Overview

I work with patients with medical complications in pregnancy, but specifically in the area of Venous Thromboembolism in Pregnancy.

Publications

Diagnosis of venous thromboembolism in pregnancy
Thrombosis Research
Wee-Shian Chan
DOI: 10.1016/j.thromres.2017.09.003
09/2017

Maternal age and severe maternal morbidity: A population-based retrospective cohort study
PLOS Medicine
Sarka Lisonkova, Jayson Potts, Giulia M. Muraca, Neda Razaz, Yasser Sabr, Wee-Shian Chan, Michael S. Kramer
DOI: 10.1371/journal.pmed.1002307
05/2017

Low-molecular-weight heparin to prevent postpartum venous thromboembolism. A pilot randomised placebo-controlled trial
Thrombosis and Haematosis
PubMed: 25373438
01/2015

Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial
The Lancet
Marc A Rodger, William M Hague, John Kingdom, Susan R Kahn, Alan Karovitch, Mathew Sermer, Anne Marie Clement, Suzette Coat, Wee Shian Chan, Joanne Said, Evelyne Rey, Sue Robinson, Rshmi Khurana, Christine Demers, Michael J Kovacs, Susan Solymoss, Kim Hinshaw, James Dwyer, Graeme Smith, Sarah McDonald, Jill Newstead-Angel, Anne McLeod, Meena Khandelwal, Robert M Silver, Gregoire Le Gal, Ian A Greer, Erin Keely, Karen Rosene-Montella, Mark Walker, Philip S Wells
DOI: 10.1016/s0140-6736(14)60793-5
11/2014

When should we use diagnostic imaging to investigate for pulmonary embolism in pregnant and postpartum women?
Emergency Medicine Journal
Steve Goodacre, Catherine Nelson-Piercy, Beverley Hunt, Wee-Shian Chan
DOI: 10.1136/emermed-2014-203871
07/2014

Venous Thromboembolism and Antithrombotic Therapy in Pregnancy
Journal of Obstetrics and Gynaecology Canada
Wee-Shian Chan, Evelyne Rey, Nancy E. Kent, Wee-Shian Chan, Nancy E. Kent, Evelyne Rey, Thomas Corbett, Michèle David, M. Joanne Douglas, Paul S. Gibson, Laura Magee, Marc Rodger, Reginald E. Smith
DOI: 10.1016/s1701-2163(15)30569-7
06/2014

Multidisciplinary meeting of minds
Obstetric Medicine
Wee-Shian Chan and Jayson Potts and Lucille Wilkinson
DOI: 10.1177/1753495x14534572
05/2014

Focused 2012 Update of the Canadian Cardiovascular Society Guidelines for the Use of Antiplatelet Therapy
Canadian Journal of Cardiology
Jean-François Tanguay, Alan D. Bell, Margaret L. Ackman, Robert D.C. Bauer, Raymond Cartier, Wee-Shian Chan, James Douketis, André Roussin, Gregory Schnell, Subodh Verma, Graham Wong, Shamir R. Mehta
DOI: 10.1016/j.cjca.2013.07.001
11/2013

Safety of withholding anticoagulation in pregnant women with suspected deep vein thrombosis following negative serial compression ultrasound and iliac vein imaging
Canadian Medical Association Journal
W.-S. Chan, F. A. Spencer, A. Y. Y. Lee, S. Chunilal, J. D. Douketis, M. Rodger, J. S. Ginsberg
DOI: 10.1503/cmaj.120895
01/2013

The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines
Canadian Journal of Cardiology
Alan D. Bell, André Roussin, Raymond Cartier, Wee Shian Chan, James D. Douketis, Anil Gupta, Maria E. Kraw, Thomas F. Lindsay, Michael P. Love, Neesh Pannu, Rémi Rabasa-Lhoret, Ashfaq Shuaib, Philip Teal, Pierre Théroux, Alexander G.G. Turpie, Robert C. Welsh, Jean-François Tanguay
DOI: 10.1016/j.cjca.2010.12.015
05/2011

Critical Illness in Obstetric Patients: Venous Thromboembolism in Pregnancy
Current Women's Health Reviews
Sanjeev Daya Chunilal, Wee Shian Chan
DOI: 10.2174/157340411795445749
05/2011

The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines Executive Summary
Canadian Journal of Cardiology
Alan D. Bell, André Roussin, Raymond Cartier, Wee Shian Chan, James D. Douketis, Anil Gupta, Maria E. Kraw, Thomas F. Lindsay, Michael P. Love, Neesh Pannu, Rémi Rabasa-Lhoret, Ashfaq Shuaib, Philip Teal, Pierre Théroux, A. Graham Turpie, Robert C. Welsh, Jean-François Tanguay
DOI: 10.1016/j.cjca.2010.12.033
03/2011

Maternal mortality and severe maternal morbidity surveillance in Canada
Journal of Obstetrics and Gynaecology Canada
PubMed: 21176325
12/2010

Anatomic Distribution of Deep Vein Thrombosis in Pregnancy
Obstetrical & Gynecological Survey
Wee-Shian Chan, Frederick A. Spencer, Jeffrey S. Ginsberg
DOI: 10.1097/ogx.0b013e3182021d71
09/2010

Neurocognitive Development of Children Following In-Utero Exposure to Labetalol for Maternal Hypertension: A Cohort Study Using a Prospectively Collected Database
Hypertension in Pregnancy
Wee Shian Chan, Gideon Koren, Maru Barrera, Massoud Rezvani, Dafna Knittel-Keren, Irena Nulman
DOI: 10.3109/10641950902777705
07/2010

Prediction Rules Must Be Developed According to Methodological Guidelines
Annals of Internal Medicine
Wee-Shian Chan
DOI: 10.7326/0003-4819-152-4-201002160-00015
02/2010

D-dimer testing in pregnant patients: towards determining the next “level” in the diagnosis of DVT
Journal of Thrombosis and Haemostasis
W.-S. Chan, A. Lee, F. A. Spencer, S. Chunilal, M. Crowther, W. Wu, M. Johnston, M. Rodger, J. S. Ginsberg
DOI: 10.1111/j.1538-7836.2010.03783.x
01/2010

Venous thromboembolism in pregnancy
Expert Review of Cardiovascular Therapy
Wee Shian Chan
DOI: 10.1586/erc.10.169
2010

The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology
Current Opinion in Obstetrics and Gynecology
Wee Shian Chan
DOI: 10.1097/gco.0b013e328329c2b8
06/2009

Management of Venous Thromboembolism in Pregnancy
Deep Vein Thrombosis and Pulmonary Embolism
Wee Shian Chan and Jeffrey S. Ginsberg
DOI: 10.1002/9780470745007.ch16
04/2009

Management of Venous Thromboembolism in Pregnancy
Evidence-Based Hematology
Wee-Shian Chan
DOI: 10.1002/9781444300857.ch13
02/2009

Predicting Deep Venous Thrombosis in Pregnancy: Out in “LEFt” Field?
Obstetrical & Gynecological Survey
Wee-Shian Chan, Agnes Lee, Frederick A. Spencer, Mark Crowther, Marc Rodger, Tim Ramsay, Jeffrey S. Ginsberg
DOI: 10.1097/01.ogx.0000363248.09415.51
2009

Diagnosis of venous thromboembolism in pregnancy: a study in extrapolation or a science in evolution?
Expert Review of Cardiovascular Therapy
Wee-Shian Chan, Jeffrey S Ginsberg
DOI: 10.1586/erc.09.136
2009

Intrahepatic Cholestasis of Pregnancy in Women With a Multiple Pregnancy: An Analysis of Risks and Pregnancy Outcomes
Journal of Obstetrics and Gynaecology Canada
Andrea Y. Lausman, Enas Al-Yaseen, David Sam, Romy Nitsch, Jon F.R. Barrett, Wee-Shian Chan
DOI: 10.1016/s1701-2163(16)32995-4
11/2008

Recurrent venous thromboembolism after pregnancy-associated versus unprovoked thromboembolism
Thrombosis and Haemostasis
Richard H. White, Wee-Shian Chan, Hong Zhou, Jeffrey S. Ginsberg
DOI: 10.1160/th08-04-0238
07/2008

d-Dimer Testing in Pregnancy: Clinically Useful, but at What Cost?
Annals of Internal Medicine
Wee-Shian Chan
DOI: 10.7326/0003-4819-148-6-200803180-00021
03/2008

Author's response: Monitoring Anti-Xa to prevent thrombosis progression in pregnant women treated with low-molecular weight heparin
Thrombosis Research
Wee-Shian Chan
DOI: 10.1016/j.thromres.2007.11.001
01/2008

The “ART” of thromboembolism: A review of assisted reproductive technology and thromboembolic complications
Thrombosis Research
W.S. Chan, M.E. Dixon
DOI: 10.1016/j.thromres.2007.05.023
01/2008

A Red Blood Cell Agglutination d-Dimer Test to Exclude Deep Venous Thrombosis in Pregnancy
Annals of Internal Medicine
Wee-Shian Chan, Sanjeev Chunilal, Agnes Lee, Mark Crowther, Marc Rodger, Jeffrey S. Ginsberg
DOI: 10.7326/0003-4819-147-3-200708070-00005
08/2007

A review of upper extremity deep vein thrombosis in pregnancy: unmasking the 'ART' behind the clot
Journal of Thrombosis and Haemostasis
W.-S. CHAN, J. S. GINSBERG
DOI: 10.1111/j.1538-7836.2006.02026.x
08/2006

Treatment of venous thromboembolism in pregnancy
Current Treatment Options in Cardiovascular Medicine
Wee Shian Chan
DOI: 10.1007/s11936-004-0043-2
04/2004

Risk of Stroke in Women Exposed to Low-Dose Oral ContraceptivesA Critical Evaluation of the Evidence
Archives of Internal Medicine
Wee-Shian Chan, Joel Ray, Eugene K. Wai, Shiphira Ginsburg, Mary E. Hannah, Paul N. Corey, Jeffrey S. Ginsberg
DOI: 10.1001/archinte.164.7.741
04/2004

Maternal Body Mass Index and the Risk of Preeclampsia: A Systematic Overview
Epidemiology
Tara E. O’Brien, Joel G. Ray, Wee-Shian Chan
DOI: 10.1097/01.ede.0000059921.71494.d1
05/2003

Diagnosis of deep vein thrombosis and pulmonary embolism in pregnancy
Thrombosis Research
Wee-Shian Chan, Jeffrey S Ginsberg
DOI: 10.1016/s0049-3848(02)00105-6
08/2002

Suspected Pulmonary Embolism in PregnancyClinical Presentation, Results of Lung Scanning, and Subsequent Maternal and Pediatric Outcomes
Archives of Internal Medicine
W. S. Chan, J. G. Ray, S. Murray, G. E. Coady, G. Coates, J. S. Ginsberg
DOI: 10.1001/archinte.162.10.1170
05/2002

Preconception Care and the Risk of Congenital Anomalies in the Offspring of Women With Diabetes Mellitus: A Meta-Analysis
Obstetrical and Gynecological Survey
J. G. Ray, T. E. O’Brien, W. S. Chan
DOI: 10.1097/00006254-200202000-00006
02/2002

Antithrombotic therapy during pregnancy
Seminars in Perinatology
Wee S. Chan, Sanjeev D. Chunilal, Jeffrey S. Ginsberg
DOI: 10.1053/sper.2001.24899
06/2001

Anticoagulation of Pregnant Women With Mechanical Heart ValvesA Systematic Review of the Literature
Archives of Internal Medicine
Wee Shian Chan, Sonia Anand, Jeffrey S. Ginsberg
DOI: 10.1001/archinte.160.2.191
01/2000

Low Molecular Weight Heparin Use During Pregnancy: Issues of Safety and Practicality
Obstetrical & Gynecological Survey
Wee Shian Chan, Joel G. Ray
DOI: 10.1097/00006254-199910000-00022
10/1999

What Is the Optimal Management of Pregnant Women with Valvular Heart Disease in Pregnancy?
Pathophysiology of Haemostasis and Thrombosis
Wee Shian Chan
DOI: 10.1159/000054124
1999

Research
Grants

Canadian Institutes of Health Research Operating Grant Competition - Project: "A Pilot Study Assessing Feasibility of a Randomized, Placebo-controlled Trial of Low Molecular Weight-Heparin for Postpartum Prophylaxis in Women at Risk of Developing Venous Thromboembolism." Co-investigator. Total Funding: $450,000 (2010 - 2012)

Canadian Institutes of Health Research Control of Hypertension in Pregnancy Study. Co-investigator. (2009 - 2013)

National Institute of Health grant - Project: "Exploring Host Gene Expression during Post-Exertional Symptom Flare in ME/CFS: An experimental approach." Co-investigator. Total Funding: $271,828 (2015 - 2017)

Honours & Awards

2002/7 - 2003/1 Marion Hillard Award-School Fees, Women's College Hospital

2008/7 - 2009/6 Undergraduate Education Award, General Internal Medicine, Dept of Medicine, Faculty of Medicine Women's College Hospital. Description: In recognition of excellence in teaching, educational leadership and education administration at the undergraduate level.

2004/9 - Young Investigator's Award - Distinction, Sunnybrook and Women's Health Sciences Centre