• Vilte Barakauskas

    Barakauskas, Vilte

    Investigator, BC Children's Hospital
    Clinical Assistant Professor, Pathology & Laboratory Medicine Clinical Biochemist, Pathology & Laboratory Medicine, Division of Clinical Biochemistry
    Degrees / Designations


    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    604-875-2345 ext. 7649
    Lab Phone
    Michelle Dittrick
    Assistant Phone
    604-875-2345 ext. 4679
    Mailing Address
    BC Children's Hospital
    Room 2J9
    4480 Oak Street
    Vancouver, BC V6H 3V4

    Research Areas
    • Clinical biochemistry
    • Laboratory testing
    • Diagnostic methods
    • Quality improvement
    • Laboratory utilization

    I am interested in how the clinical laboratory impacts pediatric and perinatal healthcare and outcomes. My research interests span areas of laboratory medicine that impact test use, interpretation and quality, including laboratory quality improvement; optimizing laboratory test utilization; improving test interpretation; and developing, improving and characterizing laboratory testing methods.

    Current Projects
    I am interested in laboratory quality improvement, optimization of test utilization and interpretation, as well as clinical laboratory method development and validation for application to pediatric and maternity care.

    I am currently working to characterize the performance of analytical methods available at C&W for body fluid testing. In a hospital setting, body fluid testing (for example, pleural and peritoneal fluids or CSF) can aid in diagnosis and patient management. 

    I am also working towards improving laboratory test interpretation during pregnancy. Currently, results of laboratory tests for pregnant  women are compared to reference intervals for non-pregnant females. Significant physiological changes occur during pregnancy which can change blood chemistry parameters. While these changes are a normal part of pregnancy, they may be wrongly interpretted and result in inappropriate treatment or follow-up. This may adversely impact both mothers and babies, as well as impacting the health care system. Appropriate reference ranges for women during pregnancy are required to make appropriate clinical care decisions. My aim is to inform, update and produce pregnancy-specific reference intervals, which will improve maternal health care in Canada. 

    Selected Publications

    Gill J, Barakauskas VE, Thomas D, Rodriguez-Capote K, Higgins T, Zhang D, VanSpronsen A, Babenko O, Martindale R, Estey MP. "Evaluation of thyroid test utilization through analysis of population-level data."  Clin Chem Lab Med. 2017 Apr 04. PMID: 28306523

    Walker BS, Barakauskas V, Grenache DG, Schmidt RL. The Effect of Preanalytical Factors on the Stability of Maternal Serum Biomarkers and Calculated Risk for Trisomy 21, Trisomy 18, and Open Neural Tube Defect. Accepted for publication December 2016. ID# JALM/2016/022400

    Barakauskas VE, Bradshaw TA, Smith LD, Lehman CM, Johnson-Davis KL. Process Optimization to Improve Immunosuppressant Drug Testing Turnaround Time. Am J Clin Pathol. 2016 Aug;146(2):182-90.

    Barakauskas VE, Moradian A, Barr AM, Beasley CL, Rosoklija G, Mann JJ, Ilievski B, Stankov A, Dwork AJ, Falkai P, Morin GB, Honer WG. Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia. Schizophr Res. 2016 Nov;177(1-3):44-51

    Turley E, Rodríguez-Capote K, Estey MP, Barakauskas VE, Bailey GR, McKenzie LM, Higgins TN. Erroneous diabetes diagnosis: a case of HbA1c interference. Diabetes Care. 2015 Oct;38(10):e154-5.

    Rodríguez-Capote K, Estey MP, Barakauskas VE, Burton T, Holmes D, Krause R, Higgins TN. Identification of Hb Wayne and its effects on HbA1c measurement by 5 methods. Clin Biochem. 2015 Nov;48(16-17):1144-50.

    Rodríguez-Capote K, Estey MP, Barakauskas V, Bordeleau P, Christensen CL, Zuberbuhler P, Higgins TN.  A novel double heterozygous Hb Fontainebleau/HbD Punjab hemoglobinopathy. Clin Biochem. 2015 Sep;48(13-14):904-7.

    Andreazza AC, Barakauskas VE, Fazeli S, Feresten A, Shao L, Wei V, Wu CH, Barr AM, Beasley CL. Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum. Neurosci Lett. 2015 Mar 30;591:36-40.

    Estey MP, Capote KR, Barakauskas VE, Clarke G, Higgins T. Hemoglobin C in a patient with sickle cell anemia: transfusion-acquired SC disease. Clin Biochem. 2015 Apr;48(6):463-4.

    Barakauskas VE, Lam GY, Estey MP. Digesting all the options: laboratory testing for celiac disease. Crit Rev Clin Lab Sci. 2014 Dec;51(6):358-78.

    Barakauskas VE, Davis R, Krasowski MD, McMillin GA. Unresolved discrepancies between cannabinoid test results for infant urine. Clin Chem. 2012 Sep;58(9):1364-7.
    Honours & Awards

    2017 Mass Spectrometery in the Clinical Laboratory (MASCL) Meeting Travel Grant

    2012 American Association for Clinical Chemistry (AACC), Society for Young Clinical Laboratorians (SYCL) 2012 Domestic Travel Grant

    2011 AACC, Rocky Mountain Section [Travel & Meeting] Scholarship

    2011 University of Utah, Department of Pathology Research Support Funds

    2010 CIHR-INMHA Brain Star Award, September competition

    2008-2010 Michael Smith Foundation for Health Research (MSFHR) Senior Trainee Award

    2008 British Columbia Proteomics Network training allowance

    2006-2008 National Sciences and Engineering Council of Canada (NSERC), Canada Graduate Scholarship – Doctoral CGSD

    2006-2008 Michael Smith Foundation for Health Research (MSFHR) Junior Trainee Award

    2007 Michael W. Stahl Memorial Graduate Scholarship – University of British Columbia

    2006 Young Scientist [Travel] Award – 13th Biennial Winter Workshop on Schizophrenia Research

    2004-2006 National Sciences and Engineering Council of Canada (NSERC) Postgraduate Scholarship – Master’s PGSM

    2004-2005 CIHR/MSFHR Strategic Training Program in Neurobiology, UBC

    Research Group Members