• Davis, Jeffrey

    Titles

    Investigator, BC Children's Hospital
    Clinical Associate Professor, Division of Hematology and Oncology, Department of Pediatrics, University of British Columbia

    Degrees / Designations
    B.Eng., MD
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2316
    Fax
    604-875-2911
    Lab Phone
    Mailing Address

    BC Children's Hospital and BC Women's Hospital & Health Centre
    Division of Oncology/Hematology/BMT
    Room A123C
    4480 Oak Street
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Clinical hematopoietic stem cell transplantation
    • Clinical pediatric oncology
    • Hemophilia
    Summary

    As site Principle Investigator for the Centre for International Bone Marrow Transplant Research (CIBMTR) group, my interests are focused on co-operative, inter-disciplinary programmes aimed at tackling the varied challenges presented by pediatric oncology and hematology patients.

    My background in engineering and current experience as a U.S. Naval Flight Surgeon underlines my interest in human factor analysis and risk management within the practice of medicine.  In an effort to reduce risk in health management to its lowest possible level, the naval aviation community's use of the "best practice" process to effectively identify, analyze and eliminate or help control a hazard can successfully be applied to our daily endeavors in medicine and will provide insight and options to our practices.

    Current Projects

    Demonstration of human safety & physician acceptance of a unique spinal injection safety system (SISS)
    The inadvertent administration of the wrong drug, by the spinal or epidural route, often with catastrophic results, continues to occur in medical practice. Several Canadian and world reports have demonstrated the tragic consequences in all medical fields utilizing spinal therapies, including oncology, anaesthesiology, and obstetrics.  Specific recent cases of death as a result of the maladministration of vinca alkaloids into the spine have been reported widely.  We have redesigned the spinal needle and system around intrathecal administration of medications and in this study we propose to implement the spinal injection safety system (SISS) in clinical practice.  Through evaluating the SISS we will determine its safety attributes for pediatric patients receiving spinal chemotherapy and whether or not it meets the practice expectations of physicians.  We also seek to significantly reduce the net risk of patient harm through inadvertent human error during the spinal drug administration procedure as well as be cost-effective in comparison to current practices.

    A study of hematopoietic stem cell transplantation (HSCT) in non-malignant disease using a reduced-intensity preparatory regime with campath-H, fludarabine and malphalan
    It is hoped that this study will provide evidence that a preparative regimen consisting of a combination of campath-H, fludarabine and malphalan will maximize host immunosuppression without myeloablation, while being well tolerated and sufficient for engraftment of donor hemopoietic cells when minimally mismatched from the recipient or acquired from unrelated sources.  It is postulated that this combination will allow for the gradual transition from recipient chimerism to full donor chimerism with minimal early and delayed toxicity to the recipient. The target is children with non-malignant diseases who are benefited by transplantation and for whom myeloablation is not necessary.

    Selected Publications

    Cuvelier GDE, Davis JH, Purves EC, Wu JK.  Torticollis as a sign of cervico-thoracic epidural hematome in an infant with severe haemophilia A.  Haemophilia. 2006; 12:683-686.

    Cohen L, Hirschfeld AF, Junker AK, Davis J, Turvey SE.  Detection of a novel nonsense mutation in the interleukin 2 receptor gamma gene causing X-linked severe combined immunodeficiency.  Ann Allergy Asthma Immunol. 2006 Apr; 96(4):632.

    Sheppard I, Davis J, Blackstock D.  Improving patient safety by design-a new spinal/intrathecal safety system.  Can J Anaesth. 2006 Jan; 53(1):108-109.

    Ly H, Schertzer M, Jastaniah W, Davis, J, Yong SL, Ouyang Q, Blackburn EH, Parslow TG, Lansdorp PM.  Identification and functional characterization of two variant alleles of telomerase RNA template gene (TERC) in a patient with Dyskeratosis Congenita.  Blood. 2005 Aug 15; 106(4):1246-52.

    Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, Hogge DE. Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis.  Bone Marrow Transplant. 2003 Nov; 32(9):915-23.

    McCahon E, Sorensen PHB, Davis JH, Rogers PCJ, Schultz KR.  Non-Resectable Congenital Tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy.  Medical Pediatric Oncology. 2003; 40:288-292.

    Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, Hogge DE.  Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis.  Bone Marrow Transplant. 2003 Nov;32(9):915-23.

    Cimolai N, Davis J, Trombley C. Candida dubliniensis fungemia and vascular access infection.  J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):237-9.

    Meyers PA, Krailo MD, Ladanyi M, Chan KW, Sailer SL, Dickman PS, Baker DL, Davis JH, et al.  High-Dose Melphalan, Etoposide, Total Body Irradiation, and Autologous Stem-Cell Reconstitution as Consolidation Therapy for High-Risk Ewing's Sarcoma Does Not Improve Prognosis.  Journal of Clinical Oncology. 2001 Jun:19(11).

    Grants
    Honours & Awards

    Bruce W Jackson Memorial Award for the Reserve Flight Surgeon of the Year, The Society of United States Naval Flight Surgeons - 2014
    Rookie of the Year Attending Award, University of British Columbia Residents - 1992
    Clinical Fellowship Award, American Cancer Society - 1987-1988
    Magna Cum Laude, Vanderbilt University - 1978
    Tau Beta Pi, National Engineering Honorary - 1976

    Research Group Members
    • Analyne Perez - Oncology Clinic RN
    • Nita Takeuchi - Senior Clinical Research Associate
    • Colleen Fitzgerald - Clinical Research Manager