Graft versus host disease (GvHD) is a life-threatening complication that occurs in a majority of patients undergoing a bone marrow transplants from an alternative donor. GvHD occurs when donor T cells recognize host tissues as foreign. My research is understanding how a special subset of T cells, named T regulatory cells (Tregs), can control this process. A long term goal is to generate Tregs in the laboratory for use as a cellular therapy to prevent GvHD.


Current Project
Developing methods to use Tregs as a cellular therapy

Current Project
Developing biomarkers to predict which patients will develop GvHD

Current Projects
Studying tissue derived Tregs from patients with GvHD


Canadian Cancer Society Research Institute Innovative Grant: Generation of antigen specific T regulatory cells to treat GVHD post allogeneicstem cell transplant. Principal Applicant (2013-2015)

Canadian Institutes of Health Research Operating Grant: The role of FOXP3 and IL-1-family cytokines in regulating CD4+ T cell subsets in healthy humans, and in patients with chronic skin inflammation. Co-applicant (2013-2016)

Leukemia & Lymphoma Society of Canada: The effect of ATG on immune reconstitution post HSCT. Principal Applicant (2013-2015)

Canadian Institutes of Health Research Operating Grant: Molecular and Cellular Biology of Th17 cells in health and disease. Co-applicant (2009 - 2013)

Honours & Awards

”In it for life” Mentored Clinician Scientist Award, 2005-2007

VCHRI Global Collaboration Research Award, 2007

Academic Enhancement Fund Award, 2008 – 2010

Research Group Members

Joanna Faulks