• Honer, William

    • Investigator, BC Children's Hospital
    • Jack Bell Chair in Schizophrenia, Professor and Head, Department of Psychiatry Faculty of Medicine, University of British Columbia
    • Director, Institute of Mental Health, University of British Columbia
    Degrees / Designations
    Primary Area of Research
    Brain, Behaviour & Development
    Secondary Area(s) of Research
    Lab Phone
    Mailing Address
    Department of Psychiatry Unit 2C1
    2255 Wesbrook Mall

    Vancouver, BC V6T 2A1

    Affiliate Websites
    Research Areas

    Alzheimer's disease, Dementia/Neurodegenerative disorders, Psychotic disorders, Schizophrenia, Animal models, Biological mechanisms, Brain imaging, Clinical trials, Genetics, Human development, Neuropsychiatry/ Neuropsychology


    I am interested in translational research with the goals of linking understanding of the mechanisms of serious mental illness to new approaches to treating patients. Current projects focus on abnormalities of synapses in schizophrenia and aging, studies of response to antipsychotic drug treatment in patients, and investigating the overlap of mental illness, addiction, and viral infection in people living in single room occupancy hotels. I am also pursuing the development of novel treatments through investigating protein-protein interactions occurring at synapses. Research techniques used include biochemical studies of postmortem brain tissue, brain imaging with MRI, and neurocognitive assessment.

    Current Projects
    Selected Publications

    Vila-Rodriguez, F., Honer, W. G., Innis, S. M., Wellington, C. L., & Beasley, C. L. (2011). ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype. Journal of Psychiatry & Neuroscience : JPN, 36(1), 47-55. PMID: 20964956

    Torres, I. J., DeFreitas, V. G., DeFreitas, C. M., Kauer-Sant'Anna, M., Bond, D. J., Honer, W. G., Lam, R.W., & Yatham, L. N. (2010). Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. The
    Journal of Clinical Psychiatry, 71(9), 1234-1242. PMID: 20361907

    Smith, G.N., MacEwan, G.W., Kopala, Lang, D.J., Barr, A.M., Honer, W.G., Ehmann, T.S., Good, K., Thornton, A.E., & Neilson, H. (2010) Prenatal tobacco exposure in first-episode psychosis. 
    Schizophrenia Research, 119(1-3), 271–272. PMID: 20116216

    Procyshyn, R. M., Honer, W. G., Wu, T. K., Ko, R. W., McIsaac, S. A., Young, A. H., Johnson, J.L., & Barr, A. M. (2010). Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: A review of medication profiles in 435 canadian outpatients. 
    The Journal of Clinical Psychiatry, 71(5), 566-573. PMID: 20361903

    Procyshyn, R. M., Barr, A. M., Flynn, S., Schenk, C., Ganesan, S., & Honer, W. G. (2010). Long-acting injectable risperidone in treatment refractory patients: A 14-week open-label pilot study. 
    Schizophrenia Research, 123(2-3), 273-275. PMID: 20688481

    Procyshyn, R. M., Barr, A. M., Brickell, T., & Honer, W. G. (2010). Medication errors in psychiatry: A comprehensive review. 
    CNS Drugs, 24(7), 595-609. PMID: 20356315

    Pajonk, F. G., Wobrock, T., Gruber, O., Scherk, H., Berner, D., Kaizl, I., Kierer, A., Müller, S., Oest, M., Meyer, T., Backens, M., Schneider-Axmann, T., Thornton, A.E., Honer, W.G., & Falkai, P. (2010). Hippocampal plasticity in response to exercise in schizophrenia. 
    Archives of General Psychiatry, 67(2), 133-143. PMID: 20124113

    Hunter, M. J., Hippman, C., Honer, W. G., & Austin, J. C. (2010). Genetic counseling for schizophrenia: A review of referrals to a provincial medical genetics program from 1968 to 2007. 
    American Journal of Medical Genetics.Part A, 152A(1), 147-152. PMID: 20034078

    Chen, E. Y., Hui, C. L., Lam, M. M., Chiu, C. P., Law, C. W., Chung, D. W., Tso, S., Pang, E.P., Chan, K.T., Wong, Y.C., Mo, F.Y., Chan, K.P., Yao, T.J., Hung, S.F., & Honer, W. G. (2010). Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: Randomised controlled trial. 
    BMJ (Clinical Research Ed.), 341, c4024. PMID: 20724402

    Boyda, H. N., Tse, L., Procyshyn, R. M., Honer, W. G., & Barr, A. M. (2010). Preclinical models of antipsychotic drug-induced metabolic side effects. 
    Trends in Pharmacological Sciences, 31(10), 484-497. PMID: 20674990

    Honours & Awards
    Research Group Members