Overview

My research focuses on the application of multi-modality functional neuroimaging methods, which link abnormalities of neurological function to demonstrable alterations of neuroanatomy and neurophysiology, and thereby enhance understanding of neurological disorders in infants, children and young adults with stroke and other brain injuries (e.g., sports concussions), epilepsy and neurodevelopmental disorders. I collaborate with regional, national and international collaborators who seek to evaluate outcomes and enhance neurological care using advanced non-invasive functional neuroimaging methodologies for children.

Publications

Alterations in Resting-State Networks Following In Utero Selective Serotonin Reuptake Inhibitor Exposure in the Neonatal Brain.
Biological psychiatry. Cognitive neuroscience and neuroimaging
Rotem-Kohavi N and Williams LJ and Virji-Babul N and Bjornson BH and Brain U and Werker JF and Grunau RE and Miller SP and Oberlander TF
DOI: 10.1016/j.bpsc.2018.08.004
PubMed: 30292808
08/2018

Socioeconomic determinants of outcome after childhood arterial ischemic stroke.
Neurology
Jordan LC and Hills NK and Fox CK and Ichord RN and Pergami P and deVeber GA and Fullerton HJ and Lo W and VIPS Investigators
DOI: 10.1212/wnl.0000000000005946
PubMed: 29980641
07/2018

Brain abnormalities in children and adolescents with chronic kidney disease.
Pediatric research
Matsuda-Abedini M and Fitzpatrick K and Harrell WR and Gipson DS and Hooper SR and Belger A and Poskitt K and Miller SP and Bjornson BH
DOI: 10.1038/s41390-018-0037-5
PubMed: 29967532
07/2018

Mortality after pediatric arterial ischemic stroke
Pediatrics
DOI: 10.1542/peds.2017-4146
2018

Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors
Pediatric Neurology
DOI: 10.1016/j.pediatrneurol.2017.09.019
2018

Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study.
AJNR. American journal of neuroradiology
Wintermark M and Hills NK and DeVeber GA and Barkovich AJ and Bernard TJ and Friedman NR and Mackay MT and Kirton A and Zhu G and Leiva-Salinas C and Hou Q and Fullerton HJ and VIPS Investigators
DOI: 10.3174/ajnr.A5376
PubMed: 28982784
10/2017

Advancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: protocol study.
BMJ open
DOI: 10.1136/bmjopen-2017-017012
PubMed: 28710227
07/2017

Diagnostic Yield And Treatment Impact Of Targeted Exome Sequencing In Early-Onset Epilepsy
Demos M and Guella I and McKenzie MB and Buerki SE and Evans DM and Toyota EB and Boelman C and Huh LL and Datta A and Michoulas A and Selby K and Bjornson BH and Horvath G and Farrer MJ
DOI: 10.1101/139329
05/2017

Harnessing Neuroimaging Capability in Pediatric Stroke: Proceedings of the Stroke Imaging Laboratory for Children Workshop
Pediatric Neurology
Nomazulu Dlamini and Max Wintermark and Heather Fullerton and Stephen Strother and Wayne Lee and Bruce Bjornson and Kristin P. Guilliams and Steven Miller and Adam Kirton and Christopher G. Filippi and Alexandra Linds and Rand Askalan and Gabrielle deVeber
DOI: 10.1016/j.pediatrneurol.2017.01.006
04/2017

Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry
Pediatr Neurol
DOI: doi: 10.1016/j.pediatrneurol.2017.01.016.
PubMed: 28254555
04/2017

Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry.
deVeber GA and Kirton A and Booth FA and Yager JY and Wirrell EC and Wood E and Shevell M and Surmava AM and McCusker P and Massicotte MP and MacGregor D and MacDonald EA and Meaney B and Levin S and Lemieux BG and Jardine L and Humphreys P and David M and Chan AK and Buckley DJ
DOI: 10.1016/j.pediatrneurol.2017.01.016
PubMed: 28254555
01/2017

Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence.
Fullerton HJ and deVeber GA and Hills NK and Dowling MM and Fox CK and Mackay MT and Kirton A and Yager JY and Bernard TJ and Hod EA and Wintermark M and Elkind MS and VIPS Investigators
DOI: 10.1161/strokeaha.116.013719
PubMed: 27491741
09/2016

Surface displacement based shape analysis of central brain structures in preterm-born children
Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
Amanmeet Garg and Ruth E. Grunau and Karteek Popuri and Steven Miller and Bruce Bjornson and Kenneth J. Poskitt and Mirza Faisal Beg
DOI: 10.1117/12.2216914
03/2016

Risk of Recurrent Arterial Ischemic Stroke in Childhood: A Prospective International Study.
Fullerton HJ and Wintermark M and Hills NK and Dowling MM and Tan M and Rafay MF and Elkind MS and Barkovich AJ and deVeber GA and VIPS Investigators
DOI: 10.1161/strokeaha.115.011173
PubMed: 26556824
01/2016

Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis?
Stroke
DOI: 10.1161/STROKEAHA.115.011331
2016

Further Validation of the SIGMAR1 c.151+1G>T Mutation as Cause of Distal Hereditary Motor Neuropathy.
Child neurology open
DOI: 10.1177/2329048x16669912
PubMed: 28503617
2016

Risk of Recurrent Arterial Ischemic Stroke in Childhood: A Prospective International Study.
DOI: 10.1161/STROKEAHA.115.011173
PubMed: 26556824
2016

Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence.
DOI: 10.1161/STROKEAHA.116.013719
PubMed: 27491741
2016

Infection, vaccination, and childhood arterial ischemic stroke: Results of the VIPS study.
Fullerton HJ and Hills NK and Elkind MS and Dowling MM and Wintermark M and Glaser CA and Tan M and Rivkin MJ and Titomanlio L and Barkovich AJ and deVeber GA and VIPS Investigators
DOI: 10.1212/wnl.0000000000002065
PubMed: 26423434
10/2015

Neonatal Pain and Infection Relate to Smaller Cerebellum in Very Preterm Children at School Age
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2015.04.055
2015

Infection, vaccination, and childhood arterial ischemic stroke: Results of the VIPS study.
DOI: 10.1212/WNL.0000000000002065
PubMed: 26423434
2015

Manually segmented template library for 8-year-old pediatric brain MRI data with 16 subcortical structures
J. Med. Imag
Amanmeet Garg and Darren Wong and Karteek Popuri and Kenneth J. Poskitt and Kevin Fitzpatrick and Bruce Bjornson and Ruth E. Grunau and Mirza Faisal Beg
DOI: 10.1117/1.jmi.1.3.034502
10/2014

Cerebellar language mapping and cerebral language dominance in pediatric epilepsy surgery patients
NeuroImage: Clinical
DOI: 10.1016/j.nicl.2014.06.016
2014

Manually segmented template library for 8-year-old pediatric brain MRI data with 16 subcortical structures
Journal of Medical Imaging
DOI: 10.1117/1.JMI.1.3.034502
2014

The effects of pediatric epilepsy on a language connectome
Human Brain Mapping
DOI: 10.1002/hbm.22600
2014

Invasive procedures in preterm children: Brain and cognitive development at school age
Pediatrics
DOI: 10.1542/peds.2013-1863
2014

Classification of FMRI patterns-A study of the language network segregation in pediatric localization related epilepsy
Human Brain Mapping
DOI: 10.1002/hbm.22265
2014

Arteriopathy diagnosis in childhood arterial ischemic stroke: Results of the vascular effects of infection in pediatric stroke study
Stroke
DOI: 10.1161/STROKEAHA.114.007404
2014

Antithrombotic therapy for secondary stroke prevention in bacterial meningitis in children
J Pediatr
DOI: 10.1016/j.jpeds.2014.06.013
2014

Neonatal Pain-Related Stress Predicts Cortical Thickness at Age 7 Years in Children Born Very Preterm
PLoS ONE
DOI: 10.1371/journal.pone.0076702
2013

Serial monitoring of CO2 reactivity following sport concussion using hypocapnia and hypercapnia
Brain Injury
DOI: 10.3109/02699052.2012.743185
2013

A decisional space for fMRI pattern separation using the principal component analysis-a comparative study of language networks in pediatric epilepsy
Human Brain Mapping
DOI: 10.1002/hbm.22069
2013

Cortical basis for dichotic pitch perception in developmental dyslexia
Brain and Language
DOI: 10.1016/j.bandl.2012.09.002
2012

Symptomatic neonatal arterial ischemic stroke: the International Pediatric Stroke Study.
Kirton A and Armstrong-Wells J and Chang T and Deveber G and Rivkin MJ and Hernandez M and Carpenter J and Yager JY and Lynch JK and Ferriero DM and International Pediatric Stroke Study Investigators
DOI: 10.1542/peds.2011-1148
PubMed: 22123886
12/2011

Cerebrovascular reactivity impairment after sport-induced concussion
Medicine and Science in Sports and Exercise
DOI: 10.1249/MSS.0b013e3182249539
2011

Sub-patterns of language network reorganization in pediatric localization related epilepsy: A multisite study
Human Brain Mapping
DOI: 10.1002/hbm.21066
2011

Cerebrovascular reactivity impairment after sport-induced concussion
Medicine & Science in Sports & Exercise
DOI: 10.1249/mss.0b013e3182249539
PubMed: 21606867
2011

Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study.
Jordan LC and Rafay MF and Smith SE and Askalan R and Zamel KM and deVeber G and Ashwal S and International Pediatric Stroke Study Group
DOI: 10.1016/j.jpeds.2009.11.061
PubMed: 20149389
05/2010

The role of area V5/MT+ in the centripetal bias in global motion perception
Journal of Vision
D. Giaschi and A. Zwicker and S. A. Young and B. Lee and B. Bjornson
DOI: 10.1167/7.9.751
03/2010

Combined Functional MRI and Diffusion Tensor Imaging Analysis of Visual Motion Pathways
Journal of Neuro-Ophthalmology
Linda J Lanyon and Deborah Giaschi and Simon Au Young and Kevin Fitzpatrick and Lu Diao and Bruce H Bjornson and Jason J S Barton
DOI: 10.1097/wno.0b013e3181a58ef8
06/2009

Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study.
Amlie-Lefond C and deVeber G and Chan AK and Benedict S and Bernard T and Carpenter J and Dowling MM and Fullerton H and Hovinga C and Kirton A and Lo W and Zamel K and Ichord R and International Pediatric Stroke Study
DOI: 10.1016/s1474-4422(09)70106-1
PubMed: 19423401
06/2009

Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study.
Golomb MR and Fullerton HJ and Nowak-Gottl U and Deveber G and International Pediatric Stroke Study Group
DOI: 10.1161/strokeaha.108.521203
PubMed: 18787197
01/2009

Intracranial calcification after cord blood neonatal transplantation for Krabbe disease
Neuropediatrics
DOI: 10.1055/s-0029-1243189
2009

Overlapping cortical systems for reading and temporal processing
CANADIAN JOURNAL OF EXPERIMENTAL PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE EXPERIMENTALE
2009

Combined functional MRI and diffusion tensor imaging analysis of visual motion pathways
Journal of Neuro-Ophthalmology
DOI: 10.1097/WNO.0b013e3181a58ef8
2009

Conscious visual abilities in a patient with early bilateral occipital damage
Developmental Medicine & Child Neurology
Deborah Giaschi and James E Jan and Bruce Bjornson and Simon Au and Matthew Tata MSc and Christopher J Lyons and Peter KH
DOI: 10.1111/j.1469-8749.2003.tb00888.x
02/2007

The role of cortical area V5/MT+ in speed-tuned directional anisotropies in global motion perception
Vision Research
DOI: 10.1016/j.visres.2006.12.017
2007

Anti-basal ganglia antibodies and acute movement disorder following herpes zoster and streptococcal infections
European Journal of Paediatric Neurology
DOI: 10.1016/j.ejpn.2006.11.001
2007

Asymmetrical cortical activation by global motion in children with dyslexia
Journal of Vision
D. Giaschi and V. Edwards and S. A. Young and B. Bjornson
DOI: 10.1167/5.8.848
09/2005

Genotypic heterogeneity and clinical phenotype in triple A syndrome: A review of the NIH experience 2000-2005
Clinical Genetics
DOI: 10.1111/j.1399-0004.2005.00482.x
2005

Psychophysical indexes of temporal processing abnormalities in children with developmental dyslexia
Developmental Neuropsychology
DOI: 10.1207/s15326942dn2503_5
2004

Conscious visual abilities in a patient with early bilateral occipital damage.
Giaschi D and Jan JE and Bjornson B and Young SA and Tata M and Lyons CJ and Good WV and Wong PK
DOI: 10.1017/s0012162203001439
PubMed: 14580134
11/2003

Simultaneous registration and activation detection for fMRI
IEEE Transactions on Medical Imaging
DOI: 10.1109/TMI.2003.819294
2003

Overcoming activation-induced registration errors in fMRI
Proceedings of SPIE - The International Society for Optical Engineering
DOI: 10.1117/12.480849
2003

Conscious visual abilities in a patient with early bilateral occipital damage
Journal of Vision
DOI: 10.1167/2.7.428
2002

Cerebral Sinovenous Thrombosis in Children
N Engl J Med
Gabrielle deVeber and Maureen Andrew and Coleen Adams and Bruce Bjornson and Frances Booth and David J. Buckley and Carol S. Camfield and Michèle David and Peter Humphreys and Pierre Langevin and E. Athen MacDonald and Brandon Meaney and Michael Shevell and D. Barry Sinclair and Jerome Yager and Jane Gillett
DOI: 10.1056/nejm200108093450604
08/2001

Cerebral sinovenous thrombosis in children
New England Journal of Medicine
DOI: 10.1056/NEJM200108093450604
2001

Hemispheric dissociation of verb generation from verb reading: functional MRI of an adolescent with early left MCA infraction
NEUROIMAGE
2001

Hemispheric dissociation of verb generation from verb reading: functional MRI of an adolescent with early left MCA infraction
NEUROIMAGE
2001

High resolution EEG & seizure localization
NeuroImage
1999

Non-invasive mapping of sensorimotor cortex in a child with a cavernous angioma: FMRI and high-resolution EEG compared with surgical mapping
NeuroImage
1999

High resolution EEG & seizure localization
NeuroImage
1999

Non-invasive mapping of sensorimotor cortex in a child with a cavernous angioma: FMRI and high-resolution EEG compared with surgical mapping
NeuroImage
1999

Dichotic pitch
NeuroReport
Robert F. Dougherty and Max S. Cynader and Bruce H. Bjornson and Dorothy Edgell and Deborah E. Giaschi
DOI: 10.1097/00001756-199809140-00015
09/1998

Comparison of visual activation measured by fMRI and high resolution EEG
NeuroImage
1998

Comparison of visual activation measured by fMRI and high resolution EEG
NeuroImage
1998

Dichotic pitch: A new stimulus distinguishes normal and dyslexic auditory function
NeuroReport
1998

Basal ganglia infarction associated with HHV-6 infection
Archives of Disease in Childhood
D. W Webb and B. H Bjornson and M. A Sargent and J. Hukin and E. E Thomas
DOI: 10.1136/adc.76.4.362
04/1997

In search of the best psychophysical indicator of an M-stream deficit in developmental dyslexia
Investigative Ophthalmology and Visual Science
1997

In search of the best psychophysical indicator of an M-stream deficit in developmental dyslexia
Investigative Ophthalmology and Visual Science
1997

Basal ganglia infarction associated with HHV-6 infection
Archives of Disease in Childhood
PubMed: 9166034
1997

Basal ganglia infarction associated with HHV-6 infection
Archives of Disease in Childhood
1997

Ictal and interictal technetium-99m-bicisate brain SPECT in children with refractory epilepsy.
Packard AB and Roach PJ and Davis RT and Carmant L and Davis R and Riviello J and Holmes G and Barnes PD and O'Tuama LA and Bjornson B and Treves ST
PubMed: 8965177
07/1996

Ictal and interictal technetium-99m-bicisate brain SPECT in children with refractory epilepsy
Journal of Nuclear Medicine
1996

Ictal and interictal technetium-99m-bicisate brain SPECT in children with refractory epilepsy
Journal of Nuclear Medicine
PubMed: 8965177
1996

Brain
Pediatric Nuclear Medicine
L. A. O’Tuama and B. Bjornson and H. Chugani and S. T. Treves
DOI: 10.1007/978-1-4757-4205-3_6
1995

Computed Tomography Imaging in Children with Head Trauma: Utilization and Appropriateness from a Quality Improvement Perspective
Infection Control and Hospital Epidemiology
Montserrat Vera and Gary R. Fleisher and Patrick D. Barnes and Bruce H. Bjornson and Elizabeth N. Allred and Donald A. Goldmann
DOI: 10.2307/30145525
08/1993

computed tomography imaging in children with head trauma: Utilization and appropriateness from a quality improvement perspective
Infection Control & Hospital Epidemiology
DOI: 10.1086/646787
1993

Regional cerebral perfusion in Landau-Kleffner syndrome and related childhood aphasias.
O'Tuama LA and Urion DK and Janicek MJ and Treves ST and Bjornson B and Moriarty JM
PubMed: 1383478
10/1992

Regional cerebral perfusion in Landau-Kleffner syndrome and related childhood aphasias
Journal of Nuclear Medicine
1992

Regional cerebral perfusion in Landau-Kleffner syndrome and related childhood aphasias
Journal of Nuclear Medicine
PubMed: 1383478
1992

Research

IPSS Study - International Paediatric Stroke Study
We aim to obtain preliminary data from large multi-center studies assessing sub-types, outcomes and current treatments for newborns and children with stroke. Due to the relative rarity of childhood stoke, sufficient numbers of patients to provide the necessary power can only be achieved with multi-center and multi-national approaches. The overall objective is to develop and conduct clinical trials in childhood stroke.

The specific aims are:

Ascertain in a prospective cohort study, the numbers of newborns and children with ischemic stroke, their stroke sub-types and risk factors, their current treatments and outcomes within the participating centers. These data will provide the rationale and feasibility data for the study group to design and implement the initial RCT’s in paediatric stroke as well as other fundable grant proposals.

Develop and institute standardized protocols for (1) diagnosis, (2) investigation of risk factors, (3) antithrombotic therapies and (4) outcome assessment of neonates and children with arterial ischemic stroke and sinovenous thrombosis

Develop standardized data forms and an appropriate database with web-based data entry from multiple study sites.

Submit successful grant applications for additional funding of IPSS multi-centre studies.
This prospective study enrolls newborns and children with ischemic stroke born at or referred to BC Children’s Hospital. These newborns are then followed at 3 and 12 months post stroke.

fMRI Study - Multi-Site Pediatric Network for fMRI Mapping in Childhood Epilepsy
We aim to establish the utility of functional Magnetic Resonance Imaging (fMRI) in identifying atypical language in childhood localization related epilepsy, by using a variety of language paradigms that have already been tested in normal children and patients with epilepsy.

The study objectives include:

To establish the network infrastructure for multi-site collection and management of functional imaging data linked to a database of common assessments and measures

To establish the feasibility of conducting multi-site fMRI by identifying patients with atypical language, and to provide pilot data necessary to conduct a large scale study to compare fMRI findings to invasive methods (IAT, ECS, surgical outcome)

To achieve this goals, an imaging consortium with web based access and central data storage will be established. A multi-centre, cross sectional prospective study will use fMRI to study patients undergoing epilepsy surgery. Clinical data will be collected as part of routine evaluation for chronic epilepsy in children considered for epilepsy surgery.

Honours & Awards

Farley Fellowship (Children's Hospital, Boston), 1992

University of Alberta Alumni Association Award , 1977

Adella Patridge Award for Cardiology (University of Alberta), 1981

Von Meyer Travelling Award (Children's Hospital, Boston), 1991

Research Group Members

Salah Almubarak, MEG Consultant:Division Head, Pediatric Neurology, University of Saskatchewan
Justin Dragoman
Lilah Johnson, Research Asst/Tech 3
Daniel Kim, Neuroinformatics Engineer, Neuro Informatics Engineer
Ghoufran Talib, Research Assistant
Jessica Wang, Medical Student FLEX
Lynne Williams, Staff Scientist, Technology Integration Manager
Betty Wong, Admin. Assistant, Pediatric ICU