• Senger, Christof

    Investigator, BC Children's Hospital

    Clinical Assistant Professor, Department of Pathology and Laboratory Medicine, University of British Columbia

    Degrees / Designations
    Primary Area of Research
    Healthy Starts
    Secondary Area(s) of Research
    Lab Phone
    Mailing Address

    Children's and Women's Health Centre of BC
    Room 2H54
    4480 Oak Street
    Vancouver, BC V6H 3V4

    Affiliate Websites
    Research Areas
    • Placental pathology
    • Pediatric renal neoplasms
    • Bone/soft tisue pathology

    I am interested in exploring whether certain functional placental structures and their location and timing of development are factors in normal pregnancy outcome. Conversely, I am also interested in identifying specific placental development factors that are associated with poor pregnancy outcomes or long term health problems. 

    Current Projects

    1) Ongoing collaborative work is aimed at defining objective tests or measurements to distinguish constitutionally small from growth restricted fetuses. This work is being done as part of a multidisciplinary and multi-institutional study including the maternal-fetal medicine and pathology divisions at BC Children's and Women's Hospital and The Ottawa Hospital. This study seeks to correlate results of rests that are done in pregnancy including ultrasounds and Doppler as well as novel testing for proteins in the maternal serum (angiogenic growth factors) with placental pathology.

    2) Ongoing collaborative work with colleagues at the University of Ottawa is aimed at developing standardized “synoptic” templates for placental pathology reporting.

    Selected Publications

    Jessica Tam, Wa Sham Cheung, Christof Senger, Mark Reichman, Karen M Campbell. Melanotic neuroectodermal tumour of infancy: a case report. J Can Dent Assoc 2015; 81:f7. PMID: 26030601

    Sharma AA, Jen R, Brant R, Ladd M, Huang Q, Skoll A, Senger C, Turvey SE, Marr N, Lavoie PM.  Hierarchical maturation of innate immune defences in very preterm neonates. Neonatology. 2014;106(1):1-9. doi: 10.1159/000358550. Epub 2014 Mar 6.
    PMID: 24603545

    Sharma AA, Jen R, Kan B, Sharma A, Marchant E, Tang A, Gadawski I, Senger C, Skoll A, Turvey SE, Sly LM, Côté HC, Lavoie PM. Impaired NLRP3 inflammasome activity during fetal development regulates IL-1β production in human monocytes.  Eur J Immunol. 2014 Oct 14.
    PMID: 25311115

    Lehman A, Stittrich AB, Glusman G, Zong Z, Li H, Eydoux P, Senger C, Lyons C, Roach JC, Patel M. Diffuse angiopathy in Adams-Oliver syndrome associated with truncating DOCK6 mutations. Am J Med Genet A. 2014 Aug 4. doi: 10.1002/ajmg.a.36685.
    PMID: 25091416

    Cohen ASA, Townsend KN, Xiang Q-S, Attariwala R, Borchers C, Senger C, Picker W, Levi J, Yewchuk L. Tan J, Eydoux P, Lum A, Yong S-L, McKinnon ML, Lear SA, Everett R, Jones SJM, Yip S, Gibson WT. Somatic mosaicism for the p.His1047Arg mutation in PIK3CA in a girl with mesenteric lipomatosis. Am J Med Genet Part A 9999:1-5. [E Pub 5 June 2014.]
    PMID: 24903541

    McKinnon ML, Rozmus J, Fung SY, Hirschfeld AF, Del Bel KL, Thomas L, Marr N, Martin SD, Marwaha AK, Priatel JJ, Tan R, Senger C, Tsang A, Prendiville J, Junker AK, Seear M, Schultz KR, Sly LM, Holt RA, Patel MS, Friedman JM, Turvey SE. Combined immunodeficiency associated with homozygous MALT1 mutations. J Allergy Clin Immunol. 2013 Dec 11. pii: S0091-6749(13)01706-5.
    PMID: 24332264

    Christof Senger. Abnormal pericyte recruitment in fetal placental vasculature: cause of IUGR and fetal thrombotic vasculopathy in Adams-Oliver syndrome? Placenta 09/2013; 34(9):A11.

    Tsang HH, Dolman PJ, Courtemanche DJ, Rassekh SR, Senger C, Lyons CJ. Prenatal Presentation of Fronto-orbital Congenital Infantile Fibrosarcoma: A Clinicopathologic Report. JAMA Ophthalmol. 2013 Apr 4:1‐3.
    PMID: 23559269

    Turvey SE, Leo SH, Boos A, Deans GD, Prendiville J, Crawford RI, Senger C, Conley ME, Tilley P, Junker A, Janz L, Azana R, Hoang L, Morton TL. Successful approach to treatment of Helicobacter bilis infection in X-linked agammaglobulinemia.J Clin Immunol. 2012 Dec;32(6):1404-8.
    PMID: 22843217

    Ragotte RJ, Dhanrajani A, Pleydell-Pearce J, Del Bel KL, Tarailo-Graovac M, van Karnebeek C, Terry J, Senger C, McKinnon ML, Seear M, Prendiville JS, Tucker LB, Houghton K, Cabral DA, Guzman J, Petty RE, Brown KL, Tekano J, Wu J, Morishita KA, Turvey SE. The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus. Clin Immunol. 2016 Dec 31 PMID: 28043923 
    Honours & Awards
    Research Group Members