BCCHR Researchers Find a Researcher

Wee-Shian Chan

MSc, MD, FRCPC, FACP

Investigator, BC Children's Hospital
Head, Department of Medicine, BC Women's Hospital
Lead, Obstetric Medicine, BC Women's Hospital

I work with patients with medical complications in pregnancy, but specifically in the area of Venous Thromboembolism in Pregnancy.

Academic Affiliations

Clinical Professor, Division of General Internal Medicine, Department of Medicine, Faculty of Medicine, University of British Columbia
Research Theme: Healthy Starts

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

(604) 875-3539

weeshian.chan@cw.bc.ca

BC Women's Hospital & Health Centre

Maternal Mortality in the United States: The Need for Accurate Surveillance

Paediatric and Perinatal Epidemiology

Joseph, K.S. and Lisonkova, S. and Boutin, A. and Muraca, G.M. and Razaz, N. and John, S. and Sabr, Y. and Chan, W.-S. and Mehrabadi, A. and Brandt, J.S.

DOI: 10.1111/ppe.13168

Patient and healthcare providers perspectives on participation in a postpartum pilot trial of venous thromboembolism prophylaxis: a qualitative study

Journal of Thrombosis and Haemostasis

Andrew, L. and Garven, A. and Taylor, T.S. and Bates, S.M. and Duffett, L. and Dubois, S. and Malinowski, A.K. and El-Cha{\^a}r, D. and Chan, W.-S. and Donnelly, J. and Chauleur, C. and Ganzevoort, W. and McCarthy, C. and Wiegers, H. and N{\'i} ?inle, F. and Buchmuller, A. and Gibson, P.S. and Middeldorp, S. and Rodger, M.A. and Skeith, L.

DOI: 10.1016/j.jtha.2025.02.039

Neuraxial procedures and time to recognition of postpartum lower limb sensorimotor deficit in an obstetric cohort: a retrospective cohort study (2013"2022)

International Journal of Obstetric Anesthesia

Yang, T. and Chan, W.-S. and Chau, A.

DOI: 10.1016/j.ijoa.2025.104740

Health outcomes of patients in the Complex Chronic Diseases Program

British Columbia Medical Journal

Meagher, E. and Magel, T. and Boulter, T. and Mu{\~n}oz, C. and Prestley, N. and Chan, W.-S. and Bryden, C. and Nacul, L.

Low-dose aspirin versus placebo in postpartum venous thromboembolism: a multi-national, pilot, randomised, placebo-controlled trial

Lancet Haematology

Skeith, L. and Malinowski, A.K. and El-Cha{\^a}r, D. and Chan, W.-S. and Donnelly, J. and Chauleur, C. and Ganzevoort, W. and Wood, S. and Dubois, S. and McCarthy, C. and Buchmuller, A. and Wiegers, H. and Gibson, P.S. and N{\'i} ?inle, F. and Middeldorp, S. and Duffett, L. and Bates, S.M. and Garven, A. and Baxter, J. and Lethebe, B.C. and Rodger, M.A.

DOI: 10.1016/S2352-3026(24)00338-7

Implementation of a home blood pressure monitoring program for the management of hypertensive disorders of pregnancy, an observational study in British Columbia, Canada

Obstetric Medicine

Tran, K.C. and Freiman, S. and Chaworth-Musters, T. and Purkiss, S. and Foster, C. and Khan, N.A. and Chan, W.S.

DOI: 10.1177/1753495X231172050

Maternal Mortality in the United States: Are the High and Rising Rates Due to Changes in Obstetrical Factors, Maternal Medical Conditions, or Maternal Mortality Surveillance?

Obstetrical and Gynecological Survey

Joseph, K.S. and Lisonkova, S. and Boutin, A. and Muraca, G.M. and Razaz, N. and John, S. and Sabr, Y. and Chan, W.-S. and Mehrabadi, A. and Brandt, J.S. and Schisterman, E.F. and Ananth, C.V.

DOI: 10.1097/01.ogx.0001083424.81017.ba

Spatiotemporal patterns and surveillance artifacts in maternal mortality in the United States: a population-based study

Lancet Regional Health Americas

Joseph, K.S. and Lisonkova, S. and Boutin, A. and Muraca, G.M. and Razaz, N. and John, S. and Sabr, Y. and Simon, S. and K{\"o}gl, J. and Suarez, E.A. and Chan, W.-S. and Mehrabadi, A. and Brandt, J.S. and Schisterman, E.F. and Ananth, C.V.

DOI: 10.1016/j.lana.2024.100902

Complex Chronic Diseases Program: Program Description & Health Outcomes Assessment from a Clinical Data Registry

Medrxiv

Meagher, E. and Magel, T. and Boulter, T. and Muoz, C. and Prestley, N. and Chan, W.-S. and Bryden, C. and Nacul, L.

DOI: 10.1101/2024.05.25.24307912

Temporal changes in maternal mortality in the United States

American Journal of Obstetrics and Gynecology

Joseph, K.S. and Lisonkova, S. and John, S. and Sabr, Y. and Boutin, A. and Muraca, G.M. and Razaz, N. and Chan, W.-S. and Mehrabadi, A. and Brandt, J.S. and Schisterman, E.F. and Ananth, C.V.

DOI: 10.1016/j.ajog.2024.04.056

Post-partum maternal bradycardia: A case series and literature review

Obstetric Medicine

Tran, K.C. and Fayowski, C.D. and Chaworth-Musters, T. and Purkiss, S.E. and Chau, A. and Bennett, M.T. and Chan, W.S.

DOI: 10.1177/1753495X231178407

A comparison of perinatal outcomes associated with gestational diabetes mellitus testing practices in British Columbia: A population-based retrospective cohort study

Canadian Journal of Public Health

Luke, S. and Bohn, M.K. and Boutin, A. and Giesbrecht, E. and Vallance, H. and Chan, W.-S. and Barakauskas, V.

DOI: 10.17269/s41997-024-00977-4

Why improved surveillance is critical for reducing maternal deaths in the United States: a response to the American College of Obstetricians and Gynecologists

American Journal of Obstetrics and Gynecology

Joseph, K.S. and Lisonkova, S. and Boutin, A. and Muraca, G.M. and Razaz, N. and John, S. and Sabr, Y. and Chan, W.-S. and Mehrabadi, A. and Brandt, J.S. and Schisterman, E.F. and Ananth, C.V.

DOI: 10.1016/j.ajog.2024.05.003

Temporal changes in pre-existing health conditions five years prior to pregnancy in British Columbia, Canada, 2000"2019

Paediatric and Perinatal Epidemiology

Lundborg, L. and Joseph, K.S. and Lisonkova, S. and Chan, W.-S. and Wen, Q. and Ananth, C.V. and Razaz, N.

DOI: 10.1111/ppe.13060

Mining the Gap: Deriving Pregnancy Reference Intervals for Hematology Parameters Using Clinical Datasets

Clinical chemistry

Barakauskas, V.E. and Bohn, M.K. and Branch, E. and Boutin, A. and Albert, A. and Luke, S. and Dittrick, M. and Higgins, V. and Adeli, K. and Vallance, H. and Jung, B. and Dooley, K. and Dahlgren-Scott, L. and Chan, W.-S.

DOI: 10.1093/clinchem/hvad167

A systematic review of posterior reversible encephalopathy syndrome in pregnant women with severe preeclampsia and eclampsia

Obstetric Medicine

Tawati, D.A. and Chan, W.-S.

DOI: 10.1177/1753495X221150302

Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress

Research and Practice in Thrombosis and Haemostasis

Ari{\"e}ns, R.A. and Hunt, B.J. and Agbani, E.O. and Ahnstr{\"o}m, J. and Ahrends, R. and Alikhan, R. and Assinger, A. and Bagoly, Z. and Balduini, A. and Barbon, E. and Barrett, C.D. and Batty, P. and Carneiro, J.D.A. and Chan, W. and de Maat, M. and de Wit, K. and Denis, C. and Ellis, M.H. and Eslick, R. and Fu, H. and Hayward, C.P.M. and Ho-Tin-No{\'e}, B. and Klok, F. and Kumar, R. and Leiderman, K. and Litvinov, R.I. and Mackman, N. and McQuilten, Z. and Neal, M.D. and Parker, W.A.E. and Preston, R.J.S. and Rayes, J. and Rezaie, A.R. and Roberts, L.N. and Rocca, B. and Shapiro, S. and Siegal, D.M. and Sousa, L.P. and Suzuki-Inoue, K. and Zafar, T. and Zhou, J.

DOI: 10.1002/rth2.12747

Home blood pressure monitoring in the diagnosis and treatment of hypertension in pregnancy: a systematic review and meta-analysis

CMAJ open

Tran, K. and Padwal, R. and Khan, N. and Wright, M.-D. and Chan, W.S.

DOI: 10.9778/cmajo.20200099

Assessment of Hypertension Using Clinical Electrocardiogram Features: A First-Ever Review.

Frontiers in medicine

Bird K and Chan G and Lu H and Greeff H and Allen J and Abbott D and Menon C and Lovell NH and Howard N and Chan WS and Fletcher RR and Alian A and Ward R and Elgendi M

DOI: 10.3389/fmed.2020.583331 PubMed: 33344473

12 / 2020

Can pregnancy-adapted algorithms avoid diagnostic imaging for pulmonary embolism?

Hematology. American Society of Hematology. Education Program

Chan WS

DOI: 10.1182/hematology.2020000105 PubMed: 33275675

12 / 2020

Cuffless single-site photoplethysmography for blood pressure monitoring

Journal of Clinical Medicine

Hosanee, M. and Chan, G. and Welykholowa, K. and Cooper, R. and Kyriacou, P.A. and Zheng, D. and Allen, J. and Abbott, D. and Menon, C. and Lovell, N.H. and Howard, N. and Chan, W.-S. and Lim, K. and Fletcher, R. and Ward, R. and Elgendi, M.

DOI: 10.3390/jcm9030723

Ability of a single negative ultrasound to rule out deep vein thrombosis in pregnant women: A systematic review and meta-analysis

Journal of Thrombosis and Haemostasis

Al Lawati, K. and Aljazeeri, J. and Bates, S.M. and Chan, W.-S. and De Wit, K.

DOI: 10.1111/jth.14650

Thromboembolic Disease in Pregnancy

Respiratory Disease in Pregnancy

Chan, W.-S.

DOI: 10.1017/9781108163705.010

Multimodal photoplethysmography-based approaches for improved detection of hypertension

Journal of Clinical Medicine

Welykholowa, K. and Hosanee, M. and Chan, G. and Cooper, R. and Kyriacou, P.A. and Zheng, D. and Allen, J. and Abbott, D. and Menon, C. and Lovell, N.H. and Howard, N. and Chan, W.-S. and Lim, K. and Fletcher, R. and Ward, R. and Elgendi, M.

DOI: 10.3390/jcm9041203

Out-of-office blood pressure measurement for the diagnosis of hypertension in pregnancy: Survey of Canadian Obstetric Medicine and Maternal Fetal Medicine specialists

Obstetric Medicine

Tran, K.C. and Potts, J. and Robertson, J. and Ly, K. and Dayan, N. and Khan, N.A. and Chan, W.

DOI: 10.1177/1753495X18819338

Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing

PLoS ONE

Bouquet, J. and Li, T. and Gardy, J.L. and Kang, X. and Stevens, S. and Stevens, J. and VanNess, M. and Snell, C. and Potts, J. and Miller, R.R. and Morshed, M. and McCabe, M. and Parker, S. and Uyaguari, M. and Tang, P. and Steiner, T. and Chan, W.-S. and De Souza, A.-M. and Mattman, A. and Patrick, D.M. and Chiu, C.Y.

DOI: 10.1371/journal.pone.0212193

Stroke and Cerebrovascular Disease in Pregnancy: Incidence, Temporal Trends, and Risk Factors

Stroke

Liu, S. and Chan, W.-S. and Ray, J.G. and Kramer, M.S. and Joseph, K.S. and Arbour, L. and Auger, N. and Darling, L. and Evans, J. and Joseph, K.S. and Little, J. and Lee, L. and McDonald, S. and Moore, A. and Murphy, P. and Ray, J.G. and Sauve, R. and Scott, H. and Shah, P. and Van Den Hof, M.

DOI: 10.1161/STROKEAHA.118.023118

Association between gestational weight gain and severe adverse birth outcomes in Washington State, US: A population-based retrospective cohort study, 2004-2013

PLoS Medicine

Vivian Ukah, U. and Bayrampour, H. and Sabr, Y. and Razaz, N. and Chan, W.-S. and Lim, K.I. and Lisonkova, S.

DOI: 10.1371/journal.pmed.1003009

Validation of an automated office blood pressure machine in pregnant women according to the AAMI 2013/ISO protocol

Hypertension

Tran, K. and Potts, J. and Purkiss, S. and Robertson, J. and Khan, N. and Padwal, R. and Chan, W.-S.

DOI: 10.1161/HYPERTENSIONAHA.118.12085

Association between prepregnancy body mass index and severe maternal morbidity

Obstetrical and Gynecological Survey

Lisonkova, S. and Muraca, G.M. and Potts, J. and Liauw, J. and Chan, W.-S. and Skoll, A. and Lim, K.I.

DOI: 10.1097/01.ogx.0000532197.91246.54

Canadian stroke best practice consensus statement: Secondary stroke prevention during pregnancy

International Journal of Stroke

Swartz, R.H. and Ladhani, N.N.N. and Foley, N. and Nerenberg, K. and Bal, S. and Barrett, J. and Bushnell, C. and Chan, W.-S. and Chari, R. and Dowlatshahi, D. and Amrani, M.E. and Gandhi, S. and Gubitz, G. and Hill, M.D. and James, A. and Jeerakathil, T. and Jin, A. and Kirton, A. and Lanthier, S. and Lausman, A. and Leffert, L.R. and Mandzia, J. and Menon, B. and Pikula, A. and Poppe, A. and Potts, J. and Ray, J. and Saposnik, G. and Sharma, M. and Smith, E.E. and Bhogal, S. and Smitko, E. and Lindsay, M.P.

DOI: 10.1177/1747493017743801

Diagnosis of venous thromboembolism in pregnancy

Thrombosis Research

Chan, W.-S.

DOI: 10.1016/j.thromres.2017.09.003

Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy

International Journal of Stroke

Ladhani, N.N.N. and Swartz, R.H. and Foley, N. and Nerenberg, K. and Smith, E.E. and Gubitz, G. and Dowlatshahi, D. and Potts, J. and Ray, J.G. and Barrett, J. and Bushnell, C. and Bal, S. and Chan, W.-S. and Chari, R. and El Amrani, M. and Gandhi, S. and Hill, M.D. and James, A. and Jeerakathil, T. and Jin, A. and Kirton, A. and Lanthier, S. and Lausman, A. and Leffert, L.R. and Mandzia, J. and Menon, B. and Pikula, A. and Poppe, A. and Saposnik, G. and Sharma, M. and Bhogal, S. and Smitko, E. and Lindsay, M.P.

DOI: 10.1177/1747493018786617

Association Between Prepregnancy Body Mass Index and Severe Maternal Morbidity.

JAMA

DOI: 10.1097/01.aoa.0000542350.56459.ef PubMed: 29136442

11 / 2017

Maternal age and severe maternal morbidity: A population-based retrospective cohort study

PLoS Medicine

Lisonkova, S. and Potts, J. and Muraca, G.M. and Razaz, N. and Sabr, Y. and Chan, W.-S. and Kramer, M.S.

DOI: 10.1371/journal.pmed.1002307

Low-molecular-weight heparin to prevent postpartum venous thromboembolism. A pilot randomised placebo-controlled trial

Thrombosis and Haematosis

Rodger MA, Phillips P, Kahn SR, James AH, Konkle BA; PROSPER Investigators, Chan, WS, Collaborator, Low-molecular-weight heparin to prevent postpartum venous thromboembolism. A pilot randomised placebo-controlled trial., Thromb Haemost PubMedID: 25373438

PubMed: 25373438

01 / 2015

When should we use diagnostic imaging to investigate for pulmonary embolism in pregnant and postpartum women?

Emergency Medicine Journal

Goodacre, S. and Nelson-Piercy, C. and Hunt, B. and Chan, W.-S.

DOI: 10.1136/emermed-2014-203871

Multidisciplinary meeting of minds

Obstetric Medicine

Chan, W.-S. and Potts, J. and Wilkinson, L.

DOI: 10.1177/1753495X14534572

Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): A multinational open-label randomised trial

The Lancet

Rodger, M.A. and Hague, W.M. and Kingdom, J. and Kahn, S.R. and Karovitch, A. and Sermer, M. and Clement, A.M. and Coat, S. and Chan, W.S. and Said, J. and Rey, E. and Robinson, S. and Khurana, R. and Demers, C. and Kovacs, M.J. and Solymoss, S. and Hinshaw, K. and Dwyer, J. and Smith, G. and McDonald, S. and Newstead-Angel, J. and McLeod, A. and Khandelwal, M. and Silver, R.M. and Le Gal, G. and Greer, I.A. and Keely, E. and Rosene-Montella, K. and Walker, M. and Wells, P.S.

DOI: 10.1016/S0140-6736(14)60793-5

Venous Thromboembolism and Antithrombotic Therapy in Pregnancy

Journal of Obstetrics and Gynaecology Canada

Chan, W.-S. and Rey, E. and Kent, N.E. and Corbett, T. and David, M. and Douglas, M.J. and Gibson, P.S. and Magee, L. and Rodger, M. and Smith, R.E.

DOI: 10.1016/S1701-2163(15)30569-7

Venous thromboembolism and antithrombotic therapy in pregnancy,Thromboembolie veineuse et traitement antithrombotique pendant la grossesse

Journal of Obstetrics and Gynaecology Canada

Chan, W.-S. and Rey, E. and Kent, N.E. and Corbett, T. and David, M. and Douglas, M.J. and Gibson, P.S. and Magee, L. and Rodger, M. and Smith, R.E.

DOI: 10.1016/S1701-2163(15)30570-3

Safety of withholding anticoagulation in pregnant women with suspected deep vein thrombosis following negative serial compression ultrasound and iliac vein imaging

CMAJ

Chan, W.-S. and Spencer, F.A. and Lee, A.Y.Y. and Chunilal, S. and Douketis, J.D. and Rodger, M. and Ginsberg, J.S.

DOI: 10.1503/cmaj.120895

Focused 2012 update of the Canadian cardiovascular society guidelines for the use of antiplatelet therapy

Canadian Journal of Cardiology

Tanguay, J.-F. and Bell, A.D. and Ackman, M.L. and Bauer, R.D.C. and Cartier, R. and Chan, W.-S. and Douketis, J. and Roussin, A. and Schnell, G. and Verma, S. and Wong, G. and Mehta, S.R.

DOI: 10.1016/j.cjca.2013.07.001

The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines Executive Summary

Canadian Journal of Cardiology

Bell, A.D. and Roussin, A. and Cartier, R. and Chan, W.S. and Douketis, J.D. and Gupta, A. and Kraw, M.E. and Lindsay, T.F. and Love, M.P. and Pannu, N. and Rabasa-Lhoret, R. and Shuaib, A. and Teal, P. and Throux, P. and Turpie, A.G. and Welsh, R.C. and Tanguay, J.-F.

DOI: 10.1016/j.cjca.2010.12.033

The use of antiplatelet therapy in the outpatient setting: Canadian cardiovascular society guidelines

Canadian Journal of Cardiology

DOI: 10.1016/j.cjca.2010.12.015

Critical illness in obstetric patients: Venous thromboembolism in pregnancy

Current Women's Health Reviews

Chunilal, S.D. and Chan, W.S.

DOI: 10.2174/157340411795445749

Prediction Rules Must Be Developed According to Methodological Guidelines

Annals of Internal Medicine

Wee-Shian Chan

DOI: 10.7326/0003-4819-152-4-201002160-00015

02 / 2010

Anatomic distribution of deep vein thrombosis in pregnancy

CMAJ

Chan, W.-S. and Spencer, F.A. and Ginsberg, J.S.

DOI: 10.1503/cmaj.091692

Maternal Mortality and Severe Maternal Morbidity Surveillance in Canada

Journal of Obstetrics and Gynaecology Canada

Allen, V.M. and Campbell, M. and Carson, G. and Fraser, W. and Liston, R.M. and Walker, M. and Barrett, J. and Anthony Armson, B. and Bartholomew, S. and Baskett, T.F. and Blake, J. and Bocking, A. and Cecatti, J.G. and Chan, W.S. and Coetzee, J. and Gysler, M. and Katherine, W. and Keith, L. and Moskal, L. and Say, L. and Senikas, V. and Sermer, M. and Wen, S.W. and Wood, P.

DOI: 10.1016/S1701-2163(16)34737-5

D-dimer testing in pregnant patients: Towards determining the next 'level' in the diagnosis of deep vein thrombosis

Journal of Thrombosis and Haemostasis

Chan, W.-S. and Lee, A. and Spencer, F.A. and Chunilal, S. and Crowther, M. and Wu, W. and Johnston, M. and Rodger, M. and Ginsberg, J.S.

DOI: 10.1111/j.1538-7836.2010.03783.x

Neurocognitive development of children following in-utero exposure to labetalol for maternal hypertension: A cohort study using a prospectively collected database

Hypertension in Pregnancy

Chan, W.S. and Koren, G. and Barrera, M. and Rezvani, M. and Knittel-Keren, D. and Nulman, I.

DOI: 10.3109/10641950902777705

Approach to Prosthetic Heart Valves in Pregnancy

de Swiet's Medical Disorders in Obstetric Practice: Fifth Edition

Chan, W.S. and Walker, M.C. and Rodger, M.A.

DOI: 10.1002/9781444323016.ch46

Venous thromboembolism in pregnancy

Expert Review of Cardiovascular Therapy

Chan, W.S.

DOI: 10.1586/erc.10.169

Predicting deep venous thrombosis in pregnancy: Out in "LEFt" field?

Annals of Internal Medicine

Chan, W.-S. and Lee, A. and Spencer, F.A. and Crowther, M. and Rodger, M. and Ramsay, T. and Ginsberg, J.S.

DOI: 10.7326/0003-4819-151-2-200907210-00004

The 'ART' of thrombosis: A review of arterial and venous thrombosis in assisted reproductive technology

Current Opinion in Obstetrics and Gynecology

Chan, W.S.

DOI: 10.1097/GCO.0b013e328329c2b8

Diagnosis of venous thromboembolism in pregnancy: A study in extrapolation or a science in evolution?

Expert Review of Cardiovascular Therapy

Chan, W.-S. and Ginsberg, J.S.

DOI: 10.1586/erc.09.136

Predicting deep venous thrombosis in pregnancy: Out in "LEFt" field? (Annals of Internal Medicine (2009) 151, (85-92))

Annals of Internal Medicine

Chan, W.S. and Lee, A. and Spencer, F.A. and Crowther, M. and Rodger, M. and Ramsay, T.

Management of Venous Thromboembolism in Pregnancy

Deep Vein Thrombosis and Pulmonary Embolism

Chan, W.S. and Ginsberg, J.S.

DOI: 10.1002/9780470745007.ch16

d-Dimer Testing in Pregnancy: Clinically Useful, but at What Cost?

Annals of Internal Medicine

Wee-Shian Chan

DOI: 10.7326/0003-4819-148-6-200803180-00021

03 / 2008

Intrahepatic Cholestasis of Pregnancy in Women With a Multiple Pregnancy: An Analysis of Risks and Pregnancy Outcomes

Journal of Obstetrics and Gynaecology Canada

Lausman, A.Y. and Al-Yaseen, E. and Sam, D. and Nitsch, R. and Barrett, J.F.R. and Chan, W.-S.

DOI: 10.1016/S1701-2163(16)32995-4

Recurrent venous thromboembolism after pregnancy-associated versus unprovoked thromboembolism

Thrombosis and Haemostasis

White, R.H. and Chan, W.-S. and Zhou, H. and Ginsberg, J.S.

DOI: 10.1160/TH08-04-0238

In response

Annals of Internal Medicine

Chan, W.-S. and Ginsberg, J.S.

Author's response: Monitoring Anti-Xa to prevent thrombosis progression in pregnant women treated with low-molecular weight heparin

Thrombosis Research

Chan, W.-S.

DOI: 10.1016/j.thromres.2007.11.001

The "ART" of thromboembolism: A review of assisted reproductive technology and thromboembolic complications

Thrombosis Research

Chan, W.S. and Dixon, M.E.

DOI: 10.1016/j.thromres.2007.05.023

A red blood cell agglutination D-dimer test to exclude deep venous thrombosis in pregnancy

Annals of Internal Medicine

Chan, W.-S. and Chunilal, S. and Lee, A. and Crowther, M. and Rodger, M. and Ginsberg, J.S.

DOI: 10.7326/0003-4819-147-3-200708070-00005

A review of upper extremity deep vein thrombosis in pregnancy: Unmasking the 'ART' behind the clot

Journal of Thrombosis and Haemostasis

Chan, W.-S. and Ginsberg, J.S.

DOI: 10.1111/j.1538-7836.2006.02026.x

Treatment of venous thromboembolism in pregnancy

Current Treatment Options in Cardiovascular Medicine

Chan, W.S.

DOI: 10.1007/s11936-004-0043-2

Risk of Stroke in Women Exposed to Low-Dose Oral Contraceptives: A Critical Evaluation of the Evidence

Archives of Internal Medicine

Chan, W.-S. and Ray, J. and Wai, E.K. and Ginsburg, S. and Hannah, M.E. and Corey, P.N. and Ginsberg, J.S.

DOI: 10.1001/archinte.164.7.741

Anticoagulation of pregnant women with mechanical heart valves

Archives of Internal Medicine

Ginsberg, J.S. and Chan, W.S. and Bates, S.M. and Kaatz, S.

DOI: 10.1001/archinte.163.6.694

Maternal body mass index and the risk of preeclampsia: A systematic overview

Epidemiology

O'Brien, T.E. and Ray, J.G. and Chan, W.-S.

DOI: 10.1097/00001648-200305000-00020

Longterm anticoagulation is preferable for patients with antiphospholipid antibody syndrome. Result of a decision analysis

Journal of Rheumatology

Brunner, H.I. and Chan, W.-S. and Ginsberg, J.S. and Feldman, B.M.

Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: Meta-analysis of 31 studies

Pathophysiology of Haemostasis and Thrombosis

Ray, J.G. and Shmorgun, D. and Chan, W.S.

DOI: 10.1159/000065076

Association between Bell's palsy in pregnancy and pre-eclampsia

QJM - Monthly Journal of the Association of Physicians

Shmorgun, D. and Chan, W.-S. and Ray, J.G.

DOI: 10.1093/qjmed/95.6.359

Suspected pulmonary embolism in pregnancy: Clinical presentation, results of lung scanning, and subsequent maternal and pediatric outcomes

Archives of Internal Medicine

Chan, W.S. and Ray, J.G. and Murray, S. and Coady, G.E. and Coates, G. and Ginsberg, J.S.

DOI: 10.1001/archinte.162.10.1170

Venous thromboembolism in gynecology

Contemporary Clinical Gynecology and Obstetrics

Chan, W.-S. and Ginsberg, J.S.

Diagnosis of deep vein thrombosis and pulmonary embolism in pregnancy

Thrombosis Research

Chan, W.-S. and Ginsberg, J.S.

DOI: 10.1016/S0049-3848(02)00105-6

Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: A meta-analysis

QJM - Monthly Journal of the Association of Physicians

Ray, J.G. and O'brien, T.E. and Chan, W.S.

DOI: 10.1093/qjmed/94.8.435

Antithrombotic therapy during pregnancy

Seminars in Perinatology

Chan, W.S. and Chunilal, S.D. and Ginsberg, J.S.

DOI: 10.1053/sper.2001.24899

Anticoagulation of pregnant women with mechanical heart valves: A systematic review of the literature

Archives of Internal Medicine

Chan, W.S. and Anand, S. and Ginsberg, J.S.

DOI: 10.1001/archinte.160.2.191

Low molecular weight heparin use during pregnancy: Issues of safety and practicality

Obstetrical and Gynecological Survey

Chan, W.S. and Ray, J.G.

DOI: 10.1097/00006254-199910000-00022

What is the optimal management of pregnant women with valvular heart disease in pregnancy?

Haemostasis

Chan, W.S.

DOI: 10.1159/000054124

Deep vein thrombosis during pregnancy and the puerperium: A meta- analysis of the period of risk and the leg of presentation

Obstetrical and Gynecological Survey

Ray, J.G. and Chan, W.S.

DOI: 10.1097/00006254-199904000-00023

Pregnancy in chronic dialysis: A review and analysis of the literature

International Journal of Artificial Organs

Chan, W.S. and Okun, N. and Kjellstrand, C.M.

DOI: 10.1177/039139889802100503

Safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast

Mutation Research/Genetic Toxicology

Schiestl, R.H. and Chan, W.S. and Daniel Gietz, R. and Mehta, R.D. and Hastings, P.J.

DOI: 10.1016/0165-1218(89)90067-0

Grants

Canadian Institutes of Health Research Operating Grant Competition - Project

"A Pilot Study Assessing Feasibility of a Randomized, Placebo-controlled Trial of Low Molecular Weight-Heparin for Postpartum Prophylaxis in Women at Risk of Developing Venous Thromboembolism." Co-investigator. Total Funding

$450,000 (2010 - 2012)

National Institute of Health grant - Project

"Exploring Host Gene Expression during Post-Exertional Symptom Flare in ME/CFS

An experimental approach." Co-investigator. Total Funding

$271,828 (2015 - 2017)

Canadian Institutes of Health Research Control of Hypertension in Pregnancy Study. Co-investigator. (2009 - 2013)

Honours & Awards

2008/7 - 2009/6 Undergraduate Education Award, General Internal Medicine, Dept of Medicine, Faculty of Medicine Women's College Hospital. Description

In recognition of excellence in teaching, educational leadership and education administration at the undergraduate level.

2002/7 - 2003/1 Marion Hillard Award-School Fees, Women's College Hospital

2004/9 - Young Investigator's Award - Distinction, Sunnybrook and Women's Health Sciences Centre

Related News

Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.

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Congratulations CIHR Grant Recipients!
Congratulations to the BC Children's and BC Women's investigators who were awarded funding through the Canadian Institutes of Health Research (CIHR) Project Grant Fall 2020 competition. Our research community received around $6 million in new research grants.
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Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Wee-Shian Chan

MSc, MD, FRCPC, FACP

Investigator, BC Children's Hospital Head, Department of Medicine, BC Women's Hospital Lead, Obstetric Medicine, BC Women's Hospital

Academic Affiliations

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Maternal Mortality in the United States: The Need for Accurate Surveillance

Patient and healthcare providers perspectives on participation in a postpartum pilot trial of venous thromboembolism prophylaxis: a qualitative study

Neuraxial procedures and time to recognition of postpartum lower limb sensorimotor deficit in an obstetric cohort: a retrospective cohort study (2013"2022)

Health outcomes of patients in the Complex Chronic Diseases Program

Low-dose aspirin versus placebo in postpartum venous thromboembolism: a multi-national, pilot, randomised, placebo-controlled trial

Implementation of a home blood pressure monitoring program for the management of hypertensive disorders of pregnancy, an observational study in British Columbia, Canada

Maternal Mortality in the United States: Are the High and Rising Rates Due to Changes in Obstetrical Factors, Maternal Medical Conditions, or Maternal Mortality Surveillance?

Spatiotemporal patterns and surveillance artifacts in maternal mortality in the United States: a population-based study

Complex Chronic Diseases Program: Program Description & Health Outcomes Assessment from a Clinical Data Registry

Temporal changes in maternal mortality in the United States

Post-partum maternal bradycardia: A case series and literature review

A comparison of perinatal outcomes associated with gestational diabetes mellitus testing practices in British Columbia: A population-based retrospective cohort study

Why improved surveillance is critical for reducing maternal deaths in the United States: a response to the American College of Obstetricians and Gynecologists

Temporal changes in pre-existing health conditions five years prior to pregnancy in British Columbia, Canada, 2000"2019

Mining the Gap: Deriving Pregnancy Reference Intervals for Hematology Parameters Using Clinical Datasets

A systematic review of posterior reversible encephalopathy syndrome in pregnant women with severe preeclampsia and eclampsia

Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress

Home blood pressure monitoring in the diagnosis and treatment of hypertension in pregnancy: a systematic review and meta-analysis

Assessment of Hypertension Using Clinical Electrocardiogram Features: A First-Ever Review.

Can pregnancy-adapted algorithms avoid diagnostic imaging for pulmonary embolism?

Cuffless single-site photoplethysmography for blood pressure monitoring

Ability of a single negative ultrasound to rule out deep vein thrombosis in pregnant women: A systematic review and meta-analysis

Thromboembolic Disease in Pregnancy

Multimodal photoplethysmography-based approaches for improved detection of hypertension

Out-of-office blood pressure measurement for the diagnosis of hypertension in pregnancy: Survey of Canadian Obstetric Medicine and Maternal Fetal Medicine specialists

Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing

Stroke and Cerebrovascular Disease in Pregnancy: Incidence, Temporal Trends, and Risk Factors

Association between gestational weight gain and severe adverse birth outcomes in Washington State, US: A population-based retrospective cohort study, 2004-2013

Validation of an automated office blood pressure machine in pregnant women according to the AAMI 2013/ISO protocol

Association between prepregnancy body mass index and severe maternal morbidity

Canadian stroke best practice consensus statement: Secondary stroke prevention during pregnancy

Diagnosis of venous thromboembolism in pregnancy

Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy

Association Between Prepregnancy Body Mass Index and Severe Maternal Morbidity.

Maternal age and severe maternal morbidity: A population-based retrospective cohort study

Low-molecular-weight heparin to prevent postpartum venous thromboembolism. A pilot randomised placebo-controlled trial

When should we use diagnostic imaging to investigate for pulmonary embolism in pregnant and postpartum women?

Multidisciplinary meeting of minds

Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): A multinational open-label randomised trial

Venous Thromboembolism and Antithrombotic Therapy in Pregnancy

Venous thromboembolism and antithrombotic therapy in pregnancy,Thromboembolie veineuse et traitement antithrombotique pendant la grossesse

Safety of withholding anticoagulation in pregnant women with suspected deep vein thrombosis following negative serial compression ultrasound and iliac vein imaging

Focused 2012 update of the Canadian cardiovascular society guidelines for the use of antiplatelet therapy

The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines Executive Summary

The use of antiplatelet therapy in the outpatient setting: Canadian cardiovascular society guidelines

Critical illness in obstetric patients: Venous thromboembolism in pregnancy

Prediction Rules Must Be Developed According to Methodological Guidelines

Anatomic distribution of deep vein thrombosis in pregnancy

Maternal Mortality and Severe Maternal Morbidity Surveillance in Canada

D-dimer testing in pregnant patients: Towards determining the next 'level' in the diagnosis of deep vein thrombosis

Neurocognitive development of children following in-utero exposure to labetalol for maternal hypertension: A cohort study using a prospectively collected database

Approach to Prosthetic Heart Valves in Pregnancy

Venous thromboembolism in pregnancy

Predicting deep venous thrombosis in pregnancy: Out in "LEFt" field?

The 'ART' of thrombosis: A review of arterial and venous thrombosis in assisted reproductive technology

Diagnosis of venous thromboembolism in pregnancy: A study in extrapolation or a science in evolution?

Predicting deep venous thrombosis in pregnancy: Out in "LEFt" field? (Annals of Internal Medicine (2009) 151, (85-92))

Management of Venous Thromboembolism in Pregnancy

d-Dimer Testing in Pregnancy: Clinically Useful, but at What Cost?

Intrahepatic Cholestasis of Pregnancy in Women With a Multiple Pregnancy: An Analysis of Risks and Pregnancy Outcomes

Recurrent venous thromboembolism after pregnancy-associated versus unprovoked thromboembolism

In response

Author's response: Monitoring Anti-Xa to prevent thrombosis progression in pregnant women treated with low-molecular weight heparin

The "ART" of thromboembolism: A review of assisted reproductive technology and thromboembolic complications

A red blood cell agglutination D-dimer test to exclude deep venous thrombosis in pregnancy

A review of upper extremity deep vein thrombosis in pregnancy: Unmasking the 'ART' behind the clot

Treatment of venous thromboembolism in pregnancy

Risk of Stroke in Women Exposed to Low-Dose Oral Contraceptives: A Critical Evaluation of the Evidence

Anticoagulation of pregnant women with mechanical heart valves

Maternal body mass index and the risk of preeclampsia: A systematic overview

Longterm anticoagulation is preferable for patients with antiphospholipid antibody syndrome. Result of a decision analysis

Investigator, BC Children's Hospital
Head, Department of Medicine, BC Women's Hospital
Lead, Obstetric Medicine, BC Women's Hospital