• Chan, Edmond S.

    Titles

    Investigator, BC Children's Hospital
    Head, Allergy and Immunology, BC Children’s Hospital
    Head, Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia
    Clinical Associate Professor, Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia

    Degrees / Designations
    MD, FRCPC
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2118
    Fax
    604-875-3653
    Lab Phone
    Mailing Address

    BC Children's Hospital
    Room 1C31B
    4480 Oak Street
    Vancouver, BC  V6H 3V4

    Affiliate Websites
    Research Areas
    • Food Allergy
    • Eosinophilic Esophagitis
    Summary

    1. Food allergy
    My research encompasses all clinical aspects of food allergy, including prevention, diagnosis, and management.

    Selected projects include:

    • Characterizing current practices among pediatricians, dietitians, family physicians, and parents on dietary exposures and allergy prevention
    • Bridging the gap between research findings and translation into clinical care. I have taken an active role nationally in health advocacy as lead author of the first Canadian position statement on allergy prevention and dietary exposure in high-risk infants, representing both the Canadian Paediatric Society and the Canadian Society of Allergy & Clinical Immunology (CSACI). My roles with the CSACI as past Pediatric section head and current Board of director have facilitated this work, which has now expanded to unified efforts with U.S. and international colleagues. We continue to work on initiatives locally in BC as well.
    • Utility of Ara h 2 component testing for peanut allergy diagnosis in Canadian children
    • Creation and investigation of an e-Health tool, for education of the general public on proper food allergy diagnosis
    • Confidence, knowledge, and skill with use of epinephrine auto-injectors for management of food allergy
    • The impact of pediatric allergist care on the quality of life of children with food allergy
    • Collaborator on CIHR / AllerGen sponsored food allergy registry studies (peanut, seafood), with colleagues at the University of Calgary and McGill
    • Collaborator on CIHR / AllerGen sponsored food immunotherapy studies (cow’s milk desensitization), with colleagues at McGill and other sites

    2. Eosinophilic Esophagitis (EoE)
    In 2012, I helped to create the multi-disciplinary EoE Clinic at BC Children’s Hospital, one of the only clinics dedicated to EoE in Canada. Dr. Vishal Avinashi (Gastroenterology) and I are both co-directors of the clinic.

    The clinic has had several research pursuits, including the following projects:

    • EoE Registry – a prospectively collected registry with clinical data, including allergy, gastrointestinal, and nutritional parameters
    • Characterization of ethnicity for childhood EoE in BC
    • Cow’s milk elimination for management of EoE
    • Adrenal suppression among children being treated for EoE
    Current Projects
    Selected Publications

    Cherkaoui S, Ben-Shoshan M, Alizadehfar R, Asai Y, Chan E, Cheuk S, Shand G, St-Pierre Y, Harada L, Allen M, Clarke A. Accidental exposures to peanut in a large cohort of Canadian children with peanut allergy. Clin Transl Allergy. 2015 Apr 2;5:16. doi: 10.1186/s13601-015-0055-x. eCollection 2015. PubMed PMID: 25861446; PubMed Central PMCID: PMC4389801.

    Issa-El-Khoury K, Kim H, Chan ES, Vander Leek T, Noya F. CSACI position statement: systemic effect of inhaled corticosteroids on adrenal suppression in the management of pediatric asthma. Allergy Asthma Clin Immunol. 2015 Mar 14;11(1):9. doi: 10.1186/s13223-015-0075-z. eCollection 2015. PubMed PMID: 25802532; PubMed Central PMCID: PMC4369840.

    Lavine E, Clarke A, Joseph L, Shand G, Alizadehfar R, Asai Y, Chan ES, Harada L, Allen M, Ben-Shoshan M. Peanut avoidance and peanut allergy diagnosis in siblings of peanut allergic children. Clin Exp Allergy. 2015 Jan;45(1):249-54. doi: 10.1111/cea.12403. PubMed PMID: 25207855.

    Wong T, Ko HH, Chan ES. IgE-Mediated allergy to wheat in a child with celiac disease - a case report. Allergy Asthma Clin Immunol. 2014 Nov 10;10(1):56. doi: 10.1186/1710-1492-10-56. eCollection 2014. PubMed PMID: 25788950; PubMed Central PMCID: PMC4363205.

    Chan ES, Cummings C et al.: Dietary exposures and allergy prevention in high-risk infants: a joint position statement of the Canadian Society of Allergy and Clinical Immunology and the Canadian Paediatric Society. Allergy, Asthma & Clinical Immunology 2014 10:45. doi:10.1186/1710-1492-10-45. PMID: 25908933.

    Chin B, Chan ES, Goldman RD. Early exposure to food and food allergy in children. Can Fam Physician. 2014 Apr;60(4):338-9. PubMed PMID: 24733323; PubMed Central PMCID: PMC4046529.

    Cook VE, Chan ES. Anaphylaxis in the acute care setting. CMAJ. 2014 Jun 10;186(9):694. doi: 10.1503/cmaj.131130. Epub 2014 Mar 3. Review. PubMed PMID: 24591280; PubMed Central PMCID: PMC4049994.

    Chan ES, Cummings C; Canadian Paediatric Society, Community Paediatrics Committee and Allergy Section. Dietary exposures and allergy prevention in high-risk infants: A joint statement with the Canadian Society of Allergy and Clinical Immunology. Paediatr Child Health. 2013 Dec;18(10):545-54. English, French. PubMed PMID: 24497783; PubMed Central PMCID: PMC3907352.

    A Haynes, S Leo, ES Chan, R Chafe, LA Newhook. Early nutrition in the prevention of allergic disease: A survey of general paediatricians and dietitians in Atlantic Canada. Paediatr Child Health 2013;18(5):e20-e25.

    Rouleau I, De Serres G, Drolet JP, Banerjee D, Lemire C, Moore A, Paradis L, Alizadhefar R, Des Roches A, Chan ES, Stark D, Benoit M, Skowronski DM; PCIRN (Public Health Agency of Canada–Canadian Institutes for Health Research Influenza Research Network). Allergic symptoms after pandemic influenza vaccination rarely mediated by vaccine-specific IgE. J Allergy Clin Immunol. 2012;130(6):1423-6. PMID: 22958947.

    Des Roches A, Paradis L, Gagnon R, Lemire C, Bégin P, Carr S, Chan ES, Paradis J, Frenette L, Ouakki M, Benoît M, De Serres G; PCIRN (Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network). Egg-allergic patients can be safely vaccinated against influenza. J Allergy Clin Immunol. 2012;130(5):1213-1216. PMID: 23021881.

    Carr S, Chan E, Lavine E, Moote W. CSACI Position statement on the testing of food-specific IgG. Allergy Asthma Clin Immunol. 2012;8(1):12. PMID: 22835332.

    Leo S, Dean J, Chan ES. What are the beliefs of pediatricians and dietitians regarding complementary food introduction to prevent allergy? Allergy Asthma Clin Immunol. 2012;8:3. PMID: 22436326

    Kumar R, Chan ES, Warrington R. Idiopathic Angioedema: Is it a Distinct Clinical Syndrome? Can J Allergy Clin Immunol 2002; 7 (5/6): 79-82.

    Simons FER, Chan ES, Gu X, Simons KJ. Epinephrine for the out-of-hospital (first-aid) treatment of anaphylaxis in infants: Is the ampule/syringe/needle method practical? J Allergy Clin Immunol 2001; 108: 1040-4. PMID: 11742286.

    Grants
    Honours & Awards

    UBC Department of Pediatrics, Ivory Tower Award, in recognition of contributions to promoting resident research and academic medicine - 2014

    Clinical Faculty Award for Excellence in Clinical Teaching, UBC Faculty of Medicine - 2012

    Family Centered Care Award, Partners in Care, BC Children's Hospital and BC Children's Hospital Foundation - 2012

    Award of Distinction, Partners in Care, BC Children's Hospital and BC Children's Hospital Foundation - 2011

    Family Centered Care Award, Partners in Care, BC Children's Hospital and BC Children's Hospital Foundation - 2011 

    Fellow of the American Academy of Allergy, Asthma and Immunology- 2008

    Research Group Members
    • Dr. E. Portales-Casamar – Clinical Assistant Professor, Division of Allergy & Immunology
    • I. Baerg – Research nurse
    • Dr. A. Lyttle – Pediatric allergy/immunology fellow
    • Dr. V. Cook – Pediatric resident
    • Dr. B. Chin – Pediatric resident
    • C. Koo – Medical student
    • T. Teoh – Medical student