Overview

Graft versus host disease (GvHD) is a life-threatening complication that occurs in a majority of patients undergoing a bone marrow transplants from an alternative donor. GvHD occurs when donor T cells recognize host tissues as foreign. My research is understanding how a special subset of T cells, named T regulatory cells (Tregs), can control this process. A long term goal is to generate Tregs in the laboratory for use as a cellular therapy to prevent GvHD.

Research

Current Project
Developing methods to use Tregs as a cellular therapy

Current Project
Developing biomarkers to predict which patients will develop GvHD

Current Projects
Studying tissue derived Tregs from patients with GvHD

Grants

Canadian Cancer Society Research Institute Innovative Grant: Generation of antigen specific T regulatory cells to treat GVHD post allogeneicstem cell transplant. Principal Applicant (2013-2015)

Canadian Institutes of Health Research Operating Grant: The role of FOXP3 and IL-1-family cytokines in regulating CD4+ T cell subsets in healthy humans, and in patients with chronic skin inflammation. Co-applicant (2013-2016)

Leukemia & Lymphoma Society of Canada: The effect of ATG on immune reconstitution post HSCT. Principal Applicant (2013-2015)

Canadian Institutes of Health Research Operating Grant: Molecular and Cellular Biology of Th17 cells in health and disease. Co-applicant (2009 - 2013)

Honours & Awards

”In it for life” Mentored Clinician Scientist Award, 2005-2007

VCHRI Global Collaboration Research Award, 2007

Academic Enhancement Fund Award, 2008 – 2010

Research Group Members

Joanna Faulks