• Sadarangani, Manish

    Titles

    Investigator, BC Children's Hospital
    Assistant Professor, Department of Pediatrics, University of British Columbia
    Sauder Family Chair in Pediatric Infectious Diseases, University of British Columbia
    Director, Vaccine Evaluation Center, BC Children's Hospital

    Degrees / Designations

    BM, BCh, MRCPCH, DPhil

    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Phone
    604-875-2470
    Fax
    Lab Phone
    Assistant
    Cecilia Jankowski
    Assistant Phone
    604-875-2422
    Mailing Address

    BC Children's Hospital Research Institute
    Room A5-174 
    950 West 28th Avenue
    Vancouver, BC V5Z 4H4

    Affiliate Websites
    Research Areas
    • Vaccines and immunization including vaccine development, clinical trials and epidemiology of vaccine-preventable diseases
    • Meningococcal disease
    • Meningitis
    • Encephalitis
    • The influence of the human microbiota on infection and immunity
    Summary

    The aim of our research at the Vaccine Evaluation Center (VEC) is to lower the burden of childhood infectious disease through vaccination by building an evidence base for local, national and international vaccine policy. My research program includes laboratory studies to develop new and better vaccines, clinical trials to identify how best to utilize new and approved vaccines, and population-based investigations to identify targets for new vaccines and demonstrate vaccine impact.

    Current Projects

    Haemophilus influenzae type a (Hia) causes meningitis and septicemia, with particularly high rates in indigenous populations. In this collaboration with the Northern Ontario School of Medicine, we will be assessing specific risk factors for Hia disease, the burden of invasive disease, mucosal disease (such as otitis media and pneumonia) and asymptomatic carriage of Hia. We will also be carrying out seroeipdemiology studies to assess anti-Hia antibodies in salvia and serum as an indication of exposure. These data will provide the information needed for the implementation of a new immunization policy for a Hia vaccine which is currently in development. Determination of immunological correlates of protection against invasive Hia disease and identification of the target populations groups for immunization will be of particular importance to design future clinical trials of these vaccines.

    Selected Publications
    For the latest publications, please visit Dr. Sadarangani's ORCID profile.

    1. Martin NG, Iro M, Sadarangani M, Goldacre R, Pollard AJ, Goldacre MJ. Hospital admissions for viral meningitis in children in England over five decades: a population based observational study. The Lancet Infectious Diseases 2016; in press

    2. Voysey M, Sadarangani M, Clutterbuck E, Bolgiano B, Pollard AJ. The impact of administration of conjugate vaccines containing cross reacting material on Haemophilus influenzae type b antibody responses in infants: A systematic review and meta-analysis of randomised controlled trials. Vaccine 2016; 34: 3986-3992 PMID: 27349840

    3. Arrieta MC*, Sadarangani M*, Brown EM, Russell SL, Nimmo M, Dean J, Turvey SE, Chan ES, Finlay BB. A humanized microbiota mouse model of ovalbumin-induced lung inflammation. Gut Microbes 2016; doi: 10.1080/19490976.2016.1182293 PMID: 27115049

    4. Jones C*, Sadarangani M*, Lewis S, Payne I, Saleem M, Derrick JP, Pollard AJ. Characterisation of the immunomodulatory effects of meningococcal Opa proteins on human peripheral blood mononuclear cells and CD4+ T cells. PLoS One 2016; 11: e0154153 PMID: 27111850

    5. Sadarangani M, Tam H, McDonald S, Fidler S, Foster C. Response to Hepatitis B virus vaccine in young adults with perinatally acquired HIV infection. Journal of Infection 2015; 71: 495-497 PMID: 26072139

    6. Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Bettinger JA; for the investigators of the Canadian Immunization Monitoring Program, ACTive (IMPACT). Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study. Clinical Infectious Diseases 2015; 60: e27-35 PMID: 25605282

    7. Sadarangani M, Willis L, Kadambari S, Gormley S, Young Z, Beckley R, Gantlett K, Orf K, Blakey S, Martin NG, Kelly DF, Heath PT, Nadel S, Pollard AJ. Childhood meningitis in the conjugate vaccine era: a prospective cohort study. Archives of Disease in Childhood 2015; 100: 292-294 PMID: 25256088

    8. Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Bettinger JA; for the investigators of the Canadian Immunization Monitoring Program, ACTive (IMPACT). The impact of the meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012. Clin Inf Dis 2014; 59: 1208-1215 PMID: 25069868

    9. Martin N, Sadarangani M, Pollard AJ, Goldacre MJ. Hospital admission rates for meningitis and septicaemia caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in children in England over five decades: a population-based observational study. Lancet Infectious Diseases 2014; 14: 397-405 PMID: 24631222

    10. Norheim G, Sadarangani M, Omar O, Yu L, Mølbak K, Howitz M, Olcén P, Haglund M, van der Ende A, Pollard AJ. Association between population prevalence of smoking and incidence of meningococcal disease in Norway, Sweden, Denmark and the Netherlands between 1975 and 2009: a population-based time series analysis. British Medical Journal Open 2014; 4: e003312 PMID: 24513866

    Grants

    2016 European Society for Paediatric Infectious Diseases. The effect of latent cytomegalovirus infection on response to conjugate vaccines in children. €5999,18

    2015-2017 Meningitis Research Foundation. Using high-throughput genomic sequencing to determine the aetiology of meningitis in UK children. £83,181

    2015-2017 Thrasher Research Fund Early Career Award Program Grant (Mentor). Investigating the effect of Intravenous immunoglobulin treatment on the immunological and inflammatory response in childhood encephalitis. US$26,750

    2014-2019 National Institute for Health Research Efficacy and Mechanism Evaluation Programme. Intravenous immunoglobulin in the management of encephalitis in children. £2,062,568

    2014-2016 Academy of Medical Sciences Starter Grant for Clinical Lecturers (Principal Applicant). Using gene expression analysis to rationally design future vaccines, by investigation of the immune response to the novel meningococcal vaccine MenPF in a phase I trial. £30,000

    2014-2015 The Jenner Institute Transcriptomics Core Facility, University of Oxford (Principal Applicant). Gene expression analysis to investigate the immune response to the novel meningococcal vaccine MenPF in a phase I trial. £8,636

    2014-2015 University of Oxford Medical Research Fund (Principal Applicant). Evaluation of rotavirus vaccine administration in premature babies in the neonatal unit. £10,000

    2012-2015 Pfizer Investigator-Initiated Research. Defining meningitis in UK children in the conjugate vaccine era. £69,294

    2012-2015 Meningitis Research Foundation. Defining meningitis in UK children in the conjugate vaccine era. £324,168


     

    Honours & Awards
    Research Group Members