Overview

Development from conception to birth is the result of a complex interplay of signals from mother and fetus. The placenta plays a key role in interpreting these signals and regulating fetal growth. Many complications of pregnancy, including miscarriage, maternal preeclampsia, preterm birth, fetal growth restriction and birth defects can result from abnormalities affecting the placenta. Some goals of our research include:

Developing a basic understanding of how genetic and epigenetic changes arise in development;

Identifying changes in the placenta in association with pregnancy complication; and

Developing DNA and miRNA based clinical tools

Publications

Exome sequencing identified a de novo mutation of PURA gene in a patient with familial Xp22.31 microduplication
European Journal of Medical Genetics
Ying Qiao, Hani Bagheri, Flamingo Tang, Chansonette Badduke, Sally Martell, Suzanne M.E. Lewis, Wendy Robinson, Mary B. Connolly, Laura Arbour, Evica Rajcan-Separovic
DOI: 10.1016/j.ejmg.2018.06.010
06/2018

Mining DNA methylation alterations towards a classification of placental pathologies
Human Molecular Genetics
Samantha L Wilson, Katherine Leavey, Brian J Cox, Wendy P Robinson
DOI: 10.1093/hmg/ddx391
01/2018

Utility of DNA methylation to assess placental health
Placenta
Wilson, Samantha L. and Robinson, Wendy P.
DOI: 10.1016/j.placenta.2017.12.013
2018

No evidence for association of MTHFR 677C > T and 1298A > C variants with placental DNA methylation
Clinical Epigenetics
Del Gobbo, Giulia F. and Price, E. Magda and Hanna, Courtney W. and Robinson, Wendy P.
DOI: 10.1186/s13148-018-0468-1
2018

Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia
Clinical Epigenetics
Leavey, Katherine and Wilson, Samantha L. and Bainbridge, Shannon A. and Robinson, Wendy P. and Cox, Brian J.
DOI: 10.1186/s13148-018-0463-6
2018

Adjusting for Batch Effects in DNA Methylation Microarray Data, a Lesson Learned
Frontiers in Genetics
Price, E. M. and Robinson, Wendy P.
DOI: 10.3389/fgene.2018.00083
2018

A de novo mosaic mutation in SPAST with two novel alternative alleles and chromosomal copy number variant in a boy with spastic paraplegia and autism spectrum disorder
European Journal of Medical Genetics
Matthews, A. M. and Tarailo-Graovac, M. and Price, E. M. and Blydt-Hansen, I. and Ghani, A. and Drogemoller, B. I. and Robinson, W. P. and Ross, C. J. and Wasserman, W. W. and Siden, H. and van Karnebeek, C. D.
DOI: 10.1016/j.ejmg.2017.07.015
2017

Effect of Maternal Depression and Prenatal Antidepressant Exposure on Placental Serotoninergic and Glucocorticoids Systems Methylation
Birth Defects Research
Laurent, L. and Penaherrera, M. and Robinson, W. P. and Oberlander, T. F. and Vaillancourt, C.
2017

Review: placental biomarkers for assessing fetal health
Human Molecular Genetics
Manokhina, Irina and Del Gobbo, Giulia F. and Konwar, Chaini and Wilson, Samantha L. and Robinson, Wendy P.
DOI: 10.1093/hmg/ddx210
2017

Whole exome sequencing of families with 1q21.1 microdeletion or microduplication
American Journal of Medical Genetics Part a
Qiao, Ying and Badduke, Chansonette and Tang, Flamingo and Cowieson, David and Martell, Sally and Lewis, Suzanne M. E. and Penaherrera, Maria S. and Robinson, Wendy P. and Volchuk, Allen and Rajcan-Separovic, Evica
DOI: 10.1002/ajmg.a.38247
2017

An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs
Clinical Epigenetics
Edgar, Rachel D. and Jones, Meaghan J. and Robinson, Wendy P. and Kobor, Michael S.
DOI: 10.1186/s13148-017-0320-z
2017

Cell-Free Placental DNA in Maternal Plasma in Relation to Placental Health and Function
Fetal Diagnosis and Therapy
Manokhina, Irina and Singh, Tanjot K. and Robinson, Wendy P.
DOI: 10.1159/000448707
2017

Child mortality, hypothalamic-pituitaryadrenal axis activity and cellular aging in mothers
Plos One
Barha, Cindy K. and Salvante, Katrina G. and Hanna, Courtney W. and Wilson, Samantha L. and Robinson, Wendy P. and Altman, Rachel M. and Nepomnaschy, Pablo A.
DOI: 10.1371/journal.pone.0177869
2017

Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns
Clinical Epigenetics
de Goede, Olivia M. and Lavoie, Pascal M. and Robinson, Wendy P.
DOI: 10.1186/s13148-017-0339-1
2017

Placental telomere length decline with gestational age differs by sex and TERT, DNMT1, and DNMT3A DNA methylation
Placenta
Samantha L. Wilson, Yao Liu, Wendy P. Robinson
DOI: 10.1016/j.placenta.2016.10.001
12/2016

Number of Children and Telomere Length in Women: A Prospective, Longitudinal Evaluation
PLoS ONE
Cindy K. Barha, Courtney W. Hanna, Katrina G. Salvante, Samantha L. Wilson, Wendy P. Robinson, Rachel M. Altman, Pablo A. Nepomnaschy
DOI: 10.1371/journal.pone.0146424
01/2016

USING DNA METHYLATION SIGNATURES IN PLACENTAL TISSUE AND CELLS TO GAIN INSIGHT INTO CHORIOAMNIONITIS
Placenta
Konwar, Chaini and Price, E. Magda and Robinson, Wendy P.
DOI: 10.1016/j.placenta.2016.06.180
2016

UNRAVELLING THE RELATIONSHIP BETWEEN EARLY AND LATE-ONSET PREECLAMPSIA. WHAT DOES THE PLACENTAL DNA METHYLATION PROFILE REVEAL?
Placenta
Wilson, Samantha L. and Leavey, Katherine and von Dadelszen, Peter and Cox, Brian and Robinson, Wendy P.
DOI: 10.1016/j.placenta.2016.06.184
2016

TRANSCRIPTOMIC PROFILING OF SNCRNA IN PLACENTA BY RNASEQ
Placenta
Price, E. Magda and Martinez, Victor and Becker-Santos, Daiana and Manokhina, Irina and Lam, Wan L. and Robinson, Wendy P.
2016

Stressful life events, the hypothalamic-pituitary-adrenal axis and cellular aging in women
American Journal of Human Biology
Nepomnaschy, P. A. and Barha, C. K. and Salvante, K. G. and Hanna, C. W. and Wilson, S. L. and Robinson, W. P. and Altman, R. M.
2016

Profiling placental and fetal DNA methylation in human neural tube defects
Epigenetics & Chromatin
Price, E. Magda and Penaherrera, Maria S. and Portales-Casamar, Elodie and Pavlidis, Paul and Van Allen, Margot I. and McFadden, Deborah E. and Robinson, Wendy P.
DOI: 10.1186/s13072-016-0054-8
2016

Pervasive polymorphic imprinted methylation in the human placenta
Genome Research
Hanna, Courtney W. and Penaherrera, Maria S. and Saadeh, Heba and Andrews, Simon and McFadden, Deborah E. and Kelsey, Gavin and Robinson, Wendy P.
DOI: 10.1101/gr.196139.115
2016

Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma
Journal of Pathology
Becker-Santos, Daiana D. and Thu, Kelsie L. and English, John C. and Pikor, Larissa A. and Martinez, Victor D. and Zhang, May and Vucic, Emily A. and Luk, Margaret T. Y. and Carraro, Anita and Korbelik, Jagoda and Piga, Daniela and Lhomme, Nicolas M. and Tsay, Mike J. and Yee, John and MacAulay, Calum E. and Lam, Stephen and Lockwood, William W. and Robinson, Wendy P. and Jurisica, Igor and Lam, Wan L.
DOI: 10.1002/path.4765
2016

Characterizing the hypomethylated DNA methylation profile of nucleated red blood cells from cord blood
Epigenomics
de Goede, Olivia M. and Lavoie, Pascal M. and Robinson, Wendy P.
DOI: 10.2217/epi-2016-0069
2016

Pervasive polymorphic imprinted methylation in the human placenta
Genome research
2016

Profiling placental and fetal DNA methylation in human neural tube defects
Epigenetics & chromatin
2016

Molecular Aspects of Placental Development
Genetic Disorders and the Fetus
Wendy P. Robinson, Deborah E. McFadden
DOI: 10.1002/9781118981559.ch30
11/2015

An integrated transcriptional, epigenetic, and clinical analysis of preeclamptic placentas
Placenta
Katherine Leavey, Samantha Wilson, Shannon Bainbridge, Wendy Robinson, Brian Cox
DOI: 10.1016/j.placenta.2015.07.206
09/2015

Transient and placenta-specific imprinting in human development
Placenta
Courtney Hanna, Maria Penaherrera, Heba Saadeh, Deborah McFadden, Gavin Kelsey, Wendy Robinson
DOI: 10.1016/j.placenta.2015.07.303
09/2015

Biallelic mutations in huntington disease: A new case with just one affected parent, review of the literature and terminology
American Journal of Medical Genetics Part A
2015

The human placental methylome
Cold Spring Harbor perspectives in medicine
Robinson, Wendy P and Price, E Magda
2015

Genome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Molecular human reproduction
Hu, Yuxiang and Blair, John D and Yuen, Ryan KC and Robinson, Wendy P and von Dadelszen, Peter
2015

The genotypic and phenotypic spectrum of PIGA deficiency
Orphanet journal of rare diseases
Tarailo-Graovac, Maja and Sinclair, Graham and Stockler-Ipsiroglu, Sylvia and Van Allen, Margot and Rozmus, Jacob and Shyr, Casper and Biancheri, Roberta and Oh, Tracey and Sayson, Bryan and Lafek, Mirafe and others
2015

IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction
Placenta
Barbaux, S and Erwich, JJHM and Favaron, PO and Gil, S and Gallot, D and Golos, TG and Gonzalez-Bulnes, A and Guibourdenche, J and Heazell, AEP and Jansson, T and others
2015

Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
Orphanet journal of rare diseases
Sirrs, Sandra and van Karnebeek, Clara DM and Peng, Xiaoxue and Shyr, Casper and Tarailo-Graovac, Maja and Mandal, Rupasri and Testa, Daniel and Dubin, Devin and Carbonetti, Gregory and Glynn, Steven E and others
2015

Functional consequences of copy number variants in miscarriage
Mol Cytogenet
Wen, Jiadi and Hanna, Courtney W and Martell, Sally and Leung, Peter CK and Lewis, Suzanne ME and Robinson, Wendy P and Stephenson, Mary D and Rajcan-Separovic, Evica
2015

Defects in fatty acid amid hydrolase 2 associated with developmental and psychiatric disorders
MOLECULAR GENETICS AND METABOLISM
Sirrs, Sandra and Peng, Xiaoxue and Sinclair, Graham and Shyr, Casper and Mandal, Rupasri and Testa, Daniel and Dubin, Devin and Carbonetti, Gregory and Glynn, Steven E and Robinson, Wendy P and others
2015

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion
Cell Death & Differentiation
Aghababaei, M and Hogg, K and Perdu, S and Robinson, WP and Beristain, AG
2015

Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells
Clinical epigenetics
de Goede, Olivia M and Razzaghian, Hamid R and Price, E Magda and Jones, Meaghan J and Kobor, Michael S and Robinson, Wendy P and Lavoie, Pascal M
2015

Noninvasive nucleic acid--based approaches to monitor placental health and predict pregnancy-related complications
American journal of obstetrics and gynecology
Manokhina, Irina and Wilson, Samantha L and Robinson, Wendy P
2015

Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy
BMC medical genetics
Wilson, Samantha L and Blair, John D and Hogg, Kirsten and Langlois, Sylvie and von Dadelszen, Peter and Robinson, Wendy P
2015

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion
Cell Death and Differentiation
Aghababaei, M. and Hogg, K. and Perdu, S. and Robinson, W. P. and Beristain, A. G.
DOI: 10.1038/cdd.2015.44
2015

Quantification of Cell-Free DNA in Normal and Complicated Pregnancies: Overcoming Biological and Technical Issues
PLoS ONE
Irina Manokhina, Tanjot K. Singh, Maria S. Peñaherrera, Wendy P. Robinson
DOI: 10.1371/journal.pone.0101500
07/2014

Improved reporting of DNA methylation data derived from studies of the human placenta
Epigenetics
Kirsten Hogg, E Magda Price, Wendy P Robinson
DOI: 10.4161/epi.27648
01/2014

Quantification of cell-free DNA in normal and complicated pregnancies: overcoming biological and technical issues
PloS one
2014

A cryptic familial rearrangement of 11p15. 5, involving both imprinting centers, in a family with a history of short stature
American Journal of Medical Genetics Part A
2014

IFPA Meeting 2013 Workshop Report II: Use of ‘omics’ in understanding placental development, bioinformatics tools for gene expression analysis, planning and coordination of a placenta research network, placental imaging, evolutionary approaches to understanding pre-eclampsia
Placenta
Ackerman, WE and Adamson, L and Carter, Anthony Michael and Collins, S and Cox, B and Elliot, MG and Ermini, L and Gruslin, A and Hoodless, PA and Huang, J and others
2014

Offspring mortality accelerates the aging process in mothers
AMERICAN JOURNAL OF HUMAN BIOLOGY
Barha, CK and Hanna, CW and Salvante, KG and Robinson, WP and Nepomnaschy, PA
2014

Recurrent triploidy due to a failure to complete maternal Meiosis II: whole exome sequencing reveals candidate variants
Molecular human reproduction
2014

Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes
Human mutation
Qiao, Ying and Mondal, Kajari and Trapani, Valentina and Wen, Jiadi and Carpenter, Gillian and Wildin, Robert and Price, E Magda and Gibbons, Richard J and Eichmeyer, Jennifer and Jiang, Ruby and others
2014

Overlapping DNA methylation profile between placentas with trisomy 16 and early-onset preeclampsia
Placenta
Blair, JD and Langlois, S and McFadden, DE and Robinson, WP
2014

Activation of endocrine-related gene expression in placental choriocarcinoma cell lines following DNA methylation knock-down
Molecular human reproduction
Hogg, K and Robinson, WP and Beristain, AG
2014

Improved reporting of DNA methylation data derived from studies of the human placenta
epigenetics
Hogg, Kirsten and Price, E Magda and Robinson, Wendy P
2014

Global analysis of DNA methylation changes during progression of oral cancer
Oral Oncology
Rebecca Towle, Danielle Truong, Kirsten Hogg, Wendy P. Robinson, Catherine F. Poh, Cathie Garnis
DOI: 10.1016/j.oraloncology.2013.08.005
11/2013

Early Onset Pre-Eclampsia Is Associated with Altered DNA Methylation of Cortisol-Signalling and Steroidogenic Genes in the Placenta
PLoS ONE
Kirsten Hogg, John D. Blair, Deborah E. McFadden, Peter von Dadelszen, Wendy P. Robinson
DOI: 10.1371/journal.pone.0062969
05/2013

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts
Epigenetics
Ryan K.C. Yuen, Baosheng Chen, John D. Blair, Wendy P. Robinson, D. Michael Nelson
DOI: 10.4161/epi.23400
02/2013

X-Chromosome Inactivation
Epigenetics and Complex Traits
Wendy P. Robinson, Allison M. Cotton, Maria S. Peñaherrera, Samantha B. Peeters, Carolyn J. Brown
DOI: 10.1007/978-1-4614-8078-5_3
2013

Glucose as a fetal nutrient: dynamic regulation of several glucose transporter genes by DNA methylation in the human placenta across gestation
The Journal of nutritional biochemistry
Novakovic, Boris and Gordon, Lavinia and Robinson, Wendy P and Desoye, Gernot and Saffery, Richard
2013

miRNA expression in human lung cancer and fetal lung: a comparative study
BMC Proceedings
Becker-Santos, Daiana D and Thu, Kelsie L and Reis, Patricia P and Robinson, Wendy P and Lam, Stephen and Lam, Wan L
2013

X-Chromosome Inactivation
Epigenetics and Complex Traits
2013

Global analysis of DNA methylation changes during progression of oral cancer
Oral oncology
Towle, Rebecca and Truong, Danielle and Hogg, Kirsten and Robinson, Wendy P and Poh, Catherine F and Garnis, Cathie
2013

DNA methylation profiling of placental villi from karyotypically normal miscarriage and recurrent miscarriage
The American journal of pathology
Hanna, Courtney W and McFadden, Deborah E and Robinson, Wendy P
2013

Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta
PloS one
Hogg, Kirsten and Blair, John D and McFadden, Deborah E and von Dadelszen, Peter and Robinson, Wendy P
2013

Beckwith--Wiedemann and Silver--Russell syndromes: opposite developmental imbalances in imprinted regulators of placental function and embryonic growth
Clinical genetics
Jacob, KJ and Robinson, WP and Lefebvre, L
2013

Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset preeclampsia
Molecular human reproduction
Blair, John D and Yuen, Ryan KC and Lim, Brendan K and McFadden, Deborah E and von Dadelszen, Peter and Robinson, Wendy P
2013

Maternal NLRP7 and C6orf221 variants are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage
Molecular human reproduction
Manokhina, I and Hanna, CW and Stephenson, MD and McFadden, DE and Robinson, WP
2013

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts
Epigenetics
Yuen, Ryan KC and Chen, Baosheng and Blair, John D and Robinson, Wendy P and Nelson, D Michael
2013

Hypomethylation of the LEP gene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia
Molecular and cellular endocrinology
Hogg, Kirsten and Blair, John D and von Dadelszen, Peter and Robinson, Wendy P
2013

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array
Epigenetics & chromatin
2013

The human placenta methylome
Proceedings of the national academy of sciences
Schroeder, Diane I and Blair, John D and Lott, Paul and Yu, Hung On Ken and Hong, Danna and Crary, Florence and Ashwood, Paul and Walker, Cheryl and Korf, Ian and Robinson, Wendy P and others
2013

Response to“Response to Different measures of 'genome-wide' DNA methylation exhibit unique properties in placental and somatic tissues
Epigenetics
E. Magda Price, Wendy P. Robinson
DOI: 10.4161/epi.21623
08/2012

Different measures of “genome-wide” DNA methylation exhibit unique properties in placental and somatic tissues
Epigenetics
2012

Protein kinase profiling in miscarriage: implications for the pathogenesis of trisomic pregnancy.
Journal of obstetrics and gynaecology Canada: JOGC= Journal d'obstetrique et gynecologie du Canada: JOGC
Yong, PJ and McFadden, DE and Robinson, WP and others
2012

IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells
Placenta
Ackerman, WEt and Bulmer, JN and Carter, Anthony Michael and Chaillet, JR and Chamley, L and Chen, CP and Chuong, EB and Coleman, SJ and Collet, GP and Croy, BA and others
2012

DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF
Human reproduction
Hanna, Courtney W and Bloom, Michael S and Robinson, Wendy P and Kim, Dongsul and Parsons, Patrick J and vom Saal, Frederick S and Taylor, Julia A and Steuerwald, Amy J and Fujimoto, Victor Y
2012

Beckwith--Wiedemann syndrome in sibs discordant for IC2 methylation
American Journal of Medical Genetics Part A
2012

Absence of SYCP3 mutations in women with recurrent miscarriage with at least one trisomic miscarriage
Reproductive biomedicine online
Hanna, Courtney W and Blair, John D and Stephenson, Mary D and Robinson, Wendy P
2012

Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation
Human reproduction
2012

Prenatal and perinatal environmental influences on the human fetal and placental epigenome
Clinical Pharmacology & Therapeutics
Hogg, K and Price, EM and Hanna, CW and Robinson, WP
2012

Are we ready for DNA methylation-based prenatal testing?
Epigenomics
Ryan KC Yuen, Irina Manokhina, Wendy P Robinson
DOI: 10.2217/epi.11.62
08/2011

Aneuploidy and Polyploidy
The Placenta
Dan Diego-Alvarez, Wendy P. Robinson
DOI: 10.1002/9781444393927.ch35
03/2011

Aneuploidy and Polyploidy
The Placenta: From Development to Disease, From Development to Disease
Diego-Alvarez, Dan and Robinson, Wendy P
2011

Developmental origin of chorionic villus cultures from spontaneous abortion and chorionic villus sampling.
Journal of obstetrics and gynaecology Canada: JOGC= Journal d'obstetrique et gynecologie du Canada: JOGC
Yong, PJ and McFadden, DE and Robinson, WP
2011

Are we ready for DNA methylation-based prenatal testing?
Epigenomics
Yuen, Ryan KC and Manokhina, Irina and Robinson, Wendy P
2011

Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation
Human genetics
Cotton, Allison M and Lam, Lucia and Affleck, Joslynn G and Wilson, Ian M and Penaherrera, Maria S and McFadden, Deborah E and Kobor, Michael S and Lam, Wan L and Robinson, Wendy P and Brown, Carolyn J
2011

Extensive epigenetic reprogramming in human somatic tissues between fetus and adult
Epigenetics & chromatin
2011

Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies
Epigenetics & chromatin
2011

The utility of quantitative methylation assays at imprinted genes for the diagnosis of fetal and placental disorders
Clinical genetics
2011

TROPHOBLAST RESEARCH
Placenta
Carter, Anthony M and Staff, Anne Cathrine and Lash, Gendie E and Shiverick, Kathleen T and Miller, Richard K and Chamley, Larry and Clifton, Vicki and Harris, Lynda K and Katabuchi, Hidetaka and Keelan, Jeffrey and others
2011

Review: a high capacity of the human placenta for genetic and epigenetic variation: implications for assessing pregnancy outcome
Placenta
Yuen, RKC and Robinson, WP
2011

DNA methylation at H19/IGF2 ICR1 in the placenta of pregnancies conceived by in vitro fertilization and intracytoplasmic sperm injection
Fertility and sterility
Wong, Edgar Chan and Hatakeyama, Chiho and Robinson, Wendy P and Ma, Sai
2011

Placenta-specific expression of the interleukin-2 (IL-2) receptor $ß$ subunit from an endogenous retroviral promoter
Journal of Biological Chemistry
Cohen, Carla J and Rebollo, Rita and Babovic, Sonja and Dai, Elizabeth L and Robinson, Wendy P and Mager, Dixie L
2011

Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors
BMC genomics
Novakovic, Boris and Yuen, Ryan K and Gordon, Lavinia and Penaherrera, Maria S and Sharkey, Andrew and Moffett, Ashley and Craig, Jeffrey M and Robinson, Wendy P and Saffery, Richard
2011

Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage
Human reproduction
Hanna, Courtney W and Bretherick, Karla L and Liu, Chi-Chao and Stephenson, Mary D and Robinson, Wendy P
2010

Evaluating DNA methylation and gene expression variability in the human term placenta
Placenta
Avila, L and Yuen, RK and Diego-Alvarez, D and Penaherrera, MS and Jiang, R and Robinson, WP
2010

Methylation profiling in individuals with Russell--Silver syndrome
American Journal of Medical Genetics Part A
2010

Identification of copy number variants in miscarriages from couples with idiopathic recurrent pregnancy loss
Human reproduction
Rajcan-Separovic, E and Diego-Alvarez, D and Robinson, WP and Tyson, C and Qiao, Y and Harvard, C and Fawcett, C and Kalousek, D and Philipp, T and Somerville, MJ and others
2010

Fertility and aging: do reproductive-aged Canadian women know what they need to know?
Fertility and sterility
Bretherick, Karla L and Fairbrother, Nichole and Avila, Luana and Harbord, Sara HA and Robinson, Wendy P
2010

DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia
European Journal of Human Genetics
2010

Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia
Placenta
Bourque, DK and Avila, L and Penaherrera, M and Von Dadelszen, P and Robinson, WP
2010

Pseudohypoparathyroidism type 1a and the GNAS p. R231H mutation: somatic mosaicism in a mother with two affected sons
American Journal of Medical Genetics Part A
Ngai, Ying Fai and Chijiwa, Chieko and Mercimek-Mahmutoglu, Saadet and Stewart, Laura and Yong, Siu-Li and Robinson, Wendy P and Gibson, William T
2010

Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction
Prenatal diagnosis
2010

Telomere Length and Reproductive Aging
Obstetrical & Gynecological Survey
Courtney W. Hanna, Karla L. Bretherick, Jane L. Gair, Margo R. Fluker, Mary D. Stephenson, Wendy P. Robinson
DOI: 10.1097/01.ogx.0000359269.68606.cc
10/2009

Human Placental-Specific Epipolymorphism and its Association with Adverse Pregnancy Outcomes
PLoS ONE
Ryan K. C. Yuen, Luana Avila, Maria S. Peñaherrera, Peter von Dadelszen, Louis Lefebvre, Michael S. Kobor, Wendy P. Robinson
DOI: 10.1371/journal.pone.0007389
10/2009

A Genome-wide Search of Epigenetic Fetal DNA Markers for Non-invasive Prenatal Diagnosis of Aneuploidies
CHROMOSOME RESEARCH
Yuen, R and Penaherrera, M and von Dadelszen, P and Kobor, MS and Robinson, W
2009

Telornere Length and Reproductive Aging EDITORIAL COMMENT
Hanna, Courtney W and Bretherick, Karla L and Gair, Jane L and Fluker, Margo R and Stephenson, Mary D and Robinson, Wendy P
2009

Placental weight in pregnancies with trisomy confined to the placenta
J Obstet Gynaecol Can
Yong, Paul J and von Dadelszen, Peter and McFadden, Deborah E and Barrett, IJ and Kalousek, DK and Robinson, WP
2009

Telomere length and reproductive aging
Human Reproduction
Hanna, Courtney W and Bretherick, Karla L and Gair, Jane L and Fluker, Margo R and Stephenson, Mary D and Robinson, Wendy P
2009

Inactive X chromosome-specific reduction in placental DNA methylation
Human molecular genetics
Cotton, Allison M and Avila, Luana and Penaherrera, Maria S and Affleck, Joslynn G and Robinson, Wendy P and Brown, Carolyn J
2009

Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes
PloS one
2009

A skewed view of X chromosome inactivation
J. Clin. Invest.
Jakub Minks, Wendy P. Robinson, Carolyn J. Brown
DOI: 10.1172/jci34470
01/2008

MECP2 promoter methylation and X chromosome inactivation in autism
Autism Research
Nagarajan, Raman P and Patzel, Katherine A and Martin, Michelle and Yasui, Dag H and Swanberg, Susan E and Hertz-Picciotto, Irva and Hansen, Robin L and Van de Water, Judy and Pessah, Isaac N and Jiang, Ruby and others
2008

IGF2/H19 DMR methylation in placentas conceived by IVF or ICSI
Fertility and Sterility
Wong, E Chan and Hatakeyama, C and Robinson, WP and Ma, S
2008

Estrogen receptor $a$ gene polymorphisms are associated with idiopathic premature ovarian failure
Fertility and sterility
Bretherick, Karla L and Hanna, Courtney W and Currie, Lauren M and Fluker, Margo R and Hammond, Geoffrey L and Robinson, Wendy P
2008

Epigenetic alterations associated with premature ovarian failure
Fertility and Sterility
Ghahremani, Manda and Hanna, CW and Bretherick, KL and Penaherrera, MS and Fluker, Margo R and Robinson, Wendy P
2008

A skewed view of X chromosome inactivation
The Journal of clinical investigation
Minks, Jakub and Robinson, Wendy P and Brown, Carolyn J
2007

Origin and outcome of pregnancies affected by androgenetic/biparental chimerism
Human Reproduction
Robinson, Wendy P and Lauzon, Julie L and Innes, A Micheil and Lim, Ken and Arsovska, Snezana and McFadden, Deborah E
2007

Pregnancy and postnatal outcome of mosaic isochromosome 20q
Prenatal diagnosis
Robinson, WP and McGillivray, B and Friedman, JM
2007

Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15. 5
American Journal of Medical Genetics Part A
Robinson, WP and Slee, J and Smith, N and Murch, A and Watson, SK and Lam, WL and McFadden, DE
2007

Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage
Human Reproduction
Hirschfeld, AF and Jiang, R and Robinson, WP and McFadden, DE and Turvey, SE
2007

Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure
American Journal of Medical Genetics Part A
Bretherick, Karla L and Metzger, Daniel L and Chanoine, Jean-Pierre and Panagiotopoulos, Constadina and Watson, Spencer K and Lam, Wan L and Fluker, Margo R and Brown, Carolyn J and Robinson, Wendy P
2007

Phenotype of triploid embryos
Journal of medical genetics
McFadden, Deborah E and Robinson, WP
2006

Frequency of chromosomal abnormalities in spontaneous abortions derived from intracytoplasmic sperm injection compared with those from in vitro fertilization
Fertility and sterility
Ma, Sai and Philipp, Tom and Zhao, Yulian and Stetten, Gail and Robinson, Wendy P and Kalousek, Dagmar
2006

5 Postnatal follow-up of newborns from CPM16 pregnancies1
Three Chromosomes and a Baby: Cytogenetic, Biological, and Clinical Aspects of the Trisomic Placenta
Kalousek, D and Langlois, S and Robinson, W
2006

Postnatal follow-up of prenatally diagnosed trisomy 16 mosaicism
Prenatal diagnosis
Langlois, Sylvie and Yong, Paul J and Yong, Siu Li and Barrett, Irene and Kalousek, Dagmar K and Miny, Peter and Exeler, Rita and Morris, Kathy and Robinson, Wendy P
2006

P-159: Epigenetic analysis of H19/IGF2 in placentas from low birth weight (LBW) pregnancies following intracytoplasmic sperm injection (ICSI)
Fertility and Sterility
Hatakeyama, C and Robinson, WP and Ma, S
2006

334 PROTEIN KINASE EXPRESSION PROFILING IN HUMAN TRISOMY: GENE DOSAGE AND AMPLIFIED INSTABILITY.
Journal of Investigative Medicine
Yong, PJ and McFadden, DE and MacCalman, CD and Robinson, WP
2006

Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia
Journal of medical genetics
Kaiser-Rogers, Kathleen A and Mcfadden, Deborah E and Livasy, Chad A and Dansereau, Jerome and Jiang, Ruby and Knops, Judith F and Lefebvre, Louis and Rao, Kathleen W and Robinson, Wendy P
2006

The association between preeclampsia and placental trisomy 16 mosaicism
Prenatal diagnosis
Yong, Paul J and Langlois, Sylvie and Dadelszen, Peter von and Robinson, Wendy
2006

Prenatally detected trisomy 20 mosaicism
Prenatal diagnosis
Robinson, WP and McGillivray, B and Lewis, MES and Arbour, L and Barrett, I and Kalousek, DK
2005

X-chromosome inactivation and telomere size in newborns resulting from intracytoplasmic sperm injection
American Journal of Medical Genetics Part A
Robinson, WP and Penaherrera, MS and Gair, J and Hatakeyama, C and Ma, S
2005

FMR1 repeat sizes in the gray zone and high end of the normal range are associated with premature ovarian failure
Human genetics
Bretherick, Karla L and Fluker, Margo R and Robinson, Wendy P
2005

X-Chromosome Inactivation (XCI) in Newborns Conceived Through Intracytoplasmic Sperm Injection (ICSI)
Fertility and Sterility
Hatakeyama, C and Penaherrera, M and Robinson, W and Ma, S
2005

Recurrent trisomy 21: four cases in three generations
Clinical genetics
Gair, JL and Arbour, L and Rupps, R and Jiang, R and Bruyere, H and Robinson, WP
2005

18. Mosaicism
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
Robinson, Wendy P
2005

The association of skewed X chromosome inactivation with aneuploidy in humans
Cytogenetic and genome research
Bretherick, K and Gair, J and Robinson, WP
2005

Mosaicism
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
Wendy P. Robinson
DOI: 10.1002/047001153x.g102313
10/2004

The dynamics of X-inactivation skewing as women age
Clinical genetics
Hatakeyama, C and Anderson, CL and Beever, CL and Penaherrera, MS and Brown, CJ and Robinson, WP
2004

An association between sex chromosomal aneuploidy in sperm and an abortus with 45, X of paternal origin: possible transmission of chromosomal abnormalities through ICSI
Human Reproduction
Tang, SS and Gao, H and Robinson, WP and Yuen, B Ho and Ma, S
2004

EXTRAVILLUS TROPHOBLAST DIFFERENTIATION IN MISCARRIAGE.: 523
Journal of Investigative Medicine
Yong, PJ and McFadden, DE and MacCalman, CD and Robinson, WP
2004

Prenatally detected trisomy 4 and 6 mosaicism?cytogenetic results and clinical phenotype
Prenat. Diagn.
Dagmar Wieczorek, Eva C. Prott, Wendy P. Robinson, Eberhard Passarge, Gabriele Gillessen-Kaesbach
DOI: 10.1002/pd.557
2003

Skewed X-chromosome inactivation is associated with trisomy in women ascertained on the basis of recurrent spontaneous abortion or chromosomally abnormal pregnancies
The American Journal of Human Genetics
Beever, CL and Stephenson, MD and Penaherrera, MS and Jiang, RH and Kalousek, DK and Hayden, M and Field, L and Brown, CJ and Robinson, WP
2003

Clinical aspects, prenatal diagnosis, and pathogenesis of trisomy 16 mosaicism
Journal of medical genetics
Yong, PJ and Barrett, IJ and Kalousek, DK and Robinson, WP
2003

Methylation of ZNF261 as an assay for determining X chromosome inactivation patterns
American Journal of Medical Genetics Part A
2003

ICSI and the transmission of X-autosomal translocation: a three-generation evaluation of X; 20 translocation: Case report
Human Reproduction
Ma, Sai and Yuen, Basil Ho and Penaherrera, Maria and Koehn, David and Ness, Larry and Robinson, Wendy
2003

Prenatally detected trisomy 4 and 6 mosaicism—cytogenetic results and clinical phenotype
Prenatal diagnosis
Wieczorek, Dagmar and Prott, Eva C and Robinson, Wendy P and Passarge, Eberhard and Gillessen-Kaesbach, Gabriele
2003

Cytogenetic and molecular study of a premature male infant with 46, XX derived from ICSI: case report
Human Reproduction
Ma, S and Tang, SS and Yuen, B Ho and Bruyere, H and Penaherrera, M and Robinson, WP
2003

X-chromosome inactivation (XCI) patterns in placental tissues of a paternally derived bal t (X; 20) case
American Journal of Medical Genetics Part A
Penaherrera, MS and Ma, S and Ho Yuen, B and Brown, CJ and Robinson, WP
2003

A correlation between sex chromosomal aneuploidy in sperm and an abortus with 45, X of paternal origin: evidence of transmission of chromosomal abnormalities through ICSI
Fertility and Sterility
Tang, Steven S and Gao, HJ and Robinson, WP and Yuen, B Ho and Ma, SSY
2003

Developmental origin of cultured chorionic villi: implications for cytogenetics.
AMERICAN JOURNAL OF HUMAN GENETICS
Yong, PJ and McFadden, DE and MacCalman, CD and Robinson, WP
2003

Frequency of chromosomal abnormalities in abortuses from ICSI and IVF
HUMAN REPRODUCTION
Ma, S and Zhao, Y and Philipp, T and Yuen, Ho B and Stetten, G and Garcia, J and Robinson, W and Kalousek, D
2003

X inactivation skewing patterns change as women age.
AMERICAN JOURNAL OF HUMAN GENETICS
Anderson, CL and Hatakeyama, C and Beever, CL and Hayden, M and Casey, B and Brown, CJ and Robinson, WP
2003

Molecular Detection of Uniparental Disomy
Molecular Cytogenetics: Protocols and Applications
Robinson, Wendy P
2003

Determination of birth weight in confined placental mosaicism.
JOURNAL OF INVESTIGATIVE MEDICINE
Yong, PJ and Kalousek, DK and Barrett, IJ and Robinson, WP
2003

Skewed X-chromosome inactivation in premature ovarian failure.
AMERICAN JOURNAL OF HUMAN GENETICS
Bretherick, KL and Fluker, MR and Beever, CL and Anderson, CL and Brown, CJ and Robinson, WP
2003

Does recurrent euploid and non-euploid miscarriage exist?
HUMAN REPRODUCTION
Graham, J and Robinson, W and Stephenson, M
2003

Is telomere length associated with trisomy risk in humans?
AMERICAN JOURNAL OF HUMAN GENETICS
Gair, J and Chavez, E and Stephenson, M and Langlois, S and Lansdorp, P and Robinson, W
2003

X chromosome inactivation patterns in Russell--Silver syndrome patients and their mothers
American Journal of Medical Genetics Part A
2003

X-Chromosome inactivation (XCI) patterns in placental tissues of a paternally derived bal t(X;20) case
Fertility and Sterility
Maria Penaherrea, Sai Ma, Basil Ho Yuen, Carolyn Brown, Wendy Robinson
DOI: 10.1016/s0015-0282(02)04085-2
09/2002

Skewed XCl in women experiencing a pregnancy with meiotic nondisjunction.
AMERICAN JOURNAL OF HUMAN GENETICS
Penaherrera, MS and Beever, CL and Jiang, RH and McFadden, DE and Hayden, MR and Field, LL and Kalousek, DK and Brown, CJ and Robinson, WP
2002

Preeclampsia and confined placental mosaicism.
AMERICAN JOURNAL OF HUMAN GENETICS
Yong, PJ and Langlois, S and von Dadelszen, P and Barrett, IJ and Kalousek, DK and Robinson, WP
2002

Evidence for imprinting on chromosome 16: the effect of uniparental disomy on the outcome of mosaic trisomy 16 pregnancies
American journal of medical genetics
Yong, PJ and Marion, SA and Barrett, IJ and Kalousek, DK and Robinson, WP
2002

Dispermy—origin of diandric triploidy Brief Communication
Human Reproduction
McFadden, Deborah E and Jiang, Ruby and Langlois, Sylvie and Robinson, Wendy P
2002

Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism
Prenatal diagnosis
2002

Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case--control study
Human Reproduction
Stephenson, MD and Awartani, KA and Robinson, WP
2002

A rare case of mosaicism for paternal UPD 9 in a dizygotic twin pregnancy.
AMERICAN JOURNAL OF HUMAN GENETICS
Kaiser-Rogers, KA and Robinson, WP and Knops, JF and Vargo, D and Livasy, CA and Bailit, J and Rao, KW
2002

Brief Communication Dispermy—origin of diandric triploidy
Human Reproduction
McFadden, Deborah E and Jiang, Ruby and Langlois, Sylvie and Robinson, Wendy P
2002

X-Chromosome inactivation (XCI) patterns in placental tissues of a paternally derived bal t (X; 20) case
Fertility and Sterility
Penaherrea, Maria and Ma, Sai and Yuen, Basil Ho and Brown, Carolyn and Robinson, Wendy
2002

Chromosomal Genetic Disease: Numerical Aberrations
Encyclopedia of Life Sciences
Wendy P Robinson, Deborah E McFadden
DOI: 10.1038/npg.els.0001451
09/2001

Cytogenetic investigation of fetuses and infants conceived through intracytoplasmic sperm injection
Fertility and sterility
Lam, Ryan and Ma, Sai and Robinson, Wendy P and Chan, Theresa and Yuen, Basil Ho
2001

Two cases of confined placental mosaicism for chromosome 4, including one with maternal uniparental disomy
Prenatal diagnosis
Kuchinka, BD and Barrett, IJ and Moya, G and Sanchez, JM and Langlois, S and Yong, S-L and Kalousek, DK and Robinson, WP
2001

Skewed X inactivation and recurrent spontaneous abortion.
Seminars in reproductive medicine
Robinson, WP and Beever, C and Brown, CJ and Stephenson, MD
2001

The origin of abnormalities in recurrent aneuploidy/polyploidy
The American Journal of Human Genetics
Robinson, WP and McFadden, DE and Stephenson, MD
2001

Cytogenetic investigation of fetuses and infants conceived through intracytoplasmic sperm injection
Fertility and Sterility
Ryan Lam, Sai Ma, Wendy P Robinson, Theresa Chan, Basil Ho Yuen
DOI: 10.1016/s0015-0282(01)02873-4
2001

Recurrent trisomy 15 in a female carrier of der (15) t (Y; 15)(q12; p13)
American journal of medical genetics
Rajcan-Separovic, Evica and Robinson, Wendy P and Stephenson, Mary and Pantzar, Tapio and Arbour, Laura and McFadden, Deborah and Guscott, Janet
2001

Maternal origin of monosomy 21 derived from ICSI
Human Reproduction
Ma, Sai and Robinson, Wendy and Lam, Ryan and Yuen, Basil Ho
2001

Prenatal diagnosis, outcome and imprinting in mosaic trisomy 16 pregnancies.
AMERICAN JOURNAL OF HUMAN GENETICS
Yong, PJ and Barrett, I and Kalousek, DK and Robinson, WP
2001

The origin of abnormalities in recurrent aneuploidy.
AMERICAN JOURNAL OF HUMAN GENETICS
Robinson, WP and McFadden, DE and Stephenson, MS
2001

Cytogenetic analysis of miscarriages of couples with recurrent miscarriage: a case-control study.
Fertility and Sterility
Awartani, KA and Robinson, WP and Stephenson, MD
2001

Distribution of exchanges in chromosome 15 nondisjunction.
AMERICAN JOURNAL OF HUMAN GENETICS
Gair, JL and Kuchinka, BD and Robinson, WP
2001

Cytogenetic investigation of fetuses and infants derived from intracytoplasmic sperm injection.
Fertility and Sterility
Ma, S and Lam, R and Robinson, WP and Chan, T and Yuen, B Ho
2001

Incomplete methylation of the inactivated X-chromosome in human chorionic villous samples.
AMERICAN JOURNAL OF HUMAN GENETICS
Penaherrera, MS and McDonald, HL and Brown, CJ and Robinson, WP
2001

Variability in DNA methylation assays of X chromosome inactivation (XCI).
AMERICAN JOURNAL OF HUMAN GENETICS
Beever, CL and Jiang, RH and Brown, CJ and Robinson, WP
2001

Statistical analysis of uniparental disomy data using hidden Markov models
Biometrics
Zhao, H and Li, J and Robinson, WP
2001

Grandmaternal origin of an isochromosome 18p present in two maternal half-sisters
American journal of medical genetics
Boyle, Jane and Sangha, Karan and Dill, Fred and Robinson, Wendy P and Yong, Siu-Li
2001

Multipoint Genetic Mapping with Uniparental Disomy Data
The American Journal of Human Genetics
Hongyu Zhao, Jinming Li, Wendy P. Robinson
DOI: 10.1086/303072
10/2000

Mechanisms leading to uniparental disomy and their clinical consequences
Bioessays
Wendy P. Robinson
DOI: 10.1002/(sici)1521-1878(200005)22:53.3.co;2-b
05/2000

Mechanisms leading to uniparental disomy and their clinical consequences
Bioessays
Wendy P. Robinson
DOI: 10.1002/(sici)1521-1878(200005)22:53.0.co;2-k
04/2000

No association between an MTHFR polymorphism and occurrence of aneuploidy.
AMERICAN JOURNAL OF HUMAN GENETICS
Kuchinka, BD and Oppenheim, LN and Henderson, LJ and Stephenson, MD and Robinson, WP
2000

Gene conversion in the 15q imprinting center: Molecular evidence for homologous association of Imprinted chromosomal domains.
AMERICAN JOURNAL OF HUMAN GENETICS
Horsthemke, B and Gross, S and Robinson, W and Buiting, K
2000

Mechanisms leading to uniparental disomy and their clinical consequences
Bioessays
Robinson, Wendy P
2000

Multipoint genetic mapping with uniparental disomy data
The American Journal of Human Genetics
Zhao, Hongyu and Li, Jinming and Robinson, Wendy P
2000

The causes and consequences of random and non-random X chromosome inactivation in humans
Clinical genetics
Brown, CJ and Robinson, WP
2000

Diagnosis of maternal uniparental disomy of chromosome 7 with a methylation specific PCR assay
Journal of medical genetics
Kosaki, Kenjiro and KOSAKI, RIKA and ROBINSON, WENDY P and CRAIGEN, WILLIAM J and SHAFFER, LISA G and SATO, SEIJI and MATSUO, NOBUTAKE
2000

An association between skewed X-chromosome inactivation and abnormal outcome in mosaic trisomy 16 confined predominantly to the placenta
Clinical genetics
Penaherrera, MS and Barrett, IJ and Brown, CJ and Langlois, S and Yong, S-L and Lewis, S and Bruyere, H and Howard-Peebles, PN and Kalousek, DK and Robinson, WP
2000

Recurrent trisomy 21 in a couple with a child presenting trisomy 21 mosaicism and maternal uniparental disomy for chromosome 21 in the euploid cell line
American journal of medical genetics
2000

Characteristics of Women with Recurrent Miscarriage (RM) and Skewed X-Chromosome Inactivation (XCI)
Fertility and Sterility
Stephenson, MD and Beever, CL and Robinson, WP
2000

Clinical associations of women experiencing recurrent spontaneous abortion (RSA) and exhibiting skewed X chromosome inactivation (XCI).
AMERICAN JOURNAL OF HUMAN GENETICS
Beever, CL and Stephenson, MD and Popovska, V and Jiang, R and Sangha, KK and Ochnio, K and Brown, CJ and Robinson, WP
2000

Proximal deletion breakpoints in 15q11-q13 are sites of high homologous recombination.
AMERICAN JOURNAL OF HUMAN GENETICS
Gair, JL and Kuchinka, BD and Lalande, M and Ritchie, RJ and Robinson, WP
2000

Somatic segregation errors predominantly contribute to the gain or loss of a paternal chromosome leading to uniparental disomy for chromosome 15
Clinical genetics
2000

Statistical methods for human nondisjunction data.
AMERICAN JOURNAL OF HUMAN GENETICS
Li, J and Zhao, H and Sherman, SL and Robinson, WP
2000

Frequency of meiotic trisomy depends on involved chromosome and mode of ascertainment
American journal of medical genetics
Robinson, WP and Bernasconi, F and Lau, A and McFadden, DE
1999

X chromosome inactivation studies in mosaic trisomies.
AMERICAN JOURNAL OF HUMAN GENETICS
Penaherrera, MS and Barrett, IJ and Brown, CJ and Kalousek, DK and Robinson, WP
1999

Sex chromosome complement of placental trophoblast in X chromosome aneuploid pregnancies.
AMERICAN JOURNAL OF HUMAN GENETICS
Barrett, IJ and Robinson, WP and Kalousek, DK
1999

Tissue specific involvement in fetal trisomy 16.
American Journal of Human Genetics
Bruyere, H and Barrett, IJ and Kalousek, DK and Robinson, WP
1999

Diagnosis of maternal UPD 7 by methylation specific PCR.
AMERICAN JOURNAL OF HUMAN GENETICS
Kosaki, R and Kosaki, K and Robinson, W and Shaffer, L and Craigen, W and Matsuo, N
1999

Clinical and molecular findings in two patients with Russell-Silver syndrome and UPD7: Comparison with non-UPD7 cases
American journal of medical genetics
Bernard, LE and Penaherrera, MS and Van Allen, MI and Wang, MS and Yong, S-L and Gareis, F and Langlois, S and Robinson, WP
1999

Molecular and clinical correlation study of Williams-Beuren syndrome: No evidence of molecular factors in the deletion region or imprinting affecting clinical outcome
American journal of medical genetics
Wang, Michael S and Schinzel, Albert and Kotzot, Dieter and Balmer, Damina and Casey, Robin and Chodirker, Bernie N and Gyftodimou, Jolanda and Petersen, Michael B and Lopez-Rangel, Elana and Robinson, Wendy P
1999

Report of the fourth international workshop on human chromosome 15 mapping 1997
Cytogenetic and Genome Research
Morton, Cynthia C and Christian, SL and Donlon, TA and Driscoll, DJ and Fink, JK and Gabriel, JM and Gotway, G and Greally, JM and Hitchins, MP and Howard, HC and others
1999

Extremely skewed X chromosome inactivation is increased in women with recurrent spontaneous abortion.
AMERICAN JOURNAL OF HUMAN GENETICS
Robinson, WP and Sangha, KK and Stephenson, MD and Ochnio, K and Brown, CJ
1999

Extremely skewed X-chromosome inactivation is increased in women with recurrent spontaneous abortion.
American journal of human genetics
Sangha, Karan K and Stephenson, Mary D and Brown, Carolyn J and Robinson, Wendy P
1999

The mechanisms involved in formation of deletions and duplications of 15q11-q13.
Journal of medical genetics
Robinson, WP and Dutly, F and Nicholls, RD and Bernasconi, F and Penaherrera, M and Michaelis, RC and Abeliovich, D and Schinzel, AA
1998

Maternal meiosis I non-disjunction of chromosome 15: dependence of the maternal age effect on level of recombination
Human molecular genetics
1998

Partial tetrasomy with triplication of chromosome (5)(p14-p15. 33) in a patient with severe multiple congenital anomalies
American journal of medical genetics
Harrison, Karen J and Teshima, Ikuko E and Silver, Meredith M and Jay, Venita and Unger, Sheila and Robinson, Wendy P and James, Andrew and Levin, Alex and Chitayat, David
1998

Maternal uniparental disomy of chromosome 1 with no apparent phenotypic effects.
American journal of human genetics
Field, L Leigh and Tobias, Rose and Robinson, Wendy P and Paisey, Richard and Bain, Stephen
1998

XIST expression and X-chromosome inactivation in human preimplantation embryos.
American journal of human genetics
Brown, Carolyn J and Robinson, Wendy P
1997

Meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction.
American journal of human genetics
Robinson, WP and Barrett, IJ and Bernard, L and Telenius, A and Bernasconi, F and Wilson, RD and Best, RG and Howard-Peebles, PN and Langlois, S and Kalousek, DK
1997

A meiotic origin of trisomy in pregnancies with confined placental mosaicism is correlated with increased risk of fetal intrauterine growth retardation and uniparental disomy
LABORATORY INVESTIGATION
Kalousek, DK and Robinson, WP and Barrett, I and Telenius, A and Wilson, RD and HowardPeebles, PN and Langlois, S
1997

Report of the third international workshop on human chromosome 15 mapping 1996
Cytogenetic and Genome Research
Robinson, Wendy and Knoll, Joan
1997

Mosaicism between maternal heterodisomy 16 and maternal heterodisomy 16p13-> qter combined with trisomy 16pter-> p13 associated with mental retardation and multiple anomalies.
CYTOGENETICS AND CELL GENETICS
Brecevic, L and Kotzot, D and Binkert, F and Robinson, W and Dutly, F and Ausserer, B and Schinzel, AA
1997

X chromosome inactivation patterns in human placenta.
AMERICAN JOURNAL OF HUMAN GENETICS
Penaherrera, MS and Lau, AW and Brown, CJ and Wilson, RD and Barrett, IJ and Kalousek, DK and Robinson, WP
1997

Association of prenatally diagnosed confined placental mosaicism (CPM) and fetal gonadal mosaicism.
AMERICAN JOURNAL OF HUMAN GENETICS
Stavropoulos, DJ and Barrett, IJ and Lomax, BL and Bick, D and Bernasconi, F and Robinson, WP and Kalousek, DK
1997

Report of the Third International Workshop on Human Chromosome 15 Mapping 1996
Cytogenet Cell Genet
Wendy Robinson, Joan Knoll
DOI: 10.1159/000134500
1997

Skewed X-chromosome inactivation is common in fetuses or newborns associated with confined placental mosaicism
The American Journal of Human Genetics
Lau, Aster W and Brown, Carolyn J and Penaherrera, Maria and Langlois, Sylvie and Kalousek, Dagmar K and Robinson, Wendy P
1997

Skewed X-chromosome inactivation is common in fetuses or newborns associated with confined placental mosaicism.
AMERICAN JOURNAL OF HUMAN GENETICS
Robinson, WP and Lau, AW and Brown, CJ and Langlois, S and Kalousek, DK
1997

Maternal age and recombination distribution associated with chromosome 15 nondisjunction.
AMERICAN JOURNAL OF HUMAN GENETICS
Kuchinka, BD and Hassold, TJ and Horsthemke, B and Langlois, S and Ledbetter, DH and Michaelis, RC and Schinzel, A and Schuffenhauer, S and Robinson, WP
1997

Novel case of del (17)(q23. 1q23. 3) further highlights a recognizable phenotype involving deletions of chromosome (17)(q21q24)
American journal of medical genetics
Mickelson, Elizabeth CR and Robinson, Wendy P and Hrynchak, Monica A and Lewis, ME
1997

Maternal uniparental disomy of chromosome 2 and confined placental mosaicism for trisomy 2 in a fetus with intrauterine growth restriction, hypospadias, and oligohydramnios
Prenatal diagnosis
HANSEN, WENDY F and BERNARD, LYNN E and LANGLOIS, SYLVIE and RAO, KATHLEEN W and CHESCHEIR, NANCY C and AYLSWORTH, ARTHUR S and SMITH, D and ROBINSON, WENDY P and BARRETT, IRENE J and KALOUSEK, DAGMAR K
1997

CYTOGENETIC AND AGE-DEPENDENT RISK FACTORS ASSOCIATED WITH UNIPARENTAL DISOMY 15
Prenatal diagnosis
Robinson, WP and Langlois, S and Schuffenhauer, S and Horsthemke, B and Michaelis, RC and Christian, S and Ledbetter, DH and Schinzel, A
1996

Delineation of 7q11. 2 deletions associated with Williams--Beuren syndrome and mapping of a repetitive sequence to within and to either side of the common deletion
Genomics
Robinson, WP and Waslynka, J and Bernasconi, F and Wang, M and Clark, S and Kotzot, D and Schinzel, A
1996

Comparison of phenotype in uniparental disomy and deletion Prader-Willi syndrome: Sex specific differences
American journal of medical genetics
Mitchell, John and Schinzel, Albert and Langlois, Sylvie and Gillessen-Kaesbach, Gabriele and Schuffenhauer, Simone and Michaelis, Ron and Abeliovich, Dvorah and Lerer, Isabel and Christian, Susan and Guitart, Miriam and others
1996

Trisomy first, translocation second, uniparental disomy and partial trisomy third: a new mechanism for complex chromosomal aneuploidy.
European journal of human genetics: EJHG
Schinzel, A and Kotzot, D and Brecevic, L and Robinson, WP and Dutly, F and Dauwerse, H and Binkert, F and Baumer, A and Ausserer, B
1996

Mosaicism most likely accounts for extended survival of trisomy 22
American journal of medical genetics
Robinson, Wendy P and Kalousek, Dagmar K
1996

Phenotype of maternal UPD(14)
Am. J. Med. Genet.
Wendy P. Robinson, Sylvie Langlois
DOI: 10.1002/(sici)1096-8628(19961202)66:13.0.co;2-l
1996

Analysis of nine pregnancies with confined placental mosaicism for trisomy 2
Prenatal diagnosis
Shaffer, LG and Langlois, S and McCaskill, C and Main, DM and Robinson, WP and Barrett, IJ and Kalousek, DK
1996

Phenotype of maternal UPD (14)
American journal of medical genetics
Robinson, Wendy P and Langlois, Sylvie
1996

The origin of maternal uniparental disomy 15.
AMERICAN JOURNAL OF MEDICAL GENETICS
Robinson, WP and Langlois, S and Bernasconi, F and Clark, S and Christian, S and Ledbetter, DH and GillessenKaesbach, G and Horsthemke, B and Lerer, I and Abeliovich, D and others
1996

A comparison of phenotype in patients with Prader-Willi syndrome (PWS) resulting from interstitial deletion and uniparental disomy.
AMERICAN JOURNAL OF MEDICAL GENETICS
Mitchell, J and Langlois, S and GillessenKaesbach, G and Horsthemke, B and Michaelis, R and Schinzel, AA and Abelovich, S and Lerer, I and Schuffenhauer, S and Guitart, M and others
1996

The extent, mechanism, and consequences of genetic variation, for recombination rate.
American journal of human genetics
Robinson, Wendy P
1996

Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency.
American journal of human genetics
Benlian, Pascale and Foubert, Luc and Gagne, Eric and Bernard, Lynn and De Gennes, JL and Langlois, Sylvie and Robinson, Wendy and Hayden, Michael
1996

Molecular studies of translocations and trisomy involving chromosome 13
American journal of medical genetics
Robinson, WP and Bernasconi, F and Dutly, F and Lefort, G and Romain, DR and Binkert, F and Schinzel, AA
1996

Trisomy 7 CVS mosaicism: pregnancy outcome, placental and DNA analysis in 14 cases
American journal of medical genetics
Kalousek, DK and Langlois, S and Robinson, WP and Telenius, A and Bernard, L and Barrett, IJ and Howard-Peebles, PN and Wilson, RD
1996

Phenotype of the Williams-Beuren syndrome associated with hemizygosity at the elastin locus
European journal of pediatrics
Kotzot, D and Bernasconi, F and Brecevic, L and Robinson, WP and Kiss, P and Kosztolanyi, G and Lurie, IW and Superti-Furga, A and Schinzel, A
1995

Molecular studies of chromosomal mosaicism: relative frequency of chromosome gain or loss and possible role of cell selection.
American journal of human genetics
Robinson, WP and Binkert, F and Bernasconi, F and Lorda-Sanchez, I and Werder, EA and Schinzel, AA
1995

Genotype-phenotype correlation in a series of 167 deletion and non-deletion patients with Prader-Willi syndrome
Human genetics
Gillessen-Kaesbach, Gabriele and Robinson, Wendy and Lohmann, Dietmar and Kaya-Westerloh, Sabine and Passarge, Eberhard and Horsthemke, Bernhard
1995

Molecular characterization of two proximal deletion breakpoint regions in both Prader-Willi and Angelman syndrome patients.
American journal of human genetics
Christian, SL and Robinson, WP and Huang, B and Mutirangura, A and Line, MR and Nakao, Mitsuyoshi and Surti, U and Chakravarti, A and Ledbetter, DH
1995

Uniparental disomy 7 in Silver—Russell syndrome and primordial growth retardation
Human molecular genetics
1995

THE ORIGIN OF TRISOMY CONFINED TO THE PLACENTA
AMERICAN JOURNAL OF HUMAN GENETICS
ROBINSON, WP and LANGLOIS, S and BARRETT, I and CLARK, S and BERNARD, L and KALOUSEK, DK
1995

Sex-specific meiotic recombination in the Prader—Willi/Angelman syndrome imprinted region
Human molecular genetics
Robinson, Wendy P and Lalande, Marc
1995

Kallmann syndrome in a boy with at (1; 10) translocation detected by reverse chromosome painting.
Journal of medical genetics
Schinzel, Albert and Lorda-Sanchez, Isabel and Binkert, Franz and Carter, NP and Bebb, CE and Ferguson-Smith, Malcolm A and Eiholzer, Urs and Zachmann, Milo and Robinson, Wendy P
1995

Detection of aberrant DNA methylation in unique Prader—Willi syndrome patients and its diagnostic implications
Human molecular genetics
1994

Intrachromosomal triplication of 15q11-q13.
Journal of medical genetics
Schinzel, AA and Brecevic, L and Bernasconi, F and Binkert, F and Berthet, F and Wuilloud, A and Robinson, WP
1994

A somatic origin of homologous Robertsonian translocations and isochromosomes
American journal of human genetics
1994

Angelman syndrome due to paternal uniparental disomy of chromosome 15: a milder phenotype?
American journal of medical genetics
Bottani, Armand and Robinson, WP and Delozier-Blanchet, CD and Engel, E and Morris, MA and Schmitt, B and Thun-Hohenstein, L and Schinzel, A
1994

Angelman Syndrome due to paternal uniparental disomy of chromosome 15
Bottani, A
1994

Molecular studies of free and translocation trisomy
American Journal of Human Genetics
Robinson, WP and Bernasconi, F and Lefort, G
1994

An interstitial deletion of proximal 8q (q11-q13) in a girl with Silver-Russell syndrome-like features.
Clinical dysmorphology
Schinzel, AA and Robinson, WP and Binkert, F and Fanconi, A
1994

Multiple origins of X chromosome tetrasomy.
Journal of medical genetics
Robinson, WP and Binkert, F and Schinzel, AA and Basaran, S and Mikelsaar, R
1994

DETECTION OF ABERRANT DNA METHYLATION IN UNIQUE PRADER-WILLI-SYNDROME PATIENTS AND ITS DIAGNOSTIC IMPLICATIONS (VOL 3, PG 893, 1994)
HUMAN MOLECULAR GENETICS
BUITING, K and DITTRICH, B and ROBINSON, WP and GUITART, M and ABELIOVICH, D and LERER, I and HORSTHEMKE, B
1994

Fine Mapping of 5 Additional Short Tandem Repeats (Strs) within the Prader Willi/Angelman Syndrome Critical Region on Chromosome 15q11. 2-12
Journal of Cellular Biochemistry
Christian, SL and Mutirangura, A and Robinson, WP and Nakao, M and Beaudet, AL and Ledbetter, DH
1994

RECOMBINATION IN THE PERICENTROMERIC REGION OF CHROMOSOME 15Q
CYTOGENETICS AND CELL GENETICS
ROBINSON, WP and CHRISTIAN, SL and LEDBETTER, DH and SCHINZEL, AA
1994

Maternal uniparental disomy 22 has no impact on the phenotype.
American journal of human genetics
1994

Fine Mapping of 8 Additional Short Tandem Repeats (Strs) and Expansion of the Yac Contig within the Prader-Willi-Angelman-Syndrome Critical Region on Chromosome-15q11. 2-] Q12
Cytogenetics and Cell Genetics
Christian, SL and Robinson, WP and Mutirangura, A and Nakao, M and Beaudet, AL and Ledbetter, DH
1994

Robertsonian translocations between homologous chromosomes are somatic events
AMERICAN JOURNAL OF HUMAN GENETICS
Robinson, WP and Bernasconi, F and Blouin, JL and BASARAN, S and NERI, G and ZIZKA, J and ANTONARAKIS, SE and SCHINZEL, AA
1993

DUPLICATION OF CHROMOSOME-15Q IN PRADER-WILLI AND ANGELMAN SYNDROMES-A GENE DOSAGE PARADOX
AMERICAN JOURNAL OF HUMAN GENETICS
Mutirangura, A and Kuwano, A and Robinson, WP and Greenberg, F and Malcolm, S and Ledbetter, DH
1993

Modification of 15q11—q13 DNA methylation imprints in unique Angelman and Prader—Willi patients
Human molecular genetics
Glenn, Christopher C and Nicholls, Robert D and Robinson, Wendy P and Saitoh, Shinjl and Nllkawa, Norlo and Schlnzel, Albert and Horsthemke, Bernhard and Driscoll, Daniel J
1993

Nondisjunction of chromosome 15: origin and recombination.
American journal of human genetics
Robinson, WP and Bernasconi, F and Mutirangura, A and Ledbetter, DH and Langlois, S and Malcolm, S and Morris, MA and Schinzel, AA
1993

Uniparental disomy explains the occurrence of the Angelman or Prader-Willi syndrome in patients with an additional small inv dup (15) chromosome.
Journal of medical genetics
Robinson, Wendy P and Wagstaff, Joseph and Bernasconi, Fabiana and Baccichetti, Carlo and Artifoni, Lina and Franzoni, Emilio and Suslak, Lorraine and Shih, Ling-Yu and Aviv, Hannah and Schinzel, Albert A
1993

Homozygous parent affected sib pair method for detecting disease predisposing variants: application to insulin dependent diabetes mellitus
Genetic epidemiology
Robinson, Wendy P and Barbosa, Jose and Rich, Steven S and Thomson, Glenys
1993

Molecular definition of the Prader—Willi syndrome chromosome region and orientation of the SNRPN gene
Human molecular genetics
1993

Parental origin of the supernumerary chromosome in trisomy 18
Clinical genetics
Ya-gang, Xie and Robinson, Wendy P and Spiegel, Roland and Binkert, Franz and Ruefenacht, Urszula and Schinzel, Albert A
1993

Exclusively paternal X chromosomes in a girl with short stature
Human genetics
Schinzel, Albert A and Robinson, Wendy P and Binkert, Franz and Torresani, Toni and Werder, Edmond A
1993

Deletion breakpoints associated with the Prader-Willi and Angelman syndromes (15q11-q13) are not sites of high homologous recombination
Human genetics
Robinson, Wendy P and Spiegel, Roland and Schinzel, Albert A
1993

Prader-Willi or Angelman syndrome in familial 15q11¿ q13 deletion of maternal origin?
Human genetics
Schinzel, Albert and Robinson, Wendy P and Bottani, Armand and Yagang, Xie and Prader, Andrea
1992

Increased parental ages and uniparental disomy 15: a paternal age effect?
European journal of human genetics: EJHG
Robinson, WP and Lorda-Sanchez, I and Malcolm, S and Langlois, S and Schuffenhauer, S and Knoblauch, H and Horsthemke, B and Schinzel, AA
1992

Clinical, molecular, and cytogenetic survey of potential Prader-Willi syndrome patients
Prader-Willi Syndrome
1992

Reduced recombination and paternal age effect in Klinefelter syndrome
Human genetics
Lorda-Sanchez, Isabel and Binkert, Franz and Maechler, Marco and Robinson, Wendy P and Schinzel, Albert A
1992

Clinical and molecular analysis of five inv dup (15) patients.
European journal of human genetics: EJHG
1992

Molecular diagnosis of the Prader-Willi and Angelman syndromes by detection of parent-of-origin specific DNA methylation in 15q11-13
Human genetics
1992

C2. B. 8 Reading disequilibrium patterns
HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference, Held in Yokohama, Japan, 6-13 November, 1991
THOMSON, GLENYS and KLITZ, WILLIAM and ROBINSON, WENDY
1992

Small nuclear ribonucleoprotein polypeptide N (SNRPN), an expressed gene in the Prader--Willi syndrome critical region
Nature genetics
1992

Selection, hitchhiking and disequilibrium analysis at three linked loci with application to HLA data.
Genetics
Robinson, Wendy P and Cambon-Thomsen, Anne and Borot, Nicolas and Klitz, W and Thomson, G
1991

Population genetics of HLA
Evolution at the molecular level
Hedrick, Philip W and Klitz, William and Robinson, Wendy P and Kuhner, Mary K and Thomson, Glenys
1991

Three-locus systems impose additional constraints on pairwise disequilibria.
Genetics
Robinson, Wendy P and Asmussen, MA and Thomson, G
1991

Molecular, cytogenetic, and clinical investigations of Prader-Willi syndrome patients.
American journal of human genetics
1991

Familial congenital laryngeal abductor paralysis: different expression in a family with one male and three females affected.
Journal of medical genetics
Schinzel, A and Hof, Erika and Dangel, P and Robinson, Wendy
1990

HLA--Bw60 increases susceptibility to ankylosing spondylitis in HLA--B27+ patients
Arthritis & Rheumatism
Robinson, Wendy P and Van Der Linden, Sjef M and Khan, Muhammad A and Rentsch, Hans-Ueli and Cats, Arnold and Russell, Anthony and Thomson, Glenys
1989

HLA and insulin gene associations with IDDM
Genetic epidemiology
Thomson, G and Robinson, WP and Kuhner, MK and Joe, S and Klitz, W
1989

Affected sib pair IBS methods: detection of linkage and genetic models.
Progress in clinical and biological research
Motro, Uzi and Thomson, Glenys and Kuhner, Mary K and Robinson, Wendy P
1989

Population genetic analysis of selection and disease associations at the HLA gene family
Robinson, Wendy Paige
1989

Clues to IDDM pathogenesis from genetic and serological traits in multiply affected families
Genetic epidemiology
Klitz, William and Kuhner, Mary K and Robinson, Wendy and Esposito, Michael and Thomson, Glenys
1989

Clues to IDDM pathogenesis from genetic and serological traits in multiply affected familiesClues to IDDM Causation
Genet. Epidemiol.
William Klitz, Mary K. Kuhner, Wendy Robinson, Michael Esposito, Glenys Thomson
DOI: 10.1002/gepi.1370060122
1989

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus
American journal of human genetics
1988

Disease associations and disequilibrium mapping.
Progress in clinical and biological research
Robinson, Wendy P and Kramer, Patricia and Payami, Haydeh and Motro, Uzi and Esposito, Michael S and Thomson, Glenys
1988

Molecular Detection of Uniparental Disomy
Molecular Cytogenetics
Wendy P. Robinson
DOI: 10.1385/1-59259-300-3:291

Chromosomal Genetic Disease: Numerical Aberrations
eLS
Robinson, Wendy P and McFadden, Deborah E

Characterizing the hypomethylated DNA methylation profile of nucleated red blood cells from cord blood
Epigenomics
PubMed: 27687885

Mosaicism
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
Robinson, Wendy P

Letters to JMG
Green, A and McIntosh, I and Cenarro, A and Artieda, M and Castillo, S and Mozas, P and Reyes, G and Tejedor, D and Alonso, R and Mata, P and others

Research

Genomics and epigenomics of development
The maternal environment (stress, inflammation, diet, etc.) can lead to both short- and long-term effects on fetal development and susceptibility to disease in the newborn. For example low maternal folate is associated with neural tube defects, but also may have more variety of other effects on health programming in the offspring. The placenta may be a source of information about the health of the fetus/newborn. We are using genomic approaches to understand causes of birth defects and inflammatory conditions of the newborn and to use these to better predict newborn health at birth.

Placental complications of pregnancy
Every year in Canada, thousands of pregnancies experience obstetrical complications, including preeclampsia, low birth weight, and pre-term delivery. These conditions put the newborn baby at higher risk of adverse health consequences, the mosty immediate of which is an increased risk of early infection. To improve the health of babies and children we want to better understand the causes of such conditions and provide tools to improve early screening of pregnant women and newborn babies to identify those most at risk. We are currently investigating the role of genetic and epigenetic changes in such outcomes. In particular, we are utilizing genomic approaches to study global alterations in DNA methylation and gene expression, and to identify DNA and non-coding RNAs that can be exchanged between mother, placenta and fetus. This research will serve as an important step to improve diagnosis and identify potential treatments that may assist in the management of such pregnancies.

The genetics of sex differences related to perinatal health
Our goal is to understand why pregnancies with a female fetus are less vulnerable to infection, preterm birth and other adverse outcomes, than those with a male fetus. At the most basic level, the only difference between males and females is that males generally have one X and one Y chromosome, while females have two X chromosomes. In females, most of the genes on of the two X's in are typically turned off in each cell to equalize gene dosage between the sexes; However, this process appears to be relatively sloppy in the placenta, the organ upon which the fetus depends on for normal growth and development. We expect that sex-differences in placental biology likely drive a wide-range of downstream effects on fetal health including susceptibility to infection and preterm birth. Our goal is to understand the basis for these sex-differences in the placenta and how this might account for the increased risks to male fetuses. We also hope to bring attention to some of the fundamental biological differences between the sexes that influence how different early in utero exposures might affect infant development.

Honours & Awards

Medical Genetics Departmental Teaching Award 2005

Investigatorship, BC Research Institute for Children's & Women's Health – July 1994

Killam Teaching Award 2007

Research Group Members

Maria Peñaherrera, Research Associate I / Lab Manager
Chaini Konwar, Doctoral Student
Giulia Del Gobbo, Graduate Research Assistant
Ziqi Liu, Undergraduate Student
Irina Manokhina, Research Associate
Ishira Bharadwaj, Undergraduate Student
Victor Yuan, Graduate Student
Desmond Hui, Research Assistant/Technician 2
Ernesto Morales
Amy Inkster, Masters Student, Medical Genetics