carcinoma cells.
Gynecologic oncology
DOI: 10.1006/gyno.2000.5877
PubMed: 10926796
08/2000
Regulation of Human Gonadotropin-Releasing Hormone Receptor Gene Expression in Placental Cells
Endocrinology
DOI: 10.1210/endo.141.7.7543
07/2000
Regulation of Gonadotropin-Releasing Hormone and Its Receptor Gene Expression by 17ß-Estradiol in Cultured Human Granulosa-Luteal Cells
Endocrinology
DOI: 10.1210/endo.141.5.7447
05/2000
Differential expression of human gonadotropin-releasing hormone receptor gene in pituitary and ovarian cells
Molecular and Cellular Endocrinology
Sung Keun Kang and Kwai Wa Cheng and Elly S.W. Ngan and Billy K.C. Chow and Kyung-Chul Choi and Peter C.K. Leung
DOI: 10.1016/s0303-7207(00)00196-9
04/2000
Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma.
British journal of cancer
DOI: 10.1054/bjoc.1999.1127
PubMed: 10780520
04/2000
Expression and Regulation of P2U-Purinergic Receptor in Human Granulosa-Luteal Cells1
The Journal of Clinical Endocrinology & Metabolism
Chen-Jei Tai and Sung Keun Kang and Kwai Wa Cheng and Kyung-Chul Choi and Parimal S. Nathwani and Peter C. K. Leung
DOI: 10.1210/jcem.85.4.6558
04/2000
Expression and Regulation of P2U-Purinergic Receptor in Human Granulosa-Luteal Cells
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jc.85.4.1591
04/2000
Identification of an Upstream Promoter in the Human Gonadotropin-Releasing Hormone Receptor Gene
Biochemical and Biophysical Research Communications
Elly S.W. Ngan and Peter C.K. Leung and Billy K.C. Chow
DOI: 10.1006/bbrc.2000.2509
04/2000
Role of Gonadotropin-Releasing Hormone as an Autocrine Growth Factor in Human Ovarian Surface Epithelium
Endocrinology
DOI: 10.1210/endo.141.1.7250
01/2000
The expression, regulation and signal transduction pathways of the mammalian gonadotropin-releasing hormone receptor
Canadian Journal of Physiology and Pharmacology
Kwai Wa Cheng and Peter CK Leung
DOI: 10.1139/y00-096
2000
Autocrine Role of Gonadotropin-Releasing Hormone and Its Receptor in Ovarian Cancer Cell Growth
Endocrine
Sung K. Kang and Kwai W. Cheng and Parimal S. Nathwani and Kyung-Chul Choi and Peter C. K. Leung
DOI: 10.1385/endo:13:3:297
2000
Gonadotropin-releasing hormone activates mitogen-activated protein kinase in human ovarian and placental cells
Molecular and Cellular Endocrinology
Sung Keun Kang and Chen-Jei Tai and Kwai Wa Cheng and Peter C.K Leung
DOI: 10.1016/s0303-7207(00)00320-8
2000
Extrapituitary gonadotropin-releasing hormone (GnRH) receptor
Hormone Frontier in Gynecology
2000
Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression
Endocrinology
DOI: 10.1210/endo.140.6.6759
06/1999
Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: Influence of family history of ovarian cancer
International Journal of Cancer
Alice S.T. Wong and Sarah L. Maines-Bandiera and Barry Rosen and Margaret J. Wheelock and Keith R. Johnson and Peter C.K. Leung and Calvin D. Roskelley and Nelly Auersperg
DOI: 10.1002/(sici)1097-0215(19990412)81:23.0.co;2-7
04/1999
Human ovary and placenta express messenger RNA for multiple activin receptors
Life Sciences
Chun Peng and Tsukasa Ohno and Loo Yee Koh and Victor T.S. Chen and Peter C.K. Leung
DOI: 10.1016/s0024-3205(99)00035-1
02/1999
Human Peripheral Blood Mononuclear Cells Express Gonadotropin-Releasing Hormone (GnRH), GnRH Receptor, and Interleukin-2 Receptor ¿-Chain Messenger Ribonucleic Acids That Are Regulated by GnRHin Vitro
The Journal of Clinical Endocrinology & Metabolism
DOI: 10.1210/jcem.84.2.5440
02/1999
Human peripheral blood mononuclear cells express gonadotropin-releasing hormone (GnRH), GnRH receptor, and interleukin-2 receptor ¿-chain messenger ribonucleic acids that are regulated by GnRH in vitro
Journal of Clinical Endocrinology and Metabolism
Chen, H.-F. and Jeung, E.-B. and Stephenson, M. and Leung, P.C.K.
DOI: 10.1210/jc.84.2.743
1999
Cell survival effect of activin against heat shock stress on OVCAR3
Life Sciences
Jun Fukuda and Ikuro Ito and Toshinobu Tanaka and Peter C.K. Leung
DOI: 10.1016/s0024-3205(98)00505-0
11/1998
Metaplastic changes in cultured human ovarian surface epithelium.
In vitro cellular & developmental biology. Animal
DOI: 10.1007/s11626-998-0059-0
PubMed: 9794215
10/1998
Regulation of prostaglandin F2alpha-receptor mRNA in human granulosa-luteal cells by human chorionic gonadotrophin and prostaglandin F2alpha.
Endocrine
DOI: 10.1385/endo:8:3:261
PubMed: 9741831
06/1998
Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway.
Endocrine
DOI: 10.1385/endo:8:3:301
PubMed: 9741835
06/1998
Expression of the messenger RNA for gonadotropin-releasing hormone and its receptor in human cancer cell lines
Life Sciences
Hong Yin and Kwai Wa Cheng and Hsiao-Lin Hwa and Chun Peng and Nelly Auersperg and Peter C.K. Leung
DOI: 10.1016/s0024-3205(98)00173-8
04/1998
Interaction of prostaglandin F2alpha and gonadotropin-releasing hormone on progesterone and estradiol production in human granulosa-luteal cells.
Biology of reproduction
DOI: 10.1095/biolreprod57.6.1346
PubMed: 9408239
12/1997
Efficient introduction of genes into human ovarian surface epithelium
In Vitro Cellular & Developmental Biology - Animal
Earnest H. Leung and Barry R. Davies and Peter C. K. Leung and George T. C. Chen and Calvin D. Roskelley and Nelly Auersperg
DOI: 10.1007/s11626-997-0120-4
09/1997
Mechanisms involved in ATP-evoked Ca2+ oscillations in isolated human granulosa-luteal cells.
Cell calcium
DOI: 10.1016/s0143-4160(97)90030-0
PubMed: 9174649
05/1997
Characterization and regulation of a mRNA encoding the prostaglandin F2alpha receptor in the rat ovary.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(96)03894-4
PubMed: 8912810
10/1996
P2-purinoreceptor evoked changes in intracellular calcium oscillations in single isolated human granulosa-lutein cells.
Endocrinology
P S Lee and P E Squires and A M Buchan and B H Yuen and P C Leung
DOI: 10.1210/endo.137.9.8756543
09/1996
Quantitation of activin receptor type-I mRNA by competitive PCR in human trophoblast cells
Placenta
Victor Chen and Jessica Dy and Chun Peng and Peter C.K. Leung
DOI: 10.1016/s0143-4004(96)90203-9
07/1996
Long-term growth and steroidogenic potential of human granulosa-lutein cells immortalized with SV40 large T antigen
Molecular and Cellular Endocrinology
Byong-Lyul Lie and Earnest Leung and Peter C.K. Leung and Nelly Auersperg
DOI: 10.1016/0303-7207(96)03835-x
07/1996
Molecular characterisation of the gonadotropin-releasing hormone receptor gene
Animal Reproduction Science
Peter C.K. Leung and Nancy C. Fan and Chun Peng
DOI: 10.1016/0378-4320(96)01482-0
04/1996
Gonadotropin-Releasing Hormone Receptor: Gene Structure, Expression and Regulation
Neurosignals
Peter C.K. Leung and Chun Peng
DOI: 10.1159/000109175
1996
Prostaglandins and Their Receptors: Implications for Ovarian Physiology
Neurosignals
Jan I. Olofsson and Peter C.K. Leung
DOI: 10.1159/000109178
1996
Hormone receptors and signaling in reproduction
NeuroSignals
DOI: 10.1159/000109174
1996
Activin and Follistatin as Local Regulators in the Human Ovary
Neurosignals
Chun Peng and Tsukasa Ohno and Shideh Khorasheh and Peter C.K. Leung
DOI: 10.1159/000109177
1996
Purinoreceptor-mediated calcium signalling in isolated human granulosa-lutein cells
Endocrinology
1996
Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization.
Mammalian genome : official journal of the International Mammalian Genome Society
DOI: 10.1007/bf00352431
PubMed: 7613048
04/1995
The baboon expresses the calbindin-D9k gene in intestine but not in uterus and placenta: Implication for conservation of the gene in primates
Molecular Reproduction and Development
Eui-Bae Jeung and Nancy C. Fan and Peter C. K. Leung and John C. Herr and Alex Freemerman and John Krisinger
DOI: 10.1002/mrd.1080400403
04/1995
Homologous and heterologous regulation of gonadotropin-releasing hormone receptor gene expression in preovulatory rat granulosa cells.
Endocrinology
J I Olofsson and C C Conti and P C Leung
DOI: 10.1210/endo.136.3.7867607
03/1995
The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals
Molecular and Cellular Endocrinology
Nancy C Fan and Chun Peng and John Krisinger and Peter C.K Leung
DOI: 10.1016/0303-7207(94)03460-b
02/1995
Porcine Calbindin-D9k Gene: Expression in Endometrium, Myometrium, and Placenta in the Absence of a Functional Estrogen Response Element in Intron A
Biology of Reproduction
DOI: 10.1095/biolreprod52.1.115
01/1995
Expression and regulation of gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acids in human granulosa-luteal cells.
Endocrinology
DOI: 10.1210/endo.135.5.7956897
PubMed: 7956897
11/1994
The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(94)90087-6
PubMed: 7958384
07/1994
Expression of calbindin-D9k in the early pregnant rat uterus: Effects of RU 486 and correlation to estrogen receptor mRNA
Molecular and Cellular Endocrinology
John Krisinger and Takuya Setoyama and Peter C.K. Leung
DOI: 10.1016/0303-7207(94)90092-2
06/1994
Auto/paracrine role of prostaglandins in corpus luteum function
Molecular and Cellular Endocrinology
Jan Olofsson and Peter C.K. Leung
DOI: 10.1016/0303-7207(94)90284-4
04/1994
Gonadotropin-releasing hormone (GnRH) and cyclic amp positively regulate inhibin subunit messenger RNA levels in human placental cells
Life Sciences
Wei Li and Jan I. Olofsson and Eui-Bae Jeung and John Krisinger and Basil Ho Yuen and Peter C.K. Leung
DOI: 10.1016/0024-3205(94)00340-8
01/1994
The Human Calbindin-D9k Gene
Journal of Molecular Biology
Eui-Bae Jeung and Peter C.K. Leung and John Krisinger
DOI: 10.1006/jmbi.1994.1076
01/1994
Tissue-specific regulation of gonadotropin-releasing hormone (GnRH) receptor gene expression during the periovulatory period
Endocrine
1994
Expression of the type II activin receptor gene in the human placenta.
Endocrinology
DOI: 10.1210/en.133.6.3046
PubMed: 8243335
12/1993
Cytosolic free Ca2+ in human syncytiotrophoblast cells increased by gonadotropin-releasing hormone
Endocrinology
W. D. Currie
DOI: 10.1210/en.133.5.2220
11/1993
Calbindin-D9k gene expression during the perinatal period in the rat: correlation to estrogen receptor expression in uterus
Molecular and Cellular Endocrinology
John Krisinger and Jamie L. Dann and Oliver Applegarth and W.David Currie and Eui-Bae Jeung and Michael Staun and Peter C.K. Leung
DOI: 10.1016/0303-7207(93)90211-2
11/1993
Acute stimulation of human chorionic gonadotropin secretion by recombinant human activin-A in first trimester human trophoblast.
Endocrinology
DOI: 10.1210/endo.133.1.8319577
PubMed: 8319577
07/1993
Stimulation of progesterone secretion by recombinant follistatin-288 in human granulosa cells.
Endocrinology
DOI: 10.1210/endo.132.4.8384994
PubMed: 8384994
04/1993
Arachidonic acid and cell signalling in the ovary and placenta.
Prostaglandins, leukotrienes, and essential fatty acids
DOI: 10.1016/0952-3278(93)90013-m
PubMed: 8424126
01/1993
Characterization of Cell Types within a Chorionic Gonadotropin-Secreting, Mechanically Dissociated Human Placental Cell Population in Perifusion
Neurosignals
Gillian L. Steele and David Currie and Basil Ho Yuen and Peter C.K. Leung
DOI: 10.1159/000109487
1993
Expression of the type II activin receptor gene in the human placenta
Endocrinology
1993
Signal Transduction of PGF2a in Rat Corpora Lutea
Molecular Basis of Reproductive Endocrinology
Gillian L. Steele and Peter C. K. Leung
DOI: 10.1007/978-1-4613-9260-6_21
1993
LHRH-and (Hydroxyproline⁹) LHRH-stimulated hCG secretion from perifused first-trimester placental cells
Recent Progress in Hormone Research
Currie, W.D. and Steele, G.L. and Yuen, B.H. and Kordon, C. and Gautron, J.-P. and Leung, P.C.K.
1993
Arachidonic Acid as a Second Messenger for Regulation of Aromatase Activity in Porcine Granulosa Cells
Molecular Basis of Reproductive Endocrinology
F. Ledwitz-Rigby and M. K. Nickerson and S. W. Lin and Peter C. K. Leung
DOI: 10.1007/978-1-4613-9260-6_18
1993
Acute stimulation of human chorionic gonadotropin secretion by recombinant human activin-A in first trimester human trophoblast
Endocrinology
1993
GnRH- and cAMP-Stimulated Human Chorionic Gonadotropin Secretion from Perifused Placental Cells
Molecular Basis of Reproductive Endocrinology
W. David Currie and Gillian L. Steele and Basil Ho-Yuen and Peter C. K. Leung
DOI: 10.1007/978-1-4613-9260-6_25
1993
Cytosolic free Ca²⁺ in human syncytiotrophoblast cells increased by gonadotropin-releasing hormone
Endocrinology
1993
Mechanism of prostaglandin F2 alpha action in the ovary.
Journal of lipid mediators
PubMed: 8358010
1993
LHRH- and (Hydroxyproline9) LHRH-Stimulated hCG Secretion from Perifused First-Trimester Placental Cells
Recent Progress in Hormone Research
W. DAVID CURRIE and GILLIAN L. STEELE and BASIL HO YUEN and CLAUDE KORDON and J.-PIERRE GAUTRON and Peter C.K. Leung
DOI: 10.1016/b978-0-12-571148-7.50026-9
1993
Molecular Basis of Reproductive Endocrinology
DOI: 10.1007/978-1-4613-9260-6
1993
LHRH- and (hydroxyproline9) LHRH-stimulated hCG secretion from perifused first-trimester placental cells.
Recent progress in hormone research
PubMed: 8441858
1993
Divergent differentiation of rat adrenocortical cells is associated with an interruption of angiotensin II-mediated signal transduction
Molecular and Cellular Endocrinology
Calvin D Roskelley and Kenneth G Baimbridge and Peter C.K Leung and Nelly Auersperg
DOI: 10.1016/0303-7207(92)90213-p
11/1992
Cloning of the Porcine Calbindin-D9k Complementary Deoxyribonucleic Acid by Anchored Polymerase Chain Reaction Technique1
Biology of Reproduction
Eui-Bae Jeung and John Krisinger and Jamie L. Dann and Peter C. K. Leung
DOI: 10.1095/biolreprod47.4.503
10/1992
Calbindin-D9k gene expression during pregnancy and lactation in the rat
Molecular and Cellular Endocrinology
J. Krisinger and J.L. Dann and E.B. Jeung and P.C.K. Leung
DOI: 10.1016/0303-7207(92)90016-y
10/1992
Rapid stimulation of human chorionic gonadotropin secretion by interleukin-1 beta from perifused first trimester trophoblast.
The Journal of Clinical Endocrinology & Metabolism
G L Steele and W D Currie and E H Leung and B H Yuen and P C Leung
DOI: 10.1210/jcem.75.3.1517367
09/1992
Intracellular calcium and the signaling mechanism of luteinizing hormone—releasing hormone in rat granulosa cells
American Journal of Obstetrics and Gynecology
Jian Wang and Gillian L. Steele and Kenneth G. Baimbridge and Marie R. Rodway and Peter C.K. Leung
DOI: 10.1016/s0002-9378(11)91450-1
08/1992
Intracellular signaling in the gonads.
Endocrine reviews
DOI: 10.1210/er.13.3.476
PubMed: 1425484
08/1992
Calbindin-D9k mRNA is tightly regulated during the estrous cycle in the rat uterus.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(92)90182-6
PubMed: 1511778
07/1992
Molecular cloning of the full-length cDNA encoding the human calbindin-D9k
FEBS Letters
Eui-Bae Jeung and John Krisinger and Jamie L. Dann and Peter C.K. Leung
DOI: 10.1016/0014-5793(92)80772-9
07/1992
Inhibition of progestin accumulation by activin-A in human granulosa cells.
The Journal of clinical endocrinology and metabolism
DOI: 10.1210/jc.75.1.285
PubMed: 1320053
07/1992
Cytosolic free calcium increased by prostaglandin F2 alpha (PGF2 alpha), gonadotropin-releasing hormone, and angiotensin II in rat granulosa cells and PGF2 alpha in human granulosa cells.
Endocrinology
DOI: 10.1210/endo.130.4.1547713
PubMed: 1547713
04/1992
Prostaglandin F2a and gonadotropin-releasing hormone increase intracellular free calcium in rat granulosa cells
Molecular and Cellular Endocrinology
Marie R. Rodway and Gillian L. Steele and Kenneth G. Baimbridge and Peter C.K. Leung
DOI: 10.1016/0303-7207(92)90080-p
03/1992
Intragonadal signalling mechanisms in the control of steroid hormone production
The Journal of Steroid Biochemistry and Molecular Biology
Gillian L. Steele and Peter C.K. Leung
DOI: 10.1016/0960-0760(92)90376-t
03/1992
Inhibition of progestin accumulation by activin-A in human granulosa cells
Journal of Clinical Endocrinology and Metabolism
Li, W. and Yuen, B.H. and Leung, P.C.K.
DOI: 10.1210/jcem.75.1.1320053
1992
Cytosolic free calcium increased by prostaglandin F_2a (PGF_2a), gonadotropin-releasing hormone, and angiotensin II in rat granulosa cells and PGF_2a in human granulosa cells
Endocrinology
1992
Mechanism of prostaglandin F(2a) action in the ovary
Journal of Lipid Mediators
1992
Rapid stimulation of human chorionic gonadotropin secretion by interleukin-1ß from perifused first trimester trophoblast
Journal of Clinical Endocrinology and Metabolism
1992
Intracellular signaling in the gonads
Endocrine Reviews
Leung, P.C.K. and Steele, G.L.
DOI: 10.1210/edrv-13-3-476
1992
Luteinizing Hormone-Releasing Hormone (LHRH)- and (Hydroxyproline⁹)LHRH-stimulated human chorionic gonadotropin secretion from perifused first trimester placental cells
Endocrinology
1992
Suppression of Luteinizing Hormone Secretion by Atrial and Brain Natriuretic Peptides in Ovariectomized Rats
Endocrinology
DOI: 10.1210/endo-129-2-801
08/1991
Effect of prostaglandin F2 alpha on cytosolic free calcium ion concentrations in rat luteal cells.
Endocrinology
DOI: 10.1210/endo-129-2-889
PubMed: 1855479
08/1991
Inositol Lipid Metabolism and Calcium Signaling in Rat Ovarian Cells
Signaling Mechanisms and Gene Expression in the Ovary
Marie R. Rodway and Peter C. K. Leung
DOI: 10.1007/978-1-4612-3200-1_3
1991
Effect of prostaglandin F_2a on cytosolic free calcium ion concentrations in rat luteal cells
Endocrinology
1991
Androgens Positively Regulate Follicle-Stimulating Hormone ß-Subunit mRNA Levels in Rat Pituitary Cells
Molecular Endocrinology
Soheyla D. Gharib and Peter C. K. Leung and Rona S. Carroll and William W. Chin
DOI: 10.1210/mend-4-11-1620
11/1990
Inhibition of aromatase activity by 8-bromo-cyclic adenosine monophosphate in cultured first-trimester human trophoblast
American Journal of Obstetrics and Gynecology
Marie R Rodway and Basil Ho Yuen and Peter C.K Leung
DOI: 10.1016/0002-9378(90)90623-f
11/1990
The physiological basis of superovulation
Seminars in Reproductive Physiology
1990
Mechanism of action of luteinizing hormone-releasing hormone in rat ovarian cells
Canadian Journal of Physiology and Pharmacology
Peter C. K. Leung and Jian Wang and Kenneth G. Baimbridge
DOI: 10.1139/y89-152
08/1989
Ovarian follicular development and regression
Canadian Journal of Physiology and Pharmacology
Peter C. K. Leung
DOI: 10.1139/y89-149
08/1989
Synergistic stimulation of prostaglandin E2 production by calcium ionophore and protein kinase C activator in rat granulosa cells.
Biology of reproduction
DOI: 10.1095/biolreprod40.5.1000
PubMed: 2504300
05/1989
Arachidonic Acid as a Stimulatory Mediator of Luteinizing Hormone-Releasing Hormone Action in the Rat Ovary
Endocrinology
DOI: 10.1210/endo-124-4-1973
04/1989
Differential role of protein kinase C in the action of luteinizing hormone-releasing hormone on hormone production in rat ovarian cells
American Journal of Obstetrics and Gynecology
J. Wang and V. Lee and P.C.K. Leung
DOI: 10.1016/0002-9378(89)90321-9
04/1989
The Role of Inositol Lipid Metabolism in the Ovary
Biology of Reproduction
Peter C. K Leung and Jian Wang
DOI: 10.1095/biolreprod40.4.703
04/1989
Changes in Cytosolic Free Calcium Ion Concentrations in Individual Rat Granulosa Cells: Effect of Luteinizing Hormone-Releasing Hormone*
Endocrinology
JIAN WANG and KENNETH G. BAIMBRIDGE and PETER C. K. LEUNG
DOI: 10.1210/endo-124-4-1912
04/1989
Perturbation of intracellular calcium ion concentration in single Rat Granulosa Cells by Angiotensin II
Endocrinology
DOI: 10.1210/endo-124-2-1094
02/1989
Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid.
FEBS letters
DOI: 10.1016/0014-5793(89)81182-2
PubMed: 2494061
02/1989
Role of Calcium in the Action of LHRH on Ovarian Progesterone Production
Growth Factors and the Ovary
Peter C. K. Leung and Jian Wang
DOI: 10.1007/978-1-4684-5688-2_33
1989
Synergistic stimulation of prostaglandin E₂ production by calcium ionophore and protein kinase C activator in rat granulosa cells
Biology of Reproduction
1989
A randomized study of high-dose versus low-dose cis-platinum combined with cyclophosphamide in the treatment of advanced ovarian cancer
Chemotherapy
Ngan, H.Y.S. and Choo, Y.C. and Cheung, M. and Wong, L.C. and Ma, H.K. and Collins, R. and Fung, C. and Ng, C.S. and Wong, V. and Ho, H.C. and Leung, P. and Wong, R. and Chan, E. and Simon, M.T.P. and Ho, L.C. and Chan, Y.F.
DOI: 10.1159/000238673
1989
Inositol lipids and LHRH action in the rat ovary.
Journal of reproduction and fertility. Supplement
PubMed: 2509693
1989
Effects of cyclic adenosine monophosphate on Human chorionic gonadotropin and Ostradiol output by cultured Human placental cells,Einfluss von zyklischem Adenosinmonophosphat auf die Freisetzung von humanem Choriongonadotropin und Östradiol aus kultivierten humanen Plazentazellen
Gynakologisch-geburtshilfliche Rundschau
Benoit, J. and Rodway, M. and Yuen, B.H. and Leung, P.C.K.
DOI: 10.1159/000270938
1989
Electrical Stimulation of Ascending Noradrenergic Tracts in the Midbrain: Suppression of Steroid-Induced Luteinizing Hormone Release
Endocrinology
DOI: 10.1210/endo-122-3-899
03/1988
Role of Arachidonic Acid in Luteinizing Hormone-Releasing Hormone Action: Stimulation of Progesterone Production in Rat Granulosa Cells*
Endocrinology
JIAN WANG and PETER C. K. LEUNG
DOI: 10.1210/endo-122-3-906
03/1988
Inhibition of follicle-stimulating hormone- and adenosine-3',5'-cyclic monophosphate-induced progesterone production by calcium and protein kinase C in the rat ovary.
American journal of obstetrics and gynecology
DOI: 10.1016/0002-9378(88)90153-6
PubMed: 2829629
02/1988
Differential effects of 8-bromo-cyclic AMP on human chorionic gonadotropin (hCG), progesterone and estrogen production by term placental cells
Life Sciences
Marie Rodway and Fuzhen Zhou and Joanne Benoit and Basil Ho Yuen and Peter C.K. Leung
DOI: 10.1016/0024-3205(88)90256-1
01/1988
Effects of cyclic adenosine monophosphate on human chorionic gonadotropin and estradiol output by cultured human placental cells
American Journal of Obstetrics and Gynecology
Joanne Benoit and Marie Rodway and Basil Ho Yuen and Peter C.K. Leung
DOI: 10.1016/0002-9378(88)90148-2
1988
Role of testosterone in the regulation of rat ovarian estradiol-17b secretion
Life Science Advances
1988
Inhibition of follicle-stimulating hormone- and adenosine-3’, 5’-cyclic monophosphate-induced progesterone production by calcium and protein kinase C in the rat ovary
Obstetrical and Gynecological Survey
Leung, P.C.K. and Minegishi, T. and Wang, J.
DOI: 10.1097/00006254-198807000-00015
1988
Role of protein kinase C in luteinizing hormone-releasing hormone (LHRH)-stimulated progesterone production in rat granulosa cells
Biochemical and Biophysical Research Communications
Jian Wang and Peter C.K. Leung
DOI: 10.1016/0006-291x(87)90737-6
08/1987
Luteinizing hormone-releasing hormone (LHRH)-induced arachidonic acid release in rat granulosa cells Role of calcium and protein kinase C
FEBS Letters
T. Minegishi and J. Wang and P.C.K. Leung
DOI: 10.1016/0014-5793(87)80029-7
04/1987
Effects of adenosine 3',5'-cyclic monophosphate, forskolin, and cholera toxin on hormone production in human term placental cells.
American journal of obstetrics and gynecology
DOI: 10.1016/0002-9378(87)90296-1
PubMed: 3030108
02/1987
Dual Action of Norepinephrine in the Control of Gonadotropin Release
Endocrinology and Physiology of Reproduction
Hugo Bergen and Peter C. K. Leung
DOI: 10.1007/978-1-4899-1971-7_9
1987
Electrical Stimulation of Ventral versus Dorsal Mesencephalic Tegmental Areas in the Conscious Rat: Effects on Luteinizing Hormone Release
Neuroendocrinology
Hugo Bergen and Peter C.K. Leung
DOI: 10.1159/000124807
1987
Induction of Polyphosphoinositide Breakdown in Rat Corpus Luteum by Prostaglandin F2a
Endocrinology
DOI: 10.1210/endo-119-1-12
07/1986
Norepinephrine inhibition of pulsatile LH release: receptor specificity.
The American journal of physiology
PubMed: 3953791
02/1986
Alleviation of Estrogen-Induced Hyperprolactinemia through Intracerebral Transplantation of Hypothalamic Tissue Containing Dopaminergic Neurons
Neuroendocrinology
Gary W. Arendash and Peter C.K. Leung
DOI: 10.1159/000124551
1986
Relationship of gonadotropin-releasing hormone, danazol, and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit
American Journal of Obstetrics and Gynecology
Pride, S.M. and Ho Yuen, B. and Moon, Y.S. and Leung, P.C.S.
DOI: 10.1016/0002-9378(86)90778-7
1986
Suppression of Progesterone-Induced Gonadotropin Surge by Adrenergic Agonists in Estrogen-Primed Ovariectomized Rats
Neuroendocrinology
Hugo Bergen and Peter C.K. Leung
DOI: 10.1159/000124555
1986
Norepinephrine inhibition of pulsatile LH release: Receptor specificity
American Journal of Physiology - Endocrinology and Metabolism
Bergen, H. and Leung, P.C.K.
DOI: 10.1152/ajpendo.1986.250.2.e205
1986
Luteinizing Hormone-Releasing Hormone Stimulates Arachidonic Acid Release in Rat Granulosa Cells
Endocrinology
DOI: 10.1210/endo-117-5-2001
11/1985
Effects of cannabinoids on progesterone release in cultures of rat luteal cells
Life Sciences
Peter C.K. Leung and Michael Flesher and Young S. Moon and Takashi Minegishi
DOI: 10.1016/0024-3205(85)90296-6
11/1985
Luteinizing hormone-releasing hormone enhances polyphosphoinositide breakdown in rat granulosa cells
Biochemical and Biophysical Research Communications
Felix Ma and Peter C.K. Leung
DOI: 10.1016/0006-291x(85)91742-5
08/1985
Effects of prostaglandins and luteinizing hormone-releasing hormone on phosphatidic acid – phosphatidylinositol labeling in rat granulosa cells
Canadian Journal of Physiology and Pharmacology
Takashi Minegishi and Peter C. K. Leung
DOI: 10.1139/y85-058
04/1985
Mechanisms of gonadotropin-releasing hormone and prostaglandin action on luteal cells
Canadian Journal of Physiology and Pharmacology
Peter C. K. Leung
DOI: 10.1139/y85-046
03/1985
Vasopressin rapidly stimulates phosphatidic acid-phosphatidylinositol turnover in rat anterior pituitary cells.
FEBS letters
DOI: 10.1016/0014-5793(85)81183-2
PubMed: 3972124
03/1985
LHRH rapidly stimulates phosphatidylinositol metabolism in enriched gonadotrophs
Molecular and Cellular Endocrinology
Vincent Raymond and Peter C.K. Leung and Raymonde Veilleux and Gérard Lefèvre and Fernand Labrie
DOI: 10.1016/0303-7207(84)90031-5
07/1984
Stimulation by prostaglandin F2 alpha of phosphatidic acid-phosphatidylinositol turnover in rat luteal cells.
Biochemical and biophysical research communications
DOI: 10.1016/0006-291x(83)90377-7
PubMed: 6357198
10/1983
Androgenic alteration in pathways of C19-steroid metabolism by cultured rat granulosa cells.
Biochemical and biophysical research communications
DOI: 10.1016/0006-291x(83)91090-2
PubMed: 6870903
06/1983
Stimulation of phosphatidic acid and phosphtidylinositol labeling in luteal cells by luteinizing hormone releasing hormone
Endocrinology
DOI: 10.1210/endo-112-3-1138
03/1983
Effect of prolactin in an experimental model of the ovarian hyperstimulation syndrome
American Journal of Obstetrics and Gynecology
Leung, P. and Yuen, B.H. and Moon, Y.S.
DOI: 10.1016/0002-9378(83)90690-7
1983
Role of norepinephrine in seizurelike activity of hippocampal pyramid cells maintained in vitro: Alteration by 6-hydroxydopamine lesions of norepinephrine-containing systems
Canadian Journal of Physiology and Pharmacology
Mody, I. and Leung, P. and Miller, J.J.
DOI: 10.1139/y83-129
1983
Mechanism of action of TRH: involvement of the phosphatidylinositol (PI) response in the action of TRH in rat anterior pituitary cells.
Life sciences
DOI: 10.1016/0024-3205(82)90072-8
PubMed: 6819422
12/1982
Differential effects of central adrenoceptor agonists on luteinizing hormone release.
Neuroendocrinology
DOI: 10.1159/000123301
PubMed: 6280093
03/1982
Electrophysiologic correlates of steroid modulation of luteinizing hormone release.
The American journal of physiology
PubMed: 7065175
03/1982
beta-Adrenergic suppression of progesterone-induced luteinizing hormone surge in ovariectomized, estrogen-primed rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
PubMed: 6278508
02/1982
Electrophysiologic correlates of steroid modulation of luteinizing hormone release
American Journal of Physiology - Endocrinology and Metabolism
Leung, P.C.K. and Whitmoyer, D.I. and Sawyer, C.H.
DOI: 10.1152/ajpendo.1982.242.3.e164
1982
ß-Adrenergic Suppression of Progesterone-Induced Luteinizing Hormone Surge in Ovariectomized, Estrogen-Primed Rats (41326)
Proceedings of the Society for Experimental Biology and Medicine
Leung, P.C.K. and Whitmoyer, D.I. and Garland, K.E. and Sawyer, C.H.
DOI: 10.3181/00379727-169-41326
1982
Metabolism of testosterone by human granulosa cells in culture: Influence of follicle-stimulating hormone and luteinizing hormone
American Journal of Obstetrics and Gynecology
Moon, Y.S. and Duleba, A. and Leung, P.C.S. and Gomel, V.
DOI: 10.1016/S0002-9378(16)32442-5
1982
Effect of an aromatase inhibitor (4-acetoxy-4-androstene-3,17-dione) on the stimulatory action of luteinizing hormone on estradiol-17 beta synthesis by rat preovulatory follicles in vitro.
Biology of reproduction
DOI: 10.1095/biolreprod25.2.290
PubMed: 7306626
09/1981
Electrical Stimulation of Mesencephalic Noradrenergic Pathway: Effects on Luteinizing Hormone Levels in Blood of Ovariectomized and Ovariectomized, Steroid-Primed Rats
Endocrinology
DOI: 10.1210/endo-109-3-720
09/1981
Effects of intraventricular infusion of a- and ß-adrenoceptor agonists on blood levels of luteinizing hormone (LH) in ovariectomized (OVX) and OVX steroid-primed rats
Anatomical Record
Leung, P.C.K. and Arendash, G.W. and Whitmoyer, D.I.
1981
Prostaglandin F in human endometriotic tissue
American Journal of Obstetrics and Gynecology
Moon, Y.S. and Leung, P.C.S. and Ho Yuen, B. and Gomel, V.
DOI: 10.1016/S0002-9378(16)32641-2
1981
Norepinephrine-induced changes in multiunit electrical activity (MUA) of rostral diencephalon and mediobasal hypothalamus: Neural substrate for steroidal modulation of LH release?
Biology of Reproduction
Leung, P.C.K. and Whitmoyer, D.I. and Sawyer, C.H.
1981
Effect of bromocriptine and prolactin on the ovarian response to exogenous gonadotropins
Fertility and Sterility
Ho Yuen, B. and Leung, P. and Moon, Y.S.
1981
Effects of intraventricular norepinephrine on preoptic-anterior hypothalamic electrical activity in the freely-moving rat: modulation by ovarian steroid hormones
Brain Research
Peter C.K. Leung and David I. Whitmoyer and Gary W. Arendash and Charles H. Sawyer
DOI: 10.1016/0006-8993(81)91089-1
1981
Further evidence in support of a short-loop feedback action of estrogen on ovarian androgen production
Life Sciences
Peter C.K. Leung and David T. Armstrong
DOI: 10.1016/0024-3205(80)90190-3
08/1980
Interactions of steroids and gonadotropins in the control of steroidogenesis in the ovarian follicle.
Annual review of physiology
DOI: 10.1146/annurev.ph.42.030180.000443
PubMed: 6773470
1980
Effect of mesencephalic electrical stimulation on blood luteinizing hormone (LH) levels in ovariectomized (OVX) and OVX, steroid-primed rats
Biology of Reproduction
Leung, P.C.K. and Arendash, G.W. and Gorski, R.A. and Sawyer, C.H.
1980
A Mechanism for the Intraovarian Inhibitory Action of Estrogen on Androgen Production1
Biology of Reproduction
Peter C. K. Leung and David T. Armstrong
DOI: 10.1095/biolreprod21.4.1035
11/1979
Estrogen Treatment of Immature Rats Inhibits Ovarian Androgen Production in Vitro
Endocrinology
DOI: 10.1210/endo-104-5-1411
05/1979
Inhibition by estradiol-17 beta of porcine thecal androgen production in vitro.
Molecular and cellular endocrinology
DOI: 10.1016/0303-7207(79)90101-1
PubMed: 223899
05/1979
Interactions of Estrogen and Androgen with Gonadotropins on Ovarian Progesterone Production1
Biology of Reproduction
Peter C. K. Leung and Keith M. Henderson and David T. Armstrong
DOI: 10.1095/biolreprod20.4.713
05/1979
Stimulatory action of androgen administration in vivo on ovarian responsiveness to gonadotropins.
Endocrinology
DOI: 10.1210/endo-104-4-1119
PubMed: 220024
04/1979
Stimulatory action of follicle-stimulating hormone and androgens on the responsiveness of rat granulosa cells to gonadotropins in vitro.
Endocrinology
DOI: 10.1210/endo-104-4-1124
PubMed: 220025
04/1979
Testosterone restores ovarian aromatase activity in rats treated with a 17,20-lyase inhibitor
Molecular and Cellular Endocrinology
Yair Katz and Peter C.K. Leung and David T. Armstrong
DOI: 10.1016/0303-7207(79)90056-x
04/1979
Estrogen inhibits porcine thecal androgen production in vitro.
Advances in experimental medicine and biology
Leung, P.C. and Tsang, B.K. and Armstrong, D.T.
DOI: 10.1007/978-1-4684-3474-3_29
1979
Changes with age in aromatization of testosterone in immature female rats.
Biology of reproduction
DOI: 10.1095/biolreprod19.5.1036
PubMed: 743539
12/1978
An intraovarian inhibitory action of estrogen on androgen production in vivo.
Biology of reproduction
DOI: 10.1095/biolreprod19.3.641
PubMed: 719107
10/1978
Uterotrophic effects of testosterone and 5alpha-dihydrotestosterone in intact and ovariectomized immature female rats.
Biology of reproduction
DOI: 10.1095/biolreprod15.1.107
PubMed: 953105
08/1976
The thyroidal response to chronic goitrogenic stimulation and the persistence of effects of early goitrogenic stimulation
Canadian Journal of Physiology and Pharmacology
Peter Leung and B. E. March
DOI: 10.1139/y76-080
08/1976
Effects of alterations in maternal thyroid metabolism on embryonic thyroid development in the chick
Canadian Journal of Physiology and Pharmacology
B. E. March and Peter Leung
DOI: 10.1139/y76-038
06/1976
Potential Role of Gonadotropin-Releasing Hormone and Estrogen in Ovarian Cancer
Hormonal Carcinogenesis IV
Peter C. K. Leung and Kyung-Chul Choi and Nelly Auersperg
DOI: 10.1007/0-387-23761-5_21
Research: Normal and neoplastic ovarian surface epithelium -endocrine and hereditary influences
The epithelial ovarian carcinomas, which comprise over 85% of human ovarian cancers, arise in the ovarian surface epithelium (OSE). The etiology and early events in the progression of these carcinomas are among the least understood of all major human malignancies because there are no appropriate animal models, and because methods to culture OSE have become available only recently. The purpose of this project is to define the molecular mechanisms which underlie the control of normal and neoplastic OSE cell growth, differentiation and expression of indicators of neoplastic progression, by GnRH and other key reproductive hormones. Also, the hormonal response of OSE isolated from overtly normal ovaries of women with and without family histories of ovarian cancer will be examined, in order to define the specific abnormalities in the OSE that lead to a high risk of developing ovarian cancer. The results of this research will be relevant to the development of more efficient chemotherapeutic methods for ovarian cancer treatment.

Function of GnRH in endometrium and placenta
The establishment of a successful pregnancy is dependent on the coordinated development of the implanting embryo and the lining of the uterus (endometrium). To date, the regulatory factors involved in the development of a uterine environment that promotes embryonic implantation and/or the formation of functional placenta remain poorly characterized. In this project, the regulation of GnRH in endometrial and trophoblast cells undergoing differentiation in culture will be examined. A better understanding of the role of GnRH and related hormones in implantation and placentation is likely to reduce the number of couples assigned the frustrating and costly diagnosis of unexplained infertility.

Endocrine control of reproduction
The aim of this project is to better understand the hormonal control of reproductive function by GnRH. Experiments are designed to test the hypothesis that, in addition to its well-known role in the regulation of pituitary hormone secretion, GnRH is also an autocrine regulator of ovarian hormone production. Further experiments are proposed to examine the regulation of the human GnRH receptor, at the level of gene transcription. It is expected that this research will lead to a better understanding on the cellular and molecular basis underlying the use of GnRH analogs in many different areas of reproductive medicine, such as fertility and sterility, control of ovulation and assisted reproductive technology.

Grants

CIHR Operating Grant - Project
"Regulation of human ovarian granulosa cell function by GDF9 and BMP15"

Honours & Awards

Distinguished Scholar of the Michael Smith Foundation for Health Research - 2001-present
UBC Killam Research Award - 2009
Honorary Professor of the Institute of Zoology, Chinese Academy of Sciences, Beijing - 2002-present

Research Group Members

Arezoo Alemzadeh Mehrizi, Doctoral student
Christian Klausen, Research Associate
Yuxi LI, Visiting International Research Student (VIRS)
Maggie Liu, Visiting Faculty/Researcher
Jiamin Xie, Ph.D student
Jenny Zhang, Visiting Faculty
Hua (Ellen) Zhu
Ellen Zhu, Graduate Student

Peter C.K. Leung

Stories See all

Congratulations to the 2018 UBC Faculty of Medicine Award Recipients!

Congratulations CIHR Spring 2022 Project Grant recipients

Congratulations to the recipients of the 2018 Outstanding Achievement Awards & BCCHR Studentships and Fellowships

Pediatric Sepsis Data Challenge invites researchers to help develop a model to save lives

Congratulations CIHR Spring 2024 Project Grant recipients

Collaboration was key to discovery about newborn immunity

Donate to Research

Peter C.K. Leung

Stories See all

Congratulations to the 2018 UBC Faculty of Medicine Award Recipients!

Congratulations CIHR Spring 2022 Project Grant recipients

Congratulations to the recipients of the 2018 Outstanding Achievement Awards & BCCHR Studentships and Fellowships

Pediatric Sepsis Data Challenge invites researchers to help develop a model to save lives

Congratulations CIHR Spring 2024 Project Grant recipients

Collaboration was key to discovery about newborn immunity

Donate to Research

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