Uthaya Kumaran Kanagaraj
MD, GDCE
Investigator, BC Children's Hospital
Neonatologist, BC Women's Hospital + Health Centre
Pediatrics & Neonatology
Uthaya Kumaran Kanagaraj and Mimi T.Y. Kuan and Michael Castaldo and Erik Skarsgard and Joseph Y. Ting
DOI: 10.1016/j.pedneo.2025.11.01101 / 2026
Journal of Clinical Medicine
UTHAYA KUMARAN and Tapas Kulkarni and Eddie Kwan and Qian Zhang and Jeffery Bone and Sandesh Shivananda
DOI: 10.3390/jcm1403069601 / 2025
Journal of Neonatology
Kumaran, U. and Shenoi, A.
DOI: 10.1177/09732179221084669Journal of Paediatrics and Child Health
Uthaya Kumaran and Seema Gaonkar and Maitri Chaudhuri and Ajmeer K Sheriff and Nilesh Rao and Malathi Raja and Arvind Shenoi
DOI: 10.1111/jpc.1539112 / 2021
Journal of Neonatology
Uthaya Kumaran and Arvind Shenoi
DOI: 10.1177/097321792199938303 / 2021
Indian Journal of Pediatrics
Kartheeka, M.G. and Kumaran, U. and Rao, N.N. and Raja, M. and Shenoi, P. and Shenoi, A.
DOI: 10.1007/s12098-020-03552-0This study evaluated the performance of the updated NICHD BPD Outcome Estimator in predicting bronchopulmonary dysplasia (BPD) or death among extremely preterm infants cared for in a Canadian quaternary NICU. By analyzing serial risk estimates at multiple time points (days 1, 3, 7, 14, and 28) in infants born before 29 weeks, we found the model demonstrated good accuracy from the end of the first week of life (AUC > 0.8). The findings support the use of this tool in clinical discussions and early intervention planning for high-risk infants, while emphasizing the importance of local validation before widespread adoption.
Accurate echocardiographic assessment is essential for understanding cardiovascular adaptation in preterm infants. In this project, we compared two echocardiographic techniques—two-dimensional (2D) and M-mode—for two key cardiac indices: the left atrium to aortic root diameter ratio (LA:Ao) and fractional shortening (FS). We found that LA:Ao showed high reliability across both methods (ICC ˜ 0.87), while FS demonstrated only moderate reproducibility (ICC ˜ 0.72–0.73). These results suggest LA:Ao may serve as a more consistent measure of cardiac loading conditions in extremely preterm infants, underscoring the need for standardized imaging protocols and training in neonatal echocardiography.
This 10-year retrospective study examined postnatal steroid (PNS) practices for BPD prevention and treatment in infants born before 33 weeks’ gestation. Among over 2,000 admissions, 8% of infants received steroids—most commonly dexamethasone—initiated around day 29 for a median of 10 days. While overall use remained stable, cumulative steroid exposure per infant increased, and nearly half of treatment courses deviated from standardized regimens. The findings highlight evolving local practices, the need for consistent adherence to evidence-based protocols, and the importance of monitoring both short- and long-term outcomes associated with PNS exposure.
Co-Principal Investigator. Reliability of Two-Dimensional versus M-Mode Echocardiography for Measurement of Left Atrium/Aortic Diameter Ratio and Fractional Shortening in Extremely Preterm Infants. Funding Source: BCCHR E2i Seed Grant
2025 - Outstanding Achievement Award, Sub-specialty Resident or Fellow, BC Children’s Hospital Research Institute
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