• Woodward, Todd

    Titles

    Investigator, BC Children's Hospital

    Professor, Department of Psychiatry, Faculty of Medicine, University of British Columbia

    Degrees / Designations

    B.Sc., MA, Ph.D.

    Primary Area of Research
    Brain, Behaviour & Development
    Secondary Area(s) of Research
    Phone
    604-875-2000 ext. 4724
    Fax
    Lab Phone
    Mailing Address

    BC Children's Hospital Research Institute
    Room 116, 3rd Floor
    938 W. 28th Avenue
    Vancouver, V5Z 4H4

    Affiliate Websites

    Profiles:

    Research Areas

    • Schizophrenia
    • Functional neuroimaging
    • Cognitive psychology
    • Cognitive Neuropsychology
    • Delusions
    • Hallucinations
    • Memory
    • Reasoning
    Summary

    Dr. Woodward is a Professor within the Department of Psychiatry in the Faculty of  Medicine, a Research Scientist with the BC Mental Health and Addictions Research Institute (BCMHARI), and Centre Investigator with the Brain Research Centre.

    The objective of Dr. Woodward’s research program is to gain a functional and anatomical understanding of the functional brain networks that underlie the primary symptoms of psychosis and schizophrenia. Three lines of research are being pursued.

    First, the cognitive correlates of the symptoms of psychosis are being explored by way of originally designed cognitive paradigms assessing specific aspects of memory and reasoning. Translation of these results back to people with schizophrenia in a group setting have led to a promising treatment program called metacognitive training (MCT). Second, functional neuroimaging (fMRI, EEG, MEG) is being utilized to identify the neural underpinnings of these cognitive functions, and how their dysfunction manifests as the symptoms of psychosis, and how they are affected by MCT. Finally, software is being developed for multivariate analysis of functional neuroimaging data (fMRI-CPCA and MEG-CPCA).

    Current Projects

    Functional Neuroimaging

    The objectives of our functional neuroimaging research are (1) to gain a functional and anatomical understanding of the cognitive systems involved in psychosis and schizophrenia, and (2) to develop new multivariate methods for analyzing fMRI data, with applications to integrating information from fMRI, EEG and MEG..

    Cognitive Neuropsychiatry 

    The objective of our cognitive neuropsychiatry research is to identify the cognitive operations underlying the primary symptoms of psychosis and schizophrenia. This is being explored by way of originally designed cognitive paradigms for memory confidence, source monitoring, reasoning, and semantic association.

    Selected Publications
    • Curčić-Blake, B., Ford, J., Hubl, D., Orlov, N., Sommer, I., Waters, F., Allen, P., Jardri, R., Woodruff, P. W., Olivier, D., Mulert, C., Woodward, T. S., & Aleman, A. (2016). Interaction of language, auditory and memory brain networks in auditory verbal hallucinations. Progress in Neurobiology. PMID: 27890810
    • Lavigne, K., Menon, M. & Woodward, T. S. (2016). Impairment in subcortical suppression in schizophrenia: Evidence from the fBIRN oddball task. Human Brain Mapping, 37, 4640-4653. PMID: 27477494
    • Whitman, J. C., Takane, Y., Cheung, T., Moiseev, A., Ribary, U., Ward, L. M., & Woodward, T. S. (2016). Acceptance of evidence-supported hypotheses generates a stronger signal from an underlying functionally-connected network. NeuroImage, 127, 215-226. PMID: 2670277
    • Woodward, T. S., Leong, K, Sanford, N. Tipper, C. M. & Lavigne, K. M., & (2016). Altered balance of functional brain networks in schizophrenia. Psychiatry Research: NeuroImaging. 248, 94-104. PMID: 26786152
    • Moritz, S., Woodward, T. S., & Balzan, R. (2016). Is metacognitive training for Psychosis effective? Expert Review of Neurotherapeutics, 16(2), 105-7. PMID: 26694013
    • Lavigne, K. M., Rapin, L. A., Metzak, P. D., Whitman, J. C., Jung, K. & Dohen, M., Lœvenbruck, H. & Woodward, T. S. (2015). Left-dominant temporal-frontal hypercoupling in schizophrenia patients with hallucinations during speech perception. Schizophrenia Bulletin, 41(1): 259-267. PMID: 24553150
    • Moritz, S., Veckenstedt, R., Bohn, F., Hottenrott, B., Andreou, C., Leighton, L., Köther, U., Woodward, T. S., Treszl, A., Menon, M., Viertel, B., Pfueller, U., & Roesch-Ely, D. (2014).  Sustained and “sleeper” effects of group metacognitive training for schizophrenia: A randomized clinical trial. JAMA: Psychiatry, 71(10), 1103-1111. PMID: 25103718
    • Woodward, T. S., Jung, K., Hwang, H., Yin, J., Taylor, L., Menon, M., Peters, E., Kuipers, E., Waters, F., Lecomte, T., Sommer, I., Daalman, K., van Lutterveld, R., Hubl, D., Kindler, J., Homan, P., Badcock, J. C., Chhabra, S., Cella, M., Keedy, S., Allen, P., Mechelli, A., Preti, A., Siddi, S. & Erickson, D. (2014). Symptom dimensions of the Psychotic Symptom Rating Scales in psychosis: A multi-site study. Schizophrenia Bulletin, 40(S4), S265–S274. PMID: 24936086
    • Woodward, T. S., Jung, K., Smith, G., Hwang, H., Barr, A. M.,  Procyshyn, R. M., Flynn, S., van der Gaag, M., & Honer, W. G. (2014). Symptom Changes in Five Dimensions of the Positive and Negative Syndrome Scales in Refractory Psychosis. European Archives of Psychiatry and Clinical Neuroscience, 264, 673-682. PMID: 24126470
    • Sanford, N., Veckenstedt,R., Moritz, S., Balzan, R., & Woodward, T. S. (2014). Impaired Integration of Disambiguating Evidence in Delusional Schizophrenia Patients. Psychological Medicine, 44(13), 2729-2738. PMID: 25065271
    • Moritz, S., Veckenstedt, R., Bohn, F., Hottenrott, B., Scheu, F., Randjbar, S., Aghotor, J., Köther, U., Woodward, T. S., Treszl, A., Andreou, C., Pfueller, U., & Roesch-Ely, D. (2013). Complementary Group Metacognitive Training (MCT) reduces delusional ideation in schizophrenia. Schizophrenia Research, 151, 61-69. PMID: 24183707
    • Ranger, M., Chau, C. M., Garg, A., Woodward, T. S., Beg, M. F, Bjornson, B., Poskitt, K., Fitzpatrick, K., Synnes, A. R., Miller, S. P., Grunau, R. E. (2013). Neonatal pain-related stress predicts cortical thickness at age 7 years in children born very preterm. PLOS ONE, 8(10), e76702. PMID: 24204657
    • Sanford, N., Woodward, T. S., Lecomte, T., Leclerc, C. & Wykes, T. (2013). Change in jumping to conclusions linked to change in delusions in early psychosis. Schizophrenia Research, 147, 207-208. PMID: 23561297
    • Whitman, J. C., Metzak, P. D., Lavigne, K. & Woodward, T. S. (2013). Functional connectivity in a frontoparietal network involving the dorsal anterior cingulate cortex underlies decisions to accept a hypothesis. Neuropsychologia, 51(6), 1132-1141. PMID: 23474076
    • Woodward, T. S., Feredoes, E., Metzak, P. D., Takane, Y. & Manoach, D. S. (2013). Epoch-specific functional networks involved in working memory. Neuroimage, 65: 529-539. PMID: 23041527
    Grants
    • Canadian Institutes of Health Research (CIHR) Operating Grant (2013-18). $617,395. Project Title: Functional Brain Networks Underlying Non-pharmaceutical Interventions for Psychosis. T. S. Woodward (PI), M. Menon & S. Moritz.

    • Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (2012-17). $160,000. Project Title: Multimodal Neuroimaging of Cognitive Control. T. S. Woodward (PI).

    • Martha Piper Research Fund (2011-2013). $25,000. Project Title: The Functional Connectome: Hallucinations. T. S. Woodward (PI), R. Abugharbieh, P. Allen, A. Aleman, J. Ford &  I. Sommer.

    • Mind Foundation of BC Young Investigator Award (2011-2013). $100,000. Project Title: Multimodal Functional Neuroimaging of the Networks underlying Cognitive Impairment in Schizophrenia. T. S. Woodward (PI).

    • Social Sciences and Humanities Research Council (SSHRC) Operating Grant (2011-14). $86,050. Project Title: Determinants of individual differences in formation and revision of beliefs. T. S. Woodward (PI) & A. Ryder.

    • Social Sciences and Humanities Research Council (SSHRC) Operating Grant (2010-11). $52,745. Project Title: Determinants of individual differences in formation and revision of beliefs. T. S. Woodward (PI) & A. Ryder.

    • Down Syndrome Research Foundation (DSRF) Time Grant (2010-11). $12,000. Project Title: Neural Networks involved in Optimization of Generalized Cognitive Performance. T. S. Woodward (PI) & P. D. Metzak.

    • Canadian Institutes of Health Research (CIHR) Operating Grant (2009-12). $298,432. Project Title: Integration of Disconfirmatory Evidence in Schizophrenia: Cognitive and Neural Underpinnings. T. S. Woodward (PI), S. Moritz, E. T. C. Ngan & W. Honer.

    • BC Mental Health and Addictions Services (BCMHAS) Seed Grant. (2009-10). $7,500. Project Title: Cognitive dysfunctions associated with brain changes caused by a mutation in the NSDHL gene. T. S. Woodward (PI), C. F. Boerkoel, & C. Du Souich.

    • Canadian Institutes of Health Research (CIHR) Operating Grant (2008-12). $219,768. Project Title: Physiological and behavioral evidence of conflict modulation failure in dual stream information processing in delusional schizophrenic patients. E. T. C. Ngan (PI) & T. S. Woodward (Co-I).

    • Canadian Institutes of Health Research (CIHR) Operating Grant (2008-09). $100,000. Project Title: Integration of Disconfirmatory Evidence in Schizophrenia: Cognitive and Neural Underpinnings. T. S. Woodward (PI), S. Moritz, E. T. C. Ngan & W. Honer.

    • NARSAD Young Investigator Award (2008-10). $60,000 Operating Grant. Project Title: Dysconnectivity of Hippocampo-Prefrontal Neural Systems in Schizophrenia. T. S. Woodward (PI).

    • Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (2007-12). $152,735. Project Title: The role of medial-prefrontal neural systems in cognitive flexibility. T. S. Woodward (PI).

    • Canadian Institutes of Health Research (CIHR) Operating Grant (2007-10). $243,918. Project Title: Traitement des symptômes psychotiques chez des jeunes présentant un premier épisode de schizophrénie - effets de la thérapie cognitive comportementale de groupe. T. Lecomte, C. R. Leclerc, A. Spidel, T.S. Woodward (Co-I) & T. Wykes.

    • Canadian Institutes of Health Research (CIHR) Operating Grant (2006-11). $367,935. Project Title: The contextual effects of trial history on saccades, and their status in neurologic disorders. J. J. Barton, D. S. Manoach, & T. S. Woodward (Co-I).

    Honours & Awards
    • Brain & Behaviour Research Foundation Independent Investigator Award (2016)
    • Peter Wall Institute for Advanced Studies Early Career Award (2013)
    • The Dr. Samarthji Lal award for Mental Health Research (2012) Wall Institute Start-Up Research Award (2012)
    • Confederation of University Faculty Associations of British Columbia (CUFA BC) Distinguished Academics Award: Early in Career Award-Sponsored by Scotiabank (2010) Distinguished Achievement Awards of the Faculty of Medicine: Excellence in Clinical or Applied Research (2009)
    • Canadian Institutes of Health Research (CIHR) New Investigator Michael Smith Prize for Research in Schizophrenia (2008)
    • Canadian College of Neuropsychopharmacology (CCNP) Young Investigator Award (2008) Canadian Institutes of Health Research (CIHR) New Investigator Award (2008-2013; 5 year salary award)
    • NARSAD: The Mental Health Research Association Young Investigator Award (2008-2010) Michael Smith Foundation for Health Research (MSFHR) Career Award: Scholar (2006-2012; 6 year salary award)
    • NARSAD: The Mental Health Research Association Young Investigator Award (2006).
    Research Group Members
    • PhD: Katie Lavigne, Nicole Sanford, Meighen Roes

    • Graduate Student: Jessica Luk 

    • Research Coordinator: Julia Iman O'Loughlin