Overview

My focus is in the treatment and long term outcomes of children treated for cancer. My specific focus is in quantifying what complications are seen in survivors of childhood cancer. Specifically, I am interested in trying to identify genetic markers that may identify those who are at risk of a specific complication. We are currently in the process of identifying genes that may explain why 20-50% of children receiving cisplatin have irreversible hearing loss. We have established a database of all adverse events in children treated through the oncology department at BC Children's Hospital. I am also interested in using linked databases to look at hospital utilization in long term survivors. Finally, I am interested in developing clinical trials in pediatric oncology both locally, as well as through the Children's Oncology Group (COG).

Publications

High incidence of acute kidney injury during chemotherapy for childhood acute myeloid leukemia
Pediatric Blood & Cancer
Liezl Du Plessis, Shahrad Rod Rassekh, Cherry Mammen
DOI: 10.1002/pbc.26915
04/2018

Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
Molecular Case Studies
Rebecca Ronsley, S. Rod Rassekh, Yaoqing Shen, Anna F. Lee, Colleen Jantzen, Jessica Halparin, Catherine Albert, Douglas S. Hawkins, Shazhan Amed, Ralph Rothstein, Andrew J. Mungall, David Dix, Geoffrey Blair, Helen Nadel, Steven J.M. Jones, Janessa Laskin, Marco A. Marra, Rebecca J. Deyell
DOI: 10.1101/mcs.a002568
04/2018

Management of germline findings revealed throughout the course of tumor-normal whole genome sequencing in oncology.
Journal of Clinical Oncology
Lim, Howard John and Schrader, Kasmintan A. and Young, Sean and Nelson, Jessica and Fok, Alexandra and Pleasance, Erin and Jones, Martin and Shen, Yaoqing and Armstrong, Linlea and Virani, Alice and Rassekh, Shahrad Rod and Deyell, Rebecca and Yip, Stephen and Roscoe, Robyn and Karsan, Aly and Marra, Marco and Laskin, Janessa J.
DOI: 10.1200/JCO.2017.35.15_suppl.e13113
2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer
British Journal of Clinical Pharmacology
Aminkeng, Folefac and Ross, Colin J. D. and Rassekh, Shahrad R. and Rieder, Michael J. and Bhavsar, Amit P. and Sanatani, Shubhayan and Bernstein, Daniel and Hayden, Michael R. and Amstutz, Ursula and Carleton, Bruce C.
DOI: 10.1111/bcp.13218
2017

Targeted error-suppressed quantification of circulating tumor DNA using semi-degenerate barcoded adapters and biotinylated baits
Scientific Reports
Alcaide, Miguel and Yu, Stephen and Davidson, Jordan and Albuquerque, Marco and Bushell, Kevin and Fornika, Daniel and Arthur, Sarah and Grande, Bruno M. and McNamara, Suzan and du Tertre, Mathilde Couetoux and Batist, Gerald and Huntsman, David G. and Cavallone, Luca and Aguilar, Adriana and Basik, Mark and Johnson, Nathalie A. and Deyell, Rebecca J. and Rassekh, S. Rod and Morin, Ryan D.
DOI: 10.1038/s41598-017-10269-2
2017

The effectiveness of interventions to treat hypothalamic obesity in survivors of childhood brain tumours: a systematic review
Obesity Reviews
Wang, K-W. and Chau, R. and Fleming, A. and Banfield, L. and Singh, S. K. and Johnston, D. L. and Zelcer, S. M. and Rassekh, S. R. and Burrow, S. and Valencia, M. and de Souza, R. J. and Thabane, L. and Samaan, M. C.
DOI: 10.1111/obr.12534
2017

Long-term Outcomes and Complications in Pediatric Ewing Sarcoma
American Journal of Clinical Oncology-Cancer Clinical Trials
Hamilton, Sarah N. and Carlson, Ryan and Hasan, Haroon and Rassekh, Shahrad R. and Goddard, Karen
DOI: 10.1097/COC.0000000000000176
2017

Acute Kidney Injury During Chemotherapy for Acute Myeloid Leukemia
Pediatric Blood & Cancer
Du Plessis, Liezl and Mammen, Cherry and Potts, James and Rassekh, Shahrad
2017

Comparison of hypersensitivity rates to intravenous and intramuscular PEG-asparaginase in children with acute lymphoblastic leukemia: A meta-analysis and systematic review
Pediatric Blood & Cancer
Hasan, Haroon and Shaikh, Omar Mohammad and Rassekh, Shahrad Rod and Howard, A. Fuchsia and Goddard, Karen
DOI: 10.1002/pbc.26200
2017

Comparison of Hypersensitivity Rates to Intravenous and Intramuscular PEG-Asparaginase in Children with Acute Lymphoblastic Leukemia: A Meta-Analysis and Systematic Review
Pediatric Blood & Cancer
Hasan, H. and Shaikh, O. M. and Rassekh, S. R. and Howard, A. F. and Goddard, K.
2016

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children (vol 16, pg 1065, 2015)
Pharmacogenomics
Visser, Henk and Rassekh, S. Rod and Sandor, George S.
2016

Harnessing the power of big data to advance pediatric cancer care
Cancer Research
Morozova, Olena and Newton, Yulia and Cline, Melissa and Yip, Stephen and Rao, Arjun and Stuart, Josh and Goldstein, Ted and Salama, Sofie and Deyell, Rebecca and Rassekh, S. Rod and Haussler, David
2016

Hypotension associated with ingestion of cannabinoids in two children with cancer
Canadian Medical Association Journal
Li, Amanda M. and Rassekh, S. Rod
DOI: 10.1503/cmaj.150847
2016

Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers
Therapeutic Drug Monitoring
Lee, Jong W. and Pussegoda, Kusala and Rassekh, Shahrad R. and Monzon, Jose G. and Liu, Geoffrey and Hwang, Soomi and Bhavsar, Amit P. and Pritchard, Sheila and Ross, Colin J. and Amstutz, Ursula and Carleton, Bruce C. and CPNDS Clinical Recommendations Grp
DOI: 10.1097/FTD.0000000000000298
2016

Pharmacogenomic Strategies for the Prevention of Anthracycline-Induced Heart Failure: Validation of a Genetic Association with a Non-Synonymous Variant in RARG
Pediatric Blood & Cancer
Bhavsar, A. P. and Rassekh, S. R. and Aminkeng, F. and Li, Y. and Gunaretnam, E. and Rieder, M. J. and Bernstein, D. and Hayden, M. R. and Carleton, B. C. and Ross, C. J. D.
2016

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity
British Journal of Clinical Pharmacology
Aminkeng, Folefac and Ross, Colin J. D. and Rassekh, Shahrad R. and Hwang, Soomi and Rieder, Michael J. and Bhavsar, Amit P. and Smith, Anne and Sanatani, Shubhayan and Gelmon, Karen A. and Bernstein, Daniel and Hayden, Michael R. and Amstutz, Ursula and Carleton, Bruce C. and CPNDS Clin Practice
DOI: 10.1111/bcp.13008
2016

When Parents Refuse Potentially Curative Treatment for their Child's Cancer - Does Legal Intervention Improve Outcome?
Pediatric Blood & Cancer
Burns, C. and Rassekh, S. R. and Corbett, R. and MacFarlane, S. and Sullivan, M.
2016

Clinical Implimentation of a Pharmacogenetic Risk Prediction Model for Cisplatin Ototoxicity and Anthracycline Cardiotoxicity
Pediatric Blood & Cancer
Rassekh, S. R. and Ross, C. J. D. and Groeneweg, G. and Bhavsar, A. P. and Aminkeng, F. and Bendyshe-Walton, T. and Miao, F. and Hill, M. and Massah, N. and Hildebrand, C. and Carleton, B. C.
2016

OUTCOMES FOR YOUNG CHILDREN WITH BRAIN TUMOURS TREATED ACCORDING TO THE HEAD START PROTOCOLS: A SINGLE-CENTRE EXPERIENCE
Neuro-Oncology
Szpurko, Ashley and O'Halloran, Katrina and Potts, Jim and Dunham, Christopher and Goddard, Karen and Davis, Jeffrey and Strahlendorf, Caron and Rassekh, Shahrad Rod and Hukin, Juliette
2016

PEDIATRIC PERSONALIZED ONCOGENOMICS (PEDSPOG) - INITIAL OUTCOMES
Pediatric Blood & Cancer
Rassekh, Shahrad and Deyell, Rebecca and Shen, Yaoqing and Lee, Anna and Dunham, Chris and Virani, Alice and Armstrong, Linlea and Morin, Ryan and Yip, Stephen and Pleasance, Erin and Jones, Martin and Schein, Jacqueline and Mungall, Andrew and Zhao, Yongjun and Moore, Richard and Ma, Yussanne and Jones, Steven and Laskin, Janessa and Marra, Marco
2015

A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Nature Genetics
Aminkeng, Folefac and Bhavsar, Amit P. and Visscher, Henk and Rassekh, Shahrad R. and Li, Yuling and Lee, Jong W. and Brunham, Liam R. and Caron, Huib N. and van Dalen, Elvira C. and Kremer, Leontien C. and van der Pal, Helena J. and Amstutz, Ursula and Rieder, Michael J. and Bernstein, Daniel and Carleton, Bruce C. and Hayden, Michael R. and Ross, Colin J. D. and Canadian Pharmacogenomics Network
DOI: 10.1038/ng.3374
2015

Characterizing standardized uptake values on diagnostic PET/CT scans according to pediatric lymphoma subtypes
Journal of Nuclear Medicine
Halparin, Jessica and Rassekh, Shahrad and Nadel, Helen
2015

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children
Pharmacogenomics
Visscher, Henk and Rassekh, S. Rod and Sandor, George S. and Caron, Huib N. and van Dalen, Elvira C. and Kremer, Leontien C. and van der Pal, Helena J. and Rogers, Paul C. and Rieder, Michael J. and Carleton, Bruce C. and Hayden, Michael R. and Ross, Colin J. and CPNDS Consortium
DOI: 10.2217/PGS.15.61
2015

Management of germline findings revealed throughout the course of tumor-normal whole genome sequencing in oncology
European Journal of Cancer
Lim, H. and Schrader, K. and Young, S. and Fok, A. and Pleasance, E. and Jones, M. and Shen, Y. and Armstrong, L. and Virani, A. and Rassekh, S. and Deyell, R. and Yip, S. and Roscoe, R. and Karsan, A. and Marra, M. and Laskin, J.
2015

Whole genome analysis in a population-based cancer system: Results from sequencing > 100 metastatic cancer patients
European Journal of Cancer
Lim, H. and Renouf, D. and Sun, S. and Ho, C. and Gelmon, K. and Chia, S. and Pleasance, E. and Jones, M. and Shen, Y. and Eirew, P. and Rassekh, S. and Deyell, R. and Yip, S. and Huntsman, D. and Roscoe, R. and Fok, A. and Ma, Y. and Jones, S. and Marra, M. and Laskin, J.
2015

RISK AND PATTERNS OF UTILIZATION OF COMMUNITY CARE AND MENTAL HEALTH SERVICES AMONG CHILDHOOD, ADOLESCENT AND YOUNG ADULT CANCER SURVIVORS IN BRITISH COLUMBIA, CANADA
Pediatric Blood & Cancer
McBride, M. and Li, D. and Goddard, K. and Pritchard, S. and Rassekh, S. R. and Sheps, S.
2014

VKORC1 and CYP2C9 Genotypes are Predictors of Warfarin-Related Outcomes in Children
Pediatric Blood & Cancer
Shaw, Kaitlyn and Amstutz, Ursula and Hildebrand, Claudette and Rassekh, S. Rod and Hosking, Martin and Neville, Kathleen and Leeder, J. Steven and Hayden, Michael R. and Ross, Colin J. and Carleton, Bruce C.
DOI: 10.1002/pbc.24932
2014

POLO-LIKE KINASE 1 (PLK1) ACTIVATES TRANSLATIONALLY CONTROLLED TUMOR PROTEIN (TCTP) PROMOTING THE DEVELOPMENT OF REFRACTORY MEDULLOBLASTOMA
Neuro-Oncology
Triscott, Joanna and Green, Marcus and Foster, Colleen and Fotovati, Abbas and Berns, Rachel and O'Halloran, Katrina and Singhal, Ash and Hukin, Juliette and Rassekh, S. Rod and Yip, Stephen and Toyota, Brian and Dunham, Christopher and Dunn, Sandra E.
2014

PERSONALIZING THE TREATMENT OF PEDIATRIC MEDULLOBLASTOMA: POLO-LIKE KINASE 1 AS A MOLECULAR TARGET IN HIGH-RISK CHILDREN
Neuro-Oncology
Sheila, Cathy and Lee, Singh and Foster, Colleen and Manoranjan, Branavan and Pambit, Mary and Berns, Rachel and Fotovati, Abbas and Venugopal, Chitra and O'Halloran, Katherine and Narendran, Arul and Hawkins, Cynthia and Ramaswamy, Vijay and Bouffet, Eric and Taylor, Michael and Singhal, Ash and Hukin, Juilette and Rassekh, Rod and Yip, Stephen and Northcott, Paul and Singh, Sheila and Duhman, Chris and Dunn, Sandra
2014

Intra-Arterial Methylprednisolone for Severe Steroid Refractory Gastrointestinal Graft-Versus-Host Disease
Pediatric Blood & Cancer
Bhuller, Kaljit S. and Heran, Manraj K. S. and Wu, John K. M. and Rassekh, S. Rod
DOI: 10.1002/pbc.25155
2014

Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent
Pharmacogenomics Journal
Aminkeng, F. and Ross, C. J. D. and Rassekh, S. R. and Brunham, L. R. and Sistonen, J. and Dube, M-P and Ibrahim, M. and Nyambo, T. B. and Omar, S. A. and Froment, A. and Bodo, J-M and Tishkoff, S. and Carleton, B. C. and Hayden, M. R. and Canadian Pharmacogenomics Network
DOI: 10.1038/tpj.2013.13
2014

Guideline for Primary Antifungal Prophylaxis for Pediatric Patients With Cancer or Hematopoietic Stem Cell Transplant Recipients
Pediatric Blood & Cancer
Science, Michelle and Robinson, Paula D. and MacDonald, Tamara and Rassekh, Shahrad Rod and Dupuis, L. Lee and Sung, Lillian
DOI: 10.1002/pbc.24847
2014

Growing teratoma syndrome in intracranial non-germinomatous germ cell tumors (iNGGCTs): a risk for secondary malignant transformation-a report of two cases
Childs Nervous System
Glass, Torin and Cochrane, D. Douglas and Rassekh, Shahrad Rod and Goddard, Karen and Hukin, Juliette
DOI: 10.1007/s00381-013-2295-1
2014

GENETIC VARIANTS IN SLC22A17 AND SLC22A7 ARE ASSOCIATED WITH ANTHRACYCLINE-INDUCED CARDIOTOXICITY IN CHILDREN
Pediatric Blood & Cancer
Visscher, H. and Ross, C. J. and Rassekh, S. R. and Sandor, G. S. and Caron, H. N. and van Dalen, E. C. and van der Pal, H. J. and Kremer, L. C. and Carleton, B. C. and Hayden, M. R.
2014

Genetic Markers of Cisplatin-Induced Hearing Loss in Children
Clinical Pharmacology & Therapeutics
Carleton, B. C. and Ross, C. J. and Pussegoda, K. and Bhavsar, A. P. and Visscher, H. and Lee, J. W. and Brooks, B. and Rassekh, S. R. and Dube, M-P P. and Hayden, M. R.
DOI: 10.1038/clpt.2014.92
2014

Diagnostic Value of Next-Generation Sequencing in an Unusual Sphenoid Tumor
Oncologist
Jamshidi, Farzad and Pleasance, Erin and Li, Yvonne and Shen, Yaoqing and Kasaian, Katayoon and Corbett, Richard and Eirew, Peter and Lum, Amy and Pandoh, Pawan and Zhao, Yongjun and Schein, Jacqueline E. and Moore, Richard A. and Rassekh, Rod and Huntsman, David G. and Knowling, Meg and Lim, Howard and Renouf, Daniel J. and Jones, Steven J. M. and Marra, Marco A. and Nielsen, Torsten O. and Laskin, Janessa and Yip, Stephen
DOI: 10.1634/theoncologist.2013-0390
2014

CHARACTERIZING STANDARDIZED UPTAKE VALUES ON DIAGNOSTIC PET/CT SCANS ACCORDING TO PEDIATRIC LYMPHOMA SUBTYPES
Pediatric Blood & Cancer
Halparin, J. and Rassekh, S. R. and Nadel, H. R.
2014

ASSESSING THE ACCURACY OF DEATH RECORDS AND PRE-MORTEM CLINICAL DIAGNOSES: A RETROSPECTIVE CHART REVIEW OF DECEASED CHILDREN DIAGNOSED WITH BRAIN TUMOURS IN BRITISH COLUMBIA, CANADA
Pediatric Blood & Cancer
Hasan, H. and Hendson, G. and Howard, F. and Rassekh, R. and Hukin, J. and Dunham, C. and Ahmed, T. and Lo, A. and Bradley, N. and Goddard, K.
2014

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity
Clinical Pharmacology & Therapeutics
Carleton, B. C. and Ross, C. J. and Bhavsar, A. P. and Amstutz, U. and Pussegoda, K. and Visscher, H. and Lee, J. W. and Brooks, B. and Rassekh, S. R. and Dube, M-P and Hayden, M. R.
DOI: 10.1038/clpt.2013.219
2014

Vincristine and fine motor function of children with acute lymphoblastic leukemia
Canadian Journal of Occupational Therapy-Revue Canadienne D Ergotherapie
Sabarre, Cheryl L. and Rassekh, Shahrad R. and Zwicker, Jill G.
DOI: 10.1177/0008417414539926
2014

Response to "Evaluation of Pharmacogenetic Markers to Predict the Risk of Cisplatin-Induced Ototoxicity"
Clinical Pharmacology & Therapeutics
Carleton, B. C. and Ross, C. J. and Bhavsar, A. P. and Lee, J. W. and Visscher, H. and Rassekh, S. R. and Hayden, M. R.
DOI: 10.1038/clpt.2014.90
2014

THE Y-BOX BINDING PROTEIN-1 CONVEYS TEMOZOLOMIDE RESISTANCE BY THE INHIBITING DNA DAMAGE RESPONSE PATHWAY THROUGH THE POLYCOMB REPRESSOR BMI-1
Neuro-Oncology
Fotovati, Abbas and Radiloff, Daniel and Coute, Nicole and Triscott, Joanna and Chen, James and Yip, Stephen and Louis, David and Toyota, Brian and Hukin, Juliette and Rassekh, S. Rod and Singhal, Ash and Dunham, Chris and Dunn, Sandra
2013

Replication of TPMT and ABCC3 Genetic Variants Highly Associated With Cisplatin-Induced Hearing Loss in Children
Clinical Pharmacology & Therapeutics
Pussegoda, K. and Ross, C. J. and Visscher, H. and Yazdanpanah, M. and Brooks, B. and Rassekh, S. R. and Zada, Y. F. and Dube, M-P and Carleton, B. C. and Hayden, M. R. and CPNDS Consortium
DOI: 10.1038/clpt.2013.80
2013

Prenatal Presentation of Fronto-orbital Congenital Infantile Fibrosarcoma: A Clinicopathologic Report
Jama Ophthalmology
Tsang, Hughie H. and Dolman, Peter J. and Courtemanche, Douglas J. and Rassekh, Shahrad Rod and Senger, Christof and Lyons, Christopher J.
DOI: 10.1001/jamaophthalmol.2013.1934
2013

Predicting Anthracycline-induced Cardiotoxicity in Children - Genome-Wide Association Study
Faseb Journal
Aminkeng, Folefac and Ross, Colin J. D. and Rassekh, Rod S. and Brunham, Liam R. and Weissman, Cory and Dube, Marie-Pierre and Visscher, Henk and Rieder, Michael J. and Carleton, Bruce C. and Hayden, Michael R.
2013

PHARMACOGENOMICS OF VINCRISTINE-INDUCED NEUROTOXICITY IN PEDIATRIC CANCER PATIENTS
Pediatric Blood & Cancer
Rassekh, S. and Amstutz, U. and Loo, T. and Gylling, H. and Zada, Y. Feroz and Dube, M. and Hukin, J. and Hayden, M. and Ross, C. and Carleton, B.
2013

Pharmacogenomics of vincristine-induced neurotoxicity in pediatric cancer patients
Faseb Journal
Amstutz, Ursula and Loo, Tenneille T. and Gylling, Helene M. and Rassekh, Rod and Hukin, Juliette and Zada, Yassamin Faroz and Dube, Marie-Pierre and Brown, Andrew M. and Phillips, Michael S. and Hayden, Michael R. and Ross, Colin J. and Carleton, Bruce C.
2013

Pharmacogenetics of warfarin safety and effectiveness in children
Faseb Journal
Shaw, Kaitlyn and Amstutz, Ursula and Hildebrand, Claudette and Rassekh, S. Rod and Dube, Marie-Pierre and Hayden, Michael R. and Ross, Colin J. and Carleton, Bruce C.
2013

Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children
Cancer Research
Triscott, Joanna and Lee, Cathy and Foster, Colleen and Manoranjan, Branavan and Pambid, Mary Rose and Berns, Rachel and Fotovati, Abbas and Venugopal, Chitra and O'Halloran, Katrina and Narendran, Aru and Hawkins, Cynthia and Ramaswamy, Vijay and Bouffet, Eric and Taylor, Michael D. and Singhal, Ash and Hukin, Juliette and Rassekh, Rod and Yip, Stephen and Northcott, Paul and Singh, Sheila K. and Dunham, Christopher and Dunn, Sandra E.
DOI: 10.1158/0008-5472.CAN-12-4331
2013

PERSONALIZING THE TREATMENT FOR MEDULLOBLASTOMA: POLO-LIKE KINASE 1 (PLK1) AS A MOLECULAR TARGET FOR THE SONIC HEDGEHOG (SHH) SUBTYPE
Neuro-Oncology
Lee, Cathy and Triscott, Joanna and Foster, Colleen and Manoranjan, Branavan and Pambid, Mary Rose and Fotovati, Abbas and Berns, Rachel and Venugopal, Chitra and O'Halloran, Katherine and Narendran, Aru and Northcott, Paul and Taylor, Michael D. and Singh, Sheila K. and Singhal, Ash and Rassekh, Rod and Maxwell, Christopher A. and Dunham, Christopher and Dunn, Sandra E.
2013

Outcome of infants and young children with newly diagnosed ependymoma treated on the "Head Start" III prospective clinical trial
Journal of Neuro-Oncology
Venkatramani, Rajkumar and Ji, Lingyun and Lasky, Joseph and Haley, Kelley and Judkins, Alexander and Zhou, Shengmei and Sposto, Richard and Olshefski, Randal and Garvin, James and Tekautz, Tanya and Kennedy, Gloria and Rassekh, Shahrad Rod and Moore, Theodore and Gardner, Sharon and Allen, Jeffrey and Shore, Richard and Moertel, Christopher and Atlas, Mark and Dhall, Girish and Finlay, Jonathan
DOI: 10.1007/s11060-013-1111-9
2013

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy (vol 41, pg 1345, 2009)
Nature Genetics
Ross, Colin J. D. and Katzov-Eckert, Hagit and Dube, Marie-Pierre and Brooks, Beth and Rassekh, S. Rod and Barhdadi, Amina and Feroz-Zada, Yassamin and Visscher, Henk and Brown, Andrew M. K. and Rieder, Michael J. and Rogers, Paul C. and Phillips, Michael S. and Carleton, Bruce C. and Hayden, Michael R. and CPNDS Consortium
DOI: 10.1038/ng.0513-578
2013

Cancer Pharmacogenomics in Children: Research Initiatives and Progress to Date
Pediatric Drugs
Rassekh, Shahrad Rod and Ross, Colin J. D. and Carleton, Bruce C. and Hayden, Michael R.
DOI: 10.1007/s40272-013-0021-9
2013

Antidepressant use among survivors of childhood, adolescent and young adult cancer: A report of the childhood, adolescent and young adult cancer survivor (CAYACS) research program
Pediatric Blood & Cancer
Deyell, Rebecca J. and Lorenzi, Maria and Ma, Suli and Rassekh, Shahrad R. and Collet, Jean-Paul and Spinelli, John J. and McBride, Mary L.
DOI: 10.1002/pbc.24446
2013

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children
Pediatric Blood & Cancer
Visscher, H. and Ross, C. J. D. and Rassekh, S. R. and Sandor, G. S. S. and Caron, H. N. and van Dalen, E. C. and Kremer, L. C. and van der Pal, H. J. and Rogers, P. C. and Rieder, M. J. and Carleton, B. C. and Hayden, M. R. and CPNDS Consortium
DOI: 10.1002/pbc.24505
2013

Economic impact of a genetic test for cisplatin-induced ototoxicity
Pharmacogenomics Journal
Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.
DOI: 10.1038/tpj.2011.15
2012

CHARACTERISTICS OF HIGH HEALTH CARE USERS AMONG CHILDHOOD, ADOLESCENT AND YOUNG ADULT CANCER SURVIVORS IN BRITISH COLUMBIA, CANADA
Pediatric Blood & Cancer
Rogers, Paul and Lorenzi, Maria and Tsonis, Miranda and Goddard, Karen and Pritchard, Sheila and Rassekh, Shahrad Rod and Sheps, Sam and McBride, Mary L.
2012

Atypical Teratoid Rhabdoid Tumors (ATRTs): The British Columbia's Children's Hospital's Experience, 1986-2006
Brain Pathology
Fleming, Adam J. and Hukin, Juliette and Rassekh, Rod and Fryer, Christopher and Kim, James and Stemmer-Rachamimov, Anat and Birks, Diane K. and Huang, Annie and Yip, Stephen and Dunham, Christopher
DOI: 10.1111/j.1750-3639.2011.00561.x
2012

Economic impact of a genetic test for cisplatin-induced ototoxicity (vol 12, pg 205, 2011)
Pharmacogenomics Journal
Dionne, F. and Mitton, C. and Rassekh, R. and Brooks, B. and Ross, C. and Hayden, M. and Carleton, B.
DOI: 10.1038/tpj.2011.21
2012

GENETIC PREDISPOSITION TO ADVERSE EVENTS
Pediatric Blood & Cancer
Rassekh, Shahrad Rod
2012

Possible differentiation of cerebral glioblastoma into pleomorphic xanthoastrocytoma: an unusual case in an infant Case report
Journal of Neurosurgery-Pediatrics
Yang, Michael M. H. and Singhal, Ash and Rassekh, Shahrad Rod and Yip, Stephen and Eydoux, Patrice and Dunham, Christopher
DOI: 10.3171/2012.1.PEDS11326
2012

OUTCOMES OF CHILDREN TREATED WITH A CHEMOTHERAPY-ONLY INFANT PROTOCOL AT BRITISH COLUMBIA'S CHILDREN'S HOSPITAL
Neuro-Oncology
O'Halloran, Katrina and Hukin, Juliette and Singhal, Ash and Dunham, Chris and Goddard, Karen and Rassekh, Shahrad R.
2012

Pharmacogenetics of Warfarin in Children
Pharmacoepidemiology and Drug Safety
Shaw, Kaitlyn and Amstutz, Ursula and Hildebrand, Claudette and Rassekh, S. Rod and Ross, Colin J. and Hayden, Michael R. and Carleton, Bruce C.
2012

Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children
Journal of Clinical Oncology
Visscher, Henk and Ross, Colin J. D. and Rassekh, S. Rod and Barhdadi, Amina and Dube, Marie-Pierre and Al-Saloos, Hesham and Sandor, George S. and Caron, Huib N. and van Dalen, Elvira C. and Kremer, Leontien C. and van der Pal, Helena J. and Brown, Andrew M. K. and Rogers, Paul C. and Phillips, Michael S. and Rieder, Michael J. and Carleton, Bruce C. and Hayden, Michael R. and Canadian Pharmacogenomics Network
DOI: 10.1200/JCO.2010.34.3467
2012

Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale
Journal of Clinical Oncology
Brock, Penelope R. and Knight, Kristin R. and Freyer, David R. and Campbell, Kathleen C. M. and Steyger, Peter S. and Blakley, Brian W. and Rassekh, Shahrad R. and Chang, Kay W. and Fligor, Brian J. and Rajput, Kaukab and Sullivan, Michael and Neuwelt, Edward A.
DOI: 10.1200/JCO.2011.39.1110
2012

MALIGNANT TRANSFORMATION OF GROWING TERATOMAS: A GROWING PHENOMENON
Neuro-Oncology
Glass, Torin and Cochrane, D. Douglas and Rassekh, Shahrad Rod and Goddard, Karen and Hukin, Juliette
2012

LATE MORBIDITY AS MEASURED BY HOSPITAL ADMISSIONS AMONG SURVIVORS OF CHILDHOOD WILMS TUMORS
Pediatric Blood & Cancer
Goddard, Karen and Mcbride, Mary and Lorenzi, Maria and Rassekh, Rod
2011

HIGH INCIDENCE OF FUNGAL INFECTIONS IN PEDIATRIC ONCOLOGY PATIENTS IN BRITISH COLUMBIA
Pediatric Blood & Cancer
Rassekh, Shahrad Rod and Ratzlafl, Matthew and Al-Dahhagh, Mona and Lloyd, Claire and Damphousse, Amelie and Jamieson, Douglas and AI-Rawahi, Ghada and Kaman, Tobias R.
2011

FINAL REPORT ON OUTCOME OF CHILDREN WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA (HGG) TREATED WITH MULTI-DRUG INDUCTION CHEMOTHERAPY FOLLOWED BY CONSOLIDATIVE MYELOABLATIVE CHEMOTHERAPY AND AUTOLOGOUS HEMATOPOIETIC PROGENITOR CELL RESCUE (AuHPCR) ON THE "HEAD START" II AND III PROTOCOLS
Neuro-Oncology
Espinoza, Juan and Haley, Kelley and Patel, Neha and Dhall, Girish and Gardner, Sharon and Jeffrey, Allen and Torkildson, Joseph and Cornelius, Albert and Rassekh, Rod and Bedros, Antranik and Etzl, Morris and Garvin, James and Pradhan, Kamnesh and Corbett, Robin and Sullivan, Michael and McGowage, Geoffrey and Puccetti, Diane and Stein, Dagmar and Jasty, Rama and Ji, Lingyun and Sposto, Richard and Finlay, Jonathan L.
2011

Nephrotic syndrome developing during induction chemotherapy for childhood acute lymphoblastic leukemia
Clinical and Experimental Nephrology
Prestidge, Chanel and Rassekh, Shahrad Rod and Matsell, Douglas G.
DOI: 10.1007/s10157-010-0401-1
2011

SEVERE GENITAL ULCERATION IN AN ACUTE EPSTEIN-BARR VIRUS INFECTION
Pediatric Infectious Disease Journal
Al-Rawahi, Ghada N. and Dobson, Simon R. and Scheifele, David W. and Rassekh, S. Rod and Murphy, James J.
DOI: 10.1097/INF.0b013e3181f41b2e
2011

Pathology, genetics and cytogenetics of Wilms' tumour
Pathology
Md Zin, R. and Murch, A. and Charles, A.
DOI: 10.1097/PAT.0b013e3283463575
2011

OUTCOME OF INFANTS AND YOUNG CHILDREN WITH NEWLY DIAGNOSED EPENDYMOMA TREATED ON "HEAD START" III PROTOCOL
Neuro-Oncology
Venkatramani, Rajkumar and Haley, Kelley and Gilles, Floyd and Sposto, Richard and Ji, Lingyun and Olshefski, Randal and Garvin, James and Tekautz, Tanya and Kennedy, Gloria and Rassekh, Rod and Moore, Theodore and Gardner, Sharon and Allen, Jeffrey and Shore, Richard and Moertel, Chris and Atlas, Mark and Lasky, Joseph and Finlay, Jonathan
2011

Outcome of Head Start III multinational protocol for newly diagnosed central nervous system (CNS) primitive neuroectodermal tumors (pnet) of young children.
Journal of Clinical Oncology
Davidson, T. B. and Ji, L. and Haley, K. and Dhall, G. and Grimm, J. P. and Gilles, F. H. and Gardner, S. L. and Allen, J. C. and Bedros, A. A. and Etzl, M. M. and Olshefski, R. S. and Cornelius, A. and Torkildson, J. and Kennedy, G. A. and Fangusaro, J. R. and Rassekh, S. R. and Joyce, M. J. and Bertolone, S. J. and Sposto, R. and Finlay, J. L.
2011

Abnormal Liver Transaminases and Conjugated Hyperbilirubinemia at Presentation of Acute Lymphoblastic Leukemia
Pediatric Blood & Cancer
Segal, I and Rassekh, SR and Bond, MC and Senger, C and Schreiber, RA
DOI: 10.1002/pbc.22549
2010

CASE-BASED INTERACTIVE E-LEARNING PROGRAMS FOR PEDIATRIC ONCOLOGY: RATIONALE, DEVELOPMENT AND USER EVALUATION RESULTS
Pediatric Blood & Cancer
Goddard, Karen and Brown, Tanya and Hukin, Juliette and DeZorzi, Pia and Johnston, Donna and Punnett, Angela and Rassekh, Shawn and Shaikh, Furqan and Olson, Rob
2010

Childhood, Adolescent, and Young Adult Cancer Survivors Research Program of British Columbia: Objectives, Study Design, and Cohort Characteristics
Pediatric Blood & Cancer
McBride, ML and Rogers, PC and Sheps, SB and Glickman, V and Broemeling, AM and Goddard, K and Hu, JA and Lorenzi, M and Peacock, S and Pritchard, S and Rassekh, SR and Siegel, L and Spinelli, JJ and Teckle, P and Xie, LJ
DOI: 10.1002/pbc.22476
2010

HEALTH CARE PROVIDERS' VIEWS OF INFORMED CONSENT AND JOINT DECISION MAKING IN PEDIATRIC PATIENTS WITH BRAIN TUMOURS
Pediatric Blood & Cancer
Olson, Robert and Hukin, Juliette and Steenburgh, Suzanne and Rassekh, Rod and Ho, Anita and Bobinski, Mary Anne and Goddard, Karen
2010

LACK OF CISPLATIN INDUCED HEARING LOSS AS A PREDICTOR OF A POOR OUTCOME IN CHILDREN WITH OSTEOSARCOMA
Pediatric Blood & Cancer
Rassekh, Shahrad Rod and Dedhar, Alysha and Brooks, Beth and Senger, Christof and MCCaffrey, Lindsay and Brown, Kenneth and Carleton, Bruce and Hayden, Michael and Kozak, Frederick
2010

RESECTION ALONE IN LIEU OF ADJUVANT THERAPY IN THE TREATMENT OF MEDULLOBLASTOMA IN GORLIN SYNDROME
Neuro-Oncology
Rasmussen, L and Hukin, J and Rassekh, SR and Singhal, A and Hendson, G
2010

REDEFINING THE INCIDENCE, OUTCOMES, AND PROGNOSTIC FACTORS FOR CNS ATYPICAL TERATOID RHABDOID TUMOURS AT BC CHILDREN'S HOSPITAL
Neuro-Oncology
Fleming, AJ and Hukin, J and Rassekh, SR and Fryer, CJH and Yip, S and Dunham, C
2010

REDEFINING THE INCIDENCE AND OUTCOMES OF CNS ATYPICAL TERATOID RHABDOID TUMOURS AT BC CHILDREN'S HOSPITAL
Pediatric Blood & Cancer
Fleming, A and Hukin, J and Rassekh, SR and Fryer, C and Dunham, C
2010

PROGNOSTIC FACTORS INFLUENCING SURVIVAL FOR CNS ATYPICAL TERATOID RHABDOID TUMORS IN BRITISH COLUMBIA
Pediatric Blood & Cancer
Fleming, Adam and Hukin, Juliette and Rassekh, S. Rod and Fryer, Chris and Yip, Stephen and Dunham, Christopher
2010

OTOTOXICITY AS A PREDICTOR OF OUTCOME IN PATIENTS WITH OSTEOSARCOMA TREATED WITH CISPLATIN
Pediatric Blood & Cancer
Rassekh, SR and Dedhar, A and Brooks, B and Senger, C and McCaffrey, L and Brown, K and Kozak, F
2010

OTOTOXICITY AS A PREDICTOR OF OUTCOME IN OSTEOSARCOMA PATIENTS TREATED WITH CISPLATIN
Journal of Investigative Medicine
Dedhar, A. and Brooks, B. and Senger, C. and Kozac, F. and Rassekh, R.
2010

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
Nature Genetics
Ross, CJD and Katzov-Eckert, H and Dube, MP and Brooks, B and Rassekh, SR and Barhdadi, A and Feroz-Zada, Y and Visscher, H and Brown, AMK and Rieder, MJ and Rogers, PC and Phillips, MS and Carleton, BC and Hayden, MR
DOI: 10.1038/ng.478
2009

IDENTIFICATION OF GENETIC MARKERS OF SEVERE HEARING LOSS IN CHILDREN RECEIVING CISPLATIN
Pediatric Blood & Cancer
Rassekh, Rod and Ross, Colin and Brooks, Beth and Katzov, Hagit and Dube, Marie-Pierre and Carleton, Bruce and Hayden, Michael and Rogers, Paul
2009

In Vitro Inferiority of Ceftazidime Compared With Other beta-lactams for Viridans Group Streptococcus Bacteremia in Pediatric Oncology Patients Implications for Antibiotic Choices
Journal of Pediatric Hematology Oncology
Paulus, S and Dobson, S and Rassekh, S and Hill, EB
2009

Inflammatory Myofibroblastic Tumour of the Subglottis in a 5-Year-Old
Journal of Otolaryngology-Head & Neck Surgery
Hartl, T and Moxham, JP and Ludemann, JP and Rassekh, SR
DOI: 10.2310/7070.2009.080211
2009

Late hospitalizations among survivors of pediatric brain tumors
Neuro-Oncology
Rassekh, SR and Goddard, K and Lorenzi, M and Xie, LJ and Page, J and Lee, L and Mcbride, M
2008

Screening for submicroscopic chromosomal rearrangements in Wilms tumor using whole-genome microarrays
Cancer Genetics and Cytogenetics
Rassekh, SR and Chan, S and Harvard, C and Dix, D and Qiao, Y and Rajcan-Separovic, E
DOI: 10.1016/j.cancergencyto.2007.12.015
2008

Canadian national active surveillance network for adverse drug reactions: Genotypic approaches to therapy in children (GATC): The first year
Pharmacoepidemiology and Drug Safety
Carleton, B. C. and Warn, D. and Stenton, S. and Rassekh, R. and Smith, M. A. and Dhami, B. and Ross, C. and Hayden, M. R.
2007

Genotypic approaches to therapy in children - A national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children
Autoimmunity, Pt B: Novel Applications of Basic Research
Ross, CJD and Carleton, B and Warn, DG and Stenton, SB and Rassekh, SR and Hayden, MR
DOI: 10.1196/annals.1423.020
2007

A roadmap for engaging first nations communities in medical research.
Journal of Investigative Medicine
Rassekh, R and Miller, K and Louie, P and Benton, D and Macnab, A
2004

Adults with myelomeningocele: Functional outcome of the last 5 years of graduates from a children's hospital
Journal of Investigative Medicine
Rassekh, SR and Thiessen, PN and Irwin, BJ and Chambers, K
2003

Promoting healthy food choices among children in first nations communities.
Journal of Investigative Medicine
Louie, P and Tandan, T and Rassekh, R and Clarke, M and Duffy, D and Macnab, A
2003

Validity and reliability of a pediatric pneumonia score
Journal of Investigative Medicine
Hirsh, D and Rassekh, R and Appelt, G and Macnab, A
2003

Functional deterioration following placode untethering in myelomeningocele
Pediatric Neurosurgery
Cochrane, DD and Rassekh, SR and Thiessen, PN
1998

Research

Genotype-Specific Approaches to Therapy in Children with Cancer (GATC Cancer Study)
Adverse events due to medications are a common complication of the treatment of childhood cancer. This study is attempting to identify genetic risk factors that may be associated with adverse drug events. We have designed a case-control study to investigate all adverse events, with an initial focus on anthracycline-induced cardiomyopathy and cisplatin induced hearing loss.
Through a partnership with Drs Michael Hayden and Bruce Carleton, and a 2 year grant from the C17 Research Network, we have made this study available to 17 hospitals.

Grants

Michael Cuccione Childhood Cancer Research Program Brain Tumour Grant, start up funding - Project: “Outcomes in brain tumors treated with a chemotherapy only approach”

Honours & Awards

Outstanding Junior Resident (July 2001)

Outstanding Resident Researcher Award (June 2002)