Raewyn Broady

Overview: Graft versus host disease (GvHD) is a life-threatening complication that occurs in a majority of patients undergoing a bone marrow transplants from an alternative donor. GvHD occurs when donor T cells recognize host tissues as foreign. My research is understanding how a special subset of T cells, named T regulatory cells (Tregs), can control this process. A long term goal is to generate Tregs in the laboratory for use as a cellular therapy to prevent GvHD.
Research: Current Project
Developing methods to use Tregs as a cellular therapy
Current Project
Developing biomarkers to predict which patients will develop GvHD
Current Projects
Studying tissue derived Tregs from patients with GvHD

Grants

Canadian Cancer Society Research Institute Innovative Grant: Generation of antigen specific T regulatory cells to treat GVHD post allogeneicstem cell transplant. Principal Applicant (2013-2015)
Canadian Institutes of Health Research Operating Grant: The role of FOXP3 and IL-1-family cytokines in regulating CD4+ T cell subsets in healthy humans, and in patients with chronic skin inflammation. Co-applicant (2013-2016)
Leukemia & Lymphoma Society of Canada: The effect of ATG on immune reconstitution post HSCT. Principal Applicant (2013-2015)
Canadian Institutes of Health Research Operating Grant: Molecular and Cellular Biology of Th17 cells in health and disease. Co-applicant (2009 - 2013)

Honours & Awards

”In it for life” Mentored Clinician Scientist Award, 2005-2007
VCHRI Global Collaboration Research Award, 2007
Academic Enhancement Fund Award, 2008 – 2010

Research Group Members

Joanna Faulks

Researcher News See all

BC scientists engineer immune cells to protect organs from transplant rejection

Scientists at BC Children’s Hospital and the University of British Columbia have developed a gene therapy that programs a type of immune cell called T regulatory cells to protect transplanted tissues from rejection by the patient’s immune system.

Continue reading BC scientists engineer immune cells to protect organs from transplant rejection

Kids with harder to manage diabetes improve the most from insulin pumps

Kids with the highest blood-sugar levels experienced the most improvement after starting insulin pump treatment, according to new research. The study suggests insulin pump therapy should be considered for children with higher blood sugar levels to help avert some of the lifelong complications of diabetes.

Continue reading Kids with harder to manage diabetes improve the most from insulin pumps

New “Allergy Check” tool helps to assess the likelihood of having a food allergy

Allergy Check, a new assessment tool that guides users through the likelihood of having a food allergy with just a few clicks, has launched as an app on allergycheck.ca.

Continue reading New “Allergy Check” tool helps to assess the likelihood of having a food allergy

Oral immunotherapy safe for preschool-aged children with peanut allergies

New data published today in the Journal of Allergy and Clinical Immunology: In Practice suggests that oral immunotherapy is safe for preschool-aged children with peanut allergies.

Continue reading Oral immunotherapy safe for preschool-aged children with peanut allergies

New study is the first to identify an expanded section of DNA as the cause of a rare genetic metabolic disorder

A new study from BC Children’s, UBC and an international team of researchers published in the New England Journal of Medicine is the first to identify a rarely-seen type of DNA mutation as the cause of an inherited metabolic disorder.

Continue reading New study is the first to identify an expanded section of DNA as the cause of a rare genetic metabolic disorder

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