• Metzger, Daniel L.

    Investigator, BC Children's Hospital

    Pediatric Endocrinologist, BC Children's Hospital 

    Clinical Professor, Division of Endocrinology, Department of Pediatrics, University of British Columbia

    Degrees / Designations
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Lab Phone
    Mailing Address
    BC Children's Hospital
    Endocrinology & Diabetes Unit
    Room K4-213
    4480 Oak Street
    Vancouver, BC V6H 3V4
    Affiliate Websites
    Research Areas
    Type 1 diabetes

    My research is primarily involved in the development, prevention and treatment of type 1 (insulin-dependent or juvenile-onset) diabetes.

    I am an investigator in several multicenter clinical trials involved in preventing type 1 diabetes. In addition, I collaborate with basic-science researchers from the BC Research Institute and from the The Centre of Human Islet Transplant and Beta Cell Regeneration at VGH, helping provide clinical material (most commonly, blood samples) for their research.

    I also maintain our Division's large website providing resources for families of children with diabetes and other endocrine disorders, and for the professionals caring for these patients.

    Most recently, working with local and provincial resources, I have helped initiate an endocrine treatment program for transgendered youth.

    Current Projects

    I am currently involved in two multicenter trials involved with either the prevention or the early treatment of type 1 diabetes: the Diabetes TrialNet and the TRIGR (Trial to Reduce IDDM in the Genetically at Risk).

    I also work closely with basic-science researchers at BCRI and at The Centre of Human Islet Transplant and Beta Cell Regeneration at VGH on an variety of studies related to the various immunological processes involved in the development of type 1 diabetes in humans.

    Finally, I am a co-investigator in research evaluating a comprehensive provincial health care model for children with diabetes using existing population databases.

    Selected Publications

    Lawrence SE, Cummings EA, Pacaud D, Lynk A, Metzger DL. Joint Position Statement from the Canadian Paediatric Society and the Canadian Pediatric Endocrine Group. Managing type 1 diabetes in school: recommendations for policy and practice. Paediatr Child Health 2015:20(1):35–39. PMID: 25722642.

    Cheung SSC, Ou D, Metzger DL, Meloche M, Ao Z, Ng SSW, Owen D, Warnock GL. B7-H4 expression in normal and diseased human islet β cells. Pancreas 2014;43(1):128–134. PMID: 24326367.

    Rodd C, Metzger DL, Sharma A, for the Canadian Pediatric Endocrine Group Working Committee for National Growth Charts. Extending WHO weight-for-age reference curves to older children. BMC Pediatr 2014;14:32. PMID: 24490896.

    Khatchadourian K, Amed S, Metzger DL. Clinical management of youth with gender dysphoria in Vancouver. J Pediatr 2014;164(4):906–911. PMID: 24315505.

    Hasan H, Howard F, Morgan SG, Metzger DL, Lo AC, Goddard K. Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada. Healthcare Policy 2014;9(3):80–96. PMID: 24726076.

    Hasan H, Howard AF, Metzger DL, Gill S, Johnson M, Lo AC, Goddard K. Canadian endocrinologists’ views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height. BC Med J 2014;56(5):230–235.

    Knip M, Åkerblom HK, Becker D, Dosch HM, Dupre J, Fraser W, Howard N, Ilonen J, Krischer JP, Kordonouri O, Lawson ML, Palmer JP, Savilahti E, Vaarala O, Virtanen SM; TRIGR Study Group. Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial. JAMA 2014;311(22):2279–2287. PMID: 24915259.

    Li D, Opas EE, Tuluc F, Metzger DL, Hou C, Hakonarson H, Levine MA. Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: phenotypic and molecular characterization. J Clin Endocrinol Metab 2014;99(9):E1774–1783. PMID: 24823460.

    Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg J-H, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger DL, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, Bertollo de Alexandre R, Manning AD, Levy I, Keil MF, de la Luz Sierra M, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. N Engl J Med 2014;371(25):2363–2374. PMID: 25470569.

    Inman M, Hursh BE, Mokashi A, Pinto T, Metzger DL, Cummings EA. Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty. Horm Res Paediatr 2013;80(1):64–68. PMID: 23859950.

    Honours & Awards

    The Noni MacDonald Award, Canadian Pediatric Society — 2014

    Family-Centred Care Award of Distinction, BCCH Partners in Care — 2003

    Outstanding Achievement Award, Canadian Diabetes Association — 2003

    Dr. John Hunt Camping Spirit Award, Canadian Diabetes Association — 2004

    Education Award of Excellence with Distinction, C&W — 2006

    Charles H. Best Award, Canadian Diabetes Association — 2006

    Dr. Parminder Singh Award, British Columbia Pediatric Society — 2006

    Family-Centred Care Award, BCCH Partners in Care — 2007

    PHSA Patient & Family Centred Care Award — 2013

    Research Group Members