• Datta, Anita

    Titles
    Clinical Assistant Professor, Neurology, University of Saskatchewan 
    Pediatric Neurologist and Epileptologist, Pediatric Neurology Program Director, Epilepsy Fellowship
    Degrees / Designations
    MD, College of Medicine, University of Saskatchewan  

    Undergraduate studies, University of Saskatchewan

    Primary Area of Research
    Brain, Behaviour & Development
    Secondary Area(s) of Research
    Phone
    604-875-2345 ext. 3534
    Fax
    Lab Phone
    Mailing Address
    Room K3- 145 
    4480 Oak Street
    Vancouver, BC V6H 3V4
    Affiliate Websites
    Research Areas

    Pediatric Neurology, Epilepsy

    Summary

    Research is primarily focused on epilepsy in the pediatric population.

    Current Projects
    A three-arm, randomized, double-blind, placebo-controlled study of the efficacy and safety of two trough-ranges of everolimus as adjunctive therapy in patients with tuberous sclerosis complex (TSC) who have refractory partial-onset seizures:

    The main purpose of this study is to find out if the drug everolimus (Afinitor®) is safe and has helpful effects in patients with tuberous sclerosis complex (TSC) who have refractory partial-onset seizures.  These are seizures that involve some type of body movement and are not adequately responding to ongoing treatment with epilepsy drugs.  Many patients with TSC develop seizures.  We are not sure if the seizures are caused by growth of certain cells in the brain or by changes in the way cells in the brain work together.  Studies in animals that have changes in their brain similar to those seen with TSC, have demonstrated that seizures can be reduced by use of the everolimus.

    Impact of Pediatric Epilepsy Surgery on Health-Related Quality Of Life:  

    The objective of this study is to evaluate the effectiveness of two treatments, epilepsy surgery relative to medical therapy, on improving health related quality of life (HRQL) longitudinally. The surgical group will be compared to a medical treatment group which has undergone work-up for surgery but deemed unsuitable for surgery. These two groups have been shown to have similar baseline characteristics. Outcome will be addressed using a novel comprehensive model that acknowledges a number of variables such as clinical status (seizure control), patient factors (mood and self-concept) and family factors (caregivers’ mood, family adaptation, resources and demands) can affect changes in HRQL. 

    Clinical Experience with Perampanel in the Pediatric Population in two Canadian Centers:  

    The purpose of this study is to describe the efficacy, tolerability and side effects of Perampanel in pediatric patients with refractory epilepsy. To do so, a retrospective detailed chart review of eligible patients at BCCH will be completed. 

    Selected Publications

    Datta A, Wong P, The Epilepsy Program at BC Children’s Hospital, Braindchild (the Official Journal of the Hong Kong Society of Child Neurology and Developmental Paediatrics), [Accepted for Publication]

    Datta AN, Snyder TJ, Wheatley MB, Jurasek L, Ahmed SN, Gross DW, Sinclair DB, Intelligence Quotient is not Affected by Epilepsy Surgery in Childhood, Pediatric Neurology, 2011 Feb;44(2):117-21

    Datta A, Picker J, Rotenberg A, Trisomy 8 Mosaicism and Favorable Outcome after Treatment of Infantile Spasms: Case Report, Journal of Child Neurology, 2010 Oct; 25(10): 1275-7

    Datta A, Sinclair DB, Wheatley M, Jurasek L, Snyder T, Quigley D, Ahmed SN, Gross D, Selective Amygdalohippocampectomy: Surgical Outcome in Children versus Adults, Can J Neurol Sci. 2009 Mar; 36(2): 187-91

    Datta A, Hahn C, Sahin M, Clinical Presentation and Diagnosis of Tuberous Sclerosis Complex in Infancy, Journal of Child Neurology, 2008; 23: 268-273

    Dyment DA, Cader MZ, Datta A, Broxholme SJ, Cherny S, Willer CJ, Ramagopalan S, Herrera BM, Orton S, Chao M, Sadovnick AD, Hader M, Hader W, Ebers GC, A First Stage Genome-Wide Screen for Regions Shared Identical-by-Descent in Hutterite Families with Multiple Sclerosis, Am J Med Geet Part B, 2007

    Sinclair DB, Jurasek L, Wheatley M, Datta A, Gross D, Ahmed H, Quigley D, Snyder T, Aronyk K, McKean J, Discontinuation of Antiepileptic Drugs after Pediatric Epilepsy Surgery, Pediatric Neurology, Volume 37, Issue 3, September 2007, 200-202

    Datta A, Sinclair DB, Benign Epilepsy of Childhood with Rolandic Spikes: Typical and Atypical Varitants, Pediatric Neurology, 2007 March; Volume 36, Issue 3: 141-145

    Datta a, Wirell E, Prognosis of Seizures Occurring in the First Year of Life, Pediatric Neurology, 2000 May; 22(5): 386-91

    Grants
    Honours & Awards
    • TopScholar Epilepsy Fellow, Seattle, WA; supported by an educational grant from Ortho-McNeil Neurologics, Inc. (December 2008)
    • Annual Meeting Resident Scholarship, American Academy of Neurology (2006)
    • International Federation of Medical Students Association Student Exchange Award, Neurology & Pediatrics, Tampere, Finland (Summer 2001)
    • Chancellor’s Scholarship, University of Saskatchewan, Canada (1997 – 1999)
    • John and Jack Spencer Middleton Undergraduate Scholarship, University of Saskatchewan, Canada (1999-2000)
    • John Labatt’s Undergraduate Scholarship, University of Saskatchewan, Canada (1999-2000)
    • Dean’s Scholarship, University of Saskatchewan, Canada (1998-2000)
    • Golden Key Undergraduate Scholarship, University of Saskatchewan, Canada (1999)
    • University Entrance Scholarship, McGill University, Canada (1997)
    Research Group Members